Traditional Chinese medicine composition for relieving visual fatigue

Abstract

The invention provides a traditional Chinese medicine composition for relieving visual fatigue, which is characterized by being prepared from the following raw materials in parts by weight: 0.1 to 1.5 parts of fructus lycii, 0.05 to 1.47 parts of flos chrysanthemi, 0.02 to 0.5 part of radix ginseng, 0.02 to 0.7 part of herba cistanche, 0.2 to 1.2 parts of roselle, 0.02 to 0.37 part of liquorice root, 18 to 25 parts of green tangerine peel and 7 to 12 parts of Pu'er tea. Experiments show that compared with a food group before and after trial feeding and compared with a control group after trial feeding, the photopic vision persistence is improved, and the effect of relieving visual fatigue is achieved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of medical technology, and particularly relates to a traditional Chinese medicine composition for relieving visual fatigue. BACKGROUND

[0002] Visual fatigue is a common eye disease, and its specific manifestations include eye dryness, acid swelling, visual double images, and intermittent visual blurring, and severe visual fatigue can cause nausea, vomiting, dizziness, headache, neck muscle tension, shoulder pain and other systemic symptoms, reduce the work efficiency of adults, cause learning disabilities of teenagers and children, and directly affect the work and life of people.

[0003] According to traditional Chinese medicine, if the eyes continuously stare at close targets for a long time, the eyes are prone to overwork and cause symptoms such as eye swelling and headache, and the eye is the orifice of the liver, so it is called liver overwork. The development of contemporary society and the progress of technology have also increased the burden on the eyes of modern people, and the primary reason is the use of computers, mobile phones and other electronic products, followed by lack of eye care, unhealthy eye use, busy work, high pressure and the like. In particular, the continuous electric radiation of the display screen of electronic products can cause eye spasm, thereby producing a feeling of fatigue. The damage of visual fatigue to the eyes is not only manifested as a feeling of "tiredness", but also the problems such as an increasing number of dry eye patients, a record-high incidence of myopia, and a low age of eye diseases, which have become very serious and are increasing year by year. According to the theory of traditional Chinese medicine, the pathogenesis of liver overwork (visual fatigue) includes overwork of the heart and spirit, consumption of qi and blood, obstruction of tendons and blood vessels, deficiency of liver and kidney essence and blood, deficiency of spleen qi, and failure of clear yang to ascend. Among them, the main pathogenesis is the disorder of tendons and muscles in the eye. The treatment method should focus on nourishing the liver and kidney, clearing the liver and eyes, and regulating the tendons and muscles.

[0004] Green orange tea (small green orange Pu'er tea) is a characteristic tea drink made of Yunnan Pu'er tea and Xinhui green orange peel, and has multiple medicinal values such as regulating qi and invigorating the spleen, clearing heat and reducing phlegm. Green orange tea gradually becomes popular due to its unique taste. In order to expand the effect of green orange tea, the present application combines green orange tea with a traditional Chinese medicine composition capable of relieving visual fatigue, and proposes a traditional Chinese medicine composition for relieving visual fatigue. SUMMARY

[0005] The technical problem to be solved by the present application is to provide a traditional Chinese medicine composition for relieving visual fatigue. The present application adopts the following technical scheme:

[0006] A traditional Chinese medicine composition for relieving visual fatigue, which comprises the following raw materials in parts by weight: 0.1-1.5 parts of wolfberry, 0.05-1.47 parts of chrysanthemum, 0.02-0.5 parts of ginseng, 0.02-0.7 parts of cistanche, 0.2-1.2 parts of roxburgh rose, 0.02-0.37 parts of licorice, 7-12 parts of Pu'er tea, and 18-25 parts of green orange peel.

[0007] Optionally, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1.2 parts of wolfberry, 1.1 parts of chrysanthemum, 0.2 parts of ginseng, 0.5 parts of cistanche, 0.9 parts of hibiscus, 0.1 parts of licorice, 20 parts of green citrus shell, and 9 parts of Pu'er tea.

[0008] A traditional Chinese medicine preparation prepared from the above traditional Chinese medicine composition.

[0009] Optionally, the traditional Chinese medicine preparation is a tea beverage.

