Biological sample repository

By designing leak-proof devices and ventilation mechanisms for biological sample storage facilities, the problem of leakage of biological samples during transportation was solved, achieving the effects of biosafety and automated operation.

CN121106960APending Publication Date: 2025-12-12QINGDAO HAIER BIOMEDICAL TECH CO LTD +1
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Patent Information

Application Number
CN202511563522.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-29
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

In the existing technology, volatile biological samples are not isolated during the handling and transportation of biological samples from the vehicle compartment, resulting in direct leakage of biological samples into the operating environment, causing environmental pollution and failing to guarantee biosafety.

Method used

A biological sample storage device was designed, comprising a box, a buffer area, and a storage area. It is equipped with a leak-proof device and a ventilation mechanism to prevent biological samples in the cryopreservation box and buffer area from leaking to the outside of the box. The device is fully automated through a robotic arm to reduce the probability of human contact.

Benefits of technology

It effectively prevents leakage of biological samples, ensures the biosafety of the operating environment, reduces the risk of cross-infection and sample contamination, and achieves fully automated operation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of biological sample storage, in particular to a biological sample storage library, and aims to solve the problem that in the existing process of taking, placing and transferring volatile biological samples from a carriage, no isolation measure is taken, so that the biological samples are directly leaked to an operation environment. In order to achieve the purpose, the biological sample storage library comprises a box body, a cache region and a storage region are arranged in the box body, the storage region is used for storing cryopreservation boxes of biological samples, the cache region is used for transferring the cryopreservation boxes, and a leakage-proof device is arranged in the cache region; the anti-leakage device is arranged to be capable of preventing the biological samples in the cryopreservation box and / or the cache area from leaking to the outside of the box body, and the biological safety of the operation environment is guaranteed.
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Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological sample storage, and specifically provides a biological sample storage library. BACKGROUND

[0002] In the fields of biological medicine, biological sample library, disease control center and the like, biological safety is a core requirement in the transportation and processing process, and such samples usually need to be stored in an ultralow-temperature environment to maintain stability. For biological samples containing volatiles, the biological samples are prone to volatilization due to temperature fluctuations during the transfer process. In the existing process of taking and placing from the carriage and transportation, no isolation measures are taken, resulting in direct leakage of the biological samples to the operating environment, thereby causing environmental pollution and failing to guarantee biological safety.

[0003] Correspondingly, there is a need in the art for a new technical solution to solve the above technical problems. SUMMARY

[0004] The present application aims to solve the above technical problems, i.e., to solve the problem that, for biological samples containing volatiles, no isolation measures are taken in the process of taking and placing from the carriage and transportation, resulting in direct leakage of the biological samples to the operating environment.

[0005] The present application provides a biological sample storage library, which comprises a box body, a buffer area and a storage area are arranged in the box body, the storage area is used for storing cryopreservation boxes of the biological samples, the buffer area is used for transporting the cryopreservation boxes, a leakage prevention device is arranged in the buffer area, and the leakage prevention device is arranged to prevent the biological samples in the cryopreservation boxes and / or the buffer area from leaking to the outside of the box body.

[0006] In the above technical solution, the leakage prevention device is arranged to prevent the biological samples in the cryopreservation boxes and / or the buffer area from leaking to the outside of the box body, thereby guaranteeing the biological safety of the operating environment.

[0007] In the specific embodiment of the biological sample storage library, the leakage prevention device comprises a packaging mechanism, which is arranged to package the cryopreservation boxes to be taken out of the library, so as to prevent the biological samples in the cryopreservation boxes from leaking to the outside of the box body.

[0008] In the above technical solution, the packaging mechanism packages the cryopreservation boxes, seals the cryopreservation boxes as a whole, and thereby isolates the cryopreservation boxes from the outside. When the cryopreservation boxes are taken out of the library, the biological samples in the cryopreservation boxes can be prevented from leaking to the outside of the box body, thereby avoiding environmental pollution and guaranteeing biological safety.

[0009] In a specific embodiment of the above-described biological sample storage device, the leak prevention device further includes a ventilation mechanism. A transfer port that is connected to and disconnected from the buffer area is provided on the side wall of the housing. When the transfer port is connected to the buffer area, the ventilation mechanism is configured to draw airflow around the transfer port to prevent the biological samples in the buffer area from leaking to the outside of the housing.

