Pharmaceutical composition for delaying senescence and resisting oxidation

Abstract

The invention discloses a pharmaceutical composition for delaying senescence and resisting oxidation, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, vitamin complex B, vitamin C, vitamin D, vitamin E, vitamin k, macroelements including calcium, phosphorus, potassium and magnesium, microelements including zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines including ginseng, astragalus membranaceus, schisandra chinensis and radix polygoni multiflori preparata, and condition essential nutrient nucleic acid. The bioactive components comprise lycopene, tea polyphenol, taurine, lutein, lutein fat, zeaxanthin, chlorophyll and the like; is mainly suitable for middle-aged and elderly people; the composition eliminates multiple factors causing aging from multiple systems, multiple links and multiple targets, can significantly delay aging, has health-care and tonifying effects such as oxidation resistance, and can improve the life quality of middle-aged and elderly people while delaying aging; the composition has no incompatibility, and does not generate any toxic or side effect after being taken for a long time.

Description

[0001] Technical Field: This invention relates to the fields of biomedicine and health food technology; in particular, pharmaceutical compositions for delaying aging and having antioxidant properties.

[0002] Background Technology: Aging is a physiological phenomenon in which the functions of various organs in the human body gradually decline. It is a slow and gradual process, an inevitable natural law. There are many theories about the causes of human aging, but they all boil down to the aging of cells and tissues. As the basic building blocks of the human body, cells cannot meet their needs for growth and metabolism if they do not receive sufficient nutrition (water, oxygen, and various nutrients), thus leading to aging. Alternatively, aging can be caused by the cytotoxic effects of excessive free radicals, byproducts produced by cells during metabolism. Cells are attacked by oxygen free radicals, preventing them from developing according to normal patterns. Long-term accumulation leads to premature aging of cells and even the entire body. Theories about aging are mainly divided into two categories: one is the natural law theory, which holds that human lifespan is determined by genetic factors and that people gradually age until death; the other is the body damage theory. The belief that the body won't age unless it suffers various forms of damage, that cellular aging isn't a natural mutation, and that declining physiological functions and degeneration of important molecules in the body lead to aging due to impaired function, all depend on external damage. Preventing this damage could potentially prevent aging, or at least delay it. Aging is a process of degeneration of the entire human body system; it doesn't just happen in old age, but is a phenomenon that accompanies life throughout its growth. Aging is passive, while delaying aging is active. Through various supportive measures, including providing necessary nutrients, clean air and water, a good living and psychological environment, and a strong sense of self-care, aging can be slowed down. The aging process is accompanied by various diseases; how can we effectively prevent these diseases and slow down the aging rate? Antioxidants are the best slowing agents.

[0003] This composition includes vitamin A, beta-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; Chinese medicinal herbs such as ginseng, astragalus, he shou wu, and schisandra; conditionally essential nutrients such as nucleic acids; and bioactive components such as tea polyphenols, lycopene, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid.

[0004] Vitamin A, also known as retinol, can improve vision and prevent night blindness and cataracts. A deficiency in vitamin A can cause corneal epithelial shedding, thickening, and keratinization, making the cornea opaque and leading to decreased and blurred vision. When vitamin A is sufficient, corneal smoothness increases, and vision improves. Vitamin A enhances immune function by regulating cellular and humoral immunity; therefore, it is also known as the "anti-infection" vitamin. Vitamin A also has antioxidant properties, inhibits tumor growth, enhances the body's resistance, promotes mucopolysaccharide synthesis, and influences bone tissue renewal and development, causing long bones to grow towards both ends. Beta-carotene can be converted into vitamin A in the body through the action of enzymes, thus fulfilling the functions of vitamin A.

[0005] B vitamins participate in the metabolism of proteins, fats, and carbohydrates in the body, working synergistically to perform physiological functions. Deficiency can lead to decreased metabolic function and various diseases. B vitamins include vitamin B1, vitamin B2, niacinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12Vitamins B1, also known as the anti-beriberi factor and anti-neuritis factor, are essential nutrients for life. Vitamin B1 deficiency is known as beriberi, clinically classified into adult beriberi and infant beriberi based on age. Early symptoms of adult beriberi are milder, mainly including fatigue, apathy, poor appetite, nausea, depression, irritability, sadness, heaviness and numbness in the legs, and abnormal electrocardiogram. Severe cases can lead to neuritis and / or heart failure and edema, potentially resulting in sudden death. Vitamin B2, also known as riboflavin, is a component of many important coenzymes in the body, participating in redox reactions in metabolism and playing a vital role in maintaining life. Vitamin B2 deficiency or insufficiency can cause angular cheilitis, glossitis, and cheilitis. Vitamin B2 deficiency is often accompanied by deficiencies in other nutrients, such as affecting niacin and vitamin B6 metabolism, interfering with the absorption, storage, and mobilization of iron in the body, leading to a decrease in stored iron and, in severe cases, iron-deficiency anemia. Nicotinamide, also known as anti-pellagra factor, has the physiological functions of participating in the metabolism of substances and energy in the body, maintaining normal nervous system function, ensuring the synthesis of sex hormones, etc., being related to nucleic acid synthesis, lowering blood cholesterol levels, and being a component of glucose tolerance factor. When deficient, pellagra can occur, with typical symptoms being dermatitis, diarrhea, and dementia. This disease often coexists with beriberi, riboflavin deficiency, and other nutrient deficiency diseases. Pantothenic acid, also known as pantothenic acid, primarily functions as a component of coenzyme A and acyl carrier proteins, playing a role in metabolism. It is widely present in every organism and participates in a wide range of metabolic activities. More than 70 enzymes are known to require pantothenic acid to catalyze various biochemical reactions in the body; otherwise, metabolic disorders will occur. Pantothenic acid deficiency is often accompanied by insufficient intake of the three macronutrients and other vitamins, leading to impaired metabolism. When experiencing unexpected emotional shocks, the body and mind undergo a series of changes, such as increased heart rate, elevated blood pressure, rapid breathing, muscle tension, and elevated blood sugar—a stress response. This stress response involves significant energy expenditure, and pantothenic acid can reduce energy consumption during stress responses; therefore, it is also known as an anti-stress vitamin. Biotin, also known as vitamin B7, works in coordination with other B vitamins to participate in the body's metabolism of substances and energy. Biotin is a coenzyme for many carboxylases in the body, playing an important role in the metabolism of carbohydrates, lipids, proteins, and nucleic acids. It participates in the metabolism of vitamin B12, folic acid, and pantothenic acid; promotes protein synthesis, urea synthesis and excretion; and participates in the synthesis of pancreatic amylase and other digestive enzymes, thus biotin is closely related to the digestive process. It is closely related to nucleic acid synthesis and sex hormone synthesis; deficiency can lead to reproductive dysfunction. Choline is also a B vitamin. In the body, it acts as a precursor to acetylcholine, improving cognitive decline; helping the liver process fat, preventing fatty liver; promoting lipoprotein synthesis; regulating cholesterol levels; maintaining cell membrane structural integrity; and supporting key physiological processes such as DNA methylation.Vitamin B6 acts as a coenzyme for transaminases and amino acid decarboxylases in the body, ensuring the metabolism of amino acids, glycogen, fatty acids, one-carbon units, niacin, and other substances; ensuring the normal metabolic processes of neurotransmitters such as serotonin, taurine, and dopamine; ensuring the synthesis of nucleic acids and proteins and the normal proliferation of cells; and ensuring normal immune function. Deficiency can cause damage to the nervous system. Vitamin B6. 12 Folic acid participates in the synthesis of nucleic acids, choline, and amino acids, as well as the metabolism of fats and sugars. It plays a role in the integrity of bone marrow hematopoiesis, digestive tract epithelial cell function, liver function, and the myelin sheath function of the nervous system. It is an essential vitamin for normal intelligence; deficiency can cause intellectual impairment and nutritional anemia, affecting blood supply to the brain. Folic acid participates in the synthesis of amino acids and nucleic acids and works with vitamin B1. 12 These substances work together to promote cell generation and maturation. A deficiency can prevent normal cells from undergoing mitosis, leading to neurological symptoms such as memory loss, depression, and dementia. Folic acid, vitamin B6, and vitamin B12 are also essential. 12 It can synergistically eliminate homocysteine ​​in the human body, a neurotoxin that can cause brain self-destruction.

