Anti-aging capsule compounded by PQQ and mitochondrial nutrients

Abstract

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

Description

TECHNICAL FIELD

[0001] The application relates to an anti-aging capsule containing PQQ (pyrroloquinoline quinone) as a core and a plurality of mitochondrial function nutrients, and belongs to the technical field of nutritional health foods, in particular to an anti-aging capsule prepared by synergistically compounding a plurality of mitochondrial nutrients in a scientific proportion, supplemented with high-purity raw materials and a sustained-release dosage form, so that energy metabolism activation and antioxidant synergistic intervention are realized, thereby achieving multi-target regulation of mitochondrial function and systematic anti-aging. BACKGROUND

[0002] Aging is a systematic process caused by multiple factors, and mitochondrial function decline is considered to be one of the key mechanisms, which is manifested as a decrease in energy metabolism efficiency, accumulation of free radicals and aggravation of cell damage. In recent years, PQQ (pyrroloquinoline quinone) has attracted attention due to its promotion of mitochondrial generation and enhancement of antioxidant capacity, and mitochondrial nutrients such as coenzyme Q10, L-carnitine, alpha-lipoic acid and nicotinamide mononucleotide (NMN) are also widely used to improve cell activity and delay aging. At present, there are some anti-aging capsule products on the market with PQQ or NMN as the core component, but most of them have the following shortcomings: first, most of them are composed of single or two active ingredients, lack of systematic and multi-target functional synergistic design, and the action path is limited; second, the formula proportion lacks scientific demonstration, and the absorption rate of some components is low and the bioavailability is insufficient, which affects the actual efficacy of the product; third, some products often contain artificial additives or unsuitable ingredients, which are not conducive to the long-term safe use of special groups of people.

[0003] Publication No. CN114901083A discloses a composition containing sesamin and PQQ, which can be used to improve mitochondrial function and / or energy production capacity of mitochondria, inhibit the decrease thereof or maintain the mitochondrial function and / or energy production capacity of mitochondria, and has high safety, is easy to take and can be continuously taken without worrying about side effects. In addition, the application also provides a method for improving mitochondrial function and / or energy production capacity of mitochondria, inhibiting the decrease thereof or maintaining the mitochondrial function and / or energy production capacity of mitochondria. The application relates to a composition containing one or more sesamin and pyrroloquinoline quinone (PQQ) or a salt thereof. However, the above-mentioned composition does not make targeted design on the absorption efficiency, stability or gastrointestinal degradation of active ingredients in the human body, which may result in low actual utilization rate of PQQ or sesamin in the body, affecting the function, and does not make clear explanation on the adaptation of the product to the population, safety limit or risk of use by special groups of people, and the composition may still contain auxiliary materials or allergens which are not friendly to patients with diabetes, hypertension and lactose intolerance. SUMMARY

[0004] In order to improve the above situation, the PQQ and mitochondrial nutrient compounded anti-aging capsule provides a kind of anti-aging capsule through a variety of mitochondrial nutrients in scientific proportion, and is assisted by high-purity raw materials and sustained-release dosage form, realizes energy metabolism activation and antioxidant synergistic intervention, so as to achieve the anti-aging capsule through multi-target regulation of mitochondrial function and systematic delay of aging.

[0005] The PQQ and mitochondrial nutrient compounded anti-aging capsule is realized as follows: the PQQ and mitochondrial nutrient compounded anti-aging capsule, characterized in that, the following ingredients are included by weight: pyrroloquinoline quinone disodium salt (PQQ) 1-20 mg, coenzyme Q10 20-100 mg, L-carnitine tartrate 50-200 mg, alpha-lipoic acid 10-100 mg, nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) 50-300 mg, selenoprotein or organic selenium yeast 10-50 μg, capsule carrier including gelatin or plant source capsule shell 100 mg, microcrystalline cellulose 180 mg, magnesium stearate 5 mg, silicon dioxide 5 mg, Preferably, the PQQ is PQQ disodium salt, the purity is greater than or equal to 98%, and the source is a biological fermentation extract, Preferably, the coenzyme Q10 is a micron grade crystalline powder, and the particle size is controlled within 10-50 μm, Preferably, the L-carnitine tartrate has a purity greater than or equal to 98%, Preferably, the alpha-lipoic acid adopts optically pure alpha-R-lipoic acid, Preferably, the nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) has a purity greater than or equal to 99%, and is stored stably in the form of freeze-dried powder, Preferably, the selenoprotein or selenium-rich yeast powder has a selenium content controlled within the range of 30-200 μg / 100g, Preferably, the anti-aging capsule further adds one or more of the following synergistic antioxidant ingredients: vitamin E (alpha-tocopherol) 10-30 mg, vitamin C (ascorbic acid) 50-100 mg, zinc (such as zinc gluconate) 5-15 mg, black pepper extract (piperine) 1-5 mg, Preferably, all ingredients in the anti-aging capsule do not add artificial preservatives, artificial colors, sugar or dairy products. Beneficial effects

[0006] I. Multi-target synergistic effect, significantly enhancing the anti-aging effect.