[0010] Optionally, the traditional Chinese medicine preparation is obtained by placing wolfberry, chrysanthemum, ginseng, cistanche, hibiscus, licorice, and Pu'er tea inside a green citrus shell.

[0011] Optionally, the traditional Chinese medicine preparation further comprises taurine.

[0012] Optionally, the weight ratio of taurine to green citrus is 0.08-0.18:1.

[0013] A portable tea beverage brewing device, comprising:

[0014] A support plate provided with a through hole;

[0015] A filter bag fixed below the support plate, and the filter bag is provided with the traditional Chinese medicine preparation according to any one of the preceding embodiments;

[0016] A sealing sheet pasted on the upper part of the support plate, and the sealing sheet covers the through hole.

[0017] Optionally, the pore size of the filter bag is 0.5-2 mm.

[0018] Optionally, the support plate is made of virgin wood pulp material.

[0019] The filter bag is made of virgin wood pulp material.

[0020] The wolfberry is sweet and flat, and belongs to the liver and kidney channels, and is rich in carotene, vitamin A and wolfberry polysaccharide, and can relieve blurred vision, night blindness and common eye fatigue and dryness of modern people. Chrysanthemum can clear liver meridian wind-heat, and improve dizziness and headache caused by liver yang hyperactivity, and red and swollen eyes. Modern research shows that it contains flavonoids, which can effectively relieve visual fatigue caused by electronic screens. Ginseng, as a traditional precious Chinese herbal medicine, can relieve insomnia, dreaminess, palpitation and forgetfulness, and enhance memory. Cistanche, as a traditional Chinese medicine, can improve myocardial ischemia, regulate blood pressure, promote immune cell proliferation, scavenge free radicals and delay aging. Rosebay (roselle) is a traditional Chinese medicine for both food and medicine, which is cool and sour, and can relieve dry mouth and throat pain caused by summer heat, and is suitable for drinking in summer, but people with spleen and stomach deficiency should be combined with ginger or brown sugar to neutralize the cold nature, and the flavonoid components can reduce alcohol or drug-induced liver damage and improve liver function. Licorice contains glycyrrhizic acid, which can inhibit the release of inflammatory mediators, bidirectionally regulate immune function, and scavenge free radicals to delay cell aging. Taurine helps to improve physical and mental strength. Qinggan belongs to the liver and gallbladder channels, contains synephrine and lipase, promotes fat decomposition and metabolism, is suitable for obese and hyperlipidemic people, is rich in flavonoids and tea polyphenols, delays cell aging, and assists in reducing blood pressure and cholesterol. It is found through experiments that the clear vision duration of the test group is improved after the test, and there is a significant difference (P<0.001), and the average clear vision duration of the test group is improved by 11.3% after the test, which is higher than that of the control group, and there is a significant difference (P<0.001). The vision and eye use time of the test group and the control group have no obvious change before and after the test. According to the judgment standard of the test method for relieving visual fatigue in the Health Food Function Test and Evaluation Method (2023 Edition), the results show that the traditional Chinese medicine composition for relieving visual fatigue of the application has the effect of relieving visual fatigue.

[0021] The application also provides a portable tea infusion device, which is in the shape of a flying saucer, is suitable for all cups, can be placed on a cup by tearing the upper part, and can start water injection, so that tea water can leak out of the filter screen, has a good appearance, is convenient to carry, is suitable for all cups, has more flavor of the tea soup, and is convenient to discard after use. BRIEF DESCRIPTION OF DRAWINGS

[0022] In order to more clearly illustrate the specific embodiments of the application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or prior art description. Obviously, the drawings in the following description are some embodiments of the application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0023] Figure 1 The structural schematic diagram of Example 3.

[0024] Figure 2Schematic diagram of the use mode of Example 3. DETAILED DESCRIPTION

[0025] The following detailed description is presented to describe certain exemplary embodiments of the application. It should be appreciated that the detailed description is presented for the purpose of describing the application and is not intended to limit the application. The terminology used in the description presented herein is for describing particular embodiments only and is not intended to be limiting of the application.

[0026] In addition, for numerical ranges of the present application, it is to be understood that every intermediate value of the upper and lower limits of the range is specifically included. Each smaller range between any stated value or intervening value in any stated range, and any other stated value or intervening value in any stated range is also encompassed within the application. The upper and lower limits of these smaller ranges can independently be included or excluded in the range.

