Modular fluid filter cartridge assembly

Abstract

The invention relates to a cartridge assembly. The inlet cartridge plate defines an inlet cartridge inlet flow path and an inlet cartridge outlet flow path. The outlet cassette plate is configured in a stacked arrangement with the inlet cassette plate. The outlet cassette plate defines an outlet cassette inlet flow path configured to laterally align with the inlet cassette inlet flow path, and an outlet cassette outlet flow path configured to laterally align with the inlet cassette outlet flow path. The inlet plug is configured to be inserted into the outlet cartridge inlet flow path. The outlet plug is configured to be inserted into the inlet cartridge outlet flow path. The inlet plug and the outlet plug are configured to be removable and reinsertable. And the separation layer is arranged between the inlet box plate and the outlet box plate.

Description

Related applications

[0001] This application claims priority to U.S. Provisional Patent Application No. 63 / 455,870, filed March 30, 2023, entitled "Modular Fluid Filtration Cassette Assembly," which is incorporated herein by reference in its entirety under 35 USC §119(e). Technical Field

[0002] This disclosure generally relates to a filter cartridge assembly. More specifically, this disclosure relates to a modular fluid filter cartridge assembly. Background Technology

[0003] Fluid filter cartridges can be used in applications such as membrane chromatography, tangential flow filtration (TFF), and various microfiltration applications. These applications often require large filtration volumes or rapid filtration. Therefore, more than one cartridge may be needed simultaneously. For example, various parallel and serial cartridge assemblies can be used. Inappropriate number of cartridges, improper alignment of cartridges within the assembly, inappropriate pressure levels within the cartridge assembly, and other factors can interfere with the operation of components and equipment.

[0004] It may also be desirable to promote a uniform fluid flow that crosses laterally across the first side of the separator layer disposed within the cartridge, axially through the separator layer, and laterally across the opposite side of the separator layer once the fluid has passed through it. Such uniform flow improves fluid filtration. Uniform flow can also result in more consistent and easier-to-control pressure within each cartridge and within the cartridge assembly. Therefore, the fluid filter cartridge may have an inlet channel that carries the fluid to the separator layer in a manner that promotes uniform flow.

[0005] It may also be desirable to remove gas from the cartridge assembly to promote consistent pressure and fluid flow during filtration. Summary of the Invention

[0006] The technology disclosed herein relates to a cartridge assembly with a modular configuration, allowing the assembly to be adapted to various operating conditions and environments. The filter assembly can incorporate one or more cartridges and can be modified relatively easily to incorporate additional or fewer cartridges. In a filter assembly with multiple cartridges, such cartridges are arranged in parallel for fluid filtration. The fluid inlet of a cartridge is fluidly coupled to each cartridge in the assembly for parallel filtration through each cartridge. The fluid outlet of a cartridge is fluidly coupled to each cartridge in the assembly for parallel filtration through each cartridge. Each cartridge is configured to receive a removable plug to selectively block a specific flow path defined by a particular cartridge based on the cartridge's location within the assembly. This configuration further allows for modularity of the cartridge assembly.

[0007] In one or more embodiments, the cartridge assembly includes an inlet cartridge plate. The inlet cartridge plate defines an inlet cartridge inlet flow path and an inlet cartridge outlet flow path. The inlet cartridge inlet flow path and the inlet cartridge outlet flow path extend axially through the inlet cartridge plate. The cartridge assembly further includes an outlet cartridge plate. The outlet cartridge plate is configured for a stacked arrangement with the inlet cartridge plate. The outlet cartridge plate defines an outlet cartridge inlet flow path and an outlet cartridge outlet flow path. The outlet cartridge inlet flow path and the outlet cartridge outlet flow path extend axially through the outlet cartridge plate. The inlet cartridge inlet flow path is configured to be laterally aligned with the outlet cartridge inlet flow path. The inlet cartridge outlet flow path is configured to be laterally aligned with the outlet cartridge outlet flow path. The cartridge assembly further includes an inlet plug. The inlet plug is configured to be inserted into the outlet cartridge inlet flow path to seal the outlet cartridge inlet flow path. The inlet plug is configured to be removable and re-insertable into the outlet cartridge inlet flow path. The cartridge assembly further includes an outlet plug. The outlet plug is configured to be inserted into the inlet cartridge outlet flow path to seal the inlet cartridge outlet flow path. The outlet plug is configured to be removable and re-insertable into the inlet cartridge outlet flow path. The cartridge assembly further includes a separation layer. The separation layer is disposed between the inlet cartridge plate and the outlet cartridge plate. The inlet cartridge inlet flow path is configured to be in fluid communication with the outlet cartridge outlet flow path through the separation layer to form an assembly flow path.

[0008] In some embodiments, the inlet cartridge plate, the outlet cartridge plate, the inlet plug, the outlet plug, and the separation layer define a single cartridge. Additionally or alternatively, the inlet cartridge plate, the outlet cartridge plate, the inlet plug, the outlet plug, and the separation layer define more than one cartridge.

[0009] Additionally or alternatively, the cartridge assembly further includes an inlet channel extending along an effective inlet surface area of the separation layer in fluid communication with the inlet cartridge inlet flow path, and further includes an outlet channel extending along an effective outlet surface area of the separation layer toward the outlet cartridge outlet flow path. Additionally or alternatively, the cartridge assembly further includes an inlet flow path extension defined by the inlet cartridge plate configured to fluidly couple the inlet cartridge inlet flow path and the inlet channel, and further includes an outlet flow path extension defined by the outlet cartridge plate configured to fluidly couple the outlet cartridge outlet flow path and the outlet channel. Additionally or alternatively, the inlet flow path extension includes an inlet extension first portion extending laterally from the inlet cartridge inlet flow path toward the inlet channel, and an inlet extension second portion extending laterally along a width of the effective inlet surface area. Additionally or alternatively, the outlet flow path extension includes an outlet extension first portion extending laterally from the outlet cartridge outlet flow path toward the outlet channel, and an outlet extension second portion extending laterally along a width of the effective outlet surface area.

[0010] Additionally or alternatively, the cartridge assembly further includes a separation layer seal mounted between the inlet cartridge plate and the outlet cartridge plate. The separation layer seal is in contact with the inlet cartridge plate and the outlet cartridge plate. The separation layer seal is configured to fluidically seal a perimeter region of the separation layer, a perimeter region of the inlet channel, and a perimeter region of the outlet channel. Additionally or alternatively, the separation layer seal has an overmolded gasket.

[0011] Additionally or alternatively, the inlet cartridge plate defines a first port in selective fluid communication with the inlet cartridge inlet flow path, and the first port extends laterally through an axial surface of the inlet cartridge plate, and the outlet cartridge plate defines a second port in selective fluid communication with the outlet cartridge outlet flow path, and the second port extends laterally through an axial surface of the outlet cartridge plate, and the cartridge assembly has a first port plug configured to seal the first port, the first port plug being removable and reinsertable into the first port, and the cartridge assembly has a second port plug configured to seal the second port, the second port plug being removable and reinsertable into the second port.

[0012] Additionally or alternatively, the separation layer has a membrane stack having a plurality of membrane layers, and the plurality of membrane layers includes at least 10 membrane layers. Additionally or alternatively, the separation layer has an effective inlet surface area defined by an effective length and an effective width, and the effective length is at least 2.5 times the effective width.

[0013] Additionally or alternatively, the cartridge assembly further includes an outlet channel spacer positioned in the outlet channel, wherein the outlet channel spacer is configured to contain a fluid flow. Additionally or alternatively, the cartridge assembly further includes an inlet channel spacer positioned in the inlet channel, wherein the inlet channel spacer is configured to contain a fluid flow. Additionally or alternatively, at least one of the inlet channel spacer and the outlet channel spacer has a lateral ridge extending across the separation layer.

[0014] Additionally or alternatively, the outlet cartridge plate includes an alignment feature, and the inlet cartridge plate includes a mating alignment feature, and the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet cartridge plate and the inlet cartridge plate.

[0015] Additionally or alternatively, the cartridge assembly further includes a first end plate operatively coupled to the inlet cartridge plate, and a second end plate operatively coupled to the outlet cartridge plate. The first end plate includes a first inlet port configured to extend into the inlet cartridge inlet flow path, and the second end plate includes a second outlet port configured for fluid communication with the outlet cartridge outlet flow path.

[0016] Additionally or alternatively, the cartridge assembly further includes a fastener configured to operatively couple the inlet cartridge plate and the outlet cartridge plate. Additionally or alternatively, the cartridge assembly has a fastener configured to operatively couple the first end plate, the inlet cartridge plate, the outlet cartridge plate, and the second end plate. Additionally or alternatively, the fastener includes a bolt, and the inlet cartridge plate defines a first axial through-hole and the outlet cartridge plate defines a second axial through-hole. The first axial through-hole and the second axial through-hole are configured to be laterally aligned to accommodate the bolt. Additionally or alternatively, the cartridge assembly has a first nut configured to accommodate one end of the bolt and a second nut configured to accommodate an opposite end of the bolt, and the first nut and the second nut are configured to exert a compressive force on the cartridge assembly. Additionally or alternatively, the first end plate defines a third axial through-hole and the second end plate defines a fourth axial through-hole, and each of the first axial through-hole, the second axial through-hole, the third axial through-hole, and the fourth axial through-hole are configured to be laterally aligned to accommodate the bolt.

[0017] Additionally or alternatively, the cartridge assembly further includes an attachment seal between the inlet cartridge plate and the outlet cartridge plate. The attachment seal extends laterally around and outside of a periphery of the separation layer.

[0018] The above summary of the invention is not intended to describe each embodiment or every implementation of the invention. Rather, a more complete understanding of illustrative embodiments is available by reference to the following detailed description and claims in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 is a first perspective view of an example fluid filter cartridge assembly consistent with various embodiments.