[0007] II. Each active ingredient is selected from high-purity, high-stability, high-quality sources, and the dose is scientific and the ratio is reasonable.

[0008] III. High safety, wide adaptation to the population. DETAILED DESCRIPTION Example 1

[0009] The anti-aging capsule of PQQ and mitochondrial nutrients of the application is realized as follows: the anti-aging capsule of PQQ and mitochondrial nutrients of the application is characterized in that the following components are included by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), 10-50 μg of selenoprotein or organic selenium yeast, 100 mg of capsule carrier including gelatin or plant source capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate, 5 mg of silicon dioxide, Preferably, the components are composed in the following complexing ratio: PQQ: coenzyme Q10: L-carnitine: alpha-lipoic acid: NMN = 1:5:10:2:10, Preferably, the PQQ is PQQ disodium salt, with a purity of ≥98%, and is extracted from biological fermentation, Preferably, the coenzyme Q10 is a micron grade crystalline powder, with a particle size controlled within 10-50 μm, Preferably, the L-carnitine tartrate has a purity of ≥98%, Preferably, the alpha-lipoic acid is optically pure alpha-R-lipoic acid, Preferably, the nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) has a purity of ≥99%, and is stored stably in the form of freeze-dried powder, Preferably, the selenoprotein or selenium-rich yeast powder has a selenium content controlled within 30-200 μg / 100g, Preferably, the anti-aging capsule further adds one or more of the following synergistic antioxidant components: 10-30 mg of vitamin E (alpha-tocopherol), 50-100 mg of vitamin C (ascorbic acid), 5-15 mg of zinc (such as zinc gluconate), 1-5 mg of black pepper extract (piperine), Preferably, all components in the capsule do not add artificial preservatives, artificial colors, sugar or dairy products; Example 2

[0010] The difference between this embodiment and embodiment 1 is that the content of each anti-aging capsule is as follows: PQQ disodium salt 5 mg, coenzyme Q10 25 mg, L-carnitine tartrate 50 mg, alpha-lipoic acid 10 mg, NMN 50 mg, selenium-rich yeast 20 μg, and microcrystalline cellulose 200 mg, magnesium stearate 1 mg, and silicon dioxide 1 mg are added into a gelatin hollow capsule shell, 1-2 capsules are taken per day, and after continuous taking for 8 weeks, the serum SOD activity can be significantly improved and the MDA level can be reduced; Embodiment 3

[0011] The difference between this embodiment and embodiment 1 is that 20 mg of vitamin E and 3 mg of black pepper extract are added to the anti-aging capsule to enhance the antioxidant capacity and improve the absorption efficiency. The design of the synergistic combination of PQQ and mitochondrial nutrients can intervene in the mitochondrial function decline process through multiple targets, activate energy metabolism, regenerate NAD⁺, and remove free radicals in multiple links, thereby significantly improving the comprehensive anti-aging efficiency. The ratio design of PQQ: coenzyme Q10: L-carnitine: alpha-lipoic acid: NMN = 1:5:10:2:10 can ensure the effective dose while achieving scientific synergy between ingredients, avoiding dose overlap or imbalance, and improving the biological activity and metabolic coordination of the overall formula. The micron-sized crystalline powder of coenzyme Q10 has a particle size controlled within 10-50 μm, which can significantly improve the dispersibility and dissolution rate of coenzyme Q10 in the intestinal tract, improve its absorption efficiency in the human body, and thereby enhance its biological activity in mitochondrial energy metabolism and antioxidant reactions. The design of the capsule dosage form with microcrystalline cellulose can achieve sustained release and targeted release in the gastrointestinal environment, reduce the degradation of ingredients, and improve the absorption efficiency of key nutrients in the small intestine. The optional design of the synergistic antioxidant ingredients (vitamin E, C, zinc, and black pepper extract) can enhance the antioxidant efficiency of the basic nutritional components, promote absorption, and meet the needs of different populations for personalized nutritional supplements. The formulation design without adding artificial preservatives, pigments, sugar, and dairy products can maximize the adaptability of the product, making it suitable for long-term consumption by diabetic populations, lactose-intolerant populations, and consumers who are sensitive to additives. Through the synergistic combination of various mitochondrial nutrients in a scientific ratio, supplemented by high-purity raw materials and sustained-release dosage forms, energy metabolism activation and antioxidant synergistic intervention can be achieved, thereby achieving the goal of regulating mitochondrial function through multiple targets and systematically delaying aging.