[0027] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Although preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present application.

[0028] As used herein, the terms "comprise", "comprising", "include", "including", "have", "having", and the like are open-ended terms that are intended to mean including, but not limited to.

[0029] Example 1

[0030] The Chinese medicinal materials were weighed according to the following proportions:

[0031] 1.2 parts of wolfberry, 1.1 parts of chrysanthemum, 0.2 parts of ginseng, 0.5 parts of cistanche, 0.9 parts of roxburgh rose, 0.1 parts of licorice, and 20 parts of green citrus shell (one), and 9 parts of Pu'er tea.

[0032] Then, the wolfberry, chrysanthemum, ginseng, cistanche, roxburgh rose, Pu'er tea, and licorice were placed inside the green citrus shell to obtain the green citrus tea for relieving visual fatigue.

[0033] Example 2

[0034] The Chinese medicinal materials were weighed according to the following proportions:

[0035] 1.2 parts of wolfberry, 1.1 parts of chrysanthemum, 0.2 parts of ginseng, 0.5 parts of cistanche, 0.9 parts of roxburgh rose, 0.1 parts of licorice, and 20 parts of green citrus shell (one), and 9 parts of Pu'er tea, and 2 parts of taurine.

[0036] Then, goji berries, chrysanthemum, ginseng, cistanche, roselle, Pu-erh tea, taurine, and licorice are placed inside the green tangerine peel to obtain green tangerine tea for relieving eye strain.

[0037] Example 3

[0038] Small green tangerine tea typically requires special teaware for brewing. If brewed directly, the flavor is very strong, and the medicinal herbs in the green tangerine will be extracted, ruining its appearance. This embodiment proposes a portable tea brewing device, such as... Figure 1 As shown, the portable tea brewing device includes:

[0039] Support plate 2, wherein the support plate is provided with through holes;

[0040] The filter bag 3 is fixed below the support plate; and the green tangerine tea 4 in embodiment 2 is placed inside the filter bag; the pore size of the filter bag is 0.5-2mm so that the tea water can pass through the filter.

[0041] A sealing sheet 1 is attached to the upper part of the support plate and covers the through hole.

[0042] Both the support plate and the mesh bag are made of virgin wood pulp material;

[0043] like Figure 2 As shown, the portable tea brewing device described above is saucer-shaped and suitable for all cups. Tear off the top sealing sheet, place the support plate on the cup, and you can start pouring water. The tea will leak out through the filter. It has a good appearance, is easy to carry, adapts to all cups, produces more flavorful tea, and is easy to discard after use.

[0044] Example 4

[0045] Weigh the Chinese herbal raw materials according to the following weight proportions:

[0046] 1.5 parts goji berries, 1.47 parts chrysanthemum, 0.5 parts ginseng, 0.7 parts cistanche, 1.2 parts roselle, 0.37 parts licorice, 12 parts Pu-erh tea, and 25 parts green tangerine peel (one).

[0047] Then, goji berries, chrysanthemum, ginseng, cistanche, roselle, Pu-erh tea, and licorice are placed inside the green tangerine peel to obtain green tangerine tea, which is used to relieve eye strain.

[0048] Example 5

[0049] Weigh the Chinese herbal raw materials according to the following weight proportions:

[0050] 0.1 part goji berries, 0.05 part chrysanthemum, 0.02 part ginseng, 0.02 part cistanche, 0.2 part roselle, 0.02 part licorice, 7 parts Pu-erh tea, 18 parts green tangerine peel (one).

[0051] Then the wolfberry, chrysanthemum, ginseng, cistanche, rosette flower, pu'er tea and licorice are placed inside the green citrus shell to obtain the green citrus tea for relieving visual fatigue.

[0052] Test Example 1

[0053] 1 Materials and Methods

[0054] 1.1 Sample:

[0055] The product in Example 3 is used.

[0056] A placebo is obtained by replacing the other Chinese medicinal materials in Example 3 with the same weight of pu'er tea. The placebo is consistent with the test product in terms of efficacy components, taste, appearance and packaging.

[0057] 1.2 Test Subjects:

[0058] 1.2.1 Inclusion Criteria:

[0059] 1.2.1.1 Adults aged 18-65 years.

