Anti-hair loss microemulsion, anti-hair loss shampoo and application
By combining cationic emulsifiers, nonionic emulsifiers, and synergists, an anti-hair loss microemulsion is formed, which solves the problem of easy washing away of traditional Chinese medicine ingredients and achieves long-lasting and effective anti-hair loss and dandruff removal effects, suitable for hair loss driven by multiple factors.
Patent Information
- Application Number
- CN202511346810.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-19
- Publication Date
- 2026-02-24
AI Technical Summary
There is a lack of long-lasting and effective Chinese herbal anti-hair loss shampoos on the market, and existing Chinese herbal ingredients are easily washed away, resulting in unsatisfactory anti-hair loss effects, high costs, and inconvenience for consumers.
A combination of cationic emulsifiers, nonionic emulsifiers, and synergists is used to form an anti-hair loss microemulsion containing extracts of Platycladus orientalis leaves, processed Polygonum multiflorum, and Astragalus membranaceus. Through electrostatic interactions, physical adsorption, and hydrophobic interactions, the active ingredients are enhanced to improve their adsorption performance on the scalp and hair, and a cross-linked network structure is constructed to enhance the anti-hair loss and dandruff removal effects.
It achieves synergistic effects across multiple pathways and targets, significantly improving the utilization rate and retention of active ingredients, effectively preventing hair loss and removing dandruff, and is suitable for hair loss types driven by multiple factors, including androgenetic alopecia and seborrheic alopecia.
Smart Images
Figure CN121550059A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of cosmetic technology, specifically to an anti-hair loss microemulsion, an anti-hair loss shampoo, and their applications. Background Technology
[0002] As more and more people experience hair loss, the demand for anti-hair loss shampoos is increasing. However, there are not many truly effective and long-lasting herbal anti-hair loss shampoos on the market.
[0003] As shampoo products, many traditional Chinese medicine ingredients effective in preventing hair loss are washed away by water during use, making it difficult for them to remain on the hair and scalp. Therefore, while many traditional Chinese medicine ingredients have good anti-hair loss effects, they can only be used in products with residue, such as serums. These products require long-term, continuous use, which doesn't align with most consumers' habits and is difficult to maintain, resulting in less than ideal anti-hair loss effects. Furthermore, current traditional Chinese medicine anti-hair loss shampoos contain high levels of herbal extracts, leading to high costs.
[0004] Therefore, this application is submitted. Summary of the Invention
[0005] The purpose of this application is to overcome the shortcomings of the existing technology and provide an anti-hair loss microemulsion, an anti-hair loss shampoo and its application, wherein the anti-hair loss microemulsion has excellent anti-hair loss and dandruff removal effects.
[0006] To achieve the above objectives, the first aspect of this application provides an anti-hair loss microemulsion comprising the following components in parts by weight: 0.1 to 5 parts cationic emulsifier, 0.5 to 5 parts Platycladus orientalis leaf extract, 0.5 to 5 parts anti-hair loss composition, 1 to 40 parts nonionic emulsifier, 10 to 40 parts synergist, and 39.5 to 53.4 parts water;
[0007] The anti-hair loss composition comprises processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract in a mass ratio of 1:(0.5-7):(0.5-7);
[0008] The synergist includes at least one of hydrogenated polyisobutylene, hydrogenated polydecene, hydrogenated didecene, neopentyl glycol diheptanoate, propylene glycol diheptanoate, and undecenoate heptyl ester.
[0009] As an embodiment of this application, it includes the following components in parts by weight: 1-2 parts cationic emulsifier, 2-3 parts Platycladus orientalis leaf extract, 2-3 parts anti-hair loss composition, 8-20 parts nonionic emulsifier, 25-35 parts synergist and 48-51 parts water.
[0010] As an embodiment of this application, the anti-hair loss composition comprises processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract in a mass ratio of 1:(2-3):(1-2).
[0011] As an embodiment of this application, the synergist comprises hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(1 to 1.5).
[0012] As an embodiment of this application, the mass ratio of the arborvitae leaf extract to the anti-hair loss composition is 1:(1.5-3).
[0013] As an embodiment of this application, the cationic emulsifier includes at least one of palmitamidopropyltrimethylammonium chloride, hymediamine chloride, alkyltrimethylammonium chloride, and undecenoamitamidopropyltrimethylammonium methyl sulfate.
[0014] As an embodiment of this application, the nonionic emulsifier includes at least one of PEG-7 glyceryl cocoate, di(PPG-2 myristyl alcohol polyether-10) adipate, di(PPG-3 myristyl ether) adipate, polyglycerol-4 lauryl ester, PEG-6 caprylic / capric glycerides, and lauryl alcohol polyether-4.
[0015] As an embodiment of this application, the nonionic emulsifier comprises PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate in a mass ratio of (1 to 1.5):1.
[0016] As an embodiment of this application, the Coix seed extract is obtained by supercritical extraction of Coix seed powder, wherein the entrainer for supercritical extraction is an ethanol solution and the extractant for supercritical extraction is CO2.
[0017] As an embodiment of this application, the supercritical extraction uses a 60-75 wt% ethanol solution as an entrainer and CO2 as the extractant, with a CO2 flow rate of 80-120 mL / min.
[0018] As an embodiment of this application, the extraction temperature is 35-40℃, the extraction pressure is 28-30 MPa, and the extraction time is 60-180 min.
[0019] A second aspect of this application provides the application of the described anti-hair loss microemulsion in the preparation of cosmetics.
[0020] As an embodiment of this application, the anti-hair loss microemulsion has a mass percentage content of 0.01-10% in the cosmetic.
[0021] As an embodiment of this application, the anti-hair loss microemulsion has a mass percentage content of 0.1% to 5% in cosmetics.