[0020] Figure 2 is a second perspective view consistent with examples of Figure 1

[0021] Figure 3A is a third perspective cross-sectional view consistent with examples of Figures 1-2

[0022] Figure 3B is a partial close-up view of Figure 3A

[0023] Figure 3C is a second partial close-up view of Figure 3A

[0024] Figure 4 is a partial close-up view for Figure 3A

[0025] Figure 5 is an exploded perspective view of an example cartridge consistent with some examples.

[0026] Figure 6 is​​​​​Figure 5 Another exploded perspective view of an example cartridge consistent with

[0027] Figure 7 A detail view of a cross-section of a portion of a cartridge assembly consistent with Figures 1-4

[0028] Figure 8 A surface view of an example channel spacer consistent with some examples.

[0029] Figure 9 A partially exploded view of an example cartridge assembly consistent with some examples.

[0030] The present technology can be more fully understood and appreciated by considering the following detailed description of various embodiments, taken in conjunction with the accompanying drawings.

[0031] The drawings are mainly for clarity and, as such, are not necessarily drawn to scale. Moreover, various structures / components, including but not limited to fasteners, electrical components (wiring, cables, etc.), and the like, can be shown schematically or removed from some or all of the views to better illustrate aspects of the depicted embodiments, or inclusion of such structures / components is not necessary for an understanding of the various illustrative embodiments described herein. Lack of illustration / description of such structures / components in a particular drawing, however, should not be construed as limiting the scope of the various embodiments in any way. DETAILED DESCRIPTION

[0032] Cartridge assemblies consistent with the technology disclosed herein can have a variety of different configurations. Figures 1-3C and Figure 6 One example embodiment of a cartridge assembly 110 is shown, and Figures 1-3C and Figure 6 may be viewed in conjunction with the following description. The cartridge assembly 110 is generally configured to filter a fluid passing therethrough. The cartridge assembly 110 generally has an inlet cartridge plate 114, an outlet cartridge plate 120, an inlet plug 126, an outlet plug 128, and a separation layer 130. As shown in Figures 1-3C there are a plurality of cartridges 112 stacked within the cartridge assembly 110. Each of the plurality of cartridges 112 is configured to filter a fluid passing therethrough, and the cartridges 112 are generally arranged in parallel with respect to a fluid flow through the cartridge assembly 110. Parallel fluid flow through a plurality of cartridges can accommodate increased filtration capacity and / or reduced pressure drop as compared to fluid flow through a single cartridge or as compared to fluid flow through cartridges arranged in series. Parallel fluid flow 156 through the assembly 110 is represented in Figure 3A In some embodiments, however, there can be a single cartridge 112 within the cartridge assembly 110, as described further herein.

[0033] As shown in Figure 3B ​As shown, the cartridge assembly 110 has a fluid inlet flow path 122a. The fluid inlet flow path 122a fluidly couples the assembly inlet 110a of the cartridge assembly 110 to each of the cartridges 112 within the assembly 110. The fluid inlet flow path 122a extends axially through each of the cartridges 112 in the cartridge assembly 110. Figure 3C As shown, the cartridge assembly 110 has a fluid outlet flow path 124a. The fluid outlet flow path 124a fluidly couples the assembly outlet 110b of the cartridge assembly 110 to each of the individual cartridges 112 within the assembly. The fluid outlet flow path 124a extends axially through each of the cartridges 112 in the cartridge assembly 110. The fluid inlet flow path 122a and the fluid outlet flow path 124a are in fluid communication through each of the cartridges 112. More specifically, the fluid inlet flow path 122a and the fluid outlet flow path 124a are in fluid communication through each separation layer 130 of each cartridge 112. This disclosure does not limit the flow direction to any particular orientation.

[0034] The box assembly 110 described herein is modular, and users can include different numbers of boxes 112 in the box assembly 110. This can be advantageous because the box assembly 110 can be optimized to adapt to various operating conditions.

[0035] Each box 112 within the box assembly 110 has an inlet box panel 114, an outlet box panel 120, and a separation layer 130 disposed between the inlet box panel 114 and the outlet box panel 120. The outlet box panel 120 may be configured to be stacked with the inlet box panel 114. In some embodiments, the assembly 110 has a single inlet box panel 114 and a single outlet box panel 120 in an assembly having a single box 112. In some embodiments, for example in Figures 1-3C In the components, component 110 includes more than one inlet box plate 114 and more than one outlet box plate 120, wherein component 110 contains more than one box 112.

[0036] Each inlet box plate 114 can define the inlet flow path 116 of the inlet box (especially in Figure 3B (See in) and inlet box outlet flow path 124 ( Figure 3C The inlet box inlet flow path 116 defines the path of inlet fluid flow from component inlet 110a to box 112 during fluid filtration applications. The inlet box outlet flow path 124 defines the path of outlet fluid flow from box 112 during fluid filtration applications. The inlet box inlet flow path 116 may extend axially through inlet box plate 114. The inlet box outlet flow path 124 may extend axially through inlet box plate 114. The inlet box inlet flow path 116 is generally configured for fluid communication with the inlet box outlet flow path 124.

[0037] The outlet cassette plate 120 of each cassette assembly 110 can define an outlet cassette inlet flow path 122 Figure 3B ) and an outlet cassette outlet flow path 118 Figure 3C ). The outlet cassette inlet flow path 122 defines a path for inlet fluid flow during a fluid filtration application. The outlet cassette outlet flow path 118 defines a path for outlet fluid flow during a fluid filtration application. The outlet cassette inlet flow path 122 can extend axially through the outlet cassette plate 120. The outlet cassette outlet flow path 118 can extend axially through the outlet cassette plate 120. The outlet cassette inlet flow path 122 can be generally configured for fluid communication with the inlet cassette inlet flow path 116, as further described herein. The outlet cassette inlet flow path 122 can be generally configured for fluid communication with the outlet cassette outlet flow path 118. The outlet cassette inlet flow path 122 can be generally configured for fluid communication with the inlet cassette outlet flow path 124.

[0038] The inlet cassette inlet flow path 116 can be configured to be laterally aligned with the outlet cassette inlet flow path 122, which together form a portion of a fluid inlet flow path 122a of the assembly 110. "Lateral alignment" is used herein to mean that the inlet flow paths 116, 122 overlap in a lateral direction. The lateral direction is defined as any direction that is orthogonal to the axial direction. The axial direction is parallel to the stacking direction of the inlet cassette plates 114 and the outlet cassette plates 120. In some embodiments, the inlet cassette inlet flow path 116 and the outlet cassette inlet flow path 122 are configured for fluid communication to accommodate fluid flow, e.g., in the axial direction. As such, the fluid inlet flow path 122a can extend axially through the cassette assembly 110, including each inlet cassette plate 114 and each outlet cassette plate 120. Each outlet cassette outlet flow path 118 can be configured to be laterally aligned with each inlet cassette outlet flow path 124, which together form a portion of a fluid outlet flow path 124a of the cassette assembly 110. The fluid outlet flow path 124a extends axially through the cassette assembly 110, including the inlet cassette plates 114 and the outlet cassette plates 120.

[0039] In various embodiments, the inlet cartridge inlet flow path 116 and the outlet cartridge outlet flow path 118 are in fluid communication via a separation layer 130 of the cartridge 112. The separation layer 130 is disposed between the inlet cartridge plate 114 and the outlet cartridge plate 120. The separation layer 130 is generally configured to filter a fluid stream flowing from the inlet cartridge inlet flow path 116 to the outlet cartridge outlet flow path 118. The separation layer is configured to separate at least one component of the fluid stream from the fluid stream. Such separation can be achieved by one or more of the following processes as the fluid flows along and / or through the separation layer: chemical binding, binding of biomolecules, particle capture, absorption, adsorption, etc. The separation layer can comprise a single layer or multiple layers. In some embodiments, the separation layer 130 is a fibrous substance. In some embodiments, the separation layer 130 can be a particulate substance. In some embodiments, the separation layer 130 is a single membrane. In some embodiments, the separation layer 130 is a membrane stack. The membrane stack can comprise multiple membranes layered in succession in an axial direction. The inlet cartridge inlet flow path 116 can be configured to be in fluid communication with the outlet cartridge outlet flow path 118 through the separation layer 130.

[0040] In embodiments where the separation layer 130 comprises a membrane stack, the separation layer 130 can comprise a plurality of membrane layers 131 (shown in Figure 7 In embodiments, the plurality of membrane layers 131 can comprise at least 10 membrane layers 131. In alternative embodiments, the plurality of membrane layers 131 can comprise at least 5, at least 15, at least 19, at least 20, at least 30, at least 40, or at least 50 membrane layers 131, etc. In alternative embodiments, the plurality of membrane layers 131 can comprise less than 50, less than 45, less than 35, less than 25, less than 17, less than 9, less than 4 membrane layers 131, etc.

[0041] The membrane layers 131 can be constructed from a variety of different materials and material combinations. In various embodiments, the membrane layers 131 incorporate a gas permeable membrane, such as polytetrafluoroethylene (PTFE) or other types of gas permeable membranes. The membrane layers 131 can be a laminate or composite material that includes a gas permeable membrane, such as PTFE laminated to a woven or nonwoven support layer. In some embodiments, the membrane layers 131 incorporate a microporous substrate. In some embodiments, each of the membrane layers 131 is constructed from the same or similar materials. In some embodiments, one or more of the membrane layers 131 is constructed from a different material than the other membrane layers 131.

[0042] Figure 7 A detail view of a cross-section of a portion of a cartridge assembly is shown in accordance with Figures 1-3C Each cartridge 112 can further include an inlet channel 136 and an outlet channel 138 (shown in Figure 7 The inlet channel 136 generally defines a flow path from the inlet cartridge inlet flow path 116 (Figure 3B ) along the first lateral surface 134 of the separation layer 130. The outlet channel 138 generally defines a path of fluid flow along the second lateral surface 135 of the separation layer 130 Figure 4 ) that is opposite the first lateral surface 134. The outlet channel 138 extends from the separation layer 130 to the outlet cartridge outlet flow path 118 Figure 4 ). Figure 3C .

