Composition containing thiazolidinone acaricide and application thereof

Abstract

The invention relates to a composition containing thiazolidinone acaricides and application thereof, the composition comprises a compound shown as a formula (I) and an active compound shown as a group (II), the active compound shown as the group (II) is selected from (3), (6), (10), (12), (13), (20), (21), (23) or (25) of an insecticide group (IRAC classification group), and the weight part ratio of the compound shown as the formula (I) to the active compound shown as the group (II) is 1: 99-99: 1. The composition disclosed by the invention has a remarkable synergistic effect, can effectively improve the prevention and control effects on agricultural pests, urban health pests and pest mites, reduces the dosage and cost, delays the generation of pest resistance to drugs, can be prepared into various dosage forms, and is widely applied to pest prevention and control in the fields of agriculture, forestry and urban health.

Description

Technical Field

[0001] This invention relates to the field of pesticide compositions, and more specifically to a composition of a thiazolidinone acaricide containing trifluoroethylphenyl sulfide and its application. Background Technology

[0002] The compound of formula (I) and its preparation method have been disclosed in patent CN119528843A. This compound belongs to the novel trifluoroethane sulfoxide (sulfoxide) class of thiazolidinone acaricides. It has significant characteristics such as novel structure and excellent acaricidal activity. It shows good control effect on all growth stages of mites and has broad market application prospects.

[0003] In pest control practices, long-term use of single-active insecticides can easily lead to pesticide resistance in pests, resulting in decreased control efficacy, increased pesticide dosage, and other problems. This not only drives up control costs and exacerbates environmental pollution but also significantly increases the risk of pesticide residues in agricultural products. By combining two active ingredients in a specific ratio to create a mixed insecticide and acaricide, control efficacy can typically be improved, the dosage of the active ingredient reduced, and costs lowered, while simultaneously delaying the development of pesticide resistance in pests. However, the choice of which two substances to combine is not arbitrary, and whether it can achieve synergistic effects and broaden the control spectrum is highly uncertain. If a combination can improve efficacy, reduce costs, and increase efficiency, it has excellent market prospects; therefore, such synergistic combinations have always been a goal pursued by the industry.

[0004] Existing insecticide and acaricide compositions have varying focuses, making it difficult to achieve highly effective control. Therefore, there is an urgent need to develop novel active compound compositions with synergistic effects. Summary of the Invention

[0005] The purpose of this invention is to overcome the technical problem of low pest / mite control efficiency in the prior art, and to provide a composition of a thiazolidinone acaricide based on trifluoroethyl phenyl sulfide. This composition has the advantages of improving control efficacy, broadening the control spectrum, and effectively delaying the development of pesticide resistance in pests.

[0006] Compounds of formula (I) can be used to control a variety of pests, especially agricultural mites, which have outstanding control effects. In particular, these compounds have good control effects on a variety of mites and pests, such as carmine spider mite, citrus pterocaryon, citrus rust mite, two-spotted spider mite, hawthorn spider mite, apple spider mite, gall mite, flour mite, and nematodes.

[0007] The inventors of this invention, through research on the mixing of compounds of formula (I) with existing insecticides, acaricides or fungicides, unexpectedly discovered that when compounds of formula (I) and active compounds of group (II) are used in combination, especially in a certain proportion, they have a more superior effect in the control of pests, mites or diseases, thus proposing this invention.

[0008] A first aspect of the present invention provides a composition comprising a compound of formula (I) and an active compound of group (II).

[0009] The compounds of formula (I) are selected from... ,

[0010] The compounds in group (II) are selected from the suicide group (IRAC classification group) (3), (6), (10), (12), (13), (20), (21), (23) or (25).

[0011] The weight ratio between the compound of formula (I) and the active compound of group (II) is 1:99 to 99:1.

[0012] According to some embodiments of the present invention, the weight ratio of the compound of formula (I) to the active compound of group (II) is 1:99 to 99:1, for example 1:1, 1:2, 1:2.5, 1:4, 1:5, 1:6, 1:8, 1:10, 1:20, 1:30, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:99, 99:1, 90:1, 85:1, 80:1, 70:1, 60:1, 50:1, 40:1, 30:1, 20:1, 10:1, 8:1, 6:1, 5:1, 4:1, 2.5:1, 2:1 or any value between the above values.

[0013] Furthermore, the compositions of the present invention preferably comprise synergistically effective amounts of compounds of formula (I) and compounds of group (II). Group (II) consists of the following:

[0014] Insecticide group (IRAC (Insecticide Resistance Action Committee) mode of action classification group; also known as "IRAC classification group"): (3), (6), (10), (12), (13), (20), (21), (23), or (25). Further definitions are as follows:

[0015] (3) Sodium channel modulator, preferably a pyrethroid, selected from bifenthrin, cyhalothrin, fenpropathrin, acridine, brofluthrinate, and preferably the compounds mentioned above;

[0016] (6) Glutamate-gated chloride channel (GluCl) allosteric modulators, selected from abamectin, ivermectin, emamectin benzoate, alkenyl emamectin, milbemycins, lepimectin, and milbemycin oxime, with the compounds mentioned above being preferred;

[0017] (10) A mite growth inhibitor selected from clofentezine, diflovidazin, etoxazole, and hexythiazox, with the compounds mentioned above being preferred;