[0006] Vitamin C, also known as ascorbic acid, is a highly bioactive substance with multiple physiological functions in the body: It is an important free radical scavenger, playing an anti-aging role; it is closely related to collagen, not only softening blood vessels but also purifying the blood and preventing arteriosclerosis; it promotes the absorption of iron and calcium from food; it can reduce folic acid to bioactive tetrahydrofolate, preventing megaloblastic anemia; it participates in the synthesis of neurotransmitters, and a deficiency hinders neurotransmitter formation; it promotes antibody formation, increasing the body's resistance; large doses of vitamin C can alleviate the toxicity of toxic substances such as mercury, lead, arsenic, benzene, and certain drugs and bacterial toxins; vitamin C deficiency or insufficiency can cause subcutaneous bleeding, swollen, bleeding, and ulcerated gums; long-term vitamin C deficiency increases susceptibility to viral colds.

[0007] Vitamin D derivatives refer to a large class of substances containing a cyclopentanenylphenanthrene ring structure and possessing calciferol biological activity, with vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) being the most common. Vitamin D participates in maintaining intracellular and extracellular calcium concentrations and regulating calcium and phosphorus metabolism. Maternal deficiency of vitamin D and calcium can cause bone and teeth development disorders and rickets in offspring. In adults, especially pregnant women, lactating mothers, and the elderly, vitamin D deficiency can lead to demineralization of mature bones, resulting in osteoporosis and osteomalacia.

[0008] Vitamin E is a general term for all chromone derivatives with α-tocopherol biological activity. Among them, α-tocopherol has the highest activity and can eliminate free radicals, delay aging, and prevent macrocytic hemolytic anemia. Vitamin E deficiency or insufficiency can damage the reproductive system and cause irreversible changes in the reproductive epithelium. In men, vitamin E deficiency can lead to testicular atrophy and epithelial cell degeneration.

[0009] Vitamin K is a fat-soluble vitamin that is mainly stored in the liver. Its main physiological functions are: 1. Regulating the synthesis of clotting proteins to ensure the synthesis of prothrombin and other clotting factors in the liver and ensure the operation of the clotting mechanism; 2. Ensuring the health of bone tissue, as the synthesis of three proteins in osteoblasts depends on the participation of vitamin K.

[0010] Calcium is an important macro-element in the human body, playing two main roles: first, it forms hard tissues such as bones and teeth; second, it combines with proteins or forms calcium ions to form substances with specific functions, creating a so-called miscible calcium pool, which maintains a dynamic balance with the calcium in bones and teeth. All cells in the body need calcium to perform their normal functions; calcium deficiency can cause endocrine disorders and malfunction of cell growth regulation.

[0011] Phosphorus is one of the most abundant mineral elements in the human body. An adult's body contains about 600-900g of phosphorus, which accounts for about 1% of body weight. Phosphorus is an important element in the body. It is a component of cell membranes and nucleic acids, and an essential building block of bones and teeth.

[0012] Potassium participates in cellular metabolism and provides suitable conditions for the normal activity of certain enzymes. Its prominent role is to maintain the normal excitability, automaticity, and conductivity of myocardial cells. It also plays an important role in regulating acid-base balance, maintaining osmotic pressure, and maintaining fluid balance. Both hypokalemia and hyperkalemia can cause serious damage to the human body. Mild cases may lead to fatigue and irritability, while severe cases may cause arrhythmia or even death.

[0013] The most important function of magnesium in the human body is to inhibit the production of free radicals, which are the main factors that promote aging. Another function of magnesium is to work with calcium and vitamin D to protect bones. Magnesium deficiency can easily lead to osteoporosis and fractures. In addition, magnesium also has the functions of protecting the heart and preventing diabetes.

[0014] The trace element zinc is fused into biological macromolecular ligands—proteins, nucleic acids, and membranes (mainly membrane proteins)—forming stable metal-containing biological macromolecular complexes—metallothioneins, metallonucleic acid complexes, etc. These substances are known to participate in the synthesis and degradation of carbohydrates, lipids, proteins, and nucleic acids. Zinc-containing enzymes are present in all six major classes of enzymes. Zinc is also a key element for enhancing immune activity. Zinc can promote the conversion of proinsulin to insulin by activating carboxypeptidase B; zinc deficiency inhibits insulin activity in peripheral tissues, leading to abnormal glucose tolerance curves. Recent studies have shown that zinc deficiency can cause impaired nucleic acid and protein synthesis, induce chromosomal aberrations, and enhance the sensitivity of the optic nerve. Zinc is a component of retinol reductase in retinal cells; deficiency directly affects the synthesis and metabolism of retinin by vitamin A, impairing the function of retinal and thus weakening the ability to adapt to low light. Zinc deficiency also affects the color perception of cone cells in the retina.

