Lung-moistening and anti-inflammatory sophora flower bud and lily pressed candy and preparation method thereof

Abstract

The invention discloses lung-moistening and anti-inflammatory sophora flower bud and lily pressed candies and a preparation method thereof, and belongs to the technical field of candy food processing. The lung-moistening and anti-inflammatory sophora flower bud and lily pressed candy is prepared from the following raw materials in parts by weight: 5 to 15 parts of sophora flower bud powder, 2 to 6 parts of medium chain triglyceride or coconut oil, 0.5 to 2 parts of soybean lecithin, 0.1 to 0.5 part of xanthan gum, 0.02 to 0.1 part of lily powder, 0.5 to 1 part of magnesium stearate, 1 to 4 parts of citric acid, 10 to 20 parts of fruit juice powder, 50 to 70 parts of sorbitol, 1 to 4 parts of sodium bicarbonate and 2 to 3 parts of water. According to the pagodatree flower bud and lily pressed candy, pagodatree flower bud powder, medium chain triglyceride or coconut oil, soya bean lecithin and the like are made into nano-emulsion, the nano-emulsion is subjected to spray drying to prepare powder, and then the powder is compounded with other auxiliary materials according to a specific process, so that the effective retention and absorption efficiency of active ingredients in the pagodatree flower bud powder is effectively improved, and the pagodatree flower bud and lily pressed candy is prepared. Therefore, the effect of the product is enhanced.

Description

Technical Field

[0001] This invention relates to a lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs, and its preparation method, belonging to the field of confectionery processing technology. Background Technology

[0002] Sophora japonica and lily bulb compressed candy has become a popular product on the market due to the lung-moistening and anti-inflammatory effects of active ingredients such as quercetin and rutin in Sophora japonica buds and lily polysaccharides in lily bulbs. This type of product uses medicinal and edible ingredients as its core, and is manufactured through processes such as crushing, mixing, and tableting, offering advantages such as convenient consumption and portability.

[0003] However, existing Sophora japonica and lily bulb compressed candies face core technological bottlenecks in their research and development and production, severely restricting the full realization of product efficacy. The core problems lie in the low utilization efficiency of core active ingredients and the loss of activity during processing. Traditional processing techniques for raw materials such as Sophora japonica and lily bulbs (such as high-temperature drying and mechanical pulverization) easily lead to oxidation, degradation, or structural damage of active ingredients, further reducing the retention rate of active ingredients and significantly diminishing product efficacy.

[0004] Based on this, existing technologies largely draw on delivery techniques from the pharmaceutical formulation field, primarily including cyclodextrin inclusion technology, microencapsulation technology, and liquid delivery system technology. Among these, cyclodextrin inclusion technology utilizes the hollow structure of cyclodextrin to form inclusion complexes with active ingredients such as quercetin, altering the solubility characteristics of the active ingredients and improving their water solubility and stability. Microencapsulation technology uses polymer materials to encapsulate active ingredients into microcapsules, reducing oxidative degradation during processing and allowing for slow release of the active ingredients in the gastrointestinal environment, thus prolonging the duration of action.

[0005] Although the aforementioned existing technologies attempt to address the technical challenges of existing Sophora japonica and lily bulb compressed candies to some extent, they all have significant shortcomings and cannot fundamentally balance the needs of improving the bioavailability of active ingredients with the suitability for industrial production of compressed candies.

[0006] Specifically, the use and dosage of some cyclodextrin derivatives used in cyclodextrin inclusion technology in the food industry are subject to strict regulations, which cannot meet the compliance requirements of compressed candy as a general food. Although microencapsulation technology can improve the stability of active ingredients, commonly used encapsulation materials are prone to elastic deformation during the tableting process, resulting in insufficient tablet hardness and brittleness. In addition, the encapsulation process may introduce the risk of organic solvent residue, affecting food safety.

