A novel laboratory liquid chromatograph

Abstract

This invention provides a novel laboratory liquid chromatograph, belonging to the field of chromatography technology, aiming to solve the problems of cumbersome operation and unstable clamping force in existing liquid chromatographs, leading to insecure or damaged reagent bottles. The device includes a chromatograph body and a placement box mounted on its top, with a fixing mechanism inside the placement box. The fixing mechanism includes a fixing seat, symmetrically arranged clamping plates, a push plate connected by buffer springs, a connecting block, a slider, a drive assembly, a lifting assembly, a drive rod, a drive block, and a positioning assembly. The fixing seat has a cavity and a first through groove. The drive assembly drives a threaded rod via a knob, causing the slider to move relative to the clamping plates, clamping the reagent bottles. The lifting assembly and positioning assembly are linked by gears, L-shaped toothed plates, inverted T-shaped blocks, and a positioning rack to automatically adjust the clamping force to accommodate reagent bottles of different sizes.

Description

Technical Field

[0001] This invention relates to the field of chromatography technology, and in particular to a novel liquid chromatograph for laboratory use. Background Technology

[0002] Liquid chromatography (LC) is a widely used analytical instrument in laboratories, used to separate and detect components in a sample based on the differences in their partition coefficients between the stationary and mobile phases. Its working principle involves a high-pressure pump injecting the mobile phase from the reservoir into the system. The sample solution enters the mobile phase via an injector and is loaded into the chromatographic column. Inside the column, the stationary phase adsorbs and desorbs the sample components, which then elute sequentially and are converted into electrical signals by a detector, resulting in a chromatogram. LC has important applications in chemistry, pharmaceuticals, and environmental monitoring, especially in high-throughput detection where the ease of operation and the stability of reagent bottle fixation are crucial.

[0003] In the prior art, for example, Chinese patent CN202510105530.0 discloses a high-performance liquid chromatograph, which uses a reagent bottle fixing component and a purification component to store and fix the reagent bottles. This design has a fixing component at the bottom of the reagent bottle storage box, including a base, a T-shaped slide, an annular skirt, an L-shaped support rod, and a bottom fixing unit, which, together with an upper clamping unit driven by an electric push rod, clamps and fixes the reagent bottles vertically. However, this technology has the following drawbacks:

[0004] 1. Operational complexity: The installation of reagent bottles requires the operator to manually press the reagent bottles into the arc-shaped flexible clamping block, and then fix them by driving the upper clamping unit through the electric push rod. The whole process involves multiple manual operations and electric control, which is cumbersome and inefficient. Especially in high-throughput detection scenarios, frequent manual adjustments increase the operation time and the possibility of human error.

[0005] 2. Insufficient clamping stability: The fixing component uses springs as the main source of clamping force. When the reagent bottle is small, the spring compression is small and the clamping force is insufficient, resulting in unstable clamping. The reagent bottle may move slightly during sampling, affecting the detection accuracy. When the reagent bottle is large, the spring compression is too large and the rebound force is too strong, which may damage the reagent bottle (especially glass), reducing the safety and reliability of the equipment. Summary of the Invention

[0006] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be construed as limiting the scope of the invention.

[0007] In view of the problems existing in the above and / or prior art, the present invention is proposed.

[0008] Therefore, the technical problem to be solved by the present invention is to overcome the shortcomings of existing liquid chromatographs, such as cumbersome operation, the need for multiple manual and electric operations, and the instability or damage to reagent bottles caused by the change of spring clamping force with the size of the reagent bottle.

[0009] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a novel laboratory liquid chromatograph, comprising a chromatograph body, a placement box installed on the top of the chromatograph body; and a fixing mechanism disposed inside the placement box, the fixing mechanism comprising a fixing seat fixedly installed on the bottom wall of the placement box, clamping plates symmetrically arranged on the left and right sides of the upper surface of the fixing seat, push plates fixedly connected to the opposite sides of the two clamping plates by buffer springs, sliders fixedly connected to the bottom ends of the two push plates by connecting blocks, and a driving component drivingly connected between the two sliders;

[0010] Each of the push plates, connecting blocks, and sliders on each side is equipped with a lifting component, and the opposite sides of the two clamping plates are fixedly equipped with a drive rod and a drive block that can drive the lifting component to operate. The bottom of the two sets of lifting components is equipped with a positioning component.

