High-stability selenium disulfide slurry composition and preparation method thereof
By using microencapsulation technology and specific ingredient combinations, the problem of insufficient stability of selenium disulfide has been solved, resulting in a selenium disulfide slurry composition with high stability and long-lasting antibacterial effect, suitable for personal care products and the pharmaceutical field.
Patent Information
- Application Number
- CN202511756700.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-27
- Publication Date
- 2026-02-06
AI Technical Summary
In existing technologies, selenium disulfide has insufficient stability, which leads to problems such as high loss rate of active ingredients, agglomeration and decomposition, poor compatibility, and safety risks in its production, processing, storage, transportation, and end-product applications, making it difficult to achieve a balance between stability and efficacy.
Using microencapsulation technology, selenium disulfide is encapsulated in microcapsule wall materials formed by cross-linking corn starch, phosphated corn starch, and chitosan. Combined with glycerol, disodium lauryl sulfosuccinate, and other ingredients, a highly stable selenium disulfide slurry composition is formed, which enhances its dispersibility and stability in solvents. At the same time, tocopherol compounds are added to improve antioxidant properties and reduce the risk of skin irritation.
It achieves high stability of selenium disulfide in polar solvents, avoids aggregation and stratification, maintains long-term antibacterial effect, improves product safety and user experience, and reduces the risk of skin irritation.
Smart Images
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Abstract
Description
Technical Field
[0001] This invention relates to the field of washing and care products technology, specifically to a highly stable selenium disulfide slurry composition and its preparation method. Background Technology
[0002] Selenium disulfide, an active ingredient with highly effective antibacterial, anti-inflammatory, and keratin metabolism-regulating properties, occupies an important position in various fields such as daily chemicals, pharmaceuticals, and skin care due to its strong inhibitory effect on fungi and excellent anti-inflammatory activity. It has become one of the core raw materials for solving problems such as scalp itching, increased dandruff, and tinea caused by fungi. In the daily chemical field, it is widely used in anti-dandruff shampoos and antifungal skin care products; in the pharmaceutical field, it is a key ingredient in topical antifungal preparations used to improve skin conditions such as seborrheic dermatitis and tinea versicolor; it also has potential applications in industrial antifungal applications. As the demand for high-efficiency and highly reliable active ingredients continues to upgrade in related industries, the application scenarios of selenium disulfide are constantly expanding. However, due to its own physicochemical properties, the problem of insufficient stability is becoming increasingly prominent throughout the entire chain of production, processing, storage, transportation, and end-product application, seriously restricting the full realization of its efficacy and the further expansion of its application scope, becoming a technical bottleneck that the industry urgently needs to overcome.
[0003] Current industry improvements in the stabilization of selenium disulfide mainly focus on component adaptation, dosage form optimization, and the application of auxiliary technologies: First, selenium disulfide powder or crystals are directly added to various product systems, achieving basic efficacy through simple physical mixing. This method is simple to operate, low in cost, and suitable for low-end products with low stability requirements. Second, antioxidants and chelating agents are introduced into the formulation to slow down the decomposition rate of selenium disulfide and extend the product's shelf life by inhibiting oxidation reactions and isolating catalytically decomposing metal ions. Third, simple coating or dispersion techniques are used to mix selenium disulfide with natural polymers such as gum arabic and gelatin to improve its dispersibility in the system and reduce agglomeration. Fourth, formulation system parameters are optimized for different application scenarios, such as adjusting the ratio of aqueous and oil phases, controlling pH value, or using specific solvents to reduce the interaction between selenium disulfide and other components, reducing the impact of the external environment on its stability. Fifth, some solutions reduce the concentration of selenium disulfide in the product to reduce the risk of agglomeration and decomposition due to excessive concentration, but this method directly sacrifices the product's core efficacy.
[0004] However, existing technologies still have significant and insurmountable drawbacks in addressing the stability issues of selenium disulfide: First, its chemical stability is extremely poor. Selenium disulfide is highly sensitive to external environmental factors such as light, temperature, and oxygen. Under normal storage conditions, the monthly loss rate of active ingredients is high. During product processing (such as high-temperature emulsification and stirring), it is prone to oxidative decomposition at temperatures exceeding 40°C, leading not only to a significant decrease in activity but also the generation of irritating byproducts, affecting the safety of the final product. Second, its physical stability is insufficient. Selenium disulfide itself has extremely poor water solubility, easily agglomerating into large particles with diameters of tens of micrometers in aqueous or oil-based product systems. This not only reduces the contact area between the active ingredient and the target, significantly weakening the efficacy utilization rate, but may also lead to problems such as product layering, precipitation, and uneven coloring, seriously affecting the product's appearance and user experience. Third, its formulation compatibility is poor. Selenium disulfide is incompatible with cations... Many commonly used formulation ingredients, such as ionic surfactants, some nitrogen-containing preservatives, and phenolic components, have clear incompatibilities, easily leading to chemical reactions and system instability. Furthermore, their active ingredients continuously diminish over time during long-term storage, making it difficult to guarantee the consistency of efficacy of the final product within its shelf life. Fourth, existing stabilization technologies have limited effectiveness and side effects. Traditional stabilizers require a certain proportion to be effective; excessive addition may cause skin irritation, allergies, and other problems. Simple encapsulation technologies have loose, easily damaged capsule structures, failing to effectively isolate selenium disulfide from external environmental influences and thus failing to fundamentally solve the stability problem. Fifth, there is an inherent contradiction between stability and efficacy. Improving stability in existing technologies often requires sacrificing the effective concentration or activity release efficiency of selenium disulfide, resulting in products that either meet stability standards but lack efficacy, or have significant efficacy but extremely poor stability, making it difficult to achieve a balance between the two.
[0005] In conclusion, a new technical solution is urgently needed to address the problems existing in the current technology. Summary of the Invention
[0006] To address the shortcomings and deficiencies of the existing technology, this invention provides a highly stable selenium disulfide slurry composition and its preparation method. This invention exhibits excellent stability, is less prone to discoloration and delamination, and provides long-lasting antibacterial effects while being gentler on the skin.
[0007] One object of the present invention is to provide a highly stable selenium disulfide slurry composition, said highly stable selenium disulfide slurry composition comprising the following components in mass fractions: Selenium disulfide microcapsules 1-30% 30-50% glycerin Disodium lauryl sulfosuccinate 1-10% Hydroxyethyl diphosphate 1-5% Cocamidopropyl betaine 1-5% Tocopherols 0.1-5% Hydrogenated castor oil 0.1-5% Cocamide methyl MEA 0.1-5% Phenoxyethanol 0.1-0.5% Water balance; The wall material of the selenium disulfide microcapsules is obtained by blending corn starch, phosphorylated corn starch, and chitosan, and then reacting them with citric acid.
[0008] Furthermore, the preparation method of the phosphorylated corn starch is as follows: Corn starch, water, and catalyst are mixed together, and the pH value is adjusted to 10-12. Potassium tripolyphosphate is added, and the mixture is heated to react. After the reaction is completed, the pH value is adjusted again to 6-8 to obtain phosphorylated corn starch.
[0009] Furthermore, the mass ratio of corn starch to potassium tripolyphosphate is (5-20):1.
[0010] Furthermore, the heating temperature is 40-50℃.
[0011] Furthermore, the tocopherol compounds are selected from one or more of natural tocopherol, tocopherol acetate, and tocotrienol.
[0012] Another object of the present invention is to provide a method for preparing a highly stable selenium disulfide slurry composition, the method comprising the following steps: S1. Chitosan, corn starch, and phosphorylated corn starch are mixed, heated and stirred until evenly dispersed, then glycerol is added and the mixture is stirred to obtain an intermediate product. S2. Add citric acid to the intermediate product, heat and stir to react, and obtain the wall material solution; S3. Selenium disulfide is mixed with the wall material solution, stirred evenly, solvent is removed, and then cryogenically pulverized to obtain selenium disulfide microcapsules. S4. The selenium disulfide microcapsules are mixed with the remaining components and then mixed by high-pressure jet milling to obtain a highly stable selenium disulfide slurry composition.
[0013] Furthermore, the mass ratio of chitosan, corn starch, phosphorylated corn starch, and selenium disulfide is (2-6):(1-3):(2-5):(4-10).
[0014] Furthermore, in step S1, the heating temperature is 50-70℃.
[0015] Furthermore, in step S2, the heating temperature is 50-70℃.
