Liquid medicine sampling equipment for pharmaceutical experimental analysis and working method of liquid medicine sampling equipment

Abstract

The invention belongs to the technical field of liquid medicine sampling, and discloses liquid medicine sampling equipment for pharmaceutical experimental analysis and a working method of the liquid medicine sampling equipment. The equipment comprises a hollow sampling circular tube, a driving liquid taking unit is arranged on the sampling circular tube; the driving liquid taking unit comprises a retention base ring which is mounted on the sampling circular tube and is close to the upper end of the sampling circular tube; the upper end of the sampling circular tube is in fit connection with a driving cylinder in a sliding fit manner; the other end of the sampling circular tube is connected with a sampling head in a quick-release manner; opposite inner supporting assemblies are arranged on the retention base ring; the back-to-back inner supporting assembly comprises a displacement lead screw with a driving source. The two displacement lead screws are symmetrically installed on the opposite outer walls of the retention base ring. An annular base is fixedly mounted on the outer wall of the sampling circular tube; a rotary stirring and mixing device is arranged on the annular base and is used for mixing liquid medicine around the input end of the sampling circular tube; according to the invention, the uniformity of samples can be ensured during sampling, and the sampling effect of equipment and the detection precision of pharmaceutical experimental analysis are improved.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical liquid sampling technology, specifically, it relates to a pharmaceutical liquid sampling device and its working method for pharmaceutical experimental analysis. Background Technology

[0002] In pharmaceutical experiments, it is necessary to sample the drug solution to obtain samples for subsequent analysis. There are various existing drug solution sampling devices. For example, Chinese utility model patent with patent application number CN202020457298.X discloses a drug solution sampling device for pharmaceutical experimental analysis, including a drug solution suction cylinder, a pull rod running through the inside of the drug solution suction cylinder, a piston fixedly installed at the bottom of the pull rod, the piston and the inner wall of the suction cylinder being interference fit, a fixing plate fixedly installed at the top of the pull rod, connecting rods on both sides of the bottom of the fixing plate, the top of the connecting rods being rotatably connected to the fixing plate, the lower end of the connecting rods passing through a mounting base, and a turntable fixedly installed on the mounting base.

[0003] When using the aforementioned existing drug sampling equipment, the input end of the drug sampler is first placed into the drug solution for sampling. However, the sampled drug solution is usually in a static state, and the active ingredients in the drug solution are prone to precipitation, which will concentrate at the bottom of the container after settling. If only the upper clear liquid is taken, the measured content of the active ingredient will be lower than the actual value; if only the bottom sediment is taken, the content will be higher than the actual value. The uniformity of the sample cannot be guaranteed during sampling, which not only reduces the sampling effect of the equipment, but also directly reduces the detection accuracy of pharmaceutical experimental analysis. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the prior art and provide a pharmaceutical liquid sampling device and its working method for pharmaceutical experimental analysis. The device can sample pharmaceutical liquid and mix the pharmaceutical liquid around the input end of the sampling tube before sampling, thereby ensuring the uniformity of the pharmaceutical liquid during sampling and improving the sampling effect and detection accuracy of pharmaceutical experimental analysis.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: A pharmaceutical liquid sampling device for pharmaceutical experimental analysis includes a hollow sampling tube; the sampling tube is provided with a driving liquid sampling unit for sampling the pharmaceutical liquid; the driving liquid sampling unit includes a fixing base ring, the inner wall of which is fixedly connected to the outer wall of the sampling tube and is close to the upper end of the sampling tube. The upper end of the sampling tube is fitted with a driving cylinder, and the two are slidably connected; the other end of the sampling tube is connected to a sampling head; the two are quickly detached; the fixed base ring is provided with a back-to-back inner support assembly for fixing the sampling tube in the container containing the drug solution; the back-to-back inner support assembly includes two displacement screws with their own driving sources; the two displacement screws are symmetrically installed on opposite outer walls of the fixed base ring. An annular base is fixedly installed on the outer wall of the sampling tube; the annular base is close to the upper end of the sampling tube; a swirling mixing device is provided on the annular base for mixing the liquid medicine located around the input end of the sampling tube; the swirling mixing device includes a rotating ring rail, the inner wall of which is fixedly connected to the outer wall of the annular base.

[0006] The following are further optimizations of the above technical solution by the present invention: A rotating block is fitted onto the rotating ring rail, and the two slide together; there are several rotating blocks; the tops of several rotating blocks are connected to a rotating toothed ring; a U-shaped square seat is fixedly connected to the side of the rotating block away from the rotating ring rail; a rotating shaft is installed inside the U-shaped square seat; A rotating base block is mounted on the rotating shaft, and a stirring rod is mounted on the bottom of the rotating base block; the initial position of the stirring rod is parallel to the sampling tube; one end of the rotating shaft passes through the outer side of the U-shaped square base and is equipped with a drive gear; the end of the stirring rod extends to the input end of the sampling tube.