[0011] In a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, a reagent bottle is provided on the upper surface of the fixed base, and the reagent bottle is clamped between the two clamping plates.

[0012] As a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, a buffer pad is fixedly installed on the opposite surfaces of the two clamping plates, and the interior of the two buffer pads is filled with sponge.

[0013] As a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, the fixed base has symmetrical cavities on its left and right sides, and each of the two cavities has a first through groove at its top. The two push plates are slidably connected to the upper surface of the fixed base and are respectively located directly above the two first through grooves. The two connecting blocks are slidably connected in the two first through grooves, and the two sliders are slidably connected in the two cavities.

[0014] As a preferred embodiment of the novel laboratory liquid chromatograph of the present invention, the driving assembly includes a connecting shaft rotatably connected to the center of the fixed base, threaded rods are fixedly installed on both the left and right sides of the connecting shaft, and the two threaded rods are rotatably connected to the two cavities respectively. A rotating rod is fixedly connected to the left side of the left end of the threaded rod, and a knob is fixedly connected to the left end of the rotating rod through the inner wall of the fixed base and extending to its outside.

[0015] The outer surfaces of the two threaded rods are configured with opposite thread directions, and the two sliders are respectively slidably connected to the outer surfaces of the two threaded rods.

[0016] As a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, a rotating cavity is provided at the center of the push plate, and a second through groove is provided on the front side of the rotating cavity and between the push plate, the connecting block and the slider.

[0017] As a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, a partition is fixedly installed in the middle of the cavity, the slider is slidably connected above the partition, two sets of positioning racks are symmetrically installed on the front and rear sides of the bottom of the partition, and each set of positioning racks is composed of multiple triangular blocks, and a positioning groove is formed between every two triangular blocks, and a third through groove is opened in the middle of the partition.

[0018] In a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, the lifting assembly includes a gear rotatably connected within the rotating cavity, an L-shaped toothed plate meshing with the front side of the gear, an inverted T-shaped block fixedly connected to the bottom of the second through groove at the bottom end of the L-shaped toothed plate, the bottom end of the inverted T-shaped block penetrating the third through groove and extending below the partition, the vertical plate of the inverted T-shaped block slidably connected within the third through groove, and the horizontal plate positioned below the partition and in a parallel state.

[0019] A hollow rotating cylinder is fixedly connected to one end of the gear near the clamping plate. A spiral groove is provided on the inner wall of the hollow rotating cylinder. The drive rod is movably inserted into the inside of the hollow rotating cylinder, and the drive block is slidably connected in the spiral groove.

[0020] As a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, the positioning component includes fixing blocks fixedly installed at the front and rear ends of the horizontal plate of the inverted T-shaped block. The inner bottom walls of the two fixing blocks are fixedly connected with telescopic springs, and the top ends of the two telescopic springs are fixedly connected with limiting plates. The top ends of the limiting plates are fixedly connected with trapezoidal blocks, and the tips of the trapezoidal blocks penetrate the inner top wall of the fixing blocks and extend into the positioning grooves formed by each pair of triangular blocks above them.

[0021] In a preferred embodiment of the novel laboratory liquid chromatograph described in this invention, the plane of the trapezoidal block abuts against the plane of one of the triangular blocks, and the inclined surface of the other side of the trapezoidal block is parallel to the inclined surface of the other triangular block.

[0022] The beneficial effects of this invention are:

[0023] 1. This invention utilizes a purely mechanical structure driven by a single knob to achieve rapid clamping and loosening of reagent bottles, making operation simple and convenient. Compared to existing technologies that require multiple manual presses of the reagent bottle in conjunction with an electric push rod, this device uses a knob to drive a threaded rod, slider, and clamping plate, requiring only a single rotation to place and clamp the reagent bottle, significantly reducing operation steps and time. This single-step operation design is particularly suitable for high-throughput testing scenarios, effectively improving laboratory work efficiency and reducing operator workload.

