Preparation method of nutrition intervention agent for diabetes and complications thereof based on plant extracts

Abstract

The invention relates to the technical field of biological products, and discloses a preparation method of a nutrition intervention agent for diabetes and complications thereof based on plant extracts. Comprising the following raw materials by weight: 25%-30% of a balsam pear extract, 15%-25% of a wolfberry extract, 10%-15% of a green tea extract, 9%-12% of a polygonatum sibiricum extract, 5%-10% of a ganoderma lucidum extract, 5%-7% of a salvia miltiorrhiza extract, 5%-7% of an astragalus membranaceus extract, 4%-5% of a lycium ruthenicum extract, and 5%-8% of a garlic extract. According to the nutrition intervention agent, the plant extracts such as the bitter gourd extract, the fructus lycii extract and the rhizoma polygonati extract contained in the nutrition intervention agent can effectively reduce the blood sugar level and help diabetic patients to control blood sugar fluctuation by adjusting insulin secretion, improving insulin resistance and other mechanisms.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological products, in particular to a preparation method of a nutritional intervention agent for diabetes and its complications based on plant extracts. BACKGROUND

[0002] In order to further improve the application effect of plant extracts in the treatment of diabetes, researchers are constantly exploring the function and preparation technology of new plant extracts. Especially in the treatment of diabetes and its complications, how to play a synergistic effect through reasonable combination of plant extracts to further improve its curative effect has become an important direction of current research. Plant extracts can not only reduce blood sugar by regulating insulin secretion, improving insulin resistance and other mechanisms, but also protect the body from multiple complications caused by diabetes through antioxidant and anti-inflammatory effects.

[0003] In terms of preparation technology, the development of modern science and technology provides more possibilities for the extraction of effective components of plant extracts. For example, the application of new technologies such as supercritical fluid extraction technology, freeze-drying technology and nanotechnology can not only improve the purity and bioavailability of plant extracts, but also better maintain the stability of plant active ingredients. The application of these new preparation processes will make the effect of plant extracts in the treatment of diabetes more significant.

[0004] By combining plant extracts with conventional treatment methods, a more comprehensive and personalized treatment plan can be provided for diabetes patients, so the development of nutritional intervention agents for diabetes and its complications based on plant extracts has become the focus of research.

[0005] Therefore, we propose a preparation method of a nutritional intervention agent for diabetes and its complications based on plant extracts. SUMMARY

[0006] The present application mainly solves the technical problems existing in the prior art and provides a preparation method of a nutritional intervention agent for diabetes and its complications based on plant extracts.

[0007] In order to achieve the above purpose, the present application adopts the following technical scheme: the diabetes based on plant extracts comprises the following raw materials by weight: bitter gourd extract 25%-30%, medlar extract 15%-25%, green tea extract 10%-15%, polygonatum extract 9%-12%, ganoderma extract 5%-10%, salvia miltiorrhiza extract 5%-7%, astragalus extract 5%-7%, black medlar extract 4%-5%, and garlic extract 5%-8%.

[0008] The preparation method of the diabetes complication nutritional intervention agent based on plant extracts specifically includes the following steps: S1: raw material preparation, according to the formula, the bitter gourd extract, medlar extract, green tea extract, yellow ginseng extract, ganoderma lucidum extract, salvia miltiorrhiza extract, radix astragali extract, black medlar extract, garlic extract are weighed according to the mass fraction respectively;

[0009] S2: plant material selection and treatment, select high-quality plant raw materials meeting the GMP standard, all plant raw materials need to be cleaned, impurities are removed and then placed in a ventilated place, and placed at room temperature for 12 hours for natural air drying;

[0010] S3: crushing and drying treatment, the treated plant material is crushed, and the crushed plant material is dried by using low-temperature vacuum drying technology, so as to remove water without destroying the effective components of the plant, and the dried plant material should maintain the stability of the active ingredients;

[0011] S4: soaking and extraction, the treated plant material is soaked with 60%-90% ethanol solution at a ratio of 1:10, the soaking time is 24 hours, and the plant material is stirred every 6 hours to ensure that the effective components of the plant are fully dissolved, in order to improve the extraction efficiency, ultrasonic extraction method is adopted;

