Bionic skin conductive material and preparation method and application thereof

Abstract

The invention relates to a biomimetic material, in particular to a biomimetic skin conductive material and a preparation method and application thereof, and the biomimetic skin conductive material comprises a substrate layer and a nanofiber membrane formed on the substrate layer through electrostatic spinning; the nanofiber membrane is composed of nanoscale fibers and a conductive material loaded on the surfaces of the fibers; wherein the fiber is a polymer fiber, and the conductive material is one or more of a polymer material, a carbon material, a metal and a metal oxide; the nanofiber membrane has an extracellular matrix structure. Compared with the prior art, the method solves the problem that in the prior art, a fiber membrane prepared through electrostatic spinning still has a certain difference with real skin performance, and the requirements for high bionic performance and high simulation are difficult to meet. According to the scheme, the shape control of the prepared nanofiber membrane is realized through blending electrostatic spinning, and the conductivity and the air permeability of the nanofiber membrane are adjusted.

Description

Technical Field

[0001] This invention relates to a biomimetic material, specifically to a biomimetic skin conductive material and its preparation method and application. Background Technology

[0002] The skin is the largest organ in the human body and a vital barrier protecting us from external threats. It not only prevents the invasion of bacteria, viruses, and other microorganisms, but also plays a crucial role in regulating the endocrine system. When the structural integrity of the skin is disrupted (e.g., due to trauma, burns, congenital skin abnormalities, diabetic foot ulcers), timely wound repair is essential to maintain the body's internal environmental balance.

[0003] However, skin self-renewal is slow. When the area of ​​skin to be renewed is too large or there is a chronic wound, it is difficult to achieve healing through skin self-renewal alone, often requiring long-term and advanced medical intervention. This is because skin has a certain degree of conductivity (its conductivity is 10⁻⁶ under direct current or low-frequency alternating current conditions). -4 ~10 -2 S·m -1 Conductive biomimetic skin generates an endogenous electric field at the defect site, thus enhancing wound healing efficiency through external electrical stimulation. However, the mechanisms underlying wound healing due to variations in its structure and conductivity remain unclear. Therefore, it holds great potential for research into constructing conductive biomimetic skin to simulate real skin and conduct wound healing studies under various conditions and environments, as well as for its application in preparing wound dressings to further simulate and test the electric field patterns on the skin surface, and for the efficient treatment of skin injuries.

[0004] Electrospinning is a simple and easy-to-implement technique that can produce fibers with diameters ranging from nanometers to micrometers. Electrospinned fiber membranes have attracted widespread attention due to their high porosity, good air permeability, moisture permeability, large specific surface area, and suitable mechanical strength.

[0005] CN112981556B discloses an electrospinning fiber collecting device and a method for preparing radially oriented nanofiber membranes. The device includes a ring electrode, a circular electrode, and a support; the inner diameter of the ring electrode is larger than the diameter of the circular electrode; both the circular and ring electrodes are on the same plane, with the circular electrode fixed at the center of the ring electrode, forming an electrode plane; both the ring and circular electrodes are fixed on the support. The method includes: placing the electrode plane perpendicular to a needle, connecting a power source, extruding the electrospinning solution from the needle, performing electrospinning treatment, and drying to obtain a nanofiber membrane. Although this technology develops a method for preparing radially oriented nanofiber membranes using ring and circular electrodes, for conductive materials, the high conductivity of the solution often prevents the formation of stable Taylor cones and fiber breakage, making the solution unspinnable.

[0006] CN108998892A discloses a method for preparing a chitosan-graphene oxide / polyacrylonitrile bilayer nanofiber membrane. The method first prepares a graphene oxide dispersion, then dissolves polyacrylonitrile in the dispersion and mixes them uniformly to obtain a graphene oxide / polyacrylonitrile electrospinning solution. Chitosan and polyethylene oxide are then dissolved in formic acid solution and mixed uniformly to prepare a chitosan electrospinning solution. Subsequently, a graphene oxide / polyacrylonitrile nanofiber membrane is prepared by electrospinning using the graphene oxide / polyacrylonitrile electrospinning solution. Finally, the chitosan electrospinning solution is used to electrospin on the surface of the graphene oxide / polyacrylonitrile nanofibers to obtain the chitosan-graphene oxide / polyacrylonitrile bilayer nanofiber membrane. The bilayer nanofiber membrane obtained by this method improves the mechanical properties of the polyacrylonitrile nanofiber membrane. However, the interlayer adhesion of the bilayer structure is often insufficient, leading to easy delamination of the material, and the bonding sites often have high interfacial impedance, making it difficult to form a conductive nanofiber membrane with uniform conductivity.

