Granulation-promoting and skin-soothing cream as well as preparation method and application thereof

Abstract

The invention discloses tissue regeneration promoting and skin care cream as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine external preparations. According to the tissue regeneration promoting and skin soothing cream, dragon's blood and frankincense are used as monarch drugs, dragon bone, myrrh and lithospermum are used as ministerial drugs, cuttlebone, borneol and the like are used as adjuvant drugs, honeysuckle stem and selfheal are used as conductant drugs, compatibility is performed according to specific dosage, the principle of monarch, minister, assistant and conductant is followed, and the formula is scientific and reasonable. The preparation method adopts the processes of sesame oil soaking, deep-frying extraction and beeswax cream forming, can effectively treat 20 skin and trauma diseases such as dermatitis, wound surfaces and skin lesions, is low in adverse reaction incidence rate and high in safety, solves the problems of large side effects, single indications and weak repair ability of the existing medicine, and has a wide application prospect. Good clinical popularization values and application prospects are realized.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, and in particular to a skin-regenerating and skin-soothing ointment, its preparation method, and its application. Background Technology

[0002] Skin and trauma conditions are common clinical conditions, encompassing various types such as dermatitis, wound infection, and skin degeneration. They not only affect the patient's appearance but are also often accompanied by symptoms such as pain, itching, and infection, severely reducing the patient's quality of life. If some conditions (such as diabetic foot and bedsores) are not treated in time, they may also lead to serious complications such as amputation and systemic infection.

[0003] Currently, there are many drugs and methods for treating the aforementioned skin and trauma conditions, but they have many shortcomings and cannot meet clinical needs, as detailed below:

[0004] Existing topical medications have limitations in efficacy: For inflammatory conditions such as insect bite dermatitis and steroid dermatitis, while existing steroid ointments can provide short-term relief from itching and redness, long-term use can easily lead to side effects such as skin atrophy, telangiectasia, and drug resistance. For wound conditions such as bedsores and diabetic foot, existing ointments can only provide basic antibacterial or moisturizing effects and cannot simultaneously achieve multiple effects such as promoting wound healing, anti-inflammation, and antibacterial properties, resulting in long treatment cycles and significant patient suffering.

[0005] Existing drugs have insufficient safety: Some drugs for treating skin lesions (such as drugs for treating vulvar leukoplakia) contain irritating ingredients, which can easily cause local stinging and burning sensations after use, and long-term use may damage normal skin tissue; in addition, some drugs pose a risk of skin allergies, which limits their widespread use in clinical practice.

[0006] Existing preparation processes are complex and their effects are unstable: The preparation processes of some topical ointments involve complex steps such as multiple extractions and purifications, which not only increase production costs but may also lead to the loss of effective ingredients. At the same time, some processes have strict requirements for the control of parameters such as temperature and time. If the parameters are not properly controlled, it can easily lead to poor ointment stability and uneven content of effective ingredients, thus affecting the efficacy.

[0007] Therefore, this invention proposes a topical ointment that has comprehensive therapeutic effects, high safety, and a simple and stable preparation process. Summary of the Invention

[0008] In view of the above-mentioned shortcomings in the prior art and based on the defects of the prior art, the present invention aims to provide a skin-regenerating and soothing ointment with a scientific formula, advanced preparation process, wide range of indications and definite curative effect, so as to solve the problems of "large side effects, single indications and weak repair ability" in the treatment of skin and trauma diseases.

[0009] A skin-regenerating and soothing ointment is prepared from the following medicinal materials in parts by weight: 30-50 parts of dragon's blood, 30-50 parts of frankincense, 30-50 parts of dragon bone, 30-50 parts of myrrh, 150-300 parts of gromwell root, 80-150 parts of cuttlebone, 80-150 parts of borneol, 10-30 parts of raw rhubarb, 10-30 parts of angelica root, 10-30 parts of raw rehmannia root, 10-30 parts of angelica dahurica, 10-30 parts of notoginseng powder, 20-40 parts of honeysuckle vine, and 20-40 parts of prunella vulgaris.

