Cell subpackaging device and multifunctional automatic precise cell subpackaging equipment

Abstract

The invention provides a cell subpackaging device and multifunctional automatic precise cell subpackaging equipment, and relates to the technical field of biomedical treatment. The cell subpackaging device comprises a subpackaging shell and an injector push-and-pull part, the injector push-and-pull part comprises a first linear driving assembly, an injector supporting plate, an injector clamping plate and a positioning assembly, the first linear driving assembly is arranged in the cavity and connected with the subpackaging shell, and the injector supporting plate is connected with the first linear driving assembly; the positioning assembly is arranged on the split charging shell and used for being matched with an injector in a positioning mode. The bottom of a piston of the injector is clamped through cooperation of the injector clamping plate and the injector supporting plate. The first linear driving assembly is adopted to drive the injector supporting plate to move so as to push and pull the piston of the injector for split charging, the amount of injection liquid can be accurately controlled, and the split charging speed can be flexibly adjusted.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of biological medical technology, and in particular to a cell sub-packaging device and a multifunctional cell automatic precision sub-packaging equipment. BACKGROUND

[0002] Cell preparation sub-packaging technology is an important part of the field of biological medical technology and is crucial to cell therapy and pharmaceutical preparation. If the requirements for stable and high-precision sub-packaging cannot be met, the therapeutic effect of cell preparations will be affected and the treatment opportunity of patients will be delayed. In the prior art, the measurement of the volume of liquid during sub-packaging is usually achieved by manually starting and stopping a peristaltic pump, weighing, and manually recording. The above-mentioned method is slow in sub-packaging speed and cannot quickly sub-packaging a large dose of cell preparation products into sub-packaging bags in a short time. The above-mentioned method is slow in sub-packaging speed and low in sub-packaging precision during the sub-packaging process. SUMMARY

[0003] The present application provides a cell sub-packaging device to solve the problem of slow sub-packaging speed and low sub-packaging precision in the prior art.

[0004] The present application provides a cell sub-packaging device, comprising: a sub-packaging shell having a cavity inside; a syringe push-pull component, comprising a first linear drive assembly, a syringe support plate, a syringe clamping plate, and a positioning assembly, the first linear drive assembly being arranged in the cavity and connected with the sub-packaging shell, the syringe support plate being connected with the first linear drive assembly, the positioning assembly being arranged in the sub-packaging shell and used for positioning cooperation with a syringe; the first linear drive assembly is used to drive the syringe support plate and the syringe clamping plate to move in a first direction; the first linear drive assembly is used to drive the syringe support plate and the syringe clamping plate to move in the first direction, so as to drive the piston rod of the syringe to move up and down in the first direction, so as to make the syringe perform liquid outflow or liquid inflow. According to the cell sub-packaging device provided by the present application, the syringe push-pull component further comprises: a second linear drive assembly, the second linear drive assembly being arranged in the syringe support plate and connected with the syringe clamping plate; the second linear drive assembly is used to drive the syringe clamping plate to move close to or away from the syringe support plate in the first direction, so as to clamp or release the bottom of the piston of the syringe.

[0005] According to the cell sub-packaging device provided by the present application, a limiting groove is arranged at the first end of the syringe clamping plate, the syringe clamping plate is connected with the push rod end of the syringe through the limiting groove, and the second end of the syringe clamping plate is connected with the second linear drive assembly.

[0006] According to a cell dispensing device provided by the present invention, a groove is provided at the second end of the syringe clamping plate, and a floating joint is provided on the telescopic shaft of the second linear drive assembly, the floating joint engaging with the groove.

[0007] According to a cell dispensing device provided by the present invention, a limiting hole is provided at the first end of the syringe tray, the syringe tray is sleeved on the syringe through the limiting hole, and the second end of the syringe tray is connected to the first linear drive assembly.

[0008] According to a cell dispensing device provided by the present invention, the first linear drive assembly includes: First linear drive component; A connecting mechanism is provided, wherein the first linear drive member is connected to the second end of the syringe tray via the connecting mechanism; A fixing plate is connected to the first linear drive component and the sub-assembly housing.

[0009] According to a cell dispensing device provided by the present invention, the syringe push-pull component further includes: The first sensor assembly includes a first position sensor and a first position sensing element, wherein the first position sensor is disposed on the first linear drive member and the first position sensing element is disposed on the connecting mechanism.

[0010] According to a cell dispensing device provided by the present invention, the syringe push-pull component further includes: The second sensor assembly includes a second position sensor and a second position sensing element. The second position sensor is disposed on the connecting mechanism, and the second position sensing element is disposed on one side of the syringe clamping plate.

[0011] According to a cell dispensing device provided by the present invention, the syringe push-pull component further includes: A guide assembly includes a guide shaft and an oil-free bushing. The guide shaft is disposed on one of the syringe support plate and the syringe clamping plate, and the oil-free bushing is disposed on the other of the syringe support plate and the syringe clamping plate. The oil-free bushing is sleeved on the outer periphery of the guide shaft and slides in a first direction with the guide shaft.

[0012] According to a cell dispensing device provided by the present invention, the cell dispensing device further includes: A positioning component is disposed in the packaging housing, and the positioning component is used to cooperate with the consumable's pallet for positioning. A plug valve clamp assembly is disposed in the sub-assembly housing, and the plug valve clamp assembly is used to drive the plug valve switching channel of the consumable.

