Veterinary immunopotentiator and preparation method thereof
By combining traditional Chinese medicine compositions with compound amino acids, vitamins, and minerals to prepare veterinary immune enhancers, the problems of insignificant immune effects and severe oxidative damage in existing technologies have been solved, achieving the effects of improving immunity and reducing side effects.
Patent Information
- Application Number
- CN202511085545.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-04
- Publication Date
- 2025-12-05
AI Technical Summary
Existing veterinary immune enhancers struggle to achieve a balance between improving immune efficacy and mitigating oxidative damage side effects, especially in vaccine applications, where there are issues with insufficient immune efficacy and significant oxidative damage.
A veterinary immune enhancer was prepared by combining a traditional Chinese medicine composition (Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos, and Lentinus edodes) with compound amino acids, vitamins, and minerals through water extraction and ethanol extraction. This enhancer promotes the production of immunoglobulins and the function of antigen-presenting cells, and reduces oxidative damage to immune cells.
It significantly increases the production of immunoglobulins, enhances the transformation rate of T lymphocytes, improves livestock immunity, reduces oxidative damage to immune cells, prolongs drug stability and shelf life, and achieves a balance between immune effects and side effects.
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of animal immune enhancer technology, specifically relating to a veterinary immune enhancer and its preparation method. Background Technology
[0002] Immunostimulants are substances that enhance the body's immune response and are widely used in vaccine development, especially in vaccines where improved immunogenicity and efficacy are required. The use of immunostimulants can help vaccines achieve stronger immune effects at lower doses or provide broader-spectrum immune protection against different pathogens.
[0003] Immunostimulants, also known as immune adjuvants, were first researched in the mid-20th century. With advancements in vaccinology and immunology, scientists recognized the complexity of immune responses and the importance of enhancing them. The research and application of immunostimulants have gone through several key stages.
[0004] 1920s: Scientists began preliminary explorations of adjuvants, discovering that adding specific substances (such as mineral oil, live cells, and clay) could enhance the immune effect of vaccines. These substances began to be called "adjuvants." At this time, adjuvants were mainly used to enhance the immune response, especially in avian vaccines.
[0005] 1950s-1960s: With the discovery of aluminum salt adjuvants, scientists found that aluminum salts (such as aluminum hydroxide) could enhance immune responses and began to be widely used in vaccines, especially human vaccines. Aluminum salts promote the sustained release of antigens by adsorbing them and activate the immune system. During this period, the use of aluminum salt adjuvants became routine practice and was widely used in vaccines for hepatitis B, tetanus, and pertussis, forming the basis of adjuvant research.
[0006] 1980s-1990s: Entering the 1980s, the variety of immunostimulants expanded with the research of novel adjuvants such as liposomes and microemulsions. Liposome adjuvants can encapsulate antigens and promote antigen delivery, enhancing immunogenicity. Microemulsion adjuvants can enhance antigen presentation and immune responses at the cellular level. During this period, the focus of adjuvant research began to shift towards more efficient, less toxic adjuvants that can simultaneously activate humoral and cellular immunity.
[0007] From the 2000s to the present: With the development of immunology, molecular biology, and nanotechnology, research on immune enhancers has become increasingly diversified. Researchers have begun to explore more precise immune enhancement strategies, such as novel immune enhancers including nanoparticles, immunomodulatory molecules, and immunostimulatory complexes. Furthermore, to address the specific immune requirements of vaccines, researchers have developed different types of specialized immune enhancers, such as TLR agonists, C-type lectin agonists, and nucleic acid adjuvants, to improve immunization efficacy.
[0008] With the continuous advancement of technology, the development trend of immune enhancers is towards diversification and precision, and the role of immune enhancers in vaccine development is becoming increasingly important. In the future, how to balance the immune effect with the side effects caused by oxidative damage is a technical problem that urgently needs to be solved in this field.
[0009] It should be noted that the information disclosed in this background section is only for understanding the background technology of this application concept, and therefore, the above description is not considered to constitute prior art information. Summary of the Invention
[0010] This disclosure provides at least one veterinary immune enhancer and its preparation method.
