A high-throughput microsphere production system and method of production

Abstract

The application discloses a high-throughput microsphere production and preparation system, comprising a controller and a plurality of parallel microsphere preparation units, each of the microsphere preparation units comprising a valve assembly, a nozzle assembly, a temperature control module and a microfluidic module, the valve assembly and the temperature control module of each of the microsphere preparation units being signal-connected with the controller; a feeding port of the valve assembly is docked with an external feeding device, a discharging port of the valve assembly is docked with the nozzle assembly, the valve assembly is used for receiving a first fluid provided by the feeding device and controlling the output flow of the first fluid, and the nozzle assembly is used for spraying the first fluid output by the valve assembly; the high-throughput microsphere production and preparation system and the preparation method are used for overcoming the existing defects and can greatly improve the production capacity of microsphere preparation, have high stability and good microsphere size consistency.

Description

TECHNICAL FIELD

[0001] The present application relates to a high-throughput microsphere production system and a production method. BACKGROUND

[0002] In the prior art, microsphere preparation mainly relies on micro-injection pumps, traditional drop pill machines and other equipment. Among them, the micro-injection pump realizes the formation of droplets by controlling the constant low-speed flow of the oil phase and the water phase, but in order to avoid droplet merging or shape distortion, the flow rate of the oil phase needs to be strictly limited at a very low level (usually < 0.1 mL / min), which leads to low production efficiency of a single channel and makes it difficult to realize high-throughput production. At the same time, this technology requires very high flowability of the material, and can only handle systems with low viscosity (<1000 cp) and low powder content (<5%), and for viscous materials with high powder content (such as color powder accounting for 25-50% in cosmetics) and high viscosity (30000-100000 cp), problems such as flow channel blockage and irregular droplet breakage are prone to occur, and uniform droplets cannot be formed.

[0003] The traditional drop pill process can achieve a certain amount of production, but it relies on the gravity of the material itself to drop, and is extremely sensitive to changes in the viscosity of the material: when the material contains a high proportion of powder or active ingredients, the viscosity rises sharply, and "tail" and "satellite droplets" are easily formed at the nozzle, resulting in poor roundness of the microspheres (roundness < 0.8) and large particle size deviation (CV value > 20%). In addition, this process lacks a precise shear control mechanism, and droplets are easily affected by gravity during the solidification process, forming irregular particles such as flat and oval particles, which requires an additional screening process, further reducing production efficiency.

[0004] For oily microspheres, the limitations of existing technologies are even more prominent. Oily systems usually contain ingredients such as wax and oil, which are in a high-viscosity state at room temperature and have significant viscosity fluctuations with temperature changes. Traditional equipment lacks an integrated temperature control and shear coordination mechanism: if the temperature is not controlled properly, the material is prone to solidification and blockage at the nozzle; if the shear force is insufficient, high-viscosity droplets cannot quickly contract into spheres, resulting in chaotic microsphere morphology. At the same time, existing technologies cannot achieve multi-channel parallel production - single-channel efficiency is low, and when multiple channels are used in parallel, the pressure and temperature of each channel are inconsistent, leading to a sharp decline in microsphere uniformity, ultimately making it impossible to achieve large-scale production.

[0005] In summary, the existing technology cannot achieve high-throughput and high-regularity microsphere production due to the following core defects: first, the flowability of the material is strictly required, which cannot adapt to functional systems with high powder content and high viscosity; second, there is a lack of precise flow rate, temperature, and shear force coordination mechanism, and the morphology and uniformity of the microspheres cannot be guaranteed during high-speed production; third, the equipment is dispersed, and it is difficult to achieve stable coordination of multiple channels in parallel, and the throughput is limited. SUMMARY

[0006] The present application aims to overcome the existing defects and provide a high-throughput microsphere production preparation system and a preparation method, which can greatly improve the production capacity of microsphere preparation and has the effects of high stability and good microsphere size consistency.

[0007] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a high-throughput microsphere production preparation system, comprising a controller and a plurality of parallel microsphere preparation units, each microsphere preparation unit comprising a valve assembly, a nozzle assembly, a temperature control module and a microfluidic module, the valve assembly and the temperature control module of each microsphere preparation unit being signal connected with the controller;

[0008] The feed inlet of the valve assembly is connected to an external feed device, the discharge outlet of the valve assembly is connected to the nozzle assembly, the valve assembly is used to receive the first fluid provided by the feed device and control the output flow of the first fluid, and the nozzle assembly is used to spray the first fluid output by the valve assembly;

[0009] The temperature control module is installed at the bottom of the valve assembly and its heating working surface is attached to the outer wall of the nozzle assembly, which is used to heat the first fluid before it is sprayed into the nozzle assembly;

[0010] The microfluidic module is installed at the bottom of the temperature control module and its feed inlet is directly opposite the discharge outlet of the nozzle assembly, and its liquid inlet is connected to an external liquid supply device, the microfluidic module is used to receive the second fluid provided by the liquid supply device, and the second fluid flowing in the internal chamber of the microfluidic module is used to shear and wrap the first fluid sprayed by the nozzle assembly to form microspheres.

[0011] Preferably, the valve assembly is a piezoelectric valve, the piezoelectric valve is provided with a piezoelectric ceramic, a displacement amplification mechanism, a striker and a first fluid channel, the first fluid channel connects the feed inlet and the striker working area of the piezoelectric valve, the first fluid channel is used to transport the first fluid to the striker working area, the striker working area is connected to the nozzle assembly through the discharge outlet of the piezoelectric valve, and the piezoelectric ceramic drives the striker to impact the fluid in the working area at high frequency through the displacement amplification mechanism.

[0012] Preferably, the piezoelectric valve has an adjusting knob, the adjusting knob is used to adjust the gap between the striker and the nozzle assembly, the inner wall shape of the nozzle assembly is matched with the head shape of the striker, and when the striker is in the initial position, the head of the striker is attached to the inner wall of the nozzle assembly to form a linear seal or a face seal.

[0013] Preferably, it further comprises a piezoelectric valve controller, the piezoelectric valve controller is electrically connected with the piezoelectric valve, and is used to adjust the rising time, the falling time, the initial impact speed, the impact frequency and the impact amplitude of the striker.

[0014] Preferably, the valve assembly is a proportional regulating valve, the outlet of the valve assembly is a switch nozzle of the proportional regulating valve, the proportional regulating valve has a first fluid channel connecting the inlet and the switch nozzle, the first fluid channel is used to transport the first fluid to the switch nozzle of the proportional regulating valve, and the switch nozzle is connected to the nozzle assembly.

[0015] Preferably, a proportional valve controller is further included, which is electrically connected to the proportional regulating valve, used to adjust the switch time of the switch nozzle and the air pressure in the valve body, thereby controlling the output flow of the first fluid.

[0016] Preferably, the inlet of the valve assembly is provided with a pressure device for providing positive pressure; and an elastic sealing pad is arranged between the nozzle assembly and the outlet of the valve assembly.

[0017] Preferably, the valve assembly has an air inlet connected to the first fluid channel, and an external air supply device supplies air to the valve assembly through the air inlet to increase the flowability of the first fluid.

[0018] Preferably, the microfluid module has a microfluid channel cavity, a shaping cavity and a guide-out cavity, which are sequentially and continuously connected from top to bottom, and the central axes of the microfluid channel cavity, the shaping cavity and the guide-out cavity are coincident with the central axis of the nozzle assembly.

[0019] The microfluid channel cavity and the guide-out cavity are both cylindrical, and the pore diameter of the microfluid channel cavity is larger than the pore diameter of the outlet end of the nozzle assembly.

[0020] The shaping cavity is trumpet-shaped, and the small-diameter end and the large-diameter end of the shaping cavity are respectively connected to the microfluid channel cavity and the guide-out cavity.

[0021] Preferably, the microfluid module further has an annular channel cavity.

[0022] The sidewall of the microfluid module has a liquid flow guide for guiding the second fluid from an external liquid supply device into the annular channel cavity.

[0023] The central axis of the annular channel cavity is coincident with the central axis of the nozzle assembly.