[0013] According to a cell dispensing device provided by the present invention, the cell dispensing device further includes: A fixing component includes a rotating handle, a connecting shaft, a fixing base, and a positioning plate. The fixing base is connected to the sub-assembly housing and is hollow inside. The positioning plate is rotatably disposed inside the fixing base. One end of the connecting shaft is connected to the rotating handle, and the other end of the connecting shaft is connected to the positioning plate. The outer circumferential surface of the positioning plate is provided with a groove. The inner wall of the fixing base is provided with at least one third ball screw that positions and engages with the groove. The locking plate is provided with a locking hole, and the rotating handle locks the locking plate through the locking hole.

[0014] According to a cell dispensing device provided by the present invention, the positioning component includes a syringe positioning plate disposed on one side of the dispensing housing. The syringe positioning plate is provided with two positioning protrusions, which are arranged at intervals in the vertical direction. Each positioning protrusion is provided with a snap-fit ​​groove for snap-fitting with a syringe. A positioning groove is formed between the two positioning protrusions for snap-fitting with a syringe mounting plate.

[0015] The present invention also provides a multifunctional automated precision cell dispensing device, including the cell dispensing apparatus described in any of the above claims.

[0016] The cell dispensing device provided by the present invention clamps the bottom of the syringe piston by means of a syringe clamping plate and a syringe support plate; by using a first linear drive component to drive the syringe support plate to move, the syringe piston is pushed and pulled for dispensing, the amount of injected liquid can be precisely controlled, and the dispensing speed can be flexibly adjusted. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0018] Figure 1 This is a three-dimensional structural diagram of the multifunctional automated precision cell dispensing equipment provided by the present invention.

[0019] Figure 2 This is a three-dimensional structural diagram of the cell dispensing device provided by the present invention.

[0020] Figure 3 This is a schematic diagram of the syringe push-pull component provided by the present invention.

[0021] Figure 4 This is a schematic diagram of the structure of the plug valve clamp assembly provided by the present invention.

[0022] Figure 5 This is a three-dimensional structural diagram of the cell dispensing device and consumables provided by the present invention.

[0023] Figure 6 This is a three-dimensional structural diagram of the positioning component provided by the present invention.

[0024] Figure 7 This is a three-dimensional structural diagram of the positioning block provided by the present invention.

[0025] Figure 8 This is a three-dimensional structural diagram of the fixing component provided by the present invention.

[0026] Figure 9 This is a three-dimensional structural diagram of the positioning component provided by the present invention.

[0027] Figure 10 This is a three-dimensional structural diagram of the consumables provided by the present invention.

[0028] Figure 11 This is a three-dimensional structural diagram of the cell constant temperature shaking device provided by the present invention.

[0029] Figure 12 This is a three-dimensional structural diagram of the control device provided by the present invention.

[0030] Figure label: 1. Cell thermostatic shaking device; 11. Shaking shell; 12. Thermostatic component; 13. Shaking component; 14. Insulated opening and closing door; 15. Glass; 2. Cell dispensing device; 21. Dispensing shell; 22. Syringe push-pull component; 24. Stopcock valve clamp assembly; 25. Positioning component; 26. Fixing component; 221. Syringe support plate; 222. Syringe clamping plate; 223. Second linear drive assembly; 224. Positioning assembly; 225. Limiting groove; 226. Floating connector; 227. Limiting hole; 228. First linear drive component; 229. Connecting mechanism; 230. Fixing plate; 231. First position sensor; 232. First position sensing element; 233. Second position sensor; 234. Second position sensing element; 235. Guide shaft; 236. Oil-free bushing; 237. Positioning protrusion; 238. Positioning groove; 239. First guide slope; 240. Plug valve chuck; 241. Rotary shaft; 242. First drive mechanism; 243. First sensor; 244. Angle position sensing element; 245. 246. Second sensor; 247. Origin sensing element; 248. First ball screw; 249. Second ball screw; 250. Snap ring; 251. Positioning block; 252. Elastic buckle; 253. Elastic element; 254. Limiting element; 255. Third sensor; 256. Second guide slope; 257. Motor mounting plate; 258. Syringe positioning plate; 261. Rotating handle; 262. Connecting shaft; 263. Fixed base; 264. Positioning disk; 265. Groove; 266. Third ball screw; 270. Industrial camera; 271. Bubble sensor group; 272. Second bubble sensor; 273. Cell dispensing module alarm light; 274. Consumable installation confirmation button; 275. Cell dispensing module power button; 3. Control device; 31. Housing; 32. Display screen; 33. Movable arm; 34. Power button for control and operation module; 35. Alarm light for control and operation module; 36. Data cable interface; 220. First linear drive assembly; 4. Consumables; 41. Pallet; 42. Fluid hose; 43. Syringe mounting plate; 44. Plug valve. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0032] In the description of the embodiments of the present invention, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention. In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of the embodiments of the present invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of the present invention based on the specific circumstances.

[0034] In embodiments of the present invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0035] The following is combined with Figures 1-12 The specific structure and working principle of the syringe push-pull component of the present invention are described.

[0036] like Figure 2 and Figure 3As shown, the cell dispensing device 2 includes a dispensing housing 21 and a syringe push-pull component 22, with the dispensing housing 21 having an internal cavity. The syringe push-pull component 22 includes a first linear drive assembly 220, a syringe support plate 221, a syringe clamping plate 222, and a positioning assembly 224. The first linear drive assembly 220 is disposed in the cavity and connected to the dispensing housing 21, and the syringe support plate 221 is connected to the first linear drive assembly 220. The positioning assembly 224 is disposed in the dispensing housing 21 and is used to position and cooperate with the syringe. The first linear drive assembly 220 is used to drive the syringe support plate 221 and the syringe clamping plate 222 to move along a first direction, thereby driving the syringe piston rod to move up and down along the first direction, so that the syringe can dispense or dispense liquid.

