Liquid composition for preserving contact lens

Abstract

The present disclosure provides a liquid composition for preserving contact lenses. The liquid composition includes a buffer solution, a zinc salt dissolved in the buffer solution, and a hydrophilic substance. The weight percentage concentration of the zinc salt in the liquid composition is 1 * 10 <-5 >-3%. The weight percentage concentration of the hydrophilic substance in the liquid composition is 1 * 10 <-3 >% to 3%. The liquid composition may also include a first vitamin dissolved in the buffer solution. The weight percentage concentration of the first vitamin in the liquid composition is 1 * 10 <-5 >% to 1%, and the first vitamin comprises vitamin B2, a vitamin B2 derivative, or a combination thereof. According to the present invention, the novel liquid composition is provided to preserve the contact lens, such that the contact lens wearing feeling can be effectively improved, and the health state of the cornea can be easily maintained.

Description

Technical Field

[0001] This disclosure relates to a liquid composition for use in ophthalmic products. This liquid composition can improve user comfort when wearing contact lenses and help maintain the health of the cornea. Background Technology

[0002] With the advent of the information society, the frequent use of smartphones, computers, and other 3C products has led to a continuous increase in the proportion of people suffering from myopia, and the age of onset for myopia is also gradually decreasing. Considering aesthetics and convenience, wearing contact lenses is gradually becoming a popular trend.

[0003] Since most people with poor vision have a habit of wearing contact lenses for extended periods, the comfort of wearing contact lenses is extremely important. When wearing contact lenses, factors such as oxygen permeability, moisture retention, and lubrication are all crucial indicators of comfort.

[0004] Although the materials used in contact lenses have been continuously improved, resulting in enhanced oxygen permeability, moisturizing properties, and lubrication, depending on the environment and the wearer's eye health, the wearer's eyes are prone to discomfort due to lack of oxygen and water as the wearing time increases, which may even lead to corneal injury or disease, especially when in air-conditioned rooms for extended periods.

[0005] Adding moisturizers such as glycerin to contact lens storage solutions typically only alleviates discomfort when wearing contact lenses. Therefore, there is an urgent need for a novel ophthalmic formulation to work with contact lenses to improve wearing comfort and maintain corneal health. Summary of the Invention

[0006] This disclosure provides a liquid composition for ophthalmic products. In several embodiments of this disclosure, the liquid composition can be used as a storage solution for contact lenses, meaning that when not wearing contact lenses, the user can place them in this liquid composition for storage. The liquid composition comprises a buffer solution, a zinc salt, and a hydrophilic substance. The zinc salt is dissolved in the buffer solution, and the weight percentage concentration of the zinc salt in the liquid composition is 1 x 10⁻⁶. -3 % to 3%. The hydrophilic substance is dissolved in the buffer solution, and the weight percentage concentration of the hydrophilic substance in the liquid composition is 1 x 10⁻⁶. -3 % to 3%.

[0007] In one or more embodiments disclosed herein, the zinc salt comprises zinc sulfate, zinc sulfate hydrate, zinc gluconate, zinc lactate, zinc chloride, zinc citrate, chelated zinc, zinc acetate, or combinations thereof.

[0008] In one or more embodiments disclosed herein, the buffer solution comprises borate, phosphate, or a combination thereof.

[0009] In one or more embodiments disclosed herein, the liquid composition further comprises surfactants, vitamins, or combinations thereof.

[0010] In one or more embodiments disclosed herein, the vitamins include vitamin A, vitamin A derivatives, vitamin B3, vitamin B3 derivatives, vitamin B6, vitamin B6 derivatives, vitamin B12, vitamin B12 derivatives, vitamin C, vitamin C derivatives, vitamin E, vitamin E derivatives, or combinations thereof.

[0011] In one or more embodiments disclosed herein, the vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 5%.

[0012] In one or more embodiments disclosed herein, the surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or a combination thereof.

[0013] In one or more embodiments disclosed herein, the surfactant has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -3 % to 2%.

[0014] In one or more embodiments disclosed herein, the hydrophilic material comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof.

[0015] Another aspect disclosed herein provides a liquid composition for storing contact lenses, comprising a buffer solution, a first vitamin dissolved in the buffer solution, and a hydrophilic substance. The first vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 The content of the hydrophilic substance in the liquid composition is 1% to 1%, and the first vitamin comprises vitamin B2, vitamin B2 derivatives, or a combination thereof. -3 % to 3%.

