Blending device and sample analyzer

Abstract

The invention provides a uniform mixing device and a sample analyzer, the uniform mixing device comprises: a uniform mixing unit for carrying a sample container, the sample container forming an accommodating cavity, the uniform mixing unit being used for uniformly mixing a to-be-mixed sample in the accommodating cavity; the control unit is electrically connected with the uniform mixing unit, and the control unit is used for acquiring the bottom position of the accommodating cavity and selecting the uniform mixing mode matched with the bottom position of the accommodating cavity, so that the uniform mixing unit performs uniform mixing operation on the to-be-uniformly-mixed sample in the accommodating cavity according to the matched uniform mixing mode. The mixing operation can be carried out by using one mixing unit in a mixing mode matched with the bottom position of the accommodating cavity, other structures do not need to be additionally arranged, and the situation that a detection result has large deviation due to the fact that the sample is not fully mixed and the wall hanging phenomenon of the sample is serious can be avoided, so that the detection accuracy is improved. Meanwhile, the contact between the sample to be uniformly mixed and the anticoagulant can be reduced, so that the detection result is more accurate.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a mixing device and a sample analyzer. BACKGROUND

[0002] In the diagnosis and treatment of diseases, the analysis results obtained by analyzing the patient's sample provide an important reference for clinical diagnosis. For example, blood sample detection is a process of collecting human blood samples and then analyzing and detecting various components in the blood sample to help diagnose diseases or assess health status. In order to prevent blood coagulation, an anticoagulant-containing blood collection tube is usually used when collecting a blood sample. Blood is composed of blood cells and plasma. Due to the different specific gravities of blood cells and plasma, the anticoagulated blood will stratify after standing for a period of time. Therefore, the blood sample needs to be fully mixed before analysis and detection, otherwise the detection results will have large deviations.

[0003] In the prior art, the blood sample is usually mixed by oscillation or rotation. Regardless of which mixing method is used, when the mixing intensity is too small, the sample will not be mixed sufficiently, resulting in large deviations in the detection results. When the mixing intensity is too large, the "wall-hanging phenomenon" of the sample will be more serious, resulting in a large reduction in the sample amount for detection, which also leads to large deviations in the detection results. SUMMARY

[0004] The present application provides a mixing device and a sample analyzer, which can avoid the situation that the sample is not mixed sufficiently and the "wall-hanging phenomenon" of the sample is more serious, resulting in large deviations in the detection results. At the same time, the present application can also reduce the contact between the sample to be mixed and the anticoagulant, so that the detection results are more accurate.

[0005] To solve the above technical problems, one technical solution adopted by the present application is to provide a mixing device, which comprises: a mixing unit for carrying a sample container, the sample container being formed with a receiving cavity, the mixing unit being used for mixing the sample to be mixed in the receiving cavity; and a control unit electrically connected with the mixing unit, the control unit being used for acquiring the bottom position of the receiving cavity and selecting a mixing mode matched with the bottom position of the receiving cavity, so that the mixing unit mixes the sample to be mixed in the receiving cavity according to the matched mixing mode.

[0006] In one specific embodiment, the mixing device further comprises a sampling unit, the sampling unit comprising a sampling driving mechanism and a sampling needle, the sampling driving mechanism being connected with the sampling needle to drive the sampling needle to insert into the receiving cavity, and the control unit being electrically connected with the sampling driving mechanism to determine the bottom position of the receiving cavity according to the movement distance of the sampling needle.

[0007] In an embodiment, the mixing unit comprises a centrifugal motor and a mixing seat, the mixing seat is used to carry the sample container and is connected with the output shaft of the centrifugal motor, so that the centrifugal motor drives the sample container to centrifugally mix the sample to be mixed.

[0008] In an embodiment, the control unit is used to select a mixing mode matched with the movement distance of the sampling needle.

[0009] In an embodiment, the control unit is further used to determine the depth of the containing cavity according to the bottom position of the containing cavity, and select a mixing mode matched with the depth of the containing cavity.