[0018] (12) Inhibitors of mitochondrial ATP synthase, such as ATP interfering agents, such as diafenthiuron or organotin compounds, such as azocyclotin, fenbutatin oxide, cyhexatin, triphosphorustin, propargite, propargite, tetradifon or tetradifon, wherein the compounds mentioned above are preferred;

[0019] (13) An uncoupling agent that interferes with the proton gradient and affects oxidative phosphorylation, selected from chlorfenapyr, meptyldinocap, binapacryl, and sulphluramid, wherein the compounds mentioned above are preferred;

[0020] (20) An inhibitor of mitochondrial electron transport complex (III), selected from fluacrypyrim, flufenoxystrobin, pyriminostrobin, fluopyram, bifenazate, acequinocyl, wherein the compounds mentioned above are preferred;

[0021] (21) Mitochondrial complex I electron transport inhibitors, such as METI acaricides, such as tebufenpyrad, tolfenpyrad, fenazaquin, fenpyroximate, pyridaben, pyrimidifen, or rotenone (rotenone), wherein the compounds mentioned above are preferred;

[0022] (23) Acetyl-CoA carboxylase inhibitors, such as tetronic acid and tetramic acid derivatives, selected from spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirosulfuron, spirobutyl ester, spiromethyl butyl ester, wherein the compounds mentioned above are preferred;

[0023] (25) Mitochondrial complex II electron transport inhibitors, such as β-ketonitrile derivatives selected from cyflumetofen, cyenopyrafen, cyetpyrafen, pyflubumide, and preferably the compounds mentioned above.

[0024] The compositions of the present invention more preferably comprise synergistically effective amounts of compounds of formula (I) and compounds of group (II). Group II consists of the following substances:

[0025] (3) Sodium channel modulators, selected from (II-1) bifenthrin and (II-3) fenpropathrin;

[0026] (6) Glutamate-gated chloride channel (GluCl) allosteric regulators, selected from (II-6) abamectin, (II-7) ivermectin, and (II-8) emamectin benzoate.

[0027] (10) Mite growth inhibitor, which is selected from (II-15) etoxazole;

[0028] (12) Inhibitors of mitochondrial ATP synthase, selected from (II-16) diafenthiuron, (II-17) azocyclotin, (II-18) fenbutatin oxide, and (II-21) propargite.

[0029] (20) Inhibitors of mitochondrial electron transport complex (III), selected from (II-33) bifenazate and (II-34) acequinocyl;

[0030] (21) Inhibitors of electron transport in mitochondrial complex I, selected from (II-37) fenazaquin and (II-39) pyridaben;

[0031] (23) Acetyl-CoA carboxylase inhibitors, selected from (II-42) spirodiclofen and (II-44) spirotetramat;

[0032] (25) Inhibitors of electron transport in mitochondrial complex II, selected from (II-51) cyflumetofen, (II-52) cyenopyrafen, and (II-53) cyetpyrafen.

[0033] The synergistic effect is particularly significant when the active compounds in the compositions of the present invention are present in a certain weight ratio. However, the weight ratio of the active compounds in the active compound compositions can vary over a relatively wide range. Generally, the compositions of the present invention comprise active compounds (I) and active compounds of group (II) having the following preferred and more preferred mixing ratios, wherein the active compounds of group (II) are selected from compounds of the suicide groups (3), (6), (10), (12), (20), (21), (23), or (25).

[0034] Preferred mixing ratios: 99:1 to 1:99, such as 50:1 to 1:50, or 20:1 to 1:20.

[0035] More preferred mixing ratios: 50:1 to 1:50, such as 50:1 to 1:15, or 1:15 to 50:1, or 20:1 to 1:15, or 15:1 to 1:20, or 15:1 to 1:15, or 10:1 to 1:10, or 5:1 to 1:5.

[0036] Table 1 provides particularly preferred mixing ratios for certain specific compositions of compounds of formula (I) and group (II). Therefore, at the various mixing ratios shown, the individual active compound compositions of the mixed pair of compounds of formula (I) and group (II) shown are preferred embodiments of the present invention.

[0037] Table 1

[0038]

[0039]

[0040] The mixing ratio is based on a weight ratio. This ratio should be understood as the ratio of the active compound of formula (I) to the active compound of group (II).

[0041] The weight ratio of the compound of formula (I) to (II-1) bifenthrin, (II-7) ivermectin, (II-39) pyridaben or (II-42) spirodiclofen is 20:1 to 1:20.

[0042] The weight ratio of the compound of formula (I) to etoxazole (II-15) is 20:1 to 1:5;

[0043] The weight ratio of the compound of formula (I) to (II-3) cypermethrin, (II-6) abamectin, (II-16) bufenozide, (II-18) fenbutatin, (II-21) propargite or (II-33) bifenazate is 10:1 to 1:20.

[0044] The weight ratio of the compound of formula (I) to (II-8) emamectin benzoate or (II-37) quinidazole is 5:1 to 1:20.

[0045] The weight ratio of the compound of formula (I) to (II-17) triazole tin is 20:1 to 1:10;

[0046] The weight ratio of the compound of formula (I) to (II-34) abamectin, (II-44) spirotetramat, (II-51) dicofol or (II-52) cypermethrin is 10:1 to 1:10.

[0047] The weight ratio of the compound of formula (I) to (II-53) etoxazole is 10:1 to 1:5.