[0060] 1.2.1.2 People who use their eyes for a long time and are prone to visual fatigue.

[0061] 1.2.2 Exclusion Criteria

[0062] 1.2.2.1 Patients with infectious or traumatic eye diseases. Patients who have undergone eye surgery for less than 3 months.

[0063] 1.2.2.2 Patients with corneal, lens, vitreous, fundus and other internal and external eye diseases.

[0064] 1.2.2.3 Patients with cardiovascular, cerebrovascular, liver, kidney, hematopoietic system and other diseases.

[0065] 1.2.2.4 Pregnant or lactating women, patients with allergic constitution.

[0066] 1.2.2.5 Patients who have taken relevant items related to the test function within a short period of time, affecting the judgment of the results.

[0067] 1.2.2.6 Patients who have taken relevant drugs for treating vision, health products or other treatment methods for a long time and have not been able to stop.

[0068] 1.2.2.7 Patients who do not meet the inclusion criteria, do not eat the test product as required, or have incomplete data that affect the judgment of efficacy or safety.

[0069] 1.3 Test Design and Grouping

[0070] Self and inter-group control design was adopted. According to the requirements of random and double-blind, the groups were divided according to the symptoms and visual examination, so that the symptoms and visual levels of the test group and the control group were balanced. At the same time, the factors such as age and gender were considered to make the two groups comparable. The number of subjects in each group at the end of the test was not less than 50 cases.

[0071] 1.4 Dose and time The subjects stopped taking the drugs or other health care products related to improving vision during the test period. The original dietary habits were not changed during the test period, and the normal diet was maintained.

[0073] 1.5 Instruments and reagents

[0074] ModularP full-automatic biochemical analyzer (Roche Diagnostics, Germany); TBA-120 full-automatic biochemical analyzer (TOSHIBA, Japan); Clinitek Advantus urine analyzer (SIEMENS); Sysmex-K21 three-class blood analyzer (Sysmex); Sysmex blood cell analysis diluent (Sysmex); Multistix10SG urine analysis reagent strip (SIEMENS); biochemical reagent kit produced by Roche Diagnostics Co., Ltd. in Germany, provided by Roche Diagnostics (Shanghai) Co., Ltd.

[0075] 2 Observation index

[0076] 2.1 Efficacy index

[0077] 2.1.1 Questionnaire survey: symptom inquiry, eye use (computer use, TV watching, book and newspaper reading, etc.).

[0078] 2.1.2 Ophthalmic examination: including fundus examination, visual examination (myopia, hyperopia, astigmatism, etc.).

[0079] 2.1.3 Duration of photopic vision detection

[0080] Photopic duration determination method: draw a "pin" shaped solid block diagram on the examination table, each side of the block is one centimeter long, and the local illumination is 100-150LX (a special lamp box can be used). The distance between the examination table and the eye should be kept at a proper distance according to the visual habits of the subjects, and it is specified that the subjects see the "pin" image as photopic, and the inverted "pin" as non-photopic. The measurement time is 3 minutes.

[0081] Photopic duration = (photopic time / total fixation time) x 100%

[0082] 2.2 Safety index

[0083] 2.2.1 Blood, urine routine and stool routine examination

[0084] Red blood cell count, hemoglobin, white blood cell count, urine routine, stool routine examination.

[0085] 2.2.2 Biochemical index determination

[0086] Serum albumin (AIb), total protein (TP), liver and kidney function (glutamic-oxalacetic transaminase (AST), glutamic-pyruvic transaminase (ALT), urea (Urea), creatinine (Cre)), blood sugar (Glu), blood lipid (total cholesterol (TC), triglyceride (TG)).

[0087] 2.2.3 Abdominal B-ultrasound, electrocardiogram, chest X-ray (examined once before test feeding).

[0088] 2.3 Efficacy determination

[0089] 2.3.1 Effective rate of symptom improvement

[0090] Three of the eight symptoms of eye pain, eye swelling, photophobia, blurred vision, dry eyes, foreign body sensation, tearing, and general malaise are improved, and other symptoms are not worsened, which is determined as symptom improvement. The number of cases of symptom improvement in the two groups and the effective rate of symptom improvement in the two groups are calculated. The calculation method of the effective rate of symptom improvement (%) is symptom improvement cases / test feeding cases x 100. The effective rates of symptom improvement in the two groups are statistically tested.