[0010] In an embodiment, the control unit is further used to obtain the position of the rotation center of the mixing seat, and calculate the interval distance between the position of the rotation center and the bottom position of the containing cavity, so that the control unit selects a mixing mode matched with the interval distance.

[0011] In an embodiment, the mixing device further comprises a sample feeding unit, the sample feeding unit is used to sequentially feed a plurality of sample containers, the control unit is used to obtain the bottom position of the containing cavity of the first sample container, and select a mixing mode matched with the bottom position of the containing cavity of the first sample container, so that the mixing unit mixes the samples to be mixed in a preset number of sample containers according to the matched mixing mode.

[0012] In an embodiment, the mixing device further comprises a transfer unit, the transfer unit is used to transfer the sample container on the sample feeding unit to the mixing unit.

[0013] In an embodiment, the mixing mode comprises a mixing strength and a mixing time.

[0014] To solve the above technical problems, another technical scheme adopted by the present application is to provide a sample analyzer, the sample analyzer comprises a detection device and the mixing device, and the detection device is used to detect the mixed sample to be mixed.

[0015] The beneficial effects of the present application are: different from the prior art, the mixing device provided by the present application comprises: a mixing unit for carrying a sample container, the sample container is formed with a containing cavity, and the mixing unit is used for mixing the sample to be mixed in the containing cavity; a control unit electrically connected with the mixing unit, the control unit is used for acquiring the bottom position of the containing cavity, and selecting a mixing mode matched with the bottom position of the containing cavity, so that the mixing unit mixes the sample to be mixed in the containing cavity according to the matched mixing mode. Through this setting mode, for different sample containers, one mixing unit can be used to mix the sample by the mixing mode matched with the bottom position of the containing cavity, without the need to additionally increase other structures, and the situation that the sample mixing is insufficient and the sample appears more serious "wall hanging phenomenon", resulting in large deviation of the detection result can be avoided, at the same time, the contact of the sample to be mixed with the anticoagulant can be reduced, so that the detection result is more accurate. BRIEF DESCRIPTION OF DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0017] Figure 1 is a top view structural schematic diagram of the mixing device provided by the present application; Figure 2 is a control schematic diagram of the mixing device in the embodiment; Figure 1 is a perspective structural schematic diagram of the mixing unit in the embodiment; Figure 3 Figure 1 is a sectional schematic diagram of the mixing unit in the embodiment; Figure 4 is a sectional schematic diagram of the sample container in the embodiment; Figure 3 is a sectional schematic diagram of the sample container in another embodiment of the embodiment; Figure 5 Figure 4 is a perspective structural schematic diagram of the sampling unit in the embodiment; Figure 6 is a front view schematic diagram of the container rack in the embodiment. Figure 1 is a front view schematic diagram of the container rack in the embodiment. Figure 7 Figure 1 is a front view schematic diagram of the container rack in the embodiment. DETAILED DESCRIPTION

[0018] ​​​The application will be described in further detail below with reference to the drawings and embodiments. It is to be particularly noted that the following embodiments are merely intended to illustrate the application, but not to limit the scope of the application. Similarly, the following embodiments are only some, but not all of the embodiments of the application, and all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of the application.

[0019] The terms "first", "second", "third" in the present application are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "second", "third" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is at least two, such as two, three, etc., unless otherwise specifically limited. All directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present application are only used to explain the relative positional relationship, movement condition, etc. between the components in a certain posture (as shown in the drawings), and if the certain posture changes, the directional indications also change accordingly. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device including a series of steps or units is not limited to the listed steps or units, but can optionally include steps or units not listed, or can optionally include other steps or units inherent to the process, method, product or device.

[0020] In this document, reference to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are they necessarily mutually exclusive or alternative embodiments. It is expressly understood that the embodiments described herein are merely examples from a whole class of comparable embodiments which those skilled in the art will readily appreciate. It is also expressly understood that the application has hundreds of possible combinations of embodiments, and that the scope of the application is not limited to the specific embodiments described herein.