[0016] In one or more embodiments disclosed herein, the first vitamin comprises riboflavin, flavin mononucleotide and its salt, flavin adenine dinucleotide and its salt, or a combination thereof.

[0017] In one or more embodiments disclosed herein, the buffer solution comprises borate and phosphate.

[0018] In one or more embodiments disclosed herein, the liquid composition further comprises a surfactant, a second vitamin, or a combination thereof.

[0019] In one or more embodiments disclosed herein, the second vitamin comprises vitamin A, vitamin A derivative, vitamin B3, vitamin B3 derivative, vitamin B6, vitamin B6 derivative, vitamin B12, vitamin B12 derivative, vitamin C, vitamin C derivative, vitamin E, vitamin E derivative, or a combination thereof.

[0020] In one or more embodiments disclosed herein, the weight percentage concentration of the second vitamin in the liquid composition is 1 x 10⁻⁶. -5 % to 5%.

[0021] In one or more embodiments disclosed herein, the surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or a combination thereof.

[0022] In one or more embodiments disclosed herein, the surfactant has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -3 % to 2%.

[0023] In one or more embodiments disclosed herein, the hydrophilic material comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof.

[0024] Another disclosed embodiment provides a liquid composition for storing contact lenses, comprising a buffer solution, a zinc salt and a first vitamin dissolved in the buffer solution, and a hydrophilic substance. The zinc salt has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 3%. The weight percentage concentration of the first vitamin in the liquid composition is 1 x 10⁻⁶. -5 The content of the hydrophilic substance in the liquid composition is 1% to 1%, and the first vitamin comprises vitamin B2, vitamin B2 derivatives, or a combination thereof. -3 % to 3%.

[0025] In one or more embodiments disclosed herein, the zinc salt comprises zinc sulfate, zinc sulfate hydrate, zinc gluconate, zinc lactate, zinc chloride, zinc citrate, chelated zinc, zinc acetate, or combinations thereof.

[0026] In one or more embodiments disclosed herein, the first vitamin comprises riboflavin, flavin mononucleotide and its salt, flavin adenine dinucleotide and its salt, or a combination thereof.

[0027] In one or more embodiments disclosed herein, the buffer solution comprises borate, phosphate, or a combination thereof.

[0028] In one or more embodiments disclosed herein, the liquid composition further comprises a surfactant, a second vitamin, or a combination thereof.

[0029] In one or more embodiments disclosed herein, the second vitamin comprises vitamin A, vitamin A derivative, vitamin B3, vitamin B3 derivative, vitamin B6, vitamin B6 derivative, vitamin B12, vitamin B12 derivative, vitamin C, vitamin C derivative, vitamin E, vitamin E derivative, or a combination thereof.

[0030] In one or more embodiments disclosed herein, the weight percentage concentration of the second vitamin in the liquid composition is 1 x 10⁻⁶. -5 % to 5%.

[0031] In one or more embodiments disclosed herein, the surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or a combination thereof.

[0032] In one or more embodiments disclosed herein, the surfactant has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -3 % to 2%.

[0033] In one or more embodiments disclosed herein, the hydrophilic material comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof. Detailed Implementation

[0034] To make the description of this disclosure more detailed and complete, illustrative descriptions of embodiments and specific examples of this disclosure are provided below; however, these are not the only forms of implementing or utilizing the specific examples of this disclosure. The various embodiments disclosed below can be combined or substituted with each other where advantageously possible, and other embodiments can be added to one embodiment without further description or explanation. In the following description, many specific details will be set forth in detail to enable the reader to fully understand the following embodiments. However, the embodiments of this disclosure can be practiced without such specific details.

[0035] Unless the context otherwise requires, throughout this specification and the scope of the claims, the term "comprising" shall be understood as an open-ended term, meaning "including but not limited to". Furthermore, unless otherwise defined, the terms used herein have the same meaning as understood by one of ordinary skill in the art to which this disclosure pertains.

[0036] This disclosure provides a liquid composition for use in ophthalmic products. In several embodiments of this disclosure, the liquid composition can be used as a storage solution for contact lenses, meaning that users can place contact lenses in this liquid composition for storage when not wearing them.