[0037] The cell dispensing device 2 provided by the present invention clamps the bottom of the syringe piston by means of a syringe clamping plate 222 and a syringe support plate 221; by using a first linear drive component to drive the syringe support plate 221 to move, the syringe piston is pushed and pulled for dispensing, the amount of injected liquid can be precisely controlled, and the dispensing speed can be flexibly adjusted.

[0038] It should be noted that the first direction of motion refers to the up and down direction; of course, the first direction can also refer to the horizontal direction.

[0039] In one embodiment of the present invention, the syringe push-pull component 22 further includes a second linear drive assembly 223, which is disposed on the syringe support plate 221 and connected to the syringe clamping plate 222. The second linear drive assembly 223 is used to drive the syringe clamping plate 222 to move closer to or further away from the syringe support plate 221 in a first direction, so that the bottom of the syringe piston is clamped or released.

[0040] In one embodiment of the present invention, such as Figure 2 and Figure 9 As shown, the positioning assembly 224 includes a syringe positioning plate 258, which is disposed on one side of the packaging housing 21. The syringe positioning plate 258 has two positioning protrusions 237, which are spaced apart vertically. Each positioning protrusion 237 has a snap-fit ​​groove for engaging with the syringe. A positioning groove 238 is formed between the two positioning protrusions 237 for engaging with the syringe mounting plate 43. The width of the positioning groove 238 is adapted to the thickness of the syringe mounting plate 43. When installing the syringe, since the openings of the snap-fit ​​groove and the positioning groove 238 both face away from the packaging housing 21, the syringe can be easily snapped into the snap-fit ​​groove, and the syringe mounting plate 43 can be easily snapped into the positioning groove 238.

[0041] In a preferred embodiment of the present invention, a first guide slope 239 is provided on the edge of the opening of the positioning groove 238. The first guide slope 239 is inclined toward the inside of the positioning groove 238. By providing the first guide slope 239, the width of the positioning groove 238 is increased, so that the syringe mounting plate 43 can be easily locked in the positioning groove 238.

[0042] In a preferred embodiment of the present invention, the inner wall of the positioning groove 238 is provided with a mounting hole, and an elastic positioning member is provided in the mounting hole. A positioning hole is provided on one side of the syringe mounting plate 43, and the positioning hole engages with the elastic positioning member to fix the syringe to the syringe positioning plate 258. Preferably, the elastic positioning member is a first ball screw 247.

[0043] In one embodiment of the present invention, such as Figure 3 As shown, the syringe clamping plate 222 has a plate-like structure and is horizontally arranged. A vertical strip hole is provided on one side of the dispensing housing 21. The first end of the syringe clamping plate 222 extends out of the dispensing housing 21 through the vertical strip hole, and the width of the first end of the syringe clamping plate 222 is greater than the width of the second end of the syringe clamping plate 222.

[0044] The syringe clamping plate 222 has a limiting groove 225 at its first end. The limiting groove 225 is semi-circular and its size is adapted to the size of the syringe. The syringe clamping plate 222 is engaged with the end of the syringe plunger through the limiting groove 225. The second end of the syringe clamping plate 222 is connected to the second linear drive assembly 223.

[0045] In one embodiment of the present invention, since the width of the vertical strip hole is relatively large, affecting the aesthetics of the dispensing device, a baffle is provided for the vertical strip hole, and the baffle is vertically arranged. Correspondingly, a horizontal strip hole is provided in the middle of the syringe clamping plate 222, and the baffle passes through the horizontal strip hole. The baffle can both block the vertical strip hole and not affect the movement of the syringe clamping plate 222.

[0046] In one embodiment of the present invention, such as Figure 3 As shown, a slot is provided at the second end of the syringe clamping plate 222, extending along the width direction of the syringe clamping plate 222. A floating joint 226 is provided on the telescopic shaft of the second linear drive assembly 223, and the floating joint 226 engages with the slot. Preferably, there is a gap between the floating joint 226 and the slot, which facilitates the installation and disassembly of the dispensing device.

[0047] In one embodiment of the present invention, such as Figure 3As shown, the syringe support plate 221 has a plate-like structure and is horizontally arranged. The first end of the syringe support plate 221 is provided with a limiting hole 227, which is a circular through hole. The size of the limiting hole 227 is adapted to the size of the syringe. The syringe support plate 221 is sleeved on the syringe through the limiting hole 227. The second end of the syringe support plate 221 is connected to the first linear drive assembly 220.

[0048] In one embodiment of the present invention, the width of the first end of the syringe support plate 221 is greater than the width of the second end of the syringe support plate 221, and a horizontal strip-shaped through hole is provided in the middle of the syringe support plate 221, with a baffle passing through the horizontal strip-shaped through hole.

[0049] In one embodiment of the present invention, such as Figure 3 As shown, the second linear drive assembly 223 includes a second lead screw motor, which is located on the side of the syringe holder 221 opposite to the syringe clamping plate 222. The housing of the second lead screw motor is connected to the syringe holder 221 by screws. The telescopic shaft of the second lead screw motor passes through the syringe holder 221 and is connected to the floating connector 226. When the telescopic shaft of the second lead screw motor extends, the syringe clamping plate 222 moves away from the syringe holder 221; when the telescopic shaft of the second lead screw motor retracts, the syringe clamping plate 222 moves closer to the syringe holder 221. During the process of moving closer to or away from the syringe holder 221, the syringe clamping plate 222 pushes and pulls the syringe piston for dispensing. Due to the high motion precision of the lead screw motor, the amount of injected liquid can be precisely controlled, improving the dispensing accuracy.

