Microfluidic analysis equipment

Abstract

The invention belongs to the technical field of microfluidic detection, and relates to microfluidic analysis equipment which comprises a lower shell, an outer shell, an inner lower shell, an inner upper shell, a kit mounting seat, a driving device, a magnet moving structure, a pressing structure and other core components. A kit mounting seat in the inner lower shell can be driven by a driving device to slide, a magnet moving structure drives a magnet to move along a magnet slideway of the kit to promote a micro-flow reaction, and a pressing structure presses a pressing part of the kit to assist the reaction; meanwhile, structures such as slide rail and slide block matching, motor lead screw transmission, two-dimensional code scanning, light path adjustment and temperature control are integrated, so that accurate positioning, intelligent adaptation and stable reaction environment of the kit are realized, and the detection accuracy is improved. The problems that an existing device is single in driving mode and insufficient in detection precision are solved, and the device is compact in structure, high in universality and capable of being widely applied to the fields of medical diagnosis, environment monitoring and the like.

Description

Technical Field

[0001] This invention belongs to the field of microfluidic detection technology and relates to a microfluidic analysis device. Background Technology

[0002] Microfluidic technology, with its advantages of low reagent consumption, fast reaction speed, and high detection sensitivity, has been widely used in medical diagnostics, environmental monitoring, food safety, and other fields. However, existing microfluidic analysis devices still have key bottlenecks in their core performance: on the one hand, the fluid driving methods are limited, mostly relying on mechanical pressure or a single magnetic field, making it difficult to adapt to the microfluidic requirements of reagents with different viscosities, resulting in incomplete mixing and low efficiency; on the other hand, the accuracy of the detection system is insufficient, and the light adjustment lacks a flexible adaptation mechanism, both of which affect the accuracy and repeatability of the detection results, failing to meet the needs of high-precision detection scenarios. Summary of the Invention

[0003] The purpose of this invention is to solve the above-mentioned problems and provide a microfluidic analysis device.

[0004] To achieve the above objectives, the present invention provides a microfluidic analysis device, including a lower housing and an outer housing. The lower housing is provided with an inner lower housing and an inner upper housing connected to the inner lower housing. The inner lower housing is provided with an opening and closing door. A reagent kit mounting seat is slidably provided inside the inner lower housing for fixing the reagent kit. A driving device is also provided inside the inner lower housing to drive the reagent kit mounting seat to move. A magnet moving structure and a pressing structure are fixedly installed on the upper end face of the inner lower shell. The reagent kit is provided with a magnet slide and multiple pressing parts. The magnet moving structure includes a second driving device and a magnet connected to the second driving device. The second driving device drives the magnet to move along the magnet slide to promote microflow reaction. The pressing structure is used to press multiple pressing parts to realize microflow reaction.

[0005] Furthermore, the inner lower shell is provided with a slide rail, and the reagent kit mounting base is provided with a slider that slides in conjunction with the slide rail; The drive unit includes a drive motor and a motor screw connected to the drive motor. A movable plate is fitted on the motor screw, and the movable plate is fixedly connected to the reagent kit mounting base.

[0006] Furthermore, the reagent kit mounting base includes a base and a reagent kit positioning block located on the upper side of the base and fixedly connected to the base, and the slider is detachably and fixedly connected to the reagent kit positioning block; The reagent kit positioning block has a mounting slot, and the reagent kit is placed in the mounting slot. The mounting slot has a through hole that penetrates the reagent kit positioning block itself. The base has a cavity, and a QR code scanner is installed in the cavity. The QR code scanner is located directly below the through hole and is used to scan the QR code on the reagent kit.

[0007] Furthermore, the mounting slot is also provided with a fixing slot and a sliding slot. The sliding slot has a light-transmitting hole that passes through the reagent kit positioning block. A photomultiplier tube is provided on the lower side of the reagent kit positioning block, directly opposite the light-transmitting hole. The slide is fitted with a light adjustment plate, which has a dimming hole. A fixing plate is installed at the fixing slot, and the fixing plate has a light transmission hole located directly above the light transmission hole.