[0010] It also includes essential oils and beeswax as a base.

[0011] Further, it is prepared from the following medicinal materials in parts by weight: 40 parts of dragon's blood, 40 parts of frankincense, 40 parts of dragon bone, 40 parts of myrrh, 200 parts of gromwell root, 100 parts of cuttlebone, 100 parts of borneol, 18 parts of raw rhubarb, 18 parts of angelica, 18 parts of raw rehmannia root, 18 parts of angelica dahurica, 18 parts of notoginseng powder, 30 parts of honeysuckle vine, and 30 parts of prunella vulgaris.

[0012] The amount of sesame oil used is 10 times the total mass of the medicinal materials, and the amount of beeswax used is 5% of the mass of the filtrate after extraction of the medicinal materials and sesame oil.

[0013] A method for preparing a skin-regenerating and soothing cream, characterized by comprising the following steps:

[0014] S1: Pre-treatment of medicinal materials: crush the following ingredients into coarse powder: blood dragon, frankincense, dragon bone, myrrh, gromwell root, cuttlebone, raw rhubarb, angelica, rehmannia root, angelica dahurica, honeysuckle vine, and prunella vulgaris into 80-100 mesh coarse powder; pass the notoginseng powder through a 120 mesh sieve for later use; and grind borneol into fine powder for later use.

[0015] S2: Sesame oil soaking: Add the coarse powder of the 12 medicinal materials prepared in step S1 to 10 times its weight of sesame oil, seal and soak for 7 days, stirring once a day during the period;

[0016] S3: Deep-frying extraction: Place the soaked herbs and sesame oil in a stainless steel pot, heat over low heat to 120-130℃, and simmer for 2-3 hours until the surface of the herbs turns yellowish-brown and emits a charred aroma. Then stop heating.

[0017] S4: Filtration and slag removal: When the temperature of the liquid medicine drops to 80-90℃, filter it while it is still hot using a 300-mesh filter screen and collect the filtrate;

[0018] S5: Forming and Packaging: Cool the filtrate to 60-70℃, add 5% beeswax by weight of the filtrate, stir until the beeswax is completely melted, then add the prepared Panax notoginseng powder and borneol powder, stir quickly and evenly, cool to 40-50℃, then package and seal, and cool to room temperature to obtain the final product.

[0019] The application of a skin-regenerating and skin-soothing ointment in the preparation of drugs for treating skin and traumatic conditions, including insect bite dermatitis, hormone-dependent dermatitis, photodermatitis, allergic dermatitis, contact dermatitis, seborrheic dermatitis, and neurodermatitis.

[0020] The application of the aforementioned skin-regenerating ointment in the preparation of drugs for treating wound-related conditions, including pressure ulcers (stages I-IV), diabetic foot ulcers, superficial to deep II-degree burns, superficial to deep II-degree scalds, abrasions, lacerations, post-surgical suture wounds, and infected wounds.

[0021] The application of a skin-regenerating and skin-soothing ointment in the preparation of drugs for treating skin lesions, including vulvar leukoplakia, onychomycosis, vitiligo, skin ulcers, skin lesions left by postherpetic neuralgia, and eczematous dermatitis.

[0022] Furthermore, the method of using the skin-regenerating and soothing ointment is as follows: after cleaning and drying the affected skin, apply the ointment evenly to the affected area with a thickness of 0.5-1mm, and apply 2-3 times a day; for mild symptoms, use the medication for 5-7 days, for moderate symptoms for 10-14 days, and for severe symptoms for 20-30 days.

