Ligustrum lucidum traditional Chinese medicine composition for nourishing liver and kidney and improving eyesight and preparation method thereof
Patent Information
- Application Number
- CN202610050583.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-15
- Publication Date
- 2026-02-27
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a female privet fruit traditional Chinese medicine composition for nourishing liver and kidney and improving eyesight and a preparation method thereof. BACKGROUND
[0002] Female privet fruit (scientific name: Ligustrum lucidum Ait.) is a dried mature fruit of Ligustrum lucidum in Oleaceae and is a commonly used traditional Chinese medicine for nourishing in traditional Chinese medicine. According to traditional Chinese medicine theory, female privet fruit tastes sweet and bitter, is cold in nature, and is related to liver and kidney channels. The core effect is to nourish liver and kidney and improve eyesight and hair, and female privet fruit can be used for liver and kidney yin deficiency syndrome, such as dizziness and tinnitus, soreness and weakness of waist and knees, early graying of hair, dim eyesight, internal heat and polydipsia. Modern pharmacological research shows that female privet fruit contains oleanolic acid, ligustrazine and other active ingredients, and has the effects of antioxidant, anti-aging, enhancing immunity, protecting liver and improving eyesight.
[0003] The existing traditional Chinese medicine preparation or health composition taking female privet fruit as the main raw material has the following technical problems: 1. The synergistic effect of medicinal materials is not fully exerted. In most formulas, the ratio of female privet fruit and other medicinal materials lacks scientific optimization, or simply relies on the single effect of female privet fruit, and does not form synergistic effect combined with complementary medicinal materials, so that the core effects of nourishing liver and kidney and improving eyesight and hair cannot be maximized; 2. The effect of the formula is relatively single. Most existing products focus on the single function of 'improving eyesight' or 'darkening hair', ignoring the chain problems such as deficiency of qi and blood, weakness of spleen and stomach and restlessness of heart spirit which are often accompanied by liver and kidney deficiency, and it is difficult to achieve comprehensive regulation of the whole body; 3. The coverage of the target population is limited. Some formulas are prone to cause burden of spleen and stomach due to the partial greasy nature or unbalanced ratio, and are not suitable for people with liver and kidney deficiency and weak spleen and stomach, especially limiting the widespread use of the elderly.
[0004] Therefore, it is urgent to develop a multi-purpose traditional Chinese medicine composition based on female privet fruit with scientific ratio, comprehensive effect, strong synergistic effect and wide adaptation to the target population, so as to solve the above technical defects. SUMMARY
[0005] The technical problem to be solved by the present application is to provide a female privet fruit traditional Chinese medicine composition for nourishing liver and kidney and improving eyesight and a preparation method thereof, so as to overcome the defects and deficiencies of the prior art and products as described in the background.
[0006] The technical scheme adopted by the present application to solve the technical problem is that the female privet fruit traditional Chinese medicine composition comprises a basic core component, and the basic core component comprises female privet fruit 15-25 parts, medlar 8-15 parts, cuscuta 6-12 parts, chrysanthemum 5-10 parts, angelica 5-10 parts, white peony root 5-10 parts, Chinese yam 5-10 parts, poria 5-10 parts and licorice 3-6 parts by weight.
[0007] Further, the Schisandra chinensis traditional Chinese medicine composition further comprises a supplementary synergistic component, the supplementary synergistic component comprises, by weight: 5-8 parts of Astragalus, 3-6 parts of Ophiopogon, 2-5 parts of Ganoderma lucidum, 3-6 parts of mulberry, 3-6 parts of prepared Radix Polygoni Multiflori, 3-6 parts of Suanzaoren, 3-5 parts of Dendrobium.
[0008] Preferably, the weight parts of the basic core component are: 20 parts of Schisandra chinensis, 12 parts of Medlar, 8 parts of Semen Nelumbinis, 6 parts of Chrysanthemum, 6 parts of Angelica, 6 parts of White Peony Root, 7 parts of Chinese Yam, 7 parts of Poria cocos, and 6 parts of Licorice.
[0009] Preferably, the weight parts of the basic core component and the supplementary synergistic component are: 20 parts of Schisandra chinensis, 12 parts of Medlar, 8 parts of Semen Nelumbinis, 6 parts of Chrysanthemum, 6 parts of Angelica, 6 parts of White Peony Root, 5 parts of Chinese Yam, 5 parts of Poria cocos, 4 parts of Licorice, 6 parts of Astragalus, 4 parts of Ophiopogon, 3 parts of Ganoderma lucidum, 4 parts of mulberry, 4 parts of prepared Radix Polygoni Multiflori, 4 parts of Suanzaoren, and 3 parts of Dendrobium.
[0010] The application also discloses an application of the Schisandra chinensis traditional Chinese medicine composition, which is used to prepare a preparation for regulating liver and kidney deficiency, improving eyesight, tonifying Qi and blood, invigorating spleen and stomach, and / or soothing nerves and helping sleep, and the preparation is in the form of granules, pills, a decoction or a paste.
[0011] The application also discloses a preparation method of the Schisandra chinensis traditional Chinese medicine composition. a. raw material pretreatment: each medicinal material is weighed according to weight parts, when preparing granules, a decoction or a paste, each medicinal material is crushed into 80-100 mesh coarse powder, and then is uniformly mixed; when preparing pills, Chinese Yam is steamed and mashed into Chinese Yam paste, and the rest of the medicinal materials are crushed into 100-120 mesh powder, and then are uniformly mixed to obtain fine powder; b. extraction (for granules, a decoction and a paste): 8-12 times the amount of purified water based on the total mass of the medicinal materials is added to the uniformly mixed powder, is soaked for 30-60 minutes, is heated and decocted for 1.5-2 hours, is filtered to obtain a first extraction liquid; 6-8 times the amount of purified water based on the total mass of the medicinal materials is added to the residue, is decocted again for 1-1.5 hours, is filtered to obtain a second extraction liquid; the two obtained extraction liquids are combined, and the supernatant is taken after standing; c. Forming: adopt corresponding process according to target dosage form: for granules: concentrate supernatant under reduced pressure to clear paste with relative density 1.20-1.25 (60℃), add dextrin with weight 1-1.5 times of clear paste, mix uniformly, spray dry (inlet air temperature 160-180℃, outlet air temperature 80-90℃), then granulate, add magnesium stearate with 0.5-1% of total mass of dried granules, mix and subpack; for pills (without performing step b, directly use pretreatment product of step a): mix obtained medicinal material fine powder with yam paste, then add honey with 30%-40% of total weight of medicinal material to make pills, dry at 40-50℃ until moisture≤15%, then polish and subpack; for decoction: according to use scenario: in present decocting and present taking scenario, directly subpack supernatant; in commercialized storage scenario, first perform pasteurization (70-80℃, 15-20 minutes) to supernatant, then subpack after cooling; for paste: concentrate supernatant, then add rock sugar or honey to collect paste, subpack after concentrating to relative density 1.30-1.35 (60℃).
[0012] Compared with existing similar products, the beneficial effects of the present application are: 1. Significant synergistic effect and strong comprehensive conditioning ability: taking female privet fruit as core, a multi-dