Traditional Chinese medicine composition for treating high triglyceride phlegm-damp and turbid obstruction syndrome

Abstract

The invention discloses a traditional Chinese medicine composition for treating a high triglyceride phlegm-damp and turbid obstruction syndrome. Comprising the following raw material medicines in parts by weight: 18-25 parts of rhizoma alismatis, 14-20 parts of polygonum cuspidatum, 10-15 parts of lotus leaves, 10-15 parts of radix bupleuri, 14-20 parts of radix paeoniae alba, 14-20 parts of rhizoma atractylodis macrocephalae (fried), 14-20 parts of poria cocos, 14-20 parts of rhizoma coptidis (processed with ginger), 14-20 parts of gynostemma pentaphylla, 10-15 parts of herba epimedii, 30-40 parts of astragalus membranaceus, 21-30 parts of hawthorn, 14-20 parts of radix salviae miltiorrhizae (processed with wine), 2-4 parts of pseudo-ginseng (powder), 14-20 parts of oriental wormwood, 7-9 parts of fructus amomi, 10-15 parts of semen cassiae (fried), 4-6 parts of dried ginger and 3-5 parts of cinnamon. The traditional Chinese medicine composition disclosed by the invention is researched and developed on the basis of the etiology and pathogenesis of the high triglyceride phlegm-damp and turbid obstruction syndrome in traditional Chinese medicine diagnosis and treatment, and has an expected effect on treating the high triglyceride phlegm-damp and turbid obstruction syndrome.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome. Background Technology

[0002] Traditional Chinese medicine (TCM) categorizes hypertriglyceridemia under the concepts of "phlegm-dampness" and "blood turbidity," with its core pathogenesis being a deficiency of the root and an excess of the branch: dysfunction of the liver, spleen, and kidneys is the root (deficiency), while internal obstruction by phlegm-dampness and blood stasis is the branch (excess). TCM believes that the pathogenesis of hypertriglyceridemia lies in the blood, with its root cause in the spleen. It is attributed to spleen dysfunction, leading to the inability to separate clear and turbid substances, resulting in the transformation of essential substances into phlegm-dampness, which seeps into the blood vessels, manifesting as hyperlipidemia. Liver dysfunction affects bile excretion and lipid metabolism, leading to the accumulation of phlegm and blood stasis. Kidney yang deficiency weakens the body's ability to transform fluids, causing dampness to accumulate into phlegm-dampness, or kidney yin deficiency leads to the accumulation of fluids into phlegm due to deficiency fire, further exacerbating lipid deposition. Modern clinical practice primarily uses the differentiation of syndromes based on the internal organs, combined with pathological factors such as phlegm, dampness, and blood stasis, classifying hypertriglyceridemia into syndromes such as liver stagnation and spleen deficiency, phlegm-dampness obstruction, qi stagnation and blood stasis, liver and kidney yin deficiency, and spleen and kidney yang deficiency. Among them, phlegm-dampness obstruction syndrome is the most common, playing a crucial role in the progression of disease patterns. The main progression patterns of each syndrome are: spleen deficiency – dampness obstructing the middle jiao; dampness accumulating into phlegm – obstructing qi flow – poor blood circulation – phlegm and blood stasis intertwined; phlegm stagnation transforming into heat damaging yin – liver and kidney yin deficiency syndrome; phlegm obstructing the meridians and forming blood stasis – qi stagnation and blood stasis syndrome; phlegm and blood stasis damaging the kidney meridians – kidney yang deficiency and insufficient steaming; liver and kidney yin deficiency – prolonged yin failing to restrain yang – yin and yang deficiency. From the perspective of the progression patterns of hypertriglyceridemia, although the traditional Chinese medicine treatment of hypertriglyceridemia based on "differentiation and treatment according to syndrome" has individualized advantages, its passive nature of "using this medicine when there is a syndrome" and the limitations of "prescribing a single syndrome" are becoming increasingly prominent in the treatment of modern complex metabolic diseases. Further analysis reveals that Traditional Chinese Medicine (TCM) has the following main problems and shortcomings in treating hypertriglyceridemia with phlegm-dampness obstruction syndrome: This syndrome is a product of "treatment based on syndrome differentiation," meaning treatment only begins after the syndrome has developed, neglecting the dynamic progression of the syndrome and lacking measures to interrupt its progression. It adheres rigidly to the "syndrome-drug" correspondence, ignoring potential concurrent symptoms, thus affecting the overall therapeutic effect. To address the shortcomings and limitations of TCM's "treatment based on syndrome differentiation" approach to hypertriglyceridemia, the appropriate treatment strategy should be: shifting from "passive syndrome differentiation" to "actively interrupting the progression of syndromes," and expanding from "treatment only when a syndrome is present" to "prevention and interruption." This involves breaking the mechanical correspondence between "syndrome type and prescription" and establishing a four-in-one model of "syndrome differentiation – pathogenesis evolution – interruption of progression – overall treatment" to further improve the overall therapeutic effect of treating hypertriglyceridemia with phlegm-dampness obstruction syndrome. Summary of the Invention

[0003] In order to overcome the shortcomings of existing technologies, a traditional Chinese medicine composition for treating hypertriglyceridemia and phlegm-dampness obstruction syndrome is proposed to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention is implemented through the following technical solution: A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome comprises the following raw materials in parts by weight: Alisma plantago-aquatica 18-25 parts, Polygonum cuspidatum 14-20 parts, Nelumbo nucifera leaf 10-15 parts, Bupleurum chinense 10-15 parts, Paeonia lactiflora 14-20 parts, Atractylodes macrocephala (fried) 14-20 parts, Poria cocos 14-20 parts, Coptis chinensis (processed with ginger) 14-20 parts, Gynostemma pentaphyllum 14-20 parts, Epimedium brevicornu 10-15 parts, Astragalus membranaceus 30-40 parts, Crataegus pinnatifida 21-30 parts, Salvia miltiorrhiza (processed with wine) 14-20 parts, Panax notoginseng (powder) 2-4 parts, Artemisia capillaris 14-20 parts, Amomum villosum 7-9 parts, Cassia tora (fried) 10-15 parts, Zingiber officinale (dried) 4-6 parts, and Cinnamomum cassia 3-5 parts.

[0005] As a further technical solution of the present invention The raw materials include the following parts by weight: Alisma plantago-aquatica 18 parts, Polygonum cuspidatum 14 parts, Nelumbo nucifera leaf 10 parts, Bupleurum chinense 10 parts, Paeonia lactiflora 14 parts, Atractylodes macrocephala (fried) 14 parts, Poria cocos 14 parts, Coptis chinensis (ginger-processed) 14 parts, Gynostemma pentaphyllum 14 parts, Epimedium brevicornu 10 parts, Astragalus membranaceus 30 parts, Crataegus pinnatifida 21 parts, Salvia miltiorrhiza (wine-processed) 14 parts, Panax notoginseng (powder) 2 parts, Artemisia capillaris 14 parts, Amomum villosum 7 parts, Cassia tora (fried) 10 parts, dried ginger 4 parts, and cinnamon 3 parts.

[0006] As a further technical solution of the present invention, the raw materials include the following parts by weight: Alisma plantago-aquatica 25 parts, Polygonum cuspidatum 20 parts, Nelumbo nucifera leaf 15 parts, Bupleurum chinense 15 parts, Paeonia lactiflora 20 parts, Atractylodes macrocephala (fried) 20 parts, Poria cocos 20 parts, Coptis chinensis (ginger-processed) 20 parts, Gynostemma pentaphyllum 20 parts, Epimedium brevicornu 15 parts, Astragalus membranaceus 40 parts, Crataegus pinnatifida 30 parts, Salvia miltiorrhiza (wine-processed) 20 parts, Panax notoginseng (powder) 4 parts, Artemisia capillaris 20 parts, Amomum villosum 9 parts, Cassia tora (fried) 15 parts, dried ginger 6 parts, and cinnamon 5 parts.

[0007] The technical solution of the present invention is to provide a traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome. The composition is prepared by adding excipients required for formulation and following conventional methods for preparation.

[0008] Furthermore, the aforementioned traditional Chinese medicine preparations are decoctions, powders, ultrafine powders, pills, granules, tablets, capsules, or oral liquids.