[0010] In a specific embodiment of the aforementioned biological sample storage facility, the ventilation mechanism includes an exhaust duct, a guide duct, and a collection box that are interconnected. An exhaust fan is installed in the exhaust duct and / or the guide duct. The exhaust duct is arranged in a ring shape and is located at the transfer port. Multiple suction ports are provided on the exhaust duct facing the transfer port. The exhaust fan is configured to allow airflow around the transfer port to enter the exhaust duct through the multiple suction ports. The guide duct extends to the outside of the housing and can discharge the suctioned airflow to the collection box. The collection box is located on the top of the housing.

[0011] When the cryopreservation box is being moved in or out of the storage facility, the transfer port is open, allowing the buffer area to connect with the outside of the box. At this time, the exhaust fan operates, drawing air from around the transfer port through multiple suction ports into the exhaust duct. This creates a directional airflow barrier around the transfer port, preventing air from the buffer area from flowing into the outside and mitigating the risk of biological sample leakage at its source. The air then flows through the duct into the collection box for centralized collection and processing. Since there is a possibility of biological sample leakage within the buffer area of ​​the cryopreservation box, this could result in the presence of biological samples in the air within the buffer area. By implementing the exhaust mechanism, air from the buffer area can be prevented from flowing into the outside, further preventing biological samples from leaking from the cryopreservation box to the outside of the box, avoiding environmental pollution and ensuring biosafety. The directional airflow barrier around the transfer port draws in air from the area around the transfer port, preventing air from the buffer area from flowing into the outside and mitigating the risk of biological sample leakage at its source.

[0012] In a specific embodiment of the above-described biological sample storage facility, the cryopreservation box includes a box body, an upper cover connected to the top of the box body, and a lower cover connected to the bottom of the box body, forming a sealed cavity capable of storing the biological sample.

[0013] When the above technical solution is adopted, a sealed structure is formed between the box body, the upper cover and the lower cover, which plays a role in isolating the frozen samples, preventing the biological samples in the frozen box from leaking to the outside of the box body, avoiding environmental pollution and ensuring biosafety.

[0014] In the specific implementation of the above-described biological sample storage facility, in order not to hinder the scanning of the identification code on the cryopreservation tube, the upper cover and the lower cover are respectively set to transparent structures.

[0015] In the specific implementation of the above-described biological sample storage facility, a first transmission track and a second transmission track are also provided in the buffer area. The first transmission track is configured to transfer the cryopreservation box between the buffer area and the outside of the box, and the second transmission track is configured to transfer the cryopreservation box between the buffer area and the storage area. Both the first transmission track and the second transmission track are provided with a box-carrying platform for placing the cryopreservation box.

[0016] In a specific embodiment of the biological sample storage repository described above, a barcode scanning device is also provided in the buffer area, and the barcode scanning device is configured to scan and identify the cryopreservation box.

[0017] In a specific embodiment of the above-described biological sample storage facility, a robotic arm is also provided in the buffer area. The robotic arm is configured to grip the cryopreservation box and transfer it between the first transfer track, the second transfer track, the sealing mechanism, and the barcode scanning device.

[0018] In a specific embodiment of the above-described biological sample storage facility, the robotic arm includes a moving mechanism and a gripping mechanism. The driving end of the moving mechanism is connected to the gripping mechanism. The moving mechanism is configured to drive the gripping mechanism to move between the first transmission track, the second transmission track, the encapsulation mechanism, and the barcode scanning device. The gripping mechanism is configured to grip the cryopreservation box.

[0019] When the above technical solution is adopted, when the cryopreservation box is taken out of the warehouse, the cryopreservation box is first transferred to the buffer area via the second transmission track. After the cryopreservation box is scanned and identified by a robotic arm, it is transferred to the sealing mechanism. After the cryopreservation box is sealed, the robotic arm places the sealed cryopreservation box on the first transmission track and transfers it to the outside of the box. This realizes the fully automated operation of sample grabbing and sealing without manual operation, ensuring the sealing and standardization of the sealing. It can also reduce the probability of personnel directly contacting the samples, thereby reducing the risk of cross-infection or sample contamination. Attached Figure Description

