Phase coherent multi-channel radiofrequency ablation output system and method

Abstract

The invention discloses a phase coherent multichannel radiofrequency ablation output system and method, and relates to the technical field of radiofrequency. The backboard is respectively connected with the core board card, the signal board card and the plurality of radio frequency board cards; the core board card performs data interaction with the signal board card and the plurality of radio frequency board cards through the backboard; the signal board card generates multi-channel phase-coherent radio frequency signals; each radio frequency board card amplifies a radio frequency signal to obtain radio frequency energy and transmits the radio frequency energy to the signal board card through the backboard; and the signal board card performs single and double-pole conversion of radio frequency energy output by using the single and double-pole switching module. According to the multi-channel radio frequency system, the defect that a traditional multi-channel radio frequency system cannot output radio frequency energy at the same time is overcome, each channel can independently output the radio frequency energy, good independence is achieved, and the radio frequency energy can be independently adjusted according to needs; and the purposes of expanding the ablation range, reducing the ablation time and the like can be achieved through mutual influence of the phase relation between the radio frequency board cards.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of radio frequency technology, in particular to a phase coherent multi-channel radio frequency ablation output system and a multi-channel radio frequency ablation output method. BACKGROUND

[0002] At present, multi-channel radio frequency is realized by a relay module to output multi-channel radio frequency. The channel selection in the general multi-channel radio frequency ablation method is realized by a relay module, the control end of which is electrically connected with an MCU control module, and the opening and closing end is electrically connected with a radio frequency energy generation circuit, which is used to divide and transfer radio frequency energy to different output interfaces.

[0003] The multi-channel radio frequency is realized by a relay module, and the radio frequency energy of each channel is essentially the same radio frequency source. Therefore, the radio frequency energy of each channel cannot be output at the same time, and the energy size is the same, which leads to the fact that different energy cannot be selected when multiple different lesions are ablated, and a long time is consumed when a larger lesion is ablated.

[0004] For general multi-channel radio frequency energy ablation, in order to avoid mutual interference between channels, the same radio frequency source is used, and then the radio frequency source is controlled by PWM to ensure the output of multiple channels. Although the output of multiple channels is ensured, simultaneous output cannot be ensured, and good independence cannot be achieved. SUMMARY

[0005] The present application aims to provide a phase coherent multi-channel radio frequency ablation output system and a multi-channel radio frequency ablation output method to overcome the shortcomings in the prior art.

[0006] In a first aspect, the embodiments of the present application provide a phase coherent multi-channel radio frequency ablation output system, comprising: a system host, the system host comprising: a backplane connected with a core board card, a signal board card and a plurality of radio frequency board cards respectively, the backplane receiving electric energy output by a power module and transmitting the electric energy to components connected therewith; The core board card interacts with the signal board card and a plurality of radio frequency board cards through the backplane, performs operation based on the interacted data to obtain an operation result, and generates a control instruction based on the operation result or receives an external operation instruction and transmits the operation instruction to the signal board card through the backplane; The signal board card generates a multi-channel phase coherent radio frequency signal based on the control instruction or the operation instruction and transmits the radio frequency signal to the corresponding radio frequency board card through the backplane, one radio frequency signal corresponding to one radio frequency board card, the signal board card independently closing and opening the radio frequency signal corresponding to each radio frequency board card, and adjusting the phase information of the radio frequency signal between each radio frequency board card according to actual needs; Each of the radio frequency board cards utilizes the bus voltage transmitted by the backplane to amplify the received radio frequency signals to obtain radio frequency energy and transmit the radio frequency energy to the signal board card through the backplane, and detect radio frequency energy parameters and transmit the radio frequency energy parameters to the core board card and the signal board card through the backplane; The signal board card utilizes a single / dual-pole switching module thereof to perform single / dual-pole conversion of radio frequency energy output according to a selected operation mode. The backplane, the core board card, the signal board card, and the plurality of radio frequency board cards share a same system clock. The signal board card performs coherent operation on the radio frequency energy and the radio frequency signals, and a control instruction generated based on an operation result of the coherent operation causes stable phase shifting of the radio frequency board cards. Each of the radio frequency board cards adopts a 32-bit channel frequency tuning word and a 14-bit phase shift offset, and each of the radio frequency board cards is provided with an independent gate driver.

[0007] Optionally, the core board card comprises a core module, a collection card module, and a first connector. An I / O interface, an A / D, and a D\A of the collection card module are connected with the first connector. The collection card module and the core module exchange data through a communication port. The collection card module is connected with the backplane through the first connector, and exchanges data with the signal board card and the plurality of radio frequency board cards through the backplane. The core module sends an analog signal to the plurality of radio frequency board cards through the collection card module and the first connector, to control a size of radio frequency energy of each of the radio frequency board cards.

[0008] Optionally, the core board card further comprises a temperature detection module and a safety warning module. An A / D and a D\A of the temperature detection module are connected with the first connector, and are used to detect a probe temperature and feed back to the collection card module. An I / O interface of the safety warning module is connected with the first connector, and is used to warn and prompt abnormal information based on an instruction of the core module, and provide an output protection measure in an emergency state.

[0009] Optionally, the system host further comprises a display control interaction module. The display control interaction module is connected with the core module through a video port and a communication port, respectively, and is used to receive and process the operation instruction, and display target information on a display device, the target information being data required to be displayed received by the core module and the control instruction and the operation instruction.

[0010] Optionally, the signal board card comprises: a signal generation module, a second connector, a phase detection module, a single-dual pole switching module, a neutral electrode detection module, an impedance switching board card, a 9th order Butterworth low-pass filter, and an external optional REFCLK crystal oscillator. The signal generation module is connected with the backboard through the second connector. The signal generation module comprises: an MCU and a DDS chip. The MCU receives the control instruction or the operation instruction through the backboard, and controls the DDS chip to generate the multi-channel phase-coherent radio frequency signals through an SPI serial port, wherein the number of the radio frequency signals is one more than the number of the radio frequency board cards, and the one more radio frequency signal is used as a phase reference signal inside the signal board card. The phase detection module is connected with the MCU and a radio frequency energy output port respectively, and is used for receiving the phase reference signal, obtaining the amplitude and phase information of the radio frequency energy, and performing phase detection in combination with the phase reference signal, and sending the phase detection result to the MCU, so that the MCU receives the phase detection result while the DDS chip generates the radio frequency signals, and simultaneously adjusts the start-stop, amplitude and phase information of the radio frequency signals between the radio frequency board cards according to actual needs and periodically reports the core board card. The single-dual pole switching module is connected with the radio frequency energy output port, and is used for single-dual pole conversion of the radio frequency energy output according to a selected working mode. The neutral electrode detection module is connected with the radio frequency energy output port and an electrode sheet loop respectively, and is used for monitoring the connection between the radio frequency energy output port and the electrode sheet loop. The impedance switching board card is arranged between the output end of the radio frequency board card and the single-dual pole switching module, and is used for adjusting the impedance of the radio frequency energy to match the impedance of the treatment site according to the different impedance of the treatment site. The output end of each radio frequency signal is connected with the 9th order Butterworth low-pass filter in series, and the radio frequency signal is transmitted to the corresponding radio frequency board card through the backboard after being filtered by the 9th order Butterworth low-pass filter. When the external optional REFCLK crystal oscillator is selected to be used, the crystal oscillator in the MCU stops working, and the clock of the DDS chip is provided by the external optional REFCLK crystal oscillator.

[0011] Optionally, each radio frequency board card comprises: a radio frequency board card connector, a drive amplifier, a field effect tube, a harmonic network, a coupling circuit, and a voltage and current feedback network. The driving amplifier is connected with the radio frequency board connector, the field effect tube respectively, and is used for receiving radio frequency signals and analog signals, amplifying the radio frequency signals to generate an amplified signal to control the on-off of the field effect tube; The field effect tube is connected with the resonant network, and is used for generating radio frequency energy with noise based on the amplified signal and transmitting to the resonant network; The resonant network is connected with the coupling circuit, and is used for filtering the radio frequency energy with noise to obtain stable radio frequency energy and transmitting to the coupling circuit; The coupling circuit is connected with the voltage and current feedback network, the signal board respectively, and is used for transmitting the stable radio frequency energy to the voltage and current feedback network and the signal board; The voltage and current feedback network comprises a voltage coupler, a current coupling circuit and an operational amplifier circuit, the voltage and current signals are obtained by coupling the stable radio frequency energy through the voltage coupler and the current coupling circuit, and the voltage and current signals are amplified and isolated through the operational amplifier circuit, and are transmitted to the core board through the backboard, so that the core board calculates based on the voltage and current signals to obtain the output power of the radio frequency energy; The output end of each radio frequency board is connected with an impedance switching board through an SMA connector; The isolation degree between adjacent radio frequency boards is greater than 65dB.