[0009] The beneficial effects of this invention are: The pharmacological effects of each active pharmaceutical ingredient in this invention are as follows: Alisma plantago-aquatica, sweet and bland in taste, cold in nature; enters the kidney and bladder meridians. Main functions: promotes diuresis and eliminates dampness, clears heat and resolves phlegm.

[0010] Polygonum cuspidatum has a bitter taste and slightly cold properties; it enters the liver and gallbladder meridians. Its main functions are: dispelling wind and dampness, dispersing blood stasis and relieving pain, and relieving cough and resolving phlegm.

[0011] Lotus leaf is bitter in taste and neutral in nature; it enters the liver, spleen, and stomach meridians. Its main functions are: clearing summer heat and dampness, promoting the growth of clear yang, cooling the blood, and stopping bleeding.

[0012] Bupleurum root has a bitter taste and slightly cold properties; it enters the liver and gallbladder meridians. Its main functions are to harmonize the exterior and interior, soothe the liver and relieve depression, and raise yang energy.

[0013] White peony root has a bitter and sour taste, and is slightly cold in nature; it enters the liver and spleen meridians. Its main functions are: nourishing blood and regulating qi, soothing the liver and relieving pain, and calming liver yang.

[0014] Atractylodes macrocephala has a bitter and sweet taste, and is warm in nature; it enters the spleen and stomach meridians. Its main functions are to strengthen the spleen and replenish qi, and to dry dampness and promote diuresis.

[0015] Poria cocos is sweet and bland in taste, and neutral in nature; it enters the heart, lung, spleen, and kidney meridians. Its main functions are: promoting diuresis and eliminating dampness, strengthening the spleen and harmonizing the stomach, and calming the mind and soothing the nerves.

[0016] Coptis chinensis, bitter in taste and cold in nature; enters the heart, spleen, stomach, and gallbladder meridians. Main functions: clears heat and dries dampness, drains fire and detoxifies.

[0017] Gynostemma pentaphyllum has a bitter and slightly sweet taste, and is cool in nature; it enters the lung, spleen, and kidney meridians. Its main functions are: tonifying deficiency and replenishing qi, clearing heat and resolving phlegm, and reducing turbidity and lipids.

[0018] Epimedium, pungent and sweet in taste, warm in nature; enters the liver and kidney meridians. Main functions: tonifies kidney yang, strengthens tendons and bones, and dispels wind and dampness.

[0019] Astragalus membranaceus (Huang Qi) is sweet in taste and warm in nature; it enters the lung and spleen meridians. Its main functions are: tonifying qi and raising yang, consolidating the exterior and stopping sweating, and promoting diuresis and reducing swelling.

[0020] Hawthorn has a sour and sweet taste, and is slightly warm in nature; it enters the spleen, stomach, and liver meridians. Its main functions are to aid digestion, strengthen the stomach, promote qi circulation, and dispel blood stasis.

[0021] Salvia miltiorrhiza (danshen) has a bitter taste and slightly cold properties; it enters the heart and liver meridians. Its main functions are: promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, nourishing blood and calming the mind.

[0022] Panax notoginseng has a sweet and slightly bitter taste, and is warm in nature; it enters the liver and stomach meridians. Its main functions are to disperse blood stasis, stop bleeding, reduce swelling, and relieve pain.

[0023] Artemisia capillaris is bitter and pungent, and slightly cold in nature; it enters the liver, gallbladder, spleen, stomach, and bladder meridians. Its main functions are to clear damp-heat and relieve jaundice.

[0024] Amomum villosum has a pungent taste and warm properties; it enters the spleen, stomach, and kidney meridians. Its main functions are: to resolve dampness and stimulate appetite, warm the spleen and stop diarrhea, regulate qi and calm the fetus, and promote qi circulation and relieve chest congestion.

[0025] Cassia seed has a bitter, sweet, and salty taste, and is slightly cold in nature; it enters the liver, kidney, and large intestine meridians. Its main functions are: clearing the liver and improving eyesight, and moistening the intestines to relieve constipation.