[0007] Therefore, it is necessary to develop a new material that can be used as biomimetic skin through electrospinning, so as to provide a highly realistic material for research on skin dressings, wound electrical stimulation healing, etc. Summary of the Invention

[0008] The purpose of this invention is to address at least one of the aforementioned problems by providing a biomimetic skin-conductive material, its preparation method, and its application. This addresses the issue that existing electrospinning-based fiber membranes still exhibit certain differences in properties compared to real skin, making it difficult to meet the demands for high biomimicry and realism. This solution achieves morphological control of the nanofiber membrane through blended electrospinning, and adjusts its conductivity and breathability.

[0009] The objective of this invention is achieved through the following technical solution: The first aspect of the present invention discloses a biomimetic skin conductive material, comprising a base layer and a nanofiber membrane formed on the base layer by electrospinning. The nanofiber membrane is composed of nanoscale fibers and a conductive material loaded on the surface of the fibers; wherein the fibers are polymer fibers and the conductive material is one or more of polymer materials, carbon materials, metals and metal oxides. The nanofiber membrane has an extracellular matrix structure.

[0010] Preferably, in the nanofiber membrane, the fibers are arranged in a randomly packed structure; or, The fibers are oriented fibers or coaxial fibers.

[0011] Preferably, the material of the fiber, It is one or more of polyethylene oxide, polylactic acid, polyvinylidene fluoride, polyvinyl alcohol, polyethylene glycol, polycaprolactone, polyglycolic acid, polyvinylpyrrolidone, and polylactic-co-hydroxyacetic acid copolymer.

[0012] Preferably, the material of the conductive material is... The polymer material is one or more of polyaniline, polypyrrole, and poly(3,4-ethylenedioxythiophene). Carbon materials are carbon nanotubes and / or graphene-like materials. The metal and metal oxide are one or more of gold, silver, copper, and indium tin oxide.

[0013] Preferably, the fiber is made of polyethylene oxide, and the material is made of polyaniline.

[0014] A second aspect of this invention discloses a method for preparing a biomimetic skin conductive material as described in any of the above descriptions, comprising the following steps: S1: Add the fiber raw material to an organic solvent to prepare a fiber solution; S2: Add conductive material raw materials to the fiber solution prepared in step S1, stir evenly, and prepare an electrospinning solution; S3: The electrospinning solution prepared in step S2 is deposited on the surface of the substrate layer by electrospinning to form a nanofiber membrane; S4: Dry the substrate layer with nanofiber membrane formed by electrospinning in step S3 to obtain the biomimetic skin conductive material. Alternatively, it may include the following steps: T1: Add fiber raw materials to an organic solvent to prepare an electrospinning solution; T2: The electrospinning solution prepared in step T1 is deposited on the surface of the substrate layer by electrospinning to form a nanofiber membrane; T3: The conductive material raw material is added to the solvent and ultrasonically treated to form a conductive dispersion; T4: The conductive dispersion formed in step T3 is ultrasonically coated onto the surface of the nanofiber membrane formed in step T2 to obtain the biomimetic skin conductive material.

[0015] Preferably, in step S1, the organic solvent, It is one or both of chloroform and N,N-dimethylformamide; In step T1, the organic solvent, It is hexafluoroisopropanol; In step T3, the solvent includes inorganic or organic solvents. Specifically, it can be deionized water.

[0016] Preferably, in step S2, the electrospinning solution, The mass percentage of fiber raw material used is 3 wt%; The mass fraction of the conductive material raw material is 12~20 wt%; In step T1, the electrospinning solution, The mass of fiber raw material used is 1 g per 5 mL; In step T3, the conductive dispersion, The mass fraction of the conductive material raw material is 1.3 wt%.

[0017] Preferably, in step S3, the electrospinning... The voltage is 15~20kV; The syringe pump delivers the solution at a rate of 0.8~1 mL / h. -1 ; In step T2, the electrospinning, The voltage is 15~20kV; The syringe pump delivers the solution at a rate of 0.8~1 mL / h. -1 .

