Filtering device for biological medicine preparation

Abstract

The invention discloses a biological medicine preparation filtering device which comprises a first filtering module and a second filtering module, a solution is circularly filtered N times between the first filtering module and the second filtering module, N is an integer larger than or equal to 2, adjustable filtering membranes are arranged in the first filtering module and the second filtering module, and the solution is guided out from an output end after N times of filtering is completed. The adjusting mechanism can change the pore size of the adjustable filter membrane, and when N times of filtration are carried out, only the pore size of the adjustable filter membrane in the first filter module and the second filter module needs to be changed in sequence, and the solution is kept to form a circulation effect between the first filter module and the second filter module, so that compared with the traditional multi-stage filtration, a plurality of devices do not need to be connected in series to realize the filtration; moreover, the filtering level can be adaptively adjusted, and the utilization rate of the filtering device is improved.

Description

Technical Field

[0001] This invention relates to the field of production technology, and specifically to a filtration device for biopharmaceutical preparation. Background Technology

[0002] The initial preparation involves adding the photosensitizer to the resin and solvent for a full reaction. At this stage, the preliminary product still contains insoluble impurities from the solution and particulate matter introduced during the production process. It cannot be directly applied to the photolithography operation and needs to be filtered and purified.

[0003] For initial products, multi-stage filtration is required, which involves setting up multiple filtration devices to perform sequential filtration from coarse to fine, thereby obtaining the purity required for actual use.

[0004] The above-mentioned filtration device still has the following shortcomings in actual use: Firstly, multi-stage filtration requires multiple devices connected in series: the filtration devices need to be connected in multiple stages, and the combination of multiple sets of equipment results in a large space occupation, complex pipeline connections, high production costs, and low utilization rate of each stage of filtration device. Secondly, it lacks adaptability to the adjustment of filtration levels: the purity of products required in actual production is often uncertain. When a new filtration level is required, the original equipment is difficult to adjust to suit it. It can only be modified and connected to the corresponding filtration device, which is very troublesome to operate. Summary of the Invention

[0005] In order to overcome the above-mentioned technical problems, the purpose of this invention is to provide a biomedical preparation filtration device that can achieve multiple filtrations by using the cyclic action of two sets of filtration devices and the number of filtrations can be adjusted as needed.

[0006] The objective of this invention can be achieved through the following technical solutions: A biomedical preparation filtration device includes an input end for receiving a solution; The solution is circulated and filtered N times between the first filter module and the second filter module, where N is an integer greater than or equal to 2. Both the first filter module and the second filter module are equipped with adjustable filter membranes. Between 1 and N filtration cycles, odd-numbered filtration cycles are performed in the first filtration module, and even-numbered filtration cycles are performed in the second filtration module. When performing N-1 filtration cycles, the adjustable filter membrane pore size is larger than when performing N filtration cycles. At the output end, after N filtrations, the solution is discharged from the output end. Adjust the mechanism to change the pore size of the adjustable filter membrane.

[0007] As a further aspect of the present invention: the first filter module includes: The outer shell and the inner shell, with a cylindrical cavity provided between the outer shell and the inner shell; The input tube is connected to the cylindrical cavity, and the output tube is connected to the inner cavity of the inner shell. The solution enters the cylindrical cavity through the inlet pipe, is filtered through the adjustable filter membrane, enters the inner shell, and is output from the outlet pipe.

[0008] As a further aspect of the present invention: the input tube and the output tube are located on the same side of the first filter module, and the input tube and the cylindrical cavity have at least two connection points, with the connection points equally dividing the end of the cylindrical cavity.

[0009] As a further aspect of the present invention: an anti-backflow component is provided between the input pipe and the cylindrical cavity, the anti-backflow component comprising: The inner liner has a V-shaped groove recessed towards the inner shell side; Closing block one and closing block two, closing block one is elastic and can deflect around the V-shaped groove, and closing block two is provided with a protrusion protruding into the inner shell; When the solution does not enter through the inlet pipe, the first closing block matches the protrusion to form a sealing surface for the cylindrical cavity. After the solution enters through the inlet pipe, a gap is formed between the first closing block and the second closing block, which communicates with the cylindrical cavity.