[0008] Furthermore, the light adjustment plate is connected to a connecting plate, and a guide rail is provided on the lower side of the reagent kit positioning block, with the connecting plate slidingly engaging with the guide rail; The lower side of the reagent kit positioning block is also equipped with a lead screw motor, an output lead screw, and a transmission block that cooperates with the output lead screw. The transmission block is fixedly connected to the connecting plate.

[0009] Furthermore, a temperature sensor is provided on one side of the reagent kit positioning block, and the reagent kit positioning block is also equipped with a heating band.

[0010] Furthermore, the second drive device includes a fixed frame fixed on the inner lower shell, a second drive motor and a second motor screw mounted on the fixed frame, a sliding block fitted on the second motor screw, a mounting plate fixed on the sliding block, a linear stepper motor mounted on the mounting plate, a magnet mounting seat connected to the linear stepper motor, a cavity with a spring installed in the cavity, a magnet fixedly connected to the other end of the spring, a limiting groove on the side wall of the cavity, and a limiting post on the magnet that cooperates with the limiting groove.

[0011] Furthermore, the pressing structure includes a second fixing frame fixed on the inner lower shell, and a plurality of second linear stepper motors mounted on the second fixing frame, with the second linear stepper motors connected to pressure blocks.

[0012] The beneficial effects of this invention are as follows: The microfluidic analysis device of the present invention integrates a dual fluid drive structure of magnet drive and pressure drive, which can work independently or collaboratively according to the reagent viscosity and reaction process requirements. It effectively solves the problem of the single drive mode in the prior art, realizes the full mixing and efficient reaction of reagents with different properties, and greatly improves the adaptability and reaction efficiency of microfluidic reactions.

[0013] The microfluidic analysis device of the present invention achieves precise adaptation of light intensity by driving a light adjustment plate with a lead screw motor in terms of optical path adjustment, and maintains the stability of the reaction environment by adopting a monitoring-compensation closed-loop logic in terms of temperature control. The two work together to solve the core pain point of insufficient detection accuracy in existing technologies and significantly improve the accuracy and repeatability of detection results.

[0014] The microfluidic analysis device of the present invention integrates a QR code scanning function, which can quickly identify reagent kit information and automatically adapt to the detection program; each component is modularly designed and some parts can be disassembled and connected, reducing the difficulty of disassembly and maintenance, and taking into account the intelligence, precision and practicality of the device.

[0015] The microfluidic analysis device of the present invention has a compact overall structure and highly integrated functional modules. It not only meets the high-precision detection needs of the laboratory, but also adapts to rapid on-site detection scenarios. It can be widely used in multiple fields such as medical diagnosis, environmental monitoring, and food safety, and has strong market application value and promotion prospects. Attached Figure Description