[0020] The preferred embodiments of the present invention are described below with reference to the accompanying drawings, in which: Figure 1 This is a schematic diagram of the overall structure of the biological sample storage bank of the present invention; Figure 2 This is a schematic diagram of the ventilation mechanism of the biological sample storage device of the present invention; Figure 3 This is a schematic diagram of the cryopreservation box of the biological sample storage bank of the present invention; Figure 4 This is a schematic diagram of the structure of the first transport track of the biological sample storage bank of the present invention; Figure 5 This is a schematic diagram of the structure of the first transport track of the biological sample storage device of the present invention in another direction; The components are as follows: 1. Box body; 11. Buffer area; 12. Storage area; 13. Transfer port; 2. Exhaust mechanism; 21. Exhaust duct; 211. Suction port; 22. Air guide duct; 23. Collection box; 3. First transmission track; 31. Support; 32. Slide plate; 33. First horizontal movement mechanism; 331. Motor; 332. Slide rail; 333. Rack; 334. Gear; 34. Second horizontal movement mechanism; 341. Chain; 342. Sprocket; 4. Packaging mechanism; 5. Robotic arm; 51. Movement mechanism; 52. Clamping mechanism; 6. Second transmission track; 7. Box platform; 8. Cryopreservation box; 81. Box body; 82. Top cover; 83. Bottom cover; 9. Barcode scanning device. Detailed Implementation

[0021] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are merely illustrative of the technical principles of the present invention and are not intended to limit the scope of protection of the present invention. Those skilled in the art can make adjustments as needed to adapt to specific application scenarios.

[0022] It should be noted that in the description of this invention, terms such as "top" and "external" that indicate direction or positional relationship are based on the direction or positional relationship shown in the drawings. This is only for the convenience of description and is not intended to indicate or imply that the relevant device or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this invention.

[0023] Furthermore, it should be noted that, in the description of this invention, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0024] For biological samples containing volatile substances, temperature fluctuations during transfer can easily cause them to volatilize. Currently, no isolation measures are taken during the handling and transport of biological samples from the vehicle, resulting in direct leakage of biological samples into the operating environment, which in turn causes environmental pollution and fails to guarantee biosafety.

[0025] To address the aforementioned technical problems, this invention provides a biological sample storage facility. For example... Figure 1 As shown, the biological sample storage device includes a box 1, a buffer area 11 and a storage area 12 inside the box 1. The storage area 12 is used to store cryopreservation boxes 8 for biological samples, and the buffer area 11 is used to transfer cryopreservation boxes 8. The buffer area 11 is equipped with a leak-proof device, which is configured to prevent the biological samples in the cryopreservation boxes 8 and / or the buffer area 11 from leaking to the outside of the box 1.

[0026] In the above structure, by incorporating a leak-proof device, biological samples within the cryopreservation box 8 and / or buffer area 11 can be prevented from leaking to the outside of the enclosure 1, ensuring the biosafety of the operating environment. Generally, preventing biological sample leakage refers to preventing the leakage of biological samples containing hazardous substances. Of course, this is not a limitation, and those skilled in the art can apply the biological sample storage device of this invention to other biological samples as needed. All such adjustments are within the protection scope of this invention.

[0027] In some embodiments, continue as follows Figure 1 As shown, the leak prevention device includes a sealing mechanism 4, which is configured to seal the cryopreservation box 8 to be shipped out, so as to prevent the biological samples inside the cryopreservation box 8 from leaking to the outside of the box body 1.

[0028] The sealing mechanism 4 is configured as, for example, an automatic sealing machine, and adopts a structure commonly used by those skilled in the art. Its specific structure and working principle will not be described in detail here.

[0029] In the above structure, the sealing mechanism 4 encapsulates the cryopreservation box 8, sealing the entire cryopreservation box 8 and isolating it from the outside world. When the cryopreservation box 8 is taken out of the warehouse, it can prevent the biological samples inside the cryopreservation box 8 from leaking to the outside of the box 1, avoid causing environmental pollution, and ensure biological safety.

[0030] like Figure 1 and Figure 2 As shown, the leak prevention device also includes a ventilation mechanism 2. A transfer port 13 that can be connected to and disconnected from the buffer area 11 is provided on the side wall of the housing 1. When the transfer port 13 is connected to the buffer area 11, the ventilation mechanism 2 is configured to draw airflow around the transfer port 13 to prevent biological samples in the buffer area 11 from leaking to the outside of the housing 1.

[0031] An automatic door is installed at the transfer port 13. The opening and closing of the transfer port 13 is controlled by the automatic door, thereby realizing the connection and disconnection between the buffer area 11 and the outside world.