[0010] As a further aspect of the present invention: the inlet of the first filter module is connected to the input end, the outlet of the first filter module is connected to the inlet of the second filter module, the outlet of the second filter module is connected to the inlet of the first filter module, and solenoid valves are provided between the inlet of the first filter module and the input end, between the outlet of the second filter module and the inlet of the first filter module, and at the output end, so that the solution is circulated and filtered under the action of the solenoid valves.

[0011] As a further aspect of the present invention: a transfer chamber is connected between the liquid outlet of the first filter module and the liquid inlet of the second filter module, and an electromagnetic valve for controlling the flow of solution is installed in the transfer chamber, and the transfer chamber is connected to the output end.

[0012] As a further aspect of the present invention: the adjusting mechanism includes: The elastic netting is attached inside the outer casing. A rigid adjustment component is installed around the elastic net to change the ease with which the rigid adjustable elastic net can expand. The adjustable filter membrane is hung on the inner wall of the elastic mesh. The pressure generated by the liquid passing through the adjustable filter membrane causes the adjustable filter membrane and the elastic mesh to expand together. The expansion of the elastic mesh is controlled by the rigid adjustment component. After the adjustable filter membrane expands, its pore size becomes larger. The rigid adjustment component includes a linear pusher, a connector, a flexible sleeve, and several springs. The flexible sleeve is sleeved around the spring. The spring is connected between the end of the outer shell and the connector. The connector moves back and forth under the action of the linear pusher. After the connector moves towards the linear pusher, the spring is tightened, the spring rigidity is increased, the elastic mesh is difficult to expand, and the adjustable filter membrane pore size is suppressed, so that the adjustable filter membrane pore size is maintained in a small range.

[0013] As a further aspect of the present invention: both the first filter module and the second filter module are equipped with rinsing components; The flushing component includes an inlet end and an outlet pipe. The inlet end is connected to the inner shell, and the outlet pipe is connected to the cylindrical cavity. When the pore size of the adjustable filter membrane needs to be changed by adjusting the mechanism during multi-stage filtration, the filtered solution is stored in the transfer chamber, the flushing component opens and closes the inlet and outlet of the first and second filter modules, and the solution in the first and second filter modules is flushed out.

[0014] As a further aspect of the present invention: the adjustable filter membrane is a UPE filter membrane, and the structure of the adjustable filter membrane becomes loose after expansion, thereby increasing the pore size of the adjustable filter membrane.

[0015] As a further aspect of the present invention: the adjustable filter membrane is made by rolling a PEEK membrane with numerous through holes, and the pore size of the through holes increases after the adjustable filter membrane expands.

[0016] The beneficial effects of this invention are: When performing N filtrations, it is only necessary to change the pore size of the adjustable filter membrane in the first and second filter modules in sequence, and maintain the solution in circulation between the first and second filter modules. Compared with traditional multi-stage filtration, it does not require multiple devices to be connected in series, and the filtration levels can be adjusted adaptively, which improves the utilization rate of the filtration device. In this invention, a horizontal orientation is adopted, which allows the solution to fill the cylindrical cavity. The flow rate of the solution on the adjustable filter membrane in each part is more uniform, and the utilization of the adjustable filter membrane is more complete. The solution is only allowed to be transported unidirectionally from the inlet pipe to the cylindrical cavity side to prevent the unfiltered solution from flowing back during the circulation filtration process. At this time, the pore size of the adjustable filter membrane has been adjusted, and the backflowed part of the solution is directly subjected to skip-stage filtration, which disrupts the normal multi-stage filtration process. The transfer chamber serves to redistribute and store the filtered solution. It can not only control the solution flow rate within a reasonable range, but also provide temporary storage space for the filtered solution when the adjustable filter membrane is adjusted in pore size. This is achieved by starting and stopping the solenoid valve installed in the transfer chamber. When the pore size of the adjustable filter membrane needs to be changed by adjusting the mechanism during multi-stage filtration, the filtered solution is stored in the transfer chamber. The flushing component opens and closes the inlet and outlet of the first and second filter modules, and the solution in the first and second filter modules is flushed out to prevent the filtration from the previous stages from adhering to the adjustable filter membrane and interfering with the subsequent stages of filtration. Attached Figure Description

[0017] The present invention will now be further described with reference to the accompanying drawings.