[0024] 2. This invention solves the problem of unstable spring clamping force in existing technologies by using an adaptive clamping force adjustment mechanism. This mechanism, through the linkage of the lifting component, drive rod, drive block, and positioning component, in conjunction with a buffer spring and positioning rack, can automatically adjust the clamping force according to the size of the reagent bottle. For small-sized reagent bottles, the clamping force is moderate, ensuring stable clamping without loosening; for large-sized reagent bottles, the clamping force is controlled by a limiting mechanism to avoid overpressure damage to the reagent bottle, thus enhancing the versatility and safety of the equipment. Attached Figure Description

[0025] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0026] Figure 1 This is a perspective view of the overall structure of the present invention;

[0027] Figure 2 This is a perspective view of the reagent bottle being held by the fixing mechanism of the present invention;

[0028] Figure 3 This is a three-dimensional front sectional view of the fixing mechanism of the present invention;

[0029] Figure 4 This is a three-dimensional side sectional view of the fixing mechanism of the present invention;

[0030] Figure 5 For the present invention Figure 4 Enlarged structural diagram at point A;

[0031] Figure 6 This is a three-dimensional top sectional view of the connection between the push plate and the clamping plate of the present invention;

[0032] Figure 7 This is a three-dimensional enlarged view of the connection between the drive rod, drive block and hollow rotating cylinder of the present invention;

[0033] Figure 8 This is a three-dimensional enlarged cross-sectional view of the connection between the positioning component and the positioning rack of the present invention;

[0034] Figure 9 This is a perspective side sectional view of the connection between the push plate, connecting block, and slider of the present invention;

[0035] Figure 10 This is an enlarged perspective view of the lifting component and positioning component of the present invention.

[0036] In the picture:

[0037] 100. Chromatograph body; 101. Storage box; 102. Reagent bottle;

[0038] 200. Fixing mechanism; 201. Fixing seat; 201a. Cavity; 201b. First through slot; 202. Clamping plate; 203. Buffer spring; 204. Push plate; 204a. Rotating cavity; 204b. Second through slot; 205. Connecting block; 206. Slider; 207. Drive assembly; 207a. Connecting shaft; 207b. Threaded rod; 207c. Rotating rod; 207d. Knob; 208. Lifting assembly; 208 a. Gear; 208b. L-shaped toothed plate; 208c. Inverted T-shaped block; 208d. Hollow rotating cylinder; 208e. Spiral groove; 209. Drive rod; 210. Drive block; 211. Positioning assembly; 211a. Fixing block; 211b. Telescopic spring; 211c. Limiting plate; 211d. Trapezoidal block; 212. Buffer pad; 213. Partition plate; 213a. Third through groove; 214. Positioning rack; 214a. Triangular block. Detailed Implementation

[0039] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0040] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0041] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0042] Example

[0043] Figures 1-10This invention provides a novel laboratory liquid chromatograph with a scientifically designed and easy-to-operate structure. It effectively solves the problems of cumbersome operation and unsuitable clamping force in existing technologies, and is particularly suitable for stable clamping and rapid installation of reagent bottles of different sizes in high-performance liquid chromatography analysis. The structure and working principle of this invention are described in detail below with reference to specific embodiments and accompanying drawings.

[0044] This device includes a chromatograph body 100 and a placement box 101 mounted on top of the chromatograph body 100. The chromatograph body 100 is the main structure of the entire device, integrating core components such as a high-pressure pump, injector, and chromatographic column for sample separation and detection. The placement box 101 on top provides a sealed storage environment for reagent bottles 102, preventing external contamination and facilitating the fixing and sampling of reagent bottles. The placement box 101 contains a fixing mechanism 200 for securely holding the reagent bottles 102, ensuring their stability during the detection process. The fixing mechanism 200 includes a fixing seat 201 fixedly mounted on the bottom wall of the placement box 101. The fixing seat 201 serves as the supporting foundation for the entire fixing mechanism and is made of high-strength, corrosion-resistant materials to ensure long-term stability and reliability. The center of its upper surface is used to place the reagent bottle 102, and two clamping plates 202 are symmetrically arranged on the left and right sides. The clamping plate 202 is designed as a sturdy arc-shaped plate with a flat surface, which can clamp the reagent bottle 102 through relative movement. A buffer pad 212 is fixedly installed on its opposite side. The buffer pad 212 is filled with sponge, which has good flexibility and elasticity and can fit tightly against the outer wall of the reagent bottle 102. It can adapt to reagent bottles of different shapes and sizes (diameter range of 5-50mm) and at the same time buffer the clamping force to prevent the reagent bottle from being deformed or broken by pressure. It has a good protective effect, especially for glass reagent bottles.