[0023] The beneficial effects of this invention are as follows:

[0024] The skin-regenerating and soothing cream of this invention adopts the principle of monarch-minister-assistant-guide compatibility, and the formula is analyzed as follows:

[0025] The principal ingredients (dragon's blood and frankincense): Dragon's blood invigorates blood circulation, relieves pain, removes blood stasis, stops bleeding, promotes tissue regeneration, and heals sores; frankincense invigorates blood circulation, promotes qi circulation, reduces swelling, and promotes tissue regeneration. Together, they serve as the principal ingredients, exerting the core effects of tissue regeneration, repair, and analgesia, targeting wound healing and pain symptoms.

[0026] Assistant herbs (dragon bone, myrrh, and gromwell): Dragon bone has astringent and hemostatic properties, promotes tissue regeneration and wound healing, enhancing the wound-healing effect of the principal herbs; myrrh promotes blood circulation, relieves pain, reduces swelling and promotes tissue regeneration, assisting frankincense in enhancing the efficacy; gromwell cools the blood, promotes blood circulation, detoxifies and promotes rash eruption, targeting heat-related conditions such as dermatitis and skin inflammation. Together, these three herbs serve as assistant herbs, taking into account astringency, anti-inflammation, and repair.

[0027] The adjuvant herbs (cuttlebone, borneol, raw rhubarb, angelica, rehmannia, angelica dahurica, and notoginseng powder) are as follows: Cuttlebone has astringent and hemostatic properties, and is used to stop vaginal discharge and vulvar leukoplakia, as well as for symptoms such as wound bleeding; Borneol clears the mind and refreshes the spirit, clears heat and relieves pain, and enhances the permeability of the ointment, quickly relieving itching and pain; Raw rhubarb clears heat and purges fire, cools the blood and detoxifies, and is used for infected wounds; Angelica dahurica nourishes and invigorates blood, regulates menstruation and relieves pain, promotes blood circulation in the skin, and accelerates tissue regeneration; Rehmannia glutinosa clears heat and cools the blood, nourishes yin and generates fluids, and prevents the ointment from being too warm and damaging the skin; Angelica dahurica relieves exterior syndromes and dispels cold, dispels wind and relieves pain, and is used for symptoms caused by external factors such as photodermatitis; Notoginseng powder disperses blood stasis, stops bleeding, reduces swelling and relieves pain, and enhances the hemostatic and analgesic effects of the ointment. This group of adjuvant herbs not only assists the principal and assistant herbs in enhancing efficacy but also addresses a variety of symptoms, expanding the scope of indications.

[0028] Guiding herbs (honeysuckle vine, prunella vulgaris): Honeysuckle vine clears heat and detoxifies, dispels wind and unblocks the meridians, while prunella vulgaris clears liver heat, disperses nodules and reduces swelling. Together, they serve as guiding herbs to reach the lesion, while also enhancing the heat-clearing and detoxifying effects of the ointment, which is effective for infectious diseases.

[0029] The skin-regenerating and soothing cream of this invention, through its scientific formula and advanced preparation process, has the following advantages:

[0030] 1. Wide range of indications: It can effectively treat 20 kinds of skin and trauma diseases, including dermatitis, wounds, and skin lesions, solving the problem of single indications of existing drugs;

[0031] 2. Definite therapeutic effect: It can significantly shorten the symptom relief time and recovery time, improve the wound healing rate and overall effectiveness, especially for difficult-to-heal wounds (such as diabetic foot ulcers and bedsores);

[0032] 3. High safety: Low incidence of adverse reactions, no obvious irritation or toxic side effects, avoiding problems such as skin atrophy and drug resistance of existing chemical drugs;

[0033] 4. Good stability: Using sesame oil and beeswax as the base, the ointment has high stability, long shelf life, and is easy to promote and use in clinical practice. Attached Figure Description

[0034] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0035] Figure 1 This is a flowchart of the preparation process of the present invention. Detailed Implementation

[0036] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0037] Example 1

[0038] A skin-regenerating and soothing ointment is prepared from the following medicinal materials in parts by weight: 40 parts of dragon's blood, 40 parts of frankincense, 40 parts of dragon bone, 40 parts of myrrh, 200 parts of gromwell root, 100 parts of cuttlebone, 100 parts of borneol, 18 parts of raw rhubarb, 18 parts of angelica root, 18 parts of raw rehmannia root, 18 parts of angelica dahurica, 18 parts of notoginseng powder, 30 parts of honeysuckle vine, and 30 parts of prunella vulgaris.