[0037] The liquid composition includes a buffer solution and a zinc salt. In one or more embodiments disclosed herein, the buffer solution includes a borate and a phosphate. The borate may be, for example, sodium tetraborate, but is not limited thereto. The phosphate may be, for example, sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, but is not limited thereto. In one or more embodiments disclosed herein, the buffer solution further includes boric acid, sodium chloride, or combinations thereof, but is not limited thereto.

[0038] The zinc salt dissolves in a buffer solution and can release zinc ions in the buffer solution. In one or more embodiments disclosed herein, the zinc salt comprises, but is not limited to, zinc sulfate, zinc sulfate hydrate, zinc gluconate, zinc lactate, zinc chloride, zinc citrate, chelated zinc, zinc acetate, or combinations thereof. The weight percentage concentration of the zinc salt in the liquid composition is 1 x 10⁻⁶. -5 % to 3%, preferably 5x10 -5 % to 2%, for example, 5x10 -4 %, 1x10 -4 %, 5x10 -3 %, 1x10 -3 %, 0.05%, 0.01%, 0.5% or 0.1%. It is worth noting that when the weight percentage concentration of zinc salt in the liquid composition is within the above range or value, it will bring about unpredictable technical effects, which will be described in more detail later.

[0039] In one or more embodiments of this disclosure, the liquid composition further comprises a hydrophilic substance, a surfactant, a vitamin, or a combination thereof. In one or more embodiments of this disclosure, the hydrophilic substance comprises, but is not limited to, polyvinyl alcohol, cellulose, cellulose derivatives, polyvinylpyrrolidone, hyaluronic acid, polyglutamic acid, 2-methacryloyloxyethyl phosphocholine, polymers of phosphocholine groups, polyethylene glycol, or a combination thereof. In one or more embodiments of this disclosure, the weight percentage concentration of the hydrophilic substance in the liquid composition is 1 x 10⁻⁶. -3 % to 3%, preferably 5x10 -3% to 2.5%, for example, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 1.5% or 2%.

[0040] In one or more embodiments disclosed herein, the surfactant comprises, but is not limited to, polyoxyethylene (20) sorbitan monolaurate (Tween 20), polyoxyethylene sorbitan monostearate (Tween 60), polyoxyethylene sorbitan monooleate (Tween 80), sodium lauroyl lactylate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, sodium dodecyl sulfate, alkyl sulfosuccinate (GEROPON® SBFA-30), or combinations thereof. In one or more embodiments disclosed herein, the surfactant has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -3 % to 2%, preferably 5x10 -3 % to 1%, for example, 0.01%, 0.05% or 0.5%.

[0041] In one or more embodiments disclosed herein, the vitamin comprises vitamin A, vitamin A derivatives, vitamin B3, vitamin B3 derivatives, vitamin B6, vitamin B6 derivatives, vitamin B12, vitamin B12 derivatives, vitamin C, vitamin C derivatives, vitamin E, vitamin E derivatives, or combinations thereof. In one or more embodiments disclosed herein, the vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 5%, preferably 5x10 -5 % to 3%, for example, 1x10 -4 %, 5x10 -4 %, 1x10 -3 %, 5x10 -3 %, 0.01%, 0.05%, 0.1%, 0.5%, 1%, or 2%. It is worth noting that when the weight percentage concentration of the above vitamins in the liquid composition is within the above range or value, it will bring about unpredictable technical effects, which will be described in more detail later.

[0042] Another aspect of this disclosure provides a liquid composition for an ophthalmic product, comprising a buffer solution and a first vitamin dissolved in the buffer solution. In one or more embodiments of this disclosure, the buffer solution comprises a borate, a phosphate, or a combination thereof. Materials for borates and phosphates have been provided as described above and will not be repeated here. In one or more embodiments of this disclosure, the buffer solution further comprises boric acid, sodium chloride, or a combination thereof, but is not limited thereto.