[0091] 2.3.2 Average symptom score

[0092] The symptom scores of each test subject before and after test feeding are calculated, the average scores of the two groups are calculated respectively, and statistical test is performed.

[0093] Table 1 Visual fatigue symptom determination method (semi-quantitative scoring method)

[0094]

[0095] Note: "occasionally" refers to 1-2 times / day; "sometimes" refers to 1-3 times / day; "often" refers to >3 times / day

[0096] 2.3.3 Visual acuity improvement rate

[0097] It is a reference index. The improvement of two after test feeding compared with before test feeding is considered as improvement, and the visual acuity improvement rate after taking the test substance in the two groups is calculated as a reference index. The reference index is not used as a criterion for determining whether the function of relieving visual fatigue is effective.

[0098] 2.3.4 Duration of clear vision

[0099] The difference in duration of clear vision is significant (P<0.05) in self-comparison of the test group or inter-group comparison of the test group and the control group, and the average duration of clear vision is increased by more than or equal to 10%, which is effective.

[0100] 2.4 Statistical analysis

[0101] The measurement data were analyzed by t-test. The paired t-test was used for self-control, and the group t-test was used for comparison of the means of two groups. For data that were not normally distributed or had heterogeneous variances, appropriate variable transformation was performed, and t-test was used after the data met the normality and homogeneity of variance. If the transformed data still did not meet the normality and homogeneity of variance, the chi-square test or rank sum test was used. Under the premise that there was no significant difference between the groups before the test, the comparison between the groups after the test could be performed.

[0102] The count data were analyzed by X2test. If the total number of four-fold table was less than 40, or the total number was equal to or greater than 40 but the theoretical frequency was equal to or less than 1, the exact probability method should be used.

[0103] 2.5 Results determination

[0104] 2.5.1 The effective rate of symptom improvement or the difference in total symptom score was significant (P < 0.05) in the self-comparison of the test group or the comparison between the test group and the control group.

[0105] 2.5.2 The difference in duration of clear vision was significant (P < 0.05) in the self-comparison of the test group or the comparison between the test group and the control group, and the average duration of clear vision was increased by more than or equal to 10%.

[0106] If both 2.5.1 and 2.5.2 were met and the improvement rate of vision was not significantly reduced, it was determined that the test substance had the function of helping to relieve visual fatigue.

[0107] 3 Test results

[0108] 3.1 Efficacy observation results

[0109] 3.1.1 General condition

[0110] A total of 110 subjects were enrolled and randomly divided into a test group and a control group. Three subjects in the test group and five subjects in the control group were lost, and 102 subjects were effective, including 52 subjects in the test group and 50 subjects in the control group. The subjects had normal test results in blood, urine, stool routine, blood biochemical indicators, chest X-ray, electrocardiogram, and abdominal B-ultrasound before the test. The grouping is shown in Table 2, and there was no significant difference in age, gender, duration of clear vision, visual acuity, total symptom score, and eye use time between the two groups before the test (P > 0.05), which was comparable.

[0111]

[0112] 3.1.2 Change in total symptom score

[0113] Table 3 Change in total symptom score before and after the test

[0114] Group Example Before test After test Test group 52 4.55±1.63 2.83±1.79***### Control group 50 4.43±1.74 4.42±1.63

[0115] ***P<0.001, ###P<0.001

[0116] 3.1.3 Improvement of main symptoms

[0117] Table 4 Improvement of main symptoms

[0118] Main symptoms Example Effective example Ineffective example Effective rate (%) Eye swelling 25(20) 14(0) 11(20) 56.0(0) Eye pain 26(25) 15(0) 11(25) 57.7(0) Photophobia 22(19) 13(2) 9(17) 59.1(10.5) Visual blurring 26(20) 14(3) 12(17) 53.8(15) Dry eyes 20(23) 10(2) 10(21) 50.0(8.7) Foreign body sensation 24(23) 9(0) 15(23) 37.5(0) Lacrimation 19(10) 8(0) 11(10) 42.1(0) General malaise 20(27) 9(0) 11(27) 45.0(0)

