Rhizoma gastrodiae sensitive skin relieving and repairing composition as well as preparation method and application thereof

Abstract

The invention discloses a gastrodia elata sensitive skin relieving and repairing composition as well as a preparation method and application thereof. The gastrodia elata sensitive skin relieving and repairing composition is prepared from the following components in percentage by mass: 91%-93% of a skin protecting agent, 5.5%-7.5% of a humectant, 0.8%-1.5% of a thickening agent, 0.08%-0.12% of a solubilizer and 0.05%-0.07% of a pH regulator, the skin protective agent comprises a gastrodia elata extract and a skin protective agent 1, and the content of the gastrodia elata extract accounts for 0.15%-0.25% of the total mass of the composition; the skin protective agent 1 comprises a bifidus yeast fermentation product filtrate, 1, 2-hexanediol and p-hydroxyacetophenone, and the content of the skin protective agent 1 is 74-76% of the total mass of the composition. The gastrodia elata sensitive skin soothing and repairing composition can effectively increase the moisture content of the skin cuticle and reduce the skin transdermal water loss rate, and has a repairing effect; meanwhile, the conditions of skin redness, skin tension and skin sensitivity and discomfort can be improved, and the composition has the effects of relieving, being mild and non-irritating and being suitable for sensitive skin.

Description

Technical Field

[0001] This invention belongs to the field of skincare products, specifically relating to a soothing and repairing composition for sensitive skin made from Gastrodia elata, its preparation method, and its application. Background Technology

[0002] Due to factors such as environment, diet, and individual constitution, people's skin may experience allergies and inflammation. The skin is the largest organ in the human body and the first line of defense between internal organs and tissues. Once the skin barrier is damaged, it cannot resist external environmental damage, leading to increased inflammation and a series of skin problems such as dryness and peeling, redness and sensitivity, swelling, heat, pain, and itching. In such cases, users often use soothing and repairing compositions with barrier-repairing functions to soothe and repair the skin.

[0003] Chinese patent application number 201710115909.5 discloses an anti-allergic, moisturizing, and repairing essence. Each kilogram of essence contains the following components by weight: 5-10g trehalose, 5-10g aloe vera gel, 160-350g rosemary distillate, 10-20g broken-cell wall pine pollen, 1-5g broken-cell wall selenium-enriched yeast powder, 5-10g glycerin, 1-5g acetic acid, and the remainder is purified water. The rosemary is selected from fresh rosemary stems and leaves, the aloe vera from fresh leaves of Aloe barbadensis or Aloe vera sinensis, and the pine pollen is made from first-grade Masson pine powder from Baoshan, Yunnan. By mixing multiple plant components, allergens are reduced, resulting in virtually no allergic reactions, thus solving the problem of allergic reactions easily caused by using aloe vera gel alone.

[0004] Chinese patent application No. 202410148096.X discloses a novel anti-allergy repair essence and its preparation method. This novel anti-allergy repair essence comprises: deionized water, glycerin, a hydroxyethyl cellulose composition, carbomer, butylene glycol, sodium hyaluronate, p-hydroxyacetophenone, 1,2-hexanediol, a complex plant anti-allergy composition, 1,3-propanediol, saffron extract, betaine, β-glucan, hydrolyzed sugars, phenoxyethanol, ethylhexylglycerin, arginine, sodium chloride, sodium citrate, fibronectin, capryloyl hydroxyxamic acid, mussel adhesive protein, mannitol, trehalose, serum protein, PEG-40 hydrogenated castor oil, and fragrance. This method effectively solves the problems of flocculation inactivation and precipitation of multi-protein compounds, resulting in a significantly higher unit concentration of functional proteins compared to existing products.

[0005] Currently, the soothing and anti-allergic effects of anti-allergy repair serums need further improvement. Therefore, this invention is proposed. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a Gastrodia elata soothing and repairing composition for sensitive skin, its preparation method and application, which can effectively increase the moisture content of the stratum corneum of the skin, reduce the transepidermal water loss rate of the skin, and has a repairing effect; at the same time, it can also improve the skin redness, tightness and skin sensitivity and discomfort, and has the effects of soothing, gentle and non-irritating, and suitable for sensitive skin.

[0007] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by the present invention is as follows:

[0008] This invention provides a Gastrodia elata-based soothing and repairing composition for sensitive skin, comprising the following ingredients in weight percentages:

[0009]

[0010] The skin protectant comprises Gastrodia elata extract and skin protectant 1, wherein the content of Gastrodia elata extract is 0.15%-0.25% of the total mass of the composition; and the skin protectant 1 comprises Bifida ferment filtrate, 1,2-hexanediol and p-hydroxyacetophenone, wherein the content is 74%-76% of the total mass of the composition.

[0011] Experiments have shown that the Gastrodia elata soothing and repairing composition for sensitive skin of the present invention can effectively increase the moisture content of the stratum corneum of the skin and reduce the transepidermal water loss rate, thus having a repairing effect. At the same time, it can also improve skin redness, tightness, and skin sensitivity and discomfort, and has a soothing, gentle, and non-irritating effect suitable for sensitive skin.