[0050] Of course, the specific type of the second linear drive is not limited to a ball screw motor; it can also be a cylinder or other linear drive.

[0051] In one embodiment of the present invention, such as Figure 3 As shown, the first linear drive assembly 220 includes a first linear drive member 228, a connecting mechanism 229, and a fixing plate 230, all of which are located within a cavity. The fixing plate 230 provides a mounting base for the first linear drive member 228 and is connected to both the first linear drive member 228 and the sub-assembly housing 21. Specifically, a connecting plate is provided at the bottom of the fixing plate 230, and the connecting plate is connected to the sub-assembly housing 21 by screws. The first linear drive member 228 is vertically disposed on one side of the fixing plate 230 and is connected to the fixing plate 230 by screws. The first linear drive member 228 is connected to the second end of the syringe support plate 221 via the connecting mechanism 229.

[0052] Preferably, the first linear drive component 228 is a lead screw motor module, the base of which is connected to the fixing plate 230 by screws, and the slider of which is connected to the connecting mechanism 229 by screws. Of course, the specific type of the first linear drive component 228 is not limited to a lead screw motor module; it can also be a cylinder or other linear drive component.

[0053] In one embodiment of the present invention, the connecting mechanism 229 includes a mounting plate, which is connected to the slider of the lead screw motor module by screws, and the second end of the syringe support plate 221 is connected to the mounting plate by screws.

[0054] In one embodiment of the present invention, such as Figure 3 As shown, the syringe push-pull component 22 also includes a first sensor assembly, which includes a first position sensor 231 and a first position sensing plate 232. The first position sensor 231 is disposed on the first linear drive member 228, and the first position sensing plate 232 is disposed on the connecting mechanism 229. Specifically, the first position sensing plate 232 is disposed on one side of the mounting plate. When the first linear drive member 228 drives the connecting mechanism 229 to move, the connecting mechanism 229 drives the first position sensing plate 232 to move. The first position sensor 231 determines the position of the connecting mechanism 229 by detecting the position of the first position sensing plate 232, and finally calculates the positions of the syringe support plate 221, the syringe clamping plate 222, and the second linear drive assembly 223.

[0055] Preferably, the first sensor assembly includes three first position sensors 231 and two first position sensing plates 232. The three first position sensors 231 are spaced apart along the vertical direction on one side of the lead screw motor module base, and the two first position sensing plates 232 are spaced apart along the vertical direction on one side of the mounting plate.

[0056] When the lead screw motor module drives the mounting plate to move up and down, the first position sensing plate 232 moves up and down along with the mounting plate. The first position sensor 231 determines the position of the syringe holder 221 by detecting the position of the first position sensing plate.

[0057] In one embodiment of the present invention, such as Figure 3 As shown, the syringe push-pull component 22 also includes a second sensor assembly, which includes a second position sensor 233 and a second position sensing plate 234. The second position sensor 233 is disposed on the connecting mechanism 229, specifically, the second position sensor 233 is disposed on the mounting plate; the second position sensing plate 234 is disposed on one side of the syringe clamping plate 222.

[0058] When the telescopic shaft of the second lead screw motor extends, the syringe clamping plate 222 moves away from the syringe support plate 221, causing the second position sensing plate 234 to move away from the second position sensor 233; when the telescopic shaft of the second lead screw motor retracts, the syringe clamping plate 222 moves closer to the syringe support plate 221, causing the second position sensing plate 234 to move closer to the second position sensor 233 and eventually enter the sensing range of the second position sensor 233. At this time, the second position sensor 233 outputs an electrical signal, indicating that the liquid in the syringe has been discharged.

[0059] In one embodiment of the present invention, such as Figure 3 As shown, the syringe push-pull component 22 also includes a guide assembly, which includes a guide shaft 235 and an oil-free bushing 236. The guide shaft 235 is disposed in one of the syringe support plate 221 and the syringe clamping plate 222, and the guide shaft 235 is vertically disposed. The oil-free bushing 236 is disposed in the other of the syringe support plate 221 and the syringe clamping plate 222. Preferably, the other of the syringe support plate 221 and the syringe clamping plate 222 is provided with a mounting hole, and the oil-free bushing 236 is embedded in the mounting hole. The position of the oil-free bushing 236 corresponds one-to-one with the position of the guide shaft 235. The oil-free bushing 236 is sleeved on the outer periphery of the guide shaft 235 and slides with the guide shaft 235 in the first direction.

[0060] Preferably, the syringe push-pull component 22 further includes two guide components symmetrically arranged on both sides of the floating connector 226. The syringe clamping plate 222 has two connecting holes on the side facing the syringe support plate 221, and one end of each of the two guide shafts 235 is inserted into one of the two connecting holes. The syringe support plate 221 has two mounting holes on the side facing the syringe clamping plate 222, and two oil-free bushings 236 are correspondingly embedded in the two mounting holes. The other ends of each of the two guide shafts 235 are correspondingly inserted into the two oil-free bushings 236.

[0061] During the up-and-down movement of the syringe clamping plate 222 driven by the telescopic shaft of the second lead screw motor, the movement of the syringe clamping plate 222 is more stable due to the guiding cooperation between the guide shaft 235 and the oil-free bushing 236.