[0011] In a first aspect, embodiments of this disclosure provide a veterinary immune enhancer, comprising the following raw materials by weight: 40-50 parts of a traditional Chinese medicine composition, 2-5 parts of a compound amino acid additive, 10-15 parts of a compound vitamin additive, and 2-4 parts of a compound mineral component; wherein the traditional Chinese medicine composition includes Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos, and Lentinus edodes.
[0012] In one optional embodiment, the mass ratio of Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos and Lentinus edodes in the traditional Chinese medicine composition is 2-3:3-5:3-5:2-3:2-3.
[0013] In one alternative embodiment, the compound amino acid additive includes arginine, threonine, and lysine.
[0014] In one optional embodiment, the mass ratio of arginine, threonine, and lysine in the compound amino acid additive is 2-4:2-4:1-2.
[0015] In one alternative embodiment, the multivitamin additive includes vitamin A, vitamin B, vitamin C, vitamin E, and vitamin K.
[0016] In one optional embodiment, the mass ratio of vitamin A, vitamin B, vitamin C, vitamin E and vitamin K in the compound vitamin additive is 1-2:2-3:5-8:1-2:1-2.
[0017] In one alternative embodiment, the composite mineral components include iron, magnesium, zinc, selenium, and calcium.
[0018] In one optional embodiment, the mass ratio of iron, magnesium, zinc, selenium and calcium in the composite mineral component is 8-12:5-6:5-6:0.5-1:1-2.
[0019] Secondly, this disclosure also provides a method for preparing the veterinary immune enhancer as described above, comprising: mixing a traditional Chinese medicine composition, a compound amino acid additive, a compound vitamin additive, and a compound mineral in a certain proportion to obtain the veterinary immune enhancer.
[0020] In an optional embodiment, the preparation method of the traditional Chinese medicine composition includes the following steps: S1, mixing Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos, and Lentinus edodes evenly, adding 4-6 times the volume of distilled water, and extracting with water at 90-100°C for 1-2 hours to obtain an extracted filtrate and a filter residue; S2, adding 5-6 times the volume of ethanol to the filter residue obtained in step S1 and extracting for 1-2 hours to obtain an ethanol extract; S3, mixing the filtrate obtained in step S1 and the ethanol extract obtained in step S2, concentrating, and drying at 50-60°C to obtain a powdered traditional Chinese medicine composition.
[0021] The beneficial effects of this invention are that the veterinary immune enhancer and its preparation method, by adding a traditional Chinese medicine composition, can significantly increase the production of immunoglobulins and promote the interaction between antigen-presenting cells and T lymphocytes, thereby increasing the T lymphocyte transformation rate and improving the immunity of livestock. At the same time, by adding compound vitamin additives, it can eliminate free radicals in the body, reduce oxidative damage to immune cells, delay the oxidation process of drug and vaccine components, and improve the stability and shelf life of drugs, thus achieving a balance between immune effects and side effects.
[0022] Other features and advantages of the invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. The objects and other advantages of the invention are realized and obtained through the structures particularly pointed out in the description.
[0023] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, preferred embodiments are described in detail below. Detailed Implementation
[0024] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0025] As used herein, the phrases “in one embodiment,” “according to one embodiment,” “in some embodiments,” etc., generally refer to the fact that a particular feature, structure, or characteristic following the phrase can be included in at least one embodiment of this disclosure. Therefore, a particular feature, structure, or characteristic can be included in more than one embodiment of this disclosure, such that these phrases do not necessarily refer to the same embodiment. As used herein, the terms “example,” “exemplary,” etc., are used to “serve as an example, instance, or illustration.” Any implementation, aspect, or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or superior to other implementations, aspects, or designs. Rather, the use of the terms “example,” “exemplary,” etc., is intended to present concepts in a specific manner.
[0026] In this document, as used herein, expressions such as “at least one of…” modify the entire list of elements when following a list of elements, rather than individual elements in the list. For example, the expression “at least one of a, b, and c” should be understood to include only a, only b, only c, both a and b, both a and c, both b and c, or all of a, b, and c.