[0022] A third aspect of this application provides a method for preparing an anti-hair loss microemulsion, comprising the following steps:
[0023] (1) Mix the processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract evenly to obtain the anti-hair loss composition;
[0024] (2) Mix some water, cationic emulsifier and nonionic emulsifier until homogeneous;
[0025] (3) Add the synergist, arborvitae leaf extract and anti-hair loss composition to step (2), stir evenly, then add the remaining water and stir evenly to obtain anti-hair loss microemulsion.
[0026] In step (2), some of the water accounts for 20-60% of the total water mass.
[0027] In step (2), the stirring rate is 100-400 rpm and the time is 10-60 min.
[0028] In step (3), the stirring speed is 100-400 rpm and the time is 10-60 min.
[0029] The fourth aspect of this application provides an anti-hair loss shampoo comprising the following components in weight percentages: 12-20% anionic surfactant, 6-10% amphoteric surfactant, 1.5-6% nonionic surfactant, 0.2-0.8% preservative, 0.2-1% solubilizer, 0.2-0.8% pH adjuster, 0.1-0.5% cationic surfactant, 0.01-10% anti-hair loss microemulsion, and 60-75% water;
[0030] The anti-hair loss microemulsion is the anti-hair loss microemulsion described above.
[0031] The beneficial effects of this application are as follows: The anti-hair loss microemulsion described in this application can effectively achieve synergistic effects through multiple pathways and multiple targets, such as inhibiting 5α-reductase activity, protecting hair follicles from free radical damage, improving the scalp microenvironment, promoting blood circulation and proliferation of hair follicles, soothing scalp inflammation, and strengthening the scalp barrier function. The synergist, nonionic emulsifier, and cationic emulsifier can effectively improve the adsorption performance of active ingredients (Thuja orientalis leaf extract and anti-hair loss composition) on the scalp and hair. The anti-hair loss microemulsion has a comprehensive and efficient anti-hair loss effect and is suitable for hair loss types driven by multiple factors, such as androgenetic alopecia and seborrheic alopecia. At the same time, it can effectively inhibit Malassezia and effectively remove dandruff while preventing hair loss. Attached Figure Description
[0032] Figure 1 The anti-shedding microemulsion prepared in Example 1.
[0033] Figure 2 The test shampoo prepared in Example 1.
[0034] Figure 3This is a picture of the volunteer's hair before use in Example 1.
[0035] Figure 4 This is a picture of the hair of a volunteer after using it in Example 1. Detailed Implementation
[0036] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0037] In this application, the technical features described in an open-ended manner include both closed technical solutions consisting of the listed features and open technical solutions that include the listed features.
[0038] In this application, numerical ranges are referred to as continuous unless otherwise specified, and include the minimum and maximum values of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.
[0039] In this application, there are no particular restrictions on the specific dispersion and mixing methods.
[0040] Unless otherwise specified, all components, raw materials, or instruments used in the embodiments and comparative examples of this application are commercially available, and the components and raw materials used in each parallel experiment are the same.
[0041] This application provides an anti-hair loss microemulsion, comprising the following components in parts by weight: 0.1 to 5 parts cationic emulsifier, 0.5 to 5 parts Platycladus orientalis leaf extract, 0.5 to 5 parts anti-hair loss composition, 1 to 40 parts nonionic emulsifier, 10 to 40 parts synergist and 39.5 to 53.4 parts water;
[0042] The anti-hair loss composition comprises processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract in a mass ratio of 1:(0.5-7):(0.5-7);
[0043] The synergist includes at least one of hydrogenated polyisobutylene, hydrogenated polydecene, hydrogenated didecene, neopentyl glycol diheptanoate, propylene glycol diheptanoate, and undecenoate heptyl ester.
[0044] This application combines the above-mentioned raw materials in specific mass proportions, allowing the components to interact and cooperate to effectively achieve synergistic effects through multiple pathways and targets, including inhibiting 5α-reductase activity, protecting hair follicles from free radical damage, improving the scalp microenvironment, promoting blood circulation and proliferation in hair follicles, soothing scalp inflammation, and strengthening the scalp barrier function. The synergist, nonionic emulsifier, and cationic emulsifier effectively enhance the adsorption performance of the active ingredients (Thuja orientalis leaf extract and anti-hair loss composition) on the scalp and hair. The anti-hair loss microemulsion has a comprehensive and highly effective anti-hair loss effect, suitable for multi-factor driven hair loss types such as androgenetic alopecia and seborrheic alopecia, while also effectively inhibiting Malassezia and effectively removing dandruff while preventing hair loss.
[0045] The cationic emulsifier significantly enhances the adsorption efficiency of active ingredients on the scalp and hair through electrostatic interaction, while the nonionic emulsifier reduces surface tension, improves the spreadability and wettability of active ingredients, allowing for more even distribution and fuller contact with the scalp and hair. The synergist adsorbs onto the hair and scalp surface through physical adsorption and hydrophobic interactions, forming a continuous, thin, hydrophobic oil film. This film extends the retention time of active ingredients through a physical barrier effect and assists in their dispersion, improving transdermal absorption. The synergist and cationic emulsifier together reduce the rinsing loss rate of active ingredients. The synergist, nonionic emulsifier, and cationic emulsifier construct a cross-linked network structure on the hair and scalp, effectively improving emulsification and dispersion of active ingredients. This significantly enhances the adsorption performance of the active ingredients (Thuja orientalis leaf extract and anti-hair loss composition) on the scalp and hair, significantly improving their utilization and retention, and significantly enhancing their anti-hair loss and dandruff-removing effects.