[0016] Furthermore, in step S4, the temperature of the high-pressure jet mill is 85-90℃, the flow rate is 300-400 m / s, and the pressure is 80-100 MPa.
[0017] The present invention has the following beneficial effects: This invention provides a highly stable selenium disulfide slurry composition and its preparation method. The components of the highly stable selenium disulfide slurry composition include: selenium disulfide microcapsules, glycerol, disodium lauryl sulfosuccinate, hydroxyethyl diphosphate, cocamidopropyl betaine, tocopheryl acetate, hydrogenated castor oil, cocamidomethyl MEA, phenoxyethanol, and water. The wall material of the selenium disulfide microcapsules is obtained by blending corn starch, phosphorylated corn starch, and chitosan, followed by reaction with citric acid. This invention presents a self-made microcapsule wall material. Citric acid is used to crosslink corn starch, phosphated corn starch, and chitosan, forming a three-dimensional network structure that encapsulates and fixes selenium disulfide. The numerous amino groups in chitosan further enhance the adsorption stability of selenium disulfide through electrostatic attraction, preventing premature hydrolysis and oxidation of selenium disulfide in the system. Simultaneously, the modified phosphate groups are highly polar groups with good compatibility with polar solvents, making the microcapsule particles easily dispersed and preventing aggregation and stratification in the solvent. This significantly enhances the stability of the system while strengthening the internal binding force of the wall material, improving the stability of the microcapsule structure. Furthermore, the components of the microcapsule wall material are all natural polysaccharides, possessing excellent biocompatibility with the modified phosphate groups, making the invention more skin-friendly. Moreover, the microcapsule encapsulation slows down the release rate of selenium disulfide, preventing skin irritation from excessively high selenium disulfide concentrations.
[0018] Glycerin and water, acting as solvents, not only hydrate and moisturize but also promote the penetration and absorption of other active ingredients. Disodium lauryl sulfosuccinate and cocamidopropyl betaine form a gentle cleansing system; the former has moderate cleansing power and low irritation, while the latter, as an amphoteric surfactant, neutralizes potential irritation from other ingredients, protects the skin's lipid barrier, and enhances skin softness. Combined with cocamidopropyl MEA, it further optimizes the skin feel, reducing astringency and discomfort during cleansing. Hydrogenated castor oil synergistically promotes water retention. Tocopherols possess excellent antioxidant properties, scavenging free radicals and reducing environmental damage to the skin. Hydroxyethylphosphonic acid stabilizes the formula by chelating metal ions, preventing them from interfering with skin condition. Low concentrations of phenoxyethanol gently inhibit bacteria and prevent product deterioration while minimizing the risk of skin sensitization. The overall synergistic effect of the ingredients ensures the effectiveness of selenium disulfide while providing gentle cleansing and barrier protection for the skin. Detailed Implementation
[0019] To more clearly illustrate the technical solution of the present invention, the following embodiments are provided. Unless otherwise stated, the raw materials, reactions, and post-processing methods appearing in the embodiments are all commercially available raw materials and technical methods well known to those skilled in the art.
[0020] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.
[0021] It should be understood that, except in any operational instance or otherwise indicated, the amounts or all figures representing ingredients used, for example, in the specification and claims, should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximate values varying according to the desired performance to be obtained according to the invention.
[0022] In the examples and comparative examples, the following raw materials will be used: Selenium disulfide, brand name SeleneGuard 100, was purchased from Guangzhou Xianghai Technology Co., Ltd.
[0023] Corn starch, brand name SX016, was purchased from Suzhou Haichuang Chemical.
[0024] Cocamidopropyl betaine, brand name YESER® 213, was purchased from Guangdong Yeshi Industrial Co., Ltd.
[0025] Hydrogenated castor oil, brand name Kolliwax® HCO, purchased from BASF.
[0026] Cocamide methyl MEA, brand name Yeser® CMMEA, was purchased from Guangdong Yeshi Industrial Co., Ltd.
