Ion-resistant liposome as well as preparation method and application thereof
Through specific formulations and preparation methods, the prepared ion-resistant liposomes have stable particle size in a metal ion environment, solving the problems of easy aggregation and single efficacy of traditional liposomes, and achieving highly efficient moisturizing and antioxidant effects.
Patent Information
- Application Number
- CN202511482178.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-16
- Publication Date
- 2025-12-16
AI Technical Summary
Traditional liposomes tend to aggregate and have unstable particle size in environments containing metal ions, and their moisturizing and antioxidant effects are poor, failing to meet the high-performance requirements of high-end cosmetics and pharmaceuticals.
A specific ratio of lecithin and polyglycerol-10 myristate was used to formulate ion-resistant liposomes, which were then combined with active ingredients such as roselle flower extract, pissula fruit water, apricot kernel extract, salsa seed oil, winged fruit oil and euphorbia seed extract. These liposomes enhanced interfacial stability and antioxidant properties.
The prepared liposomes have stable particle size in a metal ion environment and exhibit excellent moisturizing and antioxidant effects, thereby enhancing the skincare efficacy of cosmetics.
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Abstract
Description
TECHNICAL FIELD
[0001] The application belongs to the technical field of liposome preparation, and particularly relates to an ion-resistant liposome and a preparation method and application thereof. BACKGROUND
[0002] Liposomes have good biocompatibility due to their similar structure to biological membranes. Due to their unique structure, liposomes can encapsulate both hydrophilic and hydrophobic substances, and therefore are widely used in the fields of cosmetics, food, drug delivery, etc. In the field of cosmetics, liposomes can be used as carriers of functional ingredients (such as moisturizers, antioxidants, whitening agents, etc.), to improve the skin penetration of the ingredients, protect them from inactivation, and achieve sustained release, thereby enhancing the skin care effect. However, traditional liposomes, especially those composed of a single phospholipid such as lecithin, have obvious technical bottlenecks in practical application, mainly manifested in weak ion resistance and single skin care effect; for example, in an environment containing metal ions such as sodium, calcium and magnesium, traditional liposomes are prone to aggregation and have unstable particle size; and for example, liposomes composed of a single lecithin have difficulty in simultaneously having the functions of moisturizing and antioxidant. Therefore, there is an urgent need to develop a new type of liposome that not only effectively resists the interference of ions in the environment, but also provides excellent moisturizing and antioxidant effects, so as to meet the demand for high-performance liposomes in the fields of high-end cosmetics, pharmaceuticals, etc. SUMMARY
[0003] The purpose of the present application is to provide an ion-resistant liposome and a preparation method and application thereof, which solve the problems of weak ion resistance and poor moisturizing and antioxidant effects of the liposomes in the prior art.
[0004] The purpose of the present application can be achieved by the following technical solutions: The ion-resistant liposome provided in the first aspect of the present application comprises the following raw materials by weight: 70-75 parts by weight of a water-phase active component, 18.7-20 parts by weight of an oil-phase active component, and 4.7-5 parts by weight of a film material.
[0005] According to a preferred technical solution of the present application, the water-phase active component comprises active substances, deionized water and polyhydric alcohol in a mass ratio of 1:5.5-6:11-12.
[0006] Further, the active substances comprise rose brier flower extract and bael fruit water in a mass ratio of 12-13:1. Rose brier (HIBISCUS SABDARIFFA) flower extract: contains organic acid components such as malic acid, tartaric acid, citric acid, succinic acid, etc., which can promote the renewal of keratinocytes and help winged fruit oil to make the skin barrier more stable; Terminalia bellirica fruit water: contains tannins, flavonoids, gallic acid, ellagic acid and various phenolic compounds, can scavenge various free radicals such as nitric oxide, superoxide anion, DPPH and hydroxyl radicals by providing hydrogen atoms, and has excellent antioxidant properties.
[0007] Further, the polyol includes at least one of sorbitol, glycerol, propylene glycol, 1,3-propanediol, methylpropanediol, dipropylene glycol, butanediol, pentanediol, 1,2-hexanediol.
[0008] Preferably, the polyol includes glycerol and 1,3-propanediol in a mass ratio of 6-8:1.
[0009] As a preferred technical solution of the present application, the oil phase active ingredient includes at least one of Prunus japonica extract, Shorea stenoptera seed butter, Elaeagnus mollis diel oil, Adansonia digitata seed extract, squalane, caprylic / capric triglyceride, argania spinosa kernel oil, aleurites fordii oil, camellia sinensis seed oil, simmondsia chinensis seed oil, shea butter, tocopheryl acetate.