[0026] Dried ginger is pungent and hot in nature; it enters the spleen, stomach, kidney, heart, and lung meridians. Its main functions are: warming the middle jiao (spleen and stomach) and dispelling cold, restoring yang and unblocking the meridians, and warming the lungs and resolving phlegm.

[0027] Cinnamon has a pungent and sweet taste, and is very hot in nature; it enters the kidney, spleen, heart, and liver meridians. Its main functions are: tonifying fire and assisting yang, dispelling cold and relieving pain, and warming the meridians and promoting blood circulation.

[0028] The pharmacological effects of the raw materials in the composition of this invention are as follows: Alisma plantago-aquatica inhibits intestinal cholesterol absorption and reduces the synthesis of triglycerides and very low-density lipoprotein. Polygonum cuspidatum promotes fatty acid oxidation. Nelumbo nucifera inhibits pancreatic lipase activity, reduces dietary fat breakdown and absorption, and inhibits fat production. Bupleurum chinense regulates bile acid metabolism and promotes cholesterol excretion. Paeonia lactiflora has anti-inflammatory and liver-protective effects. Atractylodes macrocephala enhances the intestinal mucosal barrier and reduces liver inflammation and lipid metabolism disorders caused by endotoxins entering the bloodstream. Poria cocos increases urinary lipid excretion, improves intestinal flora, and reduces endogenous lipid production. Coptis chinensis regulates intestinal flora bile acid metabolism and promotes fecal lipid excretion. Gynostemma pentaphyllum accelerates chylomicron decomposition and promotes triglyceride clearance. Epimedium brevicornu improves insulin resistance in adipose tissue. Astragalus membranaceus enhances insulin sensitivity and reduces free fatty acid release. Crataegus pinnatifida reduces cholesterol esterification. Salvia miltiorrhiza improves liver microcirculation and reduces lipid peroxidation damage. Panax notoginseng inhibits platelet aggregation and improves microcirculatory disorders secondary to hypertriglyceridemia. Artemisia capillaris promotes bile acid synthesis and excretion, reducing triglyceride accumulation in the liver. Amomum villosum promotes bile secretion, accelerates lipid emulsification, enhances gastrointestinal motility, and reduces lipid retention and absorption. Cassia seed reduces intestinal cholesterol absorption. Dried ginger promotes adrenaline secretion, increases basal metabolic rate, and accelerates lipid consumption. Cinnamon reduces the conversion of sugar into fat.

[0029] Furthermore, the pharmacological effects of each active ingredient in the composition of this invention align with the core pharmacological mechanisms of Western medicine in treating hypertriglyceridemia, as detailed below: Inhibition of lipid absorption and synthesis: Alisma plantago-aquatica, Nelumbo nucifera leaf, Cassia tora seed, Amomum villosum. Regulation of lipid decomposition and transport: Gynostemma pentaphyllum, Polygonum cuspidatum, Salvia miltiorrhiza, Crataegus pinnatifida. Promotion of lipid excretion and metabolism: Artemisia capillaris, Poria cocos, Coptis chinensis. Improvement of insulin resistance and glucose-lipid metabolism: Astragalus membranaceus, Epimedium brevicornu, Bupleurum chinense. Other auxiliary mechanisms: Paeonia lactiflora, Atractylodes macrocephala, Panax notoginseng, Zingiber officinale, Cinnamomum cassia.

[0030] The formulation of active pharmaceutical ingredients in this invention adheres to a drug selection and formulation approach that combines traditional Chinese medicine pharmacological mechanisms with modern Western medicine pharmacological mechanisms, prioritizing traditional Chinese medicine mechanisms and supplementing them with Western medicine mechanisms. This approach, which emphasizes the integration of traditional Chinese and Western medicine, the combination of disease and syndrome differentiation, and the compatibility of the pharmacological mechanisms of both, further enhances the accuracy and scientific basis of the drug formulation in this invention. The traditional Chinese and Western medicine pharmacological mechanisms of each active pharmaceutical ingredient in the composition of this invention are known or publicly disclosed.

