Toothpaste with whitening effect and preparation method thereof

Abstract

The invention belongs to the technical field of daily necessities, and relates to toothpaste with a whitening effect and a preparation method thereof, the toothpaste comprises plant extracts, a humectant, a thickener, an abrasive, a foaming agent and an oral care agent, and the plant extracts comprise a grape seed extract, a pomegranate extract, an angelica sinensis extract and a moutan bark extract. The toothpaste prepared by the preparation method disclosed by the invention has a whitening effect and can be used for removing dental calculus. The grape seed extract, the pomegranate extract, the angelica sinensis extract and the moutan bark extract have a certain synergistic effect on the effects.

Description

Technical Field

[0001] This invention belongs to the field of daily necessities technology, and relates to a toothpaste with whitening effect and its preparation method. Background Technology

[0002] With the increasing awareness of oral health and aesthetic demands among the public, tooth discoloration has become a significant concern affecting consumers' social confidence and oral health. Tooth yellowing is mainly divided into two categories: extrinsic staining and intrinsic staining. Extrinsic staining originates from the adsorption and deposition of daily diet, tobacco combustion products, and oral bacterial metabolites on the enamel surface, forming a yellowish-brown pigment layer. Intrinsic staining is related to medication intake during tooth development, fluorosis, or age-related dentin pigmentation. Extrinsic staining is the core type that consumers can improve through daily oral care.

[0003] As the most basic oral care product, toothpaste currently faces significant limitations in whitening mechanisms, ingredient combinations, and efficacy stability, making it difficult to balance whitening effects with oral safety. Physical abrasion is the most traditional whitening method, relying on abrasive particles in toothpaste to remove the pigment layer from the enamel surface through mechanical friction during brushing. However, this method carries the risk of enamel abrasion, and its whitening effect is limited. Chemical bleaching technology uses oxidizing agents to oxidize and decompose the conjugated double bonds in pigment molecules, converting yellowish-brown pigments into colorless small molecules. However, these oxidizing agents can damage the lipid barrier of oral mucosal cells, potentially causing discomfort such as gingival redness and swelling, and oral ulcers, and its efficacy stability is poor.

[0004] Therefore, achieving effective whitening while protecting tooth enamel and oral mucosa and prolonging the whitening effect through scientific ingredient combinations has become a key technological requirement in the field of oral care. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a toothpaste with whitening effect and its preparation method.

[0006] To achieve this objective, the present invention employs the following technical solution:

[0007] In a first aspect, the present invention provides a toothpaste with whitening effect, the toothpaste comprising plant extracts, humectants, thickeners, abrasives, foaming agents, and oral care agents, wherein the plant extracts include grape seed extract, pomegranate extract, angelica extract, and peony bark extract.

[0008] The toothpaste prepared by this invention has whitening effects and can remove tartar. Grape seed extract, pomegranate extract, angelica extract, and peony bark extract have certain synergistic effects on the above-mentioned effects.

[0009] Preferably, the toothpaste comprises, by weight, 0.5-4 parts plant extract, 60-70 parts humectant, 0.3-0.8 parts thickener, 15-25 parts abrasive, 1-5 parts foaming agent, and 1.5-2.5 parts oral care agent.

[0010] The mass fractions of plant extracts can be selected from 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, etc. The mass fractions of humectants can be selected from 60 parts, 61 parts, 62 parts, 63 parts, 64 parts, 65 parts, 66 parts, 67 parts, 68 parts, 69 parts, 70 parts, etc. The mass fractions of thickeners can be selected from 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, etc. For abrasives, the mass fraction can be 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 parts, etc. For foaming agents, the mass fraction can be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, or 5 parts, etc. For oral care agents, the mass fraction can be 1.5, 1.8, 2, 2.2, or 2.5 parts, etc. Other specific values ​​within the above range can also be selected, and will not be elaborated on here.

[0011] Preferably, the plant extracts include, by weight parts, 0.1-0.5 parts grape seed extract, 0.5-2 parts pomegranate extract, 1-3 parts angelica extract, and 0.1-0.5 parts peony bark extract.