[0046] The efficacy of the components of the extract is as follows: The Platycladus orientalis leaf extract is rich in pinoresinol diglucoside, flavonoids (such as quercetin), volatile oils (containing α-pinene, β-pinene, etc.), polysaccharides, and other active ingredients. It can effectively inhibit 5α-reductase activity, reduce the conversion of testosterone to dihydrotestosterone (DHT), effectively inhibit hair-pathogenic bacteria (Malassezia, Staphylococcus aureus), improve the scalp microenvironment, dilate scalp capillaries, increase blood flow to hair follicles, and effectively promote blood circulation in hair follicles. The processed Polygonum multiflorum extract is rich in stilbene glycosides, anthraquinone compounds, and flavonoids. It can activate hair follicle stem cells, promote cell proliferation, and propel hair follicles from the resting phase to the growth phase. It effectively regulates the hair follicle growth cycle, protects hair follicles from free radical damage, balances hair follicle miniaturization caused by excess androgens, and inhibits androgenetic alopecia. The Coix Seed Extract effectively regulates the scalp microecology, inhibits the growth of pathogens, promotes the growth of beneficial bacteria, effectively soothes scalp inflammation, stimulates keratinocyte proliferation, accelerates the repair of damaged barriers, reduces transepidermal water loss, and provides a stable and healthy growth environment for hair follicles. The Astragalus Root Extract activates hair follicle cells, promotes hair growth, and alleviates hair loss caused by seborrheic dermatitis, folliculitis, etc. In addition to the above-mentioned effects, there are still unpredictable synergistic or antagonistic effects between the components. Based on the specific emulsification system and specific mass ratio of this application, a multi-pathway and multi-target synergistic effect is achieved to enhance efficacy, effectively removing dandruff while preventing hair loss.
[0047] In some embodiments, the components include the following parts by weight: 1-2 parts cationic emulsifier, 2-3 parts Platycladus orientalis leaf extract, 2-3 parts anti-hair loss composition, 8-20 parts nonionic emulsifier, 25-35 parts synergist, and 48-51 parts water. In particular, when the parts by weight of each raw material are within this range, the overall compatibility of the formulation is better, and it has a more ideal synergistic effect, which can further improve the utilization rate of active ingredients and further improve the anti-hair loss and dandruff removal effects.
[0048] In some embodiments, the anti-hair loss composition includes processed Polygonum multiflorum extract, Coix seed extract, and Astragalus membranaceus extract in a mass ratio of 1:(2-3):(1-2). In particular, when the mass ratio of processed Polygonum multiflorum extract, Coix seed extract, and Astragalus membranaceus extract is within this range, the content of active ingredients in each oil-controlling pathway is not too low, the compatibility between the components is better, and the anti-hair loss and dandruff removal effects are more effectively improved.
[0049] In some embodiments, the synergist comprises hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(1-1.5). During actual research and development, the applicant discovered that when a synergist composed of hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(0.5-2) is used, the synergist can form a uniform and durable film on the hair surface, effectively reducing the loss of moisture and nutrients from the hair, helping to maintain the stability of the active ingredients on the hair, and prolonging the action time of the active ingredients. Simultaneously, the synergist can promote the uniform distribution and adhesion of cationic emulsifiers on the hair. The cationic emulsifier provides charge neutralization and adsorption sites, with hydrogenated polyisobutylene and hydrogenated polydecene filling the spaces between them, and can enhance the adhesion and spreading of nonionic emulsifiers on the hair. The lipophilic ends of the cationic emulsifier and the lipophilic ends of the nonionic emulsifier penetrate deep into the mixed phase of hydrogenated polyisobutylene and hydrogenated polydecene, working together to enable the active ingredients to be better adsorbed and adhered to the hair and scalp, effectively improving the anti-hair loss and dandruff removal effects.
[0050] As an embodiment of this application, the mass ratio of the arborvitae leaf extract to the anti-hair loss composition is 1:(1.5-3). When the mass ratio of the arborvitae leaf extract to the anti-hair loss composition is within this range, the anti-hair loss and dandruff removal effect can be further improved.
[0051] As an embodiment of this application, the cationic emulsifier includes at least one of palmitamidopropyltrimethylammonium chloride, hymediamine chloride, alkyltrimethylammonium chloride, and undecenoamitamidopropyltrimethylammonium methyl sulfate.
[0052] In some embodiments, the nonionic emulsifier includes at least one of PEG-7 glyceryl cocoate, di(PPG-2 myristyl alcohol polyether-10) adipate, di(PPG-3 myristyl ether) adipate, polyglycerol-4 lauryl ester, PEG-6 caprylic / capric glycerides, and lauryl alcohol polyether-4.
[0053] In some embodiments, the nonionic emulsifier comprises PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate in a mass ratio of (1 to 1.5):1.
[0054] In some embodiments, the Coix seed extract is obtained by supercritical extraction of Coix seed powder, wherein the entrainer for supercritical extraction is an ethanol solution and the extractant for supercritical extraction is CO2.
[0055] This application obtains a Coix seed extract with excellent anti-hair loss and anti-dandruff effects by supercritical extraction of Coix seeds. The Coix seed extract can effectively regulate the scalp microecology, inhibit the growth of pathogens, promote the growth of beneficial bacteria, effectively soothe scalp inflammation, stimulate the proliferation of keratinocytes, accelerate the repair of damaged barriers, reduce transepidermal water loss, and provide a stable and healthy growth environment for hair follicles.
[0056] In some embodiments, the supercritical extraction uses a 60-75 wt% ethanol solution as an entrainer and CO2 as the extractant, with a CO2 flow rate of 80-120 mL / min.