[0043] The inlet channel 136 extends along the effective inlet surface area 132a of the separation layer 130. The "effective inlet surface area" 132a is defined as the surface area of the upstream surface of the separation layer 130 that is the first lateral surface 134 exposed to the inlet channel 136. The effective inlet surface area 132a is partially defined by the effective length L4 (illustrated in Figure 7 ). L3 Conversely, the total length of the separation layer 130 is defined by the total length L3 The difference between the total length L4 may be a result of features that block fluid flow through portions of the surface separation layer, such as the separation layer seal 146 (further discussed herein) or structures defined by the cartridge plates 114, 120. The inlet channel 136 can extend laterally from the inlet cartridge inlet flow path 116. The inlet channel 136 can extend axially between the inlet cartridge plate 114 and the effective inlet surface area 132a of the separation layer 130. In some embodiments, the inlet channel 136 can have an axial depth that accommodates axial expansion of the separation layer 130 caused by fluid flow through the separation layer 130, with a portion of the axial depth remaining clear of the separation layer 130 to accommodate fluid flow. In embodiments having a membrane stack, for example, the size of the inlet channel 136 can depend on, for example, the number of membrane layers 131, the materials of the membrane layers 131, the desired fluid flow rate through the assembly 110, and the like.

[0044] The outlet channel 138 extends along the effective outlet surface area 132b of the separation layer 130. An "effective outlet surface area" is defined as the surface area of the downstream surface of the separation layer 130, which is the second lateral surface 135 exposed to the outlet channel 138. The outlet channel 138 can extend laterally toward the outlet cassette outlet flow path 118. The outlet channel 138 can be in fluid communication with the outlet cassette outlet flow path 118. The outlet channel 138 can extend axially between the effective outlet surface area 132b of the separation layer 130 and the outlet cassette plate 120. In some embodiments, the outlet channel 138 can have an axial depth that accommodates axial expansion of the separation layer 130 caused by fluid flow through the separation layer 130, with a portion of the axial depth remaining clear of the separation layer 130 to accommodate fluid flow. In embodiments having a membrane stack, for example, the size of the outlet channel 138 can depend on, for example, the number of membrane layers 131, the material of the membrane layers 131, the desired fluid flow rate through the assembly 110, and the like.

[0045] In some embodiments, the inlet channel 136 can be defined by at least one of the inlet cassette plate 114, the separation layer 130, the effective inlet surface area 132a, and the inlet cassette inlet flow path 116. The outlet channel 138 can be defined by at least one of the outlet cassette plate 120, the separation layer 130, the effective outlet surface area 132b, and the outlet cassette outlet flow path 118. In some embodiments, the channels 136, 138 can be defined by any combination of the listed components, and additionally can be defined by one or more seals discussed further herein.

[0046] Each cassette 112 can further include an inlet flow path extension 117 (e.g., 117a, 117b) and an outlet flow path extension 125 (e.g., 125a, 125b), as shown in FIG. 1 and visible in part in FIG. 2. These extensions are configured to fluidly couple the inlet flow path and the outlet flow path to the inlet channel and the outlet channel, respectively. The inlet flow path extension 117 can be defined by the inlet cassette plate 114. The inlet flow path extension 117 can be configured to fluidly couple the inlet cassette inlet flow path 116 and the inlet channel 136. The inlet flow path extension 117 can include a first portion 117a and a second portion 117b (see FIG. 2). The first portion 117a can extend laterally from the inlet cassette inlet flow path 116 toward the inlet channel 136. In the current example, the second portion 117b extends axially from the first portion 117a to the inlet channel 136. The second portion 117b can be in fluid communication with the inlet channel 136 toward one lateral end of the inlet channel. In some embodiments, the second portion 117b can be in fluid communication with the inlet channel 136 at one lateral end of the inlet channel 136. Figures 3A-3C Figure 7 The outlet flow path extension 125 can be defined by the outlet cassette plate 120. The outlet flow path extension 125 can be configured to fluidly couple the outlet cassette outlet flow path 118 and the outlet channel 138. The outlet flow path extension 125 can include a first portion 125a and a second portion 125b (see FIG. 2). The first portion 125a can extend laterally from the outlet cassette outlet flow path 118 toward the outlet channel 138. In the current example, the second portion 125b extends axially from the first portion 125a to the outlet channel 138. The second portion 125b can be in fluid communication with the outlet channel 138 toward one lateral end of the outlet channel. In some embodiments, the second portion 125b can be in fluid communication with the outlet channel 138 at one lateral end of the outlet channel 138. Figure 3B ​​

[0047] An outlet flow path extension 125 can be defined by the outlet cassette plate 120. The outlet flow path extension 125 can fluidly couple the outlet cassette outlet flow path 118 and the outlet passage 138. The outlet flow path extension 125 can include a first portion 125a and a second portion 125b (see FIG. 4). The first portion 125a can extend axially from the outlet passage 138 to the second portion 125b. The second portion 125b can extend laterally from the first portion 125a to the outlet cassette outlet flow path 118. The first portion 125a can be fluidly coupled to the outlet passage 138 toward an opposite end of the effective length of the separation layer 130 (shown in FIG. 3) relative to the inlet extension first portion 117a. Figure 3C Figure 3C Figure 7 Figure 3C L4 Figure 7

[0048] In alternative embodiments, the extensions do not define 90 degree segments relative to one another or the corresponding fluid flow paths as shown, but can define one or more curved segments. In further alternative embodiments, the inlet extension is a single segment extending from the inlet cassette inlet flow path 116 to the inlet passage 136 at an oblique angle such that the inlet extension is not orthogonal to the inlet cassette inlet flow path 116 or the inlet passage 136. Similarly, the outlet extension 125 can define a single or multiple segments, at least one of which is curved. In some embodiments, the outlet extension is a single segment defining an oblique angle and extending from the outlet passage 138 to the outlet cassette outlet flow path 118 such that the outlet extension is not orthogonal to the outlet cassette outlet flow path 118 or the outlet passage 138.

[0049] The inlet cassette plate 114 and the outlet cassette plate 120 can be constructed of a variety of different materials and combinations of materials. In some embodiments, one or both of the cassette plates 114, 120 is plastic. In other embodiments, one or both of the cassette plates 114, 120 is metal. In one example, one or both of the cassette plates 114, 120 is injection molded, 3D printed, machined, or a combination thereof. In some embodiments, the inlet cassette plate 114 is constructed of the same material as the outlet cassette plate 120. In some other embodiments, the inlet cassette plate 114 is constructed of a different material than the outlet cassette plate 120.

[0050] Figure 8 ​​​​​​A transverse face view of an example channel spacer is shown, which can be inserted into the inlet channel 136 and / or the outlet channel 138 to ensure, for example, that the separation layer 130 does not swell into the channel and block the channel. Each cartridge 112 can further include one or more channel spacers 140, 142 that are each configured to be received by the inlet channel 136 and / or the outlet channel 138. In the current example, the cartridge assembly 110 has an inlet channel spacer 140 (as shown in Figures 7-8 The inlet channel spacer 140 is generally configured to maintain a minimum axial depth of the inlet channel 136 to maintain fluid flow along the inlet channel 136. As mentioned above, the axial depth of the inlet channel 136 can decrease over time as the system is used, for example, due to swelling of the separation layer, and the inlet channel spacer 140 can advantageously resist such swelling. The inlet channel spacer 140 can be positioned in the inlet channel 136. The inlet channel spacer 140 is between the inlet cartridge plate 114 and the separation layer 130. In some embodiments, the inlet channel spacer 140 abuts the inlet cartridge plate 114 and the separation layer 130.

[0051] Each cartridge 112 can further include an outlet channel spacer 142. The outlet channel spacer 142 is generally configured to maintain a minimum axial depth of the outlet channel 138 to accommodate fluid flow along the outlet channel 138. The axial depth of the outlet channel 138 can decrease over time as the system is used, for example, due to swelling of the separation layer, and the outlet channel spacer 142 can advantageously resist such swelling. The outlet channel spacer 142 can be positioned in the outlet channel 138. The outlet channel spacer 142 is between the outlet cartridge plate 120 and the separation layer 130. In some embodiments, the outlet channel spacer 142 abuts the outlet cartridge plate 120 and the separation layer 130.

[0052] The inlet channel spacer 140 and / or the outlet channel spacer 142 can be constructed from a variety of different materials and combinations of materials. In some embodiments, the spacers 140, 142 are plastic. The spacers can be a woven or non-woven material, such as a scrim layer. In other embodiments, the spacers 140, 142 are metal. In one example, the spacers 140, 142 are injection molded, 3D printed, etc. The spacers 140, 142 can be constructed from an elastomeric material, such as rubber, silicone, polyurethane, or other elastomeric material. The spacers 140, 142 can be held by frictional and / or compressive forces. Such frictional forces can be between, for example, the spacers 140, 142 and the separation layer 130, and between the spacers 140, 142 and the respective cartridge plates 114, 120.

[0053] Channel spacers 140, 142 generally define lateral and axial openings to accommodate fluid flow through channel spacers 140, 142 to separation layer 130. In some embodiments, at least one of the inlet channel spacer 140 and the outlet channel spacer 142 may include a lateral ridge 144 extending across separation layer 130, one example of which is... Figure 8 As shown in the diagram. The transverse ridge 144 is generally configured to define a structure to maintain the axial depth of the corresponding channel for fluid flow. The transverse ridge 144 can advantageously provide rigidity to the corresponding spacer. The transverse ridge 144 can further advantageously guide the fluid flow across the corresponding surface area of ​​the separation layer 130.