[0015] Selenium, a trace element, is essential for human embryonic development. It has strong antioxidant properties, protecting the embryo from damage caused by superoxide. Selenium can alleviate or reduce the toxicity caused by mercury, cadmium, lead, arsenic, thallium, nickel, sulfur, etc., and promote the excretion of toxic metals from the body. However, environmental pollution has led to an increasing exposure to these toxic elements year by year, and selenium deficiency can easily lead to Keshan disease. Selenium deficiency can also lead to reduced insulin secretion, decreased glucose tolerance, and decreased antioxidant capacity, thus accelerating human aging and cognitive decline. Selenium is an important trace element for maintaining vision, and selenium deficiency can cause amblyopia.

[0016] The main physiological function of the trace element iron is to participate in the transport of oxygen and tissue respiration in the body as a component of hemoglobin, myoglobin, cytochromes, etc.; it plays a core role in the transport of oxygen and electrons; the structure of catalase contains iron, and hydrogen peroxide is degraded by catalase. Hydrogen peroxide is the most dangerous free radical in the human body; iron deficiency can lead to iron deficiency anemia, the main symptoms of which are physical weakness, weakened memory, and decreased work capacity.

[0017] Chromium is an essential trace element. Only trivalent chromium can be used as a chromium supplement. It can enhance and promote the physiological function of insulin, prevent arteriosclerosis, enhance immune function, and promote growth and development. Chromium deficiency can lead to growth retardation and accelerated aging. Chromium deficiency in the mother can lead to chromium deficiency anemia in the offspring. Timely chromium supplementation can gradually improve the condition.

[0018] Copper mainly functions in the human body in the form of copper-containing metalloenzymes, participating in a series of metabolic functions such as iron utilization, hematopoiesis, phospholipid synthesis, and collagen connective tissue formation.

[0019] Molybdenum is one of the essential trace elements for the human body. It is a constituent element of many enzymes, participates in the utilization of iron, promotes the development and maturation of red blood cells, can prevent anemia, and helps in the metabolism of carbohydrates and fats. It participates in detoxifying the body from toxic aldehydes, eliminating free radicals, and has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions. It can be used to prevent birth defects caused by maternal molybdenum deficiency aggravated by selenium deficiency. Molybdenum has a resistant effect to mercury toxicity, can prevent lead poisoning, and has a synergistic effect with selenium. Molybdenum deficiency can also induce cardiovascular diseases, cancer, and tooth decay.

[0020] Iodine plays a major role in the synthesis of thyroid hormones in the human body. The physiological functions of thyroid hormones include regulating the body's metabolic level, affecting the body's heat production, blood sugar and ketone body levels, muscle and nerve tension, weight, intelligence and sexual function, among other things.

[0021] Fluorine is also an essential trace element for the human body. A normal human body contains approximately 2.6g of fluorine, mainly found in bones and teeth. Appropriate amounts of fluorine are beneficial for the utilization of calcium and phosphorus, promoting bone formation and strengthening bone, and accelerating bone growth. Fluorine can react with hydroxyapatite in tooth enamel to form a hard, acid-resistant protective layer of fluorapatite crystals on the tooth surface, inhibiting glycolysis and reducing the formation of acidic substances, thus preventing tooth decay. However, excessive fluorine intake can cause poisoning.

[0022] Manganese participates in the formation of some enzymes in the human body. It not only participates in the metabolism of sugars and lipids, but also plays a role in the synthesis of proteins, DNA, and RVA. Manganese is an essential trace element for maintaining human sexual function. When men are deficient in manganese, their reproductive function will be impaired, leading to testicular degeneration, reduced sperm count, degenerative changes in seminiferous tubules, and even loss of sexual ability. It can also cause decreased libido, menstrual cycle disorders, and infertility.

[0023] Ginseng is a natural Chinese medicinal herb that can be used in health foods to replenish qi. It has the effects of greatly replenishing vital energy, invigorating the spleen and lungs, promoting body fluid production and quenching thirst, calming the mind and enhancing intelligence. Clinically, it is used for symptoms such as qi deficiency and impending collapse, weak pulse and impending collapse, spleen qi deficiency, lung qi deficiency, thirst due to qi and body fluid depletion, diabetes, deficiency of both qi and blood, and malnourishment of the mind. Modern pharmacological studies have confirmed that: 1. Ginseng enhances both central nervous system excitation and inhibition; 2. Improves cognitive function; 3. Strengthens the heart, resists myocardial ischemia, dilates blood vessels, and has anti-shock effects; 4. Affects the blood and hematopoietic system, improves various blood rheological parameters, increases blood fluidity, inhibits platelet and erythrocyte aggregation, and ginseng extract can promote bone marrow hematopoietic function, significantly increasing the number of erythrocytes, leukocytes, hemoglobin, and nucleated cells in the bone marrow, and promoting the synthesis of RNA, DNA, and proteins in bone marrow cells; 5. Excites the hypothalamic-pituitary-adrenal axis; 6. Excites the hypothalamic-pituitary-sexual axis; 7. Enhances and bidirectionally regulates cyclic nucleotides; 8. Promotes and regulates immune function; 9. Regulates glucose metabolism; 10. Regulates lipid metabolism; 11. Promotes the synthesis of proteins and DNA. RNA biosynthesis increases cytoplasmic ribosomes, improves serum protein synthesis rate, and increases albumin and globulin content; 12. Delaying aging: Ginseng has the effect of delaying aging and preventing premature aging. Ginsenosides can significantly prolong animal lifespan and cell lifespan, inhibit MAO=B activity in the brainstem of aged animals, reduce the content of lipofuscin in the myocardium, brain, and liver tissues of aged rats and the content of serum lipid peroxides, increase the activity of superoxide dismutase (SOD), scavenge excess free radicals in the body, and protect biological membranes from free radical damage; In addition, human... Ginseng also brings the level of norepinephrine in the cerebral cortex of older animals close to that of younger animals; 13. Anti-stress effect: Ginseng can improve the body's non-specific resistance to adverse stimuli (such as various harmful stimuli such as physical, chemical, and biological stimuli), and has an "adaptogenic" effect. For example, ginseng has obvious anti-hypoxia, anti-high temperature, anti-low temperature, anti-fatigue and anti-radiation effects, thus reducing the damage to the body in the stress response; 14. Ginseng also has anti-tumor, liver-protecting, hemostatic, antibacterial, and skeletal muscle and smooth muscle activity regulation effects.