[0057] In some embodiments, the extraction temperature is 35-40°C, the extraction pressure is 28-30 MPa, and the extraction time is 60-180 min. This application uses low-temperature and high-pressure extraction parameters, which can help avoid the damage of heat-sensitive components to high temperatures, while promoting the complete preservation of active substances such as linoleic acid, linolenic acid, and coixol in Coix seed, thereby further improving the anti-hair loss and dandruff removal effect.
[0058] One embodiment of this application provides the application of the aforementioned anti-hair loss microemulsion in the preparation of cosmetics.
[0059] In some embodiments, the anti-hair loss microemulsion has a mass percentage content of 0.01 to 10% in the cosmetic.
[0060] In some embodiments, the anti-hair loss microemulsion has a mass percentage content of 0.1% to 5% in the cosmetic.
[0061] One embodiment of this application provides an anti-hair loss shampoo comprising the following components by weight percentage: 12-20% anionic surfactant, 6-10% amphoteric surfactant, 1.5-6% nonionic surfactant, 0.2-0.8% preservative, 0.2-1% solubilizer, 0.2-0.8% pH adjuster, 0.1-0.5% cationic surfactant, 0.01-10% anti-hair loss microemulsion, and 60-75% water;
[0062] The anti-hair loss microemulsion is the anti-hair loss microemulsion described above.
[0063] In some embodiments, the anionic surfactant includes at least one of sodium lauryl ether sulfate, sodium lauryl sulfate, sodium alkylbenzene sulfonate, and sodium alkyl polyoxyethylene ether sulfate.
[0064] In some embodiments, the zwitterionic surfactant includes at least one of cocamidopropyl betaine, cocamidomethyl MEA, and lauryl hydroxysulfonate betaine.
[0065] In some embodiments, the nonionic surfactant includes at least one of ethylene glycol distearate, fatty alcohol polyoxyethylene ether, and alkylphenol polyoxyethylene ether.
[0066] In some embodiments, the preservative includes at least one of methylparaben, ethylparaben, and phenoxyethanol.
[0067] In some embodiments, the solubilizer comprises hydrogenated castor oil.
[0068] In some embodiments, the pH adjuster includes at least one of citric acid, lactic acid, sodium hydroxide, and triethanolamine.
[0069] In some embodiments, the cationic surfactant includes guar hydroxypropyltrimethylammonium chloride.
[0070] In some embodiments, the anti-hair loss shampoo comprises the following components in weight percentages: 12-20% sodium lauryl ether sulfate, 6-10% cocamidopropyl betaine, 1-4% cocamidomethyl MEA, 0.5-2% ethylene glycol distearate, 0.2-0.8% preservative, 0.2-1% hydrogenated castor oil, 0.2-0.8% citric acid, 0.1-0.5% guar hydroxypropyltrimethylammonium chloride, 0.01-10% anti-hair loss microemulsion, and 60-75% water.
[0071] The raw materials used in the examples and comparative examples are as follows:
[0072] Palmitamide propyltrimethylammonium chloride: sourced from Evonik Industries.
[0073] Arborvitae leaf extract: sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0074] Polygonum multiflorum extract: sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0075] Astragalus membranaceus extract: sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0076] Sophora flavescens extract: sourced from Shanghai Aoli Industrial Co., Ltd.
[0077] Phyllanthus emblica extract: sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0078] Astragalus extract: sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0079] Extract of *Hanmolian* (a type of lotus) is sourced from Shanghai Songhao Biotechnology Co., Ltd.
[0080] Hydrogenated polyisobutylene: sourced from Croda Chemicals (Shanghai) Co., Ltd.
[0081] Hydrogenated polydecene: derived from ExxonMobil.
[0082] Neopentyl glycol diheptanoate: sourced from Cidols, Malaysia.
[0083] Propylene glycol diheptane ester: sourced from Cidols, Malaysia.
[0084] PEG-7 glyceryl cocoate: sourced from Croda Chemicals (Shanghai) Co., Ltd.
[0085] Di(PPG-2 Myristyl Alcohol Polyether-10) Adipate: Sourced from Croda Chemicals (Shanghai) Co., Ltd.
[0086] Isohexadecane: derived from Hatsumitsu, Japan.
[0087] The preparation method of Coix Seed Extract-1 is as follows: Coix seeds are pulverized to 100 mesh to obtain Coix Seed Powder. Coix seeds are added to an extraction vessel and subjected to supercritical extraction to obtain the extract. The extract is then dried to obtain Coix Seed Extract. The supercritical extraction uses CO2 as the extractant, 75wt% ethanol as the entrainer, CO2 flow rate is 80mL / min, extraction temperature is 35℃, extraction pressure is 28MPa, and extraction time is 100min.
[0088] The preparation method of Coix Seed Extract-2 is as follows: Coix seeds are pulverized to 100 mesh to obtain Coix seed powder. Coix seeds are added to an extraction vessel and subjected to supercritical extraction to obtain the extract. The extract is then dried to obtain Coix Seed Extract. The supercritical extraction uses CO2 as the extractant, 60wt% ethanol as the entrainer, CO2 flow rate is 120mL / min, extraction temperature is 40℃, extraction pressure is 30MPa, and extraction time is 100min.
[0089] The preparation method of Coix Seed Extract-3 is as follows: The preparation method of Coix Seed Extract in this embodiment is as follows: Coix seeds are pulverized to 100 mesh to obtain Coix Seed Powder. Coix seeds are added to an extraction vessel and subjected to supercritical extraction to obtain the extract. The extract is then dried to obtain Coix Seed Extract. The supercritical extraction uses CO2 as the extractant, 75wt% ethanol as the entrainer, CO2 flow rate is 80mL / min, extraction temperature is 50℃, extraction pressure is 20MPa, and extraction time is 100min.
