An agitator for a heparin sodium purification process

Abstract

The present application relates to the field of stirring mixing, in particular to a stirring device for heparin sodium purification process, comprising a stirring cylinder, a driving mechanism connected to the stirring cylinder, a shaft pipe connected to the driving mechanism, and two stirring parts fixedly connected to the shaft pipe, the two stirring parts are symmetrically arranged, the stirring part is of hollow structure, an opening is formed at one end of the stirring part, a cover plate is rotatably connected to the upper end of the stirring part, a torsional spring is installed at the rotating connection between the cover plate and the stirring part, a conversion plate is fixedly connected to the upper end of the cover plate, the conversion plate is arc-shaped, a plurality of through grooves are formed in the cover plate, and a hook is fixedly connected near each through groove, the device can use the stirring structure to extract the oil and impurities floating on the liquid surface, and further improve the heparin sodium purification efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of stirring mixing, in particular to a stirring device for heparin sodium purification process. BACKGROUND

[0002] Heparin sodium is an anticoagulant, and the main raw material for processing heparin sodium is pig small intestine mucosa. When heparin sodium is purified, fresh pig small intestine is taken, the mucosa of the pig small intestine is scraped off, and sodium hydroxide solution is added to the twisted pig small intestine mucosa to remove grease and impurities. After filtration and centrifugation, the precipitate is taken to complete the crude purification of heparin sodium. In this process, the small intestine mucosa stirred with the addition of sodium hydroxide solution needs to be filtered and impurity-removed. Fat tissue and impurities float above the liquid surface, and the liquid needs to be transferred several times, increasing the difficulty of filtering and cleaning equipment. Therefore, the present application proposes a stirring device for heparin sodium purification process. SUMMARY

[0003] Therefore, the present application aims to solve the technical problem by providing a stirring device for heparin sodium purification process, which can use the stirring structure to extract the grease and impurities floating on the liquid surface, and further improve the purification efficiency of heparin sodium.

[0004] A stirring device for heparin sodium purification process, comprising a stirring cylinder, a driving mechanism connected to the stirring cylinder, a shaft pipe connected to the driving mechanism, and two stirring parts fixedly connected to the shaft pipe, wherein the two stirring parts are symmetrically arranged, the stirring part is an internal hollow structure, an opening is formed at one end of the stirring part, a cover plate is rotatably connected to the upper end of the stirring part, a torsional spring is installed at the rotating connection between the cover plate and the stirring part, a conversion plate is fixedly connected to the upper end of the cover plate, the conversion plate is arc-shaped, a plurality of through grooves are formed in the cover plate, and a hook is fixedly connected near each through groove.

[0005] A spiral blade is fixedly connected to each stirring part, and the connection between the spiral blade and the stirring part gradually thins towards the edge.

[0006] A suction pipe is fixedly connected to the upper end of the shaft pipe, and two hoses are fixedly connected to the lower end of the suction pipe and communicate with the interiors of the two stirring parts, respectively.

[0007] Two notches are formed in the shaft pipe, and a rotating rod is rotatably connected in the middle of each notch. A material shifting plate is fixedly connected to the lower end of each rotating rod. The lower part of each material shifting plate is in a vertical state, and the upper part is arc-shaped.

[0008] A plurality of flow guide strips are fixedly connected to the inner surfaces of the two material shifting plates.

[0009] Two limit grooves are formed on the two rotating rods, a sliding rod is slidably connected in the shaft tube, two round rods are fixedly connected to the upper end of the sliding rod, the two round rods are slidably connected in the two limit grooves respectively, a plug is fixedly connected to the lower end of the sliding rod, a spring is sleeved on the sliding rod, and the spring is located between the lower end of the shaft tube and the plug.

[0010] The driving mechanism comprises a lifting plate, a driving motor is fixedly connected to the lifting plate, a gear is fixedly connected to the output shaft of the driving motor and the shaft tube, and the two gears are in meshing transmission.

[0011] The application has the beneficial effects that the stirring structure is used to realize the degreasing and impurity removal of small intestine mucosa, the crude purification function of heparin sodium is further improved, compared with the method of stirring and then filtering and removing impurities, part of processes and special equipment are saved, and the purification efficiency of heparin sodium is further improved. BRIEF DESCRIPTION OF DRAWINGS

[0012] The application will be further described in detail in combination with the drawings and specific implementation methods.