[0027] Phosphate-esterified corn starch, homemade, preparation method includes the following steps: Add 1 part corn starch to 4 parts water, stir at 150 rpm, add 0.03 parts of 0.05 M potassium sulfate aqueous solution, adjust the pH to 11 with 0.1 M sodium hydroxide aqueous solution, add 0.1 parts potassium tripolyphosphate, heat to 45℃ and react for 3 h. After the reaction is completed, adjust the pH to 7.0 again with 1 M hydrochloric acid aqueous solution, filter and dry to obtain phosphorylated corn starch.
[0028] Unless otherwise specified, the water used in the embodiments of this invention refers to deionized water.
[0029] In the embodiments of this invention, "parts" refers to parts by mass.
[0030] Example 1 A highly stable selenium disulfide slurry composition, the highly stable selenium disulfide slurry composition comprising the following components by mass fraction: 20% selenium disulfide microcapsules 40% glycerin Disodium lauryl sulfosuccinate 6% 3% Hydroxyethyl diphosphate Cocamidopropyl betaine 3% Tocopheryl acetate 1% 1% hydrogenated castor oil Cocamide methyl MEA 1% Phenoxyethanol 0.3% Water balance; The preparation method of the highly stable selenium disulfide slurry composition includes the following steps: S1. Disperse 1.5 parts of corn starch and 3.5 parts of phosphorylated corn starch in 95 parts of water and gelatinize at 95°C for 2 hours to prepare a starch solution. Disperse 4 parts of chitosan in 196 parts of 1% (v / v) acetic acid aqueous solution and stir at 60°C for 2 hours to prepare a chitosan solution. Mix 100 parts of starch solution with 200 parts of chitosan solution, heat to 60°C, stir for 30 minutes, and after uniform dispersion, add 3 parts of glycerol and stir for 10 minutes to obtain an intermediate product. S2. Add 6 parts of citric acid, heat to 60℃ and stir for 30 min to obtain the wall material solution; S3. Disperse 1 part of selenium disulfide in 100 parts of 30 wt% ethanol aqueous solution to obtain a selenium disulfide suspension. Mix the selenium disulfide suspension with the wall material solution at a mass ratio of 3:1. After stirring evenly, dry in a vacuum drying oven at 40℃. Freeze-crush at -10℃ to obtain selenium disulfide microcapsules with a particle size of 10-20 μm. S4. According to the above mass fraction, the selenium disulfide microcapsules are mixed with the remaining components and mixed by high-pressure jet milling at 85°C, 400 m / s flow rate and 100 MPa pressure to obtain a highly stable selenium disulfide slurry composition.
[0031] Example 2 A highly stable selenium disulfide slurry composition, the highly stable selenium disulfide slurry composition comprising the following components by mass fraction: 15% selenium disulfide microcapsules 40% glycerin Disodium lauryl sulfosuccinate 6% 3% Hydroxyethyl diphosphate Cocamidopropyl betaine 4% Tocopheryl acetate 2% 1% hydrogenated castor oil Cocamide methyl MEA 1% Phenoxyethanol 0.3% Water balance; The preparation method of the highly stable selenium disulfide slurry composition includes the following steps: S1. Disperse 1.5 parts of corn starch and 3.5 parts of phosphorylated corn starch in 95 parts of water and gelatinize at 95°C for 2 hours to prepare a starch solution. Disperse 4 parts of chitosan in 196 parts of 1% (v / v) acetic acid aqueous solution and stir at 60°C for 2 hours to prepare a chitosan solution. Mix 100 parts of starch solution with 200 parts of chitosan solution, heat to 60°C, stir for 30 minutes, and after uniform dispersion, add 3 parts of glycerol and stir for 10 minutes to obtain an intermediate product. S2. Add 6 parts of citric acid, heat to 60℃ and stir for 30 min to obtain the wall material solution; S3. Disperse 1 part of selenium disulfide in 100 parts of 30 wt% ethanol aqueous solution to obtain a selenium disulfide suspension. Mix the selenium disulfide suspension with the wall material solution at a mass ratio of 3:1. After stirring evenly, dry in a vacuum drying oven at 40℃. Freeze-crush at -10℃ to obtain selenium disulfide microcapsules with a particle size of 10-20 μm. S4. According to the above mass fraction, the selenium disulfide microcapsules are mixed with the remaining components and mixed by high-pressure jet milling at 85°C, 400 m / s flow rate and 100 MPa pressure to obtain a highly stable selenium disulfide slurry composition.