[0007] Existing solutions generally lack a synergistic consideration of "active ingredient retention, bioavailability enhancement, and food processing compatibility." For example, some solutions can improve the stability of active ingredients but cannot improve their absorption efficiency; some solutions can improve solubility but cannot be adapted to the industrial production process of compressed candies; and some solutions, while improving one indicator, lead to the deterioration of other indicators (such as dilution of active ingredients due to the addition of large amounts of excipients, and a surge in production costs due to complex processes). These problems collectively result in the core defects of existing Sophora japonica and lily bulb compressed candies: low bioavailability of active ingredients and poor compatibility between the process and food form. As a result, the actual lung-moistening and anti-inflammatory effects of the products fall far short of consumer expectations and fail to meet market demand. Summary of the Invention

[0008] To address the shortcomings of existing technologies, the present invention aims to provide a lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs, and its preparation method. This method involves constructing a nanoemulsion from Sophora japonica powder, medium-chain triglycerides, coconut oil, and soybean lecithin, and then spray-drying it into powder. The powder is then combined with other excipients according to a specific process to prepare compressed candy, which effectively improves the retention and absorption efficiency of active ingredients in Sophora japonica powder, thereby enhancing the efficacy of the product.

[0009] To achieve the above objectives, the following technical solution is provided: This invention provides a lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs, comprising the following ingredients in parts by weight: 5-15 parts Sophora japonica powder, 2-6 parts medium-chain triglycerides or coconut oil, 0.5-2 parts soybean lecithin, 0.1-0.5 parts xanthan gum, 0.02-0.1 parts lily bulb powder, 0.5-1 part magnesium stearate, 1-4 parts citric acid, 10-20 parts fruit juice powder, 50-70 parts sorbitol, 1-4 parts sodium bicarbonate, and 2-3 parts water.

[0010] In one embodiment, the fruit juice powder includes one or more of concentrated orange juice powder, passion fruit juice powder, apple juice powder, lemon juice powder, and grape juice powder.

[0011] In one embodiment, the compressed candy made from Sophora japonica and lily bulbs comprises the following ingredients in parts by weight: 9.5 parts Sophora japonica powder, 4 parts medium-chain triglycerides or coconut oil, 2 parts soybean lecithin, 0.5 parts xanthan gum, 0.08 parts lily bulb powder, 0.092 parts magnesium stearate, 2.5 parts citric acid, 15 parts fruit juice powder, 63 parts sorbitol, 2.5 parts sodium bicarbonate, and 3 parts water.

[0012] This invention also provides a method for preparing the above-mentioned lung-moistening and anti-inflammatory Sophora japonica and lily bulb compressed candy, comprising the following steps: (1) After hydrating xanthan gum and soybean lecithin at 55-65℃, mix them with medium-chain triglycerides or coconut oil, perform preliminary emulsification by high-speed shearing, homogenize, then add sophora japonica powder, perform preliminary emulsification by high-speed shearing again, homogenize, and obtain a stable emulsion system; then spray dry to obtain a composite powder with good flowability. (2) Mix the composite powder obtained in step (1) with lily powder, magnesium stearate, citric acid and fruit juice powder evenly, and sieve to obtain an acid source; mix sorbitol and sodium bicarbonate evenly, and sieve to obtain an alkali source; (3) Granulate the acid source and alkali source obtained in step (2), compress them into tablets, dry them, and package them to obtain the product.

[0013] In one embodiment, the homogenization in step (1) is carried out in a high-pressure homogenizer at a pressure of 120-150 MPa, and the homogenization is repeated 2-3 times.

[0014] In one embodiment, the conditions for spray drying in step (1) are: inlet air temperature 160-180℃, outlet air temperature 75-85℃, and atomizer frequency 35-45Hz.

[0015] In one embodiment, the mesh size of the sieve in step (2) is 80 to 120 mesh.

[0016] In one embodiment, the tableting process in step (3) involves sending the granulated granules to a high-speed rotary tablet press and controlling the tablet hardness between 30-60 N by adjusting the pressure to a range of 30-60 kN.