[0054] The transverse ridge 144 may extend laterally along at least a portion of the channel length of the corresponding channel in which the spacer is positioned. The transverse ridge 144 may extend axially between the separation layer 130 and the adjacent box panel.

[0055] Each box 112 may further include a separation layer seal 146 ( Figures 3B-3C , Figure 4 and Figure 7 The separation layer seal 146 is generally configured to seal between the separation layer and each of the inlet box plate 114 and the outlet box plate 120, preventing fluid from escaping between the plates during fluid filtration. The separation layer seal 146 may be installed between the inlet box plate 114 and the outlet box plate 120. In some embodiments, the separation layer seal 146 may contact both the inlet box plate 114 and the outlet box plate 120. The separation layer seal 146 may be configured to fluidly seal the peripheral region 130a of the separation layer 130 (in...). Figure 7 The middle portion is visible), the peripheral area of ​​the inlet channel 136 (not shown), and the peripheral area of ​​the outlet channel 138 (not shown). In some embodiments, the separation layer seal 146 is defined by the relatively tight coupling of the housing plates 114, 120, which forms a liquid-tight seal via compressive forces around the separation layer 130. In such examples, the separation layer seal, as a component independent of the housing plates 114, 120, can be omitted.

[0056] The release layer seal 146 can be made of a variety of different materials and combinations thereof. In various embodiments, the release layer seal 146 can be made of an elastic material, such as rubber, polysiloxane / silicone, polyurethane, etc. In some other embodiments, the release layer seal 146 is molded plastic. In still other embodiments, the release layer seal 146 is metal. In one example, the release layer seal 146 is injection molded, 3D printed, or formed by other types of processes. The release layer seal 146 may include an overmolded gasket. The overmolded gasket may be injection molded around the periphery of the release layer 130 to form the release layer seal 146.

[0057] In alternative embodiments, the separator seal may be more than one seal. Separator seal 146 may include a first O-ring inserted between a peripheral region 130a on a first lateral surface 134 (e.g., the upstream surface) of separator 130 and the inlet box plate 114. Separator seal 146 may include a second O-ring inserted between a peripheral region 130a on a second lateral surface 135 (e.g., the downstream surface) of separator 130 and the outlet box plate 120. In further alternative embodiments, separator seal 146 may be, for example, a weld or an adhesive. Welds may be formed between boxes 114, 120, or between separator 130 and the inlet box plate 114, or between separator 130 and the outlet box plate 120, or any combination thereof, or adhesives may be used to seal boxes 114, 120, or separator 130 to the inlet box plate 114, or separator 130 to the outlet box plate 120, or any combination thereof.

[0058] like Figure 4 As shown, in some embodiments, the inlet cassette 114 and the outlet cassette 120 together define a compression structure 147 surrounding the inlet channel 136 and the outlet channel 138. More specifically, in the present example, the outlet cassette 120 defines an axially extending sidewall 147a surrounding the outlet channel 138, which faces the opposing sidewall 147b of the inlet cassette 114 surrounding the inlet channel 136. The axially extending sidewall 147a and the opposing sidewall 147b apply compressive forces on the peripheral region 130a of the separation layer 130, forming a fluid seal. The compression structure 147 advantageously prevents fluid from bypassing it.

[0059] Each box 112 may further include an attachment seal 158 ( Figures 3B-3C and Figure 4 The attachment seal 158 is generally configured to provide a fluid seal between the inlet box plate 114 and the outlet box plate 120. The attachment seal 158 can be inserted between the inlet box plate 114 and the outlet box plate 120. The attachment seal 158 can extend laterally around and outside the periphery of the separation layer 130. The attachment seal 158 can be laterally positioned on the respective axial surfaces 115a, 115b of the inlet box plate 114 and the outlet box plate 120. Figures 1-2 The attachment seal 158 is located between the attachment seal 158 and the release layer seal 146. The attachment seal 158 may be constructed from various materials and combinations thereof, consistent with those discussed above regarding the attachment layer seal. The attachment seal 158 may be held, for example, by frictional and / or compressive forces, and / or may be held using fasteners 172. Such forces may exist between the attachment seal 158, the first housing plate 114, and the second housing plate 120.

[0060] In some embodiments, each inlet panel 114 may define a first port 148 (especially in Figure 3BA first port 148 can be defined in the inlet cartridge 110. The first port 148 can be configured to receive a sample fluid or remove gas once the cartridge assembly 110 has been assembled and / or fluid filtration has begun. The first port 148 can be in selective fluid communication with the inlet cartridge inlet flow path 116. The first port 148 can extend laterally through an axial surface 115a of the inlet cartridge plate 114. The first port 148 can extend laterally from the axial surface 115a to the inlet cartridge inlet flow path 116. The first port 148 can be axially aligned with the inlet flow path extension 117. "Axially aligned" is used herein to mean that the first port 148 and the inlet flow path extension 117, particularly the first portion 117a, overlap in the axial direction. The first port 148 and the first portion 117a of the inlet flow path extension 117 can be configured for fluid communication to receive a fluid flow, e.g., in the lateral direction. The cartridge assembly 110 can further include a first port plug 149. The first port plug 149 can be configured to seal the first port 148. The first port plug 149 can be removable and reinsertable in the first port 148. In some embodiments, the first port plug 149 is configured to be permanently sealably disposed in the first port 148.

[0061] The outlet cartridge plate 120 can define a second port 150 in selective fluid communication with the outlet cartridge outlet flow path 118. The second port 150 can extend laterally through an axial surface 115b of the outlet cartridge plate 120. The cartridge assembly 110 can further include a second port plug 151. The second port plug 151 can be configured to seal the second port 150. The second port plug 151 can be removable and reinsertable in the second port 150. In some embodiments, the second port plug 151 is configured to be permanently sealably disposed in the second port 150.

[0062] The port plugs 149, 151 can be constructed of a variety of different materials and combinations of materials. In some embodiments, the port plugs 149, 151 are molded plastic. In other embodiments, the port plugs 149, 151 are metal. In one example, the port plugs 149, 151 are injection molded, 3D printed, etc. The port plugs 149, 151 can be constructed using, e.g., rubber, silicone, polyurethane, or other elastomeric materials. The port plugs 149, 151 can be constructed of a combination of materials, e.g., metal with a plastic and / or elastomeric coating. In some embodiments, the port plugs 149, 151 can be threaded and screwed into the ports 148, 150, as Figures 3A-3CPort plugs 149, 151 can define threads in such embodiments. Port plugs 149, 151 can each have a head 149a, 151a that mates with, for example, mating features of one or more tools, such as a screwdriver or wrench. The port plugs 149, 151 can be removed by unscrewing them from the ports 148, 150. In Figures 1-2 In the current example seen in FIGS. 1 1-13, the port plugs 149, 151 have hexagonal heads that, for example, align with mating features of a wrench for removal and reinsertion.

[0063] Cartridge assemblies consistent with the technology disclosed herein can have a variety of different configurations. Figures 5-6 A relative exploded perspective view of another example cartridge 212 is shown, and Figures 5-6 may be viewed in conjunction with the following description. The cartridge 212 is generally configured to filter fluid passing therethrough. The cartridge 212 generally has an inlet cartridge plate 214, an outlet cartridge plate 220, and a separation layer 230.

[0064] The cartridge 212 described herein is modular, and although the components shown in the current figures are a single cartridge 212, different numbers of cartridges 212 can be incorporated into a cartridge assembly, similar to Figures 1-4 and Figure 7 the embodiments described in FIGS. 1-10. This can be advantageous because the cartridge assembly can be optimized to accommodate a variety of different operating conditions. It should be understood that, unless contradicted by the current description or corresponding figures, the components referenced in the description herein Figures 5-6 are consistent with the description of the same components described elsewhere herein.

[0065] Similar to other embodiments described herein, the cartridge 212 has an inlet cartridge plate 214, an outlet cartridge plate 220, and a separation layer 230 disposed between the inlet cartridge plate 214 and the outlet cartridge plate 220. The outlet cartridge plate 220 can be configured in a stacked arrangement with the inlet cartridge plate 214. Each inlet cartridge plate 214 can define an inlet cartridge inlet flow path 216 and an inlet cartridge outlet flow path 224. The inlet cartridge inlet flow path 216 defines a path for inlet fluid flow into the cartridge 212 during a fluid filtration application. The inlet cartridge outlet flow path 224 defines a path for outlet fluid flow out of the cartridge 212 during a fluid filtration application. The inlet cartridge inlet flow path 216 can extend axially through the inlet cartridge plate 214. The inlet cartridge outlet flow path 224 can extend axially through the inlet cartridge plate 214. The inlet cartridge inlet flow path 216 is generally configured for fluid communication with the inlet cartridge outlet flow path 224.

[0066] The outlet cassette plate 220 can define an outlet cassette inlet flow path 222 and an outlet cassette outlet flow path 218. The outlet cassette inlet flow path 222 defines a path of inlet fluid flow during a fluid filtration application. The outlet cassette outlet flow path 218 defines a path of outlet fluid flow during a fluid filtration application. The outlet cassette inlet flow path 222 can extend axially through the outlet cassette plate 220. The outlet cassette outlet flow path 218 can extend axially through the outlet cassette plate 220. The outlet cassette inlet flow path 222 can be generally configured for fluid communication with the inlet cassette inlet flow path 216, as described further herein. The outlet cassette inlet flow path 222 can be generally configured for fluid communication with the outlet cassette outlet flow path 218. The outlet cassette inlet flow path 222 can be generally configured for fluid communication with the inlet cassette outlet flow path 224.

[0067] The inlet cassette inlet flow path 216 can be configured to be laterally aligned with the outlet cassette inlet flow path 222, as described above in connection with Figures 1-4 and Figure 7 . Each outlet cassette outlet flow path 218 can be configured to be laterally aligned with each inlet cassette outlet flow path 224, as described above in connection with Figures 1-4 and Figure 7 .