[0032] Example 3 A highly stable selenium disulfide slurry composition, the highly stable selenium disulfide slurry composition comprising the following components by mass fraction: Selenium disulfide microcapsules 25% 36% glycerin Disodium lauryl sulfosuccinate 5% 3% Hydroxyethyl diphosphate Cocamidopropyl betaine 3% Tocopheryl acetate 1% 1% hydrogenated castor oil Cocamide methyl MEA 1% Phenoxyethanol 0.3% Water balance; The preparation method of the highly stable selenium disulfide slurry composition includes the following steps: S1. Disperse 1 part corn starch and 4 parts phosphorylated corn starch in 95 parts water and gelatinize at 95°C for 2 h to prepare a starch solution. Disperse 4 parts chitosan in 196 parts of 1% acetic acid aqueous solution and stir at 60°C for 2 h to prepare a chitosan solution. Mix 100 parts starch solution and 200 parts chitosan solution, heat to 60°C, stir for 30 min, and after uniform dispersion, add 3 parts glycerol and stir for 10 min to obtain an intermediate product. S2. Add 6 parts of citric acid, heat to 60℃ and stir for 30 min to obtain the wall material solution; S3. Disperse 1 part of selenium disulfide in 100 parts of 30 wt% ethanol aqueous solution to obtain a selenium disulfide suspension. Mix the selenium disulfide suspension with the wall material solution at a mass ratio of 3:1. After stirring evenly, dry in a vacuum drying oven at 40℃. Freeze-crush at -10℃ to obtain selenium disulfide microcapsules with a particle size of 10-20 μm. S4. According to the above mass fraction, the selenium disulfide microcapsules are mixed with the remaining components and mixed by high-pressure jet milling at 85°C, 400 m / s flow rate and 100 MPa pressure to obtain a highly stable selenium disulfide slurry composition.
[0033] Comparative Example 1 A highly stable selenium disulfide slurry composition. The difference between this comparative example and Example 1 is that the phosphorylated corn starch in step S1 is replaced with an equal mass of corn starch, while the other steps and amounts are the same as in Example 1.
[0034] Comparative Example 2 A highly stable selenium disulfide slurry composition is described. The difference between this comparative example and Example 1 is that step S2 is deleted, and the wall material solution is replaced with an intermediate product. The other steps and dosages are the same as in Example 1.
[0035] Test Example 1 The stability of the highly stable selenium disulfide slurry compositions prepared in Examples 1-3 and Comparative Examples 1-2 was tested.
[0036] Test method: Take 30 mL of each of the highly stable selenium disulfide slurry compositions prepared in Examples 1-3 and Comparative Examples 1-2, encapsulate them in transparent cosmetic bottles, and place them in environments of -15±2℃, 4±2℃, 25±2℃, and 45±2℃ respectively. After 90 days, visually observe them. If there is no obvious discoloration, layering, or precipitation, they are considered qualified.
[0037] The test results are shown in Table 1.
[0038] Table 1 Stability Test Results As shown in Table 1, the embodiments of the present invention exhibit good stability under both high and low temperature environments. However, the microcapsule wall material of Comparative Example 1 lacks phosphate ester groups, resulting in poor compatibility with polar solvents. Agglomeration and delamination occur under high or low temperature environments, affecting its use. The microcapsule wall material of Comparative Example 2 is not cross-linked, resulting in poor stability. It easily swells in polar solvents, prematurely releasing the internal selenium disulfide particles and losing its protective effect on selenium disulfide. Since selenium disulfide has poor dispersibility in water, it easily agglomerates and delaminates, and is also prone to oxidation and hydrolysis.
[0039] Test Example 2 The highly stable selenium disulfide slurry compositions prepared in Examples 1-3 and Comparative Examples 1-2 were subjected to in vitro antibacterial tests.