[0012] Optionally, the backboard comprises a connector female head; The backboard is connected with the connector male head of the core board, the connector male head of the signal board and the connector male head of each radio frequency board through the connector female head; The connector female head is a 180° straight pin female seat, and the connector male head is a 90° bent pin male seat. In a second aspect, the embodiments of the present application provide a phase-coherent multi-channel radio frequency ablation output method, which is applied to the phase-coherent multi-channel radio frequency ablation output system of any one of the first aspect, and comprises: The power supply module supplies power to all the board cards through the backboard; The core board card performs self-checking after being powered on, and receives the operation instruction after the self-checking is normal; The core board card generates an information instruction based on the operation instruction and transmits the information instruction to the signal board card through the backboard; The signal board card generates an initial radio frequency signal based on the information instruction and transmits the initial radio frequency signal to the target radio frequency board card through the backboard; The target radio frequency board card amplifies the initial radio frequency signal and transmits the amplified initial radio frequency signal to the signal board card through the backboard; The signal board card switches the single / dual-pole output of the radio frequency energy by using the single / dual-pole switching module according to the selected working mode, and detects the actual parameters of the radio frequency energy to obtain radio frequency energy data and transmits the radio frequency energy data to the core board card through the backplane; The core board card operates the radio frequency energy data to obtain an operation result, and generates the control instruction based on the operation result and transmits the control instruction to the signal board card through the backplane; The signal board card adjusts or does not adjust the initial radio frequency signal based on the control instruction, generates a corresponding radio frequency signal, and transmits the corresponding radio frequency signal to the target radio frequency board card through the backplane, and the corresponding radio frequency signal makes the phase shift generated by each radio frequency board card stable and phase coherent; While the radio frequency energy is continuously output, the core board card performs periodic self-checking, and controls the operation of the multi-channel radio frequency ablation output system according to the result of the periodic self-checking.

[0013] 12. The multi-channel radio frequency ablation output method according to claim 11, wherein the operation instruction comprises: bipolar single-channel output, and required radio frequency energy parameters; and the signal board card generating a multi-channel phase coherent radio frequency signal based on the operation instruction comprises: the signal board card switches to bipolar single-channel output by using the single / dual-pole switching module; the signal board card generates a single-channel radio frequency signal with a working frequency and a preset working amplitude by using a signal generation module according to the required radio frequency energy parameters.

[0014] 13. The multi-channel radio frequency ablation output method according to claim 11, wherein the operation instruction comprises: unipolar multi-channel output, and required radio frequency energy parameters; and the signal board card generating a multi-channel phase coherent radio frequency signal based on the operation instruction comprises: the signal board card switches to unipolar multi-channel output by using the single / dual-pole switching module; after the signal board card receives the frequency and the preset phase threshold value in the required radio frequency energy parameters by using the MCU in the signal generation module, the signal board card issues an instruction to the DDS chip, the DDS chip generates a multi-channel radio frequency signal, and sets the phase difference of the radio frequency signals between the radio frequency board cards; the signal board card uses a phase discrimination module to discriminate the phase information of the radio frequency energy output by each radio frequency board card, and determines whether the radio frequency energy output by each radio frequency board card meets the preset phase threshold value; if not, the preset phase threshold value is adjusted again until the adjusted preset phase threshold value and the phase difference meet the purpose of phase coherence between the radio frequency board cards; if yes, the purpose of phase coherence between the radio frequency board cards is achieved, the phase values of the corresponding radio frequency signals of the radio frequency board cards are locked, and the corresponding multi-channel radio frequency signal is generated.

[0015] 14. The multi-channel radio frequency ablation output method of claim 12, wherein the core board card performs periodic self-checking and controls operation of the multi-channel radio frequency ablation output system according to a result of the periodic self-checking, comprising: the core board card uses a core module to perform operation on received radio frequency energy data to obtain power of the radio frequency energy; the core board card uses a temperature detection module to detect temperature of an energy bearing system, which is cooled by a cooling system circulating cooling liquid in the energy bearing system to cool the energy bearing system, the energy bearing system including a probe; the core board card uses a safety warning module to detect connection conditions of each board card and accessories; if the operation result does not satisfy a preset power value, the core board card uses the core module to perform operation again to generate a new control instruction, so that the power of the radio frequency energy satisfies the preset power value; if the temperature detection is out of limit or a safety warning occurs, the periodic self-checking fails, the core board card uses the core module to generate a new control instruction to automatically reduce output of the radio frequency energy and determine whether the periodic self-checking can be passed again; if the periodic self-checking still fails, the core board card records radio frequency energy data and stops working, and enters a power-on self-checking state to detect connection conditions of each board card and each accessory; if the periodic self-checking passes, the multi-channel radio frequency ablation output system outputs the radio frequency energy after the radio frequency energy is automatically reduced.

[0016] 15. The multi-channel radio frequency ablation output method of claim 13, wherein the core board card performs periodic self-checking and controls operation of the multi-channel radio frequency ablation output system according to a result of the periodic self-checking, comprising: the core board card uses a core module to perform operation on received radio frequency energy data to obtain power of the radio frequency energy; the signal board card uses a phase detection module to detect phase conditions among the plurality of radio frequency board cards; the core board card uses a temperature detection module to detect temperature of an energy bearing system, which is cooled by a cooling system circulating cooling liquid in the energy bearing system to cool the energy bearing system, the energy bearing system including a probe; the core board card uses a safety warning module to detect connection conditions of each board card and accessories; if the operation result does not satisfy a preset power value, the core board card uses the core module to perform operation again to generate a new control instruction, so that the power of the radio frequency energy satisfies the preset power value; If the temperature detection exceeds the standard or a safety warning appears, the periodic self-check fails, and the signal board card determines whether the phases of the multiple radio frequency board cards are in phase; If the phases are not in phase, the signal board card uses a signal generation module to readjust the phase information of the multiple radio frequency signals until the phases of the multiple radio frequency board cards are in phase, and determines whether the periodic self-check can pass again; If the phases are in phase or the periodic self-check still fails, the core board card uses a core module to generate a new control instruction to automatically reduce the output of the radio frequency energy, and determines whether the periodic self-check can pass again; If the periodic self-check still fails, the core board card records the radio frequency energy data and stops working, and enters a power-on self-check state to detect the connection of each board card and each accessory; If the periodic self-check passes, the multi-channel radio frequency ablation output system outputs the radio frequency energy after the radio frequency energy is automatically reduced.

[0017] 16. The multi-channel radio frequency ablation output method of claim 11, wherein the core board card obtains an operation result by operating the phase shift between the radio frequency energy and the radio frequency signal, and generates the control instruction to make the phase shift generated by each radio frequency board card stable and in phase; The specific method of operating the phase shift between the radio frequency energy and the radio frequency signal includes: The phase shift generated by the radio frequency board card after any radio frequency signal enters the radio frequency board card The formula is as follows:

[0018] In the formula, D D represents the duty cycle, G represents the susceptance of the parallel capacitor, B represents the conductance of the series inductor, T represents the delay caused by the Class-E form amplifier, T represents the delay caused by the matching network, T represents the delay caused by various devices and wiring; The output end of the field effect transistor in the radio frequency board card is connected in parallel with a capacitor and in series with an inductor. After normalization processing, the parallel capacitor and the series inductor are represented by B and G, respectively, and the relationship between the parallel capacitor and the series inductor and the load, respectively, and the voltage amplitude generated by the parallel capacitor and the series inductor, respectively, V R , V L The formulas are as follows:

[0019]

[0020] The series inductance and parallel capacitance are in the best matching state, and the following mathematical relationship is obtained:

[0021] The phase shift generated by the radio frequency board card Is:

[0022] In the above formula, C Cp represents the capacitance of the parallel capacitor, L Ls represents the inductance of the series inductor, v Vu represents the transient voltage in the circuit, I R IL represents the load current; According to the formula of the phase shift generated by the radio frequency board card, the phase shift generated by the radio frequency board card Is a constant; For the impedance matching circuit, the phase shift generated by the impedance matching circuit Is as follows:

[0023] In the above formula, α 0 represents a general constant, which is equal to , C P Cp represents the coupling capacitance of the impedance matching circuit, R L ZL represents the load impedance of the system, R S ZL represents the load impedance of the Class-E form amplifier; The phase shift of the impedance matching board card is related to the load, and the phase shift generated by the radio frequency board card is a constant, so the core board card adjusts the phase threshold and phase difference of the multi-path radio frequency signal in real time according to the actual accessed load; The microstrip lines are used to connect the board cards, and the phase shift generated by the microstrip lines Is as follows:

[0024] Wherein,

[0025] In the above formula, Is a value between the dielectric constant of the substrate substrate And the dielectric constant of air 1, λ 0 represents the free space wavelength.