[0021] Please refer to Figure 1 and Figure 2 , Figure 1 is a top view structural schematic diagram of an embodiment of the mixing device 10 provided by the present application, Figure 2 is Figure 1 a control schematic diagram of the mixing device 10 in

[0022] Please refer to Figure 3 and Figure 4 , Figure 3 is Figure 1 a three-dimensional structural schematic diagram of the mixing unit 11 inFigure 4 is Figure 3 is a sectional view of a mixing unit 11 for carrying a sample container 110, the sample container 110 is formed with a containing cavity 101, the mixing unit 11 is used for mixing a sample 120 to be mixed in the containing cavity 101.

[0023] Specifically, the mixing unit 11 includes a centrifugal motor 111 and a mixing seat 112, the mixing seat 112 is used for carrying the sample container 110 and is connected with an output shaft of the centrifugal motor 111, so that the centrifugal motor 111 drives the sample container 110 to centrifugally mix the sample 120 to be mixed, that is, in the embodiment, the mixing unit 11 adopts a rotational mixing mode, in other embodiments, the mixing unit 11 can also adopt other mixing modes, such as oscillation mixing.

[0024] Please refer to Figure 4 , Figure 5 and Figure 6 , Figure 5 is Figure 4 is a sectional view of another embodiment of the sample container 110, Figure 6 is Figure 1 is a perspective view of a sampling unit 13, the control unit 12 is electrically connected with the mixing unit 11, in the embodiment, that is, the control unit 12 is electrically connected with the centrifugal motor 111, the control unit 12 is used for acquiring a bottom position of the containing cavity 101.

[0025] Specifically, the mixing device 10 in the embodiment further includes the sampling unit 13, the sampling unit 13 includes a sampling driving mechanism 131 and a sampling needle 132, the sampling driving mechanism 131 is connected with the sampling needle 132 to drive the sampling needle 132 to insert into the containing cavity 101, the control unit 12 is electrically connected with the sampling driving mechanism 131, so as to determine the bottom position of the containing cavity 101 according to a movement distance of the sampling needle 132.

[0026] In actual application, the control unit 12 controls the sampling driving mechanism 131 to drive the sampling needle 132 to insert into the containing cavity 101 from an initial position A, when the sampling needle 132 inserts into the bottom position of the containing cavity 101, the sampling needle 132 and the bottom position of the containing cavity 101 stop, at this time, the current will become larger, the control unit 12 can determine that the sampling needle 132 has moved to the bottom position of the containing cavity 101, for example, as shown in Figure 4 , the control unit 12 determines the bottom position B1 of the containing cavity 101a of the sample container 110a according to the movement distance L11 of the sampling needle 132 from the initial position A, as shown in Figure 5The control unit 12 shown determines the bottom position B2 of the containing cavity 101b of the sample container 110b according to the movement distance L21 of the sampling needle 132 from the initial position A.

[0027] Further, the control unit 12 also selects a mixing mode matching the bottom position of the containing cavity 101, so that the mixing unit 11 mixes the sample 120 in the containing cavity 101 according to the matching mixing mode. In this way, for different sample containers 110, one mixing unit 11 can mix the sample according to the mixing mode matching the bottom position of the containing cavity, without the need to additionally increase other structures, and can avoid the situation that the sample mixing is insufficient and the sample "wall hanging phenomenon" is more serious, which leads to a large deviation of the detection result. At the same time, it can also reduce the contact of the sample to be mixed with the anticoagulant, so that the detection result is more accurate.

[0028] Specifically, in this embodiment, the mixing mode includes mixing strength and mixing time. For example, if the mixing unit 11 adopts a rotating mixing mode, the mixing strength can be the rotating speed of the centrifugal motor 111. For another example, if the mixing unit 11 adopts a shaking mixing mode, the mixing strength can be the shaking amplitude of the shaking motor.