[0018] The third aspect of the present invention discloses the application of the biomimetic skin conductive material as described above in the preparation of wound dressings or biomimetic skin.

[0019] The working principle of this invention is as follows: By combining polymer materials with conductive materials using electrospinning technology, and by adjusting the concentration of the electrospinning solution, voltage, and the speed at which the solution is propelled by the injection pump to control the fiber morphology and properties, it is possible to prepare uniform composite fiber membranes by utilizing the synergistic effect at the molecular level of polymer materials and conductive materials with different properties, thus overcoming the technical defects of single-component materials.

[0020] Compared with the prior art, the present invention has the following beneficial effects: 1) This invention uses materials with different properties to give electrospun nanofiber membranes different morphologies and high porosity, good air permeability and moisture permeability.

[0021] 2) The biomimetic skin conductive material prepared by electrospinning in this invention has both appropriate mechanical strength and conductivity, as well as a skin-like ECM structure, which makes the biomimetic skin conductive material have a highly realistic and biomimetic effect, and can be used in research on wound electrical stimulation healing, etc.

[0022] 3) The biomimetic skin conductive material prepared by electrospinning in this invention can not only serve as a temporary barrier as a skin substitute, but also accelerate the self-regeneration and repair process of human skin, and can be used as a dressing for skin wounds.

[0023] 4) The electrospinning technology used in this invention has the advantages of simple and mature process, diverse material selection, low cost and high practicality. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the apparatus used for electrospinning.

[0025] Figure 2 This is a schematic diagram of the structure of a biomimetic skin-conductive material.

[0026] Figure 3 Scanning electron microscope image of the biomimetic skin conductive material prepared in Example 1.

[0027] Figure 4 This is a schematic diagram of the electric field distribution of the biomimetic skin conductive material prepared in Example 2 under DC voltage conditions.

[0028] Figure 5 The results of the water vapor transmission rate test of the biomimetic skin conductive material prepared in Example 1 are shown.

[0029] In the diagram: 1-Receiver; 2-Propulsion device; 3-High voltage power supply; 4-Taylor cone; 5-Base layer; 6-Electrospinning solution; 7-Fiber; 8-Conductive material. Detailed Implementation

[0030] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0031] Unless otherwise specified, the reagents used in the following description are commercially available products, the methods used are known in the art, and all other matters not covered herein are common knowledge.

[0032] Nanofiber membranes prepared by electrospinning have a microstructure similar to that of the natural extracellular matrix, which can improve hemostasis and promote cell proliferation, adhesion, and migration. Furthermore, nanofiber membranes can serve as carriers for the controlled delivery and release of biomolecules and drugs. They can be formed by electrospinning a mixture of polymers and conductive materials, and their conductivity can be tunable through post-treatments such as ultrasonic coating and spraying.

[0033] This invention controls the morphology of nanofiber membranes to form a skin-like extracellular matrix (ECM) structure through blending electrospinning and post-processing methods such as ultrasonic coating and spraying, and adjusts their conductivity and breathability. Taking skin wound dressings as an example, it mainly utilizes the mixing of polymer fibers and conductive materials to prepare different nanofiber membranes (e.g., random stacking, oriented fibers, coaxial fibers, etc.) through electrospinning technology to prepare high-performance conductive biomimetic skin wound dressings.

[0034] The materials used in the electrospinning of this invention include, but are not limited to, polymers and mixtures thereof such as polyethylene oxide (PEO), polylactic acid (PLA), polyvinylidene fluoride (PVDF), polyvinyl alcohol (PVA), polyethylene glycol (PEG), polycaprolactone (PCL), polyglycolic acid (PGA), polyvinylpyrrolidone (PVP), and polylactic acid-glycolic acid copolymer (PLGA); the conductive materials are polymers such as polyaniline (PANI), polypyrrole (PPy), and poly(3,4-ethylenedioxythiophene) (PEDOT), carbon materials such as carbon nanotubes (CNT) and graphene, and metals or metal oxides such as gold, silver, copper, and indium tin oxide (ITO); thereby giving the wound dressing good biocompatibility and wound healing-promoting activity.