[0048] According to some preferred embodiments of the present invention, the compound of formula (I) is a compound with the structure shown in formula I-332.

[0049]

[0050] Surprisingly, the insecticidal and / or arachnid / miticidal and / or nematode-killing and / or antimicrobial and / or fungicidal and / or plant-enhancing and / or yield-increasing effects of the active compound compositions of the present invention are significantly higher than the sum of the effects of the individual active ingredients. Unexpected, genuine synergistic effects exist, rather than merely complementary / additive effects.

[0051] A second aspect of the present invention provides the use of the compositions described in the first aspect for the control of pests (especially mites) or diseases. The pests and diseases are as described above.

[0052] In this invention, the combination of active compounds (I) and active compounds (II) in the composition is suitable for controlling a variety of important agricultural and forestry pests and mites; the combination of active compounds (I) and active compounds (II) in the composition is suitable for controlling a variety of harmful bacteria, especially a variety of fungal diseases, bacterial diseases, nematode diseases, viral diseases, and a variety of storage diseases of cereals, vegetables, fruit trees, ornamental plants, lawns and tropical crops.

[0053] Specifically suitable for controlling a variety of important agricultural pests such as armyworms, beet armyworms, cotton bollworms, cutworms, cabbage armyworms, apple leafrollers, rice leaf rollers, corn borers, rice stem borers, diamondback moths, cabbage caterpillars, fall webworms, tent caterpillars, gypsy moths, migratory locusts, underground pests, leaf miners, leaf miners, aphids, leafhoppers, scale insects of flowers, potato beetles, flea beetles, thrips, mirid bugs, carmine spider mites, hawthorn spider mites, citrus spider mites, citrus rust mites, apple spider mites, two-spotted spider mites, gall mites, and flour mites, as well as urban pests such as termites, cockroaches, ants, flies, and mosquitoes. It can be used on fruit trees such as apples, pears, citrus, and lychees; cereals such as wheat and rice; legumes such as soybeans and kidney beans; cotton; vegetables such as cabbage, cauliflower, Chinese cabbage, rapeseed, tomatoes, and peppers; and flowers. When used to control urban pests, it can be used in homes, various public places, offices, as well as on trees and embankments infested with termites.

[0054] According to some embodiments of the present invention, the composition is used to control pests, mites or diseases by applying it directly or indirectly to the pests, mites or fungi or their growth medium at an effective dose of 10 to 5000 grams per hectare.

[0055] In this invention, there is no particular limitation on whether the method is direct or indirect, as long as it can achieve the purpose of preventing and controlling pests, mites, or diseases. For example, the direct method may include directly contacting the composition of this invention with insects, mites, or fungi; the indirect method may include treating the place where insects, mites, or fungi grow or appear with the composition of this invention or treating their food chain containing the composition of this invention.

[0056] The compositions of the present invention can be provided in the form of finished formulations. For example, they can be formulated as emulsifiable concentrates, suspensions, water-dispersible granules, water emulsions, microemulsions, soluble liquids, wettable powders, oil suspensions, etc., as needed.

[0057] The cumulative weight percentage content of active components I and II in the composition of the present invention is between 0.5% and 95%, preferably between 1% and 85%.

[0058] The content of the active ingredient in the composition of the present invention depends on the dosage when used alone, as well as on the mixing ratio and the degree of synergistic effect. The optimal range of the active ingredient content may vary depending on the formulation type of the composition.

[0059] The formulations of the present invention can be prepared by conventional processing methods, such as mixing the active substance with a liquid carrier (solvent) or a solid carrier, and then adding one or more adjuvants (e.g., emulsifiers, dispersants, wetting agents, binders, stabilizers, and defoamers). Preferably, in the present invention, the composition contains at least one carrier and at least one surfactant. Preferably, in all the foregoing cases, it should be ensured that the active components in the compositions of the present invention are uniformly distributed.

[0060] In this invention, the emulsifiable concentrate typically contains 10-75% active ingredient, 2-20% emulsifier, 0-20% other additives (e.g., stabilizers, penetrants, corrosion inhibitors, etc.) and solvent by weight percentage, and may also contain co-solvent if necessary.

[0061] In this invention, the suspending agent is typically milled to obtain a stable, non-depositing, flowable product. By weight percentage, the suspending agent typically contains 5-50% active ingredient, 5-15% dispersant, 0.1-10% wetting agent, 4-10% antifreeze, 0-10% other additives (e.g., defoamers, preservatives, stabilizers, penetrants, and thickeners), and the balance being a liquid carrier.

[0062] In this invention, the water-dispersible granules are typically formulated as 10-100 international standard sieve mesh (1.676-0.152 mm) particles, which can be prepared by extrusion, impregnation, or spray granulation methods. By weight percentage, the water-dispersible granules typically contain 0.5-80% active ingredient and 5-20% adjuvants (e.g., dispersants, wetting agents, disintegrants, and binders), with the balance being an inert carrier.

[0063] In this invention, the wettable powder typically contains 10-85% active ingredient by weight, 3-10% dispersant in addition to a solid inert carrier, and may also contain 0-10% wetting agent and / or other additives (e.g., penetrants or stabilizers).

[0064] In this invention, the water-in-oil emulsion is formed by mixing the active ingredient, organic solvent, and surfactant to form an oil phase; water and antifreeze are then mixed together to form a homogeneous and transparent aqueous phase. The oil phase is sheared at high speed using a high-shear emulsifier, while the aqueous phase is slowly added to the oil phase simultaneously. By weight percentage, the water-in-oil emulsion typically contains 1-60% active ingredient, 5-20% surfactant, 2-10% antifreeze, and the balance being water.