[0012] S5: concentration and drying, the extract is concentrated by a rotary evaporator to remove the ethanol solvent and obtain a concentrated solution, the concentrated liquid is further dried by vacuum drying method to obtain dry powder of plant extract, and the dry powder should retain the main active ingredients in each plant, such as momorcharin in bitter gourd extract, polysaccharide in medlar, tea polyphenol in green tea, saponin in yellow ginseng, polysaccharide in ganoderma lucidum, tanshinone in salvia miltiorrhiza extract, astragalus polysaccharide in radix astragali extract, anthocyanin in black medlar extract, and allicin in garlic extract;

[0013] S6: active ingredient identification and standardization, the main active ingredients in the extract are qualitatively and quantitatively analyzed by high performance liquid chromatography method, so as to ensure that the content of active ingredients of each extract meets the standard requirements, for example, the contents of momorcharin, medlar polysaccharide, tea polyphenol, yellow ginseng saponin, ganoderma lucidum polysaccharide, tanshinone, astragalus polysaccharide, black medlar anthocyanin and allicin are determined, and each component meets the efficacy standard required for treating diabetes;

[0014] S7: biological activity detection, the biological activity of each plant extract is verified by cell culture method and animal experiment, for example, the blood glucose changes of diabetes model animals are tested by using a blood glucose meter, and the antioxidant effect is detected by using superoxide dismutase activity determination method, so as to verify the hypoglycemic and antioxidant effects of each extract;

[0015] S8: Formulation design and preparation, mix the plant extracts according to the proportions in S1, add appropriate amount of gelatin, ensure uniform distribution of each component, and avoid inactivation of active ingredients;

[0016] S9: Wet granulation and drying, when wet granulation, add appropriate amount of wetting agent, wet the mixture to the appropriate degree for granulation, ensure uniform drying of the granules, and avoid the influence of wet granules on product quality;

[0017] S10: Packaging and storage, the finished product is packaged by automatic packaging line, and aluminum foil bag or bottle is used to ensure the hygiene and safety of the product. During the packaging process, strict GMP requirements should be followed to avoid cross contamination and other safety hazards.

[0018] As preferred, in the S3, the particle size of the crushed powder is 0.5 mm.

[0019] As preferred, in the S4, the ultrasonic power is set to 500 W, the frequency is 40 kHz, the temperature is controlled at 30-45℃, and the extraction time is 1 hour.

[0020] As preferred, in the S9, the wet granules are dried at 40-55℃ for 1 hour.

[0021] The present application provides a preparation method of a plant extract-based nutritional intervention agent for diabetes and its complications.

[0022] 1. The preparation method of the plant extract-based nutritional intervention agent for diabetes and its complications, the plant extracts contained in the nutritional intervention agent, such as bitter gourd extract, medlar extract, and polygonatum extract, can effectively reduce blood glucose level by regulating insulin secretion and improving insulin resistance, and help diabetes patients control blood glucose fluctuation.

[0023] 2. The preparation method of the plant extract-based nutritional intervention agent for diabetes and its complications, the plant extracts, such as tea polyphenols in green tea extract and anthocyanins in black medlar extract, have strong antioxidant activity, can reduce the damage of free radicals to the body, and reduce the oxidative stress caused by diabetes, thereby slowing down the occurrence of diabetes-related complications.

[0024] 3. The preparation method of the plant extract-based nutritional intervention agent for diabetes and its complications, various plant extracts such as ganoderma lucidum extract and salvia miltiorrhiza extract have significant anti-inflammatory effect, can inhibit chronic inflammatory reaction caused by diabetes, thereby reducing the inflammatory burden of diabetes patients and helping to improve the risk of diabetes complications such as cardiovascular disease.

[0025] 4、The preparation method of the diabetes and its complications nutritional intervention agent based on plant extracts, such as tanshinone contained in Danshen extract, astragalus polysaccharide contained in astragalus extract, etc., has the effects of improving blood circulation and enhancing microvascular function, and can alleviate the common blood circulation problems of diabetic patients, such as poor peripheral blood circulation, diabetic foot ulcers, etc.