[0035] Figure 1 This is a schematic diagram of the electrospinning device used for preparing skin wound dressings in this scheme. The base layer 5 is covered on the receiver 1 (including but not limited to flat plates, rollers, conductive cloth, mesh, etc.). The electrospinning solution 6 is extruded under the action of the propulsion device 2 and stretched to form a Taylor cone 4 under the high voltage direct current generated by the high voltage power supply 3. Finally, due to bending instability, the jet falls onto the base layer 5 to form a nanofiber membrane for skin wound dressings.

[0036] Figure 2 This is a schematic diagram of the nanofiber membrane formation in this invention. The polymer fibers 7 in the electrospinning solution 6... Figure 1 Under the action of the device shown, the fiber elongates and thins to form a uniform fiber 7 with a diameter of nanometers. At the same time, conductive material 8 is attached to the fiber 7 and deposited together on the substrate layer 5 to form a conductive nanofiber membrane.

[0037] Given that the technology of this invention can be applied to a wide range of materials and has broad application scenarios, the following detailed description is provided in conjunction with specific embodiments. It should be noted that the embodiments described below are merely provided to facilitate understanding of this solution by those skilled in the art and are not intended to limit the scope of this solution; in addition to the combinations used in the following embodiments, this solution can be arbitrarily selected and combined within the aforementioned range.

[0038] Example 1 A solution of chloroform (CHCl3) and N,N-dimethylformamide (DMF) with a molar ratio of 5:1 was prepared. 3 wt% polyethylene oxide (PEO) was added to the mixed solution to prepare a PEO polymer solution. Polyaniline (PANI) was then added at a mass ratio of 15 wt%, and the mixture was magnetically stirred for 12 h to obtain a PANI / PEO spinning solution. Figure 1 The method uses a voltage of 15 kV and a solution propagation rate of 1 mL / h using a syringe pump. -1Electrospinning was performed to obtain a randomly stacked nanofiber membrane. The obtained nanofiber membrane was dried and then sterilized to obtain artificial skin.

[0039] Measurements using a four-probe tester showed that the average conductivity of the artificial skin in Example 1 of this invention was 6.43 × 10⁻⁶. -3 S·m -1 This indicates that the artificial skin is conductive and its conductivity is consistent with that of human skin.

[0040] Figure 3 This is a scanning electron microscope image of Embodiment 1 of the present invention. From... Figure 3 As can be seen, the PEO fibers are freely arranged, and the conductive polymer PANI is dispersed and attached to the fibers in a granular form. Moreover, because the fiber material is nanoscale, the conductive PANI can be interconnected, resulting in good conductivity.

[0041] Figure 5 Table 1 shows the water vapor transmission rate (WVTRate) test results of the biomimetic skin conductive material prepared in Example 1 of this invention. The test method involved adding 1 mL of deionized water to multiple 2 mL centrifuge tubes. The biomimetic skin conductive material prepared in Example 1 was cut to a certain size and adhered with double-sided tape to completely cover the opening of the 2 mL centrifuge tubes. The material was weighed using an analytical balance, and the initial weight W0 was recorded. The centrifuge tubes covered with the biomimetic skin conductive material were placed in a constant temperature and humidity test chamber (temperature set at 37 ℃, humidity at 35%). Samples were removed and weighed at different time points, and the weight was recorded as W0. t Because the water vapor barrier properties of the test materials are typically unstable at the initial stage of testing, and considering that the samples in this test were all polymers, which have a certain adsorption effect on water vapor, data were measured at five time points: 3 h, 6 h, 9 h, 12 h, and 24 h. The water vapor permeability of injured human skin is 279~5138 g / (m²). 2 ·d), the ideal water vapor transmission rate of wound dressing is 2500 g / (m³). 2 ·d). From Figure 5 As can be seen from this, the water vapor transmission rate of this embodiment is all around 2500 g / (m²). 2 The evaporation rate is around d), which is within the range of normal human skin evaporation. Moreover, the measurement results of multiple parallel experiments (sample 1-sample 4) are basically the same, indicating that this biomimetic skin conductive material has good moisture permeability.