[0090] The preparation method of Coix Seed Extract-4 is as follows: The preparation method of Coix Seed Extract in this embodiment is as follows: Coix seeds are pulverized to 100 mesh to obtain Coix Seed Powder. Coix seeds are added to an ethanol aqueous solution with a volume fraction of 70% (8 times their weight) and extracted at 60°C for 30 min. Subsequently, extraction is carried out at an ultrasonic power of 280W and a temperature of 60°C for 1 h. After extraction, the mixture is filtered, the extract is collected, and dried to obtain Coix Seed Extract.
[0091] The following embodiments are provided to facilitate understanding of this application. These embodiments are provided not to limit the scope of the claims.
[0092] Example 1
[0093] A method for preparing an anti-hair loss microemulsion includes the following steps:
[0094] (1) Mix Polygonum multiflorum extract, Coix seed extract-1 and Astragalus membranaceus extract evenly to obtain an anti-hair loss composition;
[0095] (2) Mix a portion of water (40% of the total water mass), palmitamide propyltrimethylammonium chloride, PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate at 25°C and 200 rpm for 30 min.
[0096] (3) Add hydrogenated polyisobutylene, hydrogenated polydecene, arborvitae leaf extract and anti-hair loss composition to step (2), stir at 200 rpm for 30 min, then add the remaining water, stir at 400 rpm for 1 h to obtain anti-hair loss microemulsion.
[0097] The proportions of each raw material are shown in Table 1.
[0098] The actual image of the anti-hair loss microemulsion in Example 1 is shown below. Figure 1 As shown.
[0099] Examples 2-4
[0100] The difference between Examples 2 to 4 and Example 1 is that the amount of each raw material is changed, as shown in Table 1.
[0101] Examples 5-7
[0102] The difference between Examples 5-7 and Example 2 is that the amounts of Polygonum multiflorum extract, Coix seed extract, and Astragalus membranaceus extract were changed, as shown in Table 1.
[0103] Examples 8-10
[0104] Examples 8-10 differ from Example 2 in that the amounts of Platycladus orientalis leaf extract, processed Polygonum multiflorum extract, Coix seed extract, and Astragalus membranaceus extract are varied, as shown in Table 1.
[0105] Examples 11-13
[0106] The difference between Examples 11-13 and Example 2 is that the amount of hydrogenated polyisobutylene and hydrogenated polydecene added is changed, as shown in Table 1.
[0107] Examples 14-17
[0108] The difference between Examples 14-17 and Example 2 is that the selection of synergists is different, as shown in Table 2.
[0109] The synergist in Example 14 is a single hydrogenated polyisobutylene.
[0110] The synergist in Example 15 is a single hydrogenated polydecene.
[0111] The synergist in Example 16 is a single neopentyl glycol diheptyl ester.
[0112] The synergist in Example 17 is a single propylene glycol diheptanoate.
[0113] Examples 18-19
[0114] The difference between Examples 18 and 19 and Example 2 is that the cationic emulsifier is selected differently.
[0115] The cationic emulsifier in Example 18 was hymexazol.
[0116] The cationic emulsifier in Example 19 is undecenoamamidopropyltrimethylammonium methyl sulfate.
[0117] Examples 20-22
[0118] Examples 20-22 differ from Example 2 in that the amounts of PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate are changed, as shown in Table 2.
[0119] Example 23
[0120] The difference between Example 23 and Example 2 is that the nonionic emulsifier is selected differently.
[0121] The nonionic emulsifier in Example 23 is polyglycerol-4 laurate.
[0122] Example 24
[0123] Example 24 differs from Example 2 in that an equal amount of Coix Seed Extract-2 is used to replace Coix Seed Extract-1, while all other aspects remain the same.
[0124] Example 25
[0125] Example 25 differs from Example 2 in that an equal amount of Coix Seed Extract-3 is used to replace Coix Seed Extract-1, while all other aspects remain the same.
[0126] Example 26
[0127] Example 26 differs from Example 2 in that an equal amount of Coix Seed Extract-4 is used to replace Coix Seed Extract-1, while all other aspects remain the same.
[0128] Comparative Example 1
[0129] The difference between Comparative Example 1 and Example 2 is that the anti-hair loss composition of Comparative Example 1 is a single processed Polygonum multiflorum extract.
[0130] Comparative Example 2
[0131] The difference between Comparative Example 1 and Example 2 is that the anti-hair loss composition of Comparative Example 2 is a single Coix seed extract.
[0132] Comparative Example 3
[0133] The difference between Comparative Example 3 and Example 2 is that the anti-hair loss composition of Comparative Example 3 is a single Astragalus membranaceus extract.
[0134] Comparative Example 4
[0135] The difference between Comparative Example 4 and Example 2 is that the anti-hair loss composition of Comparative Example 4 lacks Astragalus membranaceus extract (total amount remains the same).
[0136] Comparative Example 5
[0137] The difference between Comparative Example 5 and Example 2 is that the anti-hair loss composition of Comparative Example 6 lacks Polygonum multiflorum extract (total amount remains the same).
[0138] Comparative Example 6
[0139] The difference between Comparative Example 6 and Example 2 is that the anti-hair loss composition of Comparative Example 4 lacks Coix seed extract (total amount remains the same).
[0140] Comparative Example 7
[0141] The difference between Comparative Example 7 and Example 2 is that Comparative Example 7 does not contain Platycladus orientalis leaf extract.
[0142] Comparative Example 8
[0143] The difference between Comparative Example 8 and Example 2 is that Comparative Example 8 does not contain an anti-hair loss composition.
