Preparation method of roselle hangover alleviating lozenge

Abstract

The invention discloses a preparation method of roselle hangover-alleviating buccal tablets, and particularly relates to the field of preparation methods. The lozenge is prepared from the following raw materials in parts by weight: 5-15 parts of a roselle extract, 5-15 parts of a radix puerariae powder extract, 1-5 parts of hydroxypropyl methylcellulose, 5-10 parts of xylitol, 0.5-1.5 parts of magnesium stearate and 1000ml of water. The preparation method of the lozenge comprises the following steps: S1, weighing the raw materials in parts by weight; s2, uniformly mixing the roselle extract, the radix puerariae powder extract, xylitol and hydroxypropyl methylcellulose to obtain a mixed material; and S3, adding magnesium stearate into the mixed material, uniformly mixing, and tabletting to obtain the roselle alcohol effect dispelling lozenge. The problem that an existing anti-alcoholism product cannot give consideration to both high efficiency and safety is solved, and the economic added value of the roselle is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of preparation methods, in particular to a preparation method of a hibiscus sabdariffa L. loquat alcohol-containing tablet. BACKGROUND

[0002] Drinking is an important form of social activity in modern society, widely existing in business negotiations, holiday parties and daily leisure scenes. However, the health problems caused by excessive drinking are increasingly prominent. In the short term, it can manifest as acute hangover symptoms such as headache, nausea, vomiting, and inattention, and in the long term, it can lead to chronic diseases such as liver steatosis, cirrhosis, gastrointestinal mucosa damage, and nervous system function degradation. According to the World Health Organization, more than 3 million people die from alcohol-related diseases every year, of which liver diseases account for more than 40%, highlighting the severity of alcohol harm.

[0003] At present, there are various types of alcohol products on the market, including chemical synthetic drugs, natural plant extracts and functional foods, but they all have technical defects. Chemical alcohol products (such as products containing naloxone) can quickly relieve symptoms, but may cause drug dependence and side effects such as dizziness and palpitations; natural ingredient products (such as pueraria powder and curcumin capsules) have low bioavailability and slow onset, making it difficult to meet the immediate alcohol relief needs. In addition, the existing alcohol products are mainly in the form of oral liquid, capsule or powder, which have problems such as bitter taste, need to be taken with water, and inconvenience to carry. Especially in social situations, consumers urgently need alcohol products that do not require water and can be directly taken, but the market has not provided an effective solution.

[0004] Hibiscus sabdariffa L. is a traditional medicinal and edible plant. Its calyx is rich in polyphenols (such as cyanidin-3-glucoside), organic acids (citric acid, malic acid) and vitamin C, and has significant antioxidant and liver protection effects. Modern pharmacological studies have shown that hibiscus sabdariffa L. extract can accelerate ethanol metabolism to acetic acid by up-regulating the activities of liver alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), and shorten the retention time of alcohol in the body; at the same time, its polyphenol components can scavenge free radicals generated during alcohol metabolism, reduce the damage of oxidative stress to liver cells and gastric mucosa, and thus relieve hangover symptoms. However, in the existing technology, hibiscus sabdariffa L. is mostly used in the form of dried calyx direct infusion or simple water extract, which has problems such as low dissolution rate of active ingredients and poor stability, and lacks dosage form design for alcohol relief scenarios, resulting in that its alcohol relief efficiency has not been fully explored.

[0005] Therefore, there is an urgent need to develop an efficient, convenient and good-tasting alcohol relief product. SUMMARY

[0006] The present application intends to provide a preparation method of a Lobelia chinensis anti-alcoholic lozenge, and solve the problem that the existing anti-alcoholic products cannot balance high efficiency and safety.

[0007] To achieve the above-mentioned purpose, the technical scheme of the present application is as follows: a preparation method of a Lobelia chinensis anti-alcoholic lozenge, the lozenge is made of the following raw materials by weight: Lobelia chinensis extract 5-15 parts, Pueraria lobata extract 5-15 parts, hydroxypropyl methyl cellulose 1-5 parts, xylitol 5-10 parts, magnesium stearate 0.5-1.5 parts, and water 1000ml; the preparation method of the lozenge comprises the following steps:

[0008] S1, each raw material is weighed according to the weight;

[0009] S2, the Lobelia chinensis extract, the Pueraria lobata extract, the xylitol, and the hydroxypropyl methyl cellulose are uniformly mixed to obtain a mixture;

[0010] S3, the magnesium stearate is added to the mixture, and the mixture is uniformly mixed and then pressed into a tablet to obtain the Lobelia chinensis anti-alcoholic lozenge.

[0011] Further, the content of cyanidin-3-glucoside in the Lobelia chinensis extract is ≥5% (w / w), the content of puerarin in the Pueraria lobata extract is ≥8% (w / w), and the total content of the active ingredients of the two is 10%-30% of the weight of the lozenge.