[0016] Figure 1 A schematic perspective view of a microfluidic analysis device according to an embodiment of the present invention; Figure 2 This schematic diagram shows a front view of a microfluidic analysis device according to one embodiment of the present invention; Figure 3 This diagram schematically illustrates a microfluidic analysis device according to an embodiment of the present invention with its door in an open state. Figure 4 A schematic diagram illustrating the internal structure of a microfluidic analysis device according to one embodiment of the present invention; Figure 5 This diagram schematically illustrates the internal structure of a microfluidic analysis device according to one embodiment of the present invention. Figure 6 This diagram illustrates the internal structure of a microfluidic analysis device according to an embodiment of the present invention. Figure 2 ; Figure 7 This schematic diagram shows a front view of the internal structure of a microfluidic analysis device according to an embodiment of the present invention. Figure 8 A schematic top view illustrating the internal structure of a microfluidic analysis device according to an embodiment of the present invention; Figure 9 This diagram schematically illustrates the fit between the reagent kit mounting base and the inner lower shell according to one embodiment of the present invention. Figure 10 The schematic diagram shows a front view of a reagent kit mounting base and an inner lower shell according to an embodiment of the present invention. Figure 11 A schematic diagram illustrating the engagement of a reagent kit mounting base and a driving device according to an embodiment of the present invention; Figure 12 A schematic front view illustrating the assembly of a reagent kit mounting base and a drive device according to an embodiment of the present invention; Figure 13A schematic perspective view of a reagent kit mounting base according to an embodiment of the present invention; Figure 14 Schematic representation of a three-dimensional reagent kit mounting base according to an embodiment of the present invention. Figure 2 ; Figure 15 This schematic diagram shows an exploded view of the structure of a reagent kit mounting base according to one embodiment of the present invention; Figure 16 Schematic illustration of a structural explosion of a reagent kit mounting base according to an embodiment of the present invention. Figure 2 ; Figure 17 A schematic perspective view of a reagent kit positioning block according to an embodiment of the present invention; Figure 18 This schematic diagram illustrates the structure of a reagent kit positioning block without a fixing plate according to one embodiment of the present invention. Figure 19 This schematic diagram illustrates the structure of a fixing plate according to one embodiment of the present invention. Figure 20 This diagram schematically illustrates the bottom of a reagent kit positioning block according to one embodiment of the present invention. Figure 21 A schematic diagram illustrating a magnet moving structure according to an embodiment of the present invention; Figure 22 This schematic diagram illustrates the structure of a magnet moving structure according to one embodiment of the present invention. Figure 2 ; Figure 23 This diagram schematically illustrates a magnet mounting base and magnet mounting according to one embodiment of the present invention. Figure 24 The diagram schematically illustrates the structure of a pressing structure according to one embodiment of the present invention.

[0017] The meanings of the numbers in the attached diagram are as follows: 1. Lower shell; 2. Outer shell; 3. Inner lower shell; 4. Inner upper shell; 5. Opening door; 6. Reagent kit mounting base; 7. Reagent kit; 8. Drive mechanism; 9. Magnet moving structure; 10. Pressing structure; 71. Magnet slide; 72. Pressing part; 91. Second drive mechanism; 92. Magnet; 31. Slide rail; 61. Slider; 81. Drive motor; 82. Motor lead screw; 83. Moving plate; 62. Base; 63. Reagent kit positioning block; 64. Mounting slot; 65. Through hole; 66. QR code scanner; 641. Fixing slot; 642. Slide groove; 67. Light transmission hole; 68. Photomultiplier tube; 69. Light adjustment Plate; 691, Dimming hole; 610, Fixing plate; 611, Light-transmitting hole; 612, Connecting plate; 613, Guide rail; 614, Lead screw motor; 615, Output lead screw; 616, Transmission block; 617, Temperature sensor; 618, Heating belt; 911, Fixing frame; 912, Second drive motor; 913, Second motor lead screw; 914, Sliding block; 915, Mounting plate; 916, Linear stepper motor; 917, Magnet mounting base; 918, Cavity; 919, Spring; 920, Limiting groove; 921, Limiting post; 101, Second fixing frame; 102, Second linear stepper motor; 103, Pressure block. Detailed Implementation

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly described below. Obviously, the drawings described below are merely some embodiments of the present invention, and those skilled in the art can obtain other drawings based on these drawings without creative effort.

[0019] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. The embodiments cannot be described in detail here, but the embodiments of the present invention are not limited to the following embodiments.

[0020] Combination Figures 1-24 As shown, the connection relationships, working principles, and collaborative logic of the various components of the microfluidic analysis device of the present invention are as follows: The main support structure of this device consists of a lower shell 1, an outer shell 2, an inner lower shell 3, and an inner upper shell 4. The inner lower shell 3 and the inner upper shell 4 are fixedly connected to form a closed internal working space. The opening and closing door 5 on the inner lower shell 3 can be opened and closed flexibly to provide a channel for taking out and putting in the reagent kit 7.