[0013] Figure 1 It is a whole structure schematic view of the stirring device for the heparin sodium purification process;

[0014] Figure 2 It is a structure schematic view of the stirring part;

[0015] Figure 3 It is a structure schematic view of the matching sleeve;

[0016] Figure 4 It is a structure schematic view of the plug;

[0017] Figure 5 It is a structure schematic view of the spiral blade;

[0018] Figure 6 It is a structure schematic view of the cover plate;

[0019] Figure 7 It is a structure schematic view of the conversion plate;

[0020] Figure 8 It is a structure schematic view of the material pushing plate;

[0021] Figure 9 It is a structure schematic view of the shaft tube. DETAILED DESCRIPTION

[0022] The application will be described in detail in combination with the drawings in the embodiments of the application.

[0023] A kind of stirring device for heparin sodium purification process, including stirring cylinder 101, driving mechanism is connected on stirring cylinder 101, shaft tube 201 is connected on driving mechanism, two stirring parts 401 are fixedly connected on shaft tube 201, two stirring parts 401 are symmetrically arranged, stirring part 401 is hollow structure, opening 403 is formed in one end of stirring part 401, cover plate 404 is rotatably connected on the upper end of stirring part 401, torsional spring 408 is installed at the rotatable connection of cover plate 404 and stirring part 401, conversion plate 406 is fixedly connected on the upper end of cover plate 404, conversion plate 406 is arc-shaped, a plurality of through slots 405 are formed in cover plate 404, hook 407 is fixedly connected near each through slot 405.

[0024] Spiral blade 402 is fixedly connected on each stirring part 401, the connection of spiral blade 402 and stirring part 401 gradually thins towards edge.

[0025] Suction pipe 106 is fixedly connected on the upper end of shaft tube 201, two hoses 107 are fixedly connected on the lower end of suction pipe 106, two hoses 107 are communicated with the inside of two stirring parts 401 respectively.

[0026] Two notches 202 are formed in shaft tube 201, rotary bar 203 is rotatably connected in the middle of two notches 202, material shifting plate 205 is fixedly connected on the lower end of two rotary bars 203, the lower part of two material shifting plates 205 is vertical state, and the upper part is arc-shaped.

[0027] A plurality of flow guide strips 206 are fixedly connected on the inner surface of two material shifting plates 205.

[0028] Limit slot 204 is formed in the upper end of two rotary bars 203, sliding rod 301 is slidably connected in shaft tube 201, two round rods are fixedly connected on the upper end of sliding rod 301, two round rods are slidably connected in two limit slots 204 respectively, plug 303 is fixedly connected on the lower end of sliding rod 301, spring 302 is sleeved on sliding rod 301, spring 302 is located between the lower end of shaft tube 201 and plug 303, matching sleeve 304 is rotatably connected in stirring cylinder 101, plug slot is formed in matching sleeve 304.

[0029] Driving mechanism includes lifting plate 103, driving motor 105 is fixedly connected on lifting plate 103, gear 104 is fixedly connected on the output shaft of driving motor 105 and shaft tube 201, two gears 104 are engaged transmission, and shaft tube 201 is rotatably connected between lifting plate 103.

[0030] Two electric push rods 102 are fixedly connected on stirring cylinder 101, and lifting plate 103 is fixedly connected on the moving end of two electric push rods 102.

[0031] The shape of two stirring parts 401 is spiral, and arc chamfer is arranged at one end of two stirring parts 401.

[0032] The plurality of hooks 407 are V-shaped.

[0033] Referring to Figures 5-8 ,

[0034] When using the stirring device, first, the worker adds the scraped small intestinal mucosa into the stirring cylinder 101. Then, the worker adds dilute sodium hydroxide solution into the stirring cylinder 101, adjusts the PH value in the stirring cylinder 101 to 9-9.5, so that the oil and impurities in the small intestinal mucosa are separated, the sodium hydroxide can effectively denature the protein and avoid the degradation of heparin, the stirring cylinder 101 is connected with a heating device to control the internal temperature below 40℃, and the reaction is accelerated.

[0035] After adding the dilute sodium hydroxide solution, the worker controls the contraction of the moving end of the two electric push rods 102, drives the lifting plate 103 to move downward, drives the shaft tube 201 to move downward, and drives the two stirring parts 401 to be inserted into the stirring cylinder 101, so that the two stirring parts 401 are located below the liquid level.

[0036] By controlling the two gears 104 to mesh and drive, the shaft tube 201 is driven to rotate counterclockwise, the two stirring parts 401 are driven to rotate counterclockwise, and the two stirring parts 401 are spiral-shaped, so as to play a role in stirring the sodium hydroxide and the small intestinal mucosa. The spiral stirring part 401 generates shear force, thrust and circulation effect through rotation, can quickly break the stratification of the material, realizes the rapid separation of the oil, impurities and small intestinal mucosa, and compared with a high-shear stirrer, the shear force of the spiral blade on the material is more gentle, which is suitable for stirring and processing the small intestinal mucosa and avoids damaging the structure of the material.