[0007] Further optimization: A drive base is fixedly mounted on the retaining base ring; a transmission base plate is fixedly connected to the drive base. A drive shaft is rotatably mounted on the drive base. A drive pulley is mounted on one end of the drive shaft, and a rotary gear is mounted on the other end. The rotary gear meshes with a rotary gear ring. A drive shaft is rotatably mounted on the drive base plate, and a driven pulley is connected to the end of the drive shaft away from the drive base plate; a drive belt is sleeved between the driving pulley and the driven pulley. A positioning gear is also installed on the drive shaft.

[0008] Further optimization: A valve is installed inside the sampling tube and is located at the input end of the sampling tube; A lifting screw is rotatably mounted on the top of the fixed base ring, and a power source is fixedly mounted on the bottom of the fixed base ring; the power output end of the power source is connected to the lifting screw drive. A lifting slide column is also fixedly installed on the top of the fixed base ring, and the lifting slide column is arranged parallel to the lifting screw. A cover plate is fixedly installed at the upper end of the drive cylinder; the upper ends of the lifting slide column and the lifting screw both pass through the cover plate and are fixedly connected to the limit plate; the cover plate slides with the lifting slide column; the cover plate is threaded with the lifting screw.

[0009] Further optimization: A compound angle control module is also provided on the rotating block; the compound angle control module includes a T-shaped base, which is installed at the bottom of the rotating block; The first and second rotating shafts are rotatably mounted on the T-shaped base, and the first and second rotating shafts are arranged perpendicularly. The ends of the first and second rotating shafts that are close to each other are connected by a bevel gear set. The lower end of the first rotating shaft is fixedly connected to a drive gear. The other end of the second rotating shaft is fixedly connected to a positioning turntable.

[0010] Further optimization: An active gear ring is provided on the side of the annular base away from the rotating gear ring; the inner wall of the active gear ring is fixedly connected to the outer wall of the sampling tube; the active gear ring and the active gear are meshed together.

[0011] Further optimization: A positioning column is installed on the edge of the positioning turntable away from the second rotating shaft; Multiple guide columns are slidably connected on the T-shaped base; a positioning block is installed at the upper end of the guide column; the positioning block is located on the side of the positioning turntable away from the second rotating shaft; a positioning groove is opened on the positioning block; the positioning column is located in the positioning groove, and the two slide in fit; a drive rack is installed on the guide column; the drive rack and the drive gear are meshed.

[0012] Further optimization: A displacement base block is threaded onto the displacement screw; a displacement cylinder is fixedly installed on the side of the retaining base ring away from the sampling tube; the displacement cylinder slides through the displacement base block; a positioning rack is installed on the displacement base block; the positioning rack meshes with the positioning gear.

[0013] Further optimizations: A retaining arc block is installed on the displacement base block; the displacement screw is located at the inner diameter of the retaining arc block; a rubber buffer pad is connected to the outer wall of the retaining arc block.

[0014] This invention also provides a method for operating a pharmaceutical liquid sampling device for pharmaceutical experimental analysis. Using the aforementioned pharmaceutical liquid sampling device for pharmaceutical experimental analysis includes the following steps: S1. Place the sampling tube into the container containing the medicine solution to be sampled; and fix the sampling tube in the container by operating the opposing inner support assembly to carry out the sampling operation. S2. Control the drive liquid sampling unit to make the drive cylinder move out and in the sampling tube to draw in the medicine liquid at the input end of the sampling tube and complete the sampling operation of the medicine liquid. S3. The liquid medicine around the input end of the sampling tube is stirred and mixed by a rotary mixing device to avoid uneven sample composition.

[0015] The present invention, by adopting the above technical solution, has at least the following beneficial effects: 1. This invention has the effect of homogenizing the composition of the drug solution around the input end of the sampling tube. This prevents the surrounding drug solution from being static and causing precipitation of the active ingredients, and avoids the active ingredients from concentrating at the bottom of the container. Whether sampling from the upper or lower layer of the drug solution, the sample composition is uniform. This avoids situations where only the upper clear liquid is sampled, resulting in a lower than actual effective ingredient content, or where only the bottom sediment is sampled, resulting in a higher than actual content. Regardless of the depth of the sampling tube within the drug solution, the active ingredients in the sample are uniform. This ensures sample uniformity during sampling, improving not only the sampling effect but also the detection accuracy of pharmaceutical experimental analysis, and reducing the limitations of the sampling method.

[0016] 2. In this invention, the sampling tube is fixedly installed inside the container by operating the opposing inner support assembly for sampling. The two displacement screws of the opposing inner support assembly drive the displacement base block to move the fixed arc block away from the sampling tube until the fixed arc block contacts the inner wall of the container, thus fixing the sampling tube. During this process, the displacement base block simultaneously drives the stirring rod of the vortex mixing device to rotate in a ring around the outer circumference of the sampling tube to mix the medicine around the input end of the sampling tube. This allows the fixing and placement of the sampling tube and the stirring and mixing of the medicine to be completed simultaneously, and the stirring and mixing of the medicine is placed before the sampling operation. This ensures that the medicine is fully mixed during the sampling operation, improving the sampling accuracy and the effectiveness of the sample. Attached Figure Description