[0017] In one embodiment, the drying in step (3) is carried out in a dynamic fluidized bed drying system.

[0018] In one embodiment, the drying temperature is 40-50°C and the time is 10-20 minutes.

[0019] In one embodiment, the packaging is heat-sealed using an aluminum-plastic blister pack or composite film bag with high water and oxygen barrier properties.

[0020] This invention also provides a method for improving the absorption rate of active ingredients in lung-moistening and anti-inflammatory Sophora japonica and lily bulb compressed candies, the method comprising the following steps: (1) After hydrating xanthan gum and soybean lecithin at 55-65℃, mix them with medium-chain triglycerides or coconut oil, perform preliminary emulsification by high-speed shearing, homogenize, then add sophora japonica powder, perform preliminary emulsification by high-speed shearing again, homogenize, and obtain a stable emulsion system; then spray dry to obtain a composite powder with good flowability. (2) Mix the composite powder obtained in step (1) with lily powder, magnesium stearate, citric acid and fruit juice powder evenly, and sieve to obtain an acid source; mix sorbitol and sodium bicarbonate evenly, and sieve to obtain an alkali source; (3) Granulate the acid source and alkali source obtained in step (2), compress them into tablets, dry them, and package them.

[0021] In one embodiment, the homogenization in step (1) is carried out in a high-pressure homogenizer at a pressure of 120-150 MPa, and the homogenization is repeated 2-3 times.

[0022] In one embodiment, the conditions for spray drying in step (1) are: inlet air temperature 160-180℃, outlet air temperature 75-85℃, and atomizer frequency 35-45Hz.

[0023] In one embodiment, the mesh size of the sieve in step (2) is 80 to 120 mesh.

[0024] In one embodiment, the tableting process in step (3) involves sending the granulated granules to a high-speed rotary tablet press and controlling the tablet hardness between 30-60 N by adjusting the pressure to a range of 30-60 kN.

[0025] In one embodiment, the drying in step (3) is carried out in a dynamic fluidized bed drying system.

[0026] In one embodiment, the drying temperature is 40-50°C and the time is 10-20 minutes.

[0027] In one embodiment, the packaging is heat-sealed using an aluminum-plastic blister pack or composite film bag with high water and oxygen barrier properties.

[0028] Beneficial effects: The beneficial effects of this invention are that it addresses the core problems of existing lung-moistening and anti-inflammatory Sophora japonica and lily bulb compressed candies, such as low bioavailability of active ingredients, easy inactivation due to traditional processing, and incompatibility between high-efficiency delivery systems and solid-state food production processes; it has the following advantages: First, by constructing a "Sophora japonica powder nanoemulsion" and combining it with spray drying microencapsulation technology, the liquid high-efficiency delivery system was successfully transformed into a solid functional powder with good flowability, fundamentally solving the problem of morphological compatibility between high-efficiency nano-formulations and dry tableting processes; Secondly, this technical solution greatly improves the solubility of hydrophobic components such as quercetin through nanoemulsification, and provides physical protection by utilizing microcapsule wall materials. Combined with the instantaneous low temperature characteristics of spray drying, it synergistically overcomes the two major problems of "poor solubility" and "easy inactivation during processing", significantly improving the bioavailability and processing stability of the active ingredients. Of particular note is that this invention, through the selection of specific wall materials and optimization of the encapsulation process, enables the prepared compressed candy to achieve controlled release in a simulated digestive environment and significantly improves the transmembrane permeation efficiency of active ingredients. Experiments show that this encapsulation system can effectively promote the intestinal absorption of active ingredients such as quercetin in Sophora japonica buds, and its membrane permeation rate is significantly improved compared with ordinary extracts without encapsulation, thereby further improving bioavailability from the absorption stage and enhancing the actual efficacy of the product. Finally, by scientifically compounding and optimizing the tableting process of the solid formulation containing this functional powder, the final product is ensured to have excellent taste, hardness and disintegration properties, realizing a smooth transformation from high-efficiency raw materials to high-quality end consumer products. This provides the food industry with a complete process path to effectively improve the actual efficacy of products. Attached Figure Description

[0029] Figure 1 This is a photograph of the lung-moistening and anti-inflammatory Sophora japonica and lily bulb compressed candy prepared in Example 1 of the present invention. Detailed Implementation

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. The specific embodiments described below further illustrate the present invention.