[0037] The spiral blade 402 plays a role in assisting stirring, and further improves the spiral stirring effect of the stirring part 401. Since the connection part of the spiral blade 402 and the stirring part 401 gradually thins towards the edge, the contact area of the blade and the material is reduced, so as to further reduce the resistance generated between the blade and the liquid, and improve the stirring efficiency.

[0038] Since one end of the stirring part 401 is provided with an arc chamfer, and the stirring part 401 itself has a certain thickness, the arc chamfer plays a role in reducing the resistance of the stirring part 401, so that the spiral stirring effect is more obvious.

[0039] The arc chamfer replaces an acute angle or a right angle through a circular arc transition, so that the flow direction of the fluid changes more gently when passing through the edge, and avoids the generation of turbulent flow or vortex flow due to sudden turning.

[0040] Referring to Figures 1-4 and Figure 9 ,

[0041] When it is necessary to stir the small intestinal mucosa and the sodium hydroxide solution, the staff controls the shaft tube 201 to move downward into the stirring barrel 101, the shaft tube 201 drives the slide rod 301 inside to move downward, the slide rod 301 drives the plug 303 to insert into the matching sleeve 304, and the plug 303 can be gap-fitted with the matching sleeve 304.

[0042] After the plug 303 is in contact with the matching sleeve 304, the slide rod 301 slides upward due to the pressure, and the spring 302 is compressed under the force, and then the slide rod 301 can drive the two round rods at the upper end to slide in the two limiting grooves 204 respectively, so that the two rotating rods 203 are both rotated to the horizontal state, and the two stirring plates 205 are driven to the horizontal state after being opened, and the lower parts of the two stirring plates 205 are in contact with the liquid surface of the material.

[0043] During the counterclockwise rotation of the shaft tube 201, since the lower parts of the two stirring plates 205 are in the vertical state and the upper parts are in the arc shape, the two stirring plates 205 rotate counterclockwise to stir the small intestinal mucosa floating on the liquid surface, and the small intestinal mucosa is in contact with the inner arc surface of the stirring plate 205, so that the small intestinal mucosa flows downward, the vertical structure of the lower part of the stirring plate 205 forms stable support, and the arc-shaped gradual transition of the upper part can form a V-shaped flow guide channel. This structure can uniformly disperse the surface mucosa into the lower liquid flow, prevent local accumulation on the surface of the liquid, and make the small intestinal mucosa fully contact with the sodium hydroxide solution.

[0044] After the small intestinal mucosa and the sodium hydroxide solution are stirred, the moving ends of the two electric push rods 102 are controlled to extend, drive the shaft tube 201 to move upward, drive the slide rod 301 to move upward, and the plug 303 is separated from the matching sleeve 304. The slide rod 301 automatically slides downward and extends under the elastic action of the spring 302, while pulling the two rotating rods 203 to rotate upward and close, and the two rotating rods 203 drive the two stirring plates 205 to rotate to the vertical state respectively, realizing the function of automatically storing the two stirring plates 205. The above structure realizes the effect of automatically storing the two stirring plates 205, so as to reduce the occupied space and facilitate subsequent cleaning.

[0045] The plurality of flow guide strips 206 can further avoid the phenomenon that the liquid contacts the arc surface of the stirring plate 205 and surges upward, ensure that the small intestinal mucosa can flow downward, and the plurality of flow guide strips 206 on the stirring plate 205 play a role in guiding the liquid flow. When the two stirring plates 205 are rotated to the vertical state, the liquid adhered to the stirring plate 205 flows downward along the plurality of flow guide strips 206, so as to reduce the liquid adhered to the stirring plate 205, and further facilitate the subsequent cleaning.

[0046] Referring to Figures 5-9 ,

[0047] During the counterclockwise rotation of the stirring part 401, the cover plate 404 can be automatically buckled at the opening 403 of the stirring part 401 under the action of the torsion spring 408, and the opening 403 of the stirring part 401 can be shielded, so as to avoid the unchanged small intestinal mucosa from entering the stirring part 401.

[0048] Since the conversion plate 406 is arc-shaped, when the cover plate 404 is in the state of shielding the opening 403, the conversion plate 406 is in an inclined state, which can reduce the resistance of the stirring part 401 during the counterclockwise rotation and improve the spiral stirring effect.

[0049] Further, a plurality of through holes are arranged on the surface of the conversion plate 406, and the liquid can pass through the plurality of through holes, so as to further reduce the resistance generated by the conversion plate 406 during the rotation and stirring.