[0026] 5、The preparation method of the diabetes and its complications nutritional intervention agent based on plant extracts, the effective components in wolfberry extract, astragalus extract and ganoderma extract have the effect of enhancing the immune system. By regulating the function of immune cells, the immunity of diabetic patients can be improved, which helps them resist infection and other complications and improves the overall health status. DETAILED DESCRIPTION

[0027] In order to make the invention purposes, features and advantages of the present application more obvious and easy to understand, the technical solutions in the embodiments of the present application are described clearly and completely. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0028] Embodiment one: diabetes based on plant extracts, including the following raw materials by weight: bitter gourd extract: 25%, wolfberry extract: 20%, green tea extract: 15%, Huangjing extract: 10%, Ganoderma extract: 8%, Danshen extract: 7%, Huangqi extract: 5%, black wolfberry extract: 5%, garlic extract: 5%;

[0029] The preparation method of the diabetes and its complications nutritional intervention agent based on plant extracts, specifically includes the following steps:

[0030] S1: raw material preparation

[0031] According to the formula, bitter gourd extract, wolfberry extract, green tea extract, Huangjing extract, Ganoderma extract, Danshen extract, Huangqi extract, black wolfberry extract and garlic extract are weighed by mass fraction respectively;

[0032] S2: plant material selection and treatment

[0033] Select high-quality plant raw materials that meet the GMP standard. All plant raw materials need to be cleaned, impurities removed and placed in a ventilated place at room temperature for 12h natural air drying;

[0034] S3: crushing and drying treatment

[0035] The processed plant material is crushed into a powder with a particle size of 0.5 mm, and the crushed plant material is dried using low-temperature vacuum drying technology to remove moisture without damaging the active ingredients of the plant, and the dried plant material should maintain the stability of the active ingredients;

[0036] S4: Soaking and extraction

[0037] The processed plant material is soaked in a 60% ethanol solution at a ratio of 1:10 for 24 hours, and stirred every 6 hours to ensure that the active ingredients of the plant are fully dissolved. To improve extraction efficiency, ultrasonic extraction is used with a power of 500W, a frequency of 40kHz, and a temperature control of 30°C for 1 hour;

[0038] S5: Concentration and drying

[0039] The extract is concentrated by rotary evaporation to remove the ethanol solvent, and the concentrated liquid is further dried by vacuum drying to obtain a dry powder of the plant extract. The dry powder should retain the main active ingredients of each plant, such as momorcharin in bitter gourd extract, polysaccharide in wolfberry, tea polyphenol in green tea, saponin in polygonatum, polysaccharide in ganoderma lucidum, tanshinone in salvia miltiorrhiza extract, astragalus polysaccharide in astragalus extract, anthocyanin in black wolfberry extract, and allicin in garlic extract;

[0040] S6: Active ingredient identification and standardization

[0041] The main active ingredients in the extract are qualitatively and quantitatively analyzed by high-performance liquid chromatography to ensure that the content of each active ingredient in the extract meets the standard requirements. For example, the content of momorcharin, wolfberry polysaccharide, tea polyphenol, polygonatum saponin, ganoderma lucidum polysaccharide, tanshinone, astragalus polysaccharide, black wolfberry anthocyanin, and allicin is determined to ensure that each component meets the pharmacodynamic standard required for the treatment of diabetes;

[0042] S7: Biological activity detection

[0043] The biological activity of each plant extract is verified by cell culture and animal experiments. For example, the blood glucose changes of diabetic model animals are tested using a blood glucose meter, and the antioxidant effect is detected by superoxide dismutase activity determination to verify the hypoglycemic and antioxidant effects of each extract;

[0044] S8: Formula design and deployment

[0045] The plant extracts are mixed according to the proportions in S1, and an appropriate amount of gelatin is added to ensure uniform distribution of each component and to prevent inactivation of the active ingredients;

[0046] S9: Wet granulation and drying

[0047] When wet granulation is used, a suitable amount of wetting agent is added to wet the mixture to a suitable degree for granulation, and the wet granules are dried by drying at 40°C for 1 hour to ensure uniform drying of the granules and avoid the influence of wet granules on product quality due to incomplete drying;

[0048] S10: Packaging and storage

[0049] The finished product is packaged by an automatic packaging line, and is packaged in moisture-proof and light-proof aluminum foil bags or bottles to ensure the hygiene and safety of the product. During the packaging process, strict compliance with GMP requirements is ensured to avoid cross-contamination and other safety hazards.