[0062] In one embodiment of the present invention, such as Figure 2 and Figure 3 As shown, the cell dispensing device 2 also includes a positioning component 25 and a stopcock valve clamp component. The positioning component 25 is disposed on the dispensing housing 21 and is used to position and cooperate with the clamping plate 41 of the consumable 4 so that the consumable 4 is fixed to one side of the dispensing housing 21. The stopcock valve clamp component is disposed on the dispensing housing 21. Preferably, the stopcock valve clamp component is located on one side of the dispensing housing 21 and is used to drive the stopcock valve 44 of the consumable 4 to switch channels.

[0063] In one embodiment of the present invention, such as Figure 3 As shown, the positioning component 25 includes two positioning blocks 250, which are spaced apart along the width direction of the sub-packaging housing 21. The positioning blocks 250 are connected to the sub-packaging housing 21. Preferably, the positioning blocks 250 are connected to the sub-packaging housing 21 by screws, and the positioning blocks 250 are positioned and engaged with the retaining plate 41 of the consumable 4. Specifically, the positioning blocks 250 are provided with notches, and the retaining plate 41 is engaged in the notches.

[0064] Preferably, the cell dispensing device 2 further includes two positioning components 25. One positioning component 25 is disposed on the upper part of one side of the dispensing housing 21, and the other positioning component 25 is disposed on the middle part of one side of the dispensing housing 21. The notches of the two positioning blocks 250 located at the upper part face downwards, and the notches of the two positioning blocks 250 located at the lower part face upwards. During installation, the four corners of the card plate 41 are engaged with the notches of the four positioning blocks 250 to fix the card plate 41.

[0065] In one embodiment of the present invention, such as Figure 6 As shown, the positioning component 25 also includes at least one locking assembly. The locking assembly includes an elastic buckle 251, an elastic element 252, and a limiting element 253. The limiting element 253 is disposed opposite to the elastic buckle 251 on the positioning block 250. The elastic buckle 251 is rotatably engaged with the positioning block 250 via a pin. The elastic element 252 is disposed between the elastic buckle 251 and the limiting element 253. The elastic buckle 251 is used to lock the card plate 41. The elastic element 252 can be a V-shaped spring or a torsion spring. Under the elastic action of the elastic element 252, the elastic buckle 251 abuts against the side of the card plate 41 away from the packaging housing 21, thereby preventing the consumable 4 from separating from the positioning block 250.

[0066] Preferably, one of the positioning blocks 250 in each positioning component 25 is provided with a locking component, such as... Figure 1 As shown, in the upper positioning component 25, the left positioning block 250 is equipped with a locking component, and in the lower positioning component 25, the right positioning block 250 is equipped with a locking component. This allows for locking of one diagonal of the card plate 41, effectively improving the stability of the consumable 4 after installation. Alternatively, the right positioning block 250 in the upper positioning component 25 can be equipped with a locking component, and the left positioning block 250 in the lower positioning component 25 can be equipped with a locking component.

[0067] In one embodiment of the present invention, such as Figure 7 As shown, the positioning component 25 also includes a positioning element, which is disposed on the positioning block 250. The side of the clamping plate 41 is provided with a positioning hole, and the positioning element and the positioning hole are positioned and engaged. The positioning engagement between the positioning element and the positioning hole can further improve the stability of the clamping plate 41 after it is installed in place.

[0068] Preferably, the positioning component is a second ball screw 248, and the side wall of the notch is provided with a mounting hole. The second ball screw 248 is embedded in the mounting hole, and the ball of the second ball screw 248 protrudes from the edge of the mounting hole. When the clamping plate 41 is installed in place, the ball abuts against the positioning hole to achieve positioning and engagement with the positioning hole.

[0069] Preferably, a second guide slope 256 is provided at the edge of the notch, and the second guide slope 256 is inclined inward towards the notch. When installing the clamping plate 41, the clamping plate 41 slides into the second guide slope 256, allowing the clamping plate 41 to easily enter the notch and be locked by the positioning and locking components. Through the cooperation of the second guide slope 256 with the positioning and locking components, the consumable 4 can be installed quickly, shortening the assembly time of the consumable 4 and improving the dispensing efficiency.

[0070] In one embodiment of the present invention, such as Figure 5 and Figure 6 As shown, the positioning component 25 also includes a third sensor 254, which is disposed on the positioning block 250. The third sensor 254 is used to detect whether the card plate 41 is installed in place. The third sensor 254 can be a contact switch or other sensor. When the card plate 41 is inserted into the notch, the card plate 41 contacts the third sensor 254, triggering the third sensor 254 to output an electrical signal, indicating that the card plate 41 is installed in place.

[0071] In one embodiment of the present invention, such as Figure 8 As shown, the cell dispensing device 2 also includes a fixing component 26, which includes a rotating handle 261, a connecting shaft 262, a fixing base 263, and a positioning disk 264. The fixing base 263 is connected to the dispensing housing 21, and the interior of the fixing base 263 is hollow. The positioning disk 264 is rotatably disposed inside the fixing base 263. One end of the connecting shaft 262 is connected to the rotating handle 261, and the other end of the connecting shaft 262 is connected to the positioning disk 264.

[0072] The outer peripheral surface of the positioning disk 264 is provided with grooves 265, which extend along the central axis of the positioning disk 264. In this embodiment, four grooves 265 are provided, and the four grooves 265 are arranged symmetrically in pairs. Preferably, two first grooves 265 are located in a first plane, and the other two first grooves 265 are located in a second plane, with the first plane perpendicular to the second plane. Of course, the number of grooves 265 is not limited to four; six, eight, or more can also be provided. The inner wall of the fixing base 263 is provided with two third ball screws 266, which are arranged symmetrically.