[0144] Comparative Example 9
[0145] The difference between Comparative Example 9 and Example 2 is that Comparative Example 9 uses an equal amount of Sophora flavescens extract to replace Platycladus orientalis leaf extract.
[0146] Comparative Example 10
[0147] The difference between Comparative Example 10 and Example 2 is that Comparative Example 10 uses equal amounts of Phyllanthus emblica extract and Astragalus membranaceus extract to replace Coix lacryma-jobi extract and Astragalus membranaceus extract.
[0148] Comparative Example 11
[0149] The difference between Comparative Example 11 and Example 2 is that Comparative Example 11 uses equal amounts of Sophora flavescens extract and Astragalus membranaceus extract to replace Polygonum multiflorum extract and Astragalus membranaceus extract.
[0150] Comparative Example 12
[0151] The difference between Comparative Example 12 and Example 2 is that Comparative Example 12 uses equal amounts of Phyllanthus emblica extract and Echinopsis pilosula extract to replace Polygonum multiflorum extract and Coix lacryma-jobi extract.
[0152] Comparative Examples 13-14
[0153] The difference between Comparative Examples 13 and 14 and Example 2 is that the amounts of Polygonum multiflorum extract, Coix seed extract, and Astragalus membranaceus extract were changed, as shown in Table 3.
[0154] Comparative Example 15
[0155] The difference between Comparative Example 15 and Example 2 is that Comparative Example 15 uses equal amounts of isohexadecane to replace hydrogenated polyisobutylene and hydrogenated polydecene.
[0156] Table 1 (All figures in the table are parts by weight)
[0157]
[0158]
[0159] Table 2 (All figures in the table are parts by weight)
[0160]
[0161]
[0162] Table 3 (All figures in the table are parts by weight)
[0163]
[0164] Performance testing
[0165] I. To investigate the anti-hair loss composition and Platycladus orientalis leaf extract on the anti-hair loss microemulsion, the following tests were conducted on Examples 1-10, Examples 24-26, and Comparative Examples 1-14:
[0166] 1. The anti-hair loss microemulsion was subjected to an inhibition test against Malassezia furfur (ATCC 44344) according to the "QBT 2738-2012(7.3) - Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products".
[0167] 2. Anti-hair loss efficacy test
[0168] The CCK-8 assay was used to evaluate the promoting effect of the samples on the proliferation of human dermal papilla cells. The specific steps are as follows: human dermal papilla cells were divided into groups of 1×10⁻⁶ cells. 6 Human dermal papilla cells were seeded at a density of 10 cells / well in 96-well plates (referred to as the experimental group) and incubated overnight in a (37°C, CO2) incubator. When the cell seeding rate reached 50%, DMEM high-glucose medium containing 100 μL of anti-shedding microemulsion was added to the 96-well plates. DMEM high-glucose medium without anti-shedding microemulsion was used as the control group. Each group had at least 3 replicates. The cells were incubated at 37°C for 48 h. The relative cell viability (%) of human dermal papilla cells was detected by the CCK-8 assay.
[0169] Relative cell activity (%) = 100% * (OD value of experimental group - OD value of control group) / OD value of control group.
[0170] Table 4
[0171]
[0172]
[0173] II. To further investigate the anti-hair loss effect of the anti-hair loss composition and Platycladus orientalis leaf extract on the anti-hair loss microemulsion, and to investigate the effects of cationic emulsifiers, nonionic emulsifiers, and synergists on the anti-hair loss effect of the composition, the following experiments were conducted:
[0174] 1. Anti-hair loss volunteer test
[0175] 1.1 Preparation of the test shampoo: The following components were weighed according to the formula (the amount of anti-hair loss microemulsion in each example and comparative example was 1%): sodium lauryl ether sulfate 16%, cocamidopropyl betaine 8%, cocamidomethyl MEA 2%, ethylene glycol distearate 1%, phenoxyethanol 0.6%, hydrogenated castor oil 0.4%, citric acid 0.4%, guar hydroxypropyltrimethylammonium chloride 0.3%, anti-hair loss microemulsion 1%, and water as the balance.
[0176] Preparation of the test shampoo: Guar gum hydroxypropyltrimethylammonium chloride was added to water and dispersed evenly. Citric acid was then added and stirred evenly. Sodium lauryl ether sulfate, cocamidopropyl betaine, cocamidomethyl MEA, ethylene glycol distearate, and hydrogenated castor oil were added in sequence. The mixture was heated to 90 degrees Celsius and stirred evenly. The temperature was then lowered to 45 degrees Celsius, and anti-hair loss microemulsion was added and stirred evenly to obtain the test shampoo.
[0177] Among them, the test shampoo prepared using the anti-hair loss microemulsion of Example 1 is as follows: Figure 2 As shown.
[0178] 1.2 Volunteer selection: 205 volunteers with hair loss were selected and randomly divided into 41 groups of 5 people each. The volunteers in each group used the test shampoo of the example and the comparative example.
[0179] 1.3 The inclusion criteria for volunteers were: female aged 20-30 years; no use of hormone drugs or immunosuppressants in the past month; no participation in other clinical trials at the test site in the present or in the past 30 days; able to cooperate well with the trial; able to read and understand all the contents of the informed consent form and voluntarily sign the informed consent form; and agree not to use any cosmetics, drugs, or health products that may affect the results during the trial.
[0180] Criteria for termination and withdrawal: failure to use the test sample as required or failure to keep follow-up records during the trial; serious illness or serious adverse reaction during the use of the sample.
[0181] 1.4 Test method: Volunteers washed their hair once a day and massaged it for 5 minutes each time. After two months of continuous use, the number of hairs lost was recorded. The effect of the volunteers' use was observed and statistically analyzed, and the rate of decrease in the number of hairs lost was recorded.