[0012] The mass fractions of grape seed extract can be selected from 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, and 0.5 parts, etc. The mass fractions of pomegranate extract can be selected from 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, and 1.9 parts. For Angelica sinensis extract, the mass fractions can be 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3, etc. For Paeonia suffruticosa extract, the mass fractions can be 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, etc. Other specific values ​​within the above ranges can be selected, which will not be elaborated here.

[0013] Preferably, the toothpaste further includes a composition with whitening effects.

[0014] Preferably, the whitening composition in the toothpaste is in the range of 0.1-1.5 parts by weight, such as 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, etc. Other specific values ​​within the above range can be selected, and will not be elaborated here.

[0015] Preferably, the composition with whitening effect includes dextranase, zinc citrate, sodium phytate, and erythritol.

[0016] Dextranase, zinc citrate, sodium phytate, and erythritol have a certain synergistic effect in enhancing the whitening effect of toothpaste and preventing tartar formation.

[0017] Preferably, the mass ratio of dextranase, zinc citrate, sodium phytate and erythritol is (0.01-0.5):(0.01-0.1):(0.01-0.1):(0.1-0.5).

[0018] The specific point values ​​in (0.01-0.5) can all be selected from 0.01, 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, etc.; the specific point values ​​in (0.01-0.1) can all be selected from 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, etc.; the specific point values ​​in (0.1-0.5) can all be selected from 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, etc. Other specific point values ​​within the above range can also be selected, which will not be elaborated here.

[0019] Preferably, the moisturizer comprises glycerin and / or polyethylene glycol-8.

[0020] Preferably, the foaming agent comprises sodium lauryl sulfate and / or sodium methyl lauroyl taurate.

[0021] Preferably, the friction agent comprises hydrated silica and / or calcium carbonate.

[0022] Preferably, the thickener comprises carbomer.

[0023] Preferably, the oral care agent comprises any one or a combination of at least two of the following: tetrasodium pyrophosphate, polyvinylpyrrolidone, arginine, and sodium polyaspartate.

[0024] Secondly, the present invention provides a method for preparing a toothpaste with whitening effect according to the first aspect, the method comprising:

[0025] (1) Mix the humectant and thickener together, and then mix them with the oral care agent to obtain the first mixture;

[0026] (2) Mix the foaming agent, plant extract and abrasive, and then mix with the first mixture to obtain the final product.

[0027] Preferably, the mixing temperature in step (1) is 75-85℃, such as 75℃, 76℃, 77℃, 78℃, 79℃, 80℃, 81℃, 82℃, 83℃, 84℃, 85℃, etc. Other specific point values ​​within the above range can be selected, and will not be described in detail here.

[0028] Preferably, the mixing temperature in step (2) is independently 10-40℃, such as 10℃, 12℃, 15℃, 18℃, 20℃, 22℃, 25℃, 30℃, 35℃, 40℃, etc. Other specific point values ​​within the above range can be selected, and will not be described in detail here.

[0029] Preferably, when the foaming agent, plant extract, and abrasive are mixed, they are also mixed with a composition having whitening effects.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] The toothpaste prepared by this invention has whitening effects and can also remove tartar. Grape seed extract, pomegranate extract, angelica extract, and peony bark extract have certain synergistic effects on the above-mentioned effects. Detailed Implementation

[0032] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments described are merely illustrative of the present invention and should not be construed as limiting the invention in any way.

[0033] The sources of the active ingredients in the products involved in the following examples and comparative examples are as follows (only the active ingredients are shown; other necessary excipients contained in commercially available raw materials are not described):

[0034] Polyethylene glycol-8 was purchased from Yangzi Petrochemical-BASF Co., Ltd. / Nanjing Well Pharmaceutical Group Co., Ltd. under the trade name polyethylene glycol 400;

[0035] Carbomer was purchased from Lubrizol Management (Shanghai) Co., Ltd. and its trade name was Carbomer Homopolymer Type B 974 NF.