[0031] The formulation (principal, assistant, adjuvant, and guide) of this invention and its pharmacological mechanisms in traditional Chinese medicine and Western medicine are as follows: The principal herbs (directly targeting phlegm and dampness to reduce turbidity) are: Alisma plantago-aquatica, Polygonum cuspidatum, and Nelumbo nucifera leaf. Alisma plantago-aquatica promotes diuresis and eliminates dampness, clears heat and eliminates phlegm, inhibits intestinal cholesterol absorption, and reduces the synthesis of triglycerides and very low-density lipoprotein. Polygonum cuspidatum dispels wind and dampness, relieves cough and eliminates phlegm, and promotes fatty acid oxidation. Nelumbo nucifera leaf clears summer heat and eliminates dampness, inhibits pancreatic lipase activity, reduces the decomposition and absorption of dietary fat, and inhibits fat production. Alisma plantago-aquatica eliminates dampness through urination, while Nelumbo nucifera leaf eliminates fat through defecation, forming a "two-way distribution" between urination and defecation. Polygonum cuspidatum clears blood stasis and heat, while Nelumbo nucifera leaf protects the intestinal barrier. Nelumbo nucifera leaf and Polygonum cuspidatum block the vicious cycle of "intestinal leakage leading to vascular inflammation." The innovation of the principal herb combination lies in breaking through the traditional single-pathway of "dampness-eliminating drugs" and innovating a combined Chinese and Western medicine model that addresses lipid turbidity through both "systemic circulation and intestinal circulation."

[0032] The following are the main ingredients (preventing dampness at its source): Bupleurum, White Peony Root, Atractylodes Macrocephala (fried), Poria, Coptis chinensis (ginger-processed), and Gynostemma pentaphyllum. The Liver-Soothing and Source-Cutting Group: Bupleurum soothes the liver and relieves stagnation, regulates bile acid metabolism, and promotes cholesterol excretion. White Peony Root softens the liver, nourishes Yin, and has anti-inflammatory and liver-protecting effects. The combination of Bupleurum and White Peony Root prevents "liver disease from spreading to the spleen." The Spleen-Strengthening and Dampness-Preventing Group: Atractylodes Macrocephala strengthens the spleen and dries dampness, enhances the intestinal mucosal barrier, and reduces liver inflammation and lipid metabolism disorders caused by endotoxins entering the bloodstream. Poria drains dampness, promotes urination, strengthens the spleen and harmonizes the middle Jiao, increases urinary lipid excretion, improves intestinal flora, and reduces endogenous lipid production. The Blood-Clearing and Heat-Preventing Group: Coptis chinensis clears heat and dries dampness, regulates intestinal flora and bile acid metabolism, and promotes fecal lipid excretion. Gynostemma pentaphyllum detoxifies and resolves phlegm, accelerates the decomposition of chylomicrons, and promotes triglyceride clearance. The innovative aspect of these main ingredients lies in: Gynostemma pentaphyllum detoxifies and resolves phlegm, accelerates the decomposition of chylomicrons in the liver, and promotes triglyceride clearance. Lotus leaves clear heat and dampness, reduce the breakdown and absorption of dietary fat, and inhibit fat production. When combined with lotus leaves, Gynostemma pentaphyllum forms a "hepato-intestinal dual-circulation lipid-lowering axis".

[0033] Adjuvant herbs (preventing progression, strengthening the body and protecting organs): Epimedium, Astragalus, Hawthorn, Salvia miltiorrhiza (processed with wine), Panax notoginseng (powder), Artemisia capillaris. Preventing damage to kidney yang: Epimedium warms the kidneys and assists yang, improving insulin resistance in adipose tissue. Astragalus tonifies qi and promotes diuresis, enhancing insulin sensitivity and reducing the release of free fatty acids. The combination of Epimedium and Astragalus blocks the progression of phlegm-dampness to spleen and kidney yang deficiency. Preventing blood stasis and obstruction: Hawthorn promotes digestion, strengthens the stomach, regulates qi and disperses blood stasis, reducing cholesterol esterification. Salvia miltiorrhiza invigorates blood and unblocks collaterals, improving liver microcirculation and reducing lipid peroxidation damage. Panax notoginseng disperses blood stasis and stops bleeding, inhibits platelet aggregation, and improves microcirculatory disorders secondary to hypertriglyceridemia. The combination of Hawthorn, Salvia miltiorrhiza, and Panax notoginseng prevents phlegm-blood stasis from damaging the collaterals. Artemisia capillaris clears damp heat, reduces jaundice, promotes bile acid synthesis and excretion, reduces triglyceride accumulation in the liver, and is combined with Gynostemma pentaphyllum to detoxify.