[0045] A push plate 204 is fixedly connected to the opposite side of the clamping plate 202 via a buffer spring 203. The buffer spring 203 is made of high-elasticity steel and has a moderate elastic coefficient. Its main function is to provide clamping force and achieve adaptive adjustment. When the reagent bottle 102 is small, the compression of the buffer spring 203 is small, and the clamping force is moderate, ensuring stable clamping without loosening. When the reagent bottle 102 is large, the compression of the buffer spring 203 increases, and the clamping force is correspondingly enhanced. However, excessive compression is limited by the subsequent positioning component 211 to avoid damage to the reagent bottle. The push plate 204, as an intermediate component for transmitting clamping force, cooperates with the clamping plate 202. It absorbs the impact force during the clamping process through the elastic deformation of the buffer spring 203, protecting the reagent bottle 102. At the same time, a rotating cavity 204a is opened at the center of the push plate 204 to accommodate components such as the gear 208a of the lifting component 208, ensuring smooth mechanical linkage. The push plate 204, the connecting block 205 and the slider 206 are connected by a second through groove 204b. The second through groove 204b is a long strip groove structure that runs through the push plate 204, the connecting block 205 and the slider 206, providing sliding space for the L-shaped toothed plate 208b of the lifting component 208 and ensuring its stability in moving up and down.

[0046] The fixed base 201 has two symmetrical cavities 201a on its left and right sides. Each cavity 201a is rectangular, providing sliding and rotational space for the slider 206 and the threaded rod 207b. A first through slot 201b, a rectangular opening, is formed at the top of each cavity 201a, allowing the connecting block 205 to slide within it, ensuring precise and smooth horizontal movement of the push plate 204 and the clamping plate 202. Two push plates 204 are slidably connected to the upper surface of the fixed base 201, located directly above the two first through slots 201b. The push plates 204 move synchronously through a fixed connection at their bottom to the connecting blocks 205. The connecting block 205 is a robust rectangular block slidably connected within the first through slot 201b. Its function is to transmit the horizontal movement of the slider 206 to the push plates 204, ensuring stable movement of the clamping plate 202. Two sliders 206 are slidably connected in two cavities 201a respectively. The sliders 206 have a threaded hole structure and are threadedly connected to the threaded rod 207b. Horizontal movement is achieved by rotating the threaded rod 207b. Its bottom is in contact with the inner wall of the cavity 201a to reduce friction and improve motion accuracy.

[0047] The drive assembly 207 is the core mechanism for realizing the relative movement of the clamping plate 202. It includes a connecting shaft 207a rotatably connected to the center of the fixed base 201. The connecting shaft 207a is made of high-strength metal, passes through the center of the fixed base 201, and serves as a connection and transmission mechanism. Two threaded rods 207b are fixedly installed on its left and right sides. The threaded rods 207b are rotatably connected to the two cavities 201a respectively. A rotating rod 207c is fixedly connected to the left side of the left threaded rod 207b. The left end of the rotating rod 207c passes through the inner wall of the fixed base 201 and extends to the outside, where a knob 207d is fixedly connected. The knob 207d is a circular handle with a non-slip texture on the surface for easy rotation by the operator. It transmits rotational force to the connecting shaft 207a and the threaded rods 207b through the rotating rod 207c. The two threaded rods 207b have opposite thread directions on their outer surfaces: the left threaded rod 207b is right-handed, and the right threaded rod 207b is left-handed. This ensures that the two sliders 206 move relative to or away from each other when the threaded rods 207b rotate, thereby causing the clamping plate 202 to clamp or release the reagent bottle 102. The drive assembly 207 is operated by a single knob 207d, simplifying the clamping process and eliminating the cumbersome manual and electric operations required in the prior art.