[0068] In various embodiments, the inlet cassette inlet flow path 216 and the outlet cassette outlet flow path 218 are in fluid communication via a separation layer 230 of the cassette 212. The separation layer 230 is disposed between the inlet cassette plate 214 and the outlet cassette plate 220. The separation layer 230 is generally configured to filter fluid flow from the inlet cassette inlet flow path 216 to the outlet cassette outlet flow path 218. The inlet cassette inlet flow path 216 can be configured to be in fluid communication with the outlet cassette outlet flow path 218 through the separation layer 230. The separation layer 230 can include a membrane stack, which can further include a plurality of membrane layers, as described herein in connection with Figures 1-4 and Figure 7 .

[0069] Each cassette 212 can further include an inlet channel 236 (as shown in Figure 6 ) and an outlet channel 238 (as shown in Figure 5 ). The inlet channel 236 generally defines a path of fluid flow from the inlet cassette inlet flow path 216 along a first lateral surface 234 (as Figure 5 ) of the separation layer 230. The outlet channel 238 generally defines a path of fluid flow along a second lateral surface 235 (as Figure 6 ) of the separation layer 230, which is opposite the first lateral surface 234. The outlet channel 238 extends from the separation layer 230 to the outlet cassette outlet flow path 218.

[0070] Inlet channel 236 Figure 6 extends along an effective inlet surface area 232a Figure 5 of separation layer 230. "Effective inlet surface area" 232a is defined as the surface area of the upstream surface of separation layer 230 that is the first lateral surface 234 directly exposed to inlet channel 236. Inlet channel 236 is similar to inlet channel 136 described herein in connection with Figures 1-4 and Figure 7 . Outlet channel 238 Figure 5 extends along an effective outlet surface area 232b Figure 6 of separation layer 230. "Effective outlet surface area" is defined as the surface area of the downstream surface of separation layer 230 that is the second lateral surface 235 exposed to outlet channel 238. Outlet channel 238 is similar to outlet channel 138 described herein in connection with Figures 1-4 and Figure 7 .

[0071] Each cartridge 212 can further include an inlet flow path extension and an outlet flow path extension, similar to those described herein in connection with Figures 3A-3C and partially visible in Figure 7 . For example, Figure 5 illustrates an outlet flow path extension first portion 225a, and Figure 6 illustrates an inlet flow path extension second portion 217b. Second portion 217b can extend laterally along at least a portion of the width W1 of inlet channel 236 (as illustrated in Figure 6 ). This can advantageously improve fluid flow uniformity across the entire effective area of separation layer 230. Similarly, in the present example, first portion 225a can extend laterally along at least a portion of the width W2 of outlet channel 238 (as illustrated in Figure 5 ). Such a configuration can advantageously improve fluid flow uniformity across the entire effective area of separation layer 230. Alternative examples are possible in which one or both of the second portion 217b of the inlet flow path extension and the first portion 225a of the outlet flow path extension define an opening having a circular shape rather than an elongated slot.

[0072] Inlet channel 236 of inlet cartridge plate 214 defines an inlet channel length L1 and an inlet channel width W1 , as illustrated in Figure 6 . In some embodiments, the ratio of inlet channel length L1 to inlet channel width W1 may advantageously result in a relative improvement in flow characteristics in a filtration operation. Inlet channel length L1 may be less than inlet channel widthW1 One to four times that of the previous. In an alternative embodiment, the inlet channel length is... L1 It can be the width of the entrance passage. W1 At least 1 time, at least 1.5 times, at least 2 times, at least 2.5 times, at least 3 times, at least 3.5 times, at least 4 times, etc., and / or may be the width of the entrance passage. W1 Less than 4 times, less than 3.75 times, less than 3.25 times, less than 2.75 times, less than 2.25 times, less than 1.75 times, less than 1.25 times, etc.

[0073] The outlet channel 238 of the outlet box plate 220 can limit the length of the outlet channel. L2 and the width of the exit channel W2 ,like Figure 5 As shown in the figure. Length of the exit channel. L2 With the width of the exit channel W2 The ratio can be combined with the above to determine the entrance channel length. L1 and entrance channel width W1 The ratios discussed are consistent.

[0074] The separation layer 230 generally defines an effective inlet surface region 232a and an effective outlet surface region 232b. The effective inlet surface region 232a has an effective length. L4 and effective width W4 ( Figure 6 The effective inlet surface area 232a can be defined as the area of ​​the separation layer 230 that can be used for filtration. The effective inlet surface area 232a is generally smaller than the total surface area of ​​the separation layer 230. The separation layer can be defined in terms of its total length. L3 ( Figure 5 ) and total width W3 ( Figure 6 In the current example, the peripheral area of ​​the separation layer 230 is sandwiched between the inlet box plate 214 and the outlet box plate 220 and cannot be used for filtering, thus not defining a portion of the effective area.

[0075] Effective length L4 It can be the effective width W4 One to four times that of [previous length]. In alternative embodiments, the effective length [is...]. L4 It can be the effective width W4 At least 1 time, at least 1.5 times, at least 2 times, at least 2.5 times, at least 3 times, at least 3.5 times, or at least 4 times, etc. In alternative embodiments, the effective length... L4 It can be the effective width W4 Less than 4 times, less than 3.75 times, less than 3.25 times, less than 2.75 times, less than 2.25 times, less than 1.75 times, or less than 1.25 times, etc.

[0076] In some embodiments, effective width W4 It is equal to the width of the effective inlet surface region 232a and the width of the effective outlet surface region 232b. In an alternative embodiment, the effective width... W4 The effective inlet surface region 232a may differ from the effective outlet surface region 232b, resulting in an effective inlet width and an effective outlet width (not shown). In some embodiments, the effective length... L4 This is equal to the length of the effective inlet surface region 232a and the length of the effective outlet surface region 232b. In an alternative embodiment, the effective length of the effective inlet surface region 232a is... L4 The effective length can be different from that of the effective outlet surface region 232b, resulting in an effective inlet length and an effective outlet length (not shown).

[0077] Each box 212 may further include one or more channel spacers, each configured to be received by an inlet channel 236 and / or an outlet channel 238. In the current example, box 212 has an inlet channel spacer 240 (e.g., Figures 5-6 (As shown). The entrance channel spacer 240 can be similarly combined. Figures 1-4 and Figure 7 The described inlet channel spacer 140. Each box 212 may further include an outlet channel spacer (for...). Figures 5-6 (Not shown for clarity). The outlet channel spacer can be similar to a combination. Figures 1-4 and Figure 7 The described exit channel spacer 142.

[0078] Each cartridge 212 may further include a separation layer seal 246. The separation layer seal 246 is generally configured to seal between the separation layer and each of the inlet cartridge plate 214 and the outlet cartridge plate 220, preventing fluid from escaping between the plates during fluid filtration. The separation layer seal 246 may be installed between the inlet cartridge plate 214 and the outlet cartridge plate 220. In some embodiments, the separation layer seal 246 may contact the inlet cartridge plate 214 and the outlet cartridge plate 220. The separation layer seal 246 may be configured to fluidly seal the peripheral region 230a of the separation layer 230. Figure 5 ), the surrounding area 236a of entrance passage 236 ( Figure 6 ) and the surrounding area 238a of the exit passage 238 ( Figure 5 The separation layer seal 246 can be similar to a combination. Figures 1-4 and Figure 7 The described separation layer seal 146.

[0079] Each cartridge 112 can further include an attachment seal 258. The attachment seal 258 is generally configured to fluidly seal between the inlet cartridge plate 214 and the outlet cartridge plate 220. The attachment seal 258 can be inserted between the inlet cartridge plate 214 and the outlet cartridge plate 220. The attachment seal 258 can extend laterally around the periphery of the separation layer seal 246. The attachment seal 258 can be similar to the attachment seal 158 described herein in connection with Figures 1-4 and Figure 7 .

[0080] In some embodiments, each inlet cartridge plate 214 can define a first port, similar to the first port 148 described herein in connection with Figures 1-4 and Figure 7 . The cartridge 212 can further include a first port plug 249. The first port plug 249 can be configured to seal the first port. The first port plug 249 can be removable and re-insertable into the first port. In some embodiments, the first port plug 249 is configured to be permanently sealably disposed in the first port.

[0081] The outlet cartridge plate 220 can define a second port, similar to the second port 150 described herein in connection with Figures 1-4 and Figure 7 . The cartridge 212 can further include a second port plug 251. The second port plug 251 can be configured to seal the second port. The second port plug 251 can be removable and re-insertable into the second port. In some embodiments, the second port plug 251 is configured to be permanently sealably disposed in the second port. The port plugs 249, 251 can be constructed of various different materials and combinations of materials, and can be configured with various threads, etc., as discussed herein in connection with Figures 1-4 and Figure 7 .

[0082] The outlet cartridge plate 220 can include an alignment feature 252. The inlet cartridge plate 214 can include a mating alignment feature 254 configured to mate with the alignment feature 252 when the cartridge plates 214, 220 are properly aligned and stacked. Figure 5 and Figure 6 The mating alignment feature 254 is shown configured as one or more pins, and the alignment feature 252 is shown configured as one or more corresponding cylindrical receptacles. In some embodiments, the mating alignment feature can be integral with one of the cartridge plates 214, 220. In some other embodiments, the alignment feature can be a separate component (e.g., pins, screws / bolts, etc.) that is collectively received by the openings defined by the outlet cartridge plate 220 and the inlet cartridge plate 214. The alignment feature 252 and the mating alignment feature 254 can have similar configurations as the alignment feature 152 and the mating alignment feature 154 described herein in connection with Figure 9Further described are alternative configurations of alignment features and mating alignment features or additional components.