[0065] In this invention, the microemulsion is a homogeneous, transparent liquid formed by mixing the active ingredient, organic solvent, emulsifier, and water together. By weight percentage, the microemulsion typically contains 1-50% active ingredient, 10-40% emulsifier, 40-60% organic solvent, and the balance being water.

[0066] In this invention, the soluble liquid is a homogeneous, transparent liquid formed by mixing the active ingredient, organic solvent, and surfactant together. By weight percentage, the soluble liquid typically contains 1-50% active ingredient, 6-20% surfactant, and the balance being organic solvent.

[0067] In this invention, the oil suspension is produced by adding the active component, surfactant, and oil-based carrier to a sand mill and milling until the particle size meets the requirements. By weight percentage, the oil suspension typically contains 2-60% active component, 6-20% surfactant, and the remainder oil-based carrier.

[0068] In this invention, aqueous dispersions and emulsions (e.g., compositions obtained by diluting the emulsifiable concentrate, wettable powder, or concentrate of this invention with water) are also within the scope of this invention. The emulsions described above (including the aforementioned forms) may be water-in-oil or oil-in-water, and may have a thick, paste-like consistency.

[0069] Compared with the prior art, the present invention has the following significant advantages:

[0070] 1. Significant synergistic effect: Within a certain ratio range, the active compound composition of the present invention has a significantly higher insecticidal and acaricidal effect than the sum of the effects of each single active ingredient compound, exhibiting a significant synergistic effect, which can effectively improve the control effect of pests and better address the problem of pest control.

[0071] 2. Reduced usage costs and environmental impact: Due to the synergistic effect of the composition, the dosage used in practical applications is significantly lower than that of individual compounds. This not only reduces the cost of pesticide use and alleviates the economic burden on farmers, but also reduces pesticide pollution of soil, water, air, and other environments, lowers the risk of pesticide residues in agricultural products, and is conducive to the protection of the ecological environment and the improvement of agricultural product quality and safety.

[0072] 3. Delaying the development of pesticide resistance in pests: The active ingredients in the composition of this invention have different mechanisms of action for killing insects and mites, and there is no problem of cross-resistance. When used for pest control, it can kill pests from different target sites, effectively delaying the occurrence and development of pesticide resistance, extending the service life of pesticides, and providing a guarantee for long-term and effective pest control. Detailed Implementation

[0073] The endpoints and any values ​​of the ranges disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed herein.

[0074] Indoor bioactivity assay

[0075] Example 1: Indoor bioactivity assay of a composition containing compound I against female adult Tetranychus carmine.

[0076] Test basis: The test was conducted in accordance with the agricultural industry standard NY / T 1154.6-2006 "Guidelines for Indoor Bioassay Tests of Pesticides. Insecticides. Part 6: Insecticide Activity Test. Immersion Method".

[0077] Test subject: Adult female Tetranychus cinnabarinus.

[0078] 1.1 Test method for adult female Tetranychus cinnabarinus

[0079] Select broad bean seedlings with uniform growth, choosing thick and tender leaves. Cut them into two-leaf-one-stem shapes, then cut one leaf to create a one-leaf-one-stem shape. Insert each leaf into a 5mL sample bottle filled with water, collecting approximately 30 female adult mites from each leaf. Accurately weigh each test agent, dissolve it in a small amount of DMSO to prepare a 10000 mg / L stock solution. Serially dilute the stock solution to obtain the test solution. After the mites have stabilized on the leaves, immerse them in the prepared solution for 5-10 seconds. Absorb excess solution with filter paper and allow to air dry. Each treatment is repeated three times, with a blank control group using an equal proportion of DMSO and Tween solution. The experimental targets are then cultured in an artificial climate chamber (24-26 ℃, L:D = 16h:8h, RH 60%). After 72 hours, check and record the mortality of the female adult mites.

[0080] 1.2 Experimental Design

[0081] Table 2. Experimental design for mixing Formula I-332 with bifenthrin (female adult mites)

[0082]

[0083] Table 3 Experimental design for mixing Formula I-332 with cypermethrin (female adult mites)

[0084]

[0085] Table 4. Experimental design for mixing Formula I-332 with avermectin (female adult mites)

[0086]

[0087] Table 5. Experimental design for mixing Formula I-332 with ivermectin (female adult mites)

[0088]

[0089] Table 6. Experimental design for mixing Formula I-332 with emamectin benzoate (female adult mites)

[0090]

[0091] Table 7 Experimental design for mixing Formula I-332 with triazole tin (female adult mites)

[0092]

[0093] Table 8 Experimental design for mixing Formula I-332 with phenbutyltin (female adult mites)

[0094]

[0095] Table 9. Experimental design for mixing Formula I-332 with diflubenzuron (female adult mites)

[0096]

[0097] Table 10 Experimental design for mixing Formula I-332 with bifenazate (female adult mites)

[0098]

[0099] Table 11 Experimental Design for Mixing Formula I-332 with Acaricide (Adult Female Mites)

[0100]

[0101] Table 12 Experimental Design of Mixture of Formula I-332 and Pyridaben (Adult Female Mites)

[0102]

[0103] Table 13 Experimental design for mixing Formula I-332 with quinclorac (female adult mites)

[0104]

[0105] Table 14 shows the experimental design for mixing Formula I-332 with fenpropathrin (adult female mites).