[0017] Figure 1 This is a cross-sectional view of the sampling tube in an embodiment of the present invention; Figure 2 This is a schematic diagram of the structure of the driving cylinder in an embodiment of the present invention; Figure 3 This is a schematic diagram of the structure at the position of the positioning rack in an embodiment of the present invention; Figure 4 This is a schematic diagram of the structure at the position of the active toothed ring in an embodiment of the present invention; Figure 5 This is an exploded cross-sectional view of the sampling head in an embodiment of the present invention; Figure 6 This is a schematic diagram of the overall structure in an embodiment of the present invention; Figure 7 This is a schematic diagram of the structure at the position of the drive rack in an embodiment of the present invention; Figure 8 This is an exploded view of the rotating block in an embodiment of the present invention; Figure 9 This is a schematic diagram of the structure at the location of the retaining arc block in an embodiment of the present invention; Figure 10 This is a schematic diagram of the structure at the position of the stirring rod in an embodiment of the present invention; Figure 11 This is a schematic diagram of the structure at the location of the rotating base block in an embodiment of the present invention; Figure 12 This is a schematic diagram of the structure at the position of the rotating toothed ring in an embodiment of the present invention.

[0018] In the diagram: 1-Sampling tube; 2-Fixing base ring; 3-Driving cylinder; 4-Sampling head; 5-Displacement screw; 6-Annular base; 7-Rotating ring rail; 8-Rotating block; 9-Rotating gear ring; 10-U-shaped square seat; 11-Rotating shaft; 12-Rotating base block; 13-Stirring rod; 14-Driving gear; 15-Driving base; 16-Transmission base plate; 17-Driving shaft; 18-Driving pulley; 19-Rotating gear; 20-Transmission shaft; 21-Driven pulley; 22-Transmission belt; 23-Positioning gear; 24- Valve; 25-Lifting screw; 26-Power source; 27-Lifting slide column; 28-Cover plate; 29-T-shaped base; 30-First rotating shaft; 31-Second rotating shaft; 32-First bevel gear; 33-Driving gear; 34-Second bevel gear; 35-Positioning turntable; 36-Driving gear ring; 37-Positioning column; 38-Guide slide column; 39-Positioning rectangular block; 40-Positioning rectangular groove; 41-Drive rack; 42-Displacement base block; 43-Displacement cylinder; 44-Positioning rack; 45-Fixing arc block; 46-Rubber buffer pad. Detailed Implementation

[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0020] Implementation examples, by Figures 1 to 12 As shown, a pharmaceutical experimental analysis drug liquid sampling device includes a hollow sampling tube 1; a driving liquid sampling unit is provided on the sampling tube 1 for drug liquid sampling; the driving liquid sampling unit includes a retaining base ring 2, the inner wall of the retaining base ring 2 is fixedly connected to the outer wall of the sampling tube 1, and is close to the upper end of the sampling tube 1.

[0021] The upper end of the sampling tube 1 is fitted with a driving cylinder 3, and the two are slidably connected; the other end of the sampling tube 1 is connected to a sampling head 4; the two are quickly detached; the fixed base ring 2 is provided with a back-to-back inner support assembly, which is used to fix the sampling tube 1 in the container containing the drug solution; the back-to-back inner support assembly includes two displacement screws 5 with their own driving sources; the two displacement screws 5 are symmetrically installed on the opposite outer walls of the fixed base ring 2.

[0022] An annular base 6 is fixedly installed on the outer wall of the sampling tube 1; the annular base 6 is close to the upper end of the sampling tube 1; a swirling mixing device is provided on the annular base 6 for mixing the liquid medicine located around the input end of the sampling tube 1; the swirling mixing device includes a rotating ring rail 7, the inner wall of the rotating ring rail 7 is fixedly connected to the outer wall of the annular base 6.

[0023] In this embodiment, a valve 24 is installed inside the sampling tube 1 and is located at the input end of the sampling tube 1.

[0024] A lifting screw 25 is rotatably mounted on the top of the fixed base ring 2, and a power source 26 is fixedly mounted on the bottom of the fixed base ring 2; the power output end of the power source 26 is connected to the lifting screw 25 for transmission.

[0025] The top of the fixed base ring 2 is also fixedly installed with a lifting slide column 27, which is arranged parallel to the lifting screw 25.

[0026] A cover plate 28 is fixedly installed on the upper end of the drive cylinder 3; the upper ends of the lifting slide column 27 and the lifting screw 25 both pass through the cover plate 28 and are fixedly connected to the limit plate; the cover plate 28 and the lifting slide column 27 are in sliding fit; the cover plate 28 and the lifting screw 25 are in threaded fit.