[0083] Figure 9 is a schematic exploded view of some components of an alternative example cartridge assembly 310 having an alternative example cartridge 312 consistent with the technology disclosed herein. The cartridge 312 has an inlet cartridge plate 314 and an outlet cartridge plate 320. It should be appreciated that the description of components referenced in the description of the cartridge 312 below are consistent with the description of the same components described elsewhere herein, unless contradicted by the current description or corresponding drawings. Figure 9

[0084] The outlet cartridge plate 320 can include an alignment feature 352. The inlet cartridge plate 314 can include a mating alignment feature 354 configured to mate with the alignment feature 352 when the cartridge plates 314, 320 are properly aligned and stacked. The alignment feature 352 is configured to be laterally aligned with the mating alignment feature 354. The alignment feature 352 and the mating alignment feature 354 can help operatively couple the outlet cartridge plate 320 and the inlet cartridge plate 314. The alignment feature 352 and the mating alignment feature 354 can advantageously guide a user to correctly stack the various cartridge plates in order to assemble the cartridge. In some embodiments, the alignment feature 352 can include a protrusion, while the mating alignment feature can include a receptacle configured to receive the protrusion, although the opposite configuration is also contemplated. In some alternative embodiments, the alignment feature 352 can form a snap fit with the mating alignment feature 354. In other alternative embodiments, the alignment feature 352 can include a visual indicator, such as a marking configured to align with the mating alignment feature 354, or vice versa. The alignment feature 352 and the mating alignment feature 354 will be described in more detail below with respect to cartridge assembly configurations. Figure 9 .

[0085] One or more cartridges 112 can be arranged in a stacked configuration to form a cartridge assembly 110 consistent with the technology disclosed herein, one example of which is illustrated in Figures 1-4 ​The cartridge assembly 110 has one or more cartridges 112, where each of the cartridges 112 is consistent with the above discussion. In the stacked configuration, each inlet cartridge inlet flow path 116 of each inlet cartridge plate 114 is laterally aligned with each outlet cartridge inlet flow path 122 of each outlet cartridge plate 120. Each inlet cartridge inlet flow path 116 can be sealingly coupled to at least one outlet cartridge inlet flow path 122. Similarly, in the stacked configuration, each inlet cartridge outlet flow path 124 is laterally aligned with each outlet cartridge outlet flow path 118. The inlet flow paths 116, 122 of each of the cartridges 112 cumulatively define a substantial portion of a fluid inlet flow path 122a of the cartridge assembly 110. Similarly, the outlet flow paths 118, 124 cumulatively define a substantial portion of a fluid outlet flow path 124a of the cartridge assembly 110.

[0086] The cartridge assembly 110 has a first cartridge plate 190 and a last cartridge plate 192 (e.g., a final cartridge plate) that are laterally aligned with each other. Figure 1 , Figure 3B and Figure 3C ). The first cartridge plate 190 is an outermost inlet cartridge plate 114 in the cartridge stack. The last cartridge plate 192 is an outermost outlet cartridge plate 120 in the cartridge stack. In embodiments where the cartridge assembly 110 has a single cartridge 112, the first cartridge plate 190 is the inlet cartridge plate 114 and the last cartridge plate 192 is the outlet cartridge plate 120. Notably, the inlet cartridge outlet flow path 124 of the first cartridge plate 190 (which can be referred to as a first inlet cartridge outlet flow path 191 ( Figure 3C )) defines a non-active space / volume of the fluid outlet flow path 124a. In particular, fluid flow from the separation layer of each of the cartridges 112 is directed via the fluid outlet flow path 124a to the assembly outlet 110b and the first inlet cartridge outlet flow path 191 is not positioned to receive such fluid flow (e.g., from a preceding cartridge in the stack). Similarly, the outlet cartridge inlet flow path 122 of the last cartridge plate 192 (which can be referred to as a last outlet cartridge inlet flow path 193 ( Figure 3B )) defines a non-active space / volume of the fluid inlet flow path 122a as the last outlet cartridge inlet flow path 193 is not positioned to direct fluid to a subsequent cartridge. Such non-active / space / volume of the first inlet cartridge outlet flow path 191 and the last outlet cartridge inlet flow path 193 can negatively impact filtration operations, for example, introducing unpredictability in fluid flow or aggregating fluid that can become stagnant.

[0087] In various embodiments, the cartridge assembly 110 has an inlet plug 126 and an outlet plug 128. The inlet plug 126 can be configured to be inserted into the last outlet cartridge inlet flow path 193 to seal the last outlet cartridge inlet flow path 193 (e.g., Figure 3B As shown in the diagram, fluid flow entering the inlet of cartridge assembly 110 is directed through cartridge 112. Inlet plug 126 is configured to be removable and re-inserted into the last outlet cartridge inlet flow path 193. Outlet plug 128 is configured to be inserted into the first inlet cartridge outlet flow path 191 to seal the first inlet cartridge outlet flow path 191, causing fluid flow from the cartridge to be directed to assembly outlet 110b. Outlet plug 128 is configured to be removable and re-inserted into the first inlet cartridge outlet flow path 191.

[0088] The inlet plug 126 can be inserted by pushing it into the inlet flow path 193 of the last outlet box. Similarly, the outlet plug 128 can be inserted by pushing it into the outlet flow path 191 of the first inlet box. Each plug 126, 128 can be made of various different materials and combinations of materials. In some embodiments, plugs 126, 128 are plastic components. In other embodiments, one or both of plugs 126, 128 are made of metal. In one example, plugs 126, 128 are injection molded, 3D printed, or made of other materials. Plugs 126, 128 can be made of, for example, rubber, polysiloxane / silicone, polyurethane, or other elastic materials. In some embodiments, inlet plug 126 and outlet plug 128 are made of the same material; in other embodiments, inlet plug 126 and outlet plug 128 are made of different materials. Plugs 126, 128 are configured to frictionally engage corresponding box plates 190, 192 that receive the plug. In some embodiments, the plugs may sealably engage with corresponding housing plates 190, 192 that receive plugs 126, 128. The plugs can be removed by pulling the plugs 126, 128 out of their respective paths 122, 118 or by pushing the plugs forward through the paths until the plugs are pushed through their respective housing plates 114, 120 and away from their respective flow paths 122, 118 at their inserted opposite ends.

[0089] In some embodiments, the inlet plug 126 and outlet plug 128 may be configured as solid cylindrical plugs. In other embodiments, plugs 126, 128 may be threaded, similar to the port plugs discussed above. In a later example, plugs 126, 128 can be removed and reinserted by twisting the plugs relative to the housing on which they are mounted. In alternative embodiments, plugs 126, 128 may be configured as snap-fit ​​plugs entering their respective paths 122, 118, or may further alternatively be configured as solidifiable liquids that solidify within their respective paths 122, 118.

[0090] Plugs 126 and 128 can each advantageously fill the fluid-coupled path and the corresponding inactive space / volume within the cartridge. This configuration advantageously prevents fluid from entering the inactive space / volume during filtration operation, which improves filtration performance and maximizes the amount / volume of filtered fluid. Additionally, in some embodiments, one or both of plugs 126 and 128 are completely accommodated by their respective paths 122 and 118, such that the plug does not protrude outward from the cartridge 112. This configuration advantageously allows for a relatively compact profile of the cartridge assembly 110 and also advantageously eliminates the need for, for example, external devices to close or block paths 122 and 118.

[0091] The box assembly 110 may further include a first end plate 160 and a second end plate 162, such as Figures 1-3C As shown in the diagram, a first end plate 160 is operatively coupled to an inlet cassette plate 114. Generally, the first end plate 160 is coupled to a first cassette plate 190 of the cassette assembly 110. A second end plate 162 is operatively coupled to an outlet cassette plate 120 of the cassette 112. Generally, the second end plate 162 is coupled to a last cassette plate 192 of the cassette assembly 110. The end plates 160, 162 advantageously provide rigidity and structure to the entire assembly 110, and also advantageously provide greater resistance to internal pressures caused by fluid filtration.

[0092] The first end plate 160 may include a first entry port 164. Figures 3A-B). The first inlet port 164 can be configured to extend to the inlet cartridge inlet flow path 116 of the first cartridge plate 190. The first inlet port 164 is generally configured for fluid communication with the first inlet cartridge inlet flow path 116. More specifically, the first inlet port 164 defines a fluid flow path configured to extend from the assembly inlet 110a to the first inlet cartridge inlet flow path 116. The second end plate 162 can include a second outlet port 170. The second outlet port 170 is generally configured for fluid communication with the last outlet cartridge outlet flow path 118. The second outlet port 170 can be configured to extend from the last outlet cartridge outlet flow path 118 to the assembly outlet 110b. More specifically, the second outlet port 170 defines a fluid flow path through which fluid exits from the last outlet cartridge outlet flow path 118 of the assembly 110 through the assembly outlet 110b.

[0093] A syringe, tube, or other tool can be used to direct fluid to the cartridge assembly 110. Such a tool can include a mating component, such as a luer lock, configured to sealably engage one or both of the first inlet port 164 and the second outlet port 170. In alternative embodiments, the first inlet port 164 and the second outlet port 170 can be configured to mate with, for example, tubes, syringes, or needles of various sizes. In other alternative embodiments, the first inlet port 164 and the second outlet port 170 can be configured to be closable or sealable, and can further be configured to be re-openable or re-sealable.

[0094] The cartridge assembly 110 can further include a fastener 172 ( Figure 1 ). The fastener 172 is generally configured to hold components of the cartridge assembly 110 in an operational configuration. The fastener 172 can be configured to operatively couple the inlet cartridge plate 114 and the outlet cartridge plate 120. In embodiments having more than one cartridge 112, the fastener 172 can operatively couple each of the cartridge plates. In the current example, the fastener 172 includes a bolt 174. In some embodiments, the inlet cartridge plate 114 can define a first axial through-hole (not currently visible). The outlet cartridge plate 120 can define a second axial through-hole (not currently visible). The first and second axial through-holes can be configured to be laterally aligned with one another to accommodate the bolt 174. There can be more than one bolt 174, and correspondingly, more than one aligned through-hole to accommodate the more than one bolt 174.