[0106]

[0107] Table 15 Experimental design for mixing Formula I-332 with cypermethrin (adult female mites)

[0108]

[0109] Table 16 Experimental Design for Mixing Formula I-332 with Ethoxamer (Adult Female Mites)

[0110]

[0111] 1.3 Data Statistics and Analysis

[0112] The number of live insects and the total number of insects in each treatment were counted, and the mortality rate and corrected mortality rate for each treatment were calculated.

[0113] Mortality rate (%) = [(Insect population before treatment - Number of surviving insects after treatment) / Insect population before treatment] × 100%;

[0114] Corrected mortality rate (%) = [(treatment mortality rate - control mortality rate) / (1 - control mortality rate)] × 100%.

[0115] If the mortality rate in the blank control group is less than 5%, no adjustment is required.

[0116] Use formulas edited in Excel to perform data analysis and statistics to calculate LC. 50 The toxicity index was calculated using the Sun Yunpei method (Sun et al., 1960), and the co-toxicity coefficient was also calculated.

[0117] The co-toxicity coefficient (CTC) calculation method of Sun Yunpei (Sun et al., 1960) is used to evaluate the effect of drug mixtures. A CTC ≥ 120 indicates synergistic effects, a CTC ≤ 80 indicates antagonism, and 80 < CTC < 120 indicates additive effects. The co-toxicity coefficient (CTC) is calculated using formulas (1), (2), and (3):

[0118] ┈┈┈┈┈┈┈┈┈┈┈┈┈(1;

[0119] In the formula:

[0120] ATI – The measured toxicity index of the mixture;

[0121] S-----EC50 of the standard reagent, in milligrams per liter (mg / L);

[0122] M-----EC50 of the mixture, in milligrams per liter (mg / L).

[0123] ┈┈┈┈┈┈┈┈┈┈┈┈(2;

[0124] In the formula:

[0125] TTI ----- Theoretical toxicity index of the mixture;

[0126] TIA – Toxicity Index of Agent A;

[0127] PA-----Percentage content of agent A in the mixture, expressed as percentage (%);

[0128] TIB—Toxicity index of drug B;

[0129] PB-----Percentage content of agent B in the mixture, expressed as percentage (%).

[0130] ┈┈┈┈┈┈┈┈┈┈ (3;

[0131] In the formula:

[0132] CTC—Cotoxicity Coefficient;

[0133] ATI – Actual Measured Toxicity Index of Mixtures;

[0134] TTI – Theoretical Toxicity Index of Mixed Agents.

[0135] 1.4 Test Results

[0136] Table 17 Results of indoor activity assays of Formula I-332 and bifenthrin against adult female spider mites (Tetranychus carmine).

[0137]

[0138] The results of the combined toxicity assay of compound I-332 and bifenthrin in different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50 value against adult female Tetranychus carmine: 50 The LC50 value for bifenthrin against adult female Tetranychus carmine was 0.2039 mg / L. 50 The value was 3.0846 mg / L. I-332 and bifenthrin had a synergistic effect on adult female Tetranychus carmine in the range of 20:1 to 1:20 (Table 17).

[0139] Table 18 Results of indoor activity assays of Formula I-332 and cypermethrin against adult female spider mites (Tetranychus carmine).

[0140]

[0141] The results of the combined toxicity assay of compound I-332 and cypermethrin in different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50 value against adult female Tetranychus carmine: 50 The value was 0.2807 mg / L, indicating that cypermethrin had an LC50 value against adult female Tetranychus carmine. 50 The value was 23.8399 mg / L. I-332 and cypermethrin had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:20 (Table 18).

[0142] Table 19 Results of indoor activity assays of Formula I-332 and avermectin against adult female Tetranychus carmine.

[0143]

[0144] The results of the combined toxicity assay of compound I-332 and avermectin in different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50 value against adult female Tetranychus carmine: 50 The value was 0.1905 mg / L, indicating that avermectin had a LC50 value against adult female Tetranychus carmine. 50 The value was 0.003511 mg / L. I-332 and abamectin had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:20 (Table 19).

[0145] Table 20 Results of indoor activity assays of Formula I-332 and ivermectin against adult female Tetranychus carmine.

[0146]

[0147] The results of the combined toxicity assay of compound I-332 and ivermectin in different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus carmine: 50 The value was 0.1875 mg / L, indicating that ivermectin had a LC50 value against adult female Tetranychus carmine. 50 The value was 0.01138 mg / L. I-332 and ivermectin had a synergistic effect on adult female Tetranychus carmine in the range of 20:1 to 1:20 (Table 20).

[0148] Table 21 Results of indoor activity assays of Formula I-332 and emamectin benzoate against adult female Tetranychus carmine.

[0149]

[0150] The combined toxicity assay of compound I-332 with different ratios of emamectin benzoate against adult female Tetranychus carmine showed that: I-332 had the following LC50 value against adult female Tetranychus carmine: 50The LC50 value for emamectin benzoate against adult female Tetranychus carmine was 0.1940 mg / L. 50 The value was 2.1292 mg / L. I-332 and emamectin benzoate had a synergistic effect on adult female Tetranychus carmine in the range of 5:1 to 1:20 (Table 21).