[0012] The sensitive skin soothing and repairing composition containing Gastrodia elata of the present invention contains a variety of skin protectants and moisturizers, with appropriate proportions of each component, which can play a synergistic role and improve skin sensitivity in a short time. Among them, Gastrodia elata extract and skin protectant 1 containing Bifida ferment lysate filtrate have a synergistic effect, which can enhance the improvement effect.

[0013] In a further embodiment, the skin protectant also includes:

[0014] Skin protectant 2, comprising tea water, dipropylene glycol, 1,2-hexanediol and p-hydroxyacetophenone, in an amount of 11.5%-12.5% ​​of the total mass of the composition;

[0015] Skin protectant 3 comprises lactobacillus / soy milk fermentation product filtrate, butylene glycol, 1,2-pentanediol and water, in an amount of 1.8%-2.2% of the total mass of the composition;

[0016] Skin protectant 4 comprises glycerin, 1,2-hexanediol, 1,2-pentanediol, β-glucan, and water, in an amount of 0.8%-1.2% of the total mass of the composition.

[0017] In a further embodiment, the skin protectant also includes:

[0018] Skin protectant 5 comprises Dendrobium nobile extract, Quinoa seed extract, Giant kelp extract, 1,3-propanediol and water, in an amount of 0.45%-0.55% of the total mass of the composition;

[0019] Skin protectant 6 comprises Sophora flavescens root extract, Salvia miltiorrhiza root extract, Andrographis paniculata leaf extract, 1,3-propanediol and water, in an amount of 0.45%-0.55% of the total mass of the composition;

[0020] Skin protectant 7 comprises glycerin, caprylic / capric triglyceride, hydrogenated lecithin, phytosterol / octyldodecyl lauroyl glutamate, ceramide NP, sodium hyaluronate, and water, in an amount of 0.25%-0.35% of the total mass of the composition.

[0021] In a further embodiment, the skin protectant also includes:

[0022] Skin protectant 8, comprising dipotassium glycyrrhizate, at a content of 0.04%-0.06% of the total mass of the composition;

[0023] Skin protectant 9, comprising Coptis chinensis root extract and water, at a content of 0.04%-0.05% of the total mass of the composition;

[0024] Skin protectant 10, comprising patchouli leaf extract and octyldodecanol, in an amount of 0.005%-0.015% of the total mass of the composition.

[0025] In a further embodiment, the skin protectant also includes:

[0026] Skin protectant 11, comprising rosewood oil, in an amount of 0.005%-0.007% of the total mass of the composition;

[0027] Skin protectant 12 comprises hydrolyzed soybean extract, gallnut extract, myrothamnus flabellifolia leaf / stem extract, tea extract, betaine, mandelic acid, butylene glycol, and water, in an amount of 0.003%-0.005% of the total mass of the composition;

[0028] Skin protectant 13, comprising cocoa extract, in an amount of 0.0005%-0.0015% of the total mass of the composition.

[0029] In a further embodiment, the skin protectant also includes:

[0030] Skin protectant 14, comprising birch sap, in an amount of 0.00005%-0.00015% of the total mass of the composition;

[0031] Skin protectant 15, comprising methyl propylene glycol, hyaluronic acid, silanetriol, citric acid and water, in an amount of 0.00005%-0.00015% of the total mass of the composition;

[0032] Skin protectant 16 comprises a soluble collagen cross-linked polymer, 1,2-hexanediol, p-hydroxyacetophenone, and water, in an amount of 0.00005%-0.00015% of the total mass of the composition;

[0033] Skin protectant 17, comprising sea fennel callus culture filtrate, in an amount of 0.00005%-0.00015% of the total mass of the composition;

[0034] Skin protectant 18 comprises citrus fruit extract, butylene glycol, and water, in an amount of 0.00005% to 0.00015% of the total mass of the composition.

[0035] In a further embodiment, the moisturizer includes one or a combination of two or more of 1,3-propanediol, glycerin, allantoin, sodium hyaluronate, and alginic oligosaccharides.

[0036] Preferably, the moisturizer is a combination of 1,3-propanediol, glycerin, allantoin, sodium hyaluronate, and alginic oligosaccharides.

[0037] In a further embodiment, the thickener includes one or a combination of two or more of sodium polyacrylate, polyacrylate crosspolymer-6, and carbomer.

[0038] Preferably, the thickener is a combination of sodium polyacrylate, polyacrylate crosspolymer-6, and carbomer.

[0039] In a further embodiment, the solubilizer is PEG-40 hydrogenated castor oil, and the pH adjuster is tromethamine.

[0040] As one alternative specific implementation, the present invention provides a Gastrodia elata sensitive skin soothing and repairing composition, comprising the following ingredients in weight percentages:

[0041]

[0042]

[0043] This invention provides a method for preparing the Gastrodia elata sensitive skin soothing and repairing composition as described above, comprising:

[0044] (1) Add phase A raw material sequentially to the container, stir and heat to 70℃-75℃, preferably 73℃, homogenize at low speed until uniformly mixed, and keep warm while stirring; preferably, the low-speed homogenization speed is 1000-1500 rpm, the time is 2-3 minutes, and the stirring and heat-keeping time is 10 minutes.

[0045] (2) Add phase B raw material, stir and cool to 60-65℃, stir for 15-20 minutes, preferably: stir and cool to 62℃, stir for 18 minutes;

[0046] (3) Cool down to 40-43℃, add C phase raw materials in sequence, stir until uniform, continue to cool down, preferably to 42℃, add C phase raw materials in sequence, and stir at a speed of 15 rpm.