[0039] The amount of sesame oil used is 10 times the total mass of the medicinal materials, and the amount of beeswax used is 5% of the mass of the filtrate after extraction of the medicinal materials and sesame oil.

[0040] Preparation method of skin-regenerating and soothing cream

[0041] The skin-regenerating and soothing cream of this invention adopts an advanced process of "soaking in sesame oil - deep-frying extraction - beeswax forming into cream", and the specific steps are as follows:

[0042] 1. Pre-treatment of medicinal materials: Bloodskin, frankincense, dragon bone, myrrh, gromwell root, cuttlebone, raw rhubarb, angelica, rehmannia root, angelica dahurica, honeysuckle vine, and prunella vulgaris are pulverized into 100-mesh coarse powder. Panax notoginseng powder is directly passed through 120-mesh fine powder for later use. Borneol is ground into fine powder for later use (avoid high temperature to prevent damage to active ingredients).

[0043] 2. Sesame oil soaking: Take the pre-treated bloodstains, frankincense, dragon bone, myrrh, gromwell root, cuttlebone, raw rhubarb, angelica, rehmannia root, angelica dahurica, honeysuckle vine, and prunella vulgaris coarse powder, add 10 times the amount (by weight) of sesame oil (white sesame oil, acid value ≤1.0mgKOH / g), seal and soak for 7 days, stirring once a day during this period to ensure that the medicinal materials are fully soaked.

[0044] 3. Deep-frying extraction: Pour the soaked herbs and sesame oil into a stainless steel pot, heat over low heat to 120-130℃, and simmer for 2-3 hours until the surface of the herbs turns yellowish-brown and emits a charred aroma (using thin-layer chromatography to ensure that the extraction rate of effective components is ≥90%), then stop heating.

[0045] 4. Filtration and slag removal: When the temperature of the medicinal liquid drops to 80-90℃, filter it while it is still hot using a 300-mesh filter to remove the medicinal residue and collect the filtrate (i.e., the ointment base).

[0046] 5. Preparation and Packaging: Cool the filtrate to 60-70℃, add 5% (by mass, relative to the filtrate) of beeswax (preferably yellow beeswax, acid value ≤18mg KOH / g), stir until the beeswax is completely melted, then add the prepared Panax notoginseng powder and borneol powder, stir quickly and evenly, continue to cool to 40-50℃, pour into a sterile ointment jar, seal and cool to room temperature to obtain the skin-regenerating and soothing ointment.

[0047] Product quality and efficacy verification

[0048] Appearance: A uniform brownish-red paste, without layering or graininess, with a viscosity (25℃) of 8000 mPa·s.

[0049] Content of active ingredients: bloodwort extract ≥ 0.15 mg / g, boswellic acid ≥ 0.3 mg / g.

[0050] Example 2

[0051] A skin-regenerating and soothing ointment is prepared from the following medicinal materials in parts by weight: 35 parts of dragon's blood, 40 parts of frankincense, 45 parts of dragon bone, 35 parts of myrrh, 180 parts of gromwell root, 120 parts of cuttlebone, 90 parts of borneol, 15 parts of raw rhubarb, 20 parts of angelica, 18 parts of raw rehmannia root, 25 parts of angelica dahurica, 20 parts of notoginseng powder, 30 parts of honeysuckle vine, and 35 parts of prunella vulgaris.

[0052] The amount of sesame oil used is 10 times the total mass of the medicinal materials, and the amount of beeswax used is 5% of the mass of the filtrate after extraction of the medicinal materials and sesame oil.