[0043] The first vitamin includes vitamin B2, vitamin B2 derivatives, or combinations thereof. The structure of vitamin B2 derivatives can be shown by formula (I): Formula (I), Wherein R represents a hydroxyl group, a phosphate group, or a phosphate-containing derivative. Vitamin B2 derivatives may be, for example, flavin mononucleotides, flavin adenine dinucleotides, but are not limited thereto. In one or more embodiments disclosed herein, the first vitamin comprises riboflavin, flavin mononucleotides and their salts, flavin adenine dinucleotides and their salts, or combinations thereof. The weight percentage concentration of the first vitamin in the liquid composition is 1 x 10⁻⁶. -5 % to 1%, preferably 5x10 -5 % to 0.5%, for example, 1x10 -4 %, 5x10 -4 %, 1x10 -3 %, 5x10 -3 %, 0.01%, 0.05%, or 0.1%. It is worth noting that when the weight percentage concentration of the first vitamin in the liquid composition is within the above range or value, it will bring about unpredictable technical effects, which will be described in more detail later.

[0044] In one or more embodiments disclosed herein, the liquid composition further comprises a hydrophilic substance, a surfactant, a second vitamin, or a combination thereof. The materials of the hydrophilic substance and the surfactant, and their individual weight percentage concentrations in the liquid composition, have been provided above and will not be repeated here.

[0045] In one or more embodiments disclosed herein, the second vitamin comprises vitamin A, a vitamin A derivative, vitamin B3, a vitamin B3 derivative, vitamin B6, a vitamin B6 derivative, vitamin B12, a vitamin B12 derivative, vitamin C, a vitamin C derivative, vitamin E, a vitamin E derivative, or a combination thereof. In one or more embodiments disclosed herein, the second vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 5%, preferably 5x10 -5 % to 3%, for example, 1x10 -4 %, 5x10 -4 %, 1x10 -3%, 5x10 -3 %, 0.01%, 0.05%, 0.1%, 0.5%, 1%, or 2%. It is worth noting that when the weight percentage concentration of the second vitamin in the liquid composition is within the above ranges or values, it will bring about unpredictable technical effects, which will be described in more detail later.

[0046] Another aspect of this disclosure provides a liquid composition for an ophthalmic product, comprising a buffer solution and a zinc salt and a first vitamin dissolved in the buffer solution. In one or more embodiments of this disclosure, the buffer solution comprises a borate, a phosphate, or a combination thereof. Materials for borates and phosphates have been provided as described above and will not be repeated here. In one or more embodiments of this disclosure, the buffer solution further comprises boric acid, sodium chloride, or a combination thereof, but is not limited thereto.

[0047] Zinc salts dissolve in buffer solutions and can release zinc ions in the buffer solutions. In one or more embodiments disclosed herein, the materials of the zinc salts and their weight percentage concentrations in the liquid composition have been provided as described above and will not be repeated here. It is worth noting that when the weight percentage concentration of the zinc salt in the liquid composition is within the above-described range or values, unforeseen technical effects will occur, which will be further described later.

[0048] The first vitamin comprises vitamin B2, vitamin B2 derivatives, or combinations thereof. The structures of vitamin B2 and vitamin B2 derivatives and their weight percentage concentrations in the liquid composition have been provided above and will not be repeated here. It is worth noting that when the weight percentage concentration of the first vitamin in the liquid composition is within the above-mentioned range or values, unforeseen technical effects will occur, which will be described in more detail later.

[0049] In one or more embodiments disclosed herein, the liquid composition further comprises a hydrophilic substance, a surfactant, a second vitamin, or a combination thereof. The materials of the hydrophilic substance, surfactant, and second vitamin, and their individual weight percentage concentrations in the liquid composition, have been provided above and will not be repeated here.

[0050] Three sets of embodiments and one set of comparative examples will be provided subsequently. The embodiments provided are intended to illustrate specific aspects of this disclosure and to enable those skilled in the art to implement this disclosure, and should not be construed as limiting this disclosure.

[0051] In both the examples and comparative examples, the subjects wore the same type of contact lenses. The main difference between the examples and the comparative examples is that the contact lenses in the examples were pre-stored in the liquid composition disclosed herein, while the contact lenses in the comparative examples were pre-stored in other liquid compositions. It is worth noting that the liquid composition disclosed herein contains one or a combination of zinc salts, vitamin B2, and vitamin B2 derivatives; however, the liquid composition used for pre-stored contact lenses in the comparative examples does not contain any of zinc salts, vitamin B2, and vitamin B2 derivatives.

[0052] The first set of embodiments includes Examples A1 to A12. Table 1 records the specific components of Examples A1 to A12 and their weight percentage concentrations (in %) in the liquid composition, which may include: 1. Buffer solution: The buffer solution contains sodium tetraborate, boric acid and sodium chloride.