[0024] The nozzle assembly and the microfluid channel cavity have a gap therebetween, and the annular channel cavity is connected to the gap between the microfluid channel cavity and the nozzle assembly.

[0025] A preparation method based on the high-throughput microsphere production preparation system, comprising the following steps:

[0026] Step S1, water phase preparation and oil phase preparation are performed.

[0027] Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation;

[0028] The oil phase flows into the internal cavity of the microfluidic module of the microsphere preparation unit through the valve assembly and the nozzle assembly of the microsphere preparation unit, the water phase flows into the internal cavity of the microfluidic module from another direction, and the oil phase droplets sprayed by the nozzle assembly are subjected to shearing and wrapping treatment to form microspheres.

[0029] The step S1, the water phase preparation and the oil phase preparation include:

[0030] Step S11, the water and thickening agent are heated, stirred and uniformly dispersed, and after cooling, the humectant, preservative, efficacy aid, neutralizing agent are added to prepare the water phase;

[0031] Step S12, after the oil curing agent and non-silicon oil are heated and completely dissolved, the pretreated oil gel agent is added, uniformly dispersed after homogenization, the pre-dispersed color paste is added, and after homogenization and dispersion, the remaining makeup aid, active aid, fragrance component and preservative are added, and the oil phase is obtained after homogenization and mixing.

[0032] Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation; including:

[0033] The piezoelectric valve is used for microsphere preparation; the valve assembly of the microsphere preparation unit is a piezoelectric valve, the piezoelectric valve has a striker and a first fluid channel, the first fluid channel is used for transporting the oil phase to the striker working area, and the striker working area is communicated with the nozzle assembly;

[0034] Step S21, the oil phase is introduced into the piezoelectric valve, the oil phase is transported through the first fluid channel, and after constant temperature heating of the temperature control module, the oil phase is impacted by the striker of the piezoelectric valve into the nozzle assembly, the oil phase is sprayed by the nozzle assembly to form uniform droplets and enters the microflow cavity, the water phase in the annular channel cavity introduced by the liquid flow guide is met with the oil phase droplets through the gap between the nozzle assembly and the microflow cavity, realizing all-around vertical shearing of the oil phase droplets, under the action of all-around shearing force of the water phase, the oil phase droplets quickly shrink to form a highly regular spherical morphology, and then enter the forming cavity through the microflow cavity, further stabilize the microsphere morphology, and finally the microspheres are collected by the collection device connected to the outlet cavity.

[0035] Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation; including:

[0036] The microsphere preparation is performed using a proportional regulating valve; the valve assembly of the microsphere preparation unit is a proportional regulating valve, which has a first fluid channel for conveying the oil phase to the switch nozzle of the proportional regulating valve, and the switch nozzle is communicated with the nozzle assembly;

[0037] In step S21, the oil phase is introduced into the proportional regulating valve, the oil phase is conveyed through the first fluid channel, heated by the constant temperature module, and then enters the nozzle assembly through the high-frequency impact of the switch nozzle of the proportional regulating valve, the oil phase is sprayed out of the nozzle assembly to form uniform droplets and enters the microfluidic cavity, the water phase in the annular channel cavity introduced by the liquid flow guide channel meets the oil phase droplets through the gap between the nozzle assembly and the microfluidic cavity, and the oil phase droplets are subjected to all-around vertical shearing, under the action of the all-around shearing force of the water phase, the oil phase droplets rapidly shrink to form a highly regular spherical morphology, and then enter the forming cavity through the microfluidic cavity to further stabilize the microsphere morphology, and finally the microspheres are collected by the collection device connected to the outlet cavity.

[0038] Further comprising: adjusting the shape of the microspheres by selecting different nozzle assemblies.

[0039] Further comprising: adjusting the shape of the microspheres by adjusting the drop time of the striker in the piezoelectric valve;

[0040] Under the condition that the movement amplitude and frequency of the striker in the piezoelectric valve are constant, the size of the microspheres is adjusted by adjusting the pressure of the feed port; and

[0041] Under the condition that the pressure of the feed port is constant, the ejection frequency of the oil phase droplets is adjusted by adjusting the movement frequency of the striker in the piezoelectric valve.

[0042] Further comprising: adjusting the distance between the microspheres by adjusting the flow rate of the oil phase at the feed port or by adjusting the flow rate of the liquid phase at the inlet of the microfluidic module, and further adjusting the ratio of the microspheres to the liquid when the microspheres are collected.

[0043] In step S11, the water is one or more of deionized water, birch juice, rose water, aloe leaf water, fermented cell lysate filtrate, yeast cell lysate filtrate, yeast fermentation product, lactobacillus fermentation product, diploid yeast fermentation product filtrate, musk rose water, galactose yeast-like bacteria fermentation product filtrate, and the amount is 50%-99.5%;

[0044] The thickening agent is one or more of carbomer, xanthan gum, welan gum, cellulose gum, polyacrylic acid, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / decyl vinyl ester crosspolymer, acryloyldimethyltauramide / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyacryloyldimethyl sodium taurate, sodium hyaluronate, in an amount of 0.01-5%;

[0045] The humectant is one or more of glycerin, diglycerin, polyglyceryl-3, polyglyceryl-10, propylene glycol, butylene glycol, trehalose, tremella fuciformis polysaccharide;

[0046] The preservative is one or more of phenoxyethanol, pentylene glycol, hexylene glycol, p-hydroxyacetophenone, ethylhexylglycerin, caprylyl oxyhydroxamic acid, caprylyl glycol, potassium sorbate, hydroxybenzoic acid ester with a preservative effect;

[0047] The efficacy aid is one or more of sodium hyaluronate, acetylated sodium hyaluronate, acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, oat kernel extract, collagen, hydrolyzed protein, beta-glucan, panthenol, allantoin;

[0048] The neutralizing agent is one or more of tromethamine, sodium hydroxide, arginine, aminomethyl propanol, sodium citrate;

[0049] The heating temperature is 60-85℃;

[0050] The stirring speed is 300-8000rpm, and the stirring time is 10-60min;

[0051] After stirring, the temperature is lowered to 35-60℃.

[0052] In step S12, the oil curing agent is one or more of synthetic wax, paraffin wax, vegetable wax, microcrystalline wax, beeswax, dextrin palmitate, dextrin myristate, and HDI / trihydroxymethyl hexyl lactone crosspolymer, in an amount of 0.3-10%;

[0053] The non-silicon oil and fat is one or more of plant oil and fat, synthetic oil ester, or alkane oil and fat, in an amount of 20-50%;

[0054] The heating temperature is 50-110℃;

[0055] The pretreated oil gel agent is one or more of distearyldimethyl ammonium lithium montmorillonite, castor oil / IPDI copolymer, in an amount of 1-25%;

[0056] The color paste is obtained by uniformly mixing or grinding the color powder with the dispersant and oil and fat, in an amount of 25-60%.

[0057] The cosmetic effect aid is one or more of synthetic fluorphlogopite, bismuth oxychloride, mica, silica, perlite, and gemstone powder;

[0058] The active aid is one or more of tocopherol, bisabolol, and spilanthes extract;

[0059] The fragrance component is one or more of a perfume or an essential oil.

[0060] The thickening agent is one or more of carbomer or acrylates / ethylhexyldecyl acrylate crosspolymer, and is used in an amount of 0.02-0.5%.