[0012] It should be noted that unless otherwise explicitly specified and limited, the terms "placed", "connected", and "linked" should be interpreted broadly, for example, can be fixed connection modes such as folding connection, rivet connection, pin connection, bonding connection, and welding connection, or can be detachable connection modes such as threaded connection, buckle connection, and hinge connection, or integral connection, or electrical connection, or direct connection, or indirect connection through an intermediate medium, or internal communication of two elements. For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0013] It should be further pointed out that in the description of the above specific embodiments, only the differences with other embodiments are described for simplicity and clarity, but those skilled in the art should know that the above specific embodiments themselves are also independent technical solutions.

Claims

1. An anti-aging capsule composed of PQQ and mitochondrial nutrients, characterized in that: By weight, it includes the following ingredients: pyrrolidone disodium salt (PQQ) 1–20 mg, coenzyme Q10 20–100 mg, L-carnitine tartrate 50–200 mg, α-lipoic acid 10–100 mg, nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR) 50–300 mg, selenoprotein or organic selenium yeast 10–50 μg, capsule carrier including gelatin or plant-derived capsule shell 100 mg, microcrystalline cellulose 180 mg, magnesium stearate 5 mg, and silicon dioxide 5 mg.

2. The anti-aging capsule composed of PQQ and mitochondrial nutrients according to claim 1, characterized in that... The components are combined in the following ratio: PQQ∶Coenzyme Q10∶L-Carnitine∶α-Lipoic acid∶NMN = 1∶5∶10∶2∶10.

3. The anti-aging capsule composed of PQQ and mitochondrial nutrients according to claim 1, characterized in that... The PQQ is PQQ disodium salt with a purity of ≥98% and is derived from a bio-fermentation extract. The coenzyme Q10 is a micron-sized crystalline powder with a particle size controlled within 10-50 μm.

4. The anti-aging capsule formulated with PQQ and mitochondrial nutrients according to claim 1, characterized in that... The L-carnitine tartrate has a purity of ≥98%, and the α-lipoic acid is optically pure α-R-lipoic acid.

5. The anti-aging capsule formulated with PQQ and mitochondrial nutrients according to claim 1, characterized in that... The nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR) has a purity of ≥99% and is stored stably as a freeze-dried powder.

6. The anti-aging capsule formulated with PQQ and mitochondrial nutrients according to claim 1, characterized in that... The selenoprotein or selenium-enriched yeast powder contains selenium in a range of 30–200 μg / 100g.

7. The anti-aging capsule containing PQQ and mitochondrial nutrients according to claim 1, characterized in that... The anti-aging capsules are further fortified with one or more of the following synergistic antioxidant ingredients: vitamin E (α-tocopherol) 10-30 mg, vitamin C (ascorbic acid) 50-100 mg, zinc (such as zinc gluconate) 5-15 mg, and black pepper extract (piperine) 1-5 mg.

8. The anti-aging capsule composed of PQQ and mitochondrial nutrients according to claim 1, characterized in that... The capsule contains no artificial preservatives, artificial colors, sugar, or dairy products.

9. An anti-aging capsule composed of PQQ and mitochondrial nutrients according to claim 1, characterized in that... Each anti-aging capsule contains the following ingredients: 5 mg of PQQ disodium salt, 25 mg of coenzyme Q10, 50 mg of L-carnitine tartrate, 10 mg of α-lipoic acid, 50 mg of NMN, 20 μg of selenium-enriched yeast, combined with 200 mg of microcrystalline cellulose, 1 mg of magnesium stearate, and 1 mg of silicon dioxide, all encapsulated in a gelatin hollow capsule shell. Take 1-2 capsules daily for 8 weeks. This combination can significantly increase serum SOD activity and reduce MDA levels.

10. An anti-aging capsule composed of PQQ and mitochondrial nutrients according to claim 1, characterized in that... The anti-aging capsules contain 20 mg of vitamin E and 3 mg of black pepper extract, which can enhance antioxidant capacity and improve absorption efficiency.