[0047] (4) Cool down to 40℃, add uniformly dispersed D-phase raw material and stir evenly. After passing the test, filter and discharge the material. After passing the test, fill, package, inspect and put into storage.

[0048] The A-phase raw material includes a portion of skin protectant (including skin protectant 1), a portion of moisturizer, thickener, and pH adjuster; the B-phase raw material includes a portion of moisturizer and a portion of skin protectant; the C-phase raw material includes a portion of skin protectant (including Gastrodia elata extract) and a portion of moisturizer; and the D-phase raw material includes a solubilizer and a portion of skin protectant.

[0049] Preferably, the A-phase raw materials include skin protectant 1, skin protectant 8, sodium polyacrylate, polyacrylate crosspolymer-6, carbomer, allantoin, sodium hyaluronate, and tromethamine.

[0050] Phase B ingredients include skin protectant 15, 1,3-propanediol, and glycerin;

[0051] Phase C ingredients include Gastrodia elata extract, skin protectants 2-7, 9-10, 12-14, 16-18, and algal oligosaccharides;

[0052] Phase D raw materials include PEG-40 hydrogenated castor oil and skin protectant 11;

[0053] Preferably, during the low-speed homogenization process, the rotation speed is 1000-1500 rpm, and the stirring time is 2-3 minutes;

[0054] Preferably, in step (1), the mixture is stirred and kept warm for 10 minutes.

[0055] In a further embodiment, the stirring speed in each step is 10-15 revolutions per minute.

[0056] The present invention also provides the application of the above-described Gastrodia elata sensitive skin soothing and repairing composition in the preparation of cosmetics;

[0057] Preferably, the Gastrodia elata sensitive skin soothing and repairing composition is an essence.

[0058] By adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art.

[0059] The Gastrodia elata soothing and repairing composition of the present invention can effectively increase the moisture content of the stratum corneum and reduce the transepidermal water loss rate, thus having a repairing effect. At the same time, it can also improve skin redness, tightness, and skin sensitivity and discomfort, and has a soothing, gentle and non-irritating effect suitable for sensitive skin.

[0060] The specific embodiments of the present invention will now be described in further detail with reference to the accompanying drawings. Attached Figure Description

[0061] The accompanying drawings, as part of this invention, are used to provide a further understanding of the invention. The illustrative embodiments and descriptions of the invention are used to explain the invention, but do not constitute an undue limitation of the invention. Obviously, the drawings described below are merely some embodiments, and those skilled in the art can obtain other drawings based on these drawings without creative effort. In the drawings:

[0062] Figure 1 This is a comparison chart of the baseline value D0 and the test values ​​D14 of the skin stratum corneum moisture content according to the present invention;

[0063] Figure 2 This is a comparison chart of the EI base value D0 and the D14 test value of this invention;

[0064] Figure 3 This is the user satisfaction evaluation result of the Gastrodia elata sensitive skin soothing and repairing composition of the present invention;

[0065] Figure 4 This is a bar chart showing the evaluation results of the product's effectiveness used by subject D14 in this invention;

[0066] Figure 5 This is an example of effective results for the subjects.

[0067] It should be noted that these accompanying drawings and textual descriptions are not intended to limit the scope of the invention in any way, but rather to illustrate the concept of the invention to those skilled in the art by referring to specific embodiments. Detailed Implementation

[0068] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0069] Experimental reagents

[0070] Bifido LPF15, Shandong Sacoruide Biotechnology Co., Ltd.;

[0071] Plant nectar TMCSH, Guangzhou Qiancaohui Biotechnology Co., Ltd.

[0072] Propanediol, Primient Covation LLC;

[0073] SWAN BRAND GLYCERINE USP, PALMEDIA(M)SDN.BHD (SWAN Brand Glycerin USP, PALMEDIA(M)SDN.BHD, Malaysia);

[0074] OPTIMEALTH 10W,AXIALYS INNOVATIONS;

[0075] SC-GLUCAN HD, HYUNDAI BIOLAND Co.,Ltd;

[0076] COVACRYL MV60, Sensient Cosmetic Technologies;

[0077] CDMC_MZ, Jiexi County Plant Extract Biotechnology Co., Ltd.

[0078] TSSA-MZ, Jiexi County Plant Extract Biotechnology Co., Ltd.

[0079] NP-Ceraphilic 1.5,NEUROPID CO.,LTD;

[0080] Gastrodia elata extract, Yunnan Saisen Biotechnology Co., Ltd.;

[0081] Allantoin (Ailiton), Shandong Ailiton New Materials Co., Ltd.;

[0082] SEPIMAX ZEN, SEPPIC SA;

[0083] Hybloom TM Sodium hyaluronate (HA-TP), Bloomage Biotechnology Co., Ltd.

[0084] 980 POLYMER, Lubrizol Advanced Materials, Inc;

[0085] SEARUSHI Marine Oligosaccharides, Marine Health Technology (Qingdao) Co., Ltd.;

[0086] RH 40, BASF (China) Co., Ltd.;

[0087] Cosmecare 715 Tromethamine, Hanning Chemical (Shanghai) Co., Ltd.;

[0088] Dipotassium glycyrrhizate A, Gansu Fanzhi Pharmaceutical Co., Ltd.;

[0089] NPY, Jiexi County Plant Extract Biotechnology Co., Ltd.