[0027] The terminology used herein is for the purpose of describing specific exemplary configurations only and is not intended to be limiting. As used herein, the singular articles “a,” “an,” and “the” may also be intended to include plural forms unless otherwise clearly stated herein. The terms “comprising,” “including,” and “having” are inclusive and thus specify the presence of features, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or combinations thereof. The method steps, processes, and operations described herein should not be construed as requiring them to be performed in the specific order discussed or shown, unless specifically identified as such. Additional or alternative steps may be employed.
[0028] The following describes some embodiments of the present invention in detail. Unless otherwise specified, the following embodiments and features can be combined with each other.
[0029] This disclosure provides a veterinary immune enhancer, comprising the following raw materials by weight: 40-50 parts of a traditional Chinese medicine composition, 2-5 parts of a compound amino acid additive, 10-15 parts of a compound vitamin additive, and 2-4 parts of a compound mineral component; wherein the traditional Chinese medicine composition includes Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos, and Lentinus edodes.
[0030] In some embodiments, specifically, the mass ratio of Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos and Lentinus edodes in the traditional Chinese medicine composition is 2-3:3-5:3-5:2-3:2-3.
[0031] In some embodiments, specifically, the compound amino acid additive includes arginine, threonine, and lysine, which can promote protein synthesis and repair, enhance the function of immune cells such as T cells and B cells, and improve the body's ability to fight pathogens.
[0032] In some embodiments, specifically, the mass ratio of arginine, threonine, and lysine in the composite amino acid additive is 2-4:2-4:1-2.
[0033] In some embodiments, specifically, the multivitamin additive includes vitamin A, vitamin B, vitamin C, vitamin E, and vitamin K.
[0034] In some embodiments, specifically, the mass ratio of vitamin A, vitamin B, vitamin C, vitamin E and vitamin K in the compound vitamin additive is 1-2:2-3:5-8:1-2:1-2.
[0035] In some embodiments, the complex mineral components specifically include iron, magnesium, zinc, selenium, and calcium, wherein zinc, selenium, and iron are essential for the normal function of the immune system. Zinc and selenium are important trace elements in the immune system, which can promote the function of T cells and B cells and enhance the body's immune response. Magnesium and calcium help improve the absorption or binding of vaccines in the intestine, thereby increasing the utilization of antigens in adjuvants and enhancing immune efficacy.
[0036] In some embodiments, specifically, the mass ratio of iron, magnesium, zinc, selenium and calcium in the composite mineral component is 8-12:5-6:5-6:0.5-1:1-2.
[0037] This disclosure also provides a method for preparing the veterinary immune enhancer as described above, comprising: mixing a traditional Chinese medicine composition, a compound amino acid additive, a compound vitamin additive, and a compound mineral in a certain proportion to obtain the veterinary immune enhancer.
[0038] In some embodiments, the specific preparation method of the traditional Chinese medicine composition includes the following steps: S1, mixing Astragalus membranaceus, Quercus serrata bark, Rheum palmatum, Poria cocos, and Lentinus edodes evenly, adding 4-6 times the volume of distilled water, and extracting with water at 90-100°C for 1-2 hours to obtain an extracted filtrate and a filter residue; S2, adding 5-6 times the volume of ethanol to the filter residue obtained in step S1 and extracting for 1-2 hours to obtain an ethanol extract; S3, mixing the filtrate obtained in step S1 and the ethanol extract obtained in step S2, concentrating, and drying at 50-60°C to obtain a powdered traditional Chinese medicine composition. Example
[0039] A veterinary compound immune enhancer is formulated from the following raw materials in the indicated weight proportions: The raw materials of the traditional Chinese medicine composition include: Astragalus membranaceus 66.6g, Quercus bark 100.0g, Rheum palmatum 100.0g, Poria cocos 66.6g, and Shiitake mushroom 66.6g.
[0040] The compound amino acid additive includes: 8.0g arginine, 8.0g threonine, and 2.0g lysine.
[0041] The multivitamin supplement includes: Vitamin A 10.0g, Vitamin B 20.0g, Vitamin C 50.0g, Vitamin E 10.0g, and Vitamin K 10.0g.