[0026] Compared with the prior art, the positive effects of the present application are: The multi-channel radio frequency ablation output system provided in the application has a system host adopting a VME architecture, and various board cards are tightly coupled and can perform interconnection data processing, and the connection of peripheral devices is simple, and each board card can be independently maintained, replaced and upgraded.

[0027] The multi-channel radio frequency ablation output system adopts output radio frequency output energy and radio frequency signals generated by a signal board card to be in phase, so as to ensure that the final output result is stable and reliable, and the offset between the radio frequency board cards does not affect each other. In a single polarity multi-channel output mode, independent control and monitoring of each radio frequency board card are realized, so that the size of the radio frequency energy of each radio frequency board card can be independently controlled according to the size of each lesion; when facing a larger lesion, multiple channels can work at the same time, and by using the phase-in-phase relationship between each other, the ablation range is expanded and the ablation time is shortened. In addition, the user can also switch between single polarity multi-channel output and bipolar single channel output according to the needs, without manual setting.

[0028] The multi-channel radio frequency ablation output system provided in the application overcomes the defect that the traditional multi-channel radio frequency system cannot simultaneously output radio frequency energy, can independently output radio frequency energy of each channel, has good independence, and can also independently adjust the radio frequency energy according to the needs; and can also affect each other through the phase relationship between each radio frequency board card to expand the ablation range while reducing the ablation time, and has excellent practicability. BRIEF DESCRIPTION OF DRAWINGS

[0029] The above and / or additional aspects and advantages of the present application will become apparent and more readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings, in which: Figure 1 A system architecture schematic diagram of a phase-in-phase multi-channel radio frequency ablation output system of an embodiment of the present application; Figure 2 A structure schematic diagram of an exemplary and relatively optimal core board card in an embodiment of the present application; Figure 3 A structure schematic diagram of an exemplary and relatively optimal signal board card in an embodiment of the present application; Figure 4 A structure schematic diagram of a single-dual-pole switching module switching single pole and dual pole in an embodiment of the present application; Figure 5 A structure schematic diagram of an exemplary and relatively optimal radio frequency board card in an embodiment of the present application; Figure 6 A structure schematic diagram of an exemplary and relatively optimal backplane in an embodiment of the present application; Figure 7 A flowchart of a phase-in-phase multi-channel radio frequency ablation output method of an embodiment of the present application. DETAILED DESCRIPTION

[0030] The embodiments of the present application will be described in detail below with reference to the accompanying drawings, in which the same or similar components have the same or similar reference numbers throughout the drawings and a description thereof will not be repeated. The embodiments described below with reference to the accompanying drawings are exemplary and are for the purpose of explanation only and are not to be understood as limiting the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor are within the scope of protection of the present application.

[0031] The embodiments of the present application provide a phase coherent multi-channel radio frequency ablation output system, referring to Figure 1 The system architecture schematic diagram of the multi-channel radio frequency ablation output system is shown, which includes a system host, the system host includes a backboard, a core board card, a signal board card, and a plurality of radio frequency board cards. Figure 1 The radio frequency board card 1, the radio frequency board card 2, and the radio frequency board card N are exemplarily shown.

[0032] The backboard is connected with the core board card, the signal board card, and the plurality of radio frequency board cards respectively, the backboard receives the electric energy output by the power module and transmits the electric energy to the components connected therewith; the backboard can be understood as a connection board which connects the power module and all the board cards to transmit the electric energy and various data.

[0033] The core board card performs data interaction with the signal board card and the plurality of radio frequency board cards through the backboard, performs operation based on the data of the interaction to obtain an operation result, and generates a control instruction based on the operation result or receives an external operation instruction and transmits it to the signal board card through the backboard. Among them, the external operation instruction is generally an instruction issued by a relevant person manually. For example, the relevant person can operate through the keys or touch screen of the therapeutic instrument to generate the corresponding operation instruction.

[0034] The signal board card generates multi-channel phase coherent radio frequency signals based on the control instruction or the operation instruction and transmits them to the corresponding radio frequency board cards through the backboard, one radio frequency signal corresponds to one radio frequency board card, the signal board card can also independently turn off and turn on the radio frequency signals corresponding to each radio frequency board card, and adjust the phase information of the radio frequency signals between the radio frequency board cards according to the actual demand.

[0035] Each radio frequency board card uses the bus voltage transmitted through the backboard to amplify the received radio frequency signals to obtain radio frequency energy and transmits it to the signal board card through the backboard, and detects the radio frequency energy parameters and transmits them to the core board card and the signal board card through the backboard.

[0036] The signal board card uses a single / double pole switching module to convert the single / double pole of the RF energy output according to the selected working mode, that is, the signal board card not only generates RF signals, but also receives the RF energy generated by the RF board card and outputs it externally.

[0037] In the system host structure, the backplane, the core board card, the signal board card and the plurality of RF board cards share the same system clock. The signal board card performs coherent operation on the RF energy and the RF signal, and the control instruction generated based on the operation result can make the phase shift generated by each RF board card stable and coherent. Each RF board card uses a 32-bit channel frequency tuning word and a 14-bit phase shift offset, and each RF board card is provided with an independent gate driver.

[0038] The system host of the present application can preferably use the VME architecture, so that the various board cards are tightly coupled, the board cards can interconnect data processing, have the advantage of simple connection of peripheral devices, and each board card can be independently maintained, replaced and upgraded.

[0039] It can be understood that the matching system host naturally has related accessories, including but not limited to: footswitch, device connection pipe, device connection line, neutral electrode connection line, power supply line, sealing connector, instrument shell, etc. The accessories and the system host are assembled to obtain a multi-channel RF therapeutic instrument for treating lesions.

[0040] In an embodiment of the present application, the core board card preferably comprises: a core module, a collection card module and a first connector; the I / O interface, A / D and D\A of the collection card module are connected with the first connector; the collection card module and the core module exchange data through a communication port; the collection card module is connected with the backplane through the first connector, and exchanges data with the signal board card and the plurality of RF board cards through the backplane; the core module sends analog signals to the plurality of RF board cards through the collection card module and the first connector to control the size of the RF energy of each RF board card.

[0041] In addition, since the temperature of the probe needs to be detected, and abnormal information needs to be detected and reminded in time, the core board card preferably further comprises: a temperature detection module and a safety warning module. The A / D and D\A of the temperature detection module are connected with the first connector, which is used to detect the temperature of the probe and feed back to the collection card module; the I / O interface of the safety warning module is connected with the first connector, which is used to warn and prompt abnormal information based on the instruction of the core module and provide output protection measures in emergency state. These detected data also need to be sent to the core module for corresponding processing.

[0042] In one embodiment of this application, the system host may preferably further include a display and control interaction module; this module is connected to the core module via a video port and a communication port, and is used to receive and process operation commands, and to display target information on a display device. The target information includes the data to be displayed, control commands, and operation commands received by the core module. That is, the display and control interaction module corresponds to a display and control screen, and operation commands from relevant personnel can be transmitted to the core module in this way. Simultaneously, various relevant information during the treatment process can also be displayed on the display and control screen.

[0043] To better understand the structure of the aforementioned core board, refer to... Figure 2 The diagram shows a schematic of an exemplary preferred core board. Figure 2 The interactive module - display and control (industrial screen) is the display and control interactive module, which connects to the core module via an HDMI video port and a USB communication port. The data acquisition card module and the core module exchange data via the USB communication port. The I / O interfaces, A / D, D / A converters of the data acquisition card module are connected to the first connector (…). Figure 2 (Using the male connector head in Chinese) connection. Figure 2 For simplicity in the illustration, the backplate is omitted; instead, the connector male plugs directly connect to the signal and RF boards. The following... Figure 3 , Figure 4 , Figure 6 The backplate is also omitted, and the board is directly connected to other boards via male connectors.