[0012] Further, the particle size of the xylitol is 80-120 mesh, and the ratio of the addition amount of the xylitol to the total weight of the Lobelia chinensis extract and the Pueraria lobata extract is 1:1-1:2. The balance of the sweet and sour taste and the anti-alcoholic activity of the lozenge is balanced.

[0013] Further, the viscosity of the hydroxypropyl methyl cellulose is 50-150 mPa·s, and the addition amount of the hydroxypropyl methyl cellulose accounts for 5%-15% of the total weight of the lozenge for adjusting the hardness and disintegration performance of the lozenge.

[0014] Further, the particle size of the magnesium stearate is 100-200 mesh, and the addition amount of the magnesium stearate accounts for 0.5%-2% of the total weight of the mixture. The phenomenon of sticking or cracking in the tabletting process is prevented.

[0015] Further, the tablet specifications of the lozenge are as follows: the diameter is 8-12mm, the thickness is 3-5mm, the single tablet weight is 0.8-1.5g, the hardness is controlled at 40-80N, and the friability is ≤1%.

[0016] Further, the disintegration time of the lozenge in artificial saliva at 37℃ is 30 seconds to 3 minutes, and the pH value of the solution after disintegration is 5-6.5, and there is no visible particle residue.

[0017] Further, the storage conditions of the lozenge are: sealed from light, relative humidity ≤ 60%, and the effective period at room temperature is 12 months, and the attenuation rate of the active ingredient content during the period is ≤ 10%.

[0018] Further, in the preparation process of the lozenge, the mixing temperature of the mixture is 25-30℃, the mixing time is 15-20 minutes, and the mixing speed is 60-80r / min.

[0019] Further, the taste optimization standard of the lozenge is: the sweet-sour ratio of xylitol: extract sourness is 1:0.8-0.9:1.1, and the taste perception is clear within 30 seconds after entry, without obvious grit or sticky teeth phenomenon.

[0020] Compared with the prior art, the beneficial effects of the present scheme are:

[0021] 1. The loquat flower extract (cyanidin-3-glucoside content ≥ 5% (w / w)) is used as the core active ingredient, and the pueraria root extract (puerarin content ≥ 8% (w / w)) is used as the traditional alcoholism-preventing and liver-protecting medicinal material. Modern pharmacological research has proved that the loquat flower extract has a unique mechanism of action, which can up-regulate the activities of liver alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), thereby accelerating the process of ethanol metabolism into acetic acid, effectively shortening the residence time of alcohol in the body. The polyphenol components contained therein can also scavenge free radicals generated during alcohol metabolism, reducing the damage to liver cells and gastric mucosa caused by oxidative stress.

[0022] 2. In the present application, the pueraria root, as a traditional alcoholism-preventing and liver-protecting medicinal material, cooperates with the loquat flower to form a strong complementary effect. The total content of the active ingredients of the two is 10%-30% of the weight of the lozenge, which greatly improves the alcoholism-preventing and liver-protecting function of the lozenge. The use of the lozenge can effectively relieve the discomfort symptoms such as headache, nausea, vomiting and other symptoms caused by hangover, and reduce the risk of chronic diseases such as liver steatosis, liver cirrhosis, gastrointestinal mucosa damage and nervous system function degradation caused by long-term drinking.

[0023] 3. Compared with the existing natural ingredient products on the market (such as pueraria powder and curcumin capsules), the loquat flower alcoholism-preventing lozenge has unique advantages. It does not need to go through a complex digestion and absorption process, and can directly enter the blood circulation through oral administration, quickly exerting the alcoholism-preventing and liver-protecting effect. Moreover, xylitol replaces sucrose to adjust the taste, and its cooling property can also relieve the post-drinking dry heat. The overall effect is mild and non-irritating, avoiding the side effects such as drug dependence, dizziness and palpitations that may be caused by chemical alcoholism-preventing agents (such as those containing naloxone).

[0024] 4. This invention involves no solvent addition throughout the entire process and requires no recovery equipment such as rotary evaporation. Production can be completed through a very simple process of dry powder mixing, tableting, and packaging, which greatly reduces energy consumption and costs. It requires little equipment and is suitable for small and medium-sized enterprises and rapid industrial production. Detailed Implementation

[0025] The present invention will be further described in detail below through specific embodiments:

[0026] Example 1

[0027] A method for preparing a hibiscus-based hangover relief lozenge, comprising the following raw materials in parts by weight: 5 parts hibiscus extract (containing 5% cyanidin-3-glucoside), 5 parts kudzu root extract (containing 8% puerarin), 1 part hydroxypropyl methylcellulose (viscosity 50 mPa·s (2% aqueous solution, 20℃)), 5 parts xylitol (80 mesh particle size), 0.5 parts magnesium stearate (100 mesh particle size), and 1000 ml water. The preparation method includes the following steps:

[0028] S1. Weighing: Weigh each raw material according to the above proportions.