[0010] Preferably, the oil phase active ingredient includes Prunus japonica extract, Shorea stenoptera seed butter, Elaeagnus mollis diel oil, Adansonia digitata seed extract, squalane, caprylic / capric triglyceride in a mass ratio of 1-1.2:4-5:1-3:2-3:15-21:15-24; Prunus japonica extract: contains active ingredients such as amygdalin, natural oil, phenolic acid, crude protein, cellulose, phytosterol, and vitamins, can effectively regulate the expression of moisture factors, help the skin to supplement water, and improve the skin condition; Shorea stenoptera seed butter: a lipid refined from Shorea stenoptera seed particles, mainly composed of fatty acids and triglycerides, has the effects of moisturizing the skin and forming a protective film, can help to lock in water and provide long-lasting relief from dryness, and improve the smoothness of the skin; Elaeagnus mollis diel oil: rich in amino acids, unsaturated fatty acids, flavonoids, vitamins, phytosterols and sugars, can promote the expression of keratin 10 and filaggrin, help to improve the skin barrier function, has auxiliary repair effect on dry and itchy skin and cracked skin, in addition, also has the effects of reducing lipid peroxidation, activating Nrf2 pathway, and improving antioxidant effect; Celastrus paniculatus seed extract: contains various chemical components with antioxidant effects, such as phytosterols, sesquiterpenes, polyphenols and flavonoids, etc., can reduce free radical level and induce catalase activity to achieve antioxidant effect.
[0011] As a preferred technical solution of the present application, the film material comprises at least one of lecithin and hydrogenated lecithin, and at least one of polyglyceryl-10 laurate and polyglyceryl-10 myristate.
[0012] Preferably, the film material comprises lecithin, and polyglyceryl-10 laurate or polyglyceryl-10 myristate.
[0013] More preferably, the film material comprises lecithin, polyglyceryl-10 myristate, and the mass ratio is 8-9:1.5-2.
[0014] The application provides a preparation method of ion-resistant liposomes. (1) Mix and control-temperature stir the water-phase active components uniformly, and keep warm to obtain a water-phase solution; (2) Mix and control-temperature stir the oil-phase active components and the film material uniformly, and keep warm to obtain an oil-phase solution; (3) Control the speed to drop the water-phase solution into the oil-phase solution drop by drop, and stir after the dropping is completed to obtain a preliminary emulsion; (4) Homogenize the preliminary emulsion by a high-pressure microfluidizer under control pressure, cool, and discharge to obtain the ion-resistant liposomes.
[0015] As a preferred technical solution of the present application, the temperature of the control-temperature stirring in step (1) and step (2) is 65-70℃, and the time of the keeping warm is 20-30 min.
[0016] As a preferred technical solution of the present application, the speed of the control speed in step (3) is 2000-2200 r / min, and the time of the stirring is 20-30 min.
[0017] As a preferred technical solution of the present application, the pressure of the control pressure homogenization in step (4) is 230-250 MPa, and the number of times is 3; and the cooling is cooling to room temperature.
[0018] The application provides an application of the ion-resistant liposomes in cosmetics.
[0019] As a preferred technical solution of the present application, the cosmetics include but are not limited to skin care products and washing and caring products containing minerals.
[0020] The application has the following beneficial effects: (1) This application uses lecithin and polyglycerol-10 myristate in a specific ratio to synergistically enhance the interfacial stability of liposomes, effectively making the prepared liposome product have outstanding resistance to the destruction of liposome structure by metal ions, thus solving the technical pain point of traditional liposomes in the field being intolerant to ions.
[0021] (2) The liposomes prepared by this application have excellent antioxidant effects by synergistic effects of winged fruit oil, wicker seed extract and perilla fruit water from different dimensions such as reducing lipid peroxidation, lowering free radical levels and scavenging multiple free radicals.