[0151] Table 22 Results of indoor activity assays of Formula I-332 and triazole tin against adult female Tetranychus cinnabarinus.

[0152]

[0153] The results of the combined toxicity assay of compound I-332 with triazole tin in different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50 value against adult female Tetranychus cinnabarinus: 50 The value was 0.2108 mg / L, and the LC50 value of triazole tin against adult female Tetranychus cinnabarinus was... 50 The value was 3.6431 mg / L. I-332 and triazole tin had a synergistic effect on adult female Tetranychus cinnabarinus in the range of 20:1 to 1:10 (Table 22).

[0154] Table 23 Results of indoor activity assays of Formula I-332 and phenylbutazone against adult female Tetranychus cinnabarinus.

[0155]

[0156] The results of the combined toxicity assay of compound I-332 with phenylbutazone at different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus cinnabarinus: 50 The value was 0.2186 mg / L, LC50 of phenbutyltin against adult female Tetranychus cinnabarinus. 50 The value was 4.9870 mg / L. I-332 and benzo[unclear] had a synergistic effect on adult female Tetranychus cinnabarinus in the range of 10:1 to 1:20 (Table 23).

[0157] Table 24 Results of indoor activity assays of Formula I-332 and diethyl urea against Tetranychus carmine (adult female mites).

[0158]

[0159] The combined toxicity assay results of compound I-332 and buprofen at different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50 value against adult female Tetranychus carmine: 50 The value was 0.2181 mg / L, and the LC50 of buprofen against adult female Tetranychus carmine was... 50 The value was 6.7479 mg / L. I-332 and buprofen had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:20 (Table 24).

[0160] Table 25 Results of indoor activity assays of Formula I-332 and bifenazate against female adult spider mite.

[0161]

[0162] The results of the combined toxicity assay of compound I-332 and bifenazate in different ratios against adult female Tetranychus cinnabarinus showed that: I-332 had an LC50-95% toxicity against adult female Tetranychus cinnabarinus. 50 The LC50 value for bifenazate against adult female Tetranychus cinnabarin was 0.1679 mg / L. 50 The value was 1.6120 mg / L. I-332 and bifenazate had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:20 (Table 25).

[0163] Table 26 Results of indoor activity assays of Formula I-332 and acaricide against Tetranychus cinnabarinus (adult female mites).

[0164]

[0165] The results of the combined toxicity assay of compound I-332 and acaricide in different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus cinnabarinus: 50 The value was 0.2525 mg / L, and the LC50 value of miticide quinone against adult female Tetranychus cinnabarin was [missing value]. 50 The value was 1.0985 mg / L. I-332 and acaricide quinone had a synergistic effect on adult female Tetranychus cinnabarinus in the range of 10:1 to 1:10 (Table 26).

[0166] Table 27 Results of indoor activity assays of Formula I-332 and quinacrine against adult female Tetranychus carmine.

[0167]

[0168] The combined toxicity assay results of compound I-332 and quinacrine at different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50 value against adult female Tetranychus cinnabarinus: 50 The value was 0.2628 mg / L, and the LC50 of quinclorac against adult female Tetranychus carmine was... 50 The value was 11.1655 mg / L. I-332 and quinacrine had a synergistic effect on adult female Tetranychus carmine in the range of 5:1 to 1:20 (Table 27).

[0169] Table 28 Results of indoor activity assays of Formula I-332 and pyridaben against adult female Tetranychus carmine.

[0170]

[0171] The results of the combined toxicity assay of compound I-332 and pyridaben at different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus cinnabarinus:50 The value was 0.2284 mg / L, indicating that pyridaben was effective against adult female Tetranychus carmine. 50 The value was 4.8905 mg / L. I-332 and pyridaben had a synergistic effect on adult female Tetranychus carmine in the range of 20:1 to 1:20 (Table 28).

[0172] Table 29 Results of indoor activity assays of Formula I-332 and fenfluridine against adult female Tetranychus carmine.

[0173]

[0174] The results of the combined toxicity assay of compound I-332 and tebufenozide at different ratios against adult female Tetranychus carmine showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus carmine: 50 The value was 0.1952 mg / L, indicating that chlorfenapyr was effective against adult female Tetranychus carmine. 50 The value was 0.3389 mg / L. I-332 and diflubenzuron had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:10 (Table 29).

[0175] Table 30 Results of indoor activity assays of Formula I-332 and cyprodinil against adult female Tetranychus carmine.

[0176]

[0177] The combined toxicity assay results of compound I-332 and cyprodinil in different ratios against adult female Tetranychus cinnabarin showed that I-332 had the following LC50-95% toxicity against adult female Tetranychus cinnabarin: 50 The value was 0.2381 mg / L, indicating that cyprodinil had an LC50 value against adult female Tetranychus carmine. 50 The value was 0.8468 mg / L. I-332 and cyprodinil had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:10 (Table 30).

[0178] Table 31 Results of indoor activity assays of Formula I-332 and etoxazole against adult female Tetranychus carmine.

[0179]

[0180] The results of the combined toxicity assay of compound I-332 and etoxazole at different ratios against adult female Tetranychus cinnabarinus showed that I-332 had the following LC50 value against adult female Tetranychus cinnabarinus: 50 The LC50 value for etoxazole against adult female Tetranychus carmine was 0.2260 mg / L. 50 The value was 0.1580 mg / L. I-332 and etoxazole had a synergistic effect on adult female Tetranychus carmine in the range of 10:1 to 1:5 (Table 31).