[0053] 2. Hydrophilic substances: Hyaluronic acid and polyvinyl alcohol (PEG400) with an average molecular weight of 400.

[0054] 3. Surfactant: Polyoxyethylene sorbitan monooleate (Tween 80), with a weight percentage concentration of 0.08% in the liquid composition.

[0055] 4. Zinc salts: zinc sulfate, zinc lactate.

[0056] 5. Vitamins: Vitamin B6, Vitamin B12, Vitamin E.

[0057] In Examples A1 to A3, the liquid composition contains either zinc sulfate or zinc lactate, and the weight percentage concentration of zinc sulfate or zinc lactate in the liquid composition is 0.001%. Furthermore, Example A1 does not contain hyaluronic acid, PEG400, and TWEEN 80, while Examples A2 to A3 contain hyaluronic acid, PEG 400, and TWEEN 80.

[0058] The compositions and weight percentage concentrations of Examples A4 to A6 are generally similar to those of Example A2, except that Examples A4 to A6 contain both zinc sulfate and zinc lactate. In Examples A4 to A6, the individual weight percentage concentrations of zinc sulfate and zinc lactate in the liquid composition are 0.001%, 0.25%, and 1%, respectively.

[0059] The composition and weight percentage concentration of Examples A7 to A8 are generally similar to those of Example A5, except that Example A7 further contains vitamin B6 and vitamin B12, and Example A8 further contains vitamin B6, vitamin B12 and vitamin E.

[0060] The composition and weight percentage concentration of Example A9 are generally similar to those of Example A6, except that Example A9 further contains vitamin B6, vitamin B12 and vitamin E.

[0061] The composition and weight percentage concentration of Examples A10 to A12 are generally similar to those of Example A8, except that Example A10 does not contain hyaluronic acid, Example A11 does not contain hyaluronic acid and PEG 400, and Example A12 does not contain hyaluronic acid, PEG 400 and TWEEN 80.

[0062] The comparative examples include Comparative Examples B1 to B3. The composition and weight percentage concentration of Comparative Examples B1, B2, and B3 are substantially similar to those of Examples A1, A2, and A8, respectively, except that Comparative Examples B1 to B3 completely lack both zinc sulfate and zinc lactate. Table 2 shows the specific components of Comparative Examples B1 to B3 and their weight percentage concentrations (in %) in the liquid composition.

[0063] Table 1 Table 2

[0064] The following uses the Visual Analogue Scale (VAS), a commonly used method in the art, to measure the self-perceived symptoms of five subjects after wearing contact lenses containing the liquid compositions shown in Tables 1 (Examples A1 to A12) and 2 (Comparative Examples B1 to B3). Evaluation items included comfort, moisture level, visual clarity, and absence of foreign body sensation. Each evaluation item was further subdivided into evaluations immediately after wearing the contact lenses, 1 hour after wearing them, 4 hours after wearing them, and 8 hours after wearing them. Self-perceived symptoms were rated on a scale of 1 to 10, with higher values ​​indicating better symptoms and lower values ​​indicating worse symptoms. Table 3 shows the results of the subjects' self-perceived symptoms after wearing the contact lenses.

[0065] Table 3

[0066] As shown in Table 3, compared to Comparative Example B1, Example A1 achieved higher scores in self-perceived symptoms regarding comfort, hydration, visual clarity, and absence of foreign body sensation. Table 3 also shows that regardless of whether the subjects were immediately after wearing contact lenses, 1 hour after wearing them, 4 hours after wearing them, or 8 hours after wearing them, Example A1 consistently scored higher than Comparative Example B1 in the aforementioned self-perceived symptoms evaluations. Similarly, Examples A2 and A8 also achieved higher self-perceived symptoms evaluation scores than Comparative Examples B2 and B3, respectively.

[0067] It is noteworthy that, in Examples A1 to A3 (containing either zinc sulfate or zinc lactate), Examples A4 to A6 (containing both zinc sulfate and zinc lactate), Example A7 (containing both zinc sulfate and zinc lactate, and also vitamin B6 and vitamin B12), and Example A8 (containing both zinc sulfate and zinc lactate, and also vitamin B6, vitamin B12, and vitamin E), the subjects' self-reported symptoms regarding comfort, moisture, visual clarity, and absence of foreign body sensation were significantly better than those in Comparative Examples B1 to B3.