[0036] The hydrated silica was purchased from Jiangsu Mingfan Biotechnology Co., Ltd. / Jin Sanjiang (Zhaoqing) Silicon Materials Co., Ltd., under the product name silicon dioxide (MII type or 115 type);

[0037] Polyvinylpyrrolidone was purchased from Ashland LLC under the trade name plasdone™ k-29 / 32 polymer;

[0038] Sodium polyaspartate was purchased from Beijing Yanzhishan Technology Co., Ltd. and its trade name is Aspartic Protein.

[0039] The grape seed extract was purchased from Chenguang Biotech Group Co., Ltd., and its product is marketed as grape seed extract.

[0040] The pomegranate extract was purchased from Xi'an Tianmei Biotechnology Co., Ltd., and its product is marketed as pomegranate extract.

[0041] The Angelica extract was purchased from Xi'an Tianguangyuan Biotechnology Co., Ltd. and its product was called Angelica extract.

[0042] The peony bark extract was purchased from Shaanxi Runze Xinqi Biotechnology Co., Ltd., and its product is called peony bark extract.

[0043] The dextranase was purchased from Beijing Baipusaisi Biotechnology Co., Ltd., and its product is called dextranase.

[0044] Example 1

[0045] This embodiment provides a toothpaste with whitening effects. The toothpaste comprises, by weight, 2.5 parts of plant extracts, 35 parts of glycerin, 30 parts of polyethylene glycol-8, 0.5 parts of carbomer, 3 parts of calcium carbonate, 15 parts of hydrated silica, 1.5 parts of sodium lauryl sulfate, 1.5 parts of sodium methyl lauroyl taurate, 0.5 parts of tetrasodium pyrophosphate, 0.5 parts of polyvinylpyrrolidone, 0.5 parts of arginine, 0.5 parts of sodium polyaspartate, and 1 part of a whitening composition. The plant extracts include grape seed extract, pomegranate extract, angelica extract, and peony bark extract in a weight ratio of 0.3:1.2:1.5:0.2. The whitening composition includes dextranase, zinc citrate, sodium phytate, and erythritol in a weight ratio of 0.2:0.05:0.05:0.2.

[0046] Its preparation method is as follows:

[0047] (1) After mixing glycerol, polyethylene glycol-8 and carbomer, mix them with tetrasodium pyrophosphate, polyvinylpyrrolidone, arginine and sodium polyaspartate at a temperature of 80°C.

[0048] (2) Sodium lauryl sulfate, sodium methyl lauroyl taurate, plant extracts, a whitening composition, hydrated silica, and calcium carbonate are mixed at a temperature of 25°C.

[0049] Example 2

[0050] This embodiment provides a toothpaste with whitening effects. The toothpaste comprises, by weight, 1 part plant extract, 30 parts glycerin, 30 parts polyethylene glycol-8, 0.3 parts carbomer, 3 parts calcium carbonate, 12 parts hydrated silica, 0.5 parts sodium lauryl sulfate, 1 part sodium methyl lauroyl taurate, 0.3 parts tetrasodium pyrophosphate, 0.4 parts polyvinylpyrrolidone, 0.5 parts arginine, 0.5 parts sodium polyaspartate, and 0.4 parts of a whitening composition. The plant extract includes grape seed extract, pomegranate extract, angelica extract, and peony bark extract in a weight ratio of 0.1:2:1:0.5. The whitening composition includes dextranase, zinc citrate, sodium phytate, and erythritol in a weight ratio of 0.01:0.1:0.01:0.5.

[0051] Its preparation method is as follows:

[0052] (1) After mixing glycerol, polyethylene glycol-8 and carbomer, mix them with tetrasodium pyrophosphate, polyvinylpyrrolidone, arginine and sodium polyaspartate at a temperature of 75°C.

[0053] (2) Sodium lauryl sulfate, sodium methyl lauroyl taurate, plant extracts, a whitening composition, hydrated silica, and calcium carbonate are mixed at a temperature of 10°C.