[0024] Astragalus is a natural Chinese medicinal herb that is both a food and a medicine, used to replenish qi. It has the effects of tonifying qi and raising yang, strengthening the defensive qi and consolidating the exterior, promoting tissue regeneration, and promoting diuresis and reducing edema. Clinically, it is used to treat spleen qi deficiency, qi failing to control blood, qi sinking, spleen and lung qi deficiency, qi and blood deficiency, qi deficiency fever, weakness and excessive sweating, qi deficiency edema, blood stasis and numbness, sequelae of stroke, and diabetes. Ancient Chinese medicine listed it as a superior herb. Modern pharmacological research has confirmed that astragalus has the following effects: 1. Enhancing the body's immunity. 1. Bidirectional regulation of the body's immune function; 2. Anti-aging function; 3. Enhancing intelligence and learning memory; 4. Anti-fatigue effect; 5. Anti-hypoxia effect; 6. Anti-radiation effect; 7. Anti-cold effect; 9. Anti-mutation effect; 10. Tumor inhibition effect; 11. Antibacterial, antiviral, and anti-inflammatory effects; 12. Liver-protecting, kidney-protecting, diuretic, and stomach-protecting effects; 13. Bone growth promoting effect; 14. Estrogen-like effect; 15. Cardiotonic, vasodilatory, and hypotensive effects; 16. Promotion of DNA, RNA, and protein synthesis; 17. Blood sugar regulation effect; 18. Prolonging the lifespan of animal cells, etc.

[0025] Schisandra chinensis is a natural Chinese medicinal herb that can be used in health foods. It has the effects of astringing the lungs and kidneys, promoting body fluid production and reducing sweating, astringing essence and stopping diarrhea, and calming the mind and soothing the nerves. It is mainly used to treat asthma due to deficiency, chronic cough, thirst due to fluid depletion, spontaneous sweating and night sweats, seminal emission, chronic diarrhea, palpitations, insomnia, and excessive dreaming. Modern pharmacological studies have confirmed that Schisandra chinensis has the following physiological functions: 1. Antioxidant effect: It has a significant protective effect against damage caused by oxygen free radicals and a significant inhibitory effect on peroxidative damage to liver, brain, heart, and kidney cell membranes and micro-lipids caused by carbon tetrachloride, etc.; 2. Anti-aging effect: Feeding 22-month-old rats with Schisandra chinensis for two months can increase SOD activity by 8.4% and decrease plasma lipid peroxides by 30.9%; 3. Liver protection effect: The alcohol extract of Schisandra chinensis kernels can be used to treat carbon tetrachloride... 4. It significantly reduces transaminase levels and protects the liver in mice with liver damage induced by thioacetamide and galactosamine; 5. It improves hypoxia tolerance, reducing myocardial oxygen consumption, increasing myocardial hypoxia tolerance, and slowing heart rate. It also significantly reduces the size of myocardial infarction; 6. It has significant effects on the central nervous system, including sedation, improved sleep, and regulation of nervous system function. It can stimulate spinal reflexes, strengthen the excitation and inhibition processes of conditioned reflexes, balance these processes, and enhance the regulatory function of the cerebral cortex, thereby improving work efficiency and producing an anti-fatigue effect; 7. It has anti-ulcer effects, antagonizing stress-induced gastric ulcers; 8. It also has antimicrobial, anti-allergic, anti-cancer, and bile secretion-promoting effects.

[0026] Prepared Polygonum multiflorum is a natural Chinese medicinal herb used in health foods to replenish blood; it has the effect of nourishing essence and blood; it is mainly used to treat deficiency of essence and blood. Modern pharmacological studies have shown that prepared Polygonum multiflorum has the following effects: 1. Anti-aging: It significantly prolongs the average survival time of elderly quails and extends their lifespan; it can also prolong the growth cycle of diploid cells in fruit flies, making cell growth vigorous and prolonging the lifespan of fruit flies; it has a significant inhibitory effect on the activity of type B monoamine oxidase in the brain and liver tissues of elderly and young mice, and can prevent the thymus of elderly mice from atrophying; it significantly counteracts the decrease in superoxide dismutase (SOD) activity in the brain, liver, blood and other tissues of aged mice, increases the content of superoxide dismutase in the tissues of aged and young mice, and significantly reduces lipofuscin in mouse cardiomyocytes, indicating that prepared Polygonum multiflorum has the following effects: Polygonum multiflorum exerts its anti-aging effects through multiple pathways; 2. It promotes hematopoietic function: processed Polygonum multiflorum can significantly increase the number of bone marrow hematopoietic stem cells, bone marrow granulocyte-monocyte progenitor cells and erythroid progenitor cells, as well as the proportion of peripheral blood reticulocytes; 3. It can increase the level of dopamine receptors in the striatum of the central nervous system of rats and improve the function of the central nervous system of aged rats; 4. It enhances immune function; 5. It significantly lowers blood lipids: it inhibits the increase of total cholesterol, triglycerides, free cholesterol and cholesterol esters in plasma, increases the ratio of high-density lipoprotein cholesterol to total cholesterol in plasma, and can significantly delay the formation and development of atherosclerosis in quail, reduce the lesion rate, and reduce the severity of aortic lesions; 6. It improves the function of the endocrine system; and protects the liver, etc.