[0068] Accordingly, this disclosure provides a novel liquid composition for storing contact lenses, wherein by adding a specific amount of zinc salt and optionally certain types of vitamins, subjects can achieve better comfort, hydration, visual clarity, and a foreign body sensation when wearing contact lenses.

[0069] Furthermore, it is noteworthy that, in the absence of hyaluronic acid, PEG 400, and / or TWEEN 80 (see Examples A10 to A12), the subjects' self-reported symptoms were significantly better than those in Comparative Examples B1 to B3. This demonstrates that, even without hydrophilic substances and / or surfactants, the novel liquid composition disclosed herein for preserving contact lenses can provide subjects with better comfort, hydration, visual clarity, and a feeling of no foreign body sensation when wearing contact lenses.

[0070] The second set of embodiments includes Examples C1 to C12. The specific components of Examples C1 to C12 are generally similar to those of Examples A1 to A12, the difference being that Examples C1 to C12 do not contain zinc sulfate and / or zinc lactate, but instead contain flavin mononucleotide and / or flavin adenine dinucleotide, and the individual weight percentage concentrations of flavin mononucleotide and / or flavin adenine dinucleotide in the liquid composition are varied. Those skilled in the art will understand that flavin mononucleotide and flavin adenine dinucleotide are some examples of vitamin B2 derivatives. Table 4 shows the specific components of Examples C1 to C12 and their weight percentage concentrations (in %) in the liquid composition.

[0071] Similarly, the visual analogue scale, commonly used in this field, was used to measure the self-perceived symptoms of the five subjects after wearing contact lenses containing the liquid composition shown in Table 4. The specific details of the evaluation items have been described above and will not be repeated here. Table 5 shows the evaluation results of the subjects' self-perceived symptoms after wearing contact lenses.

[0072] As shown in Table 5, compared to Comparative Example B1, Example C1 achieved higher scores in self-perceived symptoms regarding comfort, moisture level, visual clarity, and absence of foreign body sensation. Table 5 also shows that regardless of whether the subjects were immediately after wearing contact lenses, 1 hour after wearing them, 4 hours after wearing them, or 8 hours after wearing them, Example C1 consistently scored higher than Comparative Example B1 in the aforementioned self-perceived symptoms evaluations. Similarly, Examples C2 and C8 also achieved higher self-perceived symptoms evaluation scores than Comparative Examples B2 and B3, respectively.

[0073] It is noteworthy that, in Examples C1 to C3 (containing one of flavin mononucleotide and / or flavin adenine dinucleotide), Examples C4 to C6 (containing both flavin mononucleotide and / or flavin adenine dinucleotide), Example C7 (containing vitamin B6 and vitamin B12 in addition to flavin mononucleotide and / or flavin adenine dinucleotide), and Example C8 (containing vitamin B6, vitamin B12, and vitamin E in addition to flavin mononucleotide and / or flavin adenine dinucleotide), the subjects' self-reported symptoms regarding comfort, moisture retention, visual clarity, and absence of foreign body sensation were significantly better than those in Comparative Examples B1 to B3. Therefore, this disclosure provides a novel liquid composition for preserving contact lenses, wherein by adding specific amounts of flavin mononucleotide and / or flavin adenine dinucleotide and optionally certain other types of vitamins, subjects can achieve better comfort, moisture retention, visual clarity, and absence of foreign body sensation when wearing contact lenses.

[0074] Furthermore, in the absence of hyaluronic acid, PEG 400, and / or TWEEN 80 (see Examples C10 to C12), the subjects' self-reported symptoms were significantly better than those in Comparative Examples B1 to B3. This demonstrates that, even without hydrophilic substances and / or surfactants, the novel liquid composition disclosed herein for preserving contact lenses can provide subjects with better comfort, hydration, visual clarity, and a feeling of no foreign body sensation when wearing contact lenses.

[0075] Table 4 Table 5

[0076] The third set of examples includes Examples D1 to D4. Table 6 records the specific components of Examples D1 to D4 and their weight percentage concentrations (in %) in the liquid composition. As shown in Table 6, each of Examples D1 to D4 contains 0.20% zinc sulfate, 0.05% zinc lactate, and 0.05% flavin mononucleotide, while Comparative Examples B1 to B3 do not contain any of zinc sulfate, zinc lactate, or flavin mononucleotide.