[0053] Key process adjustments

[0054] Particle size of medicinal materials: 12 kinds of medicinal materials, including bloodwort and frankincense, were pulverized to 80 mesh coarse powder (compared to 100 mesh in Example 1), and the rest of the formula was the same as in Example 1.

[0055] Soaking time: Due to the increased particle size, the soaking time is extended to 8 days, with stirring twice a day to ensure that the medicinal materials are fully soaked.

[0056] Extraction time by frying: heat to 130℃ and simmer for 3 hours. The effective component extraction rate was 90.5% (meeting the requirement of ≥90%), as monitored by thin-layer chromatography.

[0057] Product Features and Application Effects

[0058] Appearance: Brownish-red ointment with a slightly granular texture (particle size ≤120μm), viscosity (25℃) is 7500mPa·s, which meets the standards for external ointments.

[0059] Applicable scenarios: More suitable for superficial wounds (such as abrasions, mild insect bite dermatitis). Because the particles are slightly coarse, they form a protective film on the wound surface faster. After use in 100 patients with superficial abrasions, the average pain relief time was 1.0 day, and the wound healing rate (7 days) reached 95%.

[0060] Example 3

[0061] A skin-regenerating and soothing ointment is prepared from the following medicinal materials in parts by weight: 30 parts of dragon's blood, 35 parts of frankincense, 40 parts of dragon bone, 32 parts of myrrh, 220 parts of gromwell root, 100 parts of cuttlebone, 120 parts of borneol, 12 parts of raw rhubarb, 22 parts of angelica, 13 parts of raw rehmannia root, 18 parts of angelica dahurica, 16 parts of notoginseng powder, 28 parts of honeysuckle vine, and 38 parts of prunella vulgaris.

[0062] The amount of sesame oil used is 10 times the total mass of the medicinal materials, and the amount of beeswax used is 5% of the mass of the filtrate after extraction of the medicinal materials and sesame oil.

[0063] Key process adjustments

[0064] Sesame oil type: Black sesame oil (acid value 0.9mg KOH / g) was used instead of white sesame oil in Example 1. Black sesame oil has a higher content of unsaturated fatty acids (≥85%) and stronger moisturizing properties.

[0065] Beeswax dosage: Because the viscosity of black sesame oil is slightly low, the amount of beeswax is adjusted to 5.5% of the filtrate mass. The rest of the formula and steps are the same as in Example 1.

[0066] Product Features and Application Effects

[0067] Appearance: Dark brownish-red paste with a gloss level superior to Example 1. Viscosity (25°C) is 8200 mPa·s, making it easier to spread when applied.

[0068] Applicable scenarios: For dry skin conditions (such as chapped hands and feet, dry phase of hormone-dependent dermatitis). After use in 50 patients with chapped hands and feet (chapped depth 0.5-1mm), the average healing time of the chapped skin was 7.2 days, and the skin moisturizing rate (24 hours after application) reached 88%, which was significantly higher than 80% in Example 1.

[0069] Safety: Black sesame oil has a lower allergenicity. In a trial involving 100 patients with allergies, the incidence of adverse reactions was only 1% (2% in Example 1), making it more suitable for people with sensitive skin.

[0070] Technological advantages:

[0071] Sesame oil, as an extraction solvent, can not only fully dissolve the fat-soluble active ingredients in medicinal materials (such as daphne in dragon's blood and boswellic acid in frankincense), but also moisturize the skin and prevent ointments from irritating the wound.

[0072] Soaking combined with deep-frying at 120-130℃ ensures the full extraction of active ingredients and kills microorganisms in the medicinal materials through high temperature, thus ensuring the safety of the ointment.

[0073] Borneol and Panax notoginseng powder are added at low temperatures to avoid high temperatures destroying their volatile components (such as borneol in borneol) and active components (such as notoginseng saponins in Panax notoginseng), thus ensuring efficacy.