[0042] Table 1. Water vapor transmission rate (WVT Rate) test results of the biomimetic skin conductive material prepared in Example 1 Example 2 A solution of chloroform (CHCl3) and N,N-dimethylformamide (DMF) with a molar ratio of 5:1 was prepared. 3 wt% polyethylene oxide (PEO) and 15 wt% polyaniline (PANI) were then added to the mixed solution to obtain a PANI / PEO spinning solution. Figure 1 The method is based on a drum speed of 1000 r·min -1 The voltage is 15 kV, and the solution propulsion rate of the syringe pump is 1 mL·h. -1 Electrospinning was performed to obtain an oriented nanofiber membrane. The obtained nanofiber membrane was dried and then sterilized to obtain artificial skin.

[0043] Figure 4 This is a schematic diagram of the electric field distribution under DC voltage conditions in Embodiment 2 of the present invention. The left figure shows the experimental verification conditions, while the middle and right figures show the results of multiple experimental verifications. It can be seen from the figures that under the conditions of a constant voltage of 5 volts and a constant current of 1 amp, the artificial skin exhibits an electric field distribution that conforms to physical laws.

[0044] Example 3 A solution of chloroform (CHCl3) and N,N-dimethylformamide (DMF) with a molar ratio of 5:1 was prepared. 3 wt% polyethylene oxide (PEO) was added to the mixed solution to prepare a PEO polymer solution. Polyaniline (PANI) was added at a mass ratio of 12 wt%. The mixture was magnetically stirred for 12 h to obtain a PANI / PEO spinning solution.

[0045] according to Figure 1 The method involves a voltage of 20 kV and a solution delivery rate of 0.8 mL / h using a syringe pump. -1 Electrospinning was performed to obtain a randomly stacked nanofiber membrane. The obtained nanofiber membrane was dried and then sterilized to obtain artificial skin.

[0046] Example 4 A solution of chloroform (CHCl3) and N,N-dimethylformamide (DMF) with a molar ratio of 5:1 was prepared. 3 wt% polyethylene oxide (PEO) was added to the mixed solution to prepare a PEO polymer solution. Polyaniline (PANI) was added at a mass ratio of 20 wt%. The mixture was magnetically stirred for 12 h to obtain a PANI / PEO spinning solution.

[0047] according to Figure 1 The method involves a voltage of 20 kV and a solution delivery rate of 0.8 mL / h using a syringe pump. -1 Electrospinning was performed to obtain a randomly stacked nanofiber membrane. The obtained nanofiber membrane was dried and then sterilized to obtain artificial skin.

[0048] Example 5 1.0 g of polylactic acid (PLLA) was added to 5 mL of hexafluoroisopropanol (HFIP) and magnetically stirred for 12 h at room temperature to prepare a PLLA electrospinning solution. Figure 1 The method involves a voltage of 15 kV and a solution delivery rate of 1.0 mL / h using a syringe pump. -1 Electrospinning was performed to obtain a randomly stacked nanofiber membrane, which was then dried in a drying oven for 24 hours.

[0049] 1.0 mL of a 13 wt% CNT solution was added to 9 mL of deionized water and sonicated for 10 min to obtain a uniform 1.3 wt% CNT dispersion (i.e., diluted 10 times, with concentrations relative to the dispersion). PLLA / CNT nanofiber membranes were prepared using an ultrasonic coating method. Pure PLLA nanofiber membranes were cut into 2 cm × 2 cm pieces and placed in a petri dish. 1.0 mL of CNT dispersion was added dropwise to the petri dish to immerse the PLLA nanofiber membrane. The petri dish was then placed in an ultrasonic stirrer and treated at room temperature for 10 min. After removing excess solution, the membrane was dried in a 35 ℃ oven to obtain the PLLA / CNT nanofiber membrane.

[0050] Comparative Example 1 This comparative example is essentially the same as Example 1, except that the polyaniline content is 5 wt%, resulting in a PANI / PEO nanofiber membrane. Measurements using a four-probe tester showed that this PANI / PEO nanofiber membrane is non-conductive.

[0051] Comparative Example 2 This comparative example is basically the same as Example 1, the only difference being that the polyaniline content is 30wt%, resulting in an electrospinning solution that is too viscous to be spun according to the formula. Figure 1 Electrospinning is performed using this method.