[0077] Similarly, the visual analogue scale, commonly used in this field, was used to measure the self-perceived symptoms of the five subjects after wearing contact lenses containing the liquid composition shown in Table 6. The specific details of the evaluation items have been described above and will not be repeated here. Table 7 shows the evaluation results of the subjects' self-perceived symptoms after wearing contact lenses.

[0078] As shown in Table 7, compared to Comparative Examples B1 to B3, Examples D1 to D4 achieved higher scores in self-reported symptoms regarding comfort, moisture retention, visual clarity, and the absence of foreign body sensation. In other words, the novel liquid composition disclosed herein for preserving contact lenses, containing zinc sulfate, zinc lactate, flavin mononucleotide, and optionally certain other types of vitamins, provides subjects with better comfort, moisture retention, visual clarity, and the absence of foreign body sensation when wearing contact lenses. Furthermore, Example D1 also demonstrates that even without hyaluronic acid and PEG 400, the subjects' self-reported symptoms were significantly better than those in Comparative Examples B1 to B3.

[0079] Table 6 Table 7

[0080] In summary, this disclosure provides a liquid composition for ophthalmic products, such as a liquid composition for storing contact lenses. This liquid composition contains specific amounts of zinc salts, vitamin B2, and / or vitamin B2 derivatives. The zinc salts release zinc ions in a buffer solution of the liquid composition. Multiple experiments have demonstrated that when subjects wear contact lenses pre-stored in the liquid composition of this disclosure, they experience better comfort, moisture retention, visual clarity, and a lack of foreign body sensation. Furthermore, subjects continue to experience good comfort, moisture retention, visual clarity, and a lack of foreign body sensation immediately after wearing the contact lenses, after 1 hour, 4 hours, and 8 hours. In other words, this disclosure, by providing a novel liquid composition for storing contact lenses, effectively improves the subject's experience when wearing contact lenses and helps maintain the health of the subject's cornea.

[0081] The foregoing outlines the features of several embodiments or examples to enable those skilled in the art to better understand the nature of this disclosure. Those skilled in the art should understand that they can readily use this disclosure as a basis for designing or modifying other processes and structures to perform the same purposes and / or achieve the same advantages as the embodiments described herein. Those skilled in the art should also recognize that these equivalent constructions do not depart from the spirit and scope of this disclosure, and that various changes, substitutions, and modifications can be made herein without departing from the spirit and scope of this disclosure.

Claims

1. A liquid composition for storing contact lenses, characterized in that, Include: Buffer solution; A zinc salt is dissolved in the buffer solution, wherein the weight percentage concentration of the zinc salt in the liquid composition is 1 x 10⁻⁶. -5 % to 3%; as well as A hydrophilic substance is dissolved in the buffer solution, wherein the weight percentage concentration of the hydrophilic substance in the liquid composition is 1 x 10⁻⁶. -3 % to 3%.

2. The liquid composition according to claim 1, characterized in that, The zinc salt comprises zinc sulfate, zinc sulfate hydrate, zinc gluconate, zinc lactate, zinc chloride, zinc citrate, chelated zinc, zinc acetate, or combinations thereof.

3. The liquid composition according to claim 1, characterized in that, The buffer solution contains borate, phosphate, or a combination thereof.

4. The liquid composition according to claim 1, characterized in that, It also contains surfactants, vitamins, or combinations thereof.

5. The liquid composition according to claim 4, characterized in that, This vitamin includes vitamin A, vitamin A derivatives, vitamin B3, vitamin B3 derivatives, vitamin B6, vitamin B6 derivatives, vitamin B12, vitamin B12 derivatives, vitamin C, vitamin C derivatives, vitamin E, vitamin E derivatives, or combinations thereof.

6. The liquid composition according to claim 4, characterized in that, The vitamin has a weight percentage concentration of 1 x 10⁻⁶ in this liquid composition. -5 % to 5%.

7. The liquid composition according to claim 4, characterized in that, The surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or combinations thereof.

8. The liquid composition according to claim 4, characterized in that, The surfactant has a weight percentage concentration of 1 x 10⁻⁶ in this liquid composition. -3 % to 2%.

9. The liquid composition according to claim 1, characterized in that, The hydrophilic substance comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof.