[0182] The rate of decrease in the number of hair roots is calculated as follows: 100% * (number of hairs lost on day 0 - number of hairs lost in 2 months) / number of hairs lost on day 0, where the number of hairs lost in 2 months represents the number of hairs lost on the day the 2-month test was completed.
[0183] One of the volunteers in Example 1 had their hair before and after the treatment, as shown in the following image. Figures 3-4 As shown.
[0184] Table 5
[0185]
[0186]
[0187] As can be seen from Tables 4 and 5, the anti-hair loss microemulsion described in this application has excellent anti-hair loss and dandruff removal effects.
[0188] Comparing Example 2 with Comparative Examples 1-6 and 9-12, it can be seen that the processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract described in this application have a significant synergistic effect in preventing and removing dandruff. Under the synergistic effect of the three, the anti-hair loss and dandruff removal effect of the composition is significantly improved. The absence of one of them or the replacement of the components in the composition with other ingredients will result in a significant decrease in the anti-hair loss and dandruff removal effect.
[0189] Comparing Example 2 with Comparative Examples 7-8, it can be seen that the reason why the anti-hair loss microemulsion described in this application has excellent anti-hair loss and dandruff removal effects is that it contains both Platycladus orientalis leaf extract and anti-hair loss composition. The addition of both is a necessary component for this application to achieve anti-hair loss and dandruff removal.
[0190] Comparative Examples 2 and 13-14 show that this application significantly improves the anti-hair loss and dandruff removal effect by controlling the mass ratio of Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract to 1:(0.5-7):(0.5-7).
[0191] Comparing Example 2 with Comparative Example 15, it can be seen that the synergist described in this application can significantly improve the anti-hair loss and dandruff removal effect.
[0192] Comparative Examples 1-4 show that by controlling the amount of each raw material to be: 1-2 parts cationic emulsifier, 2-3 parts arborvitae leaf extract, 2-3 parts anti-hair loss composition, 8-20 parts nonionic emulsifier, 25-35 parts synergist and 48-51 parts water, the anti-hair loss and dandruff removal effect of the composition can be further improved.
[0193] Comparing Examples 2 and 5 with Examples 6 and 7, it can be seen that this application further improves the anti-dandruff and dandruff-removing effect by controlling the mass ratio of Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract to 1:(2-3):(1-2).
[0194] Comparing Examples 2 and 8 with Examples 9 and 10, it can be seen that this application further improves the anti-hair loss and dandruff removal effect by controlling the mass ratio of Platycladus orientalis leaf extract and anti-hair loss composition to 1:(1.5-3).
[0195] Comparing Examples 2 and 24 with Examples 25 and 26, it can be seen that the Coix seed extract prepared by the preparation method of this application can further improve the anti-hair loss and dandruff removal effect.
[0196] Comparing Examples 2 and 11 with Examples 12 to 17, it can be seen that by using a synergist of hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(1 to 1.5), the anti-hair loss effect can be further improved.
[0197] Comparing Example 2 with Examples 18-19, it can be seen that by using palmitamide propyltrimethylammonium chloride as a cationic emulsifier, the anti-hair loss effect can be further improved.
[0198] Comparing Examples 2 and 20 with Examples 21 to 23, it can be seen that by using PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate in a mass ratio of (1 to 1.5):1, the anti-hair loss effect can be further improved.
[0199] III. Stability Testing
[0200] 1. Preparation of the test shampoo: Weigh the following components according to the formula (the amount of anti-hair loss microemulsion in each example and comparative example is 1%): sodium lauryl ether sulfate 16%, cocamidopropyl betaine 8%, cocamidomethyl MEA 2%, ethylene glycol distearate 1%, phenoxyethanol 0.6%, hydrogenated castor oil 0.4%, citric acid 0.4%, guar hydroxypropyltrimethylammonium chloride 0.3%, anti-hair loss microemulsion 1%, and water as the balance.
[0201] Preparation of the test shampoo: Guar gum hydroxypropyltrimethylammonium chloride was added to water and dispersed evenly. Citric acid was then added and stirred evenly. Sodium lauryl ether sulfate, cocamidopropyl betaine, cocamidomethyl MEA, ethylene glycol distearate, and hydrogenated castor oil were added in sequence. The mixture was heated to 90 degrees Celsius and stirred evenly. The temperature was then lowered to 45 degrees Celsius, and anti-hair loss microemulsion was added and stirred evenly to obtain the test shampoo.
[0202] 2. Weigh out nine 25g samples (3*3) of each test shampoo into transparent PET bottles and place them at constant temperatures of -18℃, 25℃, and 48℃ for 90 days. After returning to room temperature, observe their stability. The rating test results are shown in the table below. The criteria for judging stability are that the sample does not show any layering or oil seepage after returning to room temperature, and the transparency does not change. Otherwise, it is considered abnormal. Record the number of days that stability problems occur. If there is no abnormality after 90 days, record it as no abnormality.
[0203] Table 6
[0204]
[0205]
[0206] As can be seen from Table 1, the anti-hair loss microemulsion described in this application has excellent stability. It does not exhibit stability problems at room temperature; it does not exhibit stability problems for at least 88 days at -18℃; and it does not exhibit stability problems for at least 80 days at 48℃.
[0207] By comparing Examples 2 and 14-17, it can be seen that this application further improves stability by using hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(1-1.5) as synergists. No stability problems occur under cold, hot and room temperature conditions for 90 days.
[0208] By comparing Examples 2, 20-22 with Example 23, it can be seen that the present application uses PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate in a mass ratio of (1-1.5):1 as nonionic emulsifiers, which further improves the stability of the anti-hair loss microemulsion.