[0029] S2. Mixing: Place the roselle extract, kudzu root extract, xylitol, and hydroxypropyl methylcellulose in a mixer, control the temperature at 25℃ and the speed at 80r / min, and mix for 15 minutes to obtain a uniform mixture.

[0030] S3. Tableting: Add magnesium stearate, continue mixing for 5 minutes, then use a 12mm die to compress the tablets, controlling the tablet diameter to be 8mm, the thickness to be 3mm, the weight of a single tablet to be 0.8g, the hardness to be 45N, and the friability to be 0.8%.

[0031] S4. Packaging: Store in a sealed container away from light, with a relative humidity of ≤60%. Shelf life is 12 months at room temperature.

[0032] Effect evaluation:

[0033] Disintegration performance: The disintegration time in artificial saliva at 37℃ was 2 minutes and 30 seconds, the pH value of the solution after disintegration was 5.2, and there was no particle residue.

[0034] Taste: The ratio of sweet to sour is 1:0.9. The taste is clear within 30 seconds of tasting, with no obvious gritty feeling.

[0035] Hangover relief effect: In vitro experiments showed that the tablets could increase the activity of alcohol dehydrogenase (ADH) by 22%, aldehyde dehydrogenase (ALDH) by 18%, and the alcohol metabolism rate was increased by 35% compared with the control group.

[0036] Stability: The active ingredient decay rate was 8.5% after 12 months, which meets the standard.

[0037] This product is suitable for cost-sensitive consumers who need basic hangover relief, or it can be promoted as an entry-level product.

[0038] Example 2

[0039] A method for preparing a hibiscus-based hangover relief lozenge, comprising the following raw materials in parts by weight: 10 parts hibiscus extract (containing 7.5% cyanidin-3-glucoside), 10 parts kudzu root extract (containing 10% puerarin), 3 parts hydroxypropyl methylcellulose (viscosity 100 mPa·s (2% aqueous solution, 20℃)), 8 parts xylitol (particle size 100 mesh), 1 part magnesium stearate (particle size 150 mesh), and 1000 ml water. The preparation method includes the following steps:

[0040] S1. Weighing: Weigh each raw material according to the above proportions.

[0041] S2. Mixing: Place the extract, xylitol, and hydroxypropyl methylcellulose in a mixer, control the temperature at 25℃ and the speed at 70r / min, and mix for 18 minutes to ensure there are no lumps.

[0042] S3. Tableting: Add magnesium stearate, mix for 8 minutes, and then compress into tablets using a 10mm die. Control the tablet diameter to be 10mm, the thickness to be 4mm, the weight of a single tablet to be 1.1g, the hardness to be 60N, and the friability to be 0.5%.

[0043] S4. Packaging: Same as in Example 1.

[0044] Effect evaluation:

[0045] Disintegration performance: Disintegration time 1 minute 15 seconds, pH value 5.8, no particle residue.

[0046] Taste: The ratio of sweet to sour is 1:1.0. The taste is clear within 25 seconds of entering the mouth and there is no stickiness.

[0047] Hangover relief effects: ADH activity increased by 28%, ALDH activity increased by 25%, and alcohol metabolism rate increased by 42%.

[0048] Stability: The active ingredient attenuation rate was 6.2% after 12 months, which is better than that of Example 1.

[0049] This product offers the best value for money, balancing hangover relief efficiency with cost control, making it suitable for both the mass market and industrial production.

[0050] Example 3

[0051] A method for preparing a hibiscus-based hangover relief lozenge, comprising the following raw materials in parts by weight: 15 parts hibiscus extract (containing 10% cyanidin-3-glucoside), 15 parts kudzu root extract (containing 12% puerarin), 5 parts hydroxypropyl methylcellulose (viscosity 150 mPa·s (2% aqueous solution, 20℃)), 10 parts xylitol (particle size 120 mesh), 1.5 parts magnesium stearate (particle size 200 mesh), and 1000 ml water. The preparation method includes the following steps:

[0052] S1. Weighing: Weigh each raw material according to the above proportions.

[0053] S2. Mixing: Place the extract, xylitol, and hydroxypropyl methylcellulose in a mixer, control the temperature at 30℃ and the speed at 60r / min, and mix for 20 minutes to ensure uniform dispersion.

[0054] S3. Tableting: Add magnesium stearate, mix for 10 minutes, and then compress into tablets using an 8mm die. Control the tablet diameter to be 12mm, the thickness to be 5mm, the weight of a single tablet to be 1.5g, the hardness to be 75N, and the friability to be 0.3%.