[0027] With this design, during use, the sampling tube 1 is first placed into the container holding the medicine to be sampled, with valve 24 in the closed state. This allows the input end of the sampling tube 1 to be immersed in the medicine, while the output end is above the liquid surface. Once the input end of the sampling tube 1 is immersed in the medicine and at the set sampling depth, the power source 26 is activated. The output end of the power source 26 drives the lifting screw 25 to rotate, causing the cover plate 28 on it to move at the lifting slide column 27. The cover plate 28 then drives the drive cylinder 3 to move at the limit within the sampling tube 1. At this moment, the drive cylinder 3 moves away from the input end of the sampling tube 1, thereby drawing the medicine into the sampling tube 1, accelerating the extraction and sampling speed, and improving the sampling efficiency of the sampling equipment.

[0028] Meanwhile, the drug solution drawn into the sampling tube 1 flows through its sampling head 4. The sampling head 4 is used to filter the drug solution to prevent impurities in the drug solution from entering the sampling tube 1 and causing blockage of the channel. At the same time, it also prevents excessive impurities from affecting the detection results and accuracy of subsequent pharmaceutical experimental analysis.

[0029] In this embodiment, the sampling head 4 and the sampling tube 1 are connected by a quick-release mechanism, which facilitates the replacement or maintenance of the sampling head 4. This allows the device to select the appropriate sampling head 4 model according to different sampling needs, so as to achieve different sampling purposes and effects, reduce the limitations of the device in use, and further improve the device's performance.

[0030] In this embodiment, the device can automatically sample the liquid medicine. By setting the lifting screw 25, the movement distance of the cover plate 28 and the driving cylinder 3 can be controlled with high precision, so that the device can extract the required specifications and volume of liquid medicine according to different sampling conditions. This not only reduces the workload of the staff when using the device, but also improves the sampling accuracy.

[0031] Once the sampling operation of the sampling tube 1 is completed, the driving cylinder 3 stops moving. At this time, the sample solution that has been sampled is loaded into the sampling tube 1, which can avoid the problem of the sample spilling or being lost in the sampling tube 1, resulting in the sample volume not matching the experimental volume, and further improves the effectiveness of the equipment.

[0032] The displacement screw 5 is threadedly connected to a displacement base block 42; a displacement cylinder 43 is fixedly installed on the side of the retaining base ring 2 away from the sampling tube 1; the displacement cylinder 43 slides through the displacement base block 42; a positioning rack 44 is installed on the displacement base block 42.

[0033] A retaining arc block 45 is fixedly installed on the displacement base block 42 by two connecting rods; the displacement screw 5 is located at the inner diameter of the retaining arc block 45; a rubber buffer pad 46 is connected to the outer wall of the retaining arc block 45.

[0034] With this design, during use, the sampling tube 1 is placed into the container containing the medicine solution for sampling. At this time, the input end of the sampling tube 1 is already immersed in the medicine solution. After the input end of the sampling tube 1 is placed to the depth of the medicine solution to be sampled, the self-driven source of the displacement screw 5 is activated, causing the displacement screw 5 to drive the threaded displacement base block 42 to move at the upper limit of the displacement cylinder 43. This causes the displacement base block 42 to move away from the sampling tube 1. At the same time, the stationary arc block 45 moves synchronously with the displacement base block 42, causing the stationary arc block 45 to move away from the sampling tube 1, that is, to move closer to the inner wall of the container, until the stationary arc block 45 contacts the inner wall of the container.

[0035] Since there are two displacement screws 5, and the two displacement screws 5 are symmetrically installed on the opposite outer walls of the fixed base ring 2, the two displacement base blocks 42 move in opposite directions. Through the opposite movement of the two fixed arc blocks 45, the outer walls of the two fixed arc blocks 45 are in contact with the corresponding inner walls of the container, and the contact strength can be guaranteed. This allows the sampling tube 1 to be supported in the container at the current height, thus fixing the sampling tube 1 in the container for use. This avoids the need for the staff to hold the sampling tube 1 while waiting for the sampling process, reducing the workload of the staff. At the same time, it prevents the sampling tube 1 from shaking during sampling, which would cause the sampling position and height to change continuously. This allows the sampling tube 1 to be fixed at the current height and position in the container for sampling, preventing the sampled liquid from not meeting the sampling conditions and affecting the detection results of pharmaceutical experimental analysis. This improves the sampling effect of the equipment on the liquid and simultaneously improves the detection accuracy during pharmaceutical analysis.

[0036] In this embodiment, each displacement screw 5 is driven individually, thereby enabling precise control of the moving distance of each fixed arc block 45. By individually controlling the moving distance of each fixed arc block 45, the sampling tube 1 can be fixed at different positions inside the container for use, which allows the device to sample the liquid at different liquid levels, further improving the sampling range of the sampling tube 1 and enhancing the effectiveness of the device.

[0037] When the retaining arc block 45 contacts the inner wall of the container, the rubber buffer pad 46 on the retaining arc block 45 will contact the inner wall of the container. The rubber buffer pad 46 can increase the friction when the retaining arc block 45 contacts the inner wall of the container, and prevent the sampling tube 1 from slipping or dislodging due to insufficient friction when the two retaining arc blocks 45 fix the sampling tube 1 in the container, thus improving the installation effect of the sampling tube 1.

[0038] Meanwhile, the buffering force provided by the rubber buffer pad 46 can reduce the impact force on the sampling tube 1 during use, thereby improving the stability of the sampling tube 1 during sampling and improving the sampling effect and accuracy.