[0018] Figure 1 This is a schematic diagram of the solution circulation filtration structure implemented in this invention; Figure 2 This is a schematic diagram showing the flow of the solution during circulation filtration in this invention; Figure 3 This is a schematic diagram of the interaction structure between the first filter module and the second filter module of the present invention; Figure 4 This is an exploded structural diagram of the first filter module and adjustment mechanism of the present invention; Figure 5 This is a schematic diagram of the exploded structure of the adjustment mechanism of the present invention; Figure 6 This is a schematic diagram of the anti-backflow component during solution filtration of the present invention. Figure 7 This is a schematic diagram of the installation structure of the water inlet and outlet pipe relative to the first filter module and the second filter module of the present invention.

[0019] In the diagram: 1. Input end; 2. First filter module; 200. Outer shell; 201. Inner shell; 202. Cylindrical cavity; 203. Input pipe; 204. Output pipe; 3. Second filter module; 4. Output end; 5. Solenoid valve; 6. Transfer chamber; 700. Water inlet; 701. Discharge pipe; 8. Adjustment mechanism; 801. Linear pusher; 802. Connector; 803. Elastic mesh; 804. Adjustable filter membrane; 805. Spring; 806. Flexible sleeve; 9. Anti-backflow component; 901. Liner; 902. Closing block one; 903. Closing block two. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention. Example 1

[0021] like Figures 1 to 7As shown, a biopharmaceutical preparation filtration device includes an input end 1 for inputting a solution. The solution is circulated and filtered N times between a first filtration module 2 and a second filtration module 3, where N is an integer greater than or equal to 2. Both the first filtration module 2 and the second filtration module 3 are equipped with adjustable filter membranes 804. During the filtration process from 1 to N times, odd-numbered filtrations are performed in the first filtration module 2, and even-numbered filtrations are performed in the second filtration module 3. The pore size of the adjustable filter membrane 804 is larger during the N-1 filtrations than during the N filtrations. After N filtrations are completed, the solution is discharged from the output end 4. The pore size of the adjustable filter membrane 804 is changed by an adjustment mechanism 8. In this embodiment, the solution input end can be the crude solution obtained from the previous production equipment, such as a reaction vessel. In the reaction vessel, the photosensitizer monomer, film-forming resin, solvent, etc. are uniformly mixed and reacted. During the mixing reaction, the photosensitizer dissolves in the solvent, but some photosensitizer is not completely dissolved and forms a small number of particles suspended in the colloid. Therefore, it is necessary to filter it through the biomedical preparation filtration device proposed in this invention. The solution input end can input the solution to be filtered into the first filtration module 2. To fully demonstrate the cooperative function of the first filter module 2 and the second filter module 3 during multi-stage filtration, an example of four-stage filtration is provided below. The entire filtration process is as follows: refer to Figure 2 As shown, the solution to be filtered enters the first filter module 2 from the solution input end in the direction of the arrow in the figure. At this time, the pore size of the adjustable filter membrane 804 in the first filter module 2 is changed in advance by the adjustment mechanism 8 (denoted as M1), and the pore size of the adjustable filter membrane 804 in the second filter module 3 is changed (denoted as M2). Note: The first filter module 2 and the second filter module 3 have completely identical structures. In this application, only the first filter module 2 is described in detail for the sake of brevity. However, it should be clear that the second filter module 3 has the same function as the first filter module 2. Continuing from the above, the solution to be filtered enters the first filter module 2, passes through the adjustable filter membrane 804 with a pore size of M1 for the first filtration, and then exits the first filter module 2 and enters the second filter module 3, passing through the adjustable filter membrane 804 with a pore size of M2 for the second filtration. After the second filtration is completed, the solution in the first filter module 2 is emptied, and the adjustment mechanism 8 is driven again to change the pore size (denoted as M3) of the adjustable filter membrane 804 in the first filter module 2. The solution after the second filtration flows... Figure 2The direction indicated by the middle arrow is from the output port of the second filter module 3 to the input port of the first filter module 2, and enters the first filter module 2 with the pore size of the adjustable filter membrane 804 reset. After passing through the adjustable filter membrane 804 with a pore size of M3, the solution is filtered for the third time. After the third filtration is completed, the solution in the second filter module 3 is emptied. The adjustment mechanism 8 is driven again to change the pore size of the adjustable filter membrane 804 in the second filter module 3 (denoted as M4). The fourth filtration is carried out in the second filter module 3 in the same way as described above, completing the entire filtration process when N=4. In the above filtration process, the pore sizes of the adjustable filter membrane 804 are as follows: M1 > M2 > M3 > M4 Following the same principle of filtration, when performing N filtrations, simply change the pore size of the adjustable filter membrane 804 in the first filter module 2 and the second filter module 3 sequentially in the same manner, while maintaining the solution between the first filter module 2 and the second filter module 3 as described above. Figure 2 The cycle shown is sufficient. When the Nth filtration is performed, the pore size relationship of the adjustable filter membrane 804 is as follows: M1>M2>M3>M4>……>M N-1 >M N Example 2