[0074] Scope of application and usage of the skin-regenerating and soothing cream

[0075] 1. Scope of Application: The skin-regenerating and soothing ointment of this invention has been clinically verified to be effective in treating 20 types of skin and trauma conditions, specifically categorized as follows:

[0076] Dermatitis types: insect bite dermatitis, steroid-dependent dermatitis, photodermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis;

[0077] Wound types: pressure ulcers (stages I-IV), diabetic foot (Wagner grades I-III), burns (degree I-II), scalds (degree I-II), abrasions, lacerations, postoperative sutured wounds, and infected wounds;

[0078] Skin diseases: vulvar leukoplakia, onychomycosis (nail fungus), chapped hands and feet, eczema, acne (inflammatory papular stage), and postherpetic neuralgia (skin pain and repair).

[0079] 2. Instructions for use:

[0080] Before applying medication, clean the wound with saline or povidone-iodine to remove secretions, necrotic tissue and contaminants from the wound surface, and ensure that the wound is clean and dry.

[0081] Take an appropriate amount of Shengji Anfu Ointment (adjust the amount according to the size of the wound, generally 0.5-1mm thick), and apply it evenly to the wound or affected area, ensuring that the ointment completely covers the entire wound (avoid missing the edge areas to prevent infection);

[0082] For superficial wounds (such as abrasions and mild dermatitis), apply the medication once daily; for deep wounds (such as pressure sores and diabetic foot ulcers), apply the medication twice daily. After application, cover with sterile gauze as needed.

[0083] Precautions for using the Skin Regenerating and Soothing Cream

[0084] 1. Before applying medication, ensure the wound is clean. If the wound is severely infected (e.g., purulent discharge, necrotic tissue), debridement (e.g., removing necrotic tissue and draining pus) should be performed before applying medication.

[0085] 2. When applying the ointment, it should be evenly applied to cover the entire wound. If there is redness or inflammation at the edge of the wound, the ointment should be extended to the inflamed area (0.5-1cm beyond the edge of the wound).

[0086] 3. This invention is contraindicated for those allergic to any of the medicinal ingredients (such as dragon's blood, frankincense, borneol, etc.), and should be used with caution by those with allergic constitutions;

[0087] 4. Pregnant women, breastfeeding women, and infants should consult a doctor before use. Children should take this medication under adult supervision.

[0088] 5. The ointment should be sealed and stored in a cool, dry place (temperature ≤25℃, relative humidity ≤60%), avoiding direct sunlight. The shelf life is 24 months.

[0089] 6. If symptoms do not improve after 7 days of medication, or if the wound worsens, becomes red and swollen, or experiences increased pain, discontinue medication immediately and seek medical attention.

[0090] Experimental data and effect verification

[0091] To verify the efficacy and safety of the skin-regenerating and soothing ointment of this invention, the applicant conducted a systematic clinical trial, as detailed below:

[0092] I. Experimental Design

[0093] 1. Study Subjects: A total of 600 patients who visited the dermatology and surgery departments of three tertiary hospitals between January and December 2023 were selected. All patients were diagnosed with skin and trauma-related conditions. The specific disease distribution is as follows:

[0094] Table 1 Patient Statistics

[0095]

[0096] 2. Experimental grouping: 600 patients were randomly divided into an experimental group (using the skin-regenerating and soothing ointment of this invention) and a control group (using existing clinically commonly used drugs), with 300 patients in each group. There were no significant differences between the two groups in terms of gender, age, disease type, and disease severity (P>0.05), and they were comparable.

[0097] Experimental group: The skin-regenerating and soothing ointment of the present invention was used according to the above-described method of application;

[0098] Control group: Existing medications were used according to the type of disease, such as mometasone furoate cream for dermatitis, mupirocin ointment for wounds, and terbinafine cream for skin lesions.

[0099] Evaluation indicators:

[0100] Effectiveness indicators: symptom relief time (such as relief time for itching and pain), wound healing rate (percentage reduction in wound area), and recovery time (time for symptoms to completely disappear).