[0061] Compared with the prior art, the high-throughput microsphere production preparation system and the preparation method have the beneficial effects that the valve assembly, the nozzle assembly, the temperature control module, and the microfluidic module are integrated together, the valve assembly, the temperature control module, and the gas supply and material supply device are centrally controlled by the same controller, the overall device has low complexity and operation and maintenance cost, high-powder-content and high-viscosity material bodies can be produced at high speed and high uniformity by precisely controlling the material output by the valve assembly and by the constant temperature guarantee of the temperature control module. The production capacity of the microsphere preparation can be greatly improved, and the microspheres have high stability and good size consistency. BRIEF DESCRIPTION OF DRAWINGS

[0062] The accompanying drawings are included to provide a further understanding of the application, and constitute a part of this specification, illustrate embodiments of the application, and are included to explain the application, and do not limit the application. In the drawings:

[0063] Figure 1 It is a schematic diagram of the high-throughput microsphere production preparation system of the application;

[0064] Figure 2 It is a sectional view of the high-throughput microsphere production preparation system of the application;

[0065] Figure 3 It is an isometric view of the microsphere preparation unit of embodiment one of the application;

[0066] Figure 4 It is a front view of the microsphere preparation unit of embodiment one of the application;

[0067] Figure 5 It is an isometric view of the microsphere preparation unit of embodiment two of the application;

[0068] Figure 6 It is a front view of the microsphere preparation unit of embodiment two of the application;

[0069] Figure 7 It is a flowchart of the high-throughput microsphere production preparation method of the application.

[0070] In the diagram: 1. Piezoelectric valve; 11. Air inlet; 12. Adjustment knob; 13. Feed inlet; 14. First fluid channel; 2. Nozzle assembly; 3. Temperature control module; 31. Placement slot; 4. Microfluidic module; 41. Microchannel cavity; 42. Forming cavity; 43. Outlet cavity; 44. Annular channel cavity; 45. Liquid flow guide channel; 46. Positioning slot; 5. Elastic sealing gasket; 6. Proportional regulating valve. Detailed Implementation

[0071] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0072] Example 1

[0073] like Figures 1-4 As shown, a high-throughput microsphere production system includes a controller and several microsphere preparation units arranged in parallel. Each microsphere preparation unit includes a valve assembly, a nozzle assembly 2, a temperature control module 3, and a microfluidic module 4. The valve assembly and temperature control module 3 of each microsphere preparation unit are signal-connected to the controller. The inlet of the valve assembly is connected to an external feeding device, and the outlet of the valve assembly is connected to the nozzle assembly 2. The valve assembly is used to receive a first fluid provided by the feeding device and control the output flow rate of the first fluid. The nozzle assembly 2 is used to spray the first fluid output by the valve assembly. The temperature control module 3 is installed at the bottom of the valve assembly, and its heating working surface is attached to the outer wall of the nozzle assembly 2. It is used to heat the first fluid entering the nozzle assembly 2 before spraying. The microfluidic module 4 is installed at the bottom of the temperature control module 3, and its inlet is directly opposite the outlet of the nozzle assembly 2. Its liquid inlet is connected to an external liquid supply device. The microfluidic module 4 is used to receive a second fluid provided by the liquid supply device and uses the second fluid flowing in its internal chamber to shear and encapsulate the first fluid sprayed by the nozzle assembly 2 to form microspheres.

[0074] Specifically, the valve assembly is a piezoelectric valve 1, which has an inlet 13 and an outlet (not shown in the figure). The piezoelectric valve 1 is equipped with a piezoelectric ceramic (not shown in the figure), a displacement amplification mechanism (not shown in the figure), an impact pin (not shown in the figure), and a first fluid channel 14. The first fluid channel 14 connects the inlet 13 of the piezoelectric valve 1 and the working area of ​​the impact pin, and is used to transport the first fluid to the working area of ​​the impact pin. The working area of ​​the impact pin is connected to the nozzle assembly 2 through the outlet of the piezoelectric valve 1. The piezoelectric ceramic drives the impact pin to impact the fluid in the working area at a high frequency through the displacement amplification mechanism.

[0075] Specifically, the piezoelectric ceramic generates micro-deformation under the action of voltage, and the displacement amplification mechanism can increase the stroke. The driving mechanism composed of the piezoelectric ceramic and the displacement amplification mechanism can drive the striker to achieve high-frequency impact through high-frequency voltage change. The piezoelectric valve 1 opens the valve nozzle to spray droplets instantaneously, and the striker resets to close the flow channel after power-off.

[0076] Specifically, the piezoelectric valve 1 has an adjusting knob 12 for adjusting the gap between the striker and the nozzle assembly 2. The inner wall of the nozzle assembly 2 is shaped to match the shape of the head of the striker. When the striker is in the initial position, the head of the striker fits the inner wall of the nozzle assembly 2 to form a linear seal or face seal. At this time, the flow channel is temporarily closed, and the first fluid in the piezoelectric valve 1 cannot leak out, so as to ensure that the first fluid can form a ball independently after each spraying.

[0077] Specifically, the piezoelectric valve 1 has an air inlet 11 connected to the first fluid channel 14. The external air supply device supplies air to the piezoelectric valve 1 through the air inlet 11 to increase the flowability of the first fluid.

[0078] Specifically, the piezoelectric valve 1 has a feed inlet 13 connected to a feed pipeline. The feed pipeline is provided with a pressure device for providing positive pressure to push the material (i.e. the first fluid) at the feed inlet into the piezoelectric valve body. Controlling the pressure of the feed pipeline can ensure smooth transmission of the first fluid in the flow channel and reduce the risk of nozzle assembly 2 blockage.

[0079] Specifically, the piezoelectric valve controller is electrically connected to the piezoelectric valve 1 and is used to adjust the valve opening time, the rising time and the falling time of the striker, the initial impact speed, the impact frequency and the amplitude.

[0080] Specifically, an elastic sealing pad 5 is arranged between the nozzle assembly 2 and the discharge port of the piezoelectric valve 1. The elastic sealing pad 5 has a certain deformation recovery ability and is particularly suitable for low-flow spraying scenarios (<0.1 mL / min). It provides effective sealing compensation during spraying, stabilizes the internal pressure, prevents droplet breakage or deviation, and thus guarantees the integrity of the microsphere shape.

[0081] Specifically, the microfluidic module 4 has a microfluid channel cavity 41, a forming cavity 42 and a guide cavity 43 arranged in sequence from top to bottom, and the central axes of the microfluid channel cavity 41, the forming cavity 42 and the guide cavity 43 coincide with the central axis of the nozzle assembly 2. The microfluid channel cavity 41 and the guide cavity 43 are both cylindrical, the forming cavity 42 is trumpet-shaped, and the small-diameter end and the large-diameter end of the forming cavity 42 are respectively connected to the microfluid channel cavity 41 and the guide cavity 43.

[0082] Specifically, the microfluid module 4 further has an annular channel cavity 44, the sidewall of the microfluid module 4 has a liquid flow guide 45 for guiding the second fluid from an external liquid supply device into the annular channel cavity 44, the central axis of the annular channel cavity 44 coincides with the central axis of the nozzle assembly 2, and the nozzle assembly 2 and the microfluid channel cavity 41 have a gap therebetween, and the annular channel cavity 44 communicates with the gap between the microfluid channel cavity 41 and the nozzle assembly 2.

[0083] Specifically, the pore size of the microfluid channel cavity 41 is required to be larger than the pore size of the outlet end of the nozzle assembly 2, and the pore size of the outlet end of the nozzle assembly 2 is set according to the size of the liquid droplets required to be sprayed in the microsphere production process, and the shape of the outlet end of the nozzle assembly 2 is set according to the shape of the liquid droplets required to be sprayed in the microsphere production process.

[0084] Preferably, the pore size of the microfluid channel cavity 41 ranges from 110 to 2000 μm, and the pore size of the outlet end of the nozzle assembly 2 ranges from 100 to 1000 μm.

[0085] Specifically, the temperature control module 3 has a placement groove 31 matched with the outer wall of the nozzle assembly 2, the outlet of the valve assembly and the nozzle assembly 2 are located in the placement groove 31, the temperature control module 3 has a heating element for heating the sidewall of the placement groove 31 and a temperature measuring element for measuring the temperature of the sidewall of the placement groove 31, and the heating element and the temperature measuring element are commonly electrically connected to a controller.

[0086] Preferably, the controller commonly electrically connected to the heating element and the temperature measuring element is integrated with the piezoelectric valve controller. Further, the piezoelectric valve 1, the temperature control module 3, and the liquid supply device and the gas supply device are collectively controlled by the same controller.

[0087] Further, the temperature control module 3 can control the working temperature in the range of 20 to 100℃, so as to adapt to the temperature environment requirements of different types of raw materials and ensure the viscosity stability and the quality of the microspheres.