[0021] The reagent kit mounting base 6 is slidably mounted inside the inner lower shell 3. Its core function is to fix the reagent kit 7 and move it. The drive device 8 configured inside the inner lower shell 3 provides power for the movement of the reagent kit mounting base 6. Two sets of core functional components, a magnet moving structure 9 and a pressing structure 10, are fixedly mounted on the upper end face of the inner lower shell 3. They respectively correspond to and cooperate with the magnet slide 71 and multiple pressing parts 72 on the reagent kit 7.

[0022] The magnet moving structure 9 consists of a second driving device 91 and a magnet 92. The second driving device 91 is fixedly connected to the magnet 92 and can drive the magnet 92 to move linearly along the magnet slide 71 of the reagent kit 7. The magnetic force drives the magnetic particles or fluid in the reagent kit 7 to flow, thereby promoting the microflow reaction. The pressing structure 10 realizes the pushing and mixing of reagents by mechanically pressing multiple pressing parts 72 on the reagent kit 7, thereby assisting in the completion of the microflow reaction. The two driving methods can operate independently or work together to adapt to different reaction requirements.

[0023] According to one embodiment of the present invention, in order to achieve smooth and precise movement of the reagent kit mounting base 6, two parallel slide rails 31 are arranged opposite each other on the inner lower shell 3, and sliders 61 are installed on both sides of the reagent kit mounting base 6. The sliders 61 and the slide rails 31 form a sliding structure with clearance fit to ensure that the reagent kit mounting base 6 moves without jamming or deviation.

[0024] According to one embodiment of the present invention, the drive device 8 adopts a motor screw transmission scheme, including a drive motor 81, a motor screw 82, and a moving plate 83. The drive motor 81 is fixedly installed at the end of the inner lower shell 3. One end of the motor screw 82 is fixedly connected to the output shaft of the drive motor 81 through a coupling, and the other end is rotatably connected to the inner lower shell 3 through a bearing seat. One side of the moving plate 83 is provided with a threaded hole adapted to the motor screw 82, and the other side is fixedly connected to the bottom of the reagent kit mounting base 6 by bolts. When the drive motor 81 is started, the motor screw 82 rotates, driving the moving plate 83 to move along the axis of the motor screw 82 through thread transmission, thereby driving the reagent kit mounting base 6 to perform linear reciprocating motion along the slide rail 31.

[0025] In this embodiment, the reagent kit mounting base 6 adopts a split design, consisting of a base 62 and a reagent kit positioning block 63. The reagent kit positioning block 63 is fixed to the upper side of the base 62 by bolts. The slider 61 is detachably fixed to the reagent kit positioning block 63 (e.g., bolt connection), facilitating later maintenance and replacement. The upper surface of the reagent kit positioning block 63 has a mounting groove 64 adapted to the shape of the reagent kit 7. After the reagent kit 7 is placed in the mounting groove 64, initial positioning can be achieved. The bottom of the mounting groove 64 has a through hole 65 penetrating the reagent kit positioning block 63. A cavity is reserved inside the base 62, and a QR code scanner 66 is fixedly installed in the cavity, with the scanning lens of the QR code scanner 66 directly below the through hole 65. When the reagent kit 7 is in place, the QR code on its bottom is exactly above the through hole 65. The QR code scanner 66 can quickly scan the QR code through the through hole 65 to obtain information such as the type, batch number, reaction parameters, and expiration date of the reagent kit 7, providing data support for the device to automatically match the detection program.

[0026] According to one embodiment of the present invention, in order to ensure the accuracy of optical detection, the mounting groove 64 of the reagent kit positioning block 63 is further provided with a fixing groove 641 and a sliding groove 642. The fixing groove 641 is located at the edge of the mounting groove 64, and the sliding groove 642 extends along the length direction of the reagent kit positioning block 63.