[0032] In some embodiments, the exhaust mechanism 2 includes an exhaust duct 21, a guide duct 22, and a collection box 23 that are interconnected. An exhaust fan is provided in the exhaust duct 21 and / or the guide duct 22. The exhaust duct 21 is configured in a ring shape and is located at the transfer port 13. Multiple suction ports 211 are provided on the exhaust duct 21 facing the transfer port 13. Under the action of the exhaust fan, the airflow around the transfer port 13 can enter the exhaust duct 21 through the multiple suction ports 211. The guide duct 22 extends to the outside of the housing 1 and can discharge the sucked airflow to the collection box 23. The collection box 23 is located on the top of the housing 1.

[0033] Specifically, the annular structure of the exhaust duct 21 is a closed annular structure formed around the periphery of the transfer port 13. Of course, in addition to the aforementioned annular structure, the exhaust duct 21 can also be provided on at least one side of the transfer port 13, for example, on the upper or lower side of the transfer port 13, as long as the suction port 211 on the exhaust duct 21 faces the transfer port 13. All of the above adjustments are within the scope of this invention. Of course, to ensure the suction effect, it is preferable to set the exhaust duct 21 in an annular structure, so that a directional airflow barrier can be formed at the transfer port 13, preventing air in the buffer zone 11 from flowing into the outside and causing environmental pollution.

[0034] When the cryopreservation box 8 is being moved in or out of the storage area, the transfer port 13 is open, allowing the buffer zone 11 to connect with the outside of the housing 1. At this time, the exhaust fan operates, drawing the airflow around the transfer port 13 through multiple suction ports 211 into the exhaust duct 21, and then through the guide duct 22 into the collection box 23 for centralized collection. The extracted air is then centrally processed. In this structure, since there is a possibility of biological sample leakage within the buffer zone 11 of the cryopreservation box 8, this could result in biological samples being present in the air within the buffer zone 11. By setting up the exhaust mechanism 2, the air inside the buffer zone 11 can be prevented from flowing into the outside, further preventing the biological samples inside the cryopreservation box 8 from leaking to the outside of the housing 1, avoiding environmental pollution, and ensuring biosafety.

[0035] like Figure 3 As shown, the cryopreservation box 8 includes a box body 81, an upper cover 82 connected to the top of the box body 81, and a lower cover 83 connected to the bottom of the box body 81. The box body 81, the upper cover 82, and the lower cover 83 form a sealed cavity capable of storing biological samples. The box body 81 has an opening at the top and bottom, and multiple cryopreservation holes arranged in a matrix are provided inside the box body 81. Each cryopreservation hole contains a cryopreservation tube.

[0036] In the above structure, the box body 81, the upper cover 82 and the lower cover 83 form a sealed structure, which plays a role in isolating the frozen samples, preventing the biological samples in the cryopreservation box 8 from leaking to the outside of the box body 1, avoiding environmental pollution and ensuring biosafety.

[0037] Furthermore, in order not to hinder the scanning of the identification code on the cryopreservation tube, the upper cover 82 and the lower cover 83 are both made of transparent structure.

[0038] Furthermore, the buffer area 11 is also provided with a first transmission track 3 and a second transmission track 6. The first transmission track 3 is configured to transfer the cryopreservation box 8 between the buffer area 11 and the outside of the box 1, and the second transmission track 6 is configured to transfer the cryopreservation box 8 between the buffer area 11 and the storage area 12. Both the first transmission track 3 and the second transmission track 6 are provided with a box carrier 7 for placing the cryopreservation box 8.

[0039] In some embodiments, such as Figure 4 and Figure 5 As shown, the first transmission track 3 and the second transmission track 6 have the same structure. Taking the first transmission track 3 as an example, the first transmission track 3 includes a support 31, a slide plate 32, a first horizontal moving mechanism 33, and a second horizontal moving mechanism 34. The support 31 is fixed in the buffer area 11, and the slide plate 32 is slidably connected to the support 32. The first horizontal moving mechanism 33 drives the slide plate 32 to move horizontally in a straight line. The second horizontal moving mechanism 34 is set on the slide plate 32, and the box carrier 7 is slidably set on the slide plate 32. During the movement of the slide plate 32, the second horizontal moving mechanism 34 can drive the box carrier 7 to move relative to the slide plate 32, which increases the horizontal movement distance of the box carrier 7, so that the box carrier 7 can extend to the outside of the box 1 through the transfer port 13. After retraction, the overall volume of the first transmission track 3 is small, so that the space occupied is small while transferring the cryopreservation box 8, thus reducing the space occupancy rate.