10. A liquid composition for storing contact lenses, characterized in that, Include: Buffer solution; The first vitamin is dissolved in the buffer solution, wherein the weight percentage concentration of the first vitamin in the liquid composition is 1 x 10⁻⁶. -5 % to 1%, and the first vitamin includes vitamin B2, vitamin B2 derivatives, or a combination thereof; as well as A hydrophilic substance is dissolved in the buffer solution, wherein the weight percentage concentration of the hydrophilic substance in the liquid composition is 1 x 10⁻⁶. -3 % to 3%.

11. The liquid composition according to claim 10, characterized in that, This first vitamin contains riboflavin, flavin mononucleotide and its salts, flavin adenine dinucleotide and its salts, or combinations thereof.

12. The liquid composition according to claim 10, characterized in that, This buffer solution contains borate and phosphate.

13. The liquid composition according to claim 10, characterized in that, It also contains surfactants, a second vitamin, or a combination thereof.

14. The liquid composition according to claim 13, characterized in that, The second vitamin includes vitamin A, vitamin A derivatives, vitamin B3, vitamin B3 derivatives, vitamin B6, vitamin B6 derivatives, vitamin B12, vitamin B12 derivatives, vitamin C, vitamin C derivatives, vitamin E, vitamin E derivatives, or combinations thereof.

15. The liquid composition according to claim 13, characterized in that, The second vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 5%.

16. The liquid composition according to claim 13, characterized in that, The surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or combinations thereof.

17. The liquid composition according to claim 13, characterized in that, The surfactant has a weight percentage concentration of 1 x 10⁻⁶ in this liquid composition. -3 % to 2%.

18. The liquid composition according to claim 10, characterized in that, The hydrophilic substance comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof.

19. A liquid composition for storing contact lenses, characterized in that, Include: Buffer solution; A zinc salt is dissolved in the buffer solution, wherein the weight percentage concentration of the zinc salt in the liquid composition is 1 x 10⁻⁶. -5 % to 3%; The first vitamin is dissolved in the buffer solution, wherein the weight percentage concentration of the first vitamin in the liquid composition is 1 x 10⁻⁶. -5 % to 1%, and the first vitamin includes vitamin B2, vitamin B2 derivatives, or a combination thereof; as well as A hydrophilic substance is dissolved in the buffer solution, wherein the weight percentage concentration of the hydrophilic substance in the liquid composition is 1 x 10⁻⁶. -3 % to 3%.

20. The liquid composition according to claim 19, characterized in that, The zinc salt comprises zinc sulfate, zinc sulfate hydrate, zinc gluconate, zinc lactate, zinc chloride, zinc citrate, chelated zinc, zinc acetate, or combinations thereof.

21. The liquid composition according to claim 19, characterized in that, This first vitamin contains riboflavin, flavin mononucleotide and its salts, flavin adenine dinucleotide and its salts, or combinations thereof.

22. The liquid composition according to claim 19, characterized in that, The buffer solution contains borate, phosphate, or a combination thereof.

23. The liquid composition according to claim 19, characterized in that, It also contains surfactants, a second vitamin, or a combination thereof.

24. The liquid composition according to claim 23, characterized in that, The second vitamin includes vitamin A, vitamin A derivatives, vitamin B3, vitamin B3 derivatives, vitamin B6, vitamin B6 derivatives, vitamin B12, vitamin B12 derivatives, vitamin C, vitamin C derivatives, vitamin E, vitamin E derivatives, or combinations thereof.

25. The liquid composition according to claim 23, characterized in that, The second vitamin has a weight percentage concentration of 1 x 10⁻⁶ in the liquid composition. -5 % to 5%.

26. The liquid composition according to claim 23, characterized in that, The surfactant comprises polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, sodium lauroyl lactylate, polypropylene glycol, sodium dodecyl sulfate, alkyl sulfosuccinate, or combinations thereof.

27. The liquid composition according to claim 23, characterized in that, The surfactant has a weight percentage concentration of 1 x 10⁻⁶ in this liquid composition. -3 % to 2%.

28. The liquid composition according to claim 19, characterized in that, The hydrophilic substance comprises a combination of polyvinyl alcohol and hyaluronic acid with an average molecular weight of 400, polyvinyl alcohol with an average molecular weight of 400, polyvinylpyrrolidone, a polymer of phosphocholine groups, or a combination thereof.

Images