[0029] For the convenience of description, in this embodiment, the mixing unit 11 is taken as an example in a rotating mixing mode: In a specific application scenario, the control unit 12 is configured to select a mixing mode matching the movement distance of the sampling needle 132.

[0030] For example, as shown in Figure 4 For the sample container 110a, the control unit 12 selects a mixing mode matching the movement distance L11 of the sampling needle 132, as shown in Figure 5As shown, for the sample container 110b, the control unit 12 selects the mixing mode matching the movement distance L21 of the sampling needle 132. It can be obviously seen that L11>L21, that is, the bottom position B1 of the containing cavity 101a is lower than the bottom position B2 of the containing cavity 101b, and the interval distance L31 between the bottom position B1 of the containing cavity 101a and the position C of the rotation center P of the mixing seat 112 is greater than the interval distance L32 between the bottom position B2 of the containing cavity 101b and the position C of the rotation center P of the mixing seat 112. Therefore, when the centrifugal motor 111 drives the mixing seat 112 to rotate, the centrifugal force received by the sample 120 to be mixed in the containing cavity 101a is greater than the centrifugal force received by the sample 120 to be mixed in the containing cavity 101b. In order to achieve the mixing effect of “sufficient mixing and reducing the severity of wall hanging”, the mixing intensity (the rotation speed of the centrifugal motor 111) required by the sample 120 to be mixed in the containing cavity 101a is smaller than the mixing intensity required by the sample 120 to be mixed in the containing cavity 101b under the same mixing time, or the mixing time required by the sample 120 to be mixed in the containing cavity 101a is smaller than the mixing time required by the sample 120 to be mixed in the containing cavity 101b under the same mixing intensity. Therefore, for different sample containers 110, different mixing intensities and / or different mixing times can be set in advance, that is, different mixing modes are set in advance, so that the samples 120 to be mixed in different sample containers 110 can all achieve the mixing effect of “sufficient mixing and no wall hanging”, and different mixing modes are associated with the movement distances of the sampling needle 132. When actually applied, the control unit 12 can select the matching mixing mode according to the movement distance of the sampling needle 132 in the association relationship.

[0031] In another specific application scenario, the control unit 12 is further configured to determine the depth of the containing cavity 101 according to the bottom position of the containing cavity 101, and select a mixing mode matching the depth of the containing cavity 101.

[0032] Specifically, the distance L12 between the initial position A of the sampling needle 132 and the sample container 110 (the sample container 110a and the sample container 110b) can be stored in the control unit 12 in advance, as shown in the following table. Figure 4 and Figure 5As shown, when the control unit 12 obtains the bottom position B1 of the containing cavity 101a and the bottom position B2 of the containing cavity 101b, the depth of the sample container 110a and the sample container 110b is calculated according to the movement distance L11 and L21 of the sampling needle 132, that is, the depth L13 of the sample container 110a is L11-L12, and the depth L23 of the sample container 110b is L21-L12. It can be seen that L13>L23, so the interval distance L31 between the bottom position B1 of the containing cavity 101a and the position C of the rotation center P of the mixing seat 112 is greater than the interval distance L32 between the bottom position B2 of the containing cavity 101b and the position C of the rotation center P of the mixing seat 112. The principle described in the above specific application scenario is the same, and different mixing modes are associated with the depths of the containing cavities 101 of different sample containers 110. When actually applied, the control unit 12 can select a matching mixing mode according to the depth of the containing cavity 101 in the association relationship.

[0033] In yet another specific application scenario, the control unit 12 is further configured to obtain the rotation center position C of the mixing seat 112 and calculate the interval distance between the rotation center position C and the bottom position of the containing cavity 101, so that the control unit 12 selects a mixing mode matched with the interval distance.