[0022] (3) Prunus japonica seed extract can replenish moisture, Sal alopecuroides seed oil can lock in the replenished moisture and relieve dryness of the skin, winged fruit oil helps to improve the skin barrier function and repair dry, itchy or cracked skin, and roselle flower extract can promote the renewal of keratinocytes and assist winged fruit oil in making the skin barrier more stable. Therefore, the Prunus japonica seed extract, Sal alopecuroides seed oil, winged fruit oil and roselle flower extract used in this application can synergistically enhance each other, so that the liposomes prepared have excellent moisturizing effect. Detailed Implementation
[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0024] Information on the raw materials used in this application: Roselle flower extract: Product No.: 2673, purchased from Shaanxi Youerlv Biological Products Co., Ltd.; Pillile Fruit Water: Prepared using the following method: The dried pillia fruit is crushed and passed through a 20-mesh sieve to obtain pillia fruit crushed material. Five times the mass of the pillia fruit crushed material is added to deionized water and boiled. The mixture is then kept at a gentle boil for 2 hours. The mixture is filtered, and the filtrate is sterilized at 121℃ for 15 minutes. After cooling to room temperature, pillia fruit water is obtained. Prunus japonica seed extract: purchased from Shaanxi Xinyanghe Biotechnology Co., Ltd.; Narrow-winged Sal tree seed extract: purchased from Plant's Power; Winged fruit oil: purchased from Xi'an Jiatian Biotechnology Co., Ltd.; Lampwick seed extract: purchased from Lanzhou Waterles Biotechnology Co., Ltd.
[0025] Example 1 An ion-resistant liposome comprises the following raw materials in parts by weight: The aqueous phase active component is 75 parts by weight, the oil phase active component is 20 parts by weight, and the membrane material is 5 parts by weight.
[0026] The aqueous active component comprises active material, deionized water, and polyol in a mass ratio of 1:6:11, i.e., 4.2 parts by weight of active material, 25 parts by weight of deionized water, and 45.8 parts by weight of polyol. The active ingredient comprises hibiscus flower extract and perilla fruit water in a mass ratio of 12:1, i.e., 3.88 parts by weight of hibiscus flower extract and 0.32 parts by weight of perilla fruit water. The polyol comprises glycerol and 1,3-propanediol in a mass ratio of 8:1, i.e., 40.7 parts by weight of glycerol and 5.1 parts by weight of 1,3-propanediol. The active oil phase components include Prunus japonica seed extract, Salvia miltiorrhiza seed oil, samosa fruit oil, Ligustrum lucidum seed extract, squalane, and caprylic / capric triglycerides in a mass ratio of 1:4:1:3:18:20, namely, 0.43 parts by weight of Prunus japonica seed extract, 1.7 parts by weight of Salvia miltiorrhiza seed oil, 0.43 parts by weight of samosa fruit oil, 1.28 parts by weight of Ligustrum lucidum seed extract, 7.66 parts by weight of squalane, and 8.5 parts by weight of caprylic / capric triglycerides. The membrane material comprises lecithin and polyglycerol-10 myristate in a mass ratio of 8:1.5, i.e., 4.21 parts by weight of lecithin and 0.79 parts by weight of polyglycerol-10 myristate. The method for preparing the ion-resistant liposomes includes the following steps: (1) Mix the aqueous active components and stir evenly at 65°C, keep warm for 20 min to obtain an aqueous solution; (2) Mix the oil phase active component and the membrane material and stir evenly at 67.5℃, keep warm for 25 min to obtain the oil phase solution; (3) While stirring at a speed of 2000 r / min, add the aqueous phase solution dropwise into the oil phase solution. After the addition is complete, stir for another 30 min to obtain the primary emulsion. (4) The primary emulsion was homogenized three times under high pressure of 230 MPa using a high-pressure microfluidic apparatus, cooled to room temperature, and discharged to obtain ion-resistant liposomes.
[0027] Example 2 An ion-resistant liposome comprises the following raw materials in parts by weight: The aqueous phase active component is 70 parts by weight, the oil phase active component is 19.4 parts by weight, and the membrane material is 4.7 parts by weight.