[0181] Example 2: Indoor bioactivity assay of the composition containing compound I against Tetranychus carmine nymphs.

[0182] Test basis: The test was conducted in accordance with the agricultural industry standard NY / T 1154.6-2006 "Guidelines for Indoor Bioassay Tests of Pesticides. Insecticides. Part 6: Insecticide Activity Test. Immersion Method".

[0183] Test subject: Tetranychus cinnabarinus nymphs.

[0184] 2.1 Test method for nymphs of the red spider mite

[0185] Select broad bean seedlings with uniform growth and thick, tender leaves. Cut them into two-leaf-one-stem shapes, then cut one leaf to create a one-leaf-one-stem shape. Inoculate each leaf with 5 female adult mites to allow them to lay eggs. Remove the female mites after one day. Three days after the nymphs hatch, cut the broad bean stems and insert them into 5mL sample bottles filled with water, retaining approximately 30 nymphs per leaf. Accurately weigh each test agent, dissolve it in a small amount of DMSO to prepare a 10000 mg / L stock solution, and serially dilute the stock solution to obtain the test solution. Immerse the infested leaves in the prepared solution for 5-10 seconds, absorb excess solution with filter paper, and allow to air dry. Each treatment is repeated three times, and a blank control group is included. The blank control group uses an equal proportion of DMSO and Tween aqueous solution for immersion. The experimental targets were then placed in an artificial climate chamber (24-26 ℃, L:D=16h∶8h, RH 60%) for culture. After 72 h, the mortality of nymphs was checked and recorded.

[0186] Table 32 Experimental design for mixing Formula I-332 with etoxazole (nymphal mites)

[0187]

[0188] Table 33 Experimental Design for Mixture of Formula I-332 and Proterenol (Nymphal mites)

[0189]

[0190] Table 34 Experimental design for mixing Formula I-332 with spirotetramat (nymphal mites)

[0191]

[0192] Table 35 Experimental Design for Mixing Formula I-332 with Spirodiclofen (Nymphal mites)

[0193]

[0194] 2.3 Data Statistics and Analysis Refer to 1.3 Data Statistics and Analysis in Example 1.

[0195] 2.4 Test Results

[0196] Table 36 Results of indoor activity assays of Formula I-332 and etoxazole against Tetranychus carmine (nymphs).

[0197]

[0198] The results of the combined toxicity assay of compound I-332 and etoxazole in different ratios against *Tetranychus carmine* nymphs showed that I-332 had the following LC50-95% toxicity against *Tetranychus carmine* nymphs: 50 The value was 0.07598 mg / L, and the LC50 value of etoxazole against Tetranychus carmine nymphs was... 50 The value was 0.04247 mg / L. I-332 and etoxazole had a synergistic effect on Tetranychus cinnabarinus nymphs in the range of 20:1 to 1:5 (Table 36).

[0199] Table 37 Results of indoor activity assays of Formula I-332 and Proterozoa against Tetranychus carmine (nymphs).

[0200]

[0201] The results of the combined toxicity assay of compound I-332 and propargite in different ratios against *Tetranychus carmine* nymphs showed that I-332 had the following LC50-95% toxicity against *Tetranychus carmine* nymphs: 50 The value was 0.08311 mg / L, and the LC50 value of propargite against Tetranychus carmineus nymphs was... 50 The value was 10.4488 mg / L. I-332 and propargite had a synergistic effect on Tetranychus cinnabarinus nymphs in the range of 10:1 to 1:20 (Table 37).

[0202] Table 38 Results of indoor activity assays of Formula I-332 and spirodiclofen against Tetranychus carmine (nymphs).

[0203]

[0204] The results of the combined toxicity assay of compound I-332 and spirodiclofen at different ratios against *Tetranychus carmine* nymphs showed that I-332 had the following LC50-95% toxicity against *Tetranychus carmine* nymphs: 50 The value was 0.09321 mg / L, indicating that spirodiclofen had an LC50 value against Tetranychus carmine nymphs. 50 The value was 1.3083 mg / L. I-332 and spirodiclofen had a synergistic effect on Tetranychus cinnabarin nymphs in the range of 20:1 to 1:20 (Table 38).

[0205] Table 39 Results of indoor activity assays of Formula I-332 and spirotetramat against Tetranychus carmine (nymphs).

[0206]

[0207] The results of the combined toxicity assay of compound I-332 and spirotetramat against *Tetranychus carmine* nymphs at different ratios showed that I-332 had the following LC50-95% toxicity against *Tetranychus carmine* nymphs: 50 The LC50 value for spirotetramat against Tetranychus cinnabarin nymphs was 0.07595 mg / L. 50 The value was 2.3672 mg / L. I-332 and spirotetramat had a synergistic effect on Tetranychus cinnabarinus nymphs in the range of 10:1 to 1:10 (Table 39).

[0208] The results of the above indoor tests clearly show that the compound of Formula I, when combined with dicofol, pyridaben, quinfenoxam, dicofol, difenoconazole, fenbutatin, triazophos, emamectin benzoate, ivermectin, cypermethrin, bifenthrin, etoxazole, cypermethrin, etoxazole, fenpyroximate, pyridaben, propargite, spirotetramat, or spirotetramat at appropriate mass ratios, exhibits excellent control effects against common crop mites, with a significant synergistic effect. Future field applications can reduce pesticide usage and slow the development of mite resistance. This composition can address the problems of high resistance, poor efficacy, and high dosage in the acaricide market, and has significant market application prospects.