[0101] Safety indicators: Incidence of adverse reactions during medication (such as skin irritation, allergic reactions, etc.).

[0102] II. Test Results

[0103] Table 2 Comparison of Treatment Effects for Dermatitis-Related Diseases

[0104]

[0105]

[0106] Results analysis: The experimental group had significantly shorter symptom relief time and recovery time for dermatitis-related diseases than the control group, and the total effective rate (98%) was significantly higher than that of the control group (82%). Moreover, no adverse reactions such as skin atrophy or telangiectasia occurred in the experimental group, while 8 cases of skin irritation occurred in the control group (P<0.01). This indicates that the ointment of the present invention has better efficacy and higher safety in treating dermatitis-related diseases.

[0107] Table 3 Comparison of Treatment Effects for Wound-Related Diseases

[0108] Evaluation indicators Experimental group (n=100) Control group (n=125) Significance of difference (P-value) Wound healing rate (7 days, %) 65.2±8.3 42.5±7.6 ＜0.01 Wound healing rate (14 days, %) 92.3±5.1 68.7±6.8 ＜0.01 Recovery time (days) 10.5±2.3 16.8±2.5 ＜0.01 Infection control rate (%) 99 85 ＜0.01

[0109] Results analysis: The experimental group showed significantly higher wound healing rates (7 days and 14 days) and significantly shorter recovery times than the control group. Furthermore, the infection control rate (99%) was significantly higher in the experimental group than in the control group (85%). Particularly for diabetic foot patients, the recovery time in the experimental group (12.3±2.1 days) was significantly shorter than that in the control group (18.5±2.4 days) (P<0.01). This indicates that the ointment of this invention can effectively promote wound healing and control infection, and is especially suitable for difficult-to-heal wounds.

[0110] Table 4 Comparison of Treatment Effects for Skin Lesions

[0111] Evaluation indicators Experimental group (n=75) Control group (n=75) Significance of difference (P-value) Symptom relief time (days) 3.5±0.6 5.2±0.8 ＜0.01 Recovery time (days) 18.2±2.5 25.6±2.8 ＜0.01 Overall effectiveness (%) 94 76 ＜0.01 Incidence of adverse reactions (%) 2.7 10.7 ＜0.05

[0112] Results analysis: The experimental group had significantly shorter symptom relief time and recovery time for skin lesions than the control group, the total effective rate (94%) was significantly higher than that of the control group (76%), and the incidence of adverse reactions (2.7%) was significantly lower than that of the control group (10.7%) (P<0.05). This indicates that the ointment of the present invention is effective and safe in treating skin lesions.

[0113] III. Experimental Conclusions

[0114] The skin-regenerating and soothing cream of this invention, through its scientific formula and advanced preparation process, has the following advantages:

[0115] It has a wide range of indications: it can effectively treat 20 kinds of skin and trauma diseases, including dermatitis, wounds, and skin lesions, which solves the problem of the single indication of existing drugs;

[0116] Definitely effective: It can significantly shorten the time for symptom relief and recovery, improve the wound healing rate and overall effectiveness, especially for difficult-to-heal wounds (such as diabetic foot ulcers and bedsores);

[0117] High safety: Low incidence of adverse reactions, no obvious irritation or toxic side effects, avoiding problems such as skin atrophy and drug resistance of existing chemical drugs;

[0118] Good stability: Using sesame oil and beeswax as the base, the ointment has high stability, long shelf life, and is easy to promote and use in clinical practice.

[0119] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A skin-regenerating and soothing cream, characterized in that, It is prepared from the following medicinal materials in parts by weight: 30-50 parts of dragon's blood, 30-50 parts of frankincense, 30-50 parts of dragon bone, 30-50 parts of myrrh, 150-300 parts of gromwell root, 80-150 parts of cuttlebone, 80-150 parts of borneol, 10-30 parts of raw rhubarb, 10-30 parts of angelica root, 10-30 parts of raw rehmannia root, 10-30 parts of angelica dahurica, 10-30 parts of notoginseng powder, 20-40 parts of honeysuckle vine, and 20-40 parts of prunella vulgaris. It also includes essential oils and beeswax as a base.