[0044] The core board serves as the underlying data acquisition and transmission module. Its main functions include: exchanging data with other boards via the backplane, transmitting data from each board back to the core board, and distributing control commands from that board; processing the real-time data transmitted from each board and issuing control commands based on the results, while simultaneously transmitting the results and relevant data to be displayed to the interaction module; receiving and processing user commands and providing feedback on display requirements through the interaction module; detecting probe temperature; providing alerts for abnormal information, such as buzzer alarms; and providing output protection measures in emergency situations, such as forced shutdown.

[0045] The interactive module – display and control (industrial screen) – enables user-interface interaction. It displays the user interface (UI) and plots real-time curves and graphs of treatment parameters, while providing users with input for several treatment parameters and virtual control buttons. Startup and shutdown functions are also implemented through the interactive module.

[0046] In an embodiment of the present application, the signal board card preferably comprises a signal generation module and a second connector; the signal generation module is connected to the backplane through the second connector; the signal generation module comprises an MCU and a DDS chip.

[0047] The MCU receives control instructions or operation instructions through the backplane and controls the DDS chip to generate multi-channel phase-coherent radio frequency signals through an SPI serial port, wherein the number of radio frequency signals is one more than the number of radio frequency board cards, and the extra one radio frequency signal serves as a phase reference signal inside the signal board card.

[0048] Preferably, the signal board card further comprises a phase detection module, a single-dual-pole switching module, a neutral electrode detection module, and an impedance switching board card. The phase detection module is connected to the MCU and the radio frequency energy output port respectively, and is used to receive the phase reference signal, obtain the amplitude and phase information of the radio frequency energy, and perform phase detection in combination with the phase reference signal, and send the phase detection result to the MCU, so that the MCU receives the phase detection result while the DDS chip generates the radio frequency signal, and simultaneously adjusts the start-stop, amplitude and phase information of the radio frequency signal between the radio frequency board cards according to actual needs and periodically reports to the core board card.

[0049] The single-dual-pole switching module is connected to the radio frequency energy output port, and is used to perform single-dual-pole conversion of the radio frequency energy output according to the selected working mode; the neutral electrode detection module is connected to the radio frequency energy output port and the electrode sheet loop respectively, and is used to monitor the connection between the radio frequency energy output port and the electrode sheet loop.

[0050] In order to better understand the structure of the core board card, refer to Figure 3 the structure of an exemplary preferred signal board card is shown in the structure diagram. Figure 3 Among them, signal generation represents the signal generation module, and DDS represents the DDS chip. Figure 3 For the sake of simplicity of illustration, three radio frequency board cards are shown schematically, so there are four DDS chips, generating four radio frequency signals, of which three radio frequency signals RF_IN1, RF_IN2, and RF_IN3 are transmitted to radio frequency board card 1, radio frequency board card 2, and radio frequency board card 3 respectively, and the radio frequency signal RF phase is transmitted to the phase detection module as a phase reference signal. PORT1, PORT2, and PORT3 represent radio frequency energy output ports respectively.

[0051] The impedance switching board card is arranged between the output end of the radio frequency board card and the single-dual pole switching module, and is used for adjusting the impedance of the radio frequency energy to match the impedance of the treatment site according to the difference of the impedance of the treatment site. Generally, the impedance of each part of the human body is different, for example, the impedance of the liver is different from the impedance of the spleen, and is also different from the impedance of the kidney, the heart and the lung. Therefore, in the actual treatment process, for different treatment sites, the corresponding impedance is different, and it is necessary to adjust the impedance of the radio frequency energy to match the impedance of the treatment site, and the role of the impedance switching board card is in this case.

[0052] The phase detection module is connected with the MCU and the radio frequency energy output port respectively, and is used for receiving the phase detection reference signal RF phase detection, obtaining the amplitude and phase information of the radio frequency energy, and performing phase detection combined with the phase detection reference signal RF phase detection, and sending the phase detection result to the MCU. The MCU receives the phase detection result while the DDS chip generates the radio frequency signal, and simultaneously adjusts the start-stop, amplitude and phase information of the radio frequency signal between the radio frequency board cards according to the actual demand and periodically reports to the core board card.

[0053] The single-dual pole switching module is connected with the radio frequency energy output port, and is used for converting the single-dual pole of the radio frequency energy output according to the selected working mode. The main function of the single-dual pole switching module is to control the switching between the single pole and the dual pole of the radio frequency output, and three ports can be freely switched taking three radio frequency board cards as an example. In an embodiment of the present application, an exemplary single-dual pole switching module switching the single pole and the dual pole is shown in 4.

[0054] Figure 4 SPST represents a switch, the radio frequency signal 1 is the aforementioned RF_IN1, and RF1 represents the radio frequency energy output port. Through this single-dual pole switching module, when the multi-channel radio frequency ablation output system works in the mode of bipolar single-path output, the radio frequency energy output port RF1 can be the positive pole, the radio frequency energy output port RF2 can be the negative pole, or the radio frequency energy output port RF1 can be the negative pole, the radio frequency energy output port RF2 can be the positive pole, or the radio frequency energy output port RF1 can be the negative pole, the radio frequency energy output port RF3 can be the positive pole, or the radio frequency energy output port RF1 can be the positive pole, the radio frequency energy output port RF3 can be the negative pole, or the radio frequency energy output port RF2 can be the positive pole, the radio frequency energy output port RF3 can be the negative pole, or the radio frequency energy output port RF2 can be the negative pole, the radio frequency energy output port RF3 can be the positive pole.

[0055] When the multi-channel radio frequency ablation output system works in the mode of single polarity multi-path output, the radio frequency energy output ports RF1, RF2 and RF3 can be positive poles, the corresponding probes are placed at the treatment site, and the electrode pads connected by the neutral electrode 1 and the neutral electrode 2 are placed at the non-treatment site as negative poles. The neutral electrode detection module is connected with the radio frequency energy output ports and the electrode pad loop respectively, and is used for monitoring the connection between the radio frequency energy output ports and the electrode pad loop; if the electrode pad is not placed at the non-treatment site, there is no voltage difference between the radio frequency energy output ports RF1, RF2 or RF3 and the neutral electrode 1 or the neutral electrode 2, indicating that the connection is disconnected.

[0056] In addition, considering that the clock provided by the crystal oscillator of the MCU itself cannot meet the generation of multiple radio frequency signals by a large number of DDS chips, for example, the clock provided by the crystal oscillator of the MCU itself only meets the generation of 4 radio frequency signals by 4 DDS chips, and the required radio frequency signals are 5 or more, an external optional REFCLK crystal oscillator needs to be additionally arranged to replace the crystal oscillator of the MCU itself. When the external optional REFCLK crystal oscillator is selected to be used, the crystal oscillator in the MCU stops working, and the clock of the DDS chip is provided by the external optional REFCLK crystal oscillator.

[0057] In order to ensure the purity of the output frequency of the signal source, that is, to ensure the purity of the output frequency of the radio frequency signal, preferably, a 9th order Butterworth low-pass filter can be connected in series at the output end of each radio frequency signal. After being filtered by the 9th order Butterworth low-pass filter, the radio frequency signal is transmitted to the corresponding radio frequency board card through the backboard.

[0058] The main function of the signal board card is to generate multiple phase-coherent radio frequency signals, that is, multiple radio frequency signals, which make the phases of the radio frequency board cards phase-locked after subsequent adjustment. The signal board card can independently turn off and turn on the corresponding radio frequency signal of each radio frequency board card according to the control instruction, and adjust the phase information between the radio frequency board cards according to the actual demand. In addition, it is also responsible for the single / double pole conversion of the radio frequency energy output, the detection of the neutral electrode board and the amplitude and phase detection functions of each radio frequency energy.

[0059] In an embodiment of the present application, for each radio frequency board card, preferably, it comprises a radio frequency board card connector, a drive amplifier, a field effect tube, a harmonic network, a coupling circuit and a voltage and current feedback network.

[0060] The drive amplifier is connected with the radio frequency board card connector and the field effect tube respectively, which is used to receive the radio frequency signal and the analog signal, amplify the radio frequency signal to generate an amplified signal to control the on-off of the field effect tube; the field effect tube is connected with the resonant network, which is used to generate radio frequency energy with noise based on the amplified signal and transmit it to the resonant network.

[0061] The resonant network is connected with the coupling circuit, and is used for filtering the radio frequency energy with the noise to obtain stable radio frequency energy and transmitting the stable radio frequency energy to the coupling circuit; the coupling circuit is connected with the voltage and current feedback network and the signal board card respectively, and is used for transmitting the stable radio frequency energy to the voltage and current feedback network and the signal board card.

