Angelica sinensis and paeonia lactiflora blood activating capsule
Through intelligent control and optimized preparation process, the problems of unstable quality of medicinal materials and low dissolution rate of effective ingredients in traditional Gui Shao Huo Xue Capsules have been solved, realizing drug release in the intestine and improving bioavailability and efficacy.
Patent Information
- Application Number
- CN202610085546.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-22
- Publication Date
- 2026-02-27
AI Technical Summary
Traditional preparation processes for Gui Shao Huo Xue Capsules suffer from problems such as unstable quality of medicinal materials, low dissolution rate of effective components, and improper drug release, which affect efficacy.
By employing intelligent control of medicinal material processing, vacuum low-temperature melting, ultrasonic extraction, spray drying, and enteric-coated capsule shell technology, the formulation and preparation process of medicinal materials are optimized to ensure the quality of medicinal materials and the full extraction and stable release of effective components.
It improves the bioavailability and efficacy of the drug, ensures the release of the drug in the intestine, reduces gastric irritation, and enhances the stability and efficacy of the capsule.
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to Guishao Huoxue Capsule. BACKGROUND
[0002] In the field of treating orthopedic diseases in traditional Chinese medicine, Guishao Huoxue Capsule shows unique potential in promoting blood circulation, unblocking collaterals, tonifying liver and kidney, and strengthening muscles and bones due to containing many traditional Chinese medicinal materials such as Angelica sinensis, Radix Paeoniae Alba, Astragalus membranaceus, etc., and is often used for treating orthopedic diseases such as fracture recovery period; however, the traditional preparation process of Guishao Huoxue Capsule has many limitations.
[0003] On the one hand, in the processing of medicinal materials, traditional processing methods such as vinegar quenching of natural copper and sanding of Drynariae Rhizoma rely on manual operation and it is difficult to precisely control parameters such as temperature and time; for example, the temperature of natural copper vinegar quenching fluctuates greatly and the penetration depth of the quenching liquid is insufficient; the fluff shedding rate is low during sanding of Drynariae Rhizoma and the loss of effective components is serious, resulting in unstable quality of medicinal materials and affecting the curative effect of the final preparation.
[0004] On the other hand, in the key steps of extraction and drying, the traditional method has low extraction efficiency and cannot fully dissolve the effective components of medicinal materials, resulting in insufficient content of effective components in the preparation; the drying process also easily destroys the activity of components, and there are problems such as uneven particle size and poor drug stability; in addition, the ordinary capsule shell cannot control the drug release site, the drug is released too early in the stomach, which not only stimulates the stomach, but also reduces the bioavailability of the drug in the intestinal tract and weakens the therapeutic effect. Therefore, it is urgent to improve and innovate the preparation process of Guishao Huoxue Capsule to improve the quality of the preparation and the clinical curative effect. SUMMARY
[0005] Therefore, the embodiments of the present application hope to provide Guishao Huoxue Capsule to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial choice.
[0006] The purpose of the present application can be achieved by the following technical measures: Guishao Huoxue Capsule is made of the following traditional Chinese medicinal materials: Angelica sinensis, Radix Paeoniae Alba, Astragalus membranaceus, Cornu Cervi Degelatinatum, Fructus Lycii, Dipsacus asper, Ramulus Cinnamomi, Semen Persicae, Solenopsis geminata, Dragon's Blood, Eupolyphaga, natural copper (calcined), Semen Brassicae, Radix Nelumbinis.
[0007] As a further preferred embodiment of the present technical solution: the weight parts of each traditional Chinese medicinal material are as follows: Angelica sinensis 12 parts, Radix Paeoniae Alba 9 parts, Astragalus membranaceus 15 parts, Cornu Cervi Degelatinatum 5 parts, Fructus Lycii 9 parts, Dipsacus asper 12 parts, Ramulus Cinnamomi 6 parts, Semen Persicae 8 parts, Solenopsis geminata 5 parts, Dragon's Blood 7 parts, Eupolyphaga 5 parts, natural copper (calcined) 7 parts, Semen Brassicae 8 parts, Radix Nelumbinis 12 parts.
[0008] As a further preferred embodiment of the present technical solution: the preparation method comprises the following steps: S1. Pre-treatment of medicinal materials: Weigh out the following ingredients according to the above weight proportions: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, deer antler glue, Lycium barbarum, Dipsacus asper, Cinnamomum cassia, Prunus persica, Scolopendra subspinipes, Daemonorops draco, Eupolyphaga sinensis, natural copper (calcined), mustard seed, and Achyranthes bidentata. Clean, wash, and dry each medicinal material except for deer antler glue to remove impurities and non-medicinal parts, ensuring the purity of the medicinal materials and laying the foundation for subsequent extraction of effective components. S2. Crushing: Crush all the dried medicinal materials except for deer antler glue into coarse powder to increase the contact area between the medicinal materials and the solvent. S3. Extraction: Place the pulverized coarse powder in the extraction equipment, add water at 8-12 times the total weight of the medicinal materials, soak for 1-2 hours, and then extract 2-3 times at 80-90℃, each extraction lasting 1-2 hours. Combine the extracts. Soaking allows the medicinal materials to fully absorb water and swell, and cyclic extraction ensures that the active ingredients are fully dissolved. S4. Concentration: After filtering the extract, concentrate it under reduced pressure to a clear paste with a relative density of 1.10-1.20 (60℃) to reduce the solvent volume and facilitate subsequent granulation operations. S5. Granulation: Mix the melted deer antler glue with the above-mentioned clear paste evenly, add an appropriate amount of excipients, make a soft material, and sieve it to make wet granules.
[0009] S6. Drying and granulation: Dry the wet granules at a temperature of 60-80℃ until the moisture content of the granules is 5%-8%, and then granulate them. S7. Encapsulation: The whole granules are encapsulated into capsule shells to make Gui Shao Huo Xue Capsules, which are then packaged.
[0010] As a further preferred embodiment of this technical solution: In step S1, the processing of natural copper (calcined) is carried out with intelligent control, wherein the natural copper is monitored in real time by infrared thermal imaging + closed-loop control to ensure that the quenching temperature fluctuation is ≤±5℃ and the quenching liquid penetration depth is ≥200μm.
[0011] As a further preferred embodiment of this technical solution: In step S1, the deer antler gelatin is melted separately with water for 15-20 minutes at a vacuum degree of -0.06MPa to -0.08MPa and a temperature of 50-60℃ using vacuum low-temperature melting technology. After melting, it is aseptically transported to other herbal extracts through pipelines to reduce the loss of active ingredients due to oxidation and ensure that it is fully integrated into the formulation system.
[0012] As a further preferred embodiment of this technical solution: in step S3, the extraction equipment adopts an ultrasonic-assisted extraction device, and ultrasonic waves with a frequency of 20-40kHz are applied during the extraction process. The cavitation effect of the ultrasonic waves further improves the extraction rate of the effective components of the medicinal materials.
[0013] As a further preferred embodiment of this technical solution: in step S4, the spray drying process adopts a pulsed feeding method with a feeding speed controlled at 15-20 mL / min, combined with a rotary atomizer and an atomization pressure of 0.3-0.5 MPa, so that the particle size distribution of the dry extract is more uniform and the stability of the capsule contents is improved.
[0014] As a further preferred embodiment of this technical solution: the excipient in S5 is one or a mixture of two of starch and dextrin, and the amount of excipient used is 10%-30% of the total weight of the granules.
[0015] As a further preferred embodiment of this technical solution: the drying in step S6 adopts vacuum freeze-drying technology, with the vacuum degree controlled at 10-30 Pa and the freezing temperature at -40℃ to -30℃, so that the wet particles are dried quickly at low temperature, thus better preserving the activity of the effective ingredients.
[0016] As a further preferred embodiment of this technical solution: the capsule shell of the Gui Shao Huo Xue Capsule is an enteric-coated capsule shell, which enables the drug to be released in the intestine, reduces irritation to the stomach, and improves the efficacy of the drug.