[0039] In this embodiment, the swirling mixing device is disposed on the annular base 6. The swirling mixing device is used to mix the liquid medicine located around the input end of the sampling tube 1, thereby improving the sampling accuracy.

[0040] In this embodiment, a rotating block 8 is fitted onto the rotating ring rail 7 and the two slide together; there are several rotating blocks 8; the tops of several rotating blocks 8 are connected to a rotating toothed ring 9; a U-shaped square seat 10 is fixedly connected to the side of the rotating block 8 away from the rotating ring rail 7; a rotating shaft 11 is installed inside the U-shaped square seat 10.

[0041] A rotating base block 12 is mounted on the rotating shaft 11, and a stirring rod 13 is mounted on the bottom of the rotating base block 12. The initial position of the stirring rod 13 is parallel to the sampling tube 1. One end of the rotating shaft 11 passes through the outer side of the U-shaped square seat 10 and is equipped with a drive gear 14. The end of the stirring rod 13 extends to the input end of the sampling tube 1.

[0042] A drive base 15 is fixedly installed on the fixed base ring 2; a transmission base plate 16 is fixedly connected to the drive base 15, and the other end of the transmission base plate 16 extends to the position of the corresponding displacement base block 42.

[0043] A drive shaft 17 is rotatably mounted on the drive base 15. One end of the drive shaft 17 is equipped with a drive pulley 18, and the other end is equipped with a rotary gear 19. The rotary gear 19 is meshed with the rotary gear ring 9.

[0044] A drive shaft 20 is rotatably mounted on the drive base plate 16, and a driven pulley 21 is connected to the end of the drive shaft 20 away from the drive base plate 16; a drive belt 22 is sleeved between the driving pulley 18 and the driven pulley 21.

[0045] A positioning gear 23 is also installed on the drive shaft 20. The positioning rack 44 is meshed with the positioning gear 23. The displacement screw 5 rotates to drive the displacement block 42 to move the positioning rack 44. The movement of the positioning rack 44 drives the positioning gear 23 to rotate through the meshing of the teeth.

[0046] With this design, when the staff fixes the sampling tube 1 inside the container for sampling, the displacement screw 5 rotates to drive the displacement base block 42 and the fixed arc block 45 to move. During this process, the displacement base block 42 synchronously drives the positioning rack 44 on it to move. When the positioning rack 44 moves, it drives the meshing positioning gear 23 to rotate. The positioning gear 23 drives the driven pulley 21 to rotate synchronously through the transmission shaft 20. The driven pulley 21 drives the driving pulley 18 to rotate through the transmission belt 22. The driving pulley 18 drives the rotating gear 19 to rotate under the action of the drive shaft 17. The rotating gear 19 drives the rotating gear ring 9 that meshes with it to rotate, so that the rotating gear ring 9 rotates at the upper limit of the rotating ring rail 7 through several rotating blocks 8.

[0047] A stirring rod 13 is installed on the rotating block 8. When the rotating blocks 8 rotate at the upper limit of the rotating ring rail 7, they simultaneously drive the stirring rods 13 to rotate around the sampling tube 1. The stirring rods 13 extend to the input end of the sampling tube 1. At this time, the stirring rods 13 rotate to stir and mix the liquid around the input end of the sampling tube 1.

[0048] Several stirring rods 13 continuously stir the liquid, which can rotate the liquid and stir up the liquid components that have settled to the bottom, thus preventing the components in the liquid from settling and causing uneven sample composition during sampling by the sampling tube 1, which would affect the accuracy of subsequent liquid analysis.

[0049] In this embodiment, the end of the stirring rod 13 furthest from the U-shaped square base 10 extends to the input end of the sampling tube 1. This ensures that the stirring rod 13 operates around the input end of the sampling tube 1, preventing ineffective operation or an excessively large range that would result in uneven mixing of the drug solution at the input end of the sampling tube 1. This allows the device to be used by placing the input end of the sampling tube 1 into the drug solution for sampling, preventing the drug solution around the sampling area from being static and causing precipitation of the active ingredients, and preventing the active ingredients from accumulating at the bottom of the container. This ensures that the sample composition is uniform regardless of whether the sampling tube 1 is taken from the upper or lower layer of the drug solution. It avoids the problem of taking only the upper clear liquid, resulting in a lower measured effective ingredient content than the actual value, or taking only the bottom sediment, resulting in a higher content than the actual value. This ensures the uniformity of the sample during sampling, improving not only the sampling effect but also the detection accuracy of pharmaceutical experimental analysis, thus enhancing the overall effectiveness of the device.

[0050] In this embodiment, when the device is in use, the sampling tube 1 is first fixed in the container. During the fixing operation, the stirring rod 13 is synchronously driven to rotate in a circle along the sampling tube 1 to stir the medicine liquid so that it is mixed evenly. Then, the liquid sampling unit is driven to perform the sampling operation of the medicine liquid.