[0022] like Figures 1 to 4 As shown, based on Embodiment 1, this application defines the specific filtration methods in the first filter module 2 and the second filter module 3 based on the characteristics of the actual filtration effect: The first filter module 2 includes an outer shell 200, an inner shell 201, an input pipe 203, and an output pipe 204. A cylindrical cavity 202 is provided between the outer shell 200 and the inner shell 201. The input pipe 203 is connected to the cylindrical cavity 202, and the output pipe 204 is connected to the inner cavity of the inner shell 201. The solution enters the cylindrical cavity 202 from the input pipe 203, is filtered by the adjustable filter membrane 804, enters the inner shell 201, and is output from the output pipe 204. refer to Figure 3 Firstly, conventional filtration methods employ vertically oriented filtration devices, while in this application, both the first filter module 2 and the second filter module 3 are configured horizontally (as mentioned in Embodiment 1, the specific configurations of the first filter module 2 and the second filter module 3 are identical). (See reference...) Figure 4 After the solution enters the cylindrical cavity 202, due to its high viscosity, a horizontal orientation before filtration ensures sufficient filling of the cavity. In a traditional vertical structure, the lower half of the filter membrane is expected to be significantly more filled than the upper half, potentially leading to incomplete utilization of the upper filter membrane. However, the horizontal orientation used in this invention ensures that the solution... Figure 6 The state shown in the diagram fills the cylindrical cavity 202, and the flow of solution through the adjustable filter membrane 804 in each part is more uniform, making more complete use of the adjustable filter membrane 804. Furthermore, a certain diversion function is set in the solution input stage. The input pipe 203 and the output pipe 204 are located on the same side of the first filter module 2, and the input pipe 203 and the cylindrical cavity 202 have at least two connection points. The connection points are equally divided at the end of the cylindrical cavity 202. The overall input part is a circular surface. If the diversion function is lacking, the input point will be singular, which will have a large impact on the adjustable filter membrane 804 on one side. The form of setting multiple input points that evenly divide the circular surface can better balance the impact and further improve the uniformity of the filtration effect. Example 3

[0023] refer to Figure 6 As shown, based on the above embodiments, the present invention further specifies the flow of the solution during the filtration process: An anti-backflow component 9 is provided between the input pipe 203 and the cylindrical cavity 202. The anti-backflow component 9 includes an inner liner 901, a first closing block 902 and a second closing block 903. The inner liner 901 is provided with a V-shaped groove recessed towards the inner shell 201. The first closing block 902 is elastic and can deflect around the V-shaped groove. The second closing block 903 is provided with a protrusion protruding towards the inner shell 201. When the solution does not enter through the inlet pipe 203, the first closing block 902 matches the protrusion to form a sealing surface for the cylindrical cavity 202. After the solution enters through the inlet pipe 203, a gap is formed between the first closing block 902 and the second closing block 903 that communicates with the cylindrical cavity 202. Under the above settings, the solution is only allowed to be transported unidirectionally from the input pipe 203 to the cylindrical cavity 202 side, preventing the unfiltered solution from flowing back during the circulation filtration process. At this time, the pore size of the adjustable filter membrane 804 has been adjusted, and the backflowed part of the solution is directly subjected to skip-stage filtration, which disrupts the normal multi-stage filtration process. Example 4

