A method and system for closed-loop control of neuromorphic and organoid electrical stimulation

By employing a closed-loop control method for neuromorphic organoid electrical stimulation, stimulation parameters can be monitored and adjusted in real time, solving the problem of fixed stimulation parameters in existing technologies. This achieves efficient neural activity regulation and experimental reliability, expanding the application potential of neuromorphic organoids in brain-computer interface research and neurological disease modeling.

CN121065412BActive Publication Date: 2026-05-26WENZHOU INST UNIV OF CHINESE ACAD OF SCI +1
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Patent Information

Application Number
CN202511614275.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-11-06
Publication Date
2026-05-26
Estimated Expiration
2045-11-06

AI Technical Summary

Technical Problem

Existing brain-like organoid electrical stimulation technology uses an open-loop mode with fixed stimulation parameters, making it difficult to adjust according to real-time neural responses and lacking a feedback mechanism. This limits research methods and prevents the flexible adjustment and optimization of neural activity.

Method used

A closed-loop control method based on brain-like and organoid electrical stimulation is adopted, integrating an electrical signal monitoring module and an intelligent feedback control algorithm to monitor neural responses in real time and adaptively adjust stimulation parameters, thereby constructing a closed-loop control system of stimulation-response-regulation.

Benefits of technology

It achieves precise and adjustable local stimulation and synchronous monitoring, constructs a complete feedback mechanism, provides flexible stimulation strategies, improves the reproducibility and reliability of experiments, and enhances the flexibility and precision of neuroscience research.

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Abstract

This invention discloses a closed-loop control method and system for electrical stimulation of brain-like organoids, relating to the field of bioelectrical signal modulation technology. The method includes: configuring sensing and stimulating electrode regions and acquiring baseline correction parameters; defining a set of stimulation units including fixed and feedback modes; executing a closed-loop control process, acquiring sensing electrode signals in real time, calculating the electrical signal intensity of each region after baseline correction; and dynamically allocating stimulation units from a subset of feedback modes to each stimulation electrode region and applying electrical stimulation based on the corrected electrical signal intensity. The system includes modules for electrode region configuration, baseline correction, stimulation unit definition, parameter import, and closed-loop control. This invention achieves closed-loop control of stimulus-response-regulation, enabling dynamic adjustment of stimulation parameters based on real-time neural activity in brain-like organoids, significantly improving the specificity, adaptability, and experimental reliability of electrical stimulation.
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Citation Information

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