[0048] The fixing mechanism 200 also includes a lifting assembly 208, a drive rod 209, a drive block 210, and a positioning assembly 211, which together constitute an adaptive clamping force adjustment mechanism to solve the problem of unstable spring clamping force in the prior art. The lifting assembly 208 is disposed inside the push plate 204, the connecting block 205, and the slider 206, and includes a gear 208a rotatably connected in the rotating cavity 204a. The gear 208a is a high-precision metal gear with high meshing accuracy and smooth rotation. An L-shaped toothed plate 208b is meshed on its front side. The L-shaped toothed plate 208b is an L-shaped metal plate with a rack structure on its vertical part, which meshes with the gear 208a. The horizontal part is fixedly connected to an inverted T-shaped block 208c through a second through slot 204b. The vertical plate of the inverted T-shaped block 208c is slidably connected within the third through slot 213a, while the horizontal plate is positioned below the partition 213 and fixedly connected to the positioning component 211. Its function is to convert the up-and-down movement of the L-shaped toothed plate 208b into the action of the positioning component 211, ensuring the accuracy of clamping force adjustment. A hollow rotating cylinder 208d is fixedly connected to one end of the gear 208a near the clamping plate 202. A spiral groove 208e is formed on the inner wall of the hollow rotating cylinder 208d, which is a continuous spiral track that guides the sliding of the drive block 210. The drive rod 209 is movably inserted into the hollow rotating cylinder 208d, and the drive block 210 is fixed to the outside of the drive rod 209 and slidably connected within the spiral groove 208e. The drive rod 209 and drive block 210 are driven by the clamping plate 202. When the clamping plate 202 is squeezed by the reagent bottle 102, the drive rod 209 moves into the hollow rotating cylinder 208d, and the drive block 210 slides along the spiral groove 208e, driving the hollow rotating cylinder 208d and the gear 208a to rotate, thereby driving the L-shaped toothed plate 208b and the inverted T-shaped block 208c to move up and down, realizing automatic adjustment of clamping force.

[0049] A partition 213, a sturdy metal plate, is fixedly installed in the center of the fixed base 201, dividing the cavity 201a into upper and lower parts. A slider 206 is slidably connected above the partition 213 to ensure stable movement. Two sets of positioning racks 214 are symmetrically installed on the front and rear sides of the bottom of the partition 213. Each set of positioning racks 214 consists of multiple triangular blocks 214a, forming a positioning groove between every two triangular blocks 214a. The positioning groove is trapezoidal in structure and is used to cooperate with the positioning component 211 to lock the clamping position. A third through groove 213a, a rectangular groove, is provided in the center of the partition 213. This groove allows the vertical plate of the inverted T-shaped block 208c to slide while limiting its lateral offset, ensuring precise vertical movement of the positioning component 211.

[0050] The positioning assembly 211 includes two fixing blocks 211a fixedly mounted at the front and rear ends of the upper surface of the inverted T-shaped block 208c. Each fixing block 211a has a hollow rectangular structure, with a telescopic spring 211b fixedly connected to its inner bottom wall. The telescopic spring 211b is made of a highly elastic material, providing stable rebound force. A limiting plate 211c, a flat metal plate, is fixedly connected to its top, supporting the trapezoidal block 211d. The trapezoidal block 211d is fixed to the top of the limiting plate 211c, with its tip penetrating the inner top wall of the fixing block 211a and extending into the positioning groove of the positioning rack 214. The plane of the trapezoidal block 211d abuts against the plane of one of the triangular blocks 214a, and the inclined surface on the other side is parallel to the inclined surface of the other triangular block 214a. This design ensures that when clamped, the trapezoidal block 211d engages in the positioning groove, locking the position of the clamping plate 202 and preventing further movement. Simultaneously, it allows the block to slide out through the inclined surface when released, ensuring smooth operation.