[0088] In the embodiment, the piezoelectric valve 1, the nozzle assembly 2, the temperature control module 3, and the microfluid module 4 are integrated together, and the overall device has low complexity and low operation and maintenance cost. When the microspheres are manufactured, the first fluid is introduced into the piezoelectric valve 1 through the inlet 13 of the piezoelectric valve 1, the first fluid is transported through the first fluid channel 14, and after being heated by the temperature control module 3, the first fluid is impacted by the high-frequency impact of the striker into the nozzle assembly 2, and the first fluid in the nozzle assembly 2 is sprayed at high speed to form liquid droplets. Since the outlet of the nozzle assembly 2 is directly opposite the inlet of the microfluid module 4, the liquid droplets sprayed by the nozzle assembly 2 can accurately enter the microfluid module 4 in large quantities, thereby reducing the waste of raw materials. After the liquid droplets are sprayed by the nozzle assembly 2, the liquid droplets are processed in the related cavities in the microfluid module 4 to complete the manufacturing of the microspheres.

[0089] Specifically, in the above implementation process, based on the high-precision jetting characteristics of the piezoelectric valve 1 and the constant temperature control of the temperature control module 3, the consistency and stability of the droplets sprayed by the nozzle assembly 2 are high, and the piezoelectric valve 1 can realize stable operation for a long time, thereby ensuring the continuous production of microspheres.

[0090] In the present embodiment, the first fluid is sprayed by the nozzle assembly 2 to form uniform droplets, and when the droplets enter the microfluid channel cavity 41, they are constrained by the inner wall of the microfluid channel cavity 41, deform under the balance of shear force and surface tension, and become microspheres of the same diameter. Then the formed microspheres enter the forming cavity 42, which is in a horn-shaped structure, can avoid fluid separation, maintain laminar flow state, and play a role in speed reduction. Finally, the microspheres enter the lead-out cavity 43, and the collection of the microspheres is realized by connecting the lead-out cavity 43 to the collection device.

[0091] In the above preferred solution, when the droplets formed by the first fluid enter the microfluid channel cavity 41, the second fluid introduced by the liquid flow guide channel 45 into the annular passage cavity 44 meets the droplets formed by the first fluid through the gap between the nozzle assembly 2 and the microfluid channel cavity 41, realizing all-around vertical shearing of the droplets formed by the first fluid. Under the action of the all-around shearing force of the second fluid, the droplets quickly contract to form a highly regular spherical morphology, and then enter the forming cavity 42 through the microfluid channel cavity 41 to further stabilize the microsphere morphology. Finally, the microspheres are collected by the collection device connected to the lead-out cavity 43.

[0092] In the above implementation process, in order to facilitate the introduction of the second fluid, a connecting pipe (not marked in the figure) communicating with the liquid flow guide channel 45 is installed on the side wall of the microfluid module 4, and in order to facilitate the positioning of the connecting pipe, a plurality of positioning grooves 46 are arranged at intervals in the peripheral area of the microfluid module 4.

[0093] In a preferred embodiment, the temperature control module 3 has a foolproof structure with the piezoelectric valve 1 and the microfluid module 4.

[0094] Specifically, the specific performance of the foolproof structure can adopt the form of a positioning column combined with a positioning hole or a positioning groove combined with a positioning protrusion. In the present preferred solution, through the design of the foolproof mechanism, manual calibration is not required during assembly, which can ensure the stable coaxial alignment of the outlet of the nozzle assembly 2 and the inlet of the microfluid module 4, thereby ensuring the consistency and repeatability of the jetting path, and improving the overall operation convenience and reliability of the system.

[0095] In another optional embodiment, the microfluid module 4 is made of transparent material.

[0096] Specifically, the microfluidic module 4 can be made of a high-transparency high-molecular resin material, which has excellent optical visibility and helps the operator to observe the generation and fusion state of the microdroplets in real time during the preparation process, thereby improving the visualization level of process control.

[0097] The following takes the foundation microspheres as an example to describe the complete process from the piezoelectric valve 1 to the shearing division and stable output of the microfluidic module 4, highlighting the technical advantages and process details of the device.

[0098] The foundation phase raw material (i.e., the first fluid, usually a high-viscosity cosmetic raw material) is input into the first fluid channel 14 of the piezoelectric valve 1 through the feed port 13 of the piezoelectric valve 1, and the essence phase raw material (i.e., the second fluid, which has a lower viscosity than the first fluid) is input through the liquid flow guide 45. The feed port 13 provides a supply gas pressure of 0.1 to 0.5 MPa to enhance the flowability of the foundation phase and ensure smooth transmission in the flow channel.

[0099] Before the system starts, the temperature control module accurately maintains the working temperature at 25±0.5°C through the built-in heating element and temperature sensor, optimizes the rheological properties of the raw materials and the droplet forming conditions, and prevents changes in physical and chemical properties caused by temperature fluctuations. The piezoelectric valve controller sets the impact frequency (10 Hz~1500 Hz) and amplitude of the striker according to the process requirements, ensuring that the droplet injection frequency and droplet size are accurately controlled. Under the drive of the electric pulse signal, the piezoelectric ceramic of the piezoelectric valve 1 produces high-frequency vibration and drives the striker to perform rapid reciprocating motion, cutting the foundation phase raw material into uniform and small droplets and then spraying them out from the nozzle assembly 2. The spray port is precisely aligned with the microfluid channel cavity inlet of the microfluidic module through the foolproof structure, ensuring that the droplets accurately enter the microfluid channel cavity 41 and avoiding deviation or raw material waste.

[0100] After entering the microfluidic module, the foundation phase droplets meet the essence phase fluid input through the liquid flow guide 45 in the microfluid channel cavity. Based on the structural design of the flow channel, the essence phase applies omnidirectional shear force to the droplets in the form of vertical shear flow, quickly washing away the droplets while applying shear force to the droplets, making them present a highly regular spherical morphology. The microspheres then enter the forming cavity 42 through the microfluid channel cavity 41 for further stabilization of their morphology, and are continuously output to the collection device through the outlet cavity 43.

[0101] The entire process is monitored in real time through the transparent microfluidic module 4, and the operator can directly observe the formation state, size distribution, and flow trajectory of the droplets, and adjust the foundation phase injection frequency, essence phase flow rate, or supply gas pressure in real time according to the flow indicator and process feedback data. For example, if the microsphere particle size is too large, the valve opening time can be shortened to reduce the droplet size. If the morphology is irregular, the supply gas pressure or working temperature can be optimized to improve the fluid stability.

[0102] The high-throughput microsphere production and preparation system provided by the embodiment realizes high-precision injection of the foundation phase, shear forming in the micro-channel cavity 41, constant temperature protection of the temperature control module 3, and flexible adjustment of flow regulation, thereby realizing high consistency and stability of the microspheres. The operator replaces different nozzle assemblies 2 or adjusts the knobs 12 to adapt to raw material systems with different viscosities and rheological properties, and the automatic control system supports long-time continuous operation, thereby significantly reducing manual intervention and production cost. The foolproof structure and intelligent control of the device further ensure the reliability and repeatability of the process, thereby providing an efficient and reliable technical solution for the fields of drug controlled release, cosmetic microencapsulation, and biological material preparation.

[0103] In the embodiment, the high-throughput microsphere production and preparation system has a plurality of microsphere preparation units, which can work independently or simultaneously. Whether the microsphere preparation units work simultaneously is set according to the yield requirement of the microspheres.

[0104] Preferably, the microfluidic modules 4 of the plurality of microsphere preparation units can be connected as a whole. In this way, the device structure is more compact.

[0105] Correspondingly, the embodiment also provides a preparation method based on the high-throughput microsphere production and preparation system. As shown in Figure 7 The preparation method based on the high-throughput microsphere production and preparation system includes the following steps:

[0106] Step S1, water phase preparation and oil phase preparation are performed;

[0107] Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation;

[0108] Specifically, the oil phase flows into the internal cavity of the microfluidic module 4 of the microsphere preparation unit via the valve assembly and the nozzle assembly 2 of the microsphere preparation unit, the water phase flows into the internal cavity of the microfluidic module 4 from another direction, and the oil phase droplets sprayed by the nozzle assembly 2 are subjected to shearing and wrapping treatment to form microspheres.