[0027] Nucleic acids are one of the basic components of human cells. They play a dominant role in major life phenomena such as growth, development, reproduction, heredity, and variation. Their importance in biological science can be summarized by the statement, "Without nucleic acids, there is no life." When the amount of nucleic acid synthesized in the body cannot meet the needs of normal physiological functions, or when the endogenous nucleic acid synthesis capacity declines, nucleic acids become essential nutrients, hence they are currently called "conditionally essential nutrients." After entering the human body through the digestive tract, nucleic acids (products) are digested and degraded by nucleic acid hydrolysants into various nucleotide monomers, nucleosides, and bases, collectively known as nucleic acid substances, which can then be absorbed and utilized by the human body. Physiological functions: 1. Enhancing immunity and resistance to disease, increasing the number of white blood cells, cytotoxic cells, and neutrophils. 2. Delaying aging. Each cell division causes telomeres at the ends of chromosomes to be depleted. When telomeres are exhausted, cell division stops, and the cell enters the aging phase. Nucleic acids can stimulate the gonads to secrete telomerase, which synthesizes single nucleotide chains to replenish telomeres. This extends the number of cell divisions, thus delaying the aging process of cells. 3. It can regulate endocrine disorders, balancing the hypothalamus-pituitary-gonadal axis and thus alleviating various signs of aging and decline, such as the degeneration of sexual characteristics and atrophy of sexual organs, and relieving or delaying menopausal syndrome. 4. It promotes metabolism and energy supply, eliminates free radicals, mobilizes overall function, and alleviates changes in various organs and systems. 5. It has anti-radiation effects. 6. It plays a regulatory role in the absorption and utilization of the three major nutrients. For lipid metabolism, it can increase the levels of high-density lipoprotein (HDL) and polyunsaturated fatty acids in the blood, and lower cholesterol levels. In cases of low-protein diets, nucleic acid supplementation can promote protein absorption and utilization, eliminating various adverse effects caused by low-protein diets. 7. The decomposition product of RNA, nucleosides, has the effect of dilating peripheral blood vessels. Adenosine triphosphate (AMP) is the energy source for brain metabolism; therefore, many experiments have proven its significant effect on improving vascular dementia. 8. Clinically, nucleic acid preparations such as c-AMP and ATP have long been used to treat visual and hearing impairments. 9. Improves the body's tolerance to environmental changes, significantly combats fatigue, enhances the body's resistance to cold and heat, and promotes the utilization of ingested oxygen. 10. Promotes the development of the reproductive system, etc.

[0028] Lycopene is a carotenoid and a bioactive component used in health food ingredients. However, it does not have the biological activity to be converted into vitamin A in the human body. Its physiological functions include: 1. Antioxidant: Like other carotenoids, it has the ability to inhibit, scavenge, and capture free peroxide free radicals. Studies have shown that among carotenoids, lycopene has the fastest and strongest ability to scavenge oxygen free radicals, being 5.32 times that of alpha-carotene and 22.73 times that of lutein; 2. Liver protection; 3. Auxiliary tumor inhibition; 4. Lipid regulation; 5. Anti-radiation effect; 6. Anti-aging effect. Lycopene is currently the strongest antioxidant found in nature, with an effect 100 times that of vitamin E. Its ability to quench singlet oxygen and neutralize free radicals is also the strongest, and these two substances are the main causes of human aging; 7. Increased bone density: It promotes bone growth and formation, promotes osteoblast development, and prevents bone loss; 8. Promotes sperm motility, etc.

[0029] Tea polyphenols belong to the polyphenol class of bioactive components and are substances that can be used as raw materials for health foods. Their physiological functions include: 1. Delaying aging and antioxidant effects. According to animal experiments conducted by the Institute of Geriatrics, tea polyphenols can extend the average lifespan of animals by 1 / 4 to 1 / 3, and the half-life of houseflies can be extended by 13.6-15.5 days, which is 36-49% longer than the control group. Tea polyphenols have a strong antioxidant capacity and can react with excess free radicals in the body to eliminate oxygen free radicals. The maximum elimination rate reaches 98% and 99%, respectively. Its antioxidant capacity is 18 times stronger than vitamin E, and its antioxidant activity is 2.5 to 4.9 times higher than vitamin E. 2. Inhibiting cholesterol levels in the blood. 3. Inhibiting the rise in blood sugar. 4. Assisting in the inhibition of tumors. 5. Anti-fatigue effects. 6. Protecting the gastric mucosa and inhibiting the activity of Helicobacter pylori. 7. Preventing tooth decay and reducing halitosis. 8. Protecting biological macromolecules. 9. Adsorbing heavy metal ions, causing them to precipitate or be reduced.

[0030] Taurine is a non-essential amino acid and a bioactive component that can be used as a raw material in health foods. Its physiological functions include: 1. Relieving fatigue in those who are overworked, exercise excessively, or are physically exhausted; 2. Maintaining normal brain function and promoting brain development in infants and young children. Insufficient intake can slow down or affect normal brain nerve development, thus impacting intellectual development in infants and young children; 3. Maintaining normal visual function; 4. Antioxidant and anti-aging effects; 5. Enhancing immunity; 6. Lowering blood sugar, participating in insulin secretion, and protecting insulin-producing cells; 7. Participating in endocrine activities and having a series of unique effects on the cardiovascular system, strengthening left ventricular function, increasing myocardial contractility, resisting arrhythmia, preventing congestive heart failure, and lowering blood pressure; 8. Enhancing the permeability of nutrients to cells, neutralizing cytotoxins, reducing the toxicity of secondary acids, and protecting liver cell membranes, thus possessing good choleretic, hepatoprotective, and detoxifying effects; 9. Protective effect against carbon tetrachloride poisoning.

[0031] Lutein is a carotenoid bioactive component with eight isomers, predominantly all-trans, accounting for over 80%. It belongs to the same lutein class as zeaxanthin. From a physiological perspective, both cis and trans lutein have the same physiological effects, while free lutein and lutein esters also provide nutritional supplementation. After absorption, the human body can convert and metabolize lutein esters into lutein, with the ester form exhibiting better stability than the free form. Physiological functions: 1. Lutein is a major component of the macula in the eye and has a preventive effect against age-related macular degeneration. Lutein can be deposited in the lens of the eye. Lutein and zeaxanthin inhibit free radical generation by quenching singlet oxygen, thus protecting and preventing the oxidative denaturation of polyunsaturated fatty acids in retinal cells, thereby inhibiting the development of cataracts. 2. Lutein has an inhibitory effect on various cancers, such as breast cancer, prostate cancer, rectal cancer, colon cancer, and skin cancer. 3. It slows the progression of early arteriosclerosis.

[0032] Zeaxanthin, a carotenoid bioactive component, is mainly found in the endosperm of yellow-grained maize seeds, a member of the Poaceae family. Its physiological functions include: 1. As an antioxidant vitamin, anti-oxidation is its primary physiological function. 2. Protecting eyesight: Zeaxanthin, along with lutein, constitutes a major component of the macula in the eye. The macula, located in the center of the retina and lacking other carotenoids, is the most sensitive and crucial part of the visual system. Damage to the macula can severely impair vision, leading to central vision loss and ultimately blindness. Zeaxanthin, together with lutein, helps prevent age-related macular degeneration (AMD). 3. One cause of cataracts is the oxidation of proteins in the lens of the eye. Zeaxanthin can prevent damage to the eyes from singlet oxygen produced by ultraviolet radiation, preventing the oxidation of proteins and lipids in the lens and reducing the risk of age-related cataracts. 4. Reducing blood lipid oxidation, thereby slowing down arteriosclerosis. 5. Lowering the risk of cancer.