[0051] The overall working principle and effect of this device are as follows: First, when the operator rotates the knob 207d clockwise, the connecting shaft 207a and the two threaded rods 207b rotate in the same direction via the rotating rod 207c. Since the external threads of the two threaded rods 207b rotate in opposite directions, the two sliders 206 move horizontally relative to each other within the cavity 201a. Guided by the connecting block 205 and the first through groove 201b, the two push plates 204 move horizontally relative to each other. The push plates 204 push the two clamping plates 202 closer together, and the buffer pads 212 on the clamping plates 202 fit tightly against the outer wall of the reagent bottle 102, clamping the reagent bottle 102 placed at the center of the upper surface of the fixed seat 201. The flexibility of the buffer pads 212 and the internal sponge filling ensure a uniform distribution of clamping force, adapting to reagent bottles of different sizes and shapes, while protecting the reagent bottles from crush damage. When removing reagent bottle 102, the operator rotates knob 207d in the opposite direction, and threaded rod 207b drives slider 206 to move in opposite directions, so that clamping plate 202 moves away from reagent bottle 102. The operation is simple and convenient, and clamping or loosening can be completed with just one step of rotation, which is significantly better than the cumbersome process of multiple manual and electric operations in the prior art.

[0052] Secondly, this device solves the problem of unstable spring clamping force in existing technologies by setting an adaptive clamping force adjustment mechanism. This mechanism consists of components such as a lifting assembly 208, a drive rod 209, a drive block 210, a positioning assembly 211, and a positioning rack 214. Figures 1-10As shown, when the reagent bottle 102 is clamped and fixed, the buffer spring 203 on the back of the clamping plate 202 is in a compressed state, and the clamping force is provided by the buffer spring 203, which is adapted to the size of the reagent bottle 102. When the clamping plate 202 abuts against the reagent bottle 102, the operator continuously rotates the knob 207d, the push plate 204 squeezes the buffer spring 203, and the clamping plate 202 drives the drive rod 209 and the drive block 210 to extend into the hollow rotating cylinder 208d. The drive block 210 slides along the spiral groove 208e, driving the hollow rotating cylinder 208d and the gear 208a to rotate in the forward direction. The gear 208a drives the L-shaped toothed plate 208b to move upward, and the L-shaped toothed plate 208b drives the positioning component 211 upward through the inverted T-shaped block 208c. Under the push of the telescopic spring 211b, the trapezoidal block 211d in the positioning component 211 extends its tip into the positioning groove between the two triangular blocks 214a of the positioning rack 214. At this point, the plane of trapezoidal block 211d abuts against the plane of a triangular block 214a, and the inclined plane on the other side is parallel to the inclined plane of another triangular block 214a. Trapezoidal block 211d is stuck and cannot move further to one side, thus locking the movement of inverted T-shaped block 208c, L-shaped toothed plate 208b, slider 206, and push plate 204, preventing the clamping plate 202 from moving further relative to each other. At this time, the clamping force is provided by the compression force of the buffer spring 203. By reasonably designing the spring stiffness, the clamping force is ensured to be moderate, which can stably clamp small-sized reagent bottles while avoiding damage to large-sized reagent bottles due to excessive pressure, thus achieving adaptive clamping.