[0062] The voltage and current feedback network comprises a voltage coupler, a current coupling circuit and an operational amplifier circuit, the voltage and current signals are obtained by coupling the stable radio frequency energy by the voltage coupler and the current coupling circuit, the voltage and current signals are amplified and isolated by the operational amplifier circuit, and are transmitted to the core board card through the back plate, so that the core board card performs operation based on the voltage and current signals to obtain the output power of the radio frequency energy.

[0063] Preferably, the output end of each radio frequency board card is connected with the impedance switching board card by using an SMA connector; the isolation degree between adjacent radio frequency board cards is greater than 65dB.

[0064] In order to better understand the structure of the radio frequency board card, refer to Figure 5 for an exemplary preferred structure diagram of the radio frequency board card. Figure 5 In the figure, the connector male head represents the radio frequency board card connector, the field effect tube is represented by MOS, and the field effect tube MOS needs a bias circuit for working. The voltage coupler, the current coupling circuit and the operational amplifier circuit are represented by a voltage detection module, a current detection module respectively; the analog signal is represented by a DA signal, which comes from the core board card.

[0065] The main function of the radio frequency board card is to amplify and detect the small signal (radio frequency signal) from the signal board card. The radio frequency board card realizes the generation and controlled adjustment output of the fixed frequency radio frequency energy with higher power and larger impedance dynamic range according to the control instruction of the core board card, and realizes the isolation of the output end. At the same time, the voltage and current detection modules detect the voltage-current characteristic of the radio frequency energy, and send the detected data to the core board card through the back plate.

[0066] In an embodiment of the present application, the back plate comprises: a connector female head; the back plate is connected with the connector male head of the core board card, the connector male head of the signal board card and the connector male head of each radio frequency board card through the connector female head.

[0067] In order to better understand the structure of the back plate, refer to Figure 6 for an exemplary preferred structure diagram of the back plate. Figure 6 In the figure, the core board card, the signal board card, the radio frequency board card 1, 2, …, and the radio frequency board card N are respectively connected with the connector female head.

[0068] The preferred connector can be a large-current European DIN heavy load connector. The female connector is a 180° straight pin female seat, and the male connector is a 90° bent pin male seat. The preferred selection of the connector is a single pin 6A, and the test voltage can reach 1550V. The AC / DC power module provides power to each sub-board card through the backplane.

[0069] The above multi-channel radio frequency ablation output system uses the output radio frequency output energy to be in phase with the radio frequency signal generated by the signal board card, which ensures that the final output result is stable and reliable, and the offset between each radio frequency board card does not affect each other. In the single-polarity multi-channel output mode, independent control and monitoring of each radio frequency board card is realized, so that the size of the radio frequency energy of each radio frequency board card can be independently controlled according to the size of each lesion; when facing a larger lesion, multiple channels can work at the same time, and by using the phase in-phase relationship between each other, the ablation range is expanded while the ablation time is shortened. In addition, users can also switch between single-polarity multi-channel output and bipolar single-channel output according to their needs, without manual setting.

[0070] The multi-channel radio frequency ablation output system proposed in the present application overcomes the defect that the traditional multi-channel radio frequency system cannot output radio frequency energy at the same time, can independently output radio frequency energy of each channel, has good independence, and can also independently adjust the radio frequency energy according to needs; can also affect each other through the phase relationship between each radio frequency board card to expand the ablation range while reducing the ablation time, etc., and has excellent practicality.

[0071] Based on the above phase in-phase multi-channel radio frequency ablation output system, the present application also proposes a phase in-phase multi-channel radio frequency ablation output method, which is applied to the phase in-phase multi-channel radio frequency ablation output system described in any one of the above, and includes: First, the power module supplies power to all board cards through the backplane; that is, the entire system is powered on, and the power module supplies power to each board card through the backplane. Then, the core board card is powered on and self-checked, and receives operation instructions after self-checking is normal; that is, the core board enters the operating system, performs initialization processing, and then the core board issues a power-on self-checking instruction, and the entire system starts to detect the connection state and working state of each board card and accessory. After self-checking is normal, the user selects the working mode according to his own needs. The operation instruction includes working mode, selected radio frequency energy output port, output power, power duration and other parameter information.

[0072] The core board card generates information instructions based on the operation instructions and transmits them to the signal board card through the backplane; the signal board card generates initial radio frequency signals based on the information instructions and transmits them to the target radio frequency board card through the backplane. Among them, the preferred way of generating radio frequency signals is slightly different according to the different operation instructions, specifically: If the operation instruction includes: bipolar single output, the required radio frequency energy parameters; the signal board card based on the operation instruction to generate a multi-channel phase coherent radio frequency signal includes: The signal board card switches to bipolar single output using a single bipolar switching module; the signal board card generates a single radio frequency signal with a preset working amplitude and working frequency using a signal generation module according to the required radio frequency energy parameters.

[0073] If the operation instruction includes: unipolar multi-output, the required radio frequency energy parameters; the signal board card based on the operation instruction to generate a multi-channel phase coherent radio frequency signal includes: The signal board card switches to unipolar multi-output using a single bipolar switching module; the signal board card receives the frequency and preset phase threshold in the required radio frequency energy parameters using the MCU in the signal generation module, and then issues an instruction to the DDS chip to generate a multi-channel radio frequency signal and set the phase difference between the radio frequency signals of each radio frequency board card.

[0074] The signal board card uses a phase detection module to detect the phase information of the radio frequency energy output by each radio frequency board card, and determines whether the radio frequency energy output by each radio frequency board card meets the preset phase threshold; if not, the preset phase threshold is adjusted until the adjusted preset phase threshold and the phase difference meet the phase coherent purpose between the radio frequency board cards; if so, the phase coherent purpose between the radio frequency board cards is achieved, the phase value of the corresponding radio frequency signal of each radio frequency board card is locked, and the corresponding multi-channel radio frequency signal is generated.

[0075] After the initial radio frequency signal is generated, the target radio frequency board card amplifies the initial radio frequency signal and transmits it to the signal board card through the backplane. The signal board card uses a single bipolar switching module to convert the single bipolar output of the radio frequency energy according to the selected working mode, and detects the actual parameters of the radio frequency energy to obtain radio frequency energy data and transmits it to the core board card through the backplane.

[0076] The core board card operates the radio frequency energy data to obtain an operation result, and generates a control instruction based on the operation result and transmits it to the signal board card through the backplane; the signal board card adjusts or does not adjust the initial radio frequency signal based on the control instruction, generates a corresponding radio frequency signal and transmits it to the target radio frequency board card through the backplane, which makes the phase shift of each radio frequency board card stable and coherent; while the radio frequency energy is continuously output, the core board card performs periodic self-checking and controls the operation of the multi-channel radio frequency ablation output system according to the results of the periodic self-checking.

[0077] For periodic self-checking, the single bipolar and unipolar working modes are slightly different, specifically: For bipolar single output, the core board card uses the core module to operate the received radio frequency energy data to obtain the power of the radio frequency energy; the core board card uses the temperature detection module to detect the temperature of the energy carrying system, which is cooled by the cooling system circulating the cooling liquid in the energy carrying system to cool it, and the energy carrying system includes the probe.

[0078] The core board card uses the safety warning module to detect the connection of each board card and accessory; if the operation result does not meet the preset power value, the core board card uses the core module to re-operate to generate a new control instruction, so that the power of the radio frequency energy meets the preset power value; if the temperature detection is over standard or a safety warning occurs, the periodic self-check fails, the core board card uses the core module to generate a new control instruction to automatically reduce the output of the radio frequency energy, and determines whether it can pass the periodic self-check again.

[0079] If the periodic self-check still fails, the core board card records the radio frequency energy data and stops working, and enters the power-on self-check state to detect the connection of each board card and each accessory; if the periodic self-check passes, the multi-channel radio frequency ablation output system outputs the radio frequency energy after automatically reducing the radio frequency energy.

[0080] For bipolar single output, the core board card uses the core module to operate the received radio frequency energy data to obtain the power of the radio frequency energy; the core board card uses the temperature detection module to detect the temperature of the energy carrying system, which is cooled by the cooling system circulating the cooling liquid in the energy carrying system to cool it, and the energy carrying system includes the probe.