[0209] The composition provided by this invention has the advantages of synergistic effect and broadened control spectrum. It can be used to control a variety of pests (especially mites) and plant diseases caused by a variety of fungi, bacteria, nematodes and viruses. It is particularly used to control plant diseases caused by plant mites such as carmine spider mite, citrus spider mite, two-spotted spider mite, apple spider mite, and broad mite.

[0210] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A composition comprising a thiazolidine acaricide, characterized in that, a compound of formula (I) and an active compound of group (II), wherein the compound of formula (I) is selected from , the active compound of group (II) is selected from the group of insecticides (IRAC classification group) (3), (6), (10), (12), (13), (20), (21), (23) or (25), the weight parts ratio between the compound of formula (I) and the active compound of group (II) is from 1 :99 to 99:

1.

2. The composition of claim 1, wherein, said group of insecticides (IRAC classification group) (3), (6), (10), (12), (13), (20), (21), (23) or (25) is: (3) sodium channel modulators selected from the group consisting of bifenthrin, cyhalothrin, fenpropathrin, acrinathrin, brofluthrinate; (6) glutamate-gated chloride channel (GluCl) allosteric modulators selected from the group consisting of abamectin, ivermectin, emamectin benzoate, abamectin, milbemycins, lepimectin, milbemycin oxime; (10) mite growth inhibitors selected from the group consisting of clofentezine, diflovidazin, etoxazole, hexythiazox; (12) inhibitors of mitochondrial ATP synthase selected from the group consisting of diafenthiuron, azocyclotin, fenbutatin oxide, cyhexatin, triphosphorustin, propargite, propargite, tetradifon or tetradifon; (13) uncouplers that interfere with proton gradient-dependent oxidative phosphorylation selected from the group consisting of chlorfenapyr, meptyldinocap, binapacryl, sulphluramid; (20) inhibitors of mitochondrial electron transport complex (III) selected from the group consisting of fluacrypyrim, flufenoxystrobin, pyriminostrobin, fluopyram, bifenazate, acequinocyl; (21) inhibitors of mitochondrial electron transport complex (IV) selected from the group consisting of acequinocyl, fluacrypyrim, fluopyram, pyriminostrobin, flufenoxystrobin, bifenazate, acequinocyl; (23) inhibitors of chitin biosynthesis, type 0 selected from the group consisting of buprofezin, diafenthiuron, hexythiazox, etoxazole, clofentezine, chlorfenapyr, sulfluramid, meptyldinocap, binapacryl, propargite, tetradifon, tetradifon, cyhexatin, azocyclotin, fenbutatin oxide, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, pyriminostrobin, flufenoxystrobin, fluopyram, fluacrypyrim, bifenazate, acequinocyl, py (21) a mitochondrial complex I electron transport inhibitor selected from tebufenpyrad, tolfenpyrad, fenazaquin, fenpyroximate, pyridaben, pyrimidifen or rotenone; (23) an acetyl CoA carboxylase inhibitor selected from spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, spirodic ​ 3. The composition of claim 1, wherein, ​ ​ ​ ​ ​ ​ ​ ​ (25) Mitochondrial complex II electron transport inhibitors selected from the group consisting of (II-51) cyflumetofen, (II-52) cyanopyrafen, (II-53) cyenopyrafen.

4. The composition according to claim 3, characterized in that, The weight ratio between the compound of formula (I) and the active compound of group (II) is from 20:1 to 1:

20.

5. The composition according to claim 3, characterized in that, The weight ratio between the compound of formula (I) and (II-1) bifenthrin, (II-7) ivermectin, (II-39) pyridaben or (II-42) spirodiclofen is from 20:1 to 1:20; The weight ratio between the compound of formula (I) and (II-15) clofentezine is from 20:1 to 1:5; The weight ratio between the compound of formula (I) and (II-3) fenpropathrin, (II-6) abamectin, (II-16) diafenthiuron, (II-18) fenbutatin oxide, (II-21) propargite or (II-33) bifenazate is from 10:1 to 1:20; The weight ratio between the compound of formula (I) and (II-8) emamectin benzoate or (II-37) quimacryd thiin is from 5:1 to 1:20; The weight ratio between the compound of formula (I) and (II-17) azocyclotin is from 20:1 to 1:10; The weight ratio between the compound of formula (I) and (II-34) dinocap, (II-44) spirotetramat, (II-51) cyflumetofen or (II-52) cyanopyrafen is from 10:1 to 1:10; The weight ratio between the compound of formula (I) and (II-53) cyenopyrafen is from 10:1 to 1:

5.

6. Use of a composition according to claim 1, characterized in that, The use of the composition for preparing an insecticide or acaricide for controlling agricultural pests or urban hygiene pests.

7. Use of a composition according to claim 6, characterized in that The composition is applied in an effective dose of 100-1000 g per hectare to pests to be controlled or the medium where the pests grow.

8. An insecticidal and miticidal preparation, characterized by comprising: The composition of claim 1 is used as an active ingredient mixed with a carrier and, if desired, one or more adjuvants, to produce a preparation.

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