[0054] Example 3

[0055] This embodiment provides a toothpaste with whitening effects. The toothpaste comprises, by weight, 3.5 parts plant extracts, 35 parts glycerin, 35 parts polyethylene glycol-8, 0.7 parts carbomer, 5 parts calcium carbonate, 18 parts hydrated silica, 2 parts sodium lauryl sulfate, 2 parts sodium methyl lauroyl taurate, 0.5 parts tetrasodium pyrophosphate, 0.5 parts polyvinylpyrrolidone, 0.8 parts arginine, 0.5 parts sodium polyaspartate, and 1.2 parts of a whitening composition. The plant extracts include grape seed extract, pomegranate extract, angelica extract, and peony bark extract in a weight ratio of 0.5:0.5:3:0.1. The whitening composition includes dextranase, zinc citrate, sodium phytate, and erythritol in a weight ratio of 0.5:0.01:0.1:0.1.

[0056] Its preparation method is as follows:

[0057] (1) After mixing glycerol, polyethylene glycol-8 and carbomer, mix them with tetrasodium pyrophosphate, polyvinylpyrrolidone, arginine and sodium polyaspartate at a temperature of 85°C.

[0058] (2) Sodium lauryl sulfate, sodium methyl lauroyl taurate, plant extracts, a whitening composition, hydrated silica, and calcium carbonate are mixed at a temperature of 40°C.

[0059] Example 4

[0060] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Example 1 is that it does not contain dextranase. Instead, the reduced mass of dextranase is proportionally distributed to the mass of zinc citrate, sodium phytate, and erythritol. The other ingredients and their contents remain unchanged.

[0061] The preparation method is the same as in Example 1.

[0062] Example 5

[0063] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Example 1 is that it does not contain zinc citrate. Instead, the reduced mass of zinc citrate is proportionally distributed to the mass of dextranase, sodium phytate, and erythritol, while the other ingredients and contents remain unchanged.

[0064] The preparation method is the same as in Example 1.

[0065] Example 6

[0066] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Example 1 is that it does not contain sodium phytate. Instead, the reduced mass of sodium phytate is proportionally distributed to the mass of zinc citrate, dextranase, and erythritol, while the other ingredients and contents remain unchanged.

[0067] The preparation method is the same as in Example 1.

[0068] Example 7

[0069] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Example 1 is that it does not contain erythritol. Instead, the reduced mass of erythritol is proportionally allocated to the mass of zinc citrate, dextranase, and sodium phytate. The other ingredients and their contents remain unchanged.

[0070] The preparation method is the same as in Example 1.

[0071] Comparative Example 1

[0072] This embodiment provides a toothpaste with whitening effects. The only difference between this embodiment and Embodiment 1 is that it does not contain grape seed extract. Instead, the reduced mass of grape seed extract is proportionally allocated to the mass of pomegranate extract, angelica extract, and peony bark extract, while the other ingredients and their contents remain unchanged.

[0073] The preparation method is the same as in Example 1.

[0074] Comparative Example 2

[0075] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Embodiment 1 is that it does not contain pomegranate extract. Instead, the reduced mass of pomegranate extract is proportionally allocated to the mass of grape seed extract, angelica extract, and peony bark extract, while the other ingredients and their contents remain unchanged.

[0076] The preparation method is the same as in Example 1.

[0077] Comparative Example 3

[0078] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Embodiment 1 is that it does not contain Angelica sinensis extract. Instead, the reduced mass of Angelica sinensis extract is proportionally allocated to the mass of pomegranate extract, grape seed extract, and peony bark extract, while the other ingredients and their contents remain unchanged.

[0079] The preparation method is the same as in Example 1.

[0080] Comparative Example 4

[0081] This embodiment provides a toothpaste with whitening effects. The only difference between this toothpaste and that of Embodiment 1 is that it does not contain peony bark extract. Instead, the reduced mass of peony bark extract is proportionally allocated to the mass of pomegranate extract, grape seed extract, and angelica extract. The other ingredients and their contents remain unchanged.