[0050] Example Two: Diabetes based on plant extracts, including the following raw materials by weight: bitter gourd extract: 20%, wolfberry extract: 25%, green tea extract: 10%, Huangjing extract: 12%, Lingzhi extract: 8%, Danshen extract: 6%, Huangqi extract: 6%, black wolfberry extract: 5%, garlic extract: 8%;

[0051] The above method for preparing the diabetes complication nutritional intervention agent based on plant extracts specifically includes the following steps:

[0052] S1: Raw material preparation

[0053] According to the formula, the bitter gourd extract, wolfberry extract, green tea extract, Huangjing extract, Lingzhi extract, Danshen extract, Huangqi extract, black wolfberry extract, and garlic extract are weighed according to the mass fraction;

[0054] S2: Plant material selection and treatment

[0055] High-quality plant raw materials meeting GMP standards are selected, all plant raw materials are cleaned and impurities are removed, and then placed in a well-ventilated place at room temperature for 12 hours of natural air drying;

[0056] S3: Crushing and drying treatment

[0057] The treated plant material is crushed to a particle size of 0.5 mm, and low-temperature vacuum drying technology is used to dry the crushed plant material to ensure that the water is removed without damaging the active ingredients of the plant, and the dried plant material should maintain the stability of the active ingredients;

[0058] S4: Soaking and extraction

[0059] The treated plant material is soaked with 70% ethanol solution at a ratio of 1:10 for 24 hours, and stirred every 6 hours to ensure sufficient dissolution of the plant active ingredients. To improve the extraction efficiency, ultrasonic extraction is used, with a power of 500 W, a frequency of 40 kHz, a temperature of 35°C, and an extraction time of 1 hour.

[0060] S5: Concentration and drying

[0061] The extract is concentrated by rotary evaporation to remove the ethanol solvent, obtaining a concentrated solution. The concentrated solution is further dried by vacuum drying to obtain a dry powder of plant extract. The dry powder should retain the main active ingredients of each plant, such as momorcharin in bitter gourd extract, polysaccharide in wolfberry, tea polyphenol in green tea, saponin in polygonatum, polysaccharide in ganoderma, tanshinone in salvia miltiorrhiza extract, astragalus polysaccharide in astragalus extract, anthocyanin in black wolfberry extract, and allicin in garlic extract.

[0062] S6: Active ingredient identification and standardization

[0063] The main active ingredients in the extract are qualitatively and quantitatively analyzed by high-performance liquid chromatography to ensure that the content of active ingredients in each extract meets the standard requirements. For example, the content of momorcharin, wolfberry polysaccharide, tea polyphenol, polygonatum saponin, ganoderma polysaccharide, tanshinone, astragalus polysaccharide, black wolfberry anthocyanin, and allicin is determined to ensure that each component meets the pharmacodynamic standard required for the treatment of diabetes.

[0064] S7: Biological activity detection

[0065] The biological activity of each plant extract is verified by cell culture and animal experiments. For example, the blood glucose changes of diabetic model animals are tested using a blood glucose meter, and the antioxidant effect is detected by superoxide dismutase activity determination to verify the hypoglycemic and antioxidant effects of each extract.

[0066] S8: Formula design and preparation

[0067] The plant extracts are mixed according to the ratio in S1, and an appropriate amount of gelatin is added to ensure uniform distribution of each component and avoid inactivation of active ingredients.

[0068] S9: Wet granulation and drying

[0069] During wet granulation, an appropriate amount of wetting agent is added to wet the mixture to a suitable degree for granulation. The wet granules are dried at 45°C for 1 hour to ensure uniform drying and avoid the impact of wet granules on product quality.

[0070] S10: Packaging and storage

[0071] The finished product is packaged by an automatic packaging line, using moisture-proof and light-proof aluminum foil bags or bottles to ensure the hygiene and safety of the product. During packaging, strict GMP requirements are followed to avoid cross-contamination and other safety hazards.