[0119] Data of test group (data of control group)

[0120] 3.1.4 Effective rate of symptom improvement

[0121] Table 5 Comparison of effective rate of symptom improvement

[0122]

[0123] ###P<0.001

[0124] 3.1.5 Change of duration of clear vision

[0125] Table 6 Change of duration of clear vision before and after test

[0126] Group Example Before test After test Increase value (%) Test group 52 56.3±7.5 67.5±5.4***#### 11.3±3.6### Control group 50 58.3±6.7 60.1±5.4 1.7±2.4

[0127] From Tables 3, 5 and 6, it can be seen that the total symptom scores of the test group before and after test and after test compared with the control group were improved obviously (P<0.001); 23 cases were improved effectively after test, and the effective rate of symptom improvement was 44.2%, which had significant difference compared with the control group (P<0.001); the duration of clear vision was improved, and there were significant differences (P<0.001) before and after test of the test group and after test compared with the control group; the average duration of clear vision of the test group after test was increased by 11.3%, which was higher than that of the control group, and there was significant difference (P<0.001).

[0128] 3.1.6 Detection results of distant vision

[0129] Table 7 Improvement results of vision

[0130]

[0131] Table 8 Improvement rate of vision

[0132] Group Example Effective Ineffective Improvement rate (%) Test group 52 Left eye vision 0 52 0 Right eye vision 0 52 0 Control group 50 Left eye vision 0 50 0 Right eye vision 0 50 0

[0133] 3.1.7 Time of using eyes

[0134] Table 9 Change of time of using eyes before and after test

[0135] Group Example Before test (h) After test (h) Test group 52 4.56±1.20 4.50±1.14 Control group 50 4.66±1.18 4.62±1.05

[0136] From table 7, 8, 9, it can be seen that the left eye vision and right eye vision, and the time of using eyes have no obvious change in self-comparison before and after the test and comparison after the test with the control group.

[0137] 3.2 Safety observation results

[0138] 3.2.1 Blood routine, urine routine, stool routine and blood biochemical indexes before and after the test

[0139] The blood, urine, stool routine and blood biochemical indexes of the subjects before and after the test are basically in the normal range, as shown in table 10; the mental state, sleep, diet, defecation, blood pressure and heart rate of the subjects in the two groups before and after the test have no obvious change, as shown in table 11.

[0140] Table 10 Blood, urine, stool routine and blood biochemical indexes before and after the test

[0141] Before test After test Before test After test RBC(x10 12 / L) 4.54±037 4.53±0.64 4.58±0.34 4.60±0.29 [WBC(x10 9 / L)]]> 5.82±1.38 5.64±1.17 6.09±1.38 6.03±1.54 PLT(x10 9 / L) 224.17±60.35 232.49±61.38 234.77±52.26 243.18±44.57 HGB (g / L) 137.20±11.24 136.37±11.64 142.15±11.32 140.35±10.15 TP (g / L) 73.91±3.48 73.87±4.65 75.34±3.57 75.56±3.13 Alb (g / L) 46.28±2.14 46.76±1.66 46.63±1.84 46.26±2.07 ALT (U / L) 20.30±7.16 21.35±8.47 22.67±11.11 23.26±12.47 AST (U / L) 20.72±4.38 21.61±4.32 21.38±7.32 21.24±6.36 Urea (mmol / L) 5.44±1.34 5.44±1.17 5.13±1.09 5.24±1.17 Cre (umol / L) 66.48±13.54 66.35±11.39 65.47±12.08 65.22±12.26 Glu (mmol / L) 6.07±1.02 5.81±0.86 6.15±1.17 6.22±1.27 TC (mmol / L) 5.49±1.12 5.51±1.18 5.33±1.15 5.28±1.13 TG (mmol / L) 1.55±0.84 1.53±0.81 1.63±0.84 1.55±0.82 Urine routine Basically normal Basically normal Basically normal Basically normal Stool routine Basically normal Basically normal Basically normal Basically normal Basically normal

[0142] Table 11 Comparison of general conditions before and after the test

[0143]

[0144]

[0145] 3.2.2 Chest X-ray, electrocardiogram and abdominal B-ultrasound

[0146] The chest X-ray, electrocardiogram and abdominal B-ultrasound of the test group and the control group before the test are basically normal.