[0109] Specifically, step S1, water phase preparation and oil phase preparation include:

[0110] Step S11, the water and the thickening agent are heated, stirred and dispersed uniformly, and after cooling, the humectant, the preservative, the efficacy aid, the neutralizing agent are added to prepare the water phase;

[0111] Step S12, the oil curing agent and the non-silicon oil are heated and dissolved completely, then the pretreated oil gel agent is added, and after homogeneous dispersion, the pre-dispersed color paste is added, and after homogeneous dispersion again, the remaining makeup effect aid, active aid, fragrance component and preservative are added, and homogeneous mixing is performed to obtain the oil phase.

[0112] Step S2 involves conveying the aqueous and oil phases to several parallel-connected microsphere preparation units for microsphere preparation; including:

[0113] Microspheres are prepared using a piezoelectric valve; the valve assembly of the microsphere preparation unit is a piezoelectric valve 1, which has a striking pin and a first fluid channel 14. The first fluid channel 14 is used to transport the oil phase to the working area of ​​the striking pin, and the working area of ​​the striking pin is connected to the nozzle assembly 2.

[0114] In step S21, the oil phase is introduced into the piezoelectric valve 1. The oil phase is transported through the first fluid channel 14 and heated at a constant temperature by the temperature control module 3. Then, it is impacted by the high-frequency impact of the striking pin of the piezoelectric valve 1 into the nozzle assembly 2. The oil phase is sprayed out through the nozzle assembly 2 to form uniform droplets and enters the microfluidic cavity 41. The water phase, which is introduced into the annular channel cavity 44 by the liquid flow guide channel 45, meets the oil phase droplets through the gap between the nozzle assembly 2 and the microfluidic cavity 41, realizing the all-round vertical shearing of the oil phase droplets. Under the all-round shearing force of the water phase, the oil phase droplets rapidly shrink to form a highly regular spherical shape. Then, they enter the forming cavity 42 through the microfluidic cavity 41 to further stabilize the microsphere morphology. Finally, the microspheres are collected by the collection device connected to the outlet cavity 43.

[0115] In step S11, the water is one or more of the following: deionized water, birch sap, rose water, aloe vera leaf water, fermentation lysate filtrate, yeast lysate filtrate, yeast fermentation product, lactobacillus fermentation product, Bifida ferment filtrate, Rosa damascena flower water, and galactosomalidase fermentation product filtrate, in an amount of 50%-99.5%.

[0116] The thickener is one or more of the following: carbomer, xanthan gum, Brunei gum, cellulose gum, polyacrylic acid, acrylate / C10-30 alkyl acrylate crosspolymer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylate / vinyl isodecanoate crosspolymer, ammonium acryloyl dimethyl taurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, sodium polyacryloyl dimethyl taurate, and sodium hyaluronate, in an amount of 0.01-5%.

[0117] The moisturizer is one or more of glycerin, diglycerin, polyglycerol-3, polyglycerol-10, propylene glycol, butylene glycol, trehalose, and tremella polysaccharide;

[0118] The preservative is one or more of the following: phenoxyethanol, pentylene glycol, hexanediol, p-hydroxyacetophenone, ethylhexylglycerin, capryloyl hydroxamic acid, caprylyl glycol, potassium sorbate, and methylparaben.

[0119] The efficacy aid is one or more of sodium hyaluronate, sodium acetyl hyaluronate, acetyl hexapeptide-8, dipeptide diaminobutyroyl hydrazide dipropionic acid, oat kernel extract, collagen, hydrolyzed protein, beta-glucan, panthenol, allantoin;

[0120] The neutralizing agent is one or more of tromethamine, sodium hydroxide, arginine, aminomethyl propanol, sodium citrate;

[0121] The heating temperature is 60-85°C;

[0122] The stirring speed is 300-8000 rpm, and the stirring time is 10-60 min;

[0123] After stirring, the temperature is lowered to 35-60°C.

[0124] In step S12, the oil curing agent is one or more of synthetic wax, paraffin wax, vegetable wax, microcrystalline wax, beeswax, dextrin palmitate, dextrin myristate, and HDI / trimethylol hexyl lactone cross-linked polymer, and the amount used is 0.3-10%;

[0125] The non-silicon oil and fat is one or more of plant oil and fat, synthetic oil ester, or alkane oil and fat, and the amount used is 20-50%;

[0126] The heating temperature is 50-110°C;

[0127] The pretreated oil gel agent is one or more of lithium montmorillonite disteridimethylammonium, castor oil / IPDI copolymer, and the amount used is 1-25%;

[0128] The color paste is obtained by uniformly mixing or grinding the color powder with the dispersing agent and the oil and fat, and the amount used is 25-60%;

[0129] The cosmetic effect aid is one or more of synthetic fluorphlogopite, bismuth oxychloride, mica, silica, perlite, and gemstone powder;

[0130] The active aid is one or more of tocopherol, bisabolol, and spilanthes extract;

[0131] The fragrance component is one or more of fragrance or essential oil.

[0132] The thickening agent is one or more of carbomer or acrylate / isodecyl acrylate cross-linked polymer, and the amount used is 0.02-0.5%.

[0133] The specific preparation process of the water phase includes: heating and stirring to disperse uniformly 50-99.9% of water and 0.01-5% of thickening agent, and then adding moisturizing agent, preservative, efficacy aid, neutralizing agent, etc. to prepare the water phase after cooling, % being the mass percentage of each component in the water phase; wherein the water can be a conventional solvent in the cosmetic field, such as deionized water, birch sap, rose water, aloe vera water, fermented lysate filtrate, yeast lysate filtrate, yeast fermentation product, lactobacillus fermentation product, diploid yeast fermentation product filtrate, musk rose water, galactomyces fermentation product filtrate, etc., the amount being 50-99.9%, more preferably 50-99.5%, for example, 65% of birch sap; the thickening agent can be carbomer, xanthan gum, waxes, cellulose gum, polyacrylic acid, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / decyl vinyl ether crosspolymer, acryloyldimethyltauramide / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyacryloyldimethyl taurate, sodium hyaluronate, etc., for example, carbomer or acrylates / decyl vinyl ether crosspolymer, the amount being 0.01-5%, more preferably 0.2-0.5%; the heating temperature can be 60-85°C, for example, 80°C; the stirring speed can be 300-8000 rpm, and the stirring time can be 10-60 min; the temperature can be lowered to 35-60°C after stirring; the moisturizing agent can be conventional in the art, for example, glycerin, diglycerin, polyglycerin-3, polyglycerin-10, propylene glycol, butylene glycol, trehalose, tremella polysaccharide, etc., the amount being 2-12%, for example, 7% of glycerin + 4% of diglycerin; the preservative can be conventional in the art, for example, phenoxyethanol, pentylene glycol, hexylene glycol, p-hydroxyacetophenone, ethylhexylglycerin, caprylyl oxyhydroxamic acid, caprylyl glycol, potassium sorbate, hydroxybenzoic acid ester, etc. having preservative effect; the efficacy aid can be conventional in the art, for example, sodium hyaluronate, acetylated sodium hyaluronate, acetyl hexapeptide-8, dipeptide diaminobutyroyl hydrazide dipropionic acid salt, oat kernel extract, collagen, hydrolyzed protein, beta-glucan, panthenol, allantoin, etc., for example, 3% of pentylene glycol + 0.4% of phenoxyethanol + 0.06% of ethylhexylglycerin.