[0017] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: I. In this invention, Angelica sinensis and Paeonia lactiflora are the core ingredients for nourishing and activating blood, while Astragalus membranaceus is used to replenish Qi. When Qi flows smoothly, blood flows smoothly, which can effectively improve the body's Qi and blood circulation. Deer antler glue, wolfberry, and Dipsacus asper nourish the liver and kidneys. By nourishing the liver and kidneys together, the body's self-repair and nourishment capabilities can be enhanced, and tendons and bones can be strengthened. Cinnamon twig warms and unblocks the meridians. When combined with peach kernel, dragon's blood, ground beetle, and natural copper (calcined), it can dissipate blood stasis and promote local blood circulation, reducing pain and swelling. Centipede is good at unblocking the meridians and can penetrate deep into the meridians to clear stagnation. Mustard seed warms the lungs, clears phlegm, and promotes Qi circulation. Achyranthes bidentata removes blood stasis, unblocks the meridians, and guides the medicine downward to the affected area. Through the synergistic effect of multiple medicinal materials, the effects of activating blood circulation, unblocking the meridians, nourishing the liver and kidneys, and strengthening tendons and bones are achieved.
[0018] II. In terms of the preparation process, the natural copper is processed using real-time infrared thermal imaging and closed-loop control. The bone drynaria is processed by machine vision recognition and PID temperature control algorithm to improve the processing effect. The deer antler glue is processed by vacuum low-temperature melting technology to reduce the loss of components due to oxidation. Ultrasonic-assisted extraction improves the extraction rate of effective components. Spray drying uses pulsed feeding to make the particle size uniform. Vacuum freeze drying preserves the activity of components. The intelligent control of the whole process ensures stable quality.
[0019] Third, the efficacy is significant. The enteric-coated capsule shell allows the drug to be released in the intestine, reducing gastric irritation and improving bioavailability. It is suitable for orthopedic diseases such as fracture recovery period, which can improve symptoms and promote repair. Moreover, the quality is controllable and the stability is strong. Compared with traditional processes, there are innovative breakthroughs in processing, extraction and drying, which improve the dissolution rate of ingredients and efficacy.
[0020] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Further aspects, embodiments, and features of the invention will become apparent from the following detailed description, in addition to the illustrative aspects, embodiments, and features described above. Detailed Implementation
[0021] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention. Therefore, the description is considered to be exemplary in nature and not restrictive.
[0022] It is important to note that terms such as "first," "second," "symmetric," and "array" are used only to distinguish between descriptive and positional descriptions and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, features specified with terms such as "first" or "symmetric" may explicitly or implicitly include one or more of that feature; similarly, when the quantity of certain features is not limited by words such as "two" or "three," it should be noted that such features also explicitly or implicitly include one or more features. In this invention, unless otherwise explicitly specified and limited, terms such as "installation," "connection," and "fixation" should be interpreted broadly; for example, they can refer to a fixed connection, a detachable connection, or an integral molding; they can refer to a mechanical connection, a direct connection, a welding connection, or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specification and the specific circumstances.
[0023] The embodiments of the present invention will be described in detail below.
[0024] Gui Shao Huo Xue Capsules are made from the following Chinese medicinal herbs: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, deer antler glue, wolfberry, Dipsacus asper, cinnamon twig, peach kernel, centipede, dragon's blood, ground beetle, natural copper (calcined), mustard seed, and Achyranthes bidentata.
[0025] Specifically, the weight proportions of each Chinese medicinal herb are as follows: Angelica sinensis 12 parts, Paeonia lactiflora 9 parts, Astragalus membranaceus 15 parts, Cervi cornu colla 5 parts, Lycium barbarum 9 parts, Dipsacus asper 12 parts, Cinnamomum cassia 6 parts, Prunus persica 8 parts, Scolopendra subspinipes 5 parts, Draconis draco 7 parts, Eupolyphaga sinensis 5 parts, Calcined natural copper 7 parts, Mustard seed 8 parts, and Achyranthes bidentata 12 parts.