[0082] The preparation method is the same as in Example 1.

[0083] Test Example 1

[0084] Dental calculus suppression test

[0085] Test method:

[0086] (1) Weigh 50 mg of hydroxyapatite powder accurately and place it in a 10 mL centrifuge tube. There are 3 replicates for each test group.

[0087] (2) Weigh 10 g of toothpaste into a beaker, add 30 g of water and mix to obtain a toothpaste slurry solution. After stirring evenly, centrifuge at 10000 r / min for 15 min and take the supernatant for later use.

[0088] (3) Add 5 mL of physiological saline to each hydroxyapatite powder tube, shake for 1 min, centrifuge at 10000 r / min for 10 min, and slowly discard the supernatant with a pipette. Add 5 mL of toothpaste supernatant, water, and 5% sodium pyrophosphate solution to the centrifuge tubes of the sample group, negative control group, and positive control group, respectively, shake for 1 min, centrifuge at 10000 r / min for 10 min, and slowly discard the supernatant with a pipette. Then add 5 mL of physiological saline to the centrifuge tube, shake for 1 min, centrifuge at 10000 r / min for 10 min, and slowly discard the supernatant with a pipette. Repeat the above steps twice by adding 5 mL of physiological saline to the centrifuge tube. Add 5 mL of physiological saline to the centrifuge tube and vortex for 1 min to obtain a uniformly dispersed hydroxyapatite suspension.

[0089] (4) Measure 100 mL of artificial saliva into a 200 mL beaker. Place the beaker on a temperature-controlled magnetic stirrer. When the temperature of the artificial saliva reaches 37±2℃, transfer the hydroxyapatite suspension prepared above into the beaker to start the reaction. Continuously add 0.01 mol / L sodium hydroxide solution to the beaker to keep the pH of the solution constant at 7.4. The reaction proceeds for 30 min. Immediately after the time is reached, remove 10 mL of the solution from the beaker, filter it through a 0.22 μm filter membrane, and then test it.

[0090] (5) The formation process of hydroxyapatite crystals is as follows:

[0091] Ca 2+ +3PO4 3- +H₂O→(Ca)₅(PO₄)₃[OH]+H +

[0092] If left uncontrolled, the solution pH will continue to decrease, and H+ will rise. + The molar formation rate of is the same as that of hydroxyapatite.

[0093] (6) Prepare a standard curve for calcium element, with the concentrations at each calibration point being 0 mg / L, 0.5 mg / L, 1.0 mg / L, 2.0 mg / L, 4.0 mg / L, and 6.0 mg / L, respectively. Obtain the concentration C of calcium element in the solution through the calibration curve and calculate the tartar inhibition rate.

[0094]

[0095] Where C S C represents the calcium concentration in the sample group. P The calcium concentration in the positive control group, C N The calcium concentration in the negative control group

[0096] Table 1

[0097]

[0098] As shown in Table 1, the toothpaste prepared by this invention has excellent tartar-inhibiting effects, and dextranase, zinc citrate, sodium phytate and erythritol have certain synergistic effects on the above effects; grape seed extract, pomegranate extract, angelica extract and peony bark extract also have certain synergistic effects on the above effects.

[0099] Test Example 2

[0100] Whitening efficacy test

[0101] Test method:

[0102] (1) Select cavities without decay and clean and sterilize the tooth blocks.

[0103] (2) Soak the tooth block alternately in 1% hydrochloric acid, saturated sodium carbonate, and 1% phytic acid for 1 min each, rinse thoroughly, and then stain in the prepared staining solution for 48 h. The staining sources used in this experiment were tea, coffee, soy sauce, wine, cola, fruit juice, milk tea, chocolate, and hot sauce.

[0104] (3) After removing the tooth blocks from the staining solution, rinse them clean and dry them, then use a colorimeter to measure the whiteness value of the enamel surface of each tooth block.