[0073] The card plate 41 is provided with locking holes, the positions of which correspond one-to-one with the positions of the rotating handles 261. The shapes of the locking holes are adapted to the shapes of the rotating handles 261, and the rotating handles 261 lock the card plate 41 through the locking holes. The rotating handles 261 are suitable for switching between an open state and a locked state. In the open state, the rotating handles 261 are in a vertical position, and the third ball screw 266 in the fixing base 263 is positioned and engaged with the groove 265 to keep the rotating handles 261 in the open state. In the open state, the rotating handles 261 can pass through the locking holes of the card plate 41. When the rotating handles 261 are rotated 90°, the rotating handles 261 are in the locked state. In the locked state, the rotating handles 261 are in a horizontal position, and the third ball screw 266 in the fixing base 263 is positioned and engaged with the groove 265 to keep the rotating handles 261 in the locked state; at this time, the rotating handles 261 cannot pass through the locking holes of the card plate 41, thus achieving the locking of the card plate 41.

[0074] In one embodiment of the present invention, the cell dispensing device 2 further includes a second circuit board disposed inside the dispensing housing 21, and the second circuit board is electrically connected to the third sensor 254. The second circuit board is electrically connected to a corresponding interface via wires.

[0075] In one embodiment of the present invention, Figure 2 As shown, the plug valve chuck assembly includes multiple plug valve chuck assemblies 24, which are disposed in the sub-assembly housing 21 and spaced apart along the width direction of the sub-assembly housing 21. The distance between two adjacent plug valve chuck assemblies 24 is equal. The plug valve chuck assemblies 24 are used to drive the plug valves 44 of the consumable 4 to switch channels. The number of plug valve chuck assemblies 24 is the same as the number of plug valves 44, and the positions of the plug valve chuck assemblies 24 correspond one-to-one with the positions of the plug valves 44.

[0076] In one embodiment of the present invention, such as Figure 2 and Figure 4 As shown, the plug valve chuck assembly 24 includes a plug valve chuck 240, a rotating shaft 241, and a first drive mechanism 242. The plug valve chuck 240 is located outside the sub-assembly housing 21 and is used to clamp and rotate the plug valve 44. A plug valve positioning groove is provided at the end of the plug valve chuck 240, which engages with the plug valve 44. The shape of the plug valve positioning groove matches the shape of the plug valve 44; in this embodiment, the cross-section of the plug valve positioning groove is T-shaped. However, the cross-sectional shape of the plug valve positioning groove is not limited to this and is determined based on the shape of the plug valve 44. By using the plug valve chuck 240 to engage with the plug valve 44, the installation of consumable 4 can be facilitated.

[0077] The rotating shaft 241 is horizontally positioned and is used to connect the first drive mechanism 242 and the plug valve 44. The sub-housing 21 has mounting holes, through which the first end of the rotating shaft 241 passes and connects to the plug valve chuck 240. The rotating shaft 241 and the plug valve chuck 240 can be welded together, integrally formed, or threaded together. Preferably, the rotating shaft 241 and the plug valve chuck 240 are integrally formed.

[0078] The first drive mechanism 242 is connected to the sub-containment housing 21 via a motor mounting plate 257. Specifically, the first drive mechanism 242 is connected to the motor mounting plate 257 via screws, and the motor mounting plate 257 is connected to the side wall of the sub-containment housing 21 via screws.

[0079] The rotating shaft of the first drive mechanism 242 is connected to the second end of the rotating shaft 241. The first drive mechanism 242 is used to drive the plug valve chuck 240 to rotate so that the plug valve 44 switches channels. The first drive mechanism 242 is a servo motor. The first drive mechanism 242 is electrically connected to the second circuit board. The second circuit board controls the rotation of the first drive mechanism 242.

[0080] In one embodiment of the present invention, the plug valve chuck assembly 24 further includes an origin sensing mechanism and a first sensor mechanism. The origin sensing mechanism includes a second sensor 245 and an origin sensing plate 246. The origin sensing plate 246 is sleeved on the outer periphery of the rotating shaft 241 and located between the angle position sensing plate 244 and the plug valve chuck 240. The origin sensing plate 246 is coaxially arranged with the rotating shaft 241. A second notch is provided on the edge of the origin sensing plate 246. The second sensor 245 is connected to the motor mounting plate 257 and is used to detect whether the origin sensing plate 246 is in the initial position. The second sensor 245 is electrically connected to a second circuit board, and the type of the second sensor 245 is the same as that of the first sensor 243. When the second notch of the origin sensing plate 246 rotates to align with the second sensor 245, the second sensor 245 outputs an electrical signal to the second circuit board, indicating that the origin sensing plate 246 has rotated to the initial position.

[0081] The first sensor mechanism includes a first sensor 243 and an angle position sensing plate 244, which is sleeved on the outer periphery of the rotating shaft 241. Preferably, a retaining ring 249 is sleeved on the outer periphery of the rotating shaft 241. The retaining ring 249 is located on the side of the angle position sensing plate 244 away from the stopcock valve clamp 240, and abuts against the angle position sensing plate 244 to limit its movement. Multiple first notches are spaced at intervals along the edge of the angle position sensing plate 244. The first sensor 243 is connected to the motor mounting plate 257 and is used to detect the rotation angle of the angle position sensing plate 244. The first sensor 243 is a photoelectric sensor and is electrically connected to the second circuit board.

[0082] When the angle position sensor 244 rotates until the first notch aligns with the first sensor 243, the light beam emitted from the output end of the first sensor 243 passes through the first notch and is received by the receiving end of the first sensor 243. The first sensor 243 then outputs an electrical signal to the second circuit board, representing the rotation of the angle position sensor 244 by a predetermined angle. Since the distance between two adjacent first notches is equal, the second circuit board can calculate the rotation angle of the angle position sensor 244 based on the number of received electrical signals.