[0072] Example Three: Diabetes based on plant extracts, including the following raw materials by weight: bitter gourd extract: 30%, medlar extract: 15%, green tea extract: 12%, polygonatum extract: 10%, ganoderma extract: 8%, salvia miltiorrhiza extract: 5%, astragalus extract: 7%, black medlar extract: 5%, garlic extract: 8%;

[0073] The above method for preparing a diabetes complication nutritional intervention agent based on plant extracts specifically includes the following steps:

[0074] S1: Raw material preparation

[0075] According to the formula, bitter gourd extract, medlar extract, green tea extract, polygonatum extract, ganoderma extract, salvia miltiorrhiza extract, astragalus extract, black medlar extract, and garlic extract are weighed out according to the mass fraction;

[0076] S2: Plant material selection and treatment

[0077] High-quality plant raw materials that meet GMP standards are selected. All plant raw materials are cleaned, decontaminated, and then placed in a well-ventilated area at room temperature for 12 hours of natural air drying.

[0078] S3: Crushing and drying treatment

[0079] The treated plant material is crushed into a powder with a particle size of 0.5 millimeters. Low-temperature vacuum drying technology is used to dry the crushed plant material, ensuring that moisture is removed without damaging the active ingredients of the plant. The dried plant material should maintain the stability of the active ingredients.

[0080] S4: Soaking and extraction

[0081] The treated plant material is soaked with 80% ethanol solution at a ratio of 1:10 for 24 hours, with stirring every 6 hours to ensure the complete dissolution of the plant active ingredients. To improve extraction efficiency, ultrasonic extraction is used with an ultrasonic power of 500W, a frequency of 40kHz, and a temperature control of 40°C. The extraction time is 1 hour.

[0082] S5: Concentration and drying

[0083] The extract is concentrated by a rotary evaporator to remove the ethanol solvent, obtaining a concentrated liquid. The concentrated liquid is further dried by a vacuum drying method to remove excess water, obtaining a dry powder of the plant extract. The dry powder should retain the main active ingredients in each plant, such as momorcharin in bitter gourd extract, polysaccharide in medlar, tea polyphenol in green tea, saponin in polygonatum, polysaccharide in ganoderma, tanshinone in salvia miltiorrhiza extract, astragalus polysaccharide in astragalus extract, anthocyanin in black medlar extract, and allicin in garlic extract.

[0084] S6: Active ingredient identification and standardization

[0085] The main active ingredients in the extract are qualitatively and quantitatively analyzed by high-performance liquid chromatography to ensure that the active ingredient content of each extract meets the standard requirements. For example, the contents of momorcharin, medlar polysaccharide, tea polyphenol, polygonatum saponin, ganoderma polysaccharide, tanshinone, astragalus polysaccharide, black medlar anthocyanin, and allicin are determined to ensure that each component meets the pharmacodynamic standard required for the treatment of diabetes.

[0086] S7: Biological activity detection

[0087] The biological activity of each plant extract is verified by cell culture method and animal experiment. For example, the blood glucose changes of diabetic model animals are tested using a blood glucose meter, and the antioxidant effect is detected by superoxide dismutase activity determination method to verify the hypoglycemic and antioxidant effects of each extract.

[0088] S8: Formula design and preparation

[0089] The plant extracts are mixed according to the proportions in S1, and an appropriate amount of gelatin is added to ensure uniform distribution of each component and avoid inactivation of the active ingredients.

[0090] S9: Wet granulation and drying

[0091] During wet granulation, an appropriate amount of wetting agent is added to wet the mixture to a suitable degree for granulation. The wet granules are dried at 50°C for 1 hour to ensure uniform drying and avoid the influence of wet granules on product quality.

[0092] S10: Packaging and storage

[0093] The finished product is packaged by an automatic packaging line, using moisture-proof and light-proof aluminum foil bags or bottles to ensure product hygiene and safety. During packaging, strict GMP requirements should be followed to avoid cross-contamination and other safety hazards.