[0027] A light-transmitting hole 67 is provided at the bottom of the slide 642, penetrating the reagent kit positioning block 63. A photomultiplier tube 68 is fixedly installed on the lower side of the reagent kit positioning block 63, directly opposite the light-transmitting hole 67, with the photosensitive surface of the photomultiplier tube 68 aligned with the light-transmitting hole 67. A light adjustment plate 69 is slidably installed inside the slide 642, and a circular dimming hole 691 is provided on the light adjustment plate 69. A fixing plate 610 is fixedly installed in the fixing groove 641 by bolts, with the light-transmitting hole 611 on the fixing plate 610 coaxially aligned with the light-transmitting hole 67, forming a complete optical path channel.

[0028] According to one embodiment of the present invention, in order to achieve precise adjustment of light intensity, one end of the light adjustment plate 69 is fixedly connected to the connecting plate 612 by bolts. The lower side of the reagent kit positioning block 63 is fixedly mounted with a guide rail 613. The lower surface of the connecting plate 612 is provided with a slider structure adapted to the guide rail 613, and the two form a sliding fit. The lower side of the reagent kit positioning block 63 is also equipped with a lead screw motor 614, an output lead screw 615, and a transmission block 616. The lead screw motor 614 is fixed to the reagent kit positioning block 63 by a motor seat. One end of the output lead screw 615 is fixedly connected to the output shaft of the lead screw motor 614, and the other end is rotatably connected to the reagent kit positioning block 63 through a bearing seat. One side of the transmission block 616 is provided with a threaded hole adapted to the output lead screw 615, and the other side is fixedly connected to the connecting plate 612. When the lead screw motor 614 starts, the output lead screw 615 rotates, driving the transmission block 616 to move along the axis of the output lead screw 615. This, in turn, drives the light adjustment plate 69 to slide along the slide groove 642 through the connecting plate 612, changing the overlapping area of ​​the dimming hole 691 and the light transmission hole 67, thereby realizing graded adjustment of light intensity and avoiding the problem of strong light saturation or weak light not being detectable.

[0029] According to one embodiment of the present invention, to ensure that the biochemical reaction proceeds in a stable temperature environment, a temperature sensor 617 is fixedly installed on one side of the reagent kit positioning block 63 by a snap-fit. The detection end of the temperature sensor 617 is in close contact with the surface of the reagent kit positioning block 63, allowing real-time monitoring of the temperature of the reagent kit positioning block 63, thereby indirectly reflecting the reaction temperature of the reagent kit 7. A heating band 618 is fixed to the lower side of the reagent kit positioning block 63. The heating band 618 is made of silicone heating pad material and is in close contact with the surface of the reagent kit positioning block 63 to ensure heat transfer efficiency. Both the temperature sensor 617 and the heating band 618 are electrically connected to the control system of the equipment, forming a closed-loop temperature control. When the temperature sensor 617 detects that the temperature is lower than the set value, the control system starts the heating band 618 to heat; when the temperature reaches the set value, the heating band 618 stops heating or enters a heat preservation state, ensuring that the temperature fluctuation range of the reaction environment is controlled within ±0.5℃.

[0030] According to one embodiment of the present invention, the fixing frame 911 of the second driving device 91 is fixed to the upper end face of the inner lower shell 3 by bolts. The second driving motor 912 and the second motor lead screw 913 are mounted on the fixing frame 911. The second driving motor 912 and the second motor lead screw 913 are connected by a coupling. A sliding block 914 is fitted on the second motor lead screw 913. The sliding block 914 is slidably engaged with the guide rail on the fixing frame 911. A mounting plate 915 is fixedly mounted on the upper surface of the sliding block 914. A linear stepper motor 916 is vertically mounted on the mounting plate 915. The output shaft of the linear stepper motor 916 is fixedly connected to the magnet mounting base 917. The magnet mounting base 917 has a cylindrical cavity 918 inside, and a spring 919 is installed inside the cavity 918. One end of the spring 919 is fixedly connected to the bottom of the cavity 918, and the other end is fixedly connected to the magnet 92. An axial limiting groove 920 is opened on the side wall of the cavity 918, and a corresponding limiting post 921 is provided on the side wall of the magnet 92. The limiting post 921 is inserted into the limiting groove 920 to form a sliding fit, thereby restricting the rotational freedom of the magnet 92.