[0040] The first horizontal moving mechanism 33 includes a motor 331, a slide rail 332, a rack 333, and a gear 334. The motor 331 is fixed to the bracket 31, the slide rail 332 is slidably connected to the bracket 31, the slide plate 32 is fixed to the slide rail 332, the rack 333 is fixed to the side wall of the slide plate 32, and the output shaft of the motor 331 is fixed with a gear 334 that meshes with the rack 333. The motor 331 drives the gear 334 to rotate, thereby causing the slide plate 32 to move horizontally in a straight line.

[0041] The second horizontal moving mechanism 34 includes a chain 341 and two sprockets 342. The two sprockets 342 are rotatably connected to both ends of the slide plate 32. The chain 341 is sleeved on the sprockets 342, and the slide plate 32 passes through the inside of the chain 341, so that part of the chain 341 is above the slide plate 32 and part of the chain 341 is below the slide plate 32. A connecting block (not shown in the figure) is fixed on the lower chain 341, and the connecting block is fixedly connected to the bracket 31. During the horizontal linear movement of the slide plate 32, it drives the sprockets 342 to move forward. The sprockets 342 rotate in cooperation with the chain 341. The upper part of the chain 341 drives the carrier platform 7 to move linearly relative to the slide plate 32, thereby achieving the purpose of increasing the movement distance of the carrier platform 7, while also reducing space occupation and manufacturing costs.

[0042] Furthermore, a barcode scanning device 9 is also provided in the buffer area 11. The barcode scanning device 9 is configured to scan and identify the barcodes on the cryopreservation boxes 8. In some embodiments, the barcode scanning device 9 includes a barcode scanning box (not shown in the figure), a first camera (not shown in the figure), and a second camera (not shown in the figure). The top of the barcode scanning box has an opening, the first camera is located at the bottom of the barcode scanning box and can scan the tube barcode of the cryopreservation tube, and the second camera is located on the side of the barcode scanning box and can scan the box barcode on the side of the cryopreservation box.

[0043] Furthermore, a robotic arm 5 is also provided in the buffer area 11. The robotic arm 5 is configured to be able to grasp and transfer the cryopreservation box 8 between the first transfer track 3, the second transfer track 6, the sealing mechanism 4 and the barcode scanning device 9.

[0044] In some embodiments, the robotic arm 5 includes a moving mechanism 51 and a gripping mechanism 52. The drive end of the moving mechanism 51 is connected to the gripping mechanism 52. The moving mechanism 51 is configured to drive the gripping mechanism 52 to move between the transmission line, the encapsulation mechanism 4, and the barcode scanner 9. The gripping mechanism 52 is configured to grip the cryopreservation box 8. The moving mechanism 51 is configured as a three-axis module. The drive end of the three-axis module is connected to the gripping mechanism 52 to drive the gripping mechanism 52 to move in the XYZ three-axis directions within the buffer area 11, thereby driving the gripping mechanism 52 to move between the first transmission track 3, the second transmission track 6, the encapsulation mechanism 4, and the barcode scanner 9. The three-axis module adopts a structure conventionally used by those skilled in the art, and its specific structure and working principle will not be described in detail here.

[0045] The working principle of the present invention will be described in detail below.

[0046] When the cryopreservation box 8 is put into storage, it enters the buffer area 11 via the first transfer track 3. The robotic arm 5 transfers the cryopreservation box 8 to the barcode scanning device 9, which scans and identifies the cryopreservation box 8. Then, the robotic arm 5 places the cryopreservation box 8 on the second transfer track 6 and transfers it to the storage area 12.

[0047] When the cryopreservation box 8 is taken out of the warehouse, it is first transferred to the buffer area 11 via the second transfer track 6. The robotic arm 5 scans and identifies the cryopreservation box 8 before transferring it to the sealing mechanism 4. After the cryopreservation box 8 is sealed, the robotic arm 5 places the sealed cryopreservation box 8 on the first transfer track 3 and transfers it to the outside of the box 1. This achieves fully automated operation of sample picking and sealing without manual operation, ensuring the sealing and standardization of the sealing. It also reduces the probability of personnel directly contacting the samples, thereby reducing the risk of cross-infection or sample contamination.