[0040] Test method: Take 10 mL of each of the highly stable selenium disulfide slurry compositions prepared in Examples 1-3 and Comparative Examples 1-2, add them to 100 mL of water at 40°C, and stir until homogeneous to obtain a diluted solution. A bacterial suspension of 10⁵ CFU was prepared from Malassezia furfur. It was then evenly spread onto agar plates and placed in a sterile operating table to air dry. Use sterile forceps to pick up three sterile filter paper discs, soak them in Examples 1-3 and Comparative Examples 1-2 respectively, drain off excess water, place them on culture medium plates, transfer them to a 30°C constant temperature incubator for 7 days, observe the results, and record the measurement of the inhibition zone. Results were determined according to the National Committee for Standardization of Clinical Trials (NCCLS) standards: inhibition zone diameter <8 mm was considered insensitive, 8-13 mm was considered lowly sensitive, 13-19 mm was considered moderately sensitive, and >19 mm was considered highly sensitive.
[0041] The test results are shown in Table 2.
[0042] Table 2 Results of in vitro antibacterial test As shown in Table 2, Examples 1-3 of the present invention all have excellent inhibitory effects on Malassezia furfur. The poor effect of Comparative Example 1 may be because the microcapsule wall material lacks phosphate ester groups, resulting in excessively high stability of the wall material, which cannot efficiently release selenium disulfide. The microcapsule wall material of Comparative Example 2 is not cross-linked, has poor stability, and cannot protect and fix selenium disulfide, which easily leads to excessively high concentration in the early stage and insufficient concentration in the later stage.
[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.
[0044] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.
Claims
1. A highly stable selenium disulfide slurry composition, characterized in that, The highly stable selenium disulfide slurry composition comprises the following components by mass fraction: Selenium disulfide microcapsules 1-30% 30-50% glycerin Disodium lauryl sulfosuccinate 1-10% Hydroxyethyl diphosphate 1-5% Cocamidopropyl betaine 1-5% Tocopherols 0.1-5% Hydrogenated castor oil 0.1-5% Cocamide methyl MEA 0.1-5% Phenoxyethanol 0.1-0.5% Water balance; The wall material of the selenium disulfide microcapsules is obtained by blending corn starch, phosphorylated corn starch, and chitosan, and then reacting them with citric acid.
2. The highly stable selenium disulfide slurry composition according to claim 1, characterized in that, The method for preparing the phosphorylated corn starch is as follows: Corn starch, water, and catalyst are mixed together, and the pH value is adjusted to 10-12. Potassium tripolyphosphate is added, and the mixture is heated to react. After the reaction is completed, the pH value is adjusted again to 6-8 to obtain phosphorylated corn starch.
3. The highly stable selenium disulfide slurry composition according to claim 2, characterized in that, The mass ratio of corn starch to potassium tripolyphosphate is (5-20):
1.
4. The highly stable selenium disulfide slurry composition according to claim 2, characterized in that, The heating temperature is 40-50℃.
5. The highly stable selenium disulfide slurry composition according to claim 1, characterized in that, The tocopherol compounds are selected from one or more of natural tocopherol, tocopherol acetate, and tocotrienol.
6. A method for preparing the highly stable selenium disulfide slurry composition according to any one of claims 1-5, characterized in that, The preparation method of the highly stable selenium disulfide slurry composition includes the following steps: S1. Chitosan, corn starch, and phosphorylated corn starch are mixed, heated and stirred until evenly dispersed, then glycerol is added and the mixture is stirred to obtain an intermediate product. S2. Add citric acid to the intermediate product, heat and stir to react, and obtain the wall material solution; S3. Selenium disulfide is mixed with the wall material solution, stirred evenly, solvent is removed, and then cryogenically pulverized to obtain selenium disulfide microcapsules. S4. The selenium disulfide microcapsules are mixed with the remaining components and then mixed by high-pressure jet milling to obtain a highly stable selenium disulfide slurry composition.
7. The method for preparing the highly stable selenium disulfide slurry composition according to claim 6, characterized in that, The mass ratio of chitosan, corn starch, phosphorylated corn starch, and selenium disulfide is (2-6):(1-3):(2-5):(4-10).
8. The method for preparing the highly stable selenium disulfide slurry composition according to claim 6, characterized in that, In step S1, the heating temperature is 50-70℃.
9. The method for preparing the highly stable selenium disulfide slurry composition according to claim 6, characterized in that, In step S2, the heating temperature is 50-70℃.
10. The method for preparing the highly stable selenium disulfide slurry composition according to claim 6, characterized in that, In step S4, the temperature of the high-pressure jet mill is 85-90℃, the flow rate is 300-400 m / s, and the pressure is 80-100 MPa.