[0026] Specifically, its preparation method includes the following steps: S1. Pre-treatment of medicinal materials: Weigh out the following ingredients according to the above weight proportions: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, deer antler glue, Lycium barbarum, Dipsacus asper, Cinnamomum cassia, Prunus persica, Scolopendra subspinipes, Daemonorops draco, Eupolyphaga sinensis, natural copper (calcined), mustard seed, and Achyranthes bidentata. Clean, wash, and dry each medicinal material except for deer antler glue to remove impurities and non-medicinal parts, ensuring the purity of the medicinal materials and laying the foundation for subsequent extraction of effective components. S2. Crushing: Crush all the dried medicinal materials except for deer antler glue into coarse powder to increase the contact area between the medicinal materials and the solvent. S3. Extraction: Place the pulverized coarse powder in the extraction equipment, add water at 8-12 times the total weight of the medicinal materials, soak for 1-2 hours, and then extract 2-3 times at 80-90℃, each extraction lasting 1-2 hours. Combine the extracts. Soaking allows the medicinal materials to fully absorb water and swell, and cyclic extraction ensures that the active ingredients are fully dissolved. S4. Concentration: After filtering the extract, concentrate it under reduced pressure to a clear paste with a relative density of 1.10-1.20 (60℃) to reduce the solvent volume and facilitate subsequent granulation operations. S5. Granulation: Mix the melted deer antler glue with the above-mentioned clear paste evenly, add an appropriate amount of excipients, make a soft material, and sieve it to make wet granules.
[0027] S6. Drying and granulation: Dry the wet granules at a temperature of 60-80℃ until the moisture content of the granules is 5%-8%, and then granulate them. S7. Encapsulation: The whole granules are encapsulated into capsule shells to make Gui Shao Huo Xue Capsules, which are then packaged.
[0028] Specifically, in step S1, the processing of natural copper (calcined) is carried out using intelligent control. Natural copper is monitored in real time by infrared thermal imaging and closed-loop control to ensure that the quenching temperature fluctuation is ≤±5℃ and the quenching liquid penetration depth is ≥200μm.
[0029] Specifically, in step S1, the deer antler gelatin is melted separately with water for 15-20 minutes at a vacuum of -0.06MPa to -0.08MPa and a temperature of 50-60℃ using vacuum low-temperature melting technology. After melting, it is aseptically transported to other herbal extracts through pipelines to reduce the loss of active ingredients through oxidation and ensure that it is fully integrated into the formula system.
[0030] Specifically, in step S3, the extraction equipment uses an ultrasonic-assisted extraction device, which applies ultrasonic waves with a frequency of 20-40kHz during the extraction process. The cavitation effect of the ultrasonic waves further improves the extraction rate of the effective components of the medicinal materials.
[0031] Specifically, in step S4, the spray drying process adopts a pulsed feeding method with a feeding speed controlled at 15-20 mL / min, combined with a rotary atomizer and an atomization pressure of 0.3-0.5 MPa, which makes the particle size distribution of the dry extract more uniform and improves the stability of the capsule contents.
[0032] Specifically, the excipient in S5 is one or a mixture of two of starch and dextrin, and the amount of excipient used is 10%-30% of the total weight of the granules.
[0033] Specifically, in step S6, vacuum freeze-drying technology is used, with the vacuum degree controlled at 10-30 Pa and the freezing temperature at -40°C to -30°C, so that the wet particles are dried quickly at low temperature, thus better preserving the activity of the active ingredients.
[0034] Specifically, the capsule shell of the Gui Shao Huo Xue Capsules is an enteric-coated capsule shell, which allows the drug to be released in the intestines, reducing irritation to the stomach and improving the drug's efficacy.