[0053] When it is necessary to release the clamping fixation of reagent bottle 102, the operator rotates knob 207d in the opposite direction, and threaded rod 207b drives slider 206 to move in the opposite direction. Since the inclined surface of trapezoidal block 211d is parallel to the inclined surface of triangular block 214a, under the guiding action of the inclined surface of triangular block 214a, trapezoidal block 211d is squeezed back into fixed block 211a, and telescopic spring 211b is compressed, allowing inverted T-shaped block 208c to move with slider 206. Slider 206 drives push plate 204 and clamping plate 202 away from reagent bottle 102 through connecting block 205, releasing the clamping fixation. At this time, reagent bottle 102 no longer presses clamping plate 202, and the rebound force of buffer spring 203 makes clamping plate 202 move away from push plate 204. Clamping plate 202 drives drive rod 209 and drive block 210 to move outward from inside hollow rotating cylinder 208d. The drive block 210 slides along the spiral groove 208e, generating a lateral force that drives the hollow drum 208d to rotate in the opposite direction. The hollow drum 208d drives the gear 208a to rotate in the opposite direction, and the gear 208a drives the L-shaped toothed plate 208b to move downward. The L-shaped toothed plate 208b drives the positioning assembly 211 downward through the inverted T-shaped block 208c, and the trapezoidal block 211d moves out of the positioning groove of the positioning rack 214. At this time, the moving resistance of the slider 206, push plate 204 and clamping plate 202 is reduced, and the operator can smoothly rotate the knob 207d to complete the release operation of the reagent bottle 102.

[0054] In summary, this device uses a single knob 207d to drive the threaded rod 207b and the slider 206, achieving relative movement of the clamping plate 202. Combined with the buffer pad 212 and the buffer spring 203, this ensures stable clamping of the reagent bottle 102. The adaptive clamping force adjustment mechanism automatically adjusts the clamping force through the linkage of the lifting assembly 208, the drive rod 209, the drive block 210, the positioning assembly 211, and the positioning rack 214. This adapts to reagent bottles of different sizes, preventing excessive or insufficient clamping force. Furthermore, the clamping operation is completed through a single-step rotation, significantly simplifying the operation process. This device has a compact structure, a purely mechanical design requiring no electric drive, high durability, and low maintenance costs. It is suitable for high-throughput detection scenarios in high-performance liquid chromatography (HPLC), effectively improving operational efficiency and the reliability of detection data.

[0055] It is important to note that the constructions and arrangements of this application shown in several different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, those who consult this disclosure will readily understand that many modifications are possible (e.g., changes in the size, dimensions, structure, shape, and proportions of various elements, as well as parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, orientation, etc.) without substantially departing from the novel teachings and advantages of the subject matter described in this application). For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of elements may be inverted or otherwise altered, and the nature or number or position of discrete elements may be changed or altered. Therefore, all such modifications are intended to be included within the scope of the invention. The order or sequence of any process or method steps may be changed or rearranged according to alternative embodiments. In the claims, any "device plus function" clause is intended to cover the structure described herein that performs the function, and not only structurally equivalent but also equivalent in structure. Other substitutions, modifications, alterations, and omissions may be made in the design, operation, and arrangement of the exemplary embodiments without departing from the scope of the invention. Therefore, the present invention is not limited to the specific embodiments, but extends to various modifications that still fall within the scope of the appended claims.

[0056] Furthermore, in order to provide a concise description of exemplary embodiments, not all features of actual embodiments (i.e., those features that are not relevant to the best mode of carrying out the invention as currently considered, or those features that are not relevant to implementing the invention) may be omitted.

[0057] It should be understood that numerous specific implementation decisions can be made during the development of any practical implementation, such as in any engineering or design project. Such development efforts may be complex and time-consuming, but for those skilled in the art who benefit from this disclosure, the development effort will be a routine work of design, manufacturing, and production without requiring much experimentation.