[0042] The compound minerals include: 8.2g iron, 5.1g magnesium, 5.1g zinc, 0.5g selenium, and 1.0g calcium.
[0043] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Mix Astragalus membranaceus, Quercus bark, Rheum palmatum, Poria cocos, and Shiitake mushroom evenly, add 4-6 times the volume of distilled water, and extract with water at 90-100℃ for 1-2 hours. Repeat the water extraction twice to obtain the extracted filtrate and residue. (2) Add 5-6 times the volume of ethanol to the filter residue obtained in step (1) and extract for 1-2 hours to obtain ethanol extract; (3) The filtrate obtained in step (1) and the ethanol extract obtained in step (2) are mixed, concentrated, and dried at 50-60°C to obtain a powdered traditional Chinese medicine composition.
[0044] The traditional Chinese medicine composition, compound amino acid additive, compound vitamin additive, and compound mineral are mixed evenly in a certain proportion to obtain the aforementioned veterinary compound immune enhancer. Example
[0045] A veterinary compound immune enhancer is formulated from the following raw materials in the indicated weight proportions: The raw materials of the traditional Chinese medicine composition include: Astragalus membranaceus 83.3g, Quercus scutellaria barbata 125.0g, Rheum palmatum 125.0g, Poria cocos 83.3g, and Lentinus edodes 83.3g.
[0046] The compound amino acid additive includes: 20.0g arginine, 20.0g threonine, and 10.0g lysine.
[0047] The multivitamin supplement includes: Vitamin A 15.0g, Vitamin B 30.0g, Vitamin C 75.0g, Vitamin E 15.0g, and Vitamin K 15.0g. The compound minerals include: 16.4g iron, 10.2g magnesium, 10.2g zinc, 1.0g selenium, and 10g calcium.
[0048] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Mix Astragalus membranaceus, Quercus bark, Rheum palmatum, Poria cocos, and Shiitake mushroom evenly, add 4-6 times the volume of distilled water, and extract with water at 90-100℃ for 1-2 hours. Repeat the water extraction twice to obtain the extracted filtrate and residue. (2) Add 5-6 times the volume of ethanol to the filter residue obtained in step (1) and extract for 1-2 hours to obtain ethanol extract; (3) The filtrate obtained in step (1) and the ethanol extract obtained in step (2) are mixed, concentrated, and dried at 50-60°C to obtain a powdered traditional Chinese medicine composition.
[0049] The traditional Chinese medicine composition, compound amino acid additive, compound vitamin additive, and compound mineral are mixed evenly in a certain proportion to obtain the aforementioned veterinary compound immune enhancer. Example
[0050] A veterinary compound immune enhancer is formulated from the following raw materials in the indicated weight proportions: The raw materials of the traditional Chinese medicine composition include: Astragalus membranaceus 63.1g, Quercus scutellaria barbata 105.2g, Rheum palmatum 105.2g, Poria cocos 63.1g, and Lentinus edodes 63.1g.
[0051] The compound amino acid additive includes: 8.0g arginine, 8.0g threonine, and 2.0g lysine.
[0052] The multivitamin supplement includes: Vitamin A 11.7g, Vitamin B 17.6g, Vitamin C 29.4g, Vitamin E 11.7g, and Vitamin K 11.7g.
[0053] The complex minerals include: 8.8g iron, 4.4g magnesium, 4.4g zinc, 0.7g selenium, and 1.5g calcium.
[0054] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Mix Astragalus membranaceus, Quercus bark, Rheum palmatum, Poria cocos, and Shiitake mushroom evenly, add 4-6 times the volume of distilled water, and extract with water at 90-100℃ for 1-2 hours. Repeat the water extraction twice to obtain the extracted filtrate and residue. (2) Add 5-6 times the volume of ethanol to the filter residue obtained in step (1) and extract for 1-2 hours to obtain ethanol extract; (3) The filtrate obtained in step (1) and the ethanol extract obtained in step (2) are mixed, concentrated, and dried at 50-60°C to obtain a powdered traditional Chinese medicine composition.