[0090] cb2-skin TM biofunctional, Ashland (China) Holdings Co., Ltd;

[0091] ROSEWOOD FG SH0042, Guangzhou Shengjiya Biotechnology Co., Ltd.;

[0092] MZ-YGX1027 Guangzhou Zhuangyu Biotechnology Co., Ltd.;

[0093] NATPURE XCO CHOCO CC864, Sensient Cosmetic Technologies;

[0094] Birch Sap HKD, JAPAN AKAGI CO.,LTD;

[0095] EPIDERMOSIL SP, EXSYMOL SAM;

[0096] " -CH Pro (Human-like Collagen Crosslinking Polymer), Zhenrong Biotechnology (Shanghai) Co., Ltd.;

[0097] CELTOSOME CRITHMUM MARITIMUM ST, SEPPIC SA;

[0098] Calmnerv CR, Shanghai Jiakai Biotechnology Co., Ltd.

[0099] Example 1

[0100] The formulation of the Gastrodia elata sensitive skin soothing and repairing composition includes:

[0101] Table 1

[0102]

[0103]

[0104]

[0105]

[0106] Preparation methods include:

[0107] 1. Add each raw material of phase A to the mixing pot in sequence, while stirring (12 rpm) and heating to 73°C. Homogenize at low speed (1000-1500 rpm) for 2-3 minutes to make it evenly mixed, and keep it warm for 10 minutes.

[0108] 2. Add phase B to phase A, stir and cool to 62°C. After stirring for 18 minutes, turn on the cooling water to cool down.

[0109] 3. Cool down to 42℃, add the C phase raw materials in sequence, stir (15 rpm) until uniform, and continue to cool down.

[0110] 4. Cool to 40℃, add the evenly dispersed D-phase raw material and stir until homogeneous. Stop the machine and take samples for testing. Clean and disinfect the filter screen, selecting an appropriate mesh size (200 mesh) based on the material consistency. Filter and discharge the material after passing the test.

[0111] 5. After passing the inspection, fill, package, and inspect again.

[0112] 6. After passing inspection, the goods are put into storage.

[0113] Wherein: Phase A includes substances with raw material serial numbers 1, 7, 12, 13, 14, 15, 18, and 19; Phase B includes substances with raw material serial numbers 3, 4, and 26; Phase C includes substances with raw material serial numbers 2, 5, 6, 8, 9, 10, 11, 16, 20, 21, 23, 24, 25, 27, 28, and 29; and Phase D includes substances with raw material serial numbers 17 and 22.

[0114] Experimental Example 1

[0115] 1. Experimental Objective and Principle

[0116] By recruiting a certain number of qualified subjects, and using instrument testing, questionnaire completion, image acquisition, and dermatologist evaluation, the transepidermal water loss rate, stratum corneum moisture content, and EI value of the subjects' facial test areas before and after product use were statistically analyzed. This was done to evaluate the repair, suitability for sensitive skin, soothing, and gentle and non-irritating effects of the cosmetic product, and to provide a basis for the cosmetic product's claims of repair, suitability for sensitive skin, soothing, and gentle and non-irritating effects.

[0117] Based on Fick's law of diffusion, under specified temperature and humidity conditions, the transepidermal water loss (TEWL) value is obtained by measuring the water vapor partial pressure gradient at different points near the epidermis (within 1 cm) per unit time and unit cross-section. Under the test conditions, the lower the TEWL value, the less transepidermal water loss per unit time and unit cross-sectional area, and the better the skin barrier function. Skin color reflects the integrity of the skin barrier and skin sensitivity, and can be used to evaluate the repair efficacy of cosmetics. The EI value reflects the amount of heme and is an important factor in determining skin color, directly reflecting the degree of inflammation; the lower the skin EI value, the better the improvement effect of skin erythema reaction. The capacitance method is used to determine the moisture content of the stratum corneum of human skin. This is based on the significant difference in dielectric constant between water and other substances. The measured skin capacitance value varies according to the different moisture contents of the stratum corneum, and this parameter can represent the moisture content of the stratum corneum.

[0118] 2. Test Sample

[0119] Table 2 Sample Description

[0120]

[0121] 3. Preparations before the experiment

[0122] 3.1 Subjects

[0123] 3.1.1 Inclusion Criteria

[0124] 1) Healthy men and women aged 18 to 55;

[0125] 2) Those who scored 3 or higher on the lactate test;

[0126] 3) Individuals with facial skin experiencing one of the following skin barrier problems: burning, redness, stinging, itching, or tightness;

[0127] 4) Those who can understand the testing process, are willing to participate in the trial, and sign a written informed consent form.

[0128] 3.1.2 Exclusion Criteria

[0129] 1) Women who are currently pregnant or breastfeeding;

[0130] 2) Those who have used antihistamines within the past week or immunosuppressants within the past month;

[0131] 3) Those who have used any anti-inflammatory drugs at the test site within the past two months;

[0132] 4) Subjects with clinically unhealed inflammatory skin diseases;

[0133] 5) Patients with insulin-dependent diabetes mellitus or those receiving treatment for asthma or other chronic respiratory diseases;

[0134] 6) Patients with immunodeficiency or autoimmune diseases;

[0135] 7) Cases where scars, pigmentation, atrophy, port-wine stains, or other blemishes at the skin test site affect the determination of test results;

[0136] 8) Individuals with highly sensitive constitutions;

[0137] 9) Subjects have participated in activities that may affect test results, such as related or other clinical trials, within the past 3 months.