[0034] Specifically, the distance L14 between the initial position A of the sampling needle 132 and the rotation center position C of the mixing seat 112 can be pre-stored in the control unit 12, as shown in Figure 4 and Figure 5 As shown, when the control unit 12 obtains the bottom position B1 of the containing cavity 101a and the bottom position B2 of the containing cavity 101b, the interval distance L31 between the rotation center position C and the bottom position B1 of the containing cavity 101a and the interval distance L32 between the rotation center position C and the bottom position B2 of the containing cavity 101b are calculated according to the movement distance L11 and L21 of the sampling needle 132, that is, L31=L11-L14, and L32=L21-L14. It can be seen that L31>L32, that is, the interval distance L31 between the bottom position B1 of the containing cavity 101a and the position C of the rotation center P of the mixing seat 112 is greater than the interval distance L32 between the bottom position B2 of the containing cavity 101b and the position C of the rotation center P of the mixing seat 112. The principle described in the above specific application scenario is the same, and different mixing modes are associated with different interval distances. When actually applied, the control unit 12 can select a matching mixing mode according to the different interval distances in the association relationship.

[0035] As shown in the following table, Table 1 is an experimental data table of the 80 μl sample to be mixed in each sample container 110, and Table 2 is an experimental data table of the 300 μl sample to be mixed in each sample container 110. Through the experimental data in Table 1 and Table 2, it can be clearly seen that the sample to be mixed 120 after mixing by the mixing device 10 in the embodiment meets the detection requirements for sample containers 110 with different bottom positions: Table 1 Table 2 It should be noted that the rotation center P described above is a "virtual center" defined for convenience of description.

[0036] It can be understood that when the mixing unit 11 mixes the sample to be mixed 120, the sampling unit 13 collects the sample to be mixed 120 after mixing to perform subsequent detection operations.

[0037] Please refer to Figure 1 and Figure 7 , Figure 7 is Figure 1 the front view of the container rack 130. The mixing device 10 in the embodiment further includes a sample feeding unit 14. The sample feeding unit 14 is used to sequentially feed a plurality of sample containers 110. In actual application, the plurality of sample containers 110 can be carried on the container rack 130. The sample feeding unit 14 feeds the container rack 130 to complete the sample feeding operation of the plurality of sample containers 110.

[0038] Further, the control unit 12 is used to obtain the bottom position of the containing cavity 101 of the first sample container 110, and select a mixing mode matched with the bottom position of the containing cavity 101 of the first sample container 110, so that the mixing unit 11 mixes the sample to be mixed 120 in the preset number of sample containers 110 according to the matched mixing mode.

[0039] For example, the preset number in the embodiment is 10, which indicates that the bottom positions of the containing cavities 101 of the 10 sample containers 110 are the same. Therefore, the samples to be mixed 120 in the 10 sample containers 110 can be mixed by using the same mixing mode, such as Figure 7As shown, the sample feeding unit 14 sequentially feeds a plurality of sample containers 110 in the feeding direction D, and when the control unit 12 acquires the bottom position of the containing cavity 101 of the first sample container 110, a matching mixing mode is selected, and then the samples 120 to be mixed in the second to tenth sample containers 110 can be mixed by the mixing mode. In actual application, in order to avoid the influence of the samples to be mixed on the acquisition of the bottom position of the containing cavity 101 of the first sample container 110, the first sample container 110 can be an empty sample container, that is, there is no sample 120 to be mixed, and only the second to tenth sample containers 110 have samples 120 to be mixed.

[0040] It can be understood that in actual application, in addition to the preset number, the operator can also check the actual number on the display interface of the control unit 12 according to the actual situation, for example, a type of sample container 110 is replaced by another type of sample container 110, at this time, the operator can check according to the actual number of the replaced sample container 110.

[0041] Further, the mixing device 10 in the embodiment further includes a transfer unit 15, which is used to transfer the sample container 110 on the sample feeding unit 14 to the mixing unit 11, that is, to the mixing seat 112 in the embodiment, so that the mixing unit 11 mixes the samples 120 to be mixed in the sample container 110.

[0042] The embodiment of the application also provides a sample analyzer, which includes the mixing device 10 in the above embodiment and a detection device, and the detection device is used to detect the samples 120 to be mixed after mixing.