[0209] By comparing Example 2 and Comparative Example 13, it can be seen that the synergist described in this application can significantly improve the stability of the anti-hair loss microemulsion.
[0210] IV. Patch Test
[0211] 1. Test substance: The anti-hair loss microemulsion prepared in the examples and comparative examples.
[0212] 2. Blank control: distilled water.
[0213] 3. Subjects: Twenty healthy subjects aged 20-30 years with no history of skin diseases or allergies were selected. The anti-hair loss microemulsion was used for a human skin patch test. Each subject's arm was divided into 40 patch test areas (20 areas on the left arm and 20 areas on the right arm, each patch test area was 1cm*1cm, and each patch test area did not affect each other). Patch tests were performed on each subject's patch test areas for the example, comparative example, and blank control.
[0214] 4. Patch Test Method: Using qualified patch test equipment, a closed patch test method was employed. 0.020–0.025 g of the test substance was placed inside the patch tester, and the outside of the device was covered with hypoallergenic adhesive tape and applied to the subject's arm. The test substance was removed after 24 hours, and skin reactions were observed 24 hours later. The results were recorded according to the skin reaction grading standards in the *Cosmetic Safety Technical Specifications* (2015 edition). The scores are shown in Table 7.
[0215] Table 7
[0216]
[0217] After patch testing, no adverse skin reactions were observed in the examples and comparative examples, and all were negative reactions (0), indicating that the anti-hair loss microemulsion of this application has good safety and is mild and non-irritating.
[0218] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.
Claims
1. A microemulsion for preventing hair loss, characterized in that, The product comprises the following components in parts by weight: 0.1 to 5 parts cationic emulsifier, 0.5 to 5 parts Platycladus orientalis leaf extract, 0.5 to 5 parts anti-hair loss composition, 1 to 40 parts nonionic emulsifier, 10 to 40 parts synergist and 39.5 to 53.4 parts water; The anti-hair loss composition comprises processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract in a mass ratio of 1:(0.5-7):(0.5-7); The synergist includes at least one of hydrogenated polyisobutylene, hydrogenated polydecene, hydrogenated didecene, neopentyl glycol diheptanoate, propylene glycol diheptanoate, and undecenoate heptyl ester.
2. The anti-hair loss microemulsion according to claim 1, characterized in that, The product comprises the following components in parts by weight: 1-2 parts cationic emulsifier, 2-3 parts Platycladus orientalis leaf extract, 2-3 parts anti-hair loss composition, 8-20 parts nonionic emulsifier, 25-35 parts synergist and 48-51 parts water.
3. The anti-hair loss microemulsion according to claim 1, characterized in that, The anti-hair loss composition comprises processed Polygonum multiflorum extract, Coix seed extract and Astragalus membranaceus extract in a mass ratio of 1:(2-3):(1-2).
4. The anti-hair loss microemulsion according to claim 1, characterized in that, The synergist comprises hydrogenated polyisobutylene and hydrogenated polydecene in a mass ratio of 1:(1 to 1.5).
5. The anti-hair loss microemulsion according to claim 1, characterized in that, The mass ratio of the arborvitae leaf extract to the anti-hair loss composition is 1:(1.5-3).
6. The anti-hair loss microemulsion according to claim 1, characterized in that, The cationic emulsifier includes at least one of palmitamidopropyltrimethylammonium chloride, hymediamine chloride, alkyltrimethylammonium chloride, and undecenoamitamidopropyltrimethylammonium methyl sulfate.
7. The anti-hair loss microemulsion according to claim 1, characterized in that, The nonionic emulsifier includes at least one of PEG-7 glyceryl cocoate, di(PPG-2 myristyl alcohol polyether-10) adipate, di(PPG-3 myristyl ether) adipate, polyglycerol-4 lauryl ester, PEG-6 caprylic / capric glycerides, and lauryl alcohol polyether-4.
8. The anti-hair loss microemulsion according to claim 7, characterized in that, The nonionic emulsifier comprises PEG-7 glyceryl cocoate and di(PPG-2 myristyl alcohol polyether-10) adipate in a mass ratio of (1 to 1.5):
1.
9. The anti-hair loss microemulsion according to claim 1, characterized in that, The Coix Seed Extract is obtained by supercritical extraction of Coix Seed Powder, wherein the entrainer for supercritical extraction is an ethanol solution and the extractant for supercritical extraction is CO2.
10. The anti-hair loss microemulsion according to claim 9, characterized in that, The supercritical extraction uses a 60-75 wt% ethanol solution as an entrainer and CO2 as the extractant, with a CO2 flow rate of 80-120 mL / min.
11. The anti-hair loss microemulsion according to claim 9, characterized in that, The extraction temperature is 35–40℃, the extraction pressure is 28–30 MPa, and the extraction time is 60–180 min.
12. The use of the anti-hair loss microemulsion according to any one of claims 1 to 11 in the preparation of cosmetics.
13. The application according to claim 12, characterized in that, The anti-hair loss microemulsion has a mass percentage content of 0.01-10% in the cosmetic.
14. The application according to claim 12, characterized in that, The anti-hair loss microemulsion has a mass percentage content of 0.1% to 5% in the cosmetic.
15. An anti-hair loss shampoo, characterized in that, It comprises the following components by weight percentage: 12–20% anionic surfactant, 6–10% amphoteric surfactant, 1.5–6% nonionic surfactant, 0.2–0.8% preservative, 0.2–1% solubilizer, 0.2–0.8% pH adjuster, 0.1–0.5% cationic surfactant, 0.01–10% anti-shedding microemulsion, and 60–75% water; The anti-hair loss microemulsion is the anti-hair loss microemulsion according to any one of claims 1 to 11.