[0094] Example Four: Diabetes based on plant extracts, including the following raw materials by weight:

[0095] Bitter gourd extract: 28%, medlar extract: 18%, green tea extract: 14%, polygonatum extract: 9%, ganoderma extract: 10%, salvia extract: 7%, astragalus extract: 6%, black medlar extract: 4%, garlic extract: 4%;

[0096] The preparation method of the above-mentioned plant extract-based diabetic complication nutritional intervention agent specifically comprises the following steps:

[0097] S1: raw material preparation

[0098] According to the formula, bitter gourd extract, medlar extract, green tea extract, polygonatum extract, ganoderma extract, salvia extract, astragalus extract, black medlar extract, and garlic extract are weighed according to the mass fraction, respectively;

[0099] S2: plant material selection and treatment

[0100] High-quality plant raw materials meeting the GMP standard are selected, all plant raw materials are cleaned, impurities are removed, and then placed in a ventilated place at room temperature for 12 h natural air drying;

[0101] S3: crushing and drying treatment

[0102] The treated plant material is crushed into a powder with a particle size of 0.5 mm, and low-temperature vacuum drying technology is used to dry the crushed plant material, ensuring that the water is removed without damaging the effective components of the plant. The dried plant material should maintain the stability of the active ingredients;

[0103] S4: soaking and extraction

[0104] The treated plant material is soaked with 90% ethanol solution at a ratio of 1:10, and the soaking time is 24 hours, and the plant effective components are fully dissolved by stirring every 6 hours. In order to improve the extraction efficiency, ultrasonic extraction method is adopted, the ultrasonic power is set to 500 W, the frequency is 40 kHz, the temperature is controlled at 45℃, and the extraction time is 1 hour;

[0105] S5: concentration and drying

[0106] The extract is concentrated by a rotary evaporator to remove the ethanol solvent and obtain a concentrated liquid. The concentrated liquid is further dried by vacuum drying method to obtain a dry powder of plant extract. The dry powder should retain the main active ingredients in each plant, such as momorcharin in bitter gourd extract, polysaccharide in medlar, tea polyphenol in green tea, saponin in polygonatum, polysaccharide in ganoderma, tanshinone in salvia extract, astragalus polysaccharide in astragalus extract, anthocyanin in black medlar extract, and allicin in garlic extract;

[0107] S6: active ingredient identification and standardization

[0108] The main active ingredients in the extracts are qualitatively and quantitatively analyzed by high performance liquid chromatography to ensure that the content of active ingredients in each extract meets the standard requirements, for example, the content of momorcharin, polysaccharide of medlar, tea polyphenol, polygonatum saponin, ganoderma lucidum polysaccharide, tanshinone, astragalus polysaccharide, black medlar anthocyanin, and allicin is determined to ensure that each component meets the efficacy standard required for treating diabetes;

[0109] S7: Biological activity detection

[0110] The biological activity of each plant extract is verified by cell culture method and animal experiment, for example, the blood glucose change of a diabetes model animal is tested by using a blood glucose meter, and the antioxidant effect is detected by using superoxide dismutase activity determination method to verify the hypoglycemic and antioxidant effects of each extract;

[0111] S8: Formula design and preparation

[0112] The plant extracts are mixed according to the proportion in S1, and an appropriate amount of gelatin is added to ensure that each component is uniformly distributed and the inactivation of active ingredients is avoided;

[0113] S9: Wet granulation and drying

[0114] When wet granulation is performed, an appropriate amount of wetting agent is added to wet the mixture to a suitable degree for granulation, and the wet granules are dried at 55°C for 1 hour to ensure uniform drying of the granules and avoid the influence of wet granules on product quality due to incomplete drying;

[0115] S10: Packaging and storage

[0116] The finished product is packaged by an automatic packaging line, and aluminum foil bags or bottles are used for packaging to ensure the hygiene and safety of the product. During the packaging process, it is necessary to strictly follow the GMP requirements to avoid cross contamination and other safety hazards.

[0117] The above shows and describes the basic principles and main features of the present application and the advantages of the present application. Those skilled in the art should understand that the present application is not limited to the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the claimed present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. Diabetes based on plant extracts, characterized in that, The ingredients include the following components by weight: bitter melon extract: 25%-30%, wolfberry extract: 15%-25%, green tea extract: 10%-15%, polygonatum extract: 9%-12%, ganoderma extract: 5%-10%, salvia miltiorrhiza extract: 5%-7%, astragalus extract: 5%-7%, black wolfberry extract: 4%-5%, and garlic extract: 5%-8%.