[0043] It can be understood that the specific type of the sample analyzer and the specific detection method of the detection device are not limited in the embodiment.

[0044] The application has the beneficial effect that, different from the prior art, the mixing device provided by the application comprises a mixing unit for carrying a sample container, the sample container is formed with a containing cavity, and the mixing unit is used for mixing the sample to be mixed in the containing cavity; a control unit is electrically connected with the mixing unit, the control unit is used for acquiring the bottom position of the containing cavity and selecting a mixing mode matched with the bottom position of the containing cavity, so that the mixing unit mixes the sample to be mixed in the containing cavity according to the matched mixing mode. Through this arrangement, for different sample containers, one mixing unit can mix the sample to be mixed through the mixing mode matched with the bottom position of the containing cavity, without the need to additionally increase other structures, and the situation that the sample mixing is insufficient and the sample has a more serious "wall-hanging phenomenon", resulting in a large deviation of the detection result, can be avoided, while the sample to be mixed and the anticoagulant can be reduced, so that the detection result is more accurate.

[0045] The above only describes some embodiments of the application, and does not limit the protection scope of the application, and any equivalent device or equivalent process transformation using the content of the specification and drawings, or direct or indirect application in other related technical fields, are also included in the patent protection scope of the application.

Claims

1. A mixing device, characterized by The mixing device comprises: a mixing unit for carrying a sample container, the sample container being formed with a containing cavity, the mixing unit being used for mixing operation on a sample to be mixed in the containing cavity; a control unit electrically connected with the mixing unit, the control unit being used for acquiring a bottom position of the containing cavity and selecting a mixing mode matched with the bottom position of the containing cavity, so that the mixing unit performs mixing operation on the sample to be mixed in the containing cavity according to the matched mixing mode.

2. The blending device of claim 1, wherein, The mixing device further comprises a sampling unit, the sampling unit comprising a sampling driving mechanism and a sampling needle, the sampling driving mechanism being connected with the sampling needle to drive the sampling needle to be inserted into the containing cavity, and the control unit being electrically connected with the sampling driving mechanism to determine the bottom position of the containing cavity according to a movement distance of the sampling needle.

3. The blending device of claim 2, wherein, The mixing unit comprises a centrifugal motor and a mixing seat, the mixing seat being used for carrying the sample container and being connected with an output shaft of the centrifugal motor, so that the centrifugal motor drives the sample container to perform centrifugal mixing on the sample to be mixed.

4. The blending device of claim 3, wherein, The control unit is used for selecting a mixing mode matched with the movement distance of the sampling needle.

5. The blending device of claim 3, wherein, The control unit is further used for determining a depth of the containing cavity according to the bottom position of the containing cavity and selecting a mixing mode matched with the depth of the containing cavity.

6. The blending device of claim 3, wherein, The control unit is further used for acquiring a rotation center position of the mixing seat and calculating a spacing distance between the rotation center position and the bottom position of the containing cavity, so that the control unit selects a mixing mode matched with the spacing distance.

7. The blending device of claim 1, wherein, The mixing device further comprises a sample feeding unit, the sample feeding unit being used for sequentially feeding a plurality of sample containers, the control unit being used for acquiring a bottom position of a containing cavity of a first sample container and selecting a mixing mode matched with the bottom position of the containing cavity of the first sample container, so that the mixing unit performs mixing operation on samples to be mixed in a preset number of sample containers according to the matched mixing mode.

8. The blending device of claim 7, wherein, The mixing device further comprises a transfer unit, the transfer unit being used for transferring the sample containers on the sample feeding unit to the mixing unit.

9. The blending device of claim 1, wherein, The mixing mode comprises a mixing strength and a mixing time.

10. A sample analyzer characterized by, The sample analyzer comprises a detection device and the mixing device according to any one of claims 1-9, the detection device being used for detecting the sample to be mixed after mixing.

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