[0055] The traditional Chinese medicine composition, compound amino acid additive, compound vitamin additive, and compound mineral are mixed evenly in a certain proportion to obtain the aforementioned veterinary compound immune enhancer. Example
[0056] A veterinary compound immune enhancer is formulated from the following raw materials in the indicated weight proportions: The raw materials of the traditional Chinese medicine composition include: Astragalus membranaceus 78.9g, Quercus scutellaria barbata 131.5g, Rheum palmatum 131.5g, Poria cocos 78.9g, and Lentinus edodes 78.9g.
[0057] The compound amino acid additive includes: 20.0g arginine, 20.0g threonine, and 10.0g lysine.
[0058] The multivitamin supplement includes: Vitamin A 17.6g, Vitamin B 26.4g, Vitamin C 44.1g, Vitamin E 17.6g, and Vitamin K 17.6g.
[0059] The complex minerals include: 17.6g iron, 8.8g magnesium, 8.8g zinc, 1.4g selenium, and 3.0g calcium.
[0060] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Mix Astragalus membranaceus, Quercus bark, Rheum palmatum, Poria cocos, and Shiitake mushroom evenly, add 4-6 times the volume of distilled water, and extract with water at 90-100℃ for 1-2 hours. Repeat the water extraction twice to obtain the extracted filtrate and residue. (2) Add 5-6 times the volume of ethanol to the filter residue obtained in step (1) and extract for 1-2 hours to obtain ethanol extract; (3) The filtrate obtained in step (1) and the ethanol extract obtained in step (2) are mixed, concentrated, and dried at 50-60°C to obtain a powdered traditional Chinese medicine composition.
[0061] The traditional Chinese medicine composition, compound amino acid additive, compound vitamin additive, and compound mineral are mixed evenly in a certain proportion to obtain the aforementioned veterinary compound immune enhancer.
[0062] Thirty-six 6-8 week old SPF-grade female Kunming mice were selected for the experiment and randomly divided into five groups: a blank control group, Example 1 group, Example 2 group, Example 3 group, and Example 4 group, with 10 mice in each group. The immune enhancers for Example 1, Example 2, Example 3, and Example 4 groups were dissolved in an equal volume of water, and approximately 0.2 mL of the immune enhancer was injected intraperitoneally into each mouse in each group. The blank control group was injected intraperitoneally with an equal volume of physiological saline. After 14 days, the mice were euthanized by cervical dislocation. The thymus and spleen were dissected, the surface blood was aspirated, and the wet weight was measured using an electronic balance. The thymus and spleen indices were calculated, and the results are shown in Table 1.
[0063] In addition, the proliferation activity of splenic lymphocytes was determined as follows: Spleen cells were aseptically harvested and washed with 3 mL of pre-cooled PBS buffer containing 1% penicillin-antibody until the spleen turned white. The washing solution was collected in 5 mL centrifuge tubes and centrifuged at 1500 rpm for 10 min. The supernatant was discarded, and 2 mL of erythrocyte lysis buffer was added to each tube to resuspend the cells. After standing for 3 min, the cells were centrifuged at 1500 rpm for 10 min. The cells were washed twice with 1% penicillin-antibody PBS. The cells were resuspended in 1640 buffer containing 1% penicillin-antibody. The cell concentration was adjusted to 500,000 cells / mL. Six wells of a 96-well plate were selected and 200 μL of PBS was added as a blank control group. The remaining wells were added with 100 μL of cell suspension. The intervention group was added with 100 μL of the drugs from Examples 1, 2, 3, and 4. The blank control group was added with 100 μL of culture medium. Each group was divided into three replicates. The cells were incubated at 37°C for 72 h. Four hours before the end of the culture, add 10 μL of 5 mg / mL MTT solution to each well of the culture plate. Incubate at 37℃ for 4 hours. Centrifuge at 1500 rpm for 10 min, discard the supernatant, add 150 μL of DMSO to each well, dissolve for 10 min, and measure the absorbance (OD) at 490 nm using a microplate reader within 30 min. The results are shown in Table 2.