[0031] The testing method involved in this invention 1. Sophora japonica flower powder encapsulation rate Weigh sample W (approximately 2g) on ​​filter paper, place it on a constant weight centrifuge tube, and wash the powder sample repeatedly with 10mL of anhydrous ethanol. Evaporate the solvent in an explosion-proof oven at 80℃, and calculate the surface Sophora japonica powder as shown in formula (1): Surface Sophora japonica powder (%) = *100(1) Where W refers to the spray-dried Sophora japonica powder (g), m: centrifuge tube weight (g), and m1: centrifuge tube weight (g) containing surface Sophora japonica powder. Determination of the encapsulation rate of Sophora japonica powder: MEE (%) = *100 (2) The total amount of Sophora japonica powder is the amount of Sophora japonica powder added before encapsulation.

[0032] 2. Membrane permeability Select a molecular weight cutoff of 500-1000 Daltons (Da); place a quantitative amount of compressed candy (the total amount of Sophora japonica in the candy is calculated based on the amount added during candy preparation) into a dialysis bag containing water, seal the dialysis bag, place it in a beaker containing water for 1 hour, remove the dialysis bag, and measure the amount of Sophora japonica powder in the beaker; evaporate the moisture in an explosion-proof oven at 105℃, and calculate the amount of Sophora japonica powder as shown in formula (3): MEE (%) = *100 (3).

[0033] The source of raw materials involved in this invention: Sophora japonica flower powder and lily powder were purchased from Shanxi Jinnian Biotechnology Co., Ltd. Soybean lecithin was purchased from Henan Shengfa Biotechnology Co., Ltd. Concentrated orange juice powder and passion fruit juice powder were purchased from Topcon Health Technology (Nantong) Co., Ltd.

[0034] Example 1 A lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs comprises the following ingredients in parts by weight, each part being 1g: 9.5 parts Sophora japonica powder, 4 parts medium-chain triglycerides, 2 parts soy lecithin, 0.5 parts xanthan gum, 0.08 parts lily bulb powder, 0.92 parts magnesium stearate, 2.5 parts citric acid, 15 parts concentrated orange juice powder, 63 parts sorbitol, 2.5 parts sodium bicarbonate, and 3 parts water.

[0035] Its preparation method includes the following steps: (1) Preparation of emulsion system Xanthan gum and soybean lecithin were hydrated in water at 60°C, and then medium-chain triglycerides were added. The mixture was initially emulsified by high-speed shearing, and then homogenized three times under 130 MPa pressure using a high-pressure homogenizer to form an emulsion system. Sophora japonica powder was then added to the emulsion system, and the mixture was initially emulsified by high-speed shearing, and then homogenized three times under 140 MPa pressure using a high-pressure homogenizer to form an emulsion system with uniform and stable particle size. (2) Preparation of pretreated powder The emulsion system with uniform and stable particle size obtained in step (1) was immediately spray-dried, with the inlet air temperature controlled at 170°C, the outlet air temperature at 80°C, and the atomizer frequency at 40Hz, to obtain a composite powder with good flowability; the composite powder was collected and immediately placed in a dry environment to cool to room temperature, then sealed and packaged to obtain pretreated powder. (3) Acid-base granulation Under low temperature (18-25℃) and low humidity (relative humidity <40%) environment, the pretreated powder obtained in step (2) is mixed evenly with lily powder, magnesium stearate, citric acid and fruit juice powder, and passed through an 80-mesh screen to obtain an acid source; sorbitol and sodium bicarbonate are mixed evenly and passed through an 80-mesh screen to obtain an alkali source; Mix the acid source and alkali source evenly, spray with 90% ethanol solution until the material reaches a sticky state that "can be clumped together by hand and dispersed by light touch", sieve and granulate, then dry at 48-50℃, sieve again to obtain granules with uniform particle size. (4) Tableting The particles obtained in step (3) are sent to a high-speed rotary tablet press. The tablet hardness is controlled between 30-60N by adjusting the pressure to 30-60kN. The pressed tablets are immediately processed in a dynamic fluidized bed drying system at a low temperature of 40℃ for 10-20 minutes. The dried tablets are then loaded into aluminum-plastic blister packs or composite film bags by an automatic counting and filling machine and heat-sealed.