[0033] Chlorophyll is widely found in the chloroplasts of higher plants. Chlorophyll is hydrolyzed in a warm alkaline ethanol aqueous solution. After neutralization with dilute hydrochloric acid, it can be extracted with aqueous ethanol to obtain chlorophyll containing three carboxylic acid groups. Both chlorophyll and chlorophyll are bioactive components that can be used as raw materials for health food. Physiological functions: 1. Anti-mutation effect. Chlorophyll and chlorophyll have strong mutagenic effects, deactivating the activity of mutagenic substances. Chlorophyll has a strong affinity for mutagens, forming complexes that inactivate them. Chlorophyll and chlorophyll can form complexes with the carcinogen Trp-p-2, deactivating its activity, and can also inhibit the metabolic activity of mutagenic substances, promote detoxification metabolism, and control the formation of mutagenic substances. In the human body, chlorophyll can absorb the carcinogen dioxin and excrete it with feces. Dioxin has reproductive toxicity, causing reduced sperm count, decreased sexual function, decreased androgen levels, and feminized behavior in men; in women, it can cause menstrual irregularities, decreased fertility, and miscarriage. Dioxin is teratogenic to many animals. Chlorophyll also has the effect of inhibiting carcinogenic and mutagenic substances such as aflatoxin B1 and benzo[a]pyrene. 2. Protects the gastric mucosa; 3. Has anti-stress effects; 4. Promotes wound healing, etc.

[0034] The human body is a unified whole, and it carries out reproduction and physiological metabolism under the regulation of neurohumoral factors. The human body's reproduction and physiological metabolism cannot be separated from essential nutrients, and various essential nutrients need to coordinate with each other to realize the reproductive and physiological functions of the human body as a unified whole.

[0035] Existing drugs for delaying aging or providing antioxidant effects have single targets and limited efficacy. Their effects on delaying aging or providing antioxidant effects are not satisfactory.

[0036] The product contains vitamin A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 Compositions containing folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum; conditionally essential nutrients such as nucleic acids; and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid as active ingredients are known. However, compositions containing vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 as active ingredients are also known. 12There are no reports on drug compositions that combine folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, as well as traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum, conditionally essential nutrients such as nucleic acids, and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid to delay aging and have antioxidant effects.

[0037] Summary of the Invention: To overcome the shortcomings of existing anti-aging and / or antioxidant drugs, the present invention aims to provide a composition comprising ginseng, astragalus, schisandra, processed he shou wu, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid, combined with various vitamins and essential micronutrients such as minerals. The components of ginseng, astragalus, schisandra, processed he shou wu, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid can effectively promote the absorption and utilization of vitamins and minerals, increasing the levels of vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, which enhance its anti-aging and / or antioxidant effects; it also contains macroelements such as calcium, phosphorus, potassium, and magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, as well as vitamins A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, etc., and supplements and enhances the effects of ginseng, astragalus, schisandra, processed he shou wu, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid. These components enhance and regulate immunity, provide antioxidant, anti-aging, anti-mutagenic, and anti-mutagenic effects, eliminate mental and physical fatigue, improve cognitive function, promote DNA, RNA, and protein synthesis, promote hematopoiesis, regulate blood sugar and blood lipids, increase bone density, and delay aging and provide antioxidant effects. Even with long-term use, there are no side effects. Based on extensive research, the inventors have discovered that vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 are also present. 12A novel combination of folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, along with ginseng, astragalus, schisandra, processed he shou wu, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid, offers a synergistic effect in delaying aging and providing antioxidant benefits. Conversely, using vitamin A, beta-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K alone, along with macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, manganese, ginseng, astragalus, schisandra, processed he shou wu, nucleic acids, lycopene, and tea polyphenols, provides a more comprehensive and effective approach. Phenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll are all less effective than this composition. Furthermore, the active ingredients in each component have various health-promoting and nourishing effects on the human body. For example, the dosage of ginseng used in this composition has functions such as greatly replenishing vital energy, invigorating the spleen and lungs, promoting body fluid production and quenching thirst, calming the mind and enhancing intelligence, promoting protein and nucleic acid synthesis, resisting stress, and delaying aging. Astragalus has anti-aging, antioxidant, anti-mutagenic, immune-enhancing and regulating, intelligence-enhancing, and physical-strengthening effects. Schisandra has antioxidant, anti-aging, hypoxia-resistant, sedative, hypnotic, and liver-protective effects. Processed Polygonum multiflorum has functions such as replenishing essence and blood, promoting hematopoietic function, treating deficiency of essence and blood, lowering blood lipids, and anti-aging. Nucleic acid has functions such as enhancing immunity and delaying aging. It has the effects of regulating endocrine disorders, scavenging free radicals, treating visual and hearing impairments, and resisting radiation; lycopene and tea polyphenols have strong antioxidant, anti-aging, lipid-lowering, and tumor-inhibiting effects; taurine can eliminate fatigue for those who overuse their brains, exercise excessively, or work overtime, maintain normal physiological functions of the human brain, promote brain development in infants and young children, improve memory, maintain normal visual function, and has antioxidant and anti-aging effects; lutein, lutein lipids, and zeaxanthin all have the effect of scavenging free radicals and preventing macular degeneration and cataracts; chlorophyll and / or chlorophyll acid have strong mutagenic effects, anti-stress effects, wound healing aid effects, and gastric mucosa protection effects; the trace element zinc is an essential element for zinc-containing enzymes among the six major enzyme classes in the human body. Iron is a key element in the body, and also a major element in enhancing immune activity. The trace element selenium can accelerate the metabolism of excess fat in the body, has strong antioxidant functions, prevents heart disease, Keshan disease and Kashin-Beck disease, has anti-cancer functions, and alleviates or reduces the toxicity caused by teratogenic and mutagenic substances such as mercury, arsenic, lead, thallium, nickel, and sulfur. The trace element iron participates in the transport of oxygen and tissue respiration, and is a major element in preventing iron-deficiency anemia. The trace element chromium enhances and promotes the physiological function of insulin, strengthens immunity, prevents arteriosclerosis, and has anti-aging effects. The trace element copper participates in iron utilization, hematopoiesis, and phospholipid synthesis. The trace element molybdenum has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions. The trace element iodine can prevent and treat goiter caused by iodine deficiency.Trace element fluorine maintains the stability of bone and teeth structure, promotes bone formation and increases bone density, accelerates bone growth, and prevents tooth decay; trace element manganese participates in the synthesis of proteins, DNA, and RNA; vitamin A improves vision and prevents night blindness; vitamin B1 can prevent beriberi and maintain the normal physiological activities of the nervous, digestive, muscular, and circulatory systems; vitamin B2 is an essential vitamin for maintaining healthy skin and eyes; nicotinamide deficiency can cause pellagra; pantothenic acid deficiency can cause metabolic disorders; biotin can prevent gray hair and baldness; choline helps the liver process fat, prevents fatty liver, promotes lipoprotein synthesis, regulates cholesterol levels, maintains cell membrane structural integrity, and supports key physiological processes such as DNA methylation; vitamin B6 can eliminate precancerous cells, enhance immune function, and protect blood vessels; vitamin B... 12 This composition is used to prevent megaloblastic anemia and diseases of the nervous system; folic acid has cardioprotective and anti-cancer effects; vitamin C softens blood vessels, purifies blood, and prevents arteriosclerosis; vitamin E scavenges free radicals and delays aging; potassium maintains the normal excitability, automaticity, and conductivity of myocardial cells; calcium, phosphorus, magnesium, vitamin D, and vitamin K work together to ensure healthy bone tissue; this composition combines multiple antioxidant components with complementary effects, as well as functional components that enhance immunity, have antibacterial, antiviral, sedative, analgesic, cognitive-enhancing, anti-mutagenic, anti-cancer, tumor-suppressing, bone-growth-promoting, liver-protecting, kidney-protecting, and stomach-protecting effects to combat pathological aging; it also combines anti-stress components that regulate immunity, combat fatigue, resist hypoxia, resist radiation, resist high temperature, and resist cold to combat psychological aging; and it also combines functional components that promote the synthesis of human proteins, DNA, and RNA, effectively supplement telomere length, and delay physiological aging. This composition has no incompatibilities, no toxic side effects, and is low in cost, thus constituting this invention.

