Establishment and application method of acute pneumonia animal model for acinetobacter baumannii vaccine immune effect test

By establishing an acute pneumonia animal model in BALB/c mice and administering different doses of live Acinetobacter baumannii in groups, the problem of poor model controllability in existing technologies was solved, and a highly reliable and reproducible vaccine effect assessment was achieved.

CN121241981APending Publication Date: 2026-01-02CHENGDU OLYMVAX BIOPHARM
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Patent Information

Application Number
CN202511473828.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-15
Publication Date
2026-01-02

AI Technical Summary

Technical Problem

Current technologies lack animal models that can effectively simulate the common clinical infection routes, infection sites, pathogenic mechanisms and pathological changes of Acinetobacter baumannii. Furthermore, existing models are cumbersome to operate, have poor controllability, and cannot accurately assess the immunoprotective effect of vaccines.

Method used

An acute pneumonia animal model was established using BALB/c mice. Different doses of Acinetobacter baumannii live bacterial solution were administered to different groups of mice. Combined with strict feeding and environmental control, statistical analysis was conducted to ensure the reliability and reproducibility of the model.

Benefits of technology

This provides a highly reliable and reproducible animal model that can accurately simulate clinical infection with Acinetobacter baumannii, improving the accuracy and controllability of vaccine efficacy assessment. It is applicable to different strains and animal species, facilitating cross-sectional comparison of different experimental results.

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Abstract

The invention discloses an establishment and application method of an acute pneumonia animal model for an acinetobacter baumannii vaccine immune effect test, and the method comprises the following steps: S1, screening experimental animals, and feeding; s2, experiment grouping and identification; s3, constructing an animal model; and S4, performing data statistical analysis. According to the animal model, common clinical infection pathways, infection parts, pathogenesis, pathological changes and clinical manifestations of the acinetobacter baumannii can be simulated to the maximum extent, and the pertinence and accuracy of candidate vaccine curative effect judgment and prediction are improved.
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