[0028] The aqueous active component comprises active material, deionized water, and polyol in a mass ratio of 1:5.5:11.5, i.e., 3.9 parts by weight of active material, 21.4 parts by weight of deionized water, and 44.7 parts by weight of polyol. The active ingredient comprises hibiscus flower extract and perilla fruit water in a mass ratio of 13:1, i.e., 3.62 parts by weight of hibiscus flower extract and 0.28 parts by weight of perilla fruit water. The polyol comprises glycerol and 1,3-propanediol in a mass ratio of 6:1, i.e., 38.3 parts by weight of glycerol and 6.4 parts by weight of 1,3-propanediol. The active oil phase components include Prunus japonica seed extract, Salvia miltiorrhiza seed oil, winged fruit oil, Ligustrum lucidum seed extract, squalane, and caprylic / capric triglycerides in a mass ratio of 1.1:5:2:2.5:15:15, i.e., 0.53 parts by weight of Prunus japonica seed extract, 2.39 parts by weight of Salvia miltiorrhiza seed oil, 0.95 parts by weight of winged fruit oil, 19 parts by weight of Ligustrum lucidum seed extract, 7.17 parts by weight of squalane, and 7.17 parts by weight of caprylic / capric triglycerides. The membrane material comprises lecithin and polyglycerol-10 myristate in a mass ratio of 8.5:1.8, i.e., 3.88 parts by weight of lecithin and 0.82 parts by weight of polyglycerol-10 myristate. The method for preparing the ion-resistant liposomes includes the following steps: (1) Mix the aqueous active components and stir evenly at 70°C, keep warm for 25 min to obtain an aqueous solution; (2) Mix the oil phase active component and the membrane material and stir evenly at 65°C. Keep warm for 20 minutes to obtain the oil phase solution; (3) While stirring at a speed of 2100 r / min, add the aqueous phase solution dropwise into the oil phase solution. After the addition is complete, stir for another 20 min to obtain the primary emulsion. (4) The primary emulsion was homogenized three times under high pressure of 250 MPa using a high-pressure microfluidic apparatus, cooled to room temperature, and discharged to obtain ion-resistant liposomes.
[0029] Example 3 An ion-resistant liposome comprises the following raw materials in parts by weight: The aqueous phase active component is 72.5 parts by weight, the oil phase active component is 18.7 parts by weight, and the membrane material is 4.8 parts by weight.
[0030] The aqueous active component comprises active material, deionized water, and polyol in a mass ratio of 1:5.7:12, i.e., 3.88 parts by weight of active material, 22.1 parts by weight of deionized water, and 46.52 parts by weight of polyol. The active ingredient comprises hibiscus flower extract and pissula fruit water in a mass ratio of 12.5:1, i.e., 3.59 parts by weight of hibiscus flower extract and 0.29 parts by weight of pissula fruit water. The polyol comprises glycerol and 1,3-propanediol in a mass ratio of 7:1, i.e., 40.71 parts by weight of glycerol and 5.81 parts by weight of 1,3-propanediol. The active oil phase components include Prunus japonica seed extract, Salvia miltiorrhiza seed oil, winged fruit oil, Ligustrum lucidum seed extract, squalane, and caprylic / capric triglycerides in a mass ratio of 1.2:4.5:3:2:21:24, namely, 0.4 parts by weight of Prunus japonica seed extract, 1.51 parts by weight of Salvia miltiorrhiza seed oil, 1.01 parts by weight of winged fruit oil, 0.67 parts by weight of Ligustrum lucidum seed extract, 7.05 parts by weight of squalane, and 8.06 parts by weight of caprylic / capric triglycerides. The membrane material comprises lecithin and polyglycerol-10 myristate in a mass ratio of 9:2, i.e., 3.93 parts by weight of lecithin and 0.87 parts by weight of polyglycerol-10 myristate. The method for preparing the ion-resistant liposomes includes the following steps: (1) Mix the aqueous active components and stir evenly at 67.5℃, keep warm for 30 min to obtain an aqueous solution; (2) Mix the oil phase active component and the membrane material and stir evenly at 70°C. Keep warm for 30 minutes to obtain the oil phase solution; (3) While stirring at a speed of 2200 r / min, add the aqueous phase solution dropwise into the oil phase solution. After the addition is complete, stir for another 25 min to obtain the primary emulsion. (4) The primary emulsion was homogenized three times under high pressure of 240 MPa using a high-pressure microfluidic apparatus, cooled to room temperature, and discharged to obtain ion-resistant liposomes.
[0031] Comparative Example 1 Compared with Example 1, Comparative Example 1 did not add Prunus japonica seed extract. The missing weight was made up with Spatholobus suberectus seed oil, winged fruit oil and hibiscus flower extract in a mass ratio of 1.7:0.43:3.88. All other operation steps and parameters remained unchanged.
[0032] Comparative Example 2 Compared with Example 1, Comparative Example 2 did not add Spatholobus suberectus seed oil. The missing weight was made up with Prunus japonica seed extract, winged fruit oil and hibiscus flower extract in a mass ratio of 0.43:0.43:3.88. All other operation steps and parameters remained unchanged.