[0052] In summary, this invention controls the morphology, conductivity, breathability, and skin-like ECM structure of nanofiber membranes through blending electrospinning and post-processing methods such as ultrasonic coating and spraying. This technology is of paramount importance for shaping the appearance and properties of electrospun fiber membranes. This invention shows broad application potential in fields such as biomimetic skin and wound dressings. Furthermore, the preparation process of this invention is based on current simple and mature production technologies, offering not only low cost but also a wide range of raw material options, providing significant prospects for large-scale production and industrialization. The biomimetic skin-conductive material manufactured by this invention demonstrates enormous application potential in skin tissue engineering, wound dressings, and surgical wound repair.

[0053] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A biomimetic skin-conductive material, characterized in that, Includes a substrate layer (5) and a nanofiber membrane formed on the substrate layer (5) by electrospinning; The nanofiber membrane is composed of nanoscale fibers (7) and conductive material (8) loaded on the surface of the fibers (7); wherein the fibers (7) are polymer fibers and the conductive material (8) is one or more of polymer materials, carbon materials, metals and metal oxides. The nanofiber membrane has an extracellular matrix structure.

2. The biomimetic skin conductive material according to claim 1, characterized in that, In the nanofiber membrane, the fibers (7) are arranged in a random stacked structure; or, The fiber (7) is an oriented fiber or a coaxial fiber.

3. The biomimetic skin conductive material according to claim 1, characterized in that, The material of the fiber (7) mentioned above, It is one or more of polyethylene oxide, polylactic acid, polyvinylidene fluoride, polyvinyl alcohol, polyethylene glycol, polycaprolactone, polyglycolic acid, polyvinylpyrrolidone, and polylactic-co-hydroxyacetic acid copolymer.

4. The biomimetic skin conductive material according to claim 1, characterized in that, The material of the conductive material (8) is... The polymer material is one or more of polyaniline, polypyrrole, and poly(3,4-ethylenedioxythiophene). Carbon materials are carbon nanotubes and / or graphene-like materials. The metal and metal oxide are one or more of gold, silver, copper, and indium tin oxide.

5. The biomimetic skin conductive material according to claim 1, characterized in that, The fiber (7) is made of polyethylene oxide, and the material (8) is made of polyaniline.

6. A method for preparing a biomimetic skin conductive material as described in any one of claims 1 to 5, characterized in that, Includes the following steps: S1: Add the fiber raw material to an organic solvent to prepare a fiber solution; S2: Add conductive material raw materials to the fiber solution prepared in step S1, stir evenly, and prepare an electrospinning solution; S3: The electrospinning solution prepared in step S2 is deposited on the surface of the substrate layer by electrospinning to form a nanofiber membrane; S4: Dry the substrate layer with nanofiber membrane formed by electrospinning in step S3 to obtain the biomimetic skin conductive material. Alternatively, it may include the following steps: T1: Add fiber raw materials to an organic solvent to prepare an electrospinning solution; T2: The electrospinning solution prepared in step T1 is deposited on the surface of the substrate layer by electrospinning to form a nanofiber membrane; T3: The conductive material raw material is added to the solvent and ultrasonically treated to form a conductive dispersion; T4: The conductive dispersion formed in step T3 is ultrasonically coated onto the surface of the nanofiber membrane formed in step T2 to obtain the biomimetic skin conductive material.

7. The method for preparing a biomimetic skin conductive material according to claim 6, characterized in that, In step S1, the organic solvent, It is one or both of chloroform and N,N-dimethylformamide; In step T1, the organic solvent, It is hexafluoroisopropanol; In step T3, the solvent, It is deionized water.

8. The method for preparing a biomimetic skin conductive material according to claim 6, characterized in that, In step S2, the electrospinning solution, The mass percentage of fiber raw material used is 3 wt%; The mass fraction of the conductive material raw material is 12~20 wt%; In step T1, the electrospinning solution, The mass of fiber raw material used is 1 g per 5 mL; In step T3, the conductive dispersion, The mass fraction of the conductive material raw material is 1.3 wt%.

9. The method for preparing a biomimetic skin conductive material according to claim 6, characterized in that, In step S3, the electrospinning, The voltage is 15~20kV; The syringe pump delivers the solution at a rate of 0.8~1 mL / h. -1 ; In step T2, the electrospinning, The voltage is 15~20kV; The syringe pump delivers the solution at a rate of 0.8~1 mL / h. -1 .

10. The use of a biomimetic skin conductive material as described in any one of claims 1 to 5 in the preparation of wound dressings or biomimetic skin.

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