[0050] The inlet pipe and the suction pipe 106 of the liquid pump are rotatably connected, and then the two hoses 107 are respectively communicated with the two stirring parts 401. After the small intestinal mucosa and the sodium hydroxide solution are stirred, the moving end of the electric push rod 102 is controlled to extend to drive the shaft pipe 201 to move upward, the shaft pipe 201 drives the two stirring parts 401 to move upward, so that the two stirring parts 401 are located at the liquid surface. At this time, the driving motor 105 is used to drive the shaft pipe 201 to rotate clockwise, and the shaft pipe 201 drives the two stirring parts 401 to rotate clockwise.

[0051] The suction pipe 106 can not only suck liquid, but also can blow gas during the stirring process through the air pump to realize the bubble stirring effect and further promote the mixing of the small intestinal mucosa and the dilute sodium hydroxide solution.

[0052] Further, hot gas can also be blown by the air pump during the stirring process, so as to ensure the stirring effect and also maintain the uniform temperature of the liquid.

[0053] Since the conversion plate 406 is arc-shaped, the liquid impact force contacts the concave surface of the conversion plate 406, and the conversion plate 406 rotates under the pushing of the liquid. Since the conversion plate 406 is integrally formed with the cover plate 404, the conversion plate 406 rotates and is attached to the surface of the stirring part 401, and simultaneously drives the cover plate 404 to rotate and open, and the torsion spring 408 is in a stressed state. At this time, the oil floating on the liquid surface can enter the inside of the stirring part 401 through the opening 403, and then the oil is sucked out by the suction force generated by the liquid pump.

[0054] When the cover plate 404 is turned open, the plurality of hooks 407 are upward, and when the stirring part 401 rotates clockwise, impurities on the liquid surface, such as fat tissue and hair, impact on the cover plate 404, and the plurality of hooks 407 can hang the impurities, thereby achieving the function of collecting the impurities, and the liquid part can flow out through the plurality of through grooves 405 on the cover plate 404, further reducing the rotation resistance. Since the plurality of hooks 407 are V-shaped, the impurities can be hung at two angles, improving the collection effect of the impurities, and the V-shaped hooks 407 can avoid fat from blocking the plurality of through grooves 405, maintaining the smoothness of the plurality of through grooves 405.

[0055] Through the above structure, the stirring structure can realize the defatting and impurity removal of the small intestinal mucosa, further improve the crude purification function of heparin sodium, and compared with the method of stirring and then filtering and removing impurities, part of the process and special equipment are saved, and the purification efficiency of heparin sodium is further improved.

Claims

1. A stirring device for the purification process of heparin sodium, characterized in that: The system includes a mixing drum, a drive mechanism connected to the mixing drum, a shaft tube connected to the drive mechanism, and two symmetrically arranged mixing sections fixedly connected to the shaft tube. Each mixing section has a hollow internal structure and an opening at one end. A cover plate is rotatably connected to the upper end of each mixing section, and a torsion spring is installed at the rotatable connection between the cover plate and the mixing section. A conversion plate, which is arc-shaped, is fixedly connected to the upper end of the cover plate, and multiple through slots are formed on the cover plate. A hook is fixedly connected near each through slot. Each mixing section has a fixedly connected spiral blade, and the connection between the spiral blade and the mixing section gradually thins towards the edge. A suction pipe is fixedly connected to the upper end of the shaft tube, and two flexible hoses are fixedly connected to the lower end of the suction pipe, each hose communicating with the interior of one of the two mixing sections. Two... Two slots are connected to two rotating rods, each with a fixed material-pulling plate at its lower end. The lower part of the two material-pulling plates is vertical, while the upper part is arc-shaped. Multiple guide strips are fixedly connected to the inner surface of each material-pulling plate. Limiting grooves are provided on each of the two rotating rods. A sliding rod is slidably connected inside the shaft tube. Two round rods are fixedly connected to the upper end of the sliding rod, and the two round rods are slidably connected to the two limiting grooves. A plug is fixedly connected to the lower end of the sliding rod. A spring is sleeved on the sliding rod, located between the lower end of the shaft tube and the plug. A mating sleeve is rotatably connected inside the mixing drum, and a slot is provided inside the mating sleeve. The driving mechanism includes a lifting plate, on which a drive motor is fixedly connected. Gears are fixedly connected to the output shaft and shaft tube of the drive motor, and the two gears mesh for transmission.

2. A stirring device for the purification process of heparin sodium according to claim 1, characterized in that: Two electric actuators are fixedly connected to the mixing drum, and a lifting plate is fixedly connected to the moving end of the two electric actuators.

3. A stirring device for the purification process of heparin sodium according to claim 1, characterized in that: Both stirring sections are spiral-shaped, and one end of each stirring section is provided with an arc-shaped chamfer.

4. A stirring device for the purification process of heparin sodium according to claim 1, characterized in that: All hooks are V-shaped.

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