[0031] When the horizontal position of magnet 92 needs to be adjusted, the second drive motor 912 drives the second motor screw 913 to rotate, causing the sliding block 914, mounting plate 915 and magnet 92 to move horizontally; when the distance between magnet 92 and reagent kit 7 needs to be adjusted, the linear stepper motor 916 drives magnet mounting base 917 to move up and down, and spring 919 can play a buffering role to avoid damage caused by hard contact between magnet 92 and reagent kit 7, while ensuring that magnet 92 and magnet slide 71 fit tightly together to improve the magnetic field driving effect.

[0032] The second fixing frame 101 of the pressing structure 10 of the present invention is fixed to the upper end face of the inner lower shell 3 by bolts. Multiple second linear stepper motors 102 are installed on the second fixing frame 101 along the length direction of the reagent kit 7. The output shafts of the second linear stepper motors 102 are set vertically downward, and the lower end of each output shaft is fixedly connected to the pressing block 103 by threads.

[0033] The pressure block 103 is made of silicone and its lower end face is designed with an arc shape to fit the pressing part 72 on the reagent kit 7, which can prevent damage to the reagent kit 7 when pressing. Multiple second linear stepper motors 102 can be controlled independently. According to the needs of the reaction process, they drive the pressure block 103 to move up and down according to a preset sequence and stroke to press the corresponding pressing part 72, realizing the quantitative delivery and mixing of multi-channel reagents, meeting the process requirements of complex microfluidic reactions.

[0034] The micropore analysis device of the present invention operates as follows: The drive motor 81 starts, and through the motor screw 82, it drives the reagent kit mounting base 6 to move outward along the slide rail 31 to the pick-up and place position. The operator puts the reagent kit 7 into the mounting slot 64. The drive motor 81 starts in reverse, driving the reagent kit mounting base 6 to reset to the working position and closing the opening and closing door 5.

[0035] The QR code scanner 66 scans the QR code on the reagent kit 7 through the through-hole 65 to obtain information such as reaction temperature and detection program, and the control system automatically matches the corresponding working parameters.

[0036] When the heating element 618 is activated, the temperature sensor 617 monitors the temperature in real time and feeds it back to the control system, stabilizing the reaction environment temperature at the set value.

[0037] According to the preset program, the magnet moving structure 9 drives the magnet 92 to move along the magnet slide 71, and the multiple second linear stepper motors 102 of the pressing structure 10 drive the pressing block 103 to press the pressing part 72. The two driving methods work together to promote reagent mixing and reaction.

[0038] After the reaction is completed, the sample emits light through the light-transmitting hole 611, the dimming hole 691, and the light-passing hole 67 to the photomultiplier tube 68. The lead screw motor 614 adjusts the position of the light adjustment plate 69 to optimize the light intensity. The photomultiplier tube 68 converts the light signal into an electrical signal and transmits it to the control system.

[0039] The control system processes electrical signals and outputs test results. The opening and closing door 5 opens, the reagent kit mounting base 6 moves to the pick-up and drop position, the operator takes out the reagent kit 7, replaces a reagent kit for testing, or the equipment is reset to wait for the next test.

[0040] The above description is merely one embodiment of the present invention and is not intended to limit the invention. Those skilled in the art will recognize that the present invention can be modified and varied in various ways. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A microfluidic analytical device, characterized by, The utility model relates to a portable microfluidic reaction device, including lower shell (1) and outer shell (2), be equipped with inner lower shell (3) and with inner lower shell (3) is connected with the inner upper shell (4) on lower shell (1), inner lower shell (3) is equipped with open and close door (5), inner lower shell (3) inside slidingly equipped with reagent box mounting seat (6), reagent box mounting seat (6) is used for fixing reagent box (7), inner lower shell (3) still is equipped with drive device (8) drive reagent box mounting seat (6) moves in there, Magnet moving structure (9) and press structure (10) are fixedly installed on the upper end surface of inner lower shell (3), and a plurality of press parts (72) and magnet slide (71) are arranged on reagent box (7), magnet moving structure (9) includes second drive device (91) and magnet (92) connected with second drive device (91), second drive device (91) drives magnet (92) to move along magnet slide (71) and promotes microfluidic reaction, and press structure (10) is used for pressing a plurality of press parts (72) to realize microfluidic reaction.