[0051] The rotating block 8 is also equipped with a re-motion angle control module; the re-motion angle control module includes a T-shaped base 29, which is fixedly installed at the bottom of the rotating block 8 by a connecting rod. One end of the connecting rod is fixedly connected to the T-shaped base 29, and the other end of the connecting rod is fixedly connected to the bottom of the rotating block 8.

[0052] A first rotating shaft 30 and a second rotating shaft 31 are rotatably mounted on the T-shaped base 29, and the first rotating shaft 30 and the second rotating shaft 31 are arranged vertically. The ends of the first rotating shaft 30 and the second rotating shaft 31 that are close to each other are connected by a bevel gear set. The lower end of the first rotating shaft 30 is fixedly connected to a drive gear 33. The other end of the second rotating shaft 31 is fixedly connected to a positioning turntable 35.

[0053] The bevel gear set includes a first bevel gear 32 and a second bevel gear 34. The first bevel gear 32 is fixedly installed on the upper end of the first rotating shaft 30, and the second bevel gear 34 is fixedly installed on the end of the second rotating shaft 31 near the first rotating shaft 30. The first bevel gear 32 and the second bevel gear 34 are meshed together.

[0054] An active gear ring 36 is provided on the side of the annular base 6 away from the rotating gear ring 9; the inner wall of the active gear ring 36 is fixedly connected to the outer wall of the sampling tube 1; the active gear ring 36 and the active gear 33 are meshed together.

[0055] A positioning column 37 is installed on the edge of the positioning turntable 35 away from the second rotating shaft 31.

[0056] Multiple guide pins 38 are slidably disposed on the T-shaped base 29; a positioning block 39 is installed on the upper end of the guide pin 38; the positioning block 39 is located on the side of the positioning turntable 35 away from the second rotating shaft 31; a positioning groove 40 is opened on the positioning block 39; the positioning column 37 is located in the positioning groove 40, and the two are slidably engaged; a drive rack 41 is installed on the guide pin 38; the drive rack 41 and the drive gear 14 are meshed and connected.

[0057] When several rotating blocks 8 rotate on the rotating ring rail 7, the T-shaped base 29 on the rotating blocks 8 rotates around the sampling tube 1. The T-shaped base 29 is equipped with a drive gear 33 via the first rotating shaft 30. The drive gear 33 meshes with the drive gear ring 36. When the drive gear 33 on the T-shaped base 29 rotates with the rotating blocks 8 on the rotating ring rail 7, it rotates around the sampling tube 1, causing the drive gear 33 to rotate. The drive gear 33 drives the first bevel gear 32 to rotate via the first rotating shaft 30. The first bevel gear 32 meshes with the second bevel gear 34, driving the second rotating shaft 31 and the positioning turntable 35 to rotate. At this time, the positioning turntable 35 drives the positioning column 37 to move back and forth within the positioning rectangular groove 40, thereby driving the positioning rectangular block 39 to move back and forth within the upper limit of the T-shaped base 29 via the guide slide column 38. At this time, the guide slide column 38 drives the drive rack 41 to move back and forth.

[0058] The drive rack 41 meshes with the drive gear 14 and rotates back and forth. The drive gear 14 drives the rotating shaft 11 to rotate on the U-shaped square seat 10. The rotating shaft 11 drives the rotating base block 12 and the stirring rod 13 to swing back and forth, so that the stirring rod 13 swings continuously away from or towards the sampling tube 1.

[0059] At this time, several stirring rods 13 rotate around the sampling tube 1. The above operation makes the stirring rods 13 reciprocate while rotating around the sampling tube 1, which is used to increase the working range of the stirring rods 13, thereby expanding the mixing range of the medicine and further improving the mixing effect of the medicine and the uniformity of the components in the medicine.

[0060] In this embodiment, the reciprocating swing of the stirring rod 13 is based on the mixed medicine solution, and the initial position of the stirring rod 13 is parallel to the sampling tube 1, so that it can smoothly enter the container containing the medicine solution, avoiding the stirring rod 13 from bursting open and occupying a large space, which would make it difficult to enter. This improves the convenience of sampling when the sampling tube 1 is used, and at the same time reduces the sampling limitations of the equipment.

[0061] This invention also provides a method for operating a pharmaceutical liquid sampling device for pharmaceutical experimental analysis, comprising the following steps: S1. Place the sampling tube 1 into the container containing the medicine to be sampled; and fix the sampling tube 1 in the container by operating the back-to-back inner support assembly to perform the sampling operation.

[0062] In step S1, the working principle of the opposing inner support assembly is as follows: the drive source of the two displacement screws 5 is activated, causing the displacement screws 5 to rotate and drive the threaded displacement base block 42 to move at the upper limit of the displacement cylinder 43. At this time, the displacement base block 42 moves away from the sampling tube 1, and the fixed arc block 45 moves synchronously with the displacement base block 42, so that the fixed arc block 45 moves away from the sampling tube 1 until the fixed arc block 45 drives the rubber buffer pad 46 to contact the inner wall of the container, thereby fixing the sampling tube 1 inside the container.