[0105] (4) The tooth blocks were randomly divided into groups of 6, and there were no significant differences between the tooth blocks.

[0106] (5) Mix toothpaste with water to prepare toothpaste paste at a mass ratio of 1:1.6. Use the toothpaste paste to brush 300 times at a frequency of 100 times / min to simulate brushing teeth for 3 days. After rinsing and drying, use a colorimeter to measure the whiteness value of the enamel surface of the tooth block (after 3 days).

[0107] (7) Continue to brush the tooth block after step (6) with the sample toothpaste paste at a frequency of 100 times / min for 400 times (total 700 times) to simulate brushing teeth for 7 days. After rinsing and drying, measure the whiteness value of the enamel surface of the tooth block (7 days L) with a colorimeter.

[0108] (8) Calculate the difference in whiteness value ΔL before and after simulated brushing.

[0109] Table 2

[0110]

[0111] As shown in Table 2, the toothpaste prepared by this invention has excellent whitening and inhibitory effects, and dextranase, zinc citrate, sodium phytate and erythritol have certain synergistic effects on the above effects; grape seed extract, pomegranate extract, angelica extract and peony bark extract also have certain synergistic effects on the above effects.

[0112] The above description is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Those skilled in the art should understand that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention fall within the protection and disclosure scope of the present invention.

Claims

1. A toothpaste with whitening effect, characterized in that, The toothpaste includes plant extracts, humectants, thickeners, abrasives, foaming agents, and oral care agents. The plant extracts include grape seed extract, pomegranate extract, angelica extract, and peony bark extract.

2. The toothpaste with whitening effect according to claim 1, characterized in that, The toothpaste comprises, by weight, 0.5-4 parts plant extract, 60-70 parts humectant, 0.3-0.8 parts thickener, 15-25 parts abrasive, 1-5 parts foaming agent, and 1.5-2.5 parts oral care agent.

3. The toothpaste with whitening effect according to claim 1 or 2, characterized in that, The plant extracts, by weight, include 0.1-0.5 parts grape seed extract, 0.5-2 parts pomegranate extract, 1-3 parts angelica extract, and 0.1-0.5 parts peony bark extract.

4. The toothpaste with whitening effect according to any one of claims 1-3, characterized in that, The toothpaste also includes a composition with whitening effects; Preferably, the whitening composition in the toothpaste is 0.1-1.5 parts by weight.

5. The toothpaste with whitening effect according to claim 4, characterized in that, The whitening composition includes dextranase, zinc citrate, sodium phytate, and erythritol. Preferably, the mass ratio of dextranase, zinc citrate, sodium phytate and erythritol is (0.01-0.5):(0.01-0.1):(0.01-0.1):(0.1-0.5).

6. The toothpaste with whitening effect according to any one of claims 1-5, characterized in that, The moisturizer includes glycerin and / or polyethylene glycol-8; Preferably, the foaming agent comprises sodium lauryl sulfate and / or sodium methyl lauroyl taurate.

7. The toothpaste with whitening effect according to any one of claims 1-6, characterized in that, The abrasive comprises hydrated silica and / or calcium carbonate.

8. The toothpaste with whitening effect according to any one of claims 1-7, characterized in that, The thickener includes carbomer; Preferably, the oral care agent comprises any one or a combination of at least two of the following: tetrasodium pyrophosphate, polyvinylpyrrolidone, arginine, and sodium polyaspartate.

9. A method for preparing a toothpaste with whitening effect according to any one of claims 1-8, characterized in that, The preparation method includes: (1) Mix the humectant and thickener together, and then mix them with the oral care agent to obtain the first mixture; (2) Mix the foaming agent, plant extract and abrasive, and then mix with the first mixture to obtain the final product.

10. The preparation method according to claim 9, characterized in that, The mixing temperature in step (1) is 75-85℃; Preferably, the mixing temperature in step (2) is independently 10-40°C; Preferably, when the foaming agent, plant extract, and abrasive are mixed, they are also mixed with a composition having whitening effects.

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