[0048] As the cryopreservation box 8 enters or leaves the storage room via the transfer port 13, the exhaust mechanism 2 is activated, forming a directional airflow barrier around the transfer port 13 to draw in the airflow around the transfer port 13, preventing the air inside the buffer zone 11 from flowing into the outside, thus preventing the risk of biological sample leakage from the source.

[0049] The technical solution of the present invention has been described above with reference to the preferred embodiments shown in the accompanying drawings. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after such changes or substitutions will all fall within the scope of protection of the present invention.

Claims

1. A biological sample storage facility, characterized in that, The biological sample storage facility includes a housing (1), which contains a buffer area (11) and a storage area (12). The storage area (12) is used to store cryopreservation boxes (8) of the biological samples. The buffer area (11) is used to transfer the cryopreservation boxes (8). The buffer area (11) is equipped with a leak-proof device, which is configured to prevent the biological samples in the cryopreservation boxes (8) and / or the buffer area (11) from leaking to the outside of the housing (1).

2. The biosample storage facility according to claim 1, characterized in that, The leak prevention device includes a sealing mechanism (4), which is configured to seal the cryopreservation box (8) to be shipped out, so as to prevent the biological sample in the cryopreservation box (8) from leaking to the outside of the box (1).

3. The biological sample storage facility according to claim 1 or 2, characterized in that, The leak prevention device also includes a ventilation mechanism (2). The side wall of the box (1) is provided with a transfer port (13) that can be connected to the buffer area (11). When the transfer port (13) is connected to the buffer area (11), the ventilation mechanism (2) is configured to draw airflow around the transfer port (13) to prevent the biological sample in the buffer area (11) from leaking to the outside of the box (1).

4. The biosample storage facility according to claim 3, characterized in that, The exhaust mechanism (2) includes an exhaust duct (21), a guide duct (22), and a collection box (23) that are connected to each other. An exhaust fan is provided in the exhaust duct (21) and / or the guide duct (22). The exhaust duct (21) is arranged in a ring structure and is located at the transfer port (13). Multiple suction ports (211) are provided on the exhaust duct (21) facing the transfer port (13). The exhaust fan is configured to allow the airflow around the transfer port (13) to enter the exhaust duct (21) through the multiple suction ports (211). The guide duct (22) extends to the outside of the box (1) and can discharge the sucked airflow to the collection box (23). The collection box (23) is located on the top of the box (1).

5. The biological sample storage facility according to claim 1, characterized in that, The cryopreservation box (8) includes a box body (81), an upper cover (82) connected to the top of the box body (81), and a lower cover (83) connected to the bottom of the box body (81). A sealed cavity capable of storing the biological sample is formed between the box body (81), the upper cover (82), and the lower cover (83).

6. The biological sample storage facility according to claim 5, characterized in that, The upper cover (82) and the lower cover (83) are respectively configured as transparent structures.

7. The biological sample storage facility according to any one of claims 2 to 6, characterized in that, The buffer area (11) is also provided with a first transmission track (3) and a second transmission track (6). The first transmission track (3) is configured to transfer the cryopreservation box (8) between the buffer area (11) and the outside of the box (1). The second transmission track (6) is configured to transfer the cryopreservation box (8) between the buffer area (11) and the storage area (12). Both the first transmission track (3) and the second transmission track (6) are provided with a box carrier (7) for placing the cryopreservation box (8).

8. The biosample storage facility according to claim 7, characterized in that, The buffer area (11) is also equipped with a barcode scanning device (9), which is configured to scan and identify the cryopreservation box (8).

9. The biological sample storage facility according to claim 8, characterized in that, The buffer area (11) is also equipped with a robotic arm (5), which is configured to grip the cryopreservation box (8) and transfer it between the first transmission track (3), the second transmission track (6), the sealing mechanism (4) and the barcode scanning device (9).

10. The biosample storage facility according to claim 9, characterized in that, The robotic arm (5) includes a moving mechanism (51) and a gripping mechanism (52). The driving end of the moving mechanism (51) is connected to the gripping mechanism (52). The moving mechanism (51) is configured to drive the gripping mechanism (52) to move between the first transmission track (3), the second transmission track (6), the sealing mechanism (4), and the barcode scanning device (9). The gripping mechanism (52) is configured to grip the cryopreservation box (8).