[0138] 3.2 Subject Number Setting

[0139] Qualified subjects are selected according to the inclusion and exclusion criteria. Subjects voluntarily sign a written informed consent form, understand the trial process, and voluntarily participate in the trial, ensuring that the number of valid cases completed is no less than 30.

[0140] 3.3 Test Plan

[0141] 3.3.1 Scheme Design

[0142] This study aims to observe the efficacy of KPC Gastrodia elata sensitive skin soothing and repairing composition as a functional cosmetic in maintaining the normal condition of the application site; improving the transepidermal water loss rate, stratum corneum moisture content and EI value of the skin at the application site; and maintaining the moisture content of the application site or reducing the occurrence of moisture loss.

[0143] 3.3.2 Environmental Conditions

[0144] During the experiment, instrument tests were conducted under environmental conditions of 21±1℃ and 50±10% RH. Visual assessments were conducted under constant lighting conditions (LED light with a color temperature of 5500-6500K). All subjects were allowed to sit still and maintain balance for at least 30 minutes under these environmental conditions before assessments and tests could begin.

[0145] 4. Test methods

[0146] 4.1 Test Procedure

[0147] The test will be conducted from March 28, 2024 to April 11, 2024, at the constant temperature and humidity room on the 2nd floor of Guangdong Pharmaceutical University Testing Technology Service Co., Ltd., No. 56-1, Changmingshui Street, Wuguishan, Zhongshan City, Guangdong Province.

[0148] Table 3 Experimental Procedure

[0149] Project / Timeline Screening + Product Use D14 Front desk check-in ○ ○ Informed consent form and inclusion / exclusion criteria ○ — Compliance / Adverse Events — ○ Transepidermal water loss rate ○ ○ Skin stratum corneum moisture content ○ ○ EI value (facial skin hemoglobin index EI) ○ ○ Subject self-report — ○ Fill out the questionnaire — ○ Sample distribution ○ — On-site guidance ○ ○ Sample recovery — ○ Schedule the next follow-up visit ○ — Front desk check-out ○ ○

[0150] *Note: “○” indicates implementation, “—” indicates non-implementation.

[0151] 4.2 Detection Indicators and Instruments

[0152] Table 4 Detection Indicators and Instruments

[0153] Indicator Name Measuring instruments Test area Skin stratum corneum moisture content Multi-probe skin efficacy tester Facial area Transepidermal water loss rate Skin moisture loss tester Facial area EI value (facial skin hemoglobin index EI) Multifunctional 3D Skin Imaging Analyzer Facial area Adverse reaction record Clinical evaluation by a dermatologist Facial area Questionnaire Subject self-assessment Facial area

[0154] 4.3 Result Evaluation

[0155] If at least two parameters (including one main parameter) show significant differences at any follow-up visit point after product use compared with before use, it indicates that the test sample has a repair effect; otherwise, the test sample does not have a repair effect. At any time point, if the agreement rate of the research questions directly related to the research efficacy reaches over 80.00%, it is considered that the product has the research efficacy; otherwise, it does not have the research efficacy.

[0156] 4.4 Data Analysis

[0157] (1) Descriptive statistics: Calculate the mean, standard deviation, maximum value, minimum value, median, and improvement rate of each skin parameter at each time point.

[0158] (2) Normal distribution test: Conduct a normal distribution test on the above means. If the asymptotic significance (two-tailed) value of the normality test > 0.05, then this series of data follows a normal distribution.

[0159] (3) Difference analysis: Conduct a difference analysis on the above means. When both sets of data are normally distributed, use a paired T-test to analyze the differences between the two sets of data; when the two sets of data are not both normally distributed, use a relevant rank sum test to analyze the differences between the two sets of data.

[0160] (4) Judgment criteria: P > 0.05 represents no statistical difference between the two sets of data, denoted by "n.s."; 0.01 < P < 0.05 represents statistical significance, denoted by "*"; 0.001 < P < 0.01 represents significant difference, denoted by "**"; P < 0.001 represents extremely significant difference, denoted by "***".

[0161] 5. Test Results

[0162] 5.1 Subject Information

[0163] Table 5 Total Subject Information

[0164] Number of participants Valid number of people Minimum age Maximum age Average age numerical values 30 30 30 55 45.07

[0165] Table 6 Specific Subject Information

[0166]

[0167]

[0168] Note: Reasons not included in the statistics were loss to follow-up / failure to visit on time / failure to meet the inclusion criteria / failure to meet the exclusion criteria. 5.2 Instrument test results and statistical analysis results

[0169] 5.2.1 Skin moisture loss tester - Trans-epidermal water loss rate of the skin

[0170] Table 7 Descriptive statistical results and analysis of the test results of the trans-epidermal water loss rate of the skin

[0171]

[0172] All data are expressed as mean ± standard deviation (X±s).