[0063] S2. Control the driving liquid sampling unit so that the driving cylinder 3 moves out of the sampling tube 1 to extract the liquid medicine at the input end of the sampling tube 1 and complete the sampling operation of the liquid medicine.

[0064] In step S2, the working principle of the liquid extraction unit is as follows: after the input end of the sampling tube 1 is inserted into the liquid and the sampling depth is adjusted, the power source 26 is started. The output end of the power source 26 drives the lifting screw 25 to rotate. The lifting screw 25 drives the cover plate 28 to move at the upper limit of the lifting slide column 27 through the thread. At this time, the cover plate 28 drives the driving cylinder 3 to move at the limit within the sampling tube 1. At this moment, the driving cylinder 3 moves away from the input end of the sampling tube 1, thereby extracting the liquid into the sampling tube 1 for convenient use.

[0065] S3. The liquid medicine around the input end of the sampling tube 1 is stirred and mixed by a rotary mixing device to avoid uneven sample composition.

[0066] The working principle of the swirling mixing device in step S3 is as follows: During the process of the displacement screw 5 rotating to drive the displacement base block 42 and the fixed arc block 45 to move, the displacement base block 42 synchronously drives the positioning rack 44 on it to move. When the positioning rack 44 moves, it will drive the meshing positioning gear 23 to rotate. The positioning gear 23 synchronously drives the driven pulley 21 to rotate through the transmission shaft 20. The driven pulley 21 drives the driving pulley 18 to rotate through the transmission belt 22. Under the action of the drive shaft 17, the driving pulley 18... The rotating gear 19 is driven to rotate, which in turn drives the rotating gear ring 9 that meshes with it to rotate. This causes the rotating gear ring 9 to rotate at its upper limit on the rotating ring rail 7 via several rotating blocks 8. A stirring rod 13 is installed on each rotating block 8. When the rotating blocks 8 rotate at their upper limit on the rotating ring rail 7, they simultaneously drive the stirring rods 13 to rotate around the sampling tube 1. At this time, the stirring rods 13 rotate to mix the liquid around the input end of the sampling tube 1, making it convenient to use.

[0067] When several rotating blocks 8 rotate on the rotating ring rail 7, the rotating blocks 8 drive the T-shaped base 29 to rotate around the sampling tube 1. At this time, the driving gear 33 rotates under the cooperation of the driving gear ring 36. The driving gear 33 drives the first bevel gear 32 to rotate through the first rotating shaft 30. The first bevel gear 32 meshes with the second bevel gear 34 and drives the positioning turntable 35 to rotate through the transmission action of the second rotating shaft 31. The positioning turntable 35 drives the positioning column 37 to move back and forth within the positioning rectangular groove 40, thereby realizing the driving of the positioning rectangular block 3. 9. The guide slide column 38 moves back and forth at the upper limit of the T-shaped base 29. At this time, the guide slide column 38 drives the drive rack 41 to move back and forth. The drive rack 41 meshes with the drive gear 14 to drive the rotating shaft 11 and the rotating base block 12 to rotate back and forth, thereby driving the stirring rod 13 to swing back and forth. When the stirring rod 13 rotates around the sampling tube 1, it is still in a reciprocating swing state, which is used to increase the working range of the stirring rod 13, so as to expand the mixing range of the medicine liquid, further improve the mixing effect of the medicine liquid, and improve the uniformity of the components in the medicine liquid.

[0068] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical liquid sampling device for pharmaceutical experimental analysis, comprising a hollow sampling tube (1); characterized in that: The sampling tube (1) is provided with a driving liquid sampling unit for sampling liquid; the driving liquid sampling unit includes a fixed base ring (2), the inner wall of the fixed base ring (2) is fixedly connected to the outer wall of the sampling tube (1), and is close to the upper end of the sampling tube (1); The upper end of the sampling tube (1) is fitted with a driving cylinder (3), and the two are slidably connected; the other end of the sampling tube (1) is connected with a sampling head (4); the two are quickly connected; the fixed base ring (2) is provided with a back-to-back inner support assembly, which is used to fix the sampling tube (1) in the container containing the drug solution; the back-to-back inner support assembly includes two displacement screws (5) with their own driving sources; the two displacement screws (5) are symmetrically installed on the opposite outer walls of the fixed base ring (2); An annular base (6) is fixedly installed on the outer wall of the sampling tube (1); the annular base (6) is close to the upper end of the sampling tube (1); a swirling mixing device is provided on the annular base (6) for mixing the liquid medicine located around the input end of the sampling tube (1); the swirling mixing device includes a rotating ring rail (7), the inner wall of the rotating ring rail (7) is fixedly connected to the outer wall of the annular base (6).