[0134] The specific preparation process of the oil phase includes: after the oil curing agent and the non-silicon oil are completely dissolved by heating, the pretreated oil gel agent is added, and then homogenized and uniformly dispersed, the pre-dispersed color paste is added, and then homogenized and uniformly dispersed again, the remaining makeup effect additives, active additives, fragrance components and preservatives are added by cooling, and then homogenized and uniformly mixed to obtain the oil phase. The oil curing agent can be synthetic wax, paraffin wax, vegetable wax, microcrystalline wax, beeswax, dextrin palmitate, dextrin myristate and HDI / trimethylol hexyl lactone cross-linked polymer, etc. After being completely dissolved by heating and then cooled, the oil flowability can be reduced. The amount can be 0.3-10%, for example, 3.0% synthetic wax; the non-silicon oil can be conventional plant oil, synthetic oil ester, alkane oil in the cosmetic field, for example, hydrogenated polydecene, octyldodecanol, dicaprylyl carbonate, etc. The amount is 20-50%, for example, 30% dicaprylyl carbonate; the heating temperature can be 50-110°C, for example, 80°C; the pretreated oil gel agent can be dextrin palmitate, beeswax, dextrin myristate, etc. The amount can be 1-25%, for example, 2.5% dextrin palmitate; the color paste can be conventional color powder in the cosmetic field, which is obtained by mixing and homogenizing with a dispersing agent and oil, or by grinding uniformly. The amount can be 25-60%, for example, 50% color paste; the fragrance component can be essence, essential oil; the mass percentage of each component in the oil phase component.

[0135] In step S21, the prepared oil phase is poured or pumped into the feed pipeline. The oil phase pressure in the pipeline can be detected by a pressure sensor in the pipeline to maintain stable pressure, or the material in the valve body can be pressurized by air pressure to maintain stable pressure. Then the preparation of the foundation microspheres is controlled by the piezoelectric valve 1.

[0136] In this embodiment, the oil phase has high viscosity and low flowability at room temperature, and has the characteristics of shear thinning or thinning when heated above 30°C.

[0137] Preferably, the mass ratio of the oil phase to the water phase can be 1:(0.5-5.5), more preferably 1:(2-5). If the oil phase is too much, the prepared microspheres are not easy to disperse and are easy to stick together; if the water phase is too much, the final prepared microsphere foundation has poor hiding power;

[0138] The viscosity of the oil phase is 30000-100000 cp, preferably 60000-80000 cp; the density is 1.10-1.60 g / cm3; the viscosity of the water phase is 8000-14000 cp, preferably 10000-12000 cp; the density is 0.95-1.20 g / cm3.

[0139] Before the piezoelectric valve 1 is opened, the jetting parameters can be adjusted according to the viscosity and rheological properties of the oil phase, so as to adjust the shape and size of the microspheres. The jetting parameters include the valve opening time, the piezoelectric ratio, the distance between the piezoelectric valve 1 striker and the nozzle assembly 2, the pressure of the gap inlet 13, the air pressure of the air inlet 11, the striker rising time, the striker falling time, the initial movement speed of the striker, the impact amplitude and frequency.

[0140] After the piezoelectric valve 1 is opened, the striker inside the valve body drives the striker coupled with the lever to impact the oil phase in the valve body flow channel under the expansion and contraction of the piezoelectric ceramic, and the oil phase is sprayed out of the microspheres through the nozzle. Among them, the shape of the microspheres can be controlled by selecting different nozzles, such as spherical, triangular, water droplet, etc., and whether the microspheres are taken out with star points and long tails can also be adjusted by adjusting the falling time of the striker in the piezoelectric valve 1. Under the condition that the movement amplitude and frequency of the striker in the piezoelectric valve 1 are constant, the size of the microspheres can be adjusted by adjusting the valve opening time or the pressure of the inlet 13; under the condition that the pressure of the inlet 13 is constant, the ejection frequency of the oil phase droplets can be adjusted by adjusting the movement frequency of the striker in the piezoelectric valve 1; in addition, the nozzle can be immersed in the water phase or the nozzle does not contact the water phase liquid level, and the sprayed microspheres are directly hit into the water phase solution to form suspended microspheres, or the water phase can be introduced into the flow channel through the above microchannel structure, and the sprayed microspheres are taken out through the water phase solution, in addition, the viscosity of the water phase can be adjusted to adjust the size of the microspheres suspended in the water phase or sinking at the bottom of the water phase. Further, by adjusting the flow rate of the oil phase at the inlet 13 or adjusting the flow rate of the liquid phase at the inlet of the microfluidic module 4, the distance between the microspheres can be adjusted, and then the ball-liquid ratio of the microspheres collected can be adjusted.

[0141] For example, microspheres with a diameter of 0.4-0.8 mm are prepared, a nozzle with a pore size of 0.2 mm is selected, the uniformly stirred oil phase is poured into the barrel, the air pressure in the barrel is adjusted to 0.3 Mpa, the heating temperature of the flow channel is adjusted to 50°C, a striker with a diameter of 3.0 mm is selected, the nozzle is adjusted to be moderately tight, the piezoelectric proportion is set to 40%, the piezoelectric valve striker rising time is set to 0.2 ms, the valve opening time is set to 0.2 ms, the striker falling time is set to 0.2 ms, the microsphere ejection interval time is set to 50 ms, the water phase pump is set to a flow rate of 1 mL / min, the peristaltic pump is turned on, after the water phase flows out of the microchannel, the flow channel is infiltrated to ensure that the oil phase microspheres do not stick to the wall, and after coming out, they are directly in the water phase solution in the flow channel, the piezoelectric valve 1 is turned on, the oil phase microspheres flow out with the water phase, after the microspheres are collected in a container, the microsphere preparation is completed, the collected microspheres are observed under a microscope for morphology and size measurement, if the size does not meet the requirements, the valve opening time or piezoelectric proportion and other parameters are fine-tuned, if the requirements are met, the ejection time interval can be adjusted to 30 ms according to the requirements to improve the ejection efficiency, after normal ejection, the microfluidic module 4 is removed, the mass of the piezoelectric valve ejection is weighed on a precision balance for 1 minute, the corresponding water phase mass is calculated according to 1:4, the pump parameters are set, after weighing on a precision balance, it is confirmed that the water phase flow rate corresponds to the water phase mass, the peristaltic pump is turned on, after the water phase flows out of the microchannel, the flow channel is infiltrated to ensure that the oil phase microspheres do not stick to the wall, and after coming out, they are directly in the water phase solution in the flow channel, the piezoelectric valve is turned on, the oil phase microspheres flow out with the water phase, after the microspheres are collected in a container, the microsphere preparation is completed.

[0142] After preparation, the microsphere morphology is evaluated according to the following standards:

[0143] (1) Particle size distribution: observed and measured under a microscope using a cell ruler, 90% of the microspheres have a diameter of 0.5-0.7 mm;

[0144] (2) Particle size uniformity: evaluated by the range of particle size measured by the experimenter, requiring uniformity of roundness, 5% of the microspheres have a diameter of 0.4-0.5 mm, and 5% of the microspheres have a diameter of 0.7-0.8 mm;

[0145] (3) Regularity: evaluated by the experimenter using the proportion of irregular microspheres, with an irregularity of 1%-10%.

[0146] Example Two

[0147] As Figure 5 , 6As shown, the high-throughput microsphere production preparation system provided by the second embodiment adopts a proportional regulating valve 6 as the valve assembly, the outlet of the valve assembly is the switch nozzle of the proportional regulating valve 6, the proportional regulating valve 6 has a first fluid channel connecting the inlet and the switch nozzle, the first fluid channel is used to transport the first fluid to the switch nozzle of the proportional regulating valve 6, and the switch nozzle is connected to the nozzle assembly 2. The outlet of the proportional regulating valve 6 is connected to the inlet of the microfluidic module 4 through an outlet pipe (not shown in the figure).

[0148] Specifically, the difference between the present embodiment and the first embodiment is that the output control of the first fluid is realized by the proportional regulating valve 6 instead of the piezoelectric valve 1. Similar to the piezoelectric valve 1, the proportional regulating valve 6 also has an inlet, an outlet, and an inlet connected to the first fluid channel, and the proportional regulating valve 6 is also provided with a pressure device for providing positive pressure on the inlet pipeline, but the proportional regulating valve 6 does not have a striker structure, and the output of the first fluid in the form of uniform droplets is not realized by the high-frequency impact of the striker, but is realized by the combined action of the air flow pushing and the quick switching of the switch nozzle.