[0036] Example 2 A lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs comprises the following ingredients in parts by weight, each part being 1g: 9.5 parts Sophora japonica powder, 4 parts coconut oil, 2 parts soy lecithin, 0.5 parts xanthan gum, 0.08 parts lily bulb powder, 0.92 parts magnesium stearate, 2.5 parts citric acid, 15 parts concentrated orange juice powder, 63 parts sorbitol, 2.5 parts sodium bicarbonate, and 3 parts water.

[0037] The preparation method is the same as in Example 1.

[0038] Example 3 A lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs comprises the following ingredients in parts by weight, each part being 1g: 9.5 parts Sophora japonica powder, 4 parts medium-chain triglycerides, 2 parts soy lecithin, 0.5 parts xanthan gum, 0.08 parts lily bulb powder, 0.92 parts magnesium stearate, 2.5 parts citric acid, 15 parts passion fruit juice powder, 63 parts sorbitol, 2.5 parts sodium bicarbonate, and 3 parts water.

[0039] The preparation method is the same as in Example 1.

[0040] Comparative Example 1 The only difference from Example 1 is that the medium-chain triglycerides are replaced with corn oil, while all other parameters and conditions are the same as in Example 1.

[0041] Comparative Example 2 The only difference from Example 1 is that the use of soybean lecithin is omitted; all other parameters and conditions are the same as in Example 1.

[0042] Comparative Example 3 The only difference from Example 1 is that in its preparation method, step (3) acid-base granulation is specifically as follows: Half of the pretreated powder obtained in step (2) was mixed evenly with lily powder, magnesium stearate, citric acid and fruit juice powder, and passed through an 80-120 mesh screen to obtain an acid source; the other half of the pretreated powder was mixed evenly with sorbitol and sodium bicarbonate, and passed through an 80-120 mesh screen to obtain an alkali source; other parameters and conditions were the same as in Example 1.

[0043] Comparative Example 4 The difference from Example 1 is that its preparation method omits steps (1) and (2); step (3) specifically is: Sophora japonica powder, soybean lecithin, medium-chain triglycerides, lily powder, magnesium stearate, citric acid, and concentrated orange juice powder were mixed evenly and passed through an 80-mesh screen to obtain an acid source; sorbitol and sodium bicarbonate were mixed evenly and passed through an 80-mesh screen to obtain an alkali source; other parameters and conditions were the same as in Example 1.

[0044] Results Analysis The performance of the Sophora japonica and lily bulb compressed candies prepared in the examples and comparative examples was determined, and the results are shown in Table 1: Table 1. Performance of Sophora japonica and lily bulb compressed candy

[0045] The embodiments provided above are not intended to limit the scope of the invention, nor are the described steps intended to limit the order of execution. Any obvious modifications made to the invention by those skilled in the art based on existing common knowledge also fall within the scope of protection defined by the claims.