[0083] It should be noted that the more first notches there are, the higher the detection accuracy of the first sensor 243. The specific number of first notches is determined according to actual needs. The specific structural form of the first notch is not limited to a notch; a through hole can also be used instead of a first notch.

[0084] In one embodiment of the present invention, such as Figure 5 and Figure 10 As shown, the cell dispensing device 2 also includes an industrial camera 270 and a bubble sensor group 271, which are disposed on one side of the dispensing housing 21. The bubble sensor group 271 includes multiple first bubble sensors, which are spaced apart along the width direction of the dispensing housing 21. The positions of the first bubble sensors correspond one-to-one with the positions of the liquid tubing 42 on the consumable 4, and the first bubble sensors are used to detect the presence of bubbles in the liquid tubing 42. The industrial camera 270 is located above the bubble sensor group 271 and is used to detect the presence of bubbles in the liquid tubing 42. The liquid tubing 42 is connected to the formulation bag. During use, the liquid tubing 42 is in a vertical state and is stretched, reducing its outer diameter. This reduces the frictional resistance of the liquid tubing 42 when it is inserted into the first bubble sensor, enabling rapid installation of the tubing.

[0085] In one embodiment of the present invention, Figure 2As shown, the cell dispensing device 2 also includes a second bubble sensor 272. The second bubble sensor 272 is disposed on one side of the dispensing housing 21 and is electrically connected to the second circuit board. The second bubble sensor 272 is used to detect whether there are bubbles in the input tube of the consumable 4.

[0086] In one embodiment of the present invention, a cell dispensing module alarm light 273, a consumable installation confirmation key 274, and a cell dispensing module power key 275 are also provided on one side of the dispensing housing 21. All three are electrically connected to the second circuit board. The cell dispensing module alarm light 273 flashes when an abnormality occurs in the cell dispensing device 2 to alert the operator to intervene promptly. The consumable installation confirmation key 274 controls the stopcock valve clamp assembly 24, syringe support plate 221, and syringe clamping plate 222 to return to their initial positions when installing consumable 4, facilitating the installation of consumable 4. The cell dispensing module power key 275 controls the opening or closing of the cell dispensing device 2.

[0087] The present invention also provides a multifunctional automated precision cell dispensing device, which includes the cell dispensing device 2 described in any of the above embodiments.

[0088] In one embodiment of the present invention, the multifunctional automated precision cell dispensing equipment further includes a control device 3 and a cell constant temperature mixing device 1. The control device 3 is provided with multiple connection ports. The cell constant temperature mixing device 1 is used to mix the cell fluid in the cell preparation bag evenly at a predetermined temperature. Both the cell dispensing device 2 and the cell constant temperature mixing device 1 are electrically connected to their respective connection ports. Preferably, both the cell dispensing device 2 and the cell constant temperature mixing device 1 are electrically connected to their respective connection ports via aviation plugs.

[0089] Because the cell dispensing device 2, the control device 3, and the cell constant temperature shaking device 1 are arranged in a modular manner, and the control device 3 is equipped with multiple connection ports, the cell dispensing device 2 and the cell constant temperature shaking device 1 are electrically connected to the corresponding connection ports. During the installation process, different numbers of cell dispensing devices 2 can be installed according to actual needs, thereby dispensing different numbers of formulation bags, which is compatible with different scales of production needs.

[0090] In one embodiment of the present invention, such as Figure 11As shown, the cell constant temperature shaking device 1 includes a shaking shell 11, a first circuit board, a constant temperature component 12, a shaking component 13, and a heat-insulating opening and closing door 14. An opening is provided on one side of the shaking shell 11. The first circuit board is disposed inside the shaking shell 11 and electrically connected to a corresponding connection port. The constant temperature component 12 is disposed inside the shaking shell 11 and electrically connected to the first circuit board. The constant temperature component 12 is used to control the temperature inside the shaking shell 11 to keep the cell preparation bag in a predetermined constant temperature environment. The shaking component 13 is disposed inside the shaking shell 11 and electrically connected to the first circuit board. The shaking component 13 is used to mix the cell fluid in the cell preparation bag evenly at a predetermined temperature. The heat-insulating opening and closing door 14 is located at the opening of the shaking shell 11 and is provided with glass 15. Preferably, the heat-insulating opening and closing door 14 is provided with double-layered glass. By using double-layered glass, the temperature-insulating capacity inside the shaking shell 11 is enhanced, power loss is reduced, and condensation is minimized.

[0091] In one embodiment of the present invention, such as Figure 12 As shown, the control device 3 includes a housing 31, a main control circuit board, and a display screen 32. The main control circuit board is located inside the housing 31 and is electrically connected to multiple connection ports. The display screen 32 is connected to the housing 31 via a movable arm 33. By fixing the display screen 32 with the movable arm 33, the angle of the display screen 32 can be adjusted as needed, making it more convenient to use. The display screen 32 is electrically connected to the main control circuit board and is used to display the operating parameters of the cell dispensing device 2 and the cell constant temperature shaking device 1.

[0092] In one embodiment of the present invention, a power button 34, an alarm light 35, and a data cable interface 36 are provided on one side of the outer casing 31. These components are all electrically connected to the main control circuit board. The power button 34 controls the opening and closing of the control device 3. The alarm light 35 triggers an alarm when the main control circuit board detects an abnormality, alerting the operator to intervene promptly. The data cable interface 36 is used to connect to an external interface; preferably, it is a USB interface.