[0034] Guiding herbs (for harmonizing and guiding the flow of Qi): Amomum villosum, Cassia tora (fried), dried ginger, and cinnamon. Amomum villosum dispels dampness and promotes Qi circulation, stimulates bile secretion, accelerates lipid emulsification, enhances gastrointestinal motility, and reduces lipid retention and absorption. Cassia tora lubricates the intestines and promotes bowel movements, reducing intestinal cholesterol absorption. The combination of Amomum villosum and Cassia tora helps expel pathogenic factors from the lower burner. Dried ginger promotes adrenaline secretion, increases basal metabolic rate, and accelerates lipid consumption. Cinnamon reduces the conversion of sugar into fat. The combination of dried ginger and cinnamon warms the middle burner, dispels cold, and helps resolve phlegm and dampness.

[0035] The inventiveness of this invention is mainly reflected in: 1. Establishing a new treatment principle for the "three-level interruption" of the transmission of hypertriglyceridemia with phlegm-dampness obstruction. This invention breaks through the passive mode of "differentiated treatment based on type and symptoms" in the traditional treatment of hypertriglyceridemia with phlegm-dampness obstruction, and innovates the thinking of "treating phlegm but not transmission." It establishes a new treatment principle for the "three-level interruption" of the transmission of hypertriglyceridemia with phlegm-dampness obstruction, further expanding the new breakthroughs in the treatment of hypertriglyceridemia with phlegm-dampness obstruction based on the "prevention of disease" thought in the *Huangdi Neijing* and the theory of "ensuring the place not yet affected by evil" in the *Treatise on Warm Diseases* by physician Ye Tianshi. This is mainly reflected in the following: Preventing disease: The combination of Bupleurum, White Peony Root, Atractylodes Macrocephala, and Poria Cocos interrupts the chain of "liver stagnation transmitting to the spleen and generating dampness." Preventing disease progression: The combination of Coptis, Polygonum Cuspidatum, Salvia Miltiorrhiza, and Panax Notoginseng interrupts the chain of "dampness stagnation transforming into heat and blood stasis." Preventing damage from existing disease: The combination of Epimedium, Astragalus, Cinnamon, and Dried Ginger breaks the chain of "prolonged disease affecting the kidneys" (innovating the theory of "the kidney as the root of phlegm, treating phlegm from the kidneys," breaking the final transformation of phlegm-dampness syndrome into metabolic syndrome). 2. Constructing a new model for lipid metabolism in patients with high triglycerides and phlegm-dampness obstruction. First, it breaks through the traditional single path of "dampness-eliminating drugs" and innovates a dual-mode of lipid metabolism "systemic circulation-intestinal circulation" (combination of Alisma and Lotus Leaf; combination of Polygonum cuspidatum and Lotus Leaf). Second, it constructs a "liver-intestinal dual-circulation lipid-lowering axis" (combination of Gynostemma pentaphyllum and Lotus Leaf). Third, it achieves an innovative breakthrough from "lipid lowering" to "rebuilding the physiological balance of lipid metabolism." Bupleurum and Atractylodes macrocephala rebuild the homeostasis of liver and spleen lipid metabolism to prevent rebound, while Epimedium activates the kidney yang metabolic engine. Bupleurum in the upper burner promotes the flow of qi and blood, and helps the liver to excrete lipids; lotus leaf in the middle burner promotes the upward movement of clear qi and the downward movement of turbid qi; Alisma and Epimedium in the lower burner promote the vaporization of qi and blood, so that turbid lipids can be excreted through urine and feces, thereby achieving the "three burners separate elimination" of lipid turbidity.