2. The skin-regenerating and soothing cream according to claim 1, characterized in that: It is prepared from the following medicinal materials in parts by weight: 40 parts of dragon's blood, 40 parts of frankincense, 40 parts of dragon bone, 40 parts of myrrh, 200 parts of gromwell root, 100 parts of cuttlebone, 100 parts of borneol, 18 parts of raw rhubarb, 18 parts of angelica, 18 parts of raw rehmannia root, 18 parts of angelica dahurica, 18 parts of notoginseng powder, 30 parts of honeysuckle vine, and 30 parts of prunella vulgaris. The amount of sesame oil used is 10 times the total mass of the medicinal materials, and the amount of beeswax used is 5% of the mass of the filtrate after extraction of the medicinal materials and sesame oil.

3. A method for preparing the skin-regenerating and soothing cream as described in any one of claims 1-2, characterized in that, Includes the following steps: S1: Pre-treatment of medicinal materials: crush the following ingredients into coarse powder: blood dragon, frankincense, dragon bone, myrrh, gromwell root, cuttlebone, raw rhubarb, angelica, rehmannia root, angelica dahurica, honeysuckle vine, and prunella vulgaris into 80-100 mesh coarse powder; pass the notoginseng powder through a 120 mesh sieve for later use; and grind borneol into fine powder for later use. S2: Sesame oil soaking: Add the coarse powder of the 12 medicinal materials prepared in step S1 to 10 times its weight of sesame oil, seal and soak for 7 days, stirring once a day during the period; S3: Deep-frying extraction: Place the soaked herbs and sesame oil in a stainless steel pot, heat over low heat to 120-130℃, and simmer for 2-3 hours until the surface of the herbs turns yellowish-brown and emits a charred aroma. Then stop heating. S4: Filtration and slag removal: When the temperature of the liquid medicine drops to 80-90℃, filter it while it is still hot using a 300-mesh filter screen and collect the filtrate; S5: Forming and Packaging: Cool the filtrate to 60-70℃, add 5% beeswax by weight of the filtrate, stir until the beeswax is completely melted, then add the prepared Panax notoginseng powder and borneol powder, stir quickly and evenly, cool to 40-50℃, then package and seal, and cool to room temperature to obtain the final product.

4. The use of the skin-regenerating and skin-soothing ointment as described in claim 1 in the preparation of a medicament for treating skin and traumatic conditions, characterized in that... The dermatitis conditions mentioned include insect bite dermatitis, hormone-dependent dermatitis, photodermatitis, allergic dermatitis, contact dermatitis, seborrheic dermatitis, and neurodermatitis.

5. The application of the skin-regenerating and skin-soothing ointment as described in claim 1 in the preparation of drugs for treating wound-related diseases, characterized in that, The types of wounds include pressure ulcers (stages I-IV), diabetic foot ulcers, burns (superficial to deep II°), scalds (superficial to deep II°), abrasions, lacerations, post-surgical suture wounds, and infected wounds.

6. The use of the skin-regenerating and skin-soothing ointment as described in claim 1 in the preparation of a medicament for treating skin lesions, characterized in that, The skin lesions mentioned include vulvar leukoplakia, onychomycosis, vitiligo, skin ulcers, skin lesions left by postherpetic neuralgia, and eczematous dermatitis.

7. The application according to any one of claims 4-5, characterized in that, The method of using the skin-regenerating and soothing ointment is as follows: After cleaning and drying the affected skin, apply the ointment evenly to the affected area, with a thickness of 0.5-1mm, and apply 2-3 times a day; for mild cases, use the medication for 5-7 days, for moderate cases for 10-14 days, and for severe cases for 20-30 days.

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