[0093] In one embodiment of the present invention, a speaker is also provided on one side of the outer casing 31. The speaker is electrically connected to the main control circuit board and is used to play voice information output by the main control circuit board.

[0094] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A cell dispensing device, characterized in that, include: The packaging shell (21) has an internal cavity; The syringe push-pull component (22) includes a first linear drive assembly (220), a syringe support plate (221), a syringe clamping plate (222), and a positioning assembly (224). The first linear drive assembly (220) is disposed in the cavity and connected to the dispensing housing (21). The syringe support plate (221) is connected to the first linear drive assembly (220). The positioning assembly (224) is disposed in the dispensing housing (21) and is used to position and cooperate with the syringe. The first linear drive assembly (220) is used to drive the syringe support plate (221) and the syringe clamping plate (222) to move along a first direction. The first linear drive assembly (220) is used to drive the syringe support plate (221) and the syringe clamping plate (222) to move along a first direction, so as to drive the piston rod of the syringe to move up and down along the first direction, so as to make the syringe dispense or dispense liquid.

2. The cell dispensing device according to claim 1, characterized in that, The syringe push-pull component (22) also includes: The second linear drive assembly (223) is disposed on the syringe support plate (221) and connected to the syringe clamping plate (222); the second linear drive assembly (223) is used to drive the syringe clamping plate (222) to move closer to or away from the syringe support plate (221) in a first direction, so as to clamp or release the bottom of the syringe piston.

3. The cell dispensing device according to claim 2, characterized in that, The syringe clamping plate (222) has a limiting groove (225) at its first end. The syringe clamping plate (222) is engaged with the end of the syringe plunger through the limiting groove (225). The second end of the syringe clamping plate (222) is connected to the second linear drive assembly (223).

4. The cell dispensing device according to claim 2, characterized in that, The syringe clamping plate (222) has a slot at its second end, and the telescopic shaft of the second linear drive assembly (223) has a floating joint (226) that engages with the slot.

5. The cell dispensing device according to claim 1, characterized in that, The syringe holder (221) has a limiting hole (227) at its first end, and the syringe holder (221) is fitted onto the syringe through the limiting hole (227). The second end of the syringe holder (221) is connected to the first linear drive assembly (220).

6. The cell dispensing apparatus according to any one of claims 1 to 5, characterized in that, The first linear drive assembly (220) includes: First linear drive (228); A connecting mechanism (229) is provided, through which the first linear drive (228) is connected to the second end of the syringe tray (221); The fixing plate (230) is connected to the first linear drive (228) and the sub-assembly housing (21).

7. The cell dispensing device according to claim 6, characterized in that, The syringe push-pull component (22) also includes: The first sensor assembly includes a first position sensor (231) and a first position sensing plate (232), wherein the first position sensor (231) is disposed on the first linear drive member (228) and the first position sensing plate (232) is disposed on the connecting mechanism (229).

8. The cell dispensing device according to claim 6, characterized in that, The syringe push-pull component (22) also includes: The second sensor assembly includes a second position sensor (233) and a second position sensing plate (234). The second position sensor (233) is disposed on the connecting mechanism (229), and the second position sensing plate (234) is disposed on one side of the syringe clamping plate (222).

9. The cell dispensing device according to claim 6, characterized in that, The syringe push-pull component (22) also includes: The guide assembly includes a guide shaft (235) and an oil-free bushing (236). The guide shaft (235) is disposed on one of the syringe support plate (221) and the syringe clamping plate (222), and the oil-free bushing (236) is disposed on the other of the syringe support plate (221) and the syringe clamping plate (222). The oil-free bushing (236) is sleeved on the outer periphery of the guide shaft (235) and slides with the guide shaft (235) in a first direction.

10. The cell dispensing apparatus according to any one of claims 1 to 5, characterized in that, The cell dispensing device further includes: A positioning component (25) is disposed on the packaging housing (21), and the positioning component (25) is used to position and cooperate with the card plate (41) of the consumable (4); A plug valve chuck assembly is disposed in the sub-assembly housing (21), and the plug valve chuck assembly is used to drive the plug valve (44) of the consumable (4) to switch channels.

11. The cell dispensing device according to claim 10, characterized in that, The cell dispensing device further includes: The fixing component (26) includes a rotating handle (261), a connecting shaft (262), a fixing base (263), and a positioning disk (264). The fixing base (263) is connected to the sub-assembly housing (21). The interior of the fixing base (263) is hollow. The positioning disk (264) is rotatably disposed inside the fixing base (263). One end of the connecting shaft (262) is connected to the rotating handle (261), and the other end of the connecting shaft (262) is connected to the positioning disk (264). The outer circumferential surface of the positioning disk (264) is provided with a groove (265). The inner wall of the fixing base (263) is provided with at least one third ball screw (266) that is positioned and engaged with the groove (265). The card plate (41) is provided with a locking hole. The rotating handle (261) locks the card plate (41) through the locking hole.

12. The cell dispensing apparatus according to any one of claims 1 to 5, characterized in that, The positioning component (224) includes a syringe positioning plate (258), which is disposed on one side of the packaging housing (21). The syringe positioning plate (258) has two positioning protrusions (237), which are arranged at intervals in the vertical direction. Both positioning protrusions (237) are provided with snap-fit ​​grooves for snap-fit ​​with the syringe. A positioning groove (238) is formed between the two positioning protrusions (237) for snap-fit ​​with the syringe mounting plate (43).

13. A multifunctional automated precision cell dispensing device, characterized in that, Includes the cell dispensing device according to any one of claims 1 to 12.

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