[0033] Comparative Example 3 Compared with Example 1, Comparative Example 3 did not add winged fruit oil. The missing weight was made up with Prunus japonica seed extract, Solanum tinctoria seed oil and Hibiscus rosa-sinensis flower extract in a mass ratio of 0.43:1.7:3.88. All other operation steps and parameters remained unchanged.
[0034] Comparative Example 4 Compared with Example 1, Comparative Example 4 did not add hibiscus flower extract. The missing weight was made up with Prunus japonica seed extract, Salix viminalis seed oil and winged fruit oil in a mass ratio of 0.43:1.7:0.43. All other operation steps and parameters remained unchanged.
[0035] Comparative Example 5 Compared with Example 1, Comparative Example 5 did not add winged fruit oil. The missing weight was made up with angelica seed extract and iris fruit water in a mass ratio of 1.28:0.32. All other operation steps and parameters remained unchanged.
[0036] Comparative Example 6 Compared with Example 1, Comparative Example 6 did not add semperflorens seed extract, and the missing weight was made up with winged fruit oil and semperflorens fruit water in a mass ratio of 0.43:0.32. All other operating steps and parameters remained unchanged.
[0037] Comparative Example 7 Compared with Example 1, Comparative Example 7 did not add Piper nigrum fruit water, and the missing weight was made up with winged fruit oil and calendula seed extract in a mass ratio of 0.43:1.28. All other operating steps and parameters remained unchanged.
[0038] Comparative Example 8 Compared with Example 1, Comparative Example 8 did not add polyglycerol-10 myristate, and the missing weight was made up with an equal mass of lecithin. All other operating steps and parameters remained unchanged.
[0039] Test Example 1 The ion-resistant liposomes prepared in Examples 1-3 and Comparative Example 8 were diluted 100 times with 0.01 mol / L phosphate buffer (pH=7.4). The basic particle size properties, zeta potential, and particle size changes under different metal ion environments of the ion-resistant liposomes were characterized using a nano-laser particle size analyzer. Each sample was measured 3 times and the average value was taken. The results are shown in Tables 1-2.
[0040] Table 1. Particle size fundamental properties and zeta potential Table 2 Ion Resistance As can be seen from the comparison of particle size basic properties in Table 1, the ion-resistant liposomes prepared in the embodiments of this application have a smaller average particle size and a lower dispersion index, indicating that they are more uniformly dispersed. The absolute value of the Zeta potential is higher, indicating that the liposome surface charge is stronger, the electrostatic repulsion is greater, and the system stability is better. As can be seen from the comparison of ion resistance performance in Table 2, the control group without polyglycerol-10 myristate showed a significant increase in particle size with increasing ion concentration in an environment containing sodium chloride, calcium chloride, and magnesium sulfate, resulting in obvious agglomeration. However, the ion-resistant liposomes prepared by adding polyglycerol-10 myristate in the present application maintained a stable particle size within the range of 90-107 nm under the same conditions, without significant agglomeration, demonstrating their excellent ion resistance performance. Obviously, the present invention, through the specific ratio of lecithin and polyglycerol-10 myristate, synergistically enhances the interfacial stability of liposomes, effectively resists the damage of metal ions to the liposome structure, and solves the technical pain point of traditional liposomes being intolerant to ions.
[0041] Test Example 2 The ion-resistant liposomes prepared in Examples 1-3 and Comparative Examples 5-7 were used to prepare a series of ion-resistant liposome suspensions with mass concentrations of 0.1, 0.2, 0.4, 0.8, 1.2, 1.6, and 2.0 mg / mL, respectively. 1 mL of the ion-resistant liposome suspension was accurately pipetted and mixed with 3 mL of freshly prepared DPPH ethanol solution (0.15 mmol / L). After incubation at room temperature in the dark for 30 min, the mixture was centrifuged at 4000 rpm for 30 min. The supernatant was collected and the absorbance was measured at 517 nm. The DPPH free radical scavenging rate of the ion-resistant liposomes was calculated using the following formula: Clearance rate (%) = [1 - (Ai - Aj) / A0] × 100%; in: Ai represents the absorbance of the sample (ion-resistant liposomes); Aj represents the absorbance of the control (ethanol instead of DPPH); A0 represents the absorbance value of the blank (ethanol is used instead of the sample). The results are shown in Table 3.
[0042] Table 3 DPPH free radical scavenging rate As can be seen from Table 2, within the detection range, the DPPH free radical scavenging ability of the liposomes prepared in the embodiments of this application is better than that of the liposomes prepared in the comparative example, indicating that the liposomes prepared under the formulation of this application have excellent in vitro antioxidant effects.