[0038] This invention provides a pharmaceutical composition for delaying aging and providing antioxidant effects, comprising, as active ingredients, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 Folic acid, vitamin C, vitamin D, vitamin E, vitamin K and macroelements such as calcium, phosphorus, potassium, magnesium and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, manganese, as well as ginseng, astragalus, schisandra, processed Polygonum multiflorum, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll and / or chlorophyll acid, etc.

[0039] The following vitamins are used in this invention: Vitamin B1, Vitamin B2, Nicotinamide, Pantothenic Acid, Biotin, Choline, Vitamin B6, and Vitamin B1. 12 (Vitamin B) 12Folic acid and vitamin C are water-soluble vitamins that do not accumulate in the body; vitamin A, vitamin D, vitamin E, and vitamin K are fat-soluble vitamins; beta-carotene is a precursor to vitamin A and can be converted into vitamin A in the body, and is beneficial and harmless according to the dosage used in this invention; zinc (Zn), selenium (Se), iron (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I), and fluorine (F) are essential trace elements for the human body; manganese (Mn) is a potentially essential trace element for the human body; and calcium (Ca), phosphorus (P), potassium (K), and magnesium (Mg) are essential macroelements for the human body. In this invention, the essential element calcium can be selected from calcium gluconate, calcium acetate, casein calcium, calcium chloride, calcium citrate, calcium malate, calcium citrate-malate, calcium hydrogen phosphate, calcium dihydrogen phosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate, etc.; the essential element phosphorus can be selected from calcium phosphate, calcium hydrogen phosphate, tricalcium phosphate, etc.; and the essential element potassium can be selected from potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, potassium glycerophosphate, potassium lactate, etc. For the macro-element magnesium, options include magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, and magnesium carbonate. For the trace element zinc, options include zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, and zinc monomethionine. For the trace element selenium, options include selenomethionine, selenium methoxybenzyl cyanate, sodium selenite, selenized carrageenan, cysteine ​​selenium, selenomethionine, sodium selenate, and selenium yeast. For the trace element iron, options include... Ferrous gluconate, ferrous lactate, ferric chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric pyrophosphate, ferric heme chloride, ferrous succinate, ferrous sulfate, etc. For trace element chromium, chromium trichloride, chromium nicotinate, chromium pyridinecarboxylate, chromium yeast, etc. can be used. For trace element copper, copper carbonate, copper citrate, copper gluconate, copper sulfate, etc. can be used. For trace element molybdenum, ammonium molybdate, sodium molybdate, etc. can be used. For trace element iodine, potassium iodate, etc., potassium iodate can be used. For trace element fluorine, etc., can be used. Sodium fluoride, potassium fluoride, etc. are selected; for trace element manganese, manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrate, etc. are available. Pharmaceutical raw materials for various macro-elements and trace elements, various fat-soluble vitamins and water-soluble vitamins, extracts of traditional Chinese medicines such as ginseng, astragalus, schisandra, and processed Polygonum multiflorum, nucleic acids as a conditionally essential nutrient, and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and chlorophyll are all available from professional manufacturers and suppliers.