2. The pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 1, characterized in that: A rotating block (8) is fitted onto the rotating ring rail (7), and the two are in sliding fit; there are several rotating blocks (8); the tops of several rotating blocks (8) are connected to a rotating toothed ring (9); a U-shaped square seat (10) is fixedly connected to the side of the rotating block (8) away from the rotating ring rail (7); a rotating shaft (11) is installed inside the U-shaped square seat (10); A rotating base block (12) is installed on the rotating shaft (11), and a stirring rod (13) is installed at the bottom of the rotating base block (12); the initial position of the stirring rod (13) is parallel to the sampling tube (1); one end of the rotating shaft (11) passes through the outer side of the U-shaped square seat (10) and is equipped with a drive gear (14); the end of the stirring rod (13) extends to the input end of the sampling tube (1).

3. The pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 2, characterized in that: A drive base (15) is fixedly mounted on the fixed base ring (2); a transmission base plate (16) is fixedly connected to the drive base (15). A drive shaft (17) is rotatably mounted on the drive base (15). One end of the drive shaft (17) is equipped with a drive pulley (18), and the other end is equipped with a rotary gear (19). The rotary gear (19) meshes with the rotary gear ring (9). A drive shaft (20) is rotatably mounted on the drive base plate (16), and a driven pulley (21) is connected to the end of the drive shaft (20) away from the drive base plate (16); a drive belt (22) is sleeved between the drive pulley (18) and the driven pulley (21). A positioning gear (23) is also installed on the drive shaft (20).

4. The pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 3, characterized in that: A valve (24) is installed inside the sampling tube (1) and is located at the input end of the sampling tube (1); A lifting screw (25) is rotatably mounted on the top of the fixed base ring (2), and a power source (26) is fixedly mounted on the bottom of the fixed base ring (2); the power output end of the power source (26) is connected to the lifting screw (25) for transmission. The top of the fixed base ring (2) is also fixedly installed with a lifting slide column (27), which is arranged parallel to the lifting screw (25); A cover plate (28) is fixedly installed on the upper end of the driving cylinder (3); the upper ends of the lifting slide column (27) and the lifting screw (25) both pass through the cover plate (28) and are fixedly connected to the limit plate; the cover plate (28) slides with the lifting slide column (27); the cover plate (28) is threaded with the lifting screw (25).

5. A pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 4, characterized in that: The rotating block (8) is also equipped with a compound angle control module; the compound angle control module includes a T-shaped base (29), which is installed at the bottom of the rotating block (8); The first rotating shaft (30) and the second rotating shaft (31) are rotatably mounted on the T-shaped base (29). The first rotating shaft (30) and the second rotating shaft (31) are arranged vertically. The ends of the first rotating shaft (30) and the second rotating shaft (31) that are close to each other are connected by a bevel gear set. The lower end of the first rotating shaft (30) is fixedly connected to a drive gear (33). The other end of the second rotating shaft (31) is fixedly connected to a positioning turntable (35).

6. The pharmaceutical liquid sampling device for pharmaceutical experimental analysis according to claim 5, characterized in that: An active gear ring (36) is provided on the side of the annular base (6) away from the rotating gear ring (9); the inner wall of the active gear ring (36) is fixedly connected to the outer wall of the sampling tube (1); the active gear ring (36) and the active gear (33) are meshed together.

7. A pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 6, characterized in that: A positioning column (37) is installed on the edge of the positioning turntable (35) away from the second rotating shaft (31). Multiple guide pins (38) are slidably arranged on the T-shaped base (29); a positioning block (39) is installed on the upper end of the guide pin (38); the positioning block (39) is located on the side of the positioning turntable (35) away from the second rotating shaft (31); a positioning groove (40) is opened on the positioning block (39); the positioning column (37) is located in the positioning groove (40), and the two are slidably engaged; a drive rack (41) is installed on the guide pin (38); the drive rack (41) and the drive gear (14) are meshed and connected.

8. A pharmaceutical liquid sampling device for pharmaceutical experimental analysis according to claim 7, characterized in that: The displacement screw (5) is threaded with a displacement base block (42); the fixed base ring (2) is fixedly installed with a displacement cylinder (43) on the side away from the sampling tube (1); the displacement cylinder (43) slides through the displacement base block (42); a positioning rack (44) is installed on the displacement base block (42); the positioning rack (44) is meshed with the positioning gear (23).

9. A pharmaceutical solution sampling device for pharmaceutical experimental analysis according to claim 8, characterized in that: A retaining arc block (45) is installed on the displacement base block (42); the displacement screw (5) is located at the inner diameter of the retaining arc block (45); a rubber buffer pad (46) is connected to the outer wall of the retaining arc block (45).

10. A method for operating a pharmaceutical liquid sampling device for pharmaceutical experimental analysis, using the pharmaceutical liquid sampling device for pharmaceutical experimental analysis as described in any one of claims 1-9, characterized in that: Includes the following steps: S1. Place the sampling tube (1) into the container containing the medicine liquid to be sampled; and fix the sampling tube (1) in the container by operating the back-to-back inner support assembly to carry out the sampling operation. S2. Control the driving liquid sampling unit so that the driving cylinder (3) moves out of the sampling tube (1) to extract the liquid medicine at the input end of the sampling tube (1) and complete the sampling operation of the liquid medicine. S3. The liquid medicine around the input end of the sampling tube (1) is stirred and mixed by a rotary mixing device to avoid uneven sample composition.

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