[0149] Correspondingly, a proportional valve controller is also included, which is electrically connected to the proportional regulating valve 6 and is used to adjust the valve opening time, the switch time of the switch nozzle, and the air pressure in the valve body, so as to accurately control the output flow of the first fluid. When the proportional regulating valve 6 is working, the switch nozzle performs quick switching action, which can realize high-frequency and accurate output.

[0150] Similarly, the controller of the heating element and the temperature measuring element in the temperature control module 3 is integrated with the proportional valve controller. Further, the proportional regulating valve 6, the temperature control module 3, and the feeding device and the gas supply device are all controlled by the same controller.

[0151] In the high-throughput microsphere production preparation system provided by the present embodiment, the other components are basically the same as those in the first embodiment. Correspondingly, the high-throughput microsphere production preparation method provided by the present embodiment is also similar to that in the first embodiment.

[0152] Similarly, the high-throughput microsphere production preparation method includes: selecting different nozzle assemblies 2 to adjust the shape of the microspheres; adjusting the size of the microspheres by adjusting the pressure of the inlet 13; and adjusting the distance between the microspheres by adjusting the flow rate of the oil phase at the inlet or adjusting the flow rate of the liquid phase at the inlet of the microfluidic module 4, so as to adjust the ratio of the microspheres to the liquid when the microspheres are collected.

[0153] The process of microsphere preparation using the proportional regulating valve 6 includes: introducing the oil phase into the proportional regulating valve 6, the oil phase is transported through the first fluid channel, after constant temperature heating of the temperature control module 3, the oil phase is impacted by the proportional regulating valve 6 switch nozzle high frequency into the nozzle assembly 2, the oil phase is sprayed out of the nozzle assembly 2 to form uniform droplets and enters the micro flow channel cavity 41, the water phase in the annular channel cavity 44 guided by the liquid flow guide 45 meets the oil phase droplets between the nozzle assembly 2 and the micro flow channel cavity 41, and the oil phase droplets are subjected to all-round vertical shearing, under the action of the all-round shearing force of the water phase, the oil phase droplets quickly shrink to form a highly regular spherical morphology, and then enter the forming cavity 42 through the micro flow channel cavity 41, further stabilize the microsphere morphology, and finally the microspheres are collected by the collection device connected to the outlet cavity 43.

[0154] Similarly, during microsphere preparation, the injection parameters can also be adjusted according to the viscosity and rheological properties of the oil phase, thereby adjusting the shape and size of the microspheres. The injection parameters of the present embodiment include valve opening time, switch nozzle opening and closing time, feed port pressure, and air inlet air pressure.

[0155] It should be noted that each embodiment in the specification is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts of each embodiment can be referred to each other. For the system disclosed in the embodiments, since it corresponds to the method disclosed in the embodiments, the description is relatively simple, and the relevant parts can be referred to the method part.

[0156] Finally, it should be noted that: the above is only the preferred embodiment of the present application, and is not used to limit the present application, although the present application has been described in detail with reference to the foregoing embodiments, for those skilled in the art, the technical solutions recorded in the foregoing embodiments can be modified, or some technical features can be replaced. Any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A high-throughput microsphere production preparation system, characterized by, The system comprises a controller and a plurality of microsphere preparation units arranged in parallel, each microsphere preparation unit comprising a valve assembly, a nozzle assembly (2), a temperature control module (3) and a microfluidic module (4), the valve assembly and the temperature control module (3) of each microsphere preparation unit being signal-connected with the controller; The feeding port of the valve assembly is connected with an external feeding device, and the discharging port of the valve assembly is connected with the nozzle assembly (2), the valve assembly being used for receiving the first fluid provided by the feeding device and controlling the output flow of the first fluid, and the nozzle assembly (2) being used for spraying the first fluid output by the valve assembly. The temperature control module (3) is installed at the bottom of the valve assembly and its heating working surface is attached to the outer wall of the nozzle assembly (2), and is used for heating the first fluid before it is sprayed into the nozzle assembly (2). The microfluidic module (4) is installed at the bottom of the temperature control module (3) and its feeding port is directly opposite the discharging port of the nozzle assembly (2), and its liquid inlet is connected with an external liquid supply device, the microfluidic module (4) being used for receiving the second fluid provided by the liquid supply device and shearing and wrapping the first fluid sprayed by the nozzle assembly (2) with the second fluid flowing in the internal chamber of the microfluidic module (4) to form microspheres. A pressure device is arranged in the feeding pipeline of the valve assembly, the pressure device being used for providing positive pressure to adjust the size of the microspheres, and adjusting the distance between the microspheres by adjusting the flow rate of the oil phase at the feeding port or adjusting the flow rate of the water phase at the inlet of the microfluidic module (4).

2. The high-throughput microsphere production preparation system of claim 1, wherein, The valve assembly is a piezoelectric valve (1), the piezoelectric valve (1) being provided with a piezoelectric ceramic, a displacement amplification mechanism, a striker and a first fluid channel (14), the first fluid channel (14) being connected with the feeding port (13) of the piezoelectric valve (1) and the working area of the striker, the first fluid channel (14) being used for conveying the first fluid to the working area of the striker, the working area of the striker being connected with the nozzle assembly (2) through the discharging port of the piezoelectric valve (1), and the piezoelectric ceramic driving the striker to impact the fluid in the working area of the striker at a high frequency through the displacement amplification mechanism.

3. The high-throughput microsphere production preparation system of claim 2, wherein, The piezoelectric valve (1) is provided with an adjusting knob (12) for adjusting the gap between the striker and the nozzle assembly (2), the inner wall of the nozzle assembly (2) being shaped to match the shape of the head of the striker, and the head of the striker being attached to the inner wall of the nozzle assembly (2) to form a linear seal or a face seal when the striker is in the initial position.

4. The high-throughput microsphere production preparation system of claim 2, wherein, A piezoelectric valve controller is further provided, the piezoelectric valve controller being electrically connected with the piezoelectric valve (1) and being used for adjusting the rising time, falling time, initial movement speed, impact frequency and impact amplitude of the striker.

5. The high-throughput microsphere production preparation system of claim 1, wherein, The valve assembly is a proportional regulating valve (6), the discharging port of the valve assembly being the switch nozzle of the proportional regulating valve (6), the proportional regulating valve (6) being provided with a first fluid channel connected with the feeding port and the switch nozzle of the proportional regulating valve (6), the first fluid channel being used for conveying the first fluid to the switch nozzle of the proportional regulating valve (6), and the switch nozzle being connected with the nozzle assembly (2).

6. The high-throughput microsphere production preparation system of claim 5, wherein, Further comprising a proportional valve controller electrically connected to the proportional regulating valve (6) for adjusting the opening and closing time of the switch nozzle and the air pressure in the valve body, thereby controlling the output flow of the first fluid.

7. The high-throughput microsphere production preparation system of claim 1, wherein, An elastic sealing gasket (5) is arranged between the nozzle assembly (2) and the discharge port of the valve assembly.

8. The high-throughput microsphere production preparation system of claim 1, wherein, The valve assembly has an air inlet (11) communicating with the first fluid channel (14) of the valve assembly, and an external air supply device supplies air to the valve assembly through the air inlet (11) to increase the fluidity of the first fluid.

9. The high-throughput microsphere production preparation system of claim 1, wherein, The microfluid module (4) has a microfluid channel cavity (41), a shaping cavity (42) and a lead-out cavity (43) arranged in sequence from top to bottom, and the central axes of the microfluid channel cavity (41), the shaping cavity (42) and the lead-out cavity (43) coincide with the central axis of the nozzle assembly (2); The microfluid channel cavity (41) and the lead-out cavity (43) are both cylindrical, and the aperture of the microfluid channel cavity (41) is larger than the aperture of the outlet end of the nozzle assembly (2); The shaping cavity (42) is trumpet-shaped, and the small-diameter end and the large-diameter end of the shaping cavity (42) are respectively communicated with the microfluid channel cavity (41) and the lead-out cavity (43).