[0024] like Figures 1 to 7 As shown, based on the above embodiments, in this invention, the inlet of the first filter module 2 is connected to the input end 1, the outlet of the first filter module 2 is connected to the inlet of the second filter module 3, the outlet of the second filter module 3 is connected to the inlet of the first filter module 2, and solenoid valves 5 are provided between the inlet of the first filter module 2 and the input end 1, between the outlet of the second filter module 3 and the inlet of the first filter module 2, and at the output end 4. Under the action of the solenoid valves 5, the solution is circulated and filtered. The solenoid valves 5 control the flow of the solution at key points, providing assistance for the circulation and filtration of the solution. In practical use, the flow meters and solenoid valves 5 installed at the outlets of the first filter module 2 and the second filter module 3 also need to be used in conjunction. Taking a three-stage circulating filtration process as an example, refer to... Figure 2 As shown, first open the solenoid valve 5 at input end 1 to allow the solution to enter the first filter module 2 for the first stage of filtration. The flow meter at the outlet of the first filter module 2 detects that the solution is passing through at a constant rate, indicating that the first stage of filtration is nearly complete. The solution then fills the second filter module 3 for the second stage of filtration. After the adjustable filter membrane 804 in the first filter module 2 is adjusted, close the solenoid valve 5 at input end 1 and open the solenoid valve 5 between the outlet of the second filter module 3 and the inlet of the first filter module 2. The solution that has completed the second stage of filtration is then drawn back into the first filter module 2 for the third stage of filtration. Example 5

[0025] like Figures 1 to 3 As shown, based on the above embodiments, the present invention connects a transfer chamber 6 between the liquid outlet of the first filter module 2 and the liquid inlet of the second filter module 3. The transfer chamber 6 is equipped with a solenoid valve 5 for controlling the flow of solution. The transfer chamber 6 is connected to the output end 4. The transfer chamber 6 serves to redistribute and store the filtered solution. It can not only control the solution flow rate within a reasonable range, but also provide temporary storage space for the filtered solution when the adjustable filter membrane 804 is adjusted in pore size. This is achieved by starting and stopping the solenoid valve 5 installed in the transfer chamber 6. Example 6

[0026] like Figure 5 As shown, based on Embodiment 1, the specific mechanism by which the adjusting mechanism 8 changes the pore size of the adjustable filter membrane 804 is as follows: Adjustment mechanism 8 includes: Elastic netting 803 is hung inside the outer casing 200; A rigid adjustment component is arranged around the elastic net 803 to change the ease with which the rigidity of the adjustable elastic net 803 can be expanded. The adjustable filter membrane 804 is hung on the inner wall of the elastic net 803. The pressure generated by the liquid passing through the adjustable filter membrane 804 causes the adjustable filter membrane 804 and the elastic net 803 to expand together. The expansion amount of the elastic net 803 is controlled by the rigid adjustment component. After the adjustable filter membrane 804 expands, its pore size becomes larger. The rigid adjustment component includes a linear pusher 801, a connector 802, a flexible sleeve 806, and several springs 805. The flexible sleeve 806 is sleeved around the spring 805. The spring 805 is connected between the end of the outer shell 200 and the connector 802. The connector 802 moves back and forth under the action of the linear pusher 801. After the connector 802 moves towards the linear pusher 801, the spring 805 is tightened, the rigidity of the spring 805 is increased, the elastic mesh 803 is difficult to expand, and the effect of inhibiting the increase of the pore size of the adjustable filter membrane 804 is suppressed, so that the pore size of the adjustable filter membrane 804 is maintained in a small range. In summary, the linear pusher 801 can be made of cylinder, electric push rod, or other means. When the linear pusher 801 generates an outward pulling action, the pore size of the adjustable filter membrane 804 is maintained in a smaller range, corresponding to the filtration effect in the later stage. Conversely, when the linear pusher 801 generates an inward pushing action, the suppression of the expansion of the pore size of the adjustable filter membrane 804 is weakened, corresponding to the filtration effect in the earlier stage.