[0055] S4. Packaging: Same as in Example 1.

[0056] Effect evaluation:

[0057] Disintegration performance: Disintegration time 45 seconds, pH 6.2, no particle residue.

[0058] Taste: The ratio of sweet to sour is 1:1.1. The taste is clear within 20 seconds of tasting, with a slight cooling sensation.

[0059] Hangover relief effects: ADH activity increases by 35%, ALDH activity increases by 30%, and alcohol metabolism rate increases by 50%.

[0060] Stability: The active ingredient decay rate was 4.8% after 12 months, which was significantly better than the previous two cases.

[0061] This product is suitable for consumers who have extremely high requirements for hangover relief efficiency, or it may be positioned as a high-end product, but the cost is relatively high.

[0062] The comparison of the lozenge products in Examples 1-3 is shown in Table 1 below.

[0063] Table 1

[0064]

[0065] As can be seen from Table 1 above:

[0066] Alcohol-relieving efficiency: The dosage of the extract is positively correlated with the viscosity of hydroxypropyl methylcellulose. Example 3 showed the best effect, but the cost was higher; Example 1 had the lowest cost and was suitable for basic needs.

[0067] Process balance: Example 2 is the most cost-effective solution, taking into account the hangover relief efficiency, taste and stability, and is suitable for industrial production.

[0068] Market positioning: Different formulas can be selected according to the target audience. For example, Example 3 is recommended for the high-end market and Example 2 is recommended for the mass market.

[0069] The above are merely embodiments of the present invention, and common knowledge such as specific structures and / or characteristics in the solutions are not described in detail here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the structure of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A method for preparing hibiscus flower hangover relief lozenges, characterized in that, The lozenge is made from the following raw materials in parts by weight: 5-15 parts of roselle extract, 5-15 parts of kudzu root extract, 1-5 parts of hydroxypropyl methylcellulose, 5-10 parts of xylitol, 0.5-1.5 parts of magnesium stearate, and 1000 ml of water; the preparation method of the lozenge includes the following steps: S1. Weigh each raw material according to the stated weight proportions; S2. Mix the roselle extract, kudzu root extract, xylitol, and hydroxypropyl methylcellulose evenly to obtain a mixture. S3. Add magnesium stearate to the mixture, mix well, and then compress into tablets to obtain hibiscus hangover relief tablets.

2. The method for preparing a hibiscus flower hangover relief lozenge according to claim 1, characterized in that: The hibiscus extract contains ≥5% (w / w) cyanidin-3-glucoside, and the kudzu root extract contains ≥8% (w / w) puerarin, and the total content of the two active ingredients accounts for 10%-30% of the weight of the lozenge.

3. The method for preparing a hibiscus flower hangover relief lozenge according to claim 1, characterized in that: The xylitol has a particle size of 80-120 mesh, and its addition amount is in the ratio of the total weight of roselle extract and kudzu root extract to 1:1-1:

2.

4. The method for preparing a hibiscus flower hangover relief lozenge according to claim 1, characterized in that: The viscosity of the hydroxypropyl methylcellulose is 50-150 mPa·s, and its addition amount accounts for 5%-15% of the total weight of the lozenges.

5. The method for preparing a hibiscus flower hangover relief lozenge according to claim 1, characterized in that: The magnesium stearate has a particle size of 100-200 mesh, and its addition amount accounts for 0.5%-2% of the total weight of the mixture.

6. The method for preparing a hibiscus hangover relief lozenge according to claim 1, characterized in that: The tablet specifications of the lozenges are: diameter 8-12mm, thickness 3-5mm, single tablet weight 0.8-1.5g, hardness controlled at 40-80N, and friability ≤1%.

7. The method for preparing a hibiscus hangover relief lozenge according to claim 1, characterized in that: The tablet disintegrates in artificial saliva at 37°C within 30 seconds to 3 minutes, and the pH of the solution after disintegration is 5-6.5 with no visible particle residue.

8. The method for preparing a hibiscus hangover relief lozenge according to claim 7, characterized in that: The storage conditions for the lozenges are as follows: sealed and protected from light, relative humidity ≤60%, and shelf life of 12 months at room temperature, during which the content of active ingredients decreases by ≤10%.

9. The method for preparing a hibiscus hangover relief lozenge according to claim 7, characterized in that: During the preparation of the lozenges, the mixing temperature of the mixture is 25-30℃, the mixing time is 15-20 minutes, and the mixing speed is 60-80 r / min.

10. The method for preparing a hibiscus flower hangover relief lozenge according to claim 7, characterized in that: The taste optimization standard for the lozenges is as follows: the ratio of the acidity and sweetness of xylitol to extract is 1:0.8-0.9:1.1, and the taste perception is clear within 30 seconds after entering the mouth, without obvious gritty feeling or stickiness.

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