10. The high-throughput microsphere production preparation system of claim 9, wherein, The microfluid module (4) also has an annular channel cavity (44); The side wall of the microfluid module (4) has a liquid flow guide (45) for guiding the second fluid from the external liquid supply device into the annular channel cavity (44); The central axis of the annular channel cavity (44) coincides with the central axis of the nozzle assembly (2); The nozzle assembly (2) has a gap between the microfluid channel cavity (41), and the annular channel cavity (44) communicates the gap between the microfluid channel cavity (41) and the nozzle assembly (2).

11. A method of producing a high-throughput microsphere production system according to any one of claims 1-10, characterized in that, The method comprises the following steps: Step S1, water phase preparation and oil phase preparation are carried out; Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation; Wherein, the oil phase flows into the internal cavity of the microfluid module (4) of the valve assembly through the valve assembly and the nozzle assembly (2) of the microsphere preparation unit, the water phase flows into the internal cavity of the microfluid module (4) from another direction, and the oil phase droplets sprayed by the nozzle assembly (2) are subjected to shearing and wrapping treatment to form microspheres; The step S1, water phase preparation and oil phase preparation include: Step S11, heat and stir the water and thickening agent to disperse uniformly, then add moisturizing agent, preservative, efficacy aid, neutralizing agent to prepare the water phase; Step S12, heat and dissolve the oil curing agent and non-silicon oil completely, then add the pretreated oil gel agent, uniformly disperse after homogenization, then add the pre-dispersed color paste, uniformly disperse again, then add the remaining makeup effect aid, active aid, fragrance component and preservative, and uniformly mix to obtain the oil phase.

12. The method of claim 11, wherein, Step S2, the water phase and the oil phase are transported to a plurality of microsphere preparation units arranged in parallel for microsphere preparation; The microsphere preparation unit is a piezoelectric valve (1) having a striker and a first fluid channel (14) for delivering an oil phase to the striker working area which is connected to the nozzle assembly (2); In step S21, the oil phase is introduced into the piezoelectric valve (1), and the oil phase is delivered through the first fluid channel (14) and is heated by the temperature control module (3) to a constant temperature. The oil phase is then impacted by the striker of the piezoelectric valve (1) at a high frequency and enters the nozzle assembly (2). The oil phase is sprayed through the nozzle assembly (2) to form uniform droplets and enters the microchannel cavity (41). The water phase introduced into the annular channel cavity (44) through the liquid flow guide (45) meets the oil phase droplets through the gap between the nozzle assembly (2) and the microchannel cavity (41), realizing omnidirectional vertical shearing of the oil phase droplets. Under the action of the omnidirectional shearing force of the water phase, the oil phase droplets rapidly contract to form a highly regular spherical morphology. The microspheres then enter the forming cavity (42) through the microchannel cavity (41) to further stabilize the microsphere morphology. Finally, the microspheres are collected by the collection device connected to the discharge cavity (43).

13. The preparation method according to claim 11, characterized in that, In step S2, the water phase and the oil phase are delivered to a plurality of microsphere preparation units arranged in parallel for microsphere preparation, which includes: The microsphere preparation unit is a proportional control valve (6) having a first fluid channel for delivering an oil phase to the switch nozzle of the proportional control valve (6) which is connected to the nozzle assembly (2); In step S21, the oil phase is introduced into the piezoelectric valve (1), and the oil phase is delivered through the first fluid channel (14) and is heated by the temperature control module (3) to a constant temperature. The oil phase is then impacted by the striker of the piezoelectric valve (1) at a high frequency and enters the nozzle assembly (2). The oil phase is sprayed through the nozzle assembly (2) to form uniform droplets and enters the microchannel cavity (41). The water phase introduced into the annular channel cavity (44) through the liquid flow guide (45) meets the oil phase droplets through the gap between the nozzle assembly (2) and the microchannel cavity (41), realizing omnidirectional vertical shearing of the oil phase droplets. Under the action of the omnidirectional shearing force of the water phase, the oil phase droplets rapidly contract to form a highly regular spherical morphology. The microspheres then enter the forming cavity (42) through the microchannel cavity (41) to further stabilize the microsphere morphology. Finally, the microspheres are collected by the collection device connected to the discharge cavity (43).

14. The production method according to claim 12 or 13, characterized by, Further comprising: Adjusting the shape of the microspheres by selecting different nozzle assemblies (2).

15. The method of claim 12, wherein, Further comprising: Adjusting the shape of the microspheres by adjusting the drop time of the striker in the piezoelectric valve (1); Under the condition that the amplitude and frequency of the striker movement in the piezoelectric valve (1) are constant, the size of the microspheres is adjusted by adjusting the pressure of the feed inlet (13); and Under the condition that the pressure of the feed inlet (13) is constant, the ejection frequency of the oil phase droplets is adjusted by adjusting the movement frequency of the striker in the piezoelectric valve (1).

16. The production method according to claim 12 or 13, characterized by, Further comprising: The distance between the microspheres is adjusted by adjusting the flow rate of the oil phase at the feed port (13) or by adjusting the flow rate of the water phase at the inlet of the microfluidic module (4), thereby adjusting the ratio of microspheres to liquid when the microspheres are collected.

17. The method of claim 11, wherein, In step S11, the water is one or more of deionized water, birch sap, rose water, aloe vera leaf water, fermented lysate filtrate, yeast lysate filtrate, yeast fermentation product, lactobacillus fermentation product, diploid yeast fermentation product filtrate, musk rose water, galactomyces fermentation product filtrate, in an amount of 50%-99.5%; The thickening agent is one or more of carbomer, xanthan gum, welan gum, cellulose gum, polyacrylic acid, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / decyl acetate crosspolymer, ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacryloyldimethyl taurate, sodium hyaluronate, in an amount of 0.015%; The humectant is one or more of glycerin, diglycerin, polyglyceryl-3, polyglyceryl-10, propylene glycol, butylene glycol, trehalose, tremella fuciformis sporophores extract; The preservative is one or more of phenoxyethanol, pentylene glycol, hexylene glycol, p-hydroxyacetophenone, ethylhexylglycerin, caprylyl glycol, potassium sorbate, and methylparaben, which have a preservative effect; The efficacy aid is one or more of sodium hyaluronate, sodium acetylhyaluronate, acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, avena sativa (oat) kernel extract, collagen, hydrolyzed protein, beta-glucan, panthenol, and allantoin; The neutralizing agent is one or more of tromethamine, sodium hydroxide, arginine, aminomethyl propanol, and sodium citrate; The heating temperature is 60-85℃; The stirring speed is 300-8000rpm, and the stirring time is 10-60min; After stirring, the temperature is lowered to 35-60℃.

18. The method of claim 11, wherein, In step S12, the oil curing agent is one or more of synthetic wax, paraffin wax, vegetable wax, microcrystalline wax, beeswax, dextrin palmitate, dextrin myristate, and HDI / trihydroxymethyl hexyl lactone crosspolymer, in an amount of 0.3-10%; The non-silicon oil is one or more of plant oil, synthetic oil ester, or alkane oil, in an amount of 20-50%; The heating temperature is 50-110℃; The pretreated oil gel agent is one or more of lithium montmorillonite disodium dimethylamide, and castor oil / IPDI copolymer, in an amount of 1-25%; The color paste is obtained by uniformly mixing or grinding the color powder with the dispersant and oil, in an amount of 25-60%; The cosmetic effect aid is one or more of synthetic fluorphlogopite, bismuth oxychloride, mica, silica, perlite, and gem powder; The active aid is one or more of tocopherol, bisabolol, and spilanthes extract; The fragrance component is one or more of fragrance or essential oil.

19. The preparation method according to claim 18, characterized in that, The thickening agent is one or more of carbomer or acrylates / ethylhexyldecylcrotonate crosspolymer in an amount of 0.02-0.5%. The thickening agent is one or more of carbomer or acrylates / ethylhexyldecylcrotonate crosspolymer in an amount of 0.02-0.5%.

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