Claims

1. A lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs, characterized in that, It consists of the following ingredients in parts by weight: 5-15 parts Sophora japonica powder, 2-6 parts medium-chain triglycerides or coconut oil, 0.5-2 parts soybean lecithin, 0.1-0.5 parts xanthan gum, 0.02-0.1 parts lily powder, 0.5-1 part magnesium stearate, 1-4 parts citric acid, 10-20 parts fruit juice powder, 50-70 parts sorbitol, 1-4 parts sodium bicarbonate, and 2-3 parts water.

2. The compressed candy made from Sophora japonica and lily bulbs according to claim 1, characterized in that, The fruit juice powder includes one or more of the following: concentrated orange juice powder, passion fruit juice powder, apple juice powder, lemon juice powder, and grape juice powder.

3. The compressed candy made from Sophora japonica and lily bulbs according to claim 1, characterized in that, The compressed candy made from Sophora japonica and lily bulbs comprises the following ingredients in parts by weight: 9.5 parts Sophora japonica powder, 4 parts medium-chain triglycerides or coconut oil, 2 parts soy lecithin, 0.5 parts xanthan gum, 0.08 parts lily bulb powder, 0.092 parts magnesium stearate, 2.5 parts citric acid, 15 parts fruit juice powder, 63 parts sorbitol, 2.5 parts sodium bicarbonate, and 3 parts water.

4. A method for preparing a lung-moistening and anti-inflammatory compressed candy made from Sophora japonica and lily bulbs according to any one of claims 1 to 3, characterized in that, Includes the following steps: (1) After hydrating xanthan gum and soybean lecithin at 55-65℃, mix them with medium-chain triglycerides or coconut oil, perform preliminary emulsification by high-speed shearing, homogenize, then add sophora japonica powder, perform preliminary emulsification by high-speed shearing again, homogenize, and obtain a stable emulsion system; then spray dry to obtain a composite powder with good flowability. (2) Mix the composite powder obtained in step (1) with lily powder, magnesium stearate, citric acid and fruit juice powder evenly, and sieve to obtain an acid source; mix sorbitol and sodium bicarbonate evenly, and sieve to obtain an alkali source; (3) Granulate the acid source and alkali source obtained in step (2), compress them into tablets, dry them, and package them to obtain the product.

5. The method according to claim 4, characterized in that, The homogenization in step (1) is carried out in a high-pressure homogenizer at a pressure of 120-150 MPa, and the homogenization is repeated 2-3 times.

6. The method according to claim 4, characterized in that, The conditions for spray drying in step (1) are: inlet air temperature 160-180℃, outlet air temperature 75-85℃, and atomizer frequency 35-45Hz.

7. The method according to claim 4, characterized in that, Step (3) involves sending the granulated granules to a high-speed rotary tablet press and adjusting the pressure to a range of 30-60 kN to control the tablet hardness between 30-60 N for tableting.

8. The method according to claim 4, characterized in that, The drying in step (3) is carried out in a dynamic fluidized bed drying system.

9. The method according to claim 4, characterized in that, The packaging in step (3) is heat-sealed using aluminum-plastic blister packs or composite film bags with high water and oxygen barrier properties.

10. A method for improving the absorption rate of active ingredients in lung-moistening and anti-inflammatory Sophora japonica and lily bulb compressed candies, characterized in that, The method includes the following steps: (1) After hydrating xanthan gum and soybean lecithin at 55-65℃, mix them with medium-chain triglycerides or coconut oil, perform preliminary emulsification by high-speed shearing, homogenize, then add sophora japonica powder, perform preliminary emulsification by high-speed shearing again, homogenize, and obtain a stable emulsion system; then spray dry to obtain a composite powder with good flowability. (2) Mix the composite powder obtained in step (1) with lily powder, magnesium stearate, citric acid and fruit juice powder evenly, and sieve to obtain an acid source; mix sorbitol and sodium bicarbonate evenly, and sieve to obtain an alkali source; (3) Granulate the acid source and alkali source obtained in step (2), compress them into tablets, dry them, and package them.

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