[0081] The core board card uses the safety warning module to detect the connection of each board card and accessory; if the operation result does not meet the preset power value, the core board card uses the core module to re-operate to generate a new control instruction, so that the power of the radio frequency energy meets the preset power value; if the temperature detection is over standard or a safety warning occurs, the periodic self-check fails, the core board card uses the core module to generate a new control instruction to automatically reduce the output of the radio frequency energy, and determines whether it can pass the periodic self-check again.

[0082] If the self-checking is still not passed, the core board card generates new control instructions with the core module to automatically reduce the output of the radio frequency energy, and determines whether the periodic self-checking can be passed again; if the periodic self-checking is still not passed, the core board card records the radio frequency energy data and stops working, and enters a power-on self-checking state to detect the connection of each board card and each accessory; if the periodic self-checking is passed, the multi-channel radio frequency ablation output system outputs the radio frequency energy after being automatically reduced.

[0083] The multi-channel radio frequency ablation output method described above, in combination with Figure 7 The flowchart shown in the figure is outlined as follows: After the system is powered on, the power module provides working voltage to each board card, and then the core board card is initialized, detects the working state of each board card, judges whether the self-checking of each board card is successful, returns to the previous step if not, and performs system working mode switching according to operation instructions if successful.

[0084] For bipolar single-channel output, the user selects the positive and negative output ports, sets the output power, duration, and the signal board card switches to the bipolar working state, and the system starts working. The radio frequency board card adjusts the output power according to the system settings, and the voltage-current detection module (i.e., the voltage and current feedback network) measures the output power of the system (i.e., the output power of the radio frequency energy) in real time according to the coupled information. At the same time, the system periodically detects the output power of the system, sensor information, and temperature information.

[0085] The system periodically detects the output power of the system, sensor information, and temperature information.

[0086] The system periodically detects the output power of the system, sensor information, and temperature information.

[0087] For single-pole multi-output, set the initial small power, initial phase threshold, duration, signal board card switches to single machine working state, the system starts to work. After that, the core board card controls the DAC to generate multi-channel voltage signal, which is fed back to the power module to generate corresponding multi-channel bus voltage, each voltage is transmitted to the high-power MOS tube on each RF board card as the MOS tube drain voltage; At the same time, the signal board card controls the DDS to generate multi-channel RF signal, and sets the phase difference of each channel, and each channel signal is transmitted to the drive amplifier on each RF board card as the input signal of the drive amplifier.

[0088] Each channel signal (here refers to each channel RF energy) is transmitted to the energy carrying system, the signal board card output end coupler measures the phase information of each channel output RF energy, and the signal board card phase discriminator module compares the collected phase information with the reference signal (i.e. the phase discriminator module discriminates the phase) to determine whether the phase difference of each channel (i.e. each RF board card) is the set threshold.

[0089] If it is not the set threshold, return to the step of setting the initial small power, initial phase threshold, duration, signal board card switches to single machine working state, and the system starts to work; If it is the set threshold, the signal board card phase-locks the RF channel that meets the requirements. The user sets the required power of each channel, the duration of each channel, and other information.

[0090] Each RF board card adjusts the output power of each board card according to the system settings, and the volt-ampere detection module measures the output power of the system in real time according to the coupled information. The system periodically detects the output power, the phase information between each channel, the sensor information, and the temperature information. Then determine whether the system periodic self-check is successful. If it is successful, it is the same as the step of the system periodic self-check successful when the bipolar single-output; If it is not successful, then: First, determine whether the phase information between each channel is normal, if it is not normal, return to the step of setting the initial small power, initial phase threshold, duration, signal board card switches to single machine working state, and the system starts to work; If it is normal, reduce the output power threshold of the RF board card, and determine whether the system periodic self-check is successful again.

[0091] If it is successful, return to the step of each RF board card adjusting the output power of each board card according to the system settings, and the volt-ampere detection module measuring the output power of the system in real time according to the coupled information; If it is not successful, return to the step of the core board card initialization.

[0092] The application is to meet the purpose of multi-channel radio frequency energy output simultaneously, adopts the way of sharing the same system clock, so as to meet the synchronization of the output signals of each channel. Meanwhile, in order to achieve high-precision frequency output and high-precision phase shift offset, the optimal selection is to use 32-bit channel frequency tuning word and 14-bit phase shift offset for each channel. For the output frequency of each channel, Δf=sysclk / 2 32 , when the system clock is 25MHz, Δf≈0.0058Hz, so that the whole system can ensure the frequency output accuracy of each channel with the precision of less than 0.01Hz, and reduce the beat frequency phenomenon caused by the frequency differentiation of each channel. For the phase accuracy of each channel, Δp=360° / 2 14 ≈0.022°, to ensure the phase adjustment accuracy of each channel.

[0093] To generate stable phase shift for each output channel, the application adopts the phase of the radio frequency output energy and the radio frequency signal to ensure that the final output result is stable and reliable, and the offset between channels will not affect each other. Therefore, the core board card in the application obtains the operation result by operating the phase shift between the radio frequency energy and the radio frequency signal, and generates a control instruction, so that the phase shift generated by each radio frequency board card is stable and in phase. That is, the phase shift generated by the signal generating circuit (i.e. the signal board card and the impedance matching board card) and the radio frequency energy amplification circuit (i.e. the radio frequency board card) needs to be calculated. The specific method of operating the phase shift between the radio frequency energy and the radio frequency signal includes: After any radio frequency signal enters the radio frequency board card, the phase shift generated by the radio frequency board card is as follows:

[0094] In the above formula, D represents the duty cycle, represents the susceptance of the parallel capacitor, represents the conductance of the series inductor, represents the delay caused by the Class-E form amplifier, represents the delay caused by the matching network, represents the delay caused by various devices and wiring; In order to ensure high efficiency of the system, the E class amplification mode is adopted. The E class amplifier itself does not produce phase shift, but a load network is needed to introduce an accurate phase delay at a specific frequency to ensure that the field effect transistor is turned on when the voltage is zero. That is, at the moment when the end of the high-power MOS tube is turned on, the voltage across the two terminals must be zero; when it is turned off, the voltage across the two terminals begins to rise. If the above conditions cannot be met, the field effect transistor will have current passing through it at high voltage, resulting in huge switching loss, leading to sharp decline in efficiency and even damage to the device. Therefore, the duty cycle D generated by the present application is 50%, and the phase shift generated by the above formula is -0.5π.

[0095] The output end of the field effect transistor in the radio frequency board card is connected in parallel with a capacitor and in series with an inductor. After normalization, the parallel capacitor and the series inductor are represented by B and G respectively, and the relationship between the parallel capacitor and the series inductor and the load is that the voltage amplitude generated by the parallel capacitor and the series inductor respectively is V R 、 V L respectively as follows:

[0096]

[0097] Under the best matching state of the series inductor and the parallel capacitor, there is the following mathematical relationship:

[0098] The phase shift generated by the radio frequency board card is

[0099] In the above formula, C C represents the capacitance of the parallel capacitor, L L represents the inductance of the series inductor, v V represents the transient voltage in the circuit, I R I represents the load current.

[0100] According to the phase shift formula generated by the radio frequency board card, the phase shift generated by the radio frequency board card is a constant; For the impedance matching circuit, the phase shift generated by the impedance matching circuit is as follows:

[0101] In the above formula, α 0 represents a general constant, equal to , C P C represents the coupling capacitor of the impedance matching circuit, R ​​​L representing the system termination load impedance, R S representing the load impedance of a Class-E form amplifier.

[0102] The phase shift of the impedance matching board card is related to the load, and the phase shift generated by the radio frequency board card is a constant, so the core board card adjusts the phase threshold and phase difference of the multi-path radio frequency signal in real time according to the actual access load. As can be seen from the above formula, since the phase shift of the impedance matching board card is related to the load, each radio frequency energy channel, that is, each radio frequency board card, needs an independent gate driver (that is, a driving amplification circuit), and each gate driver needs independent control of the phase of each channel (that is, independent radio frequency signals) before input. Therefore, during the test process before the system is normally working, the phase output needs to be adjusted in real time according to the actual access load to achieve the best matching state.

[0103] The microstrip line is used to connect between the board cards, and the phase shift generated by the microstrip line As follows:

[0104] Among them,

[0105] In the above, is a value between the dielectric constant of the substrate substrate and the dielectric constant of air 1, λ 0 represents the free space wavelength.

[0106] Because part of the electromagnetic wave propagates in the medium and part of it propagates in the air, is a value between the dielectric constant of the substrate substrate and the dielectric constant of air 1. The value is 4.2, the substrate height is 0.762, and the microstrip line is 2.54mm. Through the above mathematical formula calculation, the microstrip line is about 0.98 meters per phase change 1° at the frequency point of the system working, which can be ignored in actual implementation.