2. A method for preparing a plant extract-based nutritional intervention agent for diabetic complications as described in claim 1, characterized in that: Specifically, the following steps are included: S1: Raw material preparation: Weigh out the following extracts according to the formula: bitter melon extract, wolfberry extract, green tea extract, polygonatum extract, ganoderma extract, salvia miltiorrhiza extract, astragalus extract, black wolfberry extract, and garlic extract. S2: Plant material selection and processing. Select high-quality plant materials that meet GMP standards. All plant materials must be cleaned and impurities removed. After being placed in a ventilated place, they should be left to air dry naturally at room temperature for 12 hours. S3: Crushing and drying process. The processed plant material is crushed and dried using low-temperature vacuum drying technology to ensure that moisture is removed without damaging the plant's effective components. The dried plant material should maintain the stability of the active ingredients. S4: Soaking and extraction. The treated plant material is soaked in a 60%-90% ethanol solution at a ratio of 1:10 for 24 hours, with stirring every 6 hours to ensure full dissolution of the plant's active ingredients. To improve extraction efficiency, ultrasonic extraction is used. S5: Concentration and Drying. The extract is concentrated using a rotary evaporator to remove the ethanol solvent, resulting in a concentrated liquid. The concentrated liquid is then further dried using a vacuum drying method to remove excess water, yielding a dry powder of the plant extract. The dry powder should retain the main active ingredients of each plant, such as momordicin in bitter melon extract, polysaccharides in wolfberry, tea polyphenols in green tea, saponins in polygonatum, polysaccharides in ganoderma, tanshinone in salvia miltiorrhiza extract, astragalus polysaccharides in astragalus extract, anthocyanins in black wolfberry extract, and allicin in garlic extract. S6: Identification and standardization of active ingredients. Qualitative and quantitative analysis of the main active ingredients in the extracts is performed using high performance liquid chromatography to ensure that the content of active ingredients in each extract meets the standard requirements. For example, the content of ingredients such as momordicin, wolfberry polysaccharide, tea polyphenols, polygonatum saponins, ganoderma lucidum polysaccharide, tanshinone, astragalus polysaccharide, black wolfberry anthocyanin, and allicin is determined to ensure that each ingredient meets the efficacy standards required for the treatment of diabetes. S7: Bioactivity assay. The bioactivity of each plant extract is verified by cell culture and animal experiments. For example, blood glucose meters are used to test blood glucose changes in diabetic model animals, and superoxide dismutase activity is used to detect antioxidant effects in order to verify the hypoglycemic and antioxidant effects of each extract. S8: Formula design and formulation. Mix the plant extracts according to the proportions in S1, add an appropriate amount of gelatin, ensure that each ingredient is evenly distributed, and avoid the deactivation of active ingredients. S9: Wet granulation and drying. During wet granulation, add an appropriate amount of wetting agent to wet the mixture to a degree suitable for granulation, ensuring that the granules are dried evenly and avoiding the impact of incomplete drying on product quality. S10: Packaging and storage. Finished products are packaged through automated packaging lines using moisture-proof and light-proof aluminum foil bags or bottles to ensure product hygiene and safety. During the packaging process, strict adherence to GMP requirements is required to avoid cross-contamination and other safety hazards.

3. The method for preparing a nutritional intervention agent for diabetic complications based on plant extracts according to claim 2, characterized in that: In S3, the powder is pulverized to a particle size of 0.5 mm.

4. The method for preparing a nutritional intervention agent for diabetic complications based on plant extracts according to claim 2, characterized in that: In S4, the ultrasonic power is set to 500W, the frequency is 40kHz, the temperature is controlled at 30℃-45℃, and the extraction time is 1 hour.

5. The method for preparing a nutritional intervention agent for diabetic complications based on plant extracts according to claim 2, characterized in that: In step S9, the wet granules are dried at 40°C-55°C for 1 hour.