[0058] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A new type of liquid chromatograph for laboratory use, characterized by: include, The chromatograph body (100), and the mounting box (101) installed on the top of the chromatograph body (100); and, A fixing mechanism (200) is provided inside the placement box (101). The fixing mechanism (200) includes a fixing seat (201) fixedly installed on the bottom wall of the placement box (101). Clamping plates (202) are symmetrically arranged on the left and right sides of the upper surface of the fixing seat (201). Push plates (204) are fixedly connected to the opposite sides of the two clamping plates (202) through buffer springs (203). Slider (206) are fixedly connected to the bottom ends of the two push plates (204) through connecting blocks (205). A drive assembly (207) is connected between the two sliders (206). Each of the push plates (204), connecting blocks (205) and sliders (206) on each side is provided with a lifting component (208), and the back sides of the two clamping plates (202) are fixedly installed with a drive rod (209) and a drive block (210) that can drive the lifting component (208) to operate. The bottom ends of the two sets of lifting components (208) are provided with positioning components (211). The fixed base (201) has symmetrical cavities (201a) on its left and right sides. The drive assembly (207) includes a connecting shaft (207a) rotatably connected to the center of the fixed base (201). Threaded rods (207b) are fixedly installed on both sides of the connecting shaft (207a), and the two threaded rods (207b) are rotatably connected to the two cavities (201a). A rotating rod (207c) is fixedly connected to the left side of the left threaded rod (207b), and the left end of the rotating rod (207c) penetrates the inner wall of the fixed base (201) and extends to its outside, where a knob (207d) is fixedly connected. The outer surfaces of the two threaded rods (207b) are arranged with opposite thread directions, and the two sliders (206) are respectively slidably connected to the outer surfaces of the two threaded rods (207b); A rotating cavity (204a) is provided at the center of the push plate (204), and a second through groove (204b) is provided on the front side of the rotating cavity (204a) and between the push plate (204), the connecting block (205) and the slider (206). A partition plate (213) is fixedly installed in the middle of the cavity (201a). The slider (206) is slidably connected above the partition plate (213). Two sets of positioning racks (214) are symmetrically installed on the front and rear sides of the bottom of the partition plate (213). Each set of positioning racks (214) is composed of multiple triangular blocks (214a). A positioning groove is formed between every two triangular blocks (214a). A third through groove (213a) is opened in the middle of the partition plate (213). The lifting assembly (208) comprises a gear (208a) rotatably connected in the rotating cavity (204a), a L-shaped tooth plate (208b) is engagedly connected to the front side of the gear (208a), a bottom end of the L-shaped tooth plate (208b) extends to the bottom of the second through groove (204b) and is fixedly connected with a inverted T-shaped block (208c), a bottom end of the inverted T-shaped block (208c) penetrates through the third through groove (213a) and extends below the partition plate (213), a vertical plate of the inverted T-shaped block (208c) is slidingly connected in the third through groove (213a), and a horizontal plate is arranged below the partition plate (213) and is in parallel. The gear (208a) is fixedly connected with a hollow rotating drum (208d) at one end close to the clamping plate (202), a helical groove (208e) is formed in the inner wall of the hollow rotating drum (208d), the driving rod (209) is movably inserted into the hollow rotating drum (208d), and the driving block (210) is slidingly connected in the helical groove (208e). The positioning assembly (211) comprises two fixed blocks (211a) fixedly installed on the upper surface of the horizontal plate of the inverted T-shaped block (208c) and located at the front and rear ends, the inner bottom walls of the two fixed blocks (211a) are fixedly connected with two telescopic springs (211b), the top ends of the two telescopic springs (211b) are fixedly connected with two limiting plates (211c), the top end of each limiting plate (211c) is fixedly connected with a trapezoidal block (211d), and the tip of the trapezoidal block (211d) penetrates through the inner top wall of the fixed block (211a) and extends into the positioning groove formed by every two triangular blocks (214a). The plane of the trapezoidal block (211d) is abutted against the plane of one of the triangular blocks (214a), and the inclined surface on the other side of the trapezoidal block (211d) is parallel to the inclined surface of the other triangular block (214a).

2. The new generation of laboratory liquid chromatograph as claimed in claim 1, wherein: The upper surface of the fixed seat (201) is provided with a reagent bottle (102), and the reagent bottle (102) is clamped between the two clamping plates (202).

3. The new generation of laboratory liquid chromatograph as claimed in claim 2, wherein: The opposite surfaces of the two clamping plates (202) are fixedly installed with two buffer pads (212), and the interiors of the two buffer pads (212) are filled with sponges.

4. The new generation of laboratory liquid chromatograph as claimed in claim 3, wherein: The top ends of the two cavities (201a) are provided with first through grooves (201b), the two push plates (204) are slidingly connected to the upper surface of the fixed seat (201) and are located directly above the two first through grooves (201b) respectively, the two connecting blocks (205) are slidingly connected in the two first through grooves (201b) respectively, and the two sliding blocks (206) are slidingly connected in the two cavities (201a) respectively.

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