[0036] The individual pharmacological effects of each active pharmaceutical ingredient in the composition of this invention have been clearly recorded in the authoritative document, the Chinese Pharmacopoeia. The formulation and compatibility are all conventional, with clear synergistic effects and uses, directly related to the known uses of each active pharmaceutical ingredient. Therefore, the formulation of this invention is based on the certainty of the known efficacy of the active pharmaceutical ingredients and the synergistic effects of the combination, thus conforming to the theory and principles of traditional Chinese medicine formula compatibility. Simultaneously, the pharmacological effects of each active pharmaceutical ingredient in the composition of this invention are known or publicly disclosed in Western medicine. The high degree of compatibility between the pharmacological mechanisms of traditional Chinese medicine and Western medicine helps those skilled in the art to better analyze and understand the regularity and logic of the principles, methods, formulas, and drugs of this invention.

[0037] Furthermore, those skilled in the art, based on the existing technology's disclosure of the etiology, pathogenesis, treatment principles, and the pharmacological mechanisms of each raw material in this formula (both traditional Chinese medicine and Western medicine), as well as the certainty of synergistic effects of the combination, are able to predict that this invention will have the expected effect of treating hypertriglycerid phlegm-dampness obstruction syndrome. Specific Implementation

[0038] Example 1 A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome comprises the following raw materials in parts by weight: Alisma plantago-aquatica 18-25 parts, Polygonum cuspidatum 14-20 parts, Nelumbo nucifera leaf 10-15 parts, Bupleurum chinense 10-15 parts, Paeonia lactiflora 14-20 parts, Atractylodes macrocephala (fried) 14-20 parts, Poria cocos 14-20 parts, Coptis chinensis (processed with ginger) 14-20 parts, Gynostemma pentaphyllum 14-20 parts, Epimedium brevicornu 10-15 parts, Astragalus membranaceus 30-40 parts, Crataegus pinnatifida 21-30 parts, Salvia miltiorrhiza (processed with wine) 14-20 parts, Panax notoginseng (powder) 2-4 parts, Artemisia capillaris 14-20 parts, Amomum villosum 7-9 parts, Cassia tora (fried) 10-15 parts, Zingiber officinale (dried) 4-6 parts, and Cinnamomum cassia 3-5 parts.

[0039] Example 2 A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome comprises the following raw materials in parts by weight: Alisma plantago-aquatica 18 parts, Polygonum cuspidatum 14 parts, Nelumbo nucifera leaf 10 parts, Bupleurum chinense 10 parts, Paeonia lactiflora 14 parts, Atractylodes macrocephala (fried) 14 parts, Poria cocos 14 parts, Coptis chinensis (ginger-processed) 14 parts, Gynostemma pentaphyllum 14 parts, Epimedium brevicornu 10 parts, Astragalus membranaceus 30 parts, Crataegus pinnatifida 21 parts, Salvia miltiorrhiza (wine-processed) 14 parts, Panax notoginseng (powder) 2 parts, Artemisia capillaris 14 parts, Amomum villosum 7 parts, Cassia tora (fried) 10 parts, dried ginger 4 parts, and cinnamon 3 parts.

[0040] Example 3 A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome comprises the following raw materials in parts by weight: Alisma plantago-aquatica 25 parts, Polygonum cuspidatum 20 parts, Nelumbo nucifera leaf 15 parts, Bupleurum chinense 15 parts, Paeonia lactiflora 20 parts, Atractylodes macrocephala (fried) 20 parts, Poria cocos 20 parts, Coptis chinensis (ginger-processed) 20 parts, Gynostemma pentaphyllum 20 parts, Epimedium brevicornu 15 parts, Astragalus membranaceus 40 parts, Crataegus pinnatifida 30 parts, Salvia miltiorrhiza (wine-processed) 20 parts, Panax notoginseng (powder) 4 parts, Artemisia capillaris 20 parts, Amomum villosum 9 parts, Cassia tora (fried) 15 parts, Zingiber officinale (dried) 6 parts, and Cinnamomum cassia 5 parts.

[0041] Example 4 A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome comprises the following raw materials in parts by weight: Alisma plantago-aquatica 22 parts, Polygonum cuspidatum 17 parts, Nelumbo nucifera leaf 13 parts, Bupleurum chinense 12 parts, Paeonia lactiflora 17 parts, Atractylodes macrocephala (fried) 17 parts, Poria cocos 27 parts, Coptis chinensis (ginger-processed) 17 parts, Gynostemma pentaphyllum 17 parts, Epimedium brevicornu 12 parts, Astragalus membranaceus 35 parts, Crataegus pinnatifida 25 parts, Salvia miltiorrhiza (wine-processed) 17 parts, Panax notoginseng (powder) 3 parts, Artemisia capillaris 17 parts, Amomum villosum 8 parts, Cassia tora (fried) 13 parts, Zingiber officinale (dried) 5 parts, and Cinnamomum cassia 4 parts.