[0035] The following are several specific embodiments of the application of the present invention. Example 1 The following medicinal materials were weighed out according to weight: 12 parts Angelica sinensis, 9 parts Paeonia lactiflora, 15 parts Astragalus membranaceus, 5 parts deer antler glue, 9 parts Lycium barbarum, 12 parts Dipsacus asper, 6 parts Cinnamomum cassia, 8 parts Prunus persica, 5 parts Scolopendra subspinipes, 7 parts Daemonorops draco, 5 parts Eupolyphaga sinensis, 7 parts calcined natural copper, 3 parts Mustard seed, and 12 parts Achyranthes bidentata. The natural copper was treated using a traditional artificial vinegar quenching method, and the deer antler glue was melted in boiling water at 100℃. All medicinal materials except the deer antler glue were pulverized, and water (8 times the total weight of the medicinal materials) was added. The mixture was extracted twice at 80℃ for 2 hours each time, without the use of ultrasonic extraction. The extract was filtered, concentrated under reduced pressure, and then mixed with the melted deer antler glue. Starch (20% of the total weight of the granules) was then added to granulate the mixture. The wet granules were dried under hot air at 80℃ until the moisture content dropped to 8%. Finally, the granules were sized and encapsulated in ordinary capsule shells.
[0036] Example 2 The following medicinal materials were weighed out according to weight: 12 parts Angelica sinensis, 9 parts Paeonia lactiflora, 15 parts Astragalus membranaceus, 5 parts deer antler glue, 9 parts Lycium barbarum, 12 parts Dipsacus asper, 6 parts Cinnamomum cassia, 8 parts Prunus persica, 6 parts Scolopendra subspinipes, 4 parts Draconis blood, 5 parts Eupolyphaga sinensis, 7 parts natural copper, 5 parts mustard seed, and 12 parts Achyranthes bidentata. In the processing stage, infrared thermal imaging was used for real-time monitoring combined with a closed-loop control system to quench the natural copper in vinegar, precisely controlling temperature fluctuations within ±5℃ to ensure the quenching solution penetrated to a depth of 210μm. The deer antler glue was vacuum-melted at -0.07MPa vacuum and 55℃ for 18 minutes. After melting, the extract is transported aseptically for 1 minute. During extraction, an ultrasonic-assisted extraction device with a frequency of 30 kHz is used, and water with a total weight of 10 times is added. The extract is circulated and extracted twice at 85°C, with each extraction lasting 1.5 hours. The concentrated extract is spray-dried using a pulsed feeding method (feeding speed 18 mL / min) at an atomization pressure of 0.4 MPa. During granulation, a mixture of starch and dextrin excipients with a total weight of 15% is added. The wet granules are then freeze-dried under vacuum (vacuum degree 20 Pa, temperature -35°C), and finally granulated and filled into enteric-coated capsule shells.
[0037] Testing revealed that the astragaloside A content in the capsules obtained in Example 1 was 0.65 mg / g, the loss rate of the effective components of Drynaria fortunei reached 8%, the particle size distribution was uneven, and the drug began to be released in gastric juice. In contrast, in Example 2, the astragaloside A content was increased to 1.02 mg / g, the particle size uniformity was good, the drug release rate in gastric juice was less than 5% after 2 hours, and the release rate in the intestine reached 92% after 4 hours. The retention rate of the effective components and the stability of the drug were significantly improved.
[0038] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.
Claims
1. Guishao Huoxue Capsules, characterized in that, It is made of the following Chinese herbal medicines: Angelica sinensis, Radix Paeoniae Alba, Astragalus membranaceus, Cornu Cervi Degelatinatum, Lycium barbarum, Dipsacus asper, Ramulus Cinnamomi, Semen Persicae, Solenopsis araneoides, Sanguis Draconis, Eupolyphaga, Natura Cuprum (calcined), Semen Brassicae, Radix Nelumbinis.
2. The Guishao Huoxue capsule according to claim 1, characterized in that The weight parts of each Chinese herbal medicine are as follows: Angelica sinensis 12 parts, Radix Paeoniae Alba 9 parts, Astragalus membranaceus 15 parts, Cornu Cervi Degelatinatum 5 parts, Lycium barbarum 9 parts, Dipsacus asper 12 parts, Ramulus Cinnamomi 6 parts, Semen Persicae 8 parts, Solenopsis araneoides 5 parts, Sanguis Draconis 7 parts, Eupolyphaga 5 parts, Natura Cuprum (calcined) 7 parts, Semen Brassicae 8 parts, and Radix Nelumbinis 12 parts.