2. The microfluidic analytical device according to claim 1, characterized in that Opposite slide rails (31) are arranged on inner lower shell (3), and slide blocks (61) are arranged on reagent box mounting seat (6) and are slidably connected with slide rails (31). Drive device (8) includes drive motor (81) and motor lead screw (82) connected with drive motor (81), and moving plate (83) is matched on motor lead screw (82), and moving plate (83) is fixedly connected with reagent box mounting seat (6).

3. The microfluidic analytical device according to claim 2, characterized in that Reagent box mounting seat (6) includes base (62) and reagent box positioning block (63) fixedly connected with base (62) on the upper side of base (62), and slide block (61) is detachably fixedly connected with reagent box positioning block (63). Mounting groove (64) is arranged on reagent box positioning block (63), reagent box (7) is placed in mounting groove (64), mounting groove (64) is provided with through hole (65) penetrating reagent box positioning block (63) itself, base (62) has a cavity, two-dimensional code scanner (66) is arranged in the cavity, two-dimensional code scanner (66) is located directly below through hole (65), and two-dimensional code scanner (66) is used for scanning the two-dimensional code of reagent box (7).

4. The microfluidic analytical device according to claim 3, characterized in that Fixing groove (641) and sliding groove (642) are further arranged in mounting groove (64), through light hole (67) is arranged in sliding groove (642) and penetrates reagent box positioning block (63), and photomultiplier (68) is arranged on the lower side of reagent box positioning block (63) and faces through light hole (67); Light adjusting plate (69) is matched and arranged in sliding groove (642), and light adjusting hole (691) is arranged on light adjusting plate (69), fixing plate (610) is arranged at fixing groove (641), and light transmission hole (611) is arranged on fixing plate (610) and is located directly above through light hole (67).

5. The microfluidic analytical device according to claim 4, characterized in that Connecting plate (612) is connected with light adjusting plate (69), guide rail (613) is arranged on the lower side of reagent box positioning block (63), and connecting plate (612) is slidably connected with guide rail (613); Silk rod motor (614), output lead screw (615) and transmission block (616) matched with output lead screw (615) are further arranged on the lower side of reagent box positioning block (63), and transmission block (616) is fixedly connected with connecting plate (612).

6. The microfluidic analytical device according to claim 5, wherein The reagent box positioning block (63) is provided with a temperature sensor (617) on one side, and is further provided with a heating belt (618).

7. The microfluidic analytical device according to claim 1 or 6, characterized in that The second driving device (91) comprises a fixing frame (911) fixed on the inner lower shell (3), a second driving motor (912) and a second motor lead screw (913) installed on the fixing frame (911), the second motor lead screw (913) is cooperatively installed with a sliding block (914), the sliding block (914) is fixed with a mounting plate (915), the mounting plate (915) is installed with a linear stepping motor (916), the linear stepping motor (916) is connected with a magnet mounting seat (917), the magnet mounting seat (917) has a cavity (918), a spring (919) is installed in the cavity (918), the other end of the spring (919) is fixedly connected with a magnet (92), a limiting groove (920) is arranged on the side wall of the cavity (918), and a limiting column (921) is arranged on the magnet (92) and matched with the limiting groove (920).

8. The microfluidic analytical device according to claim 7, characterized in that The pressing structure (10) comprises a second fixing frame (101) fixed on the inner lower shell (3), a plurality of second linear stepping motors (102) installed on the second fixing frame (101), and a pressing block (103) connected with the second linear stepping motors (102).

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