[0042] All features described in the specification and appended claims, whether individually or in any combination thereof, are essential features of this invention.

[0043] Although embodiments of the present invention have been shown and described above, it will be apparent to those skilled in the art that the present invention is not limited to the details of the above embodiments. The above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions, variations, deletions of features, additions of features, and recombination of features to the above embodiments to form technical solutions without departing from the principles and rules of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the innovative principles of the present invention still fall within the scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome, characterized in that, The raw materials include the following parts by weight: Alisma plantago-aquatica 18-25 parts, Polygonum cuspidatum 14-20 parts, Nelumbo nucifera leaf 10-15 parts, Bupleurum chinense 10-15 parts, Paeonia lactiflora 14-20 parts, Atractylodes macrocephala (fried) 14-20 parts, Poria cocos 14-20 parts, Coptis chinensis (processed with ginger) 14-20 parts, Gynostemma pentaphyllum 14-20 parts, Epimedium brevicornu 10-15 parts, Astragalus membranaceus 30-40 parts, Crataegus pinnatifida 21-30 parts, Salvia miltiorrhiza (processed with wine) 14-20 parts, Panax notoginseng (powder) 2-4 parts, Artemisia capillaris 14-20 parts, Amomum villosum 7-9 parts, Cassia tora (fried) 10-15 parts, Zingiber officinale (dried) 4-6 parts, and Cinnamomum cassia 3-5 parts.

2. The traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome according to claim 1, characterized in that, The raw materials and their weight parts are as follows: Alisma plantago-aquatica 18 parts, Polygonum cuspidatum 14 parts, Nelumbo nucifera leaf 10 parts, Bupleurum chinense 10 parts, Paeonia lactiflora 14 parts, Atractylodes macrocephala (fried) 14 parts, Poria cocos 14 parts, Coptis chinensis (ginger-processed) 14 parts, Gynostemma pentaphyllum 14 parts, Epimedium brevicornu 10 parts, Astragalus membranaceus 30 parts, Crataegus pinnatifida 21 parts, Salvia miltiorrhiza (wine-processed) 14 parts, Panax notoginseng (powder) 2 parts, Artemisia capillaris 14 parts, Amomum villosum 7 parts, Cassia tora (fried) 10 parts, dried ginger 4 parts, and cinnamon 3 parts.

3. The traditional Chinese medicine composition for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome according to claim 1, characterized in that, The raw materials and their weight parts are as follows: Alisma plantago-aquatica 25 parts, Polygonum cuspidatum 20 parts, Nelumbo nucifera leaf 15 parts, Bupleurum chinense 15 parts, Paeonia lactiflora 20 parts, Atractylodes macrocephala (fried) 20 parts, Poria cocos 20 parts, Coptis chinensis (ginger-processed) 20 parts, Gynostemma pentaphyllum 20 parts, Epimedium brevicornu 15 parts, Astragalus membranaceus 40 parts, Crataegus pinnatifida 30 parts, Salvia miltiorrhiza (wine-processed) 20 parts, Panax notoginseng (powder) 4 parts, Artemisia capillaris 20 parts, Amomum villosum 9 parts, Cassia tora (fried) 15 parts, Zingiber officinale (dried) 6 parts, and Cinnamomum cassia 5 parts.

4. A traditional Chinese medicine preparation for treating hypertriglyceridemia with phlegm-dampness obstruction syndrome, characterized in that, In the traditional Chinese medicine composition according to claims 1-3, excipients required for formulation are added, and the composition is prepared according to conventional methods for preparing formulations.

5. The traditional Chinese medicine preparation according to claim 4, characterized in that, The compound preparation is a decoction, powder, ultrafine powder, pill, granule, tablet, capsule or oral liquid.