[0040] The pharmaceutical composition of this invention is primarily suitable for middle-aged and elderly individuals; however, as a medicine for the prevention and treatment of diseases, it must comply with the drug registration management principle of "safety, effectiveness, and quality control." Due to factors such as geology, food chain, dietary habits, and duration of use, the safe, effective, and quality-controllable dosage of each component of this composition may vary among different population groups. For example, iodine supplementation is not required in high-iodine areas, selenium supplementation is not required in high-selenium areas, fluorine supplementation is not required in high-fluorine areas, molybdenum supplementation may be omitted or reduced in high-molybdenum areas or for individuals not receiving long-term parenteral nutrition, potassium or magnesium supplementation may be omitted or reduced in normal diets or for individuals not receiving long-term parenteral nutrition, and phosphorus supplementation may be omitted or reduced in normal diets or for individuals not using large doses of antacids or with renal tubular reabsorption disorders. Phosphorus: For individuals with a normal diet or those not receiving parenteral nutrition, choline may be omitted or reduced. Based on dietary and lifestyle habits and nutritional health practices, this composition aims to achieve anti-aging and antioxidant effects. The components of the traditional Chinese medicines ginseng, astragalus, wolfberry, and prepared he shou wu, the conditionally essential nutrient nucleic acid, and the bioactive components lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid can be combined as single or multiple components with various essential micronutrients such as vitamins and minerals. The pharmaceutical composition of this invention is based on suitability for the vast majority of middle-aged and elderly individuals, and is prepared as needed to improve their quality of life, delay aging, and enhance their health. According to this invention, the effective dosage of ginseng extract, calculated based on the whole natural medicinal material, is 200-5000 mg / day; the effective dosage of astragalus extract, calculated based on the whole natural medicinal material, is 330-9980 mg / day; the effective dosage of schisandra extract, calculated based on the whole natural medicinal material, is 330-6000 mg / day; the effective dosage of processed Polygonum multiflorum extract, calculated based on the whole natural medicinal material, is 330-18000 mg / day; the effective dosage of nucleic acid is 500-1500 mg / day; the effective dosage of lycopene is 10-70 mg / day; the effective dosage of tea polyphenols is 30-300 mg / day; the effective dosage of taurine is 30-1200 mg / day; the effective dosage of lutein is 5-20 mg / day; the effective dosage of lutein lipids is 10-40 mg / day; and the effective dosage of zeaxanthin is 10-40 mg / day. The effective dosage of chlorophyll and / or chlorophyll acid is 10-200 mg / day, vitamin B1 is 1-19 mg / day, vitamin B2 is 1-19 mg / day, nicotinamide is 6-49 mg / day, pantothenic acid is 3-19 mg / day, biotin is 0.012-0.099 mg / day, choline is 160-1490 mg / day, vitamin B6 is 1-20 mg / day, and vitamin B... 12The effective dosage is 0.0012–0.0099 mg / day; the effective dosage of folic acid is 0.3–0.99 mg / day; the effective dosage of vitamin C is 85–1000 mg / day; the effective dosage of vitamin A and / or β-carotene (in retinol equivalents) is 260–2600 μg RAE / day; the effective dosage of vitamin D is 0.008–0.02 mg / day; the effective dosage of vitamin E (in α-tocopherol equivalents) is 6–149 mg α-TE / day; and the effective dosage of vitamin K is 0.025– 0.099 mg / day. The effective dosage of macroelements calcium (calculated as elemental calcium) is 260-1200 mg / day, phosphorus (calculated as elemental phosphorus) is 160-800 mg / day, potassium (calculated as elemental potassium) is 1210-2600 mg / day, magnesium (calculated as elemental magnesium) is 130-400 mg / day, zinc (calculated as elemental zinc) is 6-36 mg / day, selenium (calculated as elemental selenium) is 0.016-0.39 mg / day, and iron (calculated as elemental iron) is 9-26 mg / day. The effective dosage of chromium (calculated as elemental chromium) is 0.016–0.148 mg / day, the effective dosage of copper (calculated as elemental copper) is 0.55–7 mg / day, the effective dosage of molybdenum (calculated as elemental molybdenum) is 0.03–0.8 mg / day, the effective dosage of iodine (calculated as elemental iodine) is 0.06–0.6 mg / day, the effective dosage of fluorine (calculated as elemental fluorine) is 0.5–3 mg / day, and the effective dosage of manganese (calculated as elemental manganese) is 2–10 mg / day.

[0041] The compositions of the present invention can be administered or taken directly in the following pharmaceutical formulations, such as oral preparations (e.g., granules, capsules, pills, tablets, dry syrups, liquid preparations), or foods such as solid foods (e.g., biscuits), prepared by mixing with other known additives, such as: carriers, disintegrants, sustained-release agents, excipients, fillers, coating agents, binders, lubricants, antioxidants, coating agents, colorants, flavoring agents, sweeteners, sucrose substitutes, nutritional fortifiers, flavoring agents, surfactants, plasticizers, pH adjusters, fresheners, suspending agents, defoamers, preservatives, thickeners, solubilizers, etc., prepared by conventional methods or added to foods as functional components or additives.

[0042] According to the present invention, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 are present. 12The product contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as microelements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese. It also contains the conditionally essential nutrient nucleic acid, Chinese medicinal herbs such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum, and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid. Each component can be prepared separately, and the preparations of each component can be mixed together or not mixed at the same time before application.

[0043] The advantages of this invention are that the composition scavenges free radicals from multiple systems, multiple links, and multiple targets, eliminates multiple factors that promote aging, and the components have a synergistic effect. It has a significant effect on delaying aging and scavenging free radicals, and also has a variety of health benefits for the user. The raw materials are readily available and the cost is low. The components in the composition have no toxic side effects and no incompatibilities.

[0044] Appendix 1 shows the LD50 of this composition (TP) against houseflies. 50 Comparison with experimental results of average lifespan Appendix Table 2 shows a comparison of the experimental results of this composition (TP) on SOD and lipofuscin in the brain of houseflies. Detailed Implementation: The present invention will be described in detail below with reference to the embodiments and comparison of the effects of the test embodiments. 。

[0045] Example 1:

[0046] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 3 packets of granules. Take one packet three times daily.

[0047] Example 2:

[0048] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 9 granular packets. Take 3 packets 3 times a day, with a 1-day interval between doses.

[0049] Example 3:

[0050] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to form 3 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 1 tablet 3 times a day.

[0051] Example 4:

[0052] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to make 4 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 2 tablets twice a day.

[0053] Example 5:

[0054] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to form 3 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 1 tablet 3 times a day.

[0055] Example 6:

[0056] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to form 2 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 1 tablet twice a day.

[0057] Example 7:

[0058] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium stearate, and flavoring agents, and the resulting mixture is then made into 3 tablets. Take one tablet three times daily.

[0059] Example 8:

[0060] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium stearate, and flavoring agents. The resulting mixture is then made into 3 packets of granules. Take one packet three times daily.

[0061] Appendix 1 shows the LD50 of this composition (TP) against housefly. 50 Comparison with experimental results of average lifespan

[0062] Appendix Table 2 shows a comparison of the experimental results of this composition (TP) on SOD and lipofuscin in the brain of houseflies.

[0063] The experimental results in Appendix Table 1 show that, compared with the control group, this composition has a greater effect on the LD50 of houseflies. 50 It has a significant effect on extending average lifespan.

[0064] The experimental results in Appendix Table 2 show that, compared with the control group, this composition significantly increases SOD in the brain of houseflies and significantly reduces lipofuscin in the brain.

Claims

1. A pharmaceutical composition for delaying aging and possessing antioxidant properties, characterized in that, It is made from the following raw materials in the following weight ratio:

2. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

3. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

4. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

5. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

6. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

7. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

8. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

9. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

10. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

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