[0095] In embodiments having first end plate 160 and / or second end plate 162, fastener 172 can be configured to operatively couple first end plate 160, inlet cartridge plate 114, outlet cartridge plate 120, and second end plate 162. First end plate 160 can define a third axial through-hole 180, and second end plate 162 can define a fourth axial through-hole 182 (as shown in Figure 1 Each of the first, second, third, and fourth axial through-holes can be configured to be laterally aligned with one another to accommodate bolt 174. In some embodiments, at least one of the first, second, third, and fourth axial through-holes can include a threaded hole configured to engage bolt 174.

[0096] In examples consistent with embodiments shown in Figures 1-3C In the current example, such fastener 172 does not directly engage any of the cartridges. Cartridge 112 is compressibly contained by end plates 160, 162. In particular, once fastener 172 is engaged, end plates 160, 162 are configured to exert a compressive force on cartridge 112 in the axial direction, which results in a relatively fixed stack of cartridges 112.

[0097] In particular examples of Figures 1-3C Cartridge assembly 110 has fastener 172 that includes a plurality of bolts, where each bolt has a first nut 184 and a second nut 186. First nut 184 can be configured to accommodate a first end of bolt 174. Second nut 186 can be configured to accommodate an opposite second end of bolt 174. First nut 184 and second nut 186 can be configured to exert a compressive force on cartridge assembly 110. Nuts 184, 186 can in particular exert a compressive force on operatively coupled end plates 160, 162 via bolts 174. First nut 184 can be in contact with first end plate 160, and second nut 186 can be in contact with second end plate 162, or vice versa. Accordingly, nuts 184, 186 can exert a compressive force on first end plate 160 and second end plate 162. Accordingly, end plates 160, 162 exert a compressive force on the stack of cartridges, which can advantageously seal each of the one or more fluid flow paths through cartridges 112. In alternative embodiments, fastener 172 can include various clamps, bolts, snap fits, lacing, etc., which can exert a compressive force as described herein.

[0098] In other alternative embodiments, the fastener 172 can include at least one threaded bolt that can be threadably engaged with at least one threaded hole defined by at least one of the inlet cassette plate 114, the outlet cassette plate 120, the first end plate 160, and the second end plate 162. In embodiments where the at least one threaded bolt is engaged with the at least one threaded hole, at least one of the first nut 184 and the second nut 186 can not be necessary. At least one of the first nut 184 and the second nut 186 can not be necessary due to the threaded engagement between the threaded bolt and the threaded hole.

[0099] Again returning to Figure 9 , the inlet cassette plate 314 can define a first axial through hole 376. The outlet cassette plate 320 can define a second axial through hole 378. The first axial through hole 376 and the second axial through hole 378 can be configured to be laterally aligned with one another to accommodate a fastener, such as a pin, a screw, a bolt (not shown). There can be more than one fastener, and accordingly there can be more than one pair of laterally aligned through holes, each configured to accommodate a fastener. In embodiments having a first end plate 360 and / or a second end plate 362, the fastener can be configured to operatively couple the first end plate 360, the inlet cassette plate 314, the outlet cassette plate 320, and the second end plate 362. The first end plate 360 can define a third axial through hole 380, and the second end plate 362 can define a fourth axial through hole 382. Each of the first, second, third, and fourth axial through holes can be configured to be laterally aligned with one another to accommodate the fastener.

[0100] Aspect 1. A cassette assembly comprising: an inlet cassette plate defining an inlet cassette inlet flow path and an inlet cassette outlet flow path, wherein the inlet cassette inlet flow path and the inlet cassette outlet flow path extend axially through the inlet cassette plate; an outlet cassette plate configured to be arranged in a stacked arrangement with the inlet cassette plate, the outlet cassette plate defining an outlet cassette inlet flow path and an outlet cassette outlet flow path, wherein the outlet cassette inlet flow path and the outlet cassette outlet flow path extend axially through the outlet cassette plate, the inlet cassette inlet flow path is configured to be laterally aligned with the outlet cassette inlet flow path, and the inlet cassette outlet flow path is configured to be laterally aligned with the outlet cassette outlet flow path; an inlet plug configured to be inserted into the outlet cassette inlet flow path to seal the outlet cassette inlet flow path, wherein the inlet plug is configured to be removable and re-insertable into the outlet cassette inlet flow path; an outlet plug configured to be inserted into the inlet cassette outlet flow path to seal the inlet cassette outlet flow path, wherein the outlet plug is configured to be removable and re-insertable into the inlet cassette outlet flow path; and a separation layer disposed between the inlet cartridge plate and the outlet cartridge plate, wherein the inlet cartridge inlet flow path is configured to be in fluid communication with the outlet cartridge outlet flow path through the separation layer to form an assembly flow path.

[0101] Aspect 2. The cartridge assembly of any of aspects 1 and 3-22, wherein the inlet cartridge plate, the outlet cartridge plate, the inlet plug, the outlet plug, and the separation layer define a single cartridge.

[0102] Aspect 3. The cartridge assembly of any of aspects 1-2 and 4-22, wherein the inlet cartridge plate, the outlet cartridge plate, the inlet plug, the outlet plug, and the separation layer define more than one cartridge.

[0103] Aspect 4. The cartridge assembly of any of aspects 1-3 and 5-22, further comprising: an inlet channel extending along an effective inlet surface area of the separation layer in fluid communication with the inlet cartridge inlet flow path; and an outlet channel extending along an effective outlet surface area of the separation layer toward the outlet cartridge outlet flow path.

[0104] Aspect 5. The cartridge assembly of any of aspects 1-4 and 6-22, further comprising: an inlet flow path extension defined by the inlet cartridge plate configured to fluidly couple the inlet cartridge inlet flow path and the inlet channel; and an outlet flow path extension defined by the outlet cartridge plate configured to fluidly couple the outlet cartridge outlet flow path and the outlet channel.

[0105] Aspect 6. The cartridge assembly of any of aspects 1-5 and 7-22, wherein the inlet flow path extension comprises: an inlet extension first portion extending laterally from the inlet cartridge inlet flow path toward the inlet channel; and an inlet extension second portion extending laterally along a width of the effective inlet surface area.

[0106] Aspect 7. The cartridge assembly of any of aspects 1-6 and 8-22, wherein the outlet flow path extension comprises: an outlet extension first portion extending laterally from the outlet cartridge outlet flow path toward the outlet channel; and an outlet extension second portion extending laterally along a width of the effective outlet surface area.

[0107] Aspect 8. The cartridge assembly of any of aspects 1-7 and 9-22, further comprising a separation layer seal mounted between the inlet cartridge plate and the outlet cartridge plate, wherein the separation layer seal is in contact with the inlet cartridge plate and the outlet cartridge plate, and wherein the separation layer seal is configured to fluidically seal a perimeter region of the separation layer, a perimeter region of the inlet channel, and a perimeter region of the outlet channel.

[0108] Aspect 9. The cartridge assembly of any of aspects 1-8 and 10-22, wherein the separation layer seal comprises an overmolded grommet.

[0109] Aspect 10. The cartridge assembly of any of aspects 1-9 and 11-22, wherein: the inlet cartridge plate defines a first port in selective fluid communication with the inlet cartridge inlet flow path, wherein the first port extends laterally through an axial surface of the inlet cartridge plate, and wherein the outlet cartridge plate defines a second port in selective fluid communication with the outlet cartridge outlet flow path, wherein the second port extends laterally through an axial surface of the outlet cartridge plate, and wherein the cartridge assembly further comprises a first port plug configured to seal the first port, wherein the first port plug is removable and reinsertable into the first port, and wherein the cartridge assembly further comprises a second port plug configured to seal the second port, wherein the second port plug is removable and reinsertable into the second port.

[0110] Aspect 11. The cartridge assembly of any of aspects 1-10 and 12-22, wherein the separation layer comprises a film stack, the film stack further comprising a plurality of film layers, and wherein the plurality of film layers comprises at least 10 film layers.

[0111] Aspect 12. The cartridge assembly of any of aspects 1-11 and 13-22, wherein the separation layer has an effective inlet surface area defined by an effective length and an effective width, and wherein the effective length is at least 2.5 times the effective width.

[0112] Aspect 13. The cartridge assembly of any of aspects 1-12 and 14-22, further comprising: an outlet channel spacer in the outlet channel, wherein the outlet channel spacer is configured to accommodate a fluid flow.

[0113] Aspect 14. The cartridge assembly of any of aspects 1-13 and 15-22, further comprising: an inlet channel spacer in the inlet channel, wherein the inlet channel spacer is configured to accommodate a fluid flow.

[0114] Aspect 15. The cartridge assembly of any of aspects 1-14 and 16-22, wherein at least one of the inlet channel spacer and the outlet channel spacer comprises a transverse ridge extending across the separation layer.

[0115] Aspect 16. The cartridge assembly of any of aspects 1-15 and 17-22, wherein the outlet cartridge plate comprises an alignment feature and the inlet cartridge plate comprises a mating alignment feature, and wherein the alignment feature and the mating alignment feature are transversely aligned to operatively couple the outlet cartridge plate and the inlet cartridge plate.

[0116] Aspect 17. The cartridge assembly of any of aspects 1-16 and 18-22, further comprising: a first end plate operatively coupled to the inlet cartridge plate; and a second end plate operatively coupled to the outlet cartridge plate, wherein the first end plate comprises a first inlet port configured to extend into the inlet cartridge inlet flow path, and wherein the second end plate comprises a second outlet port configured for fluid communication with the outlet cartridge outlet flow path.

[0117] Aspect 18. The cartridge assembly of any of aspects 1-17 and 19-22, further comprising a fastener configured to operatively couple the inlet cartridge plate and the outlet cartridge plate.