[0173] a: The improvement rate is the improvement rate relative to before use, and the calculation formula is as follows:

[0174] Improvement rate of skin TEWL after using the product for t (D)

[0175] In the formula: D0 ---- Mean value of skin parameters of the effective number of people before using the product in the test area;

[0176] Dt ---- Mean value of skin parameters of the effective number of people after using the product in the test area.

[0177] Comparison chart of the basic value D0 and the test value D14 of the skin stratum corneum moisture content is as Figure 1 shown.

[0178] Result interpretation:

[0179] After continuously using the test product for 14 days, there was a significant difference (0.001 < P < 0.01) in the skin stratum corneum moisture content of the subjects compared with the basic value of the skin stratum corneum moisture content, and the improvement rate was 20.87%.

[0180] Test value: The larger the skin stratum corneum moisture content, the better, indicating that the moisturizing effect of the test product is better.

[0181] 5.2.3 Multifunctional 3D skin imaging analyzer - EI value

[0182] Table 8 Descriptive statistical results and analysis of the test results of EI value

[0183]

[0184] All data are expressed as mean ± standard deviation (X±s).

[0185] a: The improvement rate is the improvement rate relative to before use, and the calculation formula is as follows:

[0186] Improvement rate of skin EI value after using the product for t (D)

[0187] Where: D0----mean skin parameters of the effective number of test subjects before product application;

[0188] Dt----The average skin parameters of the effective number of people after the product was used in the test area.

[0189] The comparison chart of the baseline EI value D0 and the test value D14 is shown below. Figure 2 As shown.

[0190] Interpretation of results:

[0191] After 14 days of continuous use of the test product, there was no statistically significant difference in the EI value of the subjects compared with the baseline EI value (P>0.05), and the improvement rate was 1.18%.

[0192] Test value: The lower the EI value (facial skin hemoglobin index EI), the better, indicating that the product is more effective in relieving skin redness.

[0193] 5.3 Subject Evaluation Results

[0194] A total of 30 participants evaluated their satisfaction with the product after using it, and evaluated the product's effectiveness on day 14.

[0195] The user satisfaction evaluation results are shown in the table below: Scoring criteria (5 points): 1 point: Unsatisfied, 2 points: Somewhat dissatisfied, 3 points: Neutral, 4 points: Satisfied, 5 points: Very satisfied; The number of valid people who selected "Satisfied" is counted if the score is ≥3 points; Satisfaction rate = Number of valid people who selected "Satisfied" ÷ Number of valid participants in the test × 100%.

[0196] The product effectiveness evaluation results are shown in the table below: Scoring criteria (4 points): 0 points: no improvement, 1 point: slight improvement, 2 points: moderate improvement, 3 points: significant improvement; Statistical percentage = number of people who agree that the product has an improvement effect ÷ number of valid participants in the test × 100%.

[0197] Table 9

[0198]

[0199] The user satisfaction evaluation results of the Gastrodia elata sensitive skin soothing and repairing composition are as follows: Figure 3 As shown in the bar chart, the product effectiveness evaluation results for subject D14 are as follows: Figure 4 As shown.

[0200] Interpretation of results:

[0201] I. The results of the user satisfaction evaluation of the tested product by 30 participants showed:

[0202] (1) 90.00% of the subjects were satisfied with the product's odor evaluation during product use;

[0203] (2) 100.00% of the subjects were satisfied with the ease with which the product could be applied evenly during use;

[0204] (3) 100.00% of the subjects were satisfied with the product's permeability and absorbency during use;

[0205] (4) 100.00% of the subjects were satisfied with the moisturizing effect of the product during use;

[0206] (5) 96.67% of the subjects were satisfied with the comfort (non-irritation) of the skin when using the product;

[0207] (6) 100.00% of the subjects expressed satisfaction with the product's comfort, breathability, lack of stuffiness, oiliness, stickiness, and residue after use. II. 30 subjects evaluated the product's effectiveness after 14 days of use:

[0208] (1) 100.00% of the subjects felt that their dry skin had improved;

[0209] (2) 100.00% of the subjects believed that skin tolerance had improved;

[0210] (3) 100.00% of the subjects felt that their rough skin had improved;

[0211] (4) 100.00% of the subjects felt that skin redness had improved;

[0212] (5) 100.00% of the subjects believed that their skin had improved overall.

[0213] 6. Consumer Questionnaire Survey

[0214] Table 10

[0215]

[0216] Interpretation of Results

[0217] The results of self-assessment by 30 participants on day 14 using a self-report questionnaire showed that:

[0218] (1) 100.00% of the subjects believed that the product was mild and non-irritating;

[0219] (2) 100.00% of the subjects believed that the product was easily absorbed and not sticky;

[0220] (3) 100.00% of the subjects believed that the product improved dry skin;

[0221] (4) 100.00% of the subjects believed that the product improved skin flushing and tightness;

[0222] (5) 100.00% of the subjects believed that the product improved skin roughness;

[0223] (6) 100.00% of the subjects believed that the product improved skin sensitivity and discomfort;

[0224] (7) 100.00% of the subjects believed that their skin had no discomfort after using the product;

[0225] (8) 100.00% of the subjects were willing to buy this product.

[0226] 7. Adverse reaction records

[0227] There were no adverse reactions among the subjects in this trial.

[0228] Note: Adverse reactions were based on the grading standard of skin adverse reactions in human trial tests stipulated in the "Technical Specifications for Cosmetics Safety (2015 Edition)".