[0027] Regarding the specific form of the adjustable filter membrane 804, this embodiment provides the following two forms for selection in actual use: The adjustable filter membrane 804 is a UPE filter membrane. After the adjustable filter membrane 804 expands, its structure becomes loose, thereby increasing the pore size of the adjustable filter membrane 804. UPE filter membrane is a high-molecular chemical material with a porous sponge-like structure. When the hydraulic pressure inside the adjustable filter membrane 804 expands it, the sponge-like structure inside becomes loose, thereby increasing the pore size. By controlling the rigidity of the spring 805, the degree of deformation of the elastic net 803 can be controlled, thereby controlling the expansion of the UPE filter membrane and thus the pore size of the UPE filter membrane. The adjustable filter membrane 804 is made by rolling a PEEK membrane with many through holes. When the adjustable filter membrane 804 expands, the pore size of the through holes becomes larger. PEEK membranes are dense membranes. When rolled with numerous through-holes, these through-holes with a certain pore size serve as filter pores. When a PEEK membrane is filled with liquid and expands, its pores will also enlarge, thus enabling controllable filter pore size. Example 7

[0028] Based on the above embodiments, refer to Figures 1 to 7 As shown, both the first filter module 2 and the second filter module 3 are equipped with flushing components; The flushing component includes a water inlet 700 and a discharge pipe 701. The water inlet 700 is connected to the inner shell 201, and the discharge pipe 701 is connected to the cylindrical cavity 202. When the pore size of the adjustable filter membrane 804 needs to be changed by adjusting mechanism 8 during multi-stage filtration, the filtered solution is stored in transfer chamber 6. The flushing component opens and closes the inlet and outlet of the first filter module 2 and the second filter module 3, and the solution in the first filter module 2 and the second filter module 3 is flushed out to prevent the filtration from the previous stage from adhering to the adjustable filter membrane 804 and interfering with the subsequent stage filtration.

[0029] In the description of this invention, it should be understood that the terms "upper," "lower," "left," and "right," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or a specific orientational structure and operation. Therefore, they should not be construed as limitations on the invention. Furthermore, "first" and "second" are only for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "multiple" means two or more.

[0030] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0031] The foregoing has provided a detailed description of one embodiment of the present invention, but this description is merely a preferred embodiment and should not be construed as limiting the scope of the invention. All equivalent variations and modifications made within the scope of the claims of this invention should still fall within the patent coverage of this invention.

Claims

1. A biopharmaceutical preparation filtration device, characterized in that, include: Input terminal (1), input solution; The first filter module (2) and the second filter module (3) are used to filter the solution N times between the first filter module (2) and the second filter module (3), where N is an integer greater than or equal to 2. Both the first filter module (2) and the second filter module (3) are equipped with adjustable filter membranes (804). Between 1 and N filtration cycles, odd-numbered filtration cycles are performed in the first filtration module (2), and even-numbered filtration cycles are performed in the second filtration module (3). When performing N-1 filtration cycles, the pore size of the adjustable filter membrane (804) is larger than that when performing N filtration cycles. After N filtrations, the solution is discharged from the output end (4); Adjustment mechanism (8) changes the pore size of adjustable filter membrane (804).

2. The biopharmaceutical preparation filtration device according to claim 1, characterized in that, The first filter module (2) includes: The outer shell (200) and the inner shell (201) are provided with a cylindrical cavity (202) between the outer shell (200) and the inner shell (201). The input tube (203) and the output tube (204) are connected. The input tube (203) is connected to the cylindrical cavity (202), and the output tube (204) is connected to the inner cavity of the inner shell (201). The solution enters the cylindrical cavity (202) through the input pipe (203), is filtered by the adjustable filter membrane (804), enters the inner shell (201), and is output from the output pipe (204).

3. The biopharmaceutical preparation filtration device according to claim 2, characterized in that, The input tube (203) and the output tube (204) are located on the same side of the first filter module (2), and the input tube (203) and the cylindrical cavity (202) have at least two connection points, which are equally divided at the end of the cylindrical cavity (202).