[0118] Aspect 19. The cartridge assembly of any of aspects 1-18 and 20-22, further comprising a fastener configured to operatively couple the first end plate, the inlet cartridge plate, the outlet cartridge plate, and the second end plate.

[0119] Aspect 20. The cartridge assembly of any of aspects 1-19 and 21-22, wherein the fastener comprises a bolt, and wherein the inlet cartridge plate defines a first axial through-hole and the outlet cartridge plate defines a second axial through-hole, wherein the first axial through-hole and the second axial through-hole are configured to be transversely aligned to accommodate the bolt, and wherein the cartridge assembly further comprises a first nut configured to accommodate one end of the bolt and a second nut configured to accommodate an opposite end of the bolt, and wherein the first nut and the second nut are configured to exert a compressive force on the cartridge assembly.

[0120] Aspect 21. The cartridge assembly of any of aspects 1-20 and 22, wherein the first end plate defines a third axial through-hole and the second end plate defines a fourth axial through-hole, and wherein each of the first axial through-hole, the second axial through-hole, the third axial through-hole, and the fourth axial through-hole are configured to be transversely aligned to accommodate the bolt.

[0121] Aspect 22. The cartridge assembly of any of Aspects 1-21, further comprising an attachment seal between the inlet cartridge plate and the outlet cartridge plate, wherein the attachment seal extends laterally around and outside of a periphery of the separation layer.

[0122] It should be noted that the phraseology "configured to," as used in this specification and throughout the claims, describes a system, device, or other structure being structured and / or arranged to perform a particular task or adopt a particular configuration. The word "configured to" can be used interchangeably with similar wordings such as "arranged to," "fabricated to," "manufactured to," and the like.

[0123] It should be noted that the terms "have," "include," "comprise," and variations thereof are not limited to cases where the recited circumstance or element must be present. Rather, these terms are used to indicate the presence of the recited circumstance or element or to describe additional optional circumstances or elements. In addition, "a," "an," "the," and "at least one" are used interchangeably in this document to refer to one or more instances of the thing to which the terms refer. Moreover, relative terms, such as "left," "right," "front," "frontal," "forward," "rear," "rearward," "top," "bottom," "side," "upper," "lower," "over," "under," "horizontal," "vertical," and the like can be used herein to describe one element's or feature's relationship to another element(s) or feature(s) as the spatial arrangements appear in the figures, if any. Such terminology is merely used for descriptive purposes herein and is in no way limiting to the interpretation of any embodiment described herein. Additionally, terminology of orientation "horizontal," "vertical," or other relative terms can be used herein, and if so, are from the perspective shown in a particular figure. However, such terminology is used only to simplify description, and does not limit the interpretation of any embodiment described herein.

[0124] In addition, it should be understood that any reference to an element or feature of a particular embodiment being "connected to" or "coupled to" another element or feature can mean that the element or feature is either directly connected or coupled to the other element or feature or that intervening elements or features are present. Thus, a description of an element or feature as "connected to" or "coupled to" another element or feature means that the described element or feature can be either directly connected or coupled to the other element or feature or that intervening elements or features can be present.

[0125] Unless otherwise indicated, all numbers expressing feature sizes, amounts, and physical properties used in the specification and claims are to be understood as being modified in all instances by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by those skilled in the art utilizing the teachings of the present disclosure. The numerical ranges recited in this disclosure include all values from and including the lower and upper values. For ranges containing values that are less than or greater than one or both of the endpoints, the range is inclusive of that one or both endpoints.

[0126] All publications and patent applications in this specification are indicative of the level of ordinary skill in the art to which this technology pertains. All publications and patent applications herein are incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of any inconsistency between the disclosure of the present application and the disclosure of any document incorporated herein by reference, the disclosure of the present application is intended to prevail.

[0127] The foregoing description of exemplary embodiments has been presented for the purposes of illustration and description. It is not intended to be exhaustive or to limit the embodiments to the precise form disclosed. Modifications and variations are possible in light of the above teachings. Any or all features of any or all embodiments can be applied singly or in any combination. There should be no limit to possible modifications and alterations other than those explicitly stated or implied by the above disclosure, the drawings, and the appended claims; the scope of the embodiments should be determined by a fair reading of the claims and the legal equivalents thereof.

Claims

1. A box assembly, comprising: An inlet box plate that defines an inlet flow path and an outlet flow path of an inlet box, wherein the inlet flow path and the outlet flow path of the inlet box extend axially through the inlet box plate; An outlet box plate is configured to be stacked with an inlet box plate. The outlet box plate defines an outlet box inlet flow path and an outlet box outlet flow path, wherein the outlet box inlet flow path and the outlet box outlet flow path extend axially through the outlet box plate. The inlet box inlet flow path is configured to be laterally aligned with the outlet box inlet flow path, and the inlet box outlet flow path is configured to be laterally aligned with the outlet box outlet flow path. An inlet plug configured to be inserted into the outlet box inlet flow path to seal the outlet box inlet flow path, wherein the inlet plug is configured to be removable and re-insertable in the outlet box inlet flow path; An outlet plug, configured to be inserted into the inlet box outlet flow path to seal the inlet box outlet flow path, wherein the outlet plug is configured to be removable and re-insertable in the inlet box outlet flow path; as well as A separation layer is placed between the inlet box plate and the outlet box plate, wherein the inlet flow path of the inlet box is configured to be in fluid communication with the outlet flow path of the outlet box through the separation layer to form a component flow path.

2. The box assembly of claim 1, wherein the inlet box plate, the outlet box plate, the inlet plug, the outlet plug, and the separation layer define a single box.

3. The box assembly of claim 1, wherein the inlet box plate, the outlet box plate, the inlet plug, the outlet plug, and the separation layer define more than one box.

4. The box assembly according to claim 1, further comprising: An inlet channel extends along the effective inlet surface region of the separation layer and is in fluid communication with the inlet flow path of the inlet box; as well as An outlet channel extends along the effective outlet surface area of ​​the separation layer toward the outlet flow path of the outlet box.

5. The box assembly of claim 4, further comprising: An inlet flow path extension, defined by an inlet box plate, is configured to fluidly couple the inlet box inlet flow path and the inlet channel; as well as The outlet flow path extension, defined by the outlet box plate, is configured to fluidly couple the outlet box outlet flow path and the outlet channel.

6. The cartridge assembly of claim 5, wherein the inlet flow path extension comprises: The first part of the inlet extension extends laterally from the inlet flow path of the inlet box toward the inlet channel; as well as The second part of the inlet extension extends laterally along the width of the effective inlet surface area.

7. The box assembly of claim 5, wherein the outlet flow path extension comprises: The first part of the export extension extends laterally from the export flow path of the export box toward the export channel; as well as The second part of the outlet extension extends laterally along the width of the effective outlet surface area.

8. The box assembly of claim 4, further comprising a separation layer seal mounted between the inlet box plate and the outlet box plate, wherein the separation layer seal contacts the inlet box plate and the outlet box plate, and wherein the separation layer seal is configured to fluidly seal the peripheral region of the separation layer, the peripheral region of the inlet channel, and the peripheral region of the outlet channel.

9. The box assembly of claim 8, wherein the separation layer seal comprises an overmolded gasket.

10. The box assembly of claim 1, wherein: The inlet box plate defines a first port in selective fluid communication with the inlet flow path of the inlet box, wherein the first port extends laterally through the axial surface of the inlet box plate, and The outlet box plate defines a second port that is selectively fluidly connected to the outlet flow path of the outlet box, wherein the second port extends laterally through the axial surface of the outlet box plate, and The box assembly further includes a first port plug configured to seal the first port, wherein the first port plug is removable and re-insertable into the first port, and The box assembly further includes a second port plug configured to seal the second port, wherein the second port plug is removable and re-insertable into the second port.

11. The cartridge assembly of claim 1, wherein the separation layer comprises a membrane stack, the membrane stack further comprising a plurality of membrane layers, and wherein the plurality of membrane layers comprises at least 10 membrane layers.

12. The box assembly according to claim 1, The separation layer has an effective inlet surface area defined by an effective length and an effective width, wherein the effective length is at least 2.5 times the effective width.

13. The box assembly of claim 1, further comprising: An outlet channel spacer, located in the outlet channel, wherein the outlet channel spacer is configured to accommodate fluid flow.

14. The box assembly of claim 1, further comprising: An inlet channel spacer, located in the inlet channel, wherein the inlet channel spacer is configured to accommodate fluid flow.

15. The box assembly of claim 14, wherein the inlet channel spacer includes a transverse ridge extending across the separation layer.

16. The box assembly of claim 1, wherein the outlet box plate includes an alignment feature and the inlet box plate includes a mating alignment feature, and wherein the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box plate and the inlet box plate.

17. The box assembly of claim 1, further comprising: A first end plate, which is operatively coupled to an inlet box plate; as well as The second end plate, which is operatively coupled to the outlet box plate, The first endplate includes a first inlet port configured to extend into the inlet flow path of the inlet box, and The second endplate includes a second outlet port configured for fluid communication with the outlet flow path of the outlet box.

18. The cassette assembly of claim 1, further comprising fasteners configured to operatively couple the inlet cassette plate and the outlet cassette plate.

19. The box assembly of claim 18, wherein the fastener comprises a bolt, and The inlet box plate defines a first axial through hole, and the outlet box plate defines a second axial through hole, wherein the first and second axial through holes are configured to be laterally aligned to accommodate bolts. The box assembly further includes a first nut configured to receive one end of a bolt and a second nut configured to receive the opposite end of the bolt, wherein the first nut and the second nut are configured to apply a compressive force to the box assembly.

20. The box assembly of claim 1, further comprising an attachment seal between the inlet box panel and the outlet box panel, wherein the attachment seal extends laterally around and outside the periphery of the separation layer.

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