[0107] In addition, since the output of radio frequency energy is generally hundreds of volts, and the signal generating circuit is in the millivolt level, the difference between the same frequency is tens of thousands of times, in order to avoid mutual crosstalk between the same frequency channels and ensure that the radio frequency channel can get good heat dissipation effect, the vertical plug-in architecture is preferably selected. While ensuring portability, each radio frequency path gets good heat dissipation, and good isolation is achieved in terms of circuit and space, avoiding unnecessary self-excitation phenomenon and enhancing the stability of the entire system.

[0108] In summary, the multi-channel radio frequency ablation output system has a system host adopting a VME architecture, and various board cards are tightly coupled and can perform interconnection data processing, and peripheral devices are simple to connect, and each board card can be independently maintained, replaced and upgraded.

[0109] The multi-channel radio frequency ablation output system adopts output radio frequency output energy and radio frequency signals generated by the signal board card to be in phase, so as to ensure that the final output result is stable and reliable, and the offset between the radio frequency board cards does not affect each other. In the single-polarity multi-channel output mode, independent control and monitoring of each radio frequency board card are realized, so that the size of the radio frequency energy of each radio frequency board card can be independently controlled according to the size of each lesion; when facing a larger lesion, multiple channels can work at the same time, and by using the phase-in-phase relationship between each other, the ablation range is expanded while the ablation time is shortened. In addition, the user can also switch between single-polarity multi-channel output and bipolar single-channel output according to the needs, without manual setting.

[0110] The multi-channel radio frequency ablation output system overcomes the defect that the traditional multi-channel radio frequency system cannot output radio frequency energy at the same time, can independently output radio frequency energy of each channel, has good independence, and can also independently adjust the radio frequency energy according to the needs; and can also affect each other through the phase relationship between each radio frequency board card, expand the ablation range while reducing the ablation time, and has excellent practicability.

[0111] Finally, it should be noted that: the above only for the preferred embodiments of the present application, and not for limiting the present application, although the foregoing embodiments of the present application are described in detail, for those skilled in the art, the technical solutions recorded in the foregoing embodiments can be modified, or some technical features can be replaced. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

[0112] It should be noted that each embodiment in the present application is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts of each embodiment can be referred to each other. For the system or device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant part can be referred to the method part.

[0113] The above description of disclosed embodiments allows a skilled person to implement or use the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein can be applied to other embodiments without departing from the spirit or scope of the application. Therefore, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A phase-coherent multi-channel radio frequency ablation output system, characterized in that, include: The system host includes: The backplane is connected to the core board, signal board, and multiple radio frequency boards respectively. The backplane receives the power output from the power module and transmits the power to the components connected to it. The core board interacts with the signal board and multiple radio frequency boards through the backplane, performs calculations based on the interacting data to obtain calculation results, and generates control commands or receives external operation commands based on the calculation results and transmits them to the signal board through the backplane. The signal board generates multi-channel phase-coherent radio frequency signals based on the control command or the operation command and transmits them to the corresponding radio frequency board through the backplane. One radio frequency signal corresponds to one radio frequency board. The signal board can independently turn off and on the radio frequency signals corresponding to each radio frequency board, and adjust the phase information of the radio frequency signals between each radio frequency board according to actual needs. Each RF board uses the bus voltage transmitted from the backplane to amplify the received RF signal to obtain RF energy and transmit it to the signal board through the backplane; and detects the RF energy parameters and transmits them to the core board and the signal board through the backplane. The signal board uses its own monopolar / bipolar switching module to perform monopolar / bipolar conversion of radio frequency energy output according to the selected working mode. The backplane, the core board, the signal board, and the multiple radio frequency boards share the same system clock. The signal board performs a phase-coherent operation on the radio frequency energy and the radio frequency signal, and the control command generated based on the operation result makes the phase shift generated by each radio frequency board stable and phase-coherent. Each RF board uses a 32-bit channel frequency tuning word and a 14-bit phase shift offset, and each RF board has an independent gate driver.

2. The multi-channel radio frequency ablation output system according to claim 1, characterized in that, The core board includes: a core module, a data acquisition card module, and a first connector; The I / O interface, A / D, and D / A of the data acquisition card module are connected to the first connector; The data acquisition card module and the core module interact with each other via a communication port. The acquisition card module is connected to the backplane via the first connector, and interacts with the signal board and multiple radio frequency boards via the backplane. The core module sends analog signals to multiple radio frequency boards through the acquisition card module and the first connector to control the amount of radio frequency energy of each radio frequency board.

3. The multi-channel radio frequency ablation output system according to claim 2, characterized in that, The core board also includes: a temperature detection module and a safety warning module; The A / D and D / A converters of the temperature detection module are connected to the first connector, and are used to detect the probe temperature and feed it back to the acquisition card module. The I / O interface of the safety warning module is connected to the first connector, and it is used to provide warnings for abnormal information based on the instructions of the core module and to provide output protection measures in emergency situations.

4. The multi-channel radio frequency ablation output system according to claim 2, characterized in that, The system host also includes: a display and control interaction module; The display and control interaction module is connected to the core module through a video port and a communication port, respectively. It is used to receive and process the operation instructions and display the target information on the display device. The target information is the data to be displayed received by the core module, as well as the control instructions and the operation instructions.

5. The multi-channel radio frequency ablation output system according to claim 1, characterized in that, The signal board includes: a signal generation module, a second connector, a phase detection module, a single-to-bipolar switching module, a neutral electrode detection module, an impedance switching board, a 9th-order Butterworth low-pass filter, and an optional external REFCLK crystal oscillator; The signal generation module is connected to the backplane via the second connector; The signal generation module includes: an MCU and a DDS chip; The MCU receives the control command or operation command through the backplane, and controls the DDS chip to generate the multi-channel phase-coherent radio frequency signal through the SPI serial port. The number of radio frequency signals is one more than the number of radio frequency boards, and the extra radio frequency signal is used as a phase detection reference signal inside the signal board. The phase detection module is connected to the MCU and the radio frequency energy output port respectively. It is used to receive the phase detection reference signal, obtain the amplitude and phase information of the radio frequency energy and perform phase detection in combination with the phase detection reference signal, and send the phase detection result to the MCU. This allows the MCU to receive the phase detection result at the same time that the DDS chip generates the radio frequency signal. At the same time, according to actual needs, it can autonomously adjust the start / stop, amplitude and phase information of the radio frequency signals between each radio frequency board and periodically report to the core board. The monopolar / bipolar switching module is connected to the radio frequency energy output port and is used to perform monopolar / bipolar conversion of radio frequency energy output according to the selected working mode. The neutral electrode detection module is connected to the radio frequency energy output port and the electrode plate circuit respectively, and is used to monitor the connection between the radio frequency energy output port and the electrode plate circuit; The impedance switching board is located between the output terminal of the radio frequency board and the monopolar / bipolar switching module. It is used to adjust the impedance of the radio frequency energy to match the impedance of the treatment site according to the different impedances of the treatment site. The signal board also includes: a 9th-order Butterworth low-pass filter and an external optional REFCLK crystal oscillator; The output of each of the radio frequency signals is connected in series with the 9th order Butterworth low-pass filter. After being filtered by the 9th order Butterworth low-pass filter, the signal is transmitted to the corresponding radio frequency board through the backplane. When the external optional REFCLK crystal oscillator is selected, the crystal oscillator in the MCU stops working, and the clock of the DDS chip is provided by the external optional REFCLK crystal oscillator.

6. The multi-channel radio frequency ablation output system according to claim 1, characterized in that, Each RF board includes: RF board connector, driver amplifier, field-effect transistor, harmonic network, coupling circuit and voltage and current feedback network; The driver amplifier is connected to the RF board connector and the field-effect transistor respectively. It is used to receive RF signals and analog signals, and amplify the RF signals to generate amplified signals to control the on / off state of the field-effect transistor. The field-effect transistor is connected to the resonant network and is used to generate radio frequency energy with clutter based on the amplified signal and transmit it to the resonant network. The resonant network is connected to the coupling circuit and is used to filter the radio frequency energy with clutter, so as to obtain stable radio frequency energy and transmit it to the coupling circuit. The coupling circuit is connected to the voltage and current feedback network and the signal board respectively, and is used to transmit the stable radio frequency energy to the voltage and current feedback network and the signal board; The voltage and current feedback network includes a voltage coupler, a current coupling circuit, and an operational amplifier circuit. The voltage and current signals are obtained by coupling the stable radio frequency energy using the voltage coupler and the current coupling circuit. The signals are then amplified and isolated by the operational amplifier circuit and transmitted to the core board through the backplane. This allows the core board to perform calculations based on the voltage and current signals to obtain the output power of the radio frequency energy. Each RF board's output is connected to an impedance switching board using an SMA connector. The isolation between adjacent RF boards is >65dB.