[0064] Table 1 Immune organ indices for each group
[0065] As can be seen from the experimental results in Table 1, the thymus and spleen indices of each embodiment group were higher than those of the blank control group, indicating that the veterinary compound immune enhancer prepared in this invention can effectively improve the immune organ indices of mice.
[0066] Table 2 Comparison of splenic lymphocyte proliferation activity among groups
[0067] The experimental results in Table 2 show that after induction with the veterinary compound immune enhancer, the activity of spleen lymphocytes was enhanced, and the extract group was significantly higher than that of the blank control. This indicates that the problem of oxidative damage to immune cells has been improved, and the goal of enhancing immunity and reducing side effects has been achieved.
[0068] In summary, this veterinary immune enhancer and its preparation method, by incorporating a traditional Chinese medicine composition, can significantly increase the production of immunoglobulins and promote the interaction between antigen-presenting cells and T lymphocytes, thereby increasing the T lymphocyte transformation rate and enhancing the immunity of livestock. Simultaneously, by adding compound vitamin additives, it can scavenge free radicals in the body, reduce oxidative damage to immune cells, delay the oxidation process of drug and vaccine components, and improve the stability and shelf life of the drug, thus achieving a balance between immune efficacy and side effects.
[0069] Based on the above-described preferred embodiments of the present invention, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the inventive concept. The technical scope of this invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.
Claims
1. A veterinary immune enhancer, characterized in that, The following raw materials are included by weight parts: Chinese medicine composition 40-50 parts, complex amino acid additive 2-5 parts, complex vitamin additive 10-15 parts, and complex mineral component 2-4 parts. The Chinese medicine composition includes Radix Astragali, Quercus, Rhubarb, Poria cocos, and Lentinus edodes.
2. The veterinary immunopotentiator of claim 1, wherein The mass ratio of Radix Astragali, Quercus, Rhubarb, Poria cocos, and Lentinus edodes in the Chinese medicine composition is 2-3:3-5:3-5:2-3:2-3.
3. The veterinary immunopotentiator of claim 1, wherein The complex amino acid additive includes arginine, threonine, and lysine.
4. The veterinary immunopotentiator of claim 3, wherein The mass ratio of arginine, threonine, and lysine in the complex amino acid additive is 2-4:2-4:1-2.
5. The veterinary immunopotentiator of claim 1, wherein The complex vitamin additive includes vitamin A, vitamin B, vitamin C, vitamin E, and vitamin K.
6. The veterinary immunopotentiator of claim 5, wherein The mass ratio of vitamin A, vitamin B, vitamin C, vitamin E, and vitamin K in the complex vitamin additive is 1-2:2-3:5-8:1-2:1-2.
7. The veterinary immunopotentiator of claim 1, wherein The complex mineral component includes iron, magnesium, zinc, selenium, and calcium.
8. The veterinary immunopotentiator of claim 7, wherein The mass ratio of iron, magnesium, zinc, selenium, and calcium in the complex mineral component is 8-12:5-6:5-6:0.5-1:1-2.
9. A method for the preparation of the veterinary immunopotentiator according to any one of claims 1 to 7, characterized in that, The method comprises the following steps: The Chinese medicine composition, the complex amino acid additive, the complex vitamin additive, and the complex mineral component are mixed uniformly in proportion to obtain the veterinary immunopotentiator.
10. The production method according to claim 9, wherein The preparation method of the Chinese medicine composition comprises the following steps: S1. Radix Astragali, Quercus, Rhubarb, Poria cocos, and Lentinus edodes are mixed uniformly, 4-6 times the volume of distilled water is added, and water extraction is performed at 90-100°C for 1-2 hours to obtain a filtrate and a residue; S2. 5-6 times the volume of ethanol is added to the residue obtained in step S1, and extraction is performed for 1-2 hours to obtain an ethanol extract; S3. The filtrate obtained in step S1 and the ethanol extract obtained in step S2 are mixed, concentrated, and dried at 50-60°C to obtain a powder-shaped Chinese medicine composition.