[0147] 3.2.3 Adverse reactions and allergic reactions after the test

[0148] Table 12 Adverse reactions and allergic reactions of the subjects in the two groups during the test

[0149]

[0150] 3.3 Dropout rate of the subjects

[0151] 110 subjects were included, 55 in the test group and 55 in the control group. Among them, 3 in the test group and 5 in the control group did not review on time at the specified time, which met the exclusion criteria of the subjects, and the effective subjects were 52 in the test group and 50 in the control group, and the dropout rates of the subjects in the test group and the control group were 5.5% and 9.1% respectively.

[0152] 4 Summary 4.1 110 subjects meeting the requirements were randomly divided into the test group and the control group, and 102 effective subjects were obtained, 52 in the test group and 50 in the control group. The control group took placebo. The total symptom score of the test group was significantly improved in self-comparison before and after the test and comparison after the test with the control groupP <0.001); After the trial, 23 cases showed effective symptom improvement, with an effective rate of 44.2%, which was significantly different from the control group. P <0.001); The visual persistence of the trial group improved significantly both before and after the trial, and after the trial compared to the control group. P <0.001), the average visual persistence of the test group increased by 11.3% after the test, which was higher than that of the control group, and the difference was statistically significant. P <0.001). There were no significant changes in visual acuity or eye usage time between the testing group and the control group before and after the trial. According to the criteria for the test method of relieving visual fatigue in Section IV of the "Methods for Testing and Evaluating the Functions of Health Foods (2023 Edition)," the results showed that the green tangerine tea in Example 3 had the effect of relieving visual fatigue.

[0154] 4.2 Chest X-rays, electrocardiograms, and abdominal ultrasounds of the test subjects were all basically normal. Before and after consuming the green tangerine tea of ​​Example 3, there were no significant changes in routine blood, urine, and stool tests, as well as blood biochemical indicators, indicating that it had no adverse effects on the health of the test subjects.

[0155] 4.3 No allergic reactions or other adverse reactions were observed during the tasting of the green tangerine tea in Example 3.

[0156] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A traditional Chinese medicine composition for relieving visual fatigue, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 0.1-1.5 parts of wolfberry, 0.05-1.47 parts of chrysanthemum, 0.02-0.5 parts of ginseng, 0.02-0.7 parts of cistanche, 0.2-1.2 parts of roselle, 0.02-0.37 parts of licorice, 7-12 parts of Pu-erh tea, and 18-25 parts of green tangerine peel.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1.2 parts wolfberry, 1.1 parts chrysanthemum, 0.2 parts ginseng, 0.5 parts cistanche, 0.9 parts roselle, 0.1 parts licorice, 20 parts green tangerine peel, and 9 parts Pu-erh tea.

3. A traditional Chinese medicine preparation, characterized in that, The traditional Chinese medicine preparation is made from the traditional Chinese medicine composition as described in any one of claims 1 or 2.

4. The traditional Chinese medicine preparation according to claim 3, characterized in that, The traditional Chinese medicine preparation was selected as a tea beverage.

5. The traditional Chinese medicine preparation according to claim 3, characterized in that, The traditional Chinese medicine preparation is obtained by placing wolfberry, chrysanthemum, ginseng, cistanche, roselle, licorice and Pu-erh tea inside the shell of a green tangerine.

6. The traditional Chinese medicine preparation according to claim 3, characterized in that, The traditional Chinese medicine preparation also contains taurine.

7. The traditional Chinese medicine preparation according to claim 3, characterized in that, The weight ratio of taurine to green tangerine is 0.08 to 0.18:

1.

8. A portable tea brewing device, characterized in that, The portable tea brewing device includes: A support plate, wherein the support plate is provided with through holes; A filter bag, the filter bag being fixed below a support plate; and the filter bag containing the traditional Chinese medicine preparation as described in any one of claims 3 to 6; A sealing sheet is attached to the upper part of the support plate and covers the through hole.

9. The portable tea brewing device according to claim 8, characterized in that, The filter screen has a pore size of 0.5–2 mm.

10. The portable tea brewing device according to claim 8, characterized in that, The support plate is made of virgin wood pulp material; The filter bag is made of virgin wood pulp material.

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