4. The biopharmaceutical preparation filtration device according to claim 3, characterized in that, An anti-backflow component (9) is provided between the input pipe (203) and the cylindrical cavity (202). The anti-backflow component (9) includes: The inner liner (901) has a V-shaped groove recessed towards the inner shell (201); Closing block one (902) and closing block two (903), closing block one (902) is elastic and can deflect around the V-groove, and closing block two (903) is provided with a protrusion protruding into the inner shell (201); When the solution does not enter through the inlet pipe (203), the first closing block (902) matches the protrusion to form a sealing surface for the cylindrical cavity (202). After the solution enters through the inlet pipe (203), a gap is formed between the first closing block (902) and the second closing block (903) that communicates with the cylindrical cavity (202).

5. The biopharmaceutical preparation filtration device according to claim 1, characterized in that, The inlet of the first filter module (2) is connected to the input end (1), the outlet of the first filter module (2) is connected to the inlet of the second filter module (3), the outlet of the second filter module (3) is connected to the inlet of the first filter module (2), and solenoid valves (5) are provided between the inlet of the first filter module (2) and the input end (1), between the outlet of the second filter module (3) and the inlet of the first filter module (2), and at the output end (4). The solution is circulated and filtered under the action of the solenoid valves (5).

6. The biopharmaceutical preparation filtration device according to claim 1, characterized in that, A transfer chamber (6) is connected between the outlet of the first filter module (2) and the inlet of the second filter module (3). The transfer chamber (6) is equipped with a solenoid valve (5) to control the flow of solution. The transfer chamber (6) is connected to the output end (4).

7. A biopharmaceutical preparation filtration device according to claim 2, characterized in that, The adjustment mechanism (8) includes: The elastic net (803) is hung inside the outer casing (200); A rigid adjustment component is arranged around the elastic net (803) to change the ease of expansion of the rigid adjustable elastic net (803). An adjustable filter membrane (804) is hung on the inner wall of an elastic net (803). The pressure generated by the liquid passing through the adjustable filter membrane (804) causes the adjustable filter membrane (804) and the elastic net (803) to expand together. The expansion amount of the elastic net (803) is controlled by a rigid adjustment element. After the adjustable filter membrane (804) expands, its pore size becomes larger. The rigid adjustment component includes a linear pusher (801), a connector (802), a flexible sleeve (806), and several springs (805). The flexible sleeve (806) is sleeved around the spring (805). The spring (805) is connected between the end of the outer shell (200) and the connector (802). The connector (802) moves back and forth under the action of the linear pusher (801). After the connector (802) moves towards the linear pusher (801), the spring (805) is tightened, the rigidity of the spring (805) is increased, the elastic mesh (803) is difficult to expand, and the effect of suppressing the increase of the pore size of the adjustable filter membrane (804) is suppressed, so that the pore size of the adjustable filter membrane (804) is maintained in a small range.

8. A biopharmaceutical preparation filtration device according to claim 6, characterized in that, Both the first filter module (2) and the second filter module (3) are equipped with rinsing components; The flushing component includes an inlet end (700) and a discharge pipe (701). The inlet end (700) is connected to the inner shell (201), and the discharge pipe (701) is connected to the cylindrical cavity (202). When the pore size of the adjustable filter membrane (804) needs to be changed by adjusting mechanism (8) during multi-stage filtration, the filtered solution is stored in transfer chamber (6), the flushing component opens and closes the inlet and outlet of the first filter module (2) and the second filter module (3), and the solution in the first filter module (2) and the second filter module (3) is flushed out.

9. A biopharmaceutical preparation filtration device according to claim 1, characterized in that, The adjustable filter membrane (804) is a UPE filter membrane. After the adjustable filter membrane (804) expands, its structure becomes loose, thereby increasing the pore size of the adjustable filter membrane (804).

10. A biopharmaceutical preparation filtration device according to claim 1, characterized in that, The adjustable filter membrane (804) is made by rolling a PEEK membrane with many through holes. After the adjustable filter membrane (804) expands, the pore size of the through holes becomes larger.

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