[0229] 8. Test conclusions

[0230] The results of instrument detection and evaluation showed that:

[0231] After continuously using the test product for 14 days, the transepidermal water loss rate of the subjects' skin was statistically significant compared with the transepidermal water loss rate of the baseline value (0.01 < P < 0.05), and the improvement rate was 8.56%.

[0232] After continuously using the test product for 14 days, the water content of the stratum corneum of the subjects' skin was significantly different compared with the water content of the stratum corneum of the baseline value (0.001 < P < 0.01), and the improvement rate was 20.87%.

[0233] After continuously using the test product for 14 days, there was no statistical difference in the EI value of the subjects compared with the EI value of the baseline value (P > 0.05), and the improvement rate was 1.18%.

[0234] Examples of effective subject effects are Figure 5 as shown.

[0235] The self-evaluation results of the subjects showed that:

[0236] I. The evaluation results of the satisfaction of 30 subjects with the usability of the test product showed that:

[0237] (1) 90.00% of the subjects were satisfied with the product smell during use;

[0238] (2) 100.00% of the subjects were satisfied with the ease of even application of the product during use;

[0239] (3) 100.00% of the subjects were satisfied with the product's permeability and absorbency during use;

[0240] (4) 100.00% of the subjects were satisfied with the moisturizing effect of the product during use;

[0241] (5) 96.67% of the subjects were satisfied with the comfort (non-irritation) of the skin when using the product;

[0242] (6) 100.00% of the subjects expressed satisfaction with the product's comfort, breathability, non-suffocating, non-greasy, non-sticky, and residue-free feel after use.

[0243] II. The efficacy of the experimental product was evaluated by 30 participants after 14 days of use:

[0244] (1) 100.00% of the subjects felt that their dry skin had improved;

[0245] (2) 100.00% of the subjects believed that skin tolerance had improved;

[0246] (3) 100.00% of the subjects felt that their rough skin had improved;

[0247] (4) 100.00% of the subjects felt that skin redness had improved;

[0248] (5) 100.00% of the subjects believed that their skin had improved overall.

[0249] III. The results of self-assessment by 30 participants on day 14 using a self-assessment questionnaire showed that:

[0250] (1) 100.00% of the subjects believed that the product was mild and non-irritating;

[0251] (2) 100.00% of the subjects believed that the product was easily absorbed and not sticky;

[0252] (3) 100.00% of the subjects believed that the product improved dry skin;

[0253] (4) 100.00% of the subjects believed that the product improved skin redness and tightness;

[0254] (5) 100.00% of the subjects believed that the product improved rough skin;

[0255] (6) 100.00% of the subjects believed that the product improved their skin sensitivity and discomfort;

[0256] (7) 100.00% of the subjects felt no discomfort on their skin after using the product;

[0257] (8) 100.00% of the subjects were willing to purchase this product.

[0258] In summary, the instrument test results show that the tested product has a repairing effect after 14 days of continuous use; the consumer questionnaire survey results show that 100.00% of the subjects agreed that the tested product is gentle and non-irritating, 100.00% agreed that the tested product improves skin redness and tightness, 100.00% agreed that the tested product improves skin sensitivity and discomfort, and 100.00% agreed that there was no discomfort after using the product. This indicates that the tested product has a soothing, gentle, and non-irritating effect, and is suitable for sensitive skin.

[0259] Experimental Example 2

[0260] In this experimental example, the physicochemical properties of the Gastrodia elata sensitive skin soothing and repairing composition prepared in Example 1 were tested, and the test results are shown in the table below:

[0261] Table 11

[0262]

[0263] The results showed that the Gastrodia elata sensitive skin soothing and repairing composition of the present invention met the testing standards.

[0264] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-described technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A soothing and repairing composition for sensitive skin made from Gastrodia elata, characterized in that, Including the following components by mass percentage: The skin protectant comprises Gastrodia elata extract and skin protectant 1, wherein the content of Gastrodia elata extract is 0.15%-0.25% of the total mass of the composition; and the skin protectant 1 comprises Bifida ferment filtrate, 1,2-hexanediol and p-hydroxyacetophenone, wherein the content is 74%-76% of the total mass of the composition.

2. The Gastrodia elata sensitive skin soothing and repairing composition according to claim 1, characterized in that, The skin protectant also includes: Skin protectant 2, comprising tea water, dipropylene glycol, 1,2-hexanediol and p-hydroxyacetophenone, in an amount of 11.5%-12.5% ​​of the total mass of the composition; Skin protectant 3 comprises lactobacillus / soy milk fermentation product filtrate, butylene glycol, 1,2-pentanediol and water, in an amount of 1.8%-2.2% of the total mass of the composition; Skin protectant 4 comprises glycerin, 1,2-hexanediol, 1,2-pentanediol, β-glucan, and water, in an amount of 0.8%-1.2% of the total mass of the composition.