3. The Guishao Huoxue capsule of claim 1, characterized in that, The preparation method comprises the following steps: S1, pretreatment of medicinal materials: weigh Angelica sinensis, Radix Paeoniae Alba, Astragalus membranaceus, Cornu Cervi Degelatinatum, Lycium barbarum, Dipsacus asper, Ramulus Cinnamomi, Semen Persicae, Solenopsis araneoides, Sanguis Draconis, Eupolyphaga, Natura Cuprum (calcined), Semen Brassicae, and Radix Nelumbinis according to the above weight parts, respectively clean, wash, and dry each medicinal material except Cornu Cervi Degelatinatum, remove impurities and non-medicinal parts, and ensure the purity of the medicinal materials to lay a foundation for subsequent extraction of effective components; S2, crushing: crush each medicinal material except Cornu Cervi Degelatinatum after drying into coarse powder to increase the contact area between the medicinal materials and the solvent; S3, extraction: place the crushed coarse powder into an extraction device, add 8-12 times the weight of water to the medicinal materials, soak for 1-2 hours, then extract at 80-90 ℃ for 2-3 times, each time for 1-2 hours, and combine the extraction liquid; soaking makes the medicinal materials swell by absorbing water, and cyclic extraction ensures that the effective components are fully dissolved; S4, concentration: filter the extraction liquid, and concentrate it under reduced pressure to a clear paste with a relative density of 1.10-1.20 (60 ℃), which reduces the volume of the solvent and facilitates subsequent granulation operations; S5, granulation: mix the melted Cornu Cervi Degelatinatum with the above clear paste, add an appropriate amount of excipients, make soft material, sieve, and make wet granules; S6, drying and granulation: dry the wet granules, control the drying temperature to be 60-80 ℃, dry the granules to a water content of 5%-8%, then granulate; S7, capsule filling: fill the granules after granulation into a capsule shell to make Guishao Huoxue Capsules, and then package.
4. The Guishao Huoxue capsule of claim 1, characterized in that, In S1, the processing of Natura Cuprum (calcined) is controlled intelligently, in which infrared thermal imaging real-time monitoring + closed-loop control is used to ensure that the temperature fluctuation of vinegar quenching is ≤±5 ℃ and the penetration depth of the quenching liquid is ≥200 μm.
5. The Guishao Huoxue capsule according to claim 3, characterized in that, In S1, Cornu Cervi Degelatinatum is melted by vacuum low-temperature melting technology at a vacuum degree of-0.06 MPa to-0.08 MPa and a temperature of 50-60 ℃ for 15-20 minutes, then is transferred to the extraction liquid of other medicinal materials through a sterile pipeline to reduce the oxidation loss of effective components and ensure that it is fully integrated into the formula system.
6. The Guishao Huoxue capsule according to claim 3, characterized in that, In S3, the extraction device is an ultrasonic-assisted extraction device, which applies ultrasonic waves with a frequency of 20-40 kHz during the extraction process to further improve the extraction rate of effective components of the medicinal materials.
7. The Guishao Huoxue capsule according to claim 3, characterized in that, In S4, the spray drying process adopts a pulse feeding method, the feeding speed is controlled at 15-20 mL / min, a rotary atomizer is used, and the atomization pressure is 0.3-0.5 MPa, so that the particle size distribution of the dry extract granules is more uniform and the stability of the capsule content is improved.
8. The Guishao Huoxue capsule of claim 1, characterized in that, The auxiliary material in S5 is one or mixture of starch and dextrin, and the amount of auxiliary material is 10%-30% of the total weight of granules.
9. The Guishao Huoxue capsule according to claim 1, characterized in that: The drying in S6 adopts vacuum freeze-drying technology, the vacuum degree is controlled at 10-30 Pa, and the freezing temperature is-40 ℃ to-30 ℃, so that the wet granules are quickly dried at low temperature, and the activity of the active ingredients is better preserved.
10. The Guishao Huoxue capsule according to claim 1, characterized by: The capsule shell of Guishao Huoxue Capsules is an enteric capsule shell, which can release the drug in the intestinal tract, reduce the irritation to the stomach, and improve the therapeutic effect of the drug.