[0043] Test Example 3 (1) Trial samples: The same emulsion matrix was added to the ion-resistant liposomes prepared in Examples 1-3 and Comparative Examples 1-4 respectively to prepare trial samples (the amount of ion-resistant liposomes added was 5 wt% of the total mass of the trial samples). (2) Subjects: Subjects aged 20-45 years were randomly invited, regardless of gender, with 12 people in each group, for a total of 7 groups; Subjects must meet the following requirements: no history of skin sensitivity; no products used on the test site within 3 days before the test; a measurement area of 3cm×3cm was marked on the inner side of the subject's forearms, with one side as the test area and the other side as the control area; before the test, the subjects cleaned the inner side of their forearms and sat quietly for 20 minutes in a room with a temperature of 22℃ and a relative humidity of 50%RH, and did not drink water or beverages; (3) Method of use: Dissolve each group of test samples at 2 mg / cm³ 2 The amount of product was applied once, and the skin moisture content of the stratum corneum was measured using a skin moisture meter before and 120 minutes after application. Each area was measured three times in parallel and the average value was taken. The results are shown in Table 4.
[0044] Table 4. Changes in the moisture content (%) of the stratum corneum of the skin As can be seen from Table 1, the ion-resistant liposomes prepared in this application have outstanding moisturizing effects when used to prepare cosmetic emulsions.
[0045] In the description of this specification, the references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0046] The above description is merely an example and illustration of the concept of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described or use similar methods to replace them, as long as they do not deviate from the concept of the invention or exceed the scope defined in the claims, they should all fall within the protection scope of the present invention.
Claims
1. An ion-resistant liposome, characterized in that, Including the following parts by weight of raw materials: The aqueous phase active component is 70-75 parts by weight, the oil phase active component is 18.7-20 parts by weight, and the membrane material is 4.7-5 parts by weight.
2. The ion-resistant liposome according to claim 1, characterized in that, The aqueous active component comprises active material, deionized water, and polyol in a mass ratio of 1:5.5-6:11-12.
3. The ion-resistant liposome according to claim 2, characterized in that, The active ingredients consist of hibiscus flower extract and perilla fruit water in a mass ratio of 12-13:
1.
4. The ion-resistant liposome according to claim 2, characterized in that, The polyol comprises glycerol and 1,3-propanediol in a mass ratio of 6-8:
1.
5. The ion-resistant liposome according to claim 1, characterized in that, The oil phase active components include Prunus japonica seed extract, Salvia miltiorrhiza seed oil, Spatholobus suberectus seed oil, Ligusticum striatum seed extract, squalane, and caprylic / capric triglycerides in a mass ratio of 1-1.2:4-5:1-3:2-3:15-21:15-24.
6. The ion-resistant liposome according to claim 1, characterized in that, The membrane material includes at least one of lecithin and hydrogenated lecithin, and at least one of polyglycerol-10 lauryl ester and polyglycerol-10 myristate ester.
7. The ion-resistant liposome according to claim 6, characterized in that, The membrane material comprises lecithin and polyglycerol-10 myristate in a mass ratio of 8-9:1.5-2.
8. A method for preparing ion-resistant liposomes as described in any one of claims 1-7, characterized in that, Includes the following steps: (1) Mix the aqueous active components and stir evenly under controlled temperature, keep warm, and obtain an aqueous solution; (2) Mix the oil phase active component and the membrane material and stir evenly under controlled temperature, keep warm, and obtain an oil phase solution; (3) While stirring at a controlled speed, add the aqueous phase solution dropwise into the oil phase solution. After the addition is complete, stir again to obtain the primary emulsion. (4) The primary emulsion is homogenized under controlled pressure using a high-pressure microfluidic apparatus, cooled, and discharged to obtain ion-resistant liposomes.
9. The method for preparing ion-resistant liposomes according to claim 8, characterized in that, The temperature for temperature control and stirring in steps (1) and (2) is 65-70℃, and the holding time is 20-30min; the speed for speed control in step (3) is 2000-2200r / min; the stirring time is 20-30min; the pressure for pressure control and homogenization in step (4) is 230-250MPa, and the number of times is 3; the cooling is cooling to room temperature.
10. The application of the ion-resistant liposome as described in any one of claims 1-7 in cosmetics, wherein the cosmetics include mineral-containing skin care products and personal care products.