7. The multi-channel radio frequency ablation output system according to claim 1, characterized in that, The backplate includes: a female connector head; The backplane is connected to the male connector of the core board, the male connector of the signal board, and the male connector of each RF board via the female connector. The female connector is a 180° straight pin female connector, and the male connector is a 90° bent pin male connector.

8. A phase-coherent multi-channel radio frequency ablation output method, characterized in that, The multi-channel radiofrequency ablation output method is applied to the phase-coherent multi-channel radiofrequency ablation output system according to any one of claims 1-7, and includes: The power module supplies power to all boards via the backplane; After the core board is powered on, it performs a self-test and receives the operation command after the self-test is normal. The core board generates information commands based on the operation instructions and transmits them to the signal board through the backplane. The signal board generates an initial radio frequency signal based on the information command and transmits it to the target radio frequency board through the backplane; The target RF board amplifies the initial RF signal and transmits it to the signal board through the backplane; According to the selected working mode, the signal board uses the single-to-double pole switching module to perform single-to-double pole conversion of radio frequency energy output, and detects the actual parameters of radio frequency energy to obtain radio frequency energy data, which is then transmitted to the core board through the backplane. The core board performs calculations on the radio frequency energy data to obtain the calculation results, and generates the control commands based on the calculation results and transmits them to the signal board through the backplane; The signal board adjusts or does not adjust the initial radio frequency signal based on the control command, generates a corresponding radio frequency signal and transmits it to the target radio frequency board through the backplane. The corresponding radio frequency signal makes the phase shift generated by each radio frequency board stable and coherent. While continuously outputting radio frequency energy, the core board performs periodic self-tests and controls the operation of the multi-channel radio frequency ablation output system based on the results of the periodic self-tests.

9. The multi-channel radio frequency ablation output method according to claim 8, characterized in that, The operation instructions include: bipolar single-channel output and required RF energy parameters; the signal board generates multi-channel phase-coherent RF signals based on the operation instructions, including: The signal board uses the single / dual polarity switching module to switch to bipolar single-channel output; The signal board uses a signal generation module to generate a single-channel radio frequency signal with a working frequency and a preset working amplitude based on the required radio frequency energy parameters.

10. The multi-channel radio frequency ablation output method according to claim 8, characterized in that, The operation instructions include: unipolar multiplexed output and required RF energy parameters; the signal board generates multi-channel phase-coherent RF signals based on the operation instructions, including: The signal board uses the single / dual pole switching module to switch to single-polar multi-channel output; After the signal board receives the frequency and preset phase threshold in the required radio frequency energy parameters from the MCU in the signal generation module, it issues instructions to the DDS chip, which then generates multiple radio frequency signals and sets the phase difference between the radio frequency signals of each radio frequency board. The signal board uses a phase detection module to detect the phase information of the radio frequency energy output by each radio frequency board, and determines whether the radio frequency energy output by each radio frequency board meets the preset phase threshold. If the condition is not met, the preset phase threshold is readjusted until the adjusted preset phase threshold and the phase difference are met, so as to achieve phase coherence between each RF board. If this condition is met, the phase coherence between each RF board is achieved, the phase value of the corresponding RF signal of each RF board is locked, and the corresponding multi-channel RF signal is generated.

11. The multi-channel radio frequency ablation output method according to claim 9, characterized in that, The core board performs periodic self-tests and controls the operation of the multi-channel radiofrequency ablation output system based on the results of these self-tests, including: The core board uses the core module to process the received radio frequency energy data to obtain the power of the radio frequency energy. The core board uses a temperature detection module to detect the temperature of the energy carrying system. The energy carrying system is cooled by a cooling system that circulates coolant within the energy carrying system. The energy carrying system includes a probe. The core board uses a security warning module to detect the connection status of each board and accessory; If the calculation result does not meet the preset power value, the core board uses the core module to recalculate and generate new control instructions so that the power of the radio frequency energy meets the preset power value. If the temperature exceeds the limit or a safety warning is issued, the periodic self-test will fail. The core board will then use the core module to generate new control commands to automatically reduce the output of radio frequency energy and determine whether the periodic self-test can be passed again. If the periodic self-test still fails, the core board records the radio frequency energy data and stops working, and enters the power-on self-test state to check the connection status of each board and accessory; If the periodic self-test passes, the multi-channel radiofrequency ablation output system outputs radiofrequency energy after automatically reducing the radiofrequency energy.

12. The multi-channel radio frequency ablation output method according to claim 10, characterized in that, The core board performs periodic self-tests and controls the operation of the multi-channel radiofrequency ablation output system based on the results of these self-tests, including: The core board uses the core module to process the received radio frequency energy data to obtain the power of the radio frequency energy. The signal board uses a phase detection module to detect the phase coherence between multiple radio frequency boards; The core board uses a temperature detection module to detect the temperature of the energy carrying system. The energy carrying system is cooled by a cooling system that circulates coolant within the energy carrying system. The energy carrying system includes a probe. The core board uses a security warning module to detect the connection status of each board and accessory; If the calculation result does not meet the preset power value, the core board uses the core module to recalculate and generate new control instructions so that the power of the radio frequency energy meets the preset power value. If the temperature exceeds the limit or a safety warning is issued, the periodic self-test will fail. The signal board determines whether the phases of multiple radio frequency boards are coherent. If they are not coherent, the signal board uses the signal generation module to readjust the phase information of the multiple radio frequency signals until the phases of the multiple radio frequency boards are coherent, and determines whether they can pass the periodic self-test again. If the coherent or periodic self-test still fails, the core board uses the core module to generate new control instructions to automatically reduce the output of radio frequency energy and determine whether it can pass the periodic self-test again. If the periodic self-test still fails, the core board records the radio frequency energy data and stops working, and enters the power-on self-test state to check the connection status of each board and accessory; If the periodic self-test passes, the multi-channel radiofrequency ablation output system outputs radiofrequency energy after automatically reducing the radiofrequency energy.

13. The multi-channel radio frequency ablation output method according to claim 8, characterized in that, The core board obtains the calculation result by calculating the phase shift between radio frequency energy and radio frequency signal and generates the control command so that the phase shift generated by each radio frequency board is stable and coherent. The specific methods for calculating the phase shift between radio frequency energy and radio frequency signal include: When any radio frequency signal enters the radio frequency board, the phase shift generated on the radio frequency board... As shown in the following formula: In the above formula, D Indicates duty cycle, The susceptance of a parallel capacitor is represented by its capacitance. This represents the conductance of a series inductor. This indicates the delay caused by the Class-E amplifier. This indicates the delay caused by the matching network. This indicates the delay caused by various devices and wiring; The output terminal of the field-effect transistor on the RF board is connected in parallel with a capacitor and in series with an inductor. After normalizing both, let B and G represent the relationship between the parallel capacitor and the series inductor and the load, respectively. Then, the voltage amplitude generated on the parallel capacitor and the series inductor is... V R , V L They are represented as follows: Under the optimal matching condition of series inductor and parallel capacitor, the following mathematical relationship holds: Phase shift generated by RF board for: In the above formula, C This indicates the capacitance value of the parallel capacitors. L This indicates the inductance value of the series inductor. v Represents the transient voltage in the circuit. I R Indicates the load current; The phase shift generated by the RF board can be determined from the formula. It is a constant; For impedance matching circuits, the resulting phase shift as follows: In the above formula, α 0 represents a general constant, equal to , C P This represents the coupling capacitor in the impedance matching circuit. R L Indicates the system termination load impedance. R S This indicates the load impedance of a Class-E amplifier; The phase shift of the impedance matching board is related to the load, and the phase shift generated by the RF board is a constant. Therefore, the core board adjusts the phase threshold and phase difference of the multiple RF signals in real time according to the actual connected load. When the various boards are connected using microstrip lines, the phase shift generated by the microstrip lines... As shown in the following formula: in, In the above formula, It is between the dielectric constant of the substrate and the dielectric constant of the substrate. The value between and the dielectric constant of air, 1, λ 0 represents the wavelength in free space.

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