3. The Gastrodia elata sensitive skin soothing and repairing composition according to claim 1 or 2, characterized in that, The skin protectant also includes: Skin protectant 5 comprises Dendrobium nobile extract, Quinoa seed extract, Giant kelp extract, 1,3-propanediol and water, in an amount of 0.45%-0.55% of the total mass of the composition; Skin protectant 6 comprises Sophora flavescens root extract, Salvia miltiorrhiza root extract, Andrographis paniculata leaf extract, 1,3-propanediol and water, in an amount of 0.45%-0.55% of the total mass of the composition; Skin protectant 7 comprises glycerin, caprylic / capric triglyceride, hydrogenated lecithin, phytosterol / octyldodecyl lauroyl glutamate, ceramide NP, sodium hyaluronate, and water, in an amount of 0.25%-0.35% of the total mass of the composition.

4. The Gastrodia elata sensitive skin soothing and repairing composition according to any one of claims 1-3, characterized in that, The skin protectant also includes: Skin protectant 8, comprising dipotassium glycyrrhizate, at a content of 0.04%-0.06% of the total mass of the composition; Skin protectant 9, comprising Coptis chinensis root extract and water, at a content of 0.04%-0.05% of the total mass of the composition; Skin protectant 10, comprising patchouli leaf extract and octyldodecanol, in an amount of 0.005%-0.015% of the total mass of the composition.

5. The Gastrodia elata sensitive skin soothing and repairing composition according to any one of claims 1-4, characterized in that, The skin protectant also includes: Skin protectant 11, comprising rosewood oil, in an amount of 0.005%-0.007% of the total mass of the composition; Skin protectant 12 comprises hydrolyzed soybean extract, gallnut extract, myrothamnus flabellifolia leaf / stem extract, tea extract, betaine, mandelic acid, butylene glycol, and water, in an amount of 0.003%-0.005% of the total mass of the composition; Skin protectant 13, comprising cocoa extract, in an amount of 0.0005%-0.0015% of the total mass of the composition.

6. The Gastrodia elata sensitive skin soothing and repairing composition according to any one of claims 1-5, characterized in that, The skin protectant also includes: Skin protectant 14, comprising birch sap, in an amount of 0.00005%-0.00015% of the total mass of the composition; Skin protectant 15, comprising methyl propylene glycol, hyaluronic acid, silanetriol, citric acid and water, in an amount of 0.00005%-0.00015% of the total mass of the composition; Skin protectant 16 comprises a soluble collagen cross-linked polymer, 1,2-hexanediol, p-hydroxyacetophenone, and water, in an amount of 0.00005%-0.00015% of the total mass of the composition; Skin protectant 17, comprising sea fennel callus culture filtrate, in an amount of 0.00005%-0.00015% of the total mass of the composition; Skin protectant 18 comprises citrus fruit extract, butylene glycol, and water, in an amount of 0.00005% to 0.00015% of the total mass of the composition.

7. The Gastrodia elata sensitive skin soothing and repairing composition according to any one of claims 1-6, characterized in that, The moisturizers include one or a combination of two or more of 1,3-propanediol, glycerin, allantoin, sodium hyaluronate, and alginic oligosaccharides. Preferably, the moisturizer is a combination of 1,3-propanediol, glycerin, allantoin, sodium hyaluronate, and alginic oligosaccharides.

8. The Gastrodia elata sensitive skin soothing and repairing composition according to any one of claims 1-7, characterized in that, The thickeners include one or a combination of two or more of sodium polyacrylate, polyacrylate crosspolymer-6, and carbomer; Preferably, the thickener is a combination of sodium polyacrylate, polyacrylate crosspolymer-6, and carbomer; Preferably, the solubilizer is PEG-40 hydrogenated castor oil, and the pH adjuster is tromethamine.

9. A method for preparing the Gastrodia elata sensitive skin soothing and repairing composition as described in any one of claims 1-8, characterized in that, include: (1) Add phase A raw material to the container in sequence, stir and heat to 70℃-75℃, homogenize at low speed, mix evenly, stir and keep warm. (2) Add phase B raw material, stir and cool to 60-65℃, stir for 15-20 minutes; (3) Cool down to 40-43℃, add the C phase raw material in sequence, stir until uniform, and continue to cool down; (4) Cool down to 40℃, add the uniformly dispersed D-phase raw material, stir evenly, and filter out the material after passing the test. The A-phase raw material includes a portion of skin protectant (including skin protectant 1), a portion of moisturizer, thickener, and pH adjuster; the B-phase raw material includes a portion of moisturizer and a portion of skin protectant; the C-phase raw material includes a portion of skin protectant (including Gastrodia elata extract) and a portion of moisturizer; and the D-phase raw material includes a solubilizer and a portion of skin protectant. Preferably, the A-phase raw materials include skin protectant 1, skin protectant 8, sodium polyacrylate, polyacrylate crosspolymer-6, carbomer, allantoin, sodium hyaluronate, and tromethamine. Phase B ingredients include skin protectant 15, 1,3-propanediol, and glycerin; Phase C ingredients include Gastrodia elata extract, skin protectants 2-7, 9-10, 12-14, 16-18, and algal oligosaccharides; Phase D raw materials include PEG-40 hydrogenated castor oil and skin protectant 11; Preferably, during the low-speed homogenization process, the rotation speed is 1000-1500 rpm, and the stirring time is 2-3 minutes; Preferably, in step (1), the mixture is stirred and kept warm for 10 minutes.

10. The use of the Gastrodia elata sensitive skin soothing and repairing composition as described in any one of claims 1-8 in the preparation of cosmetics; Preferably, the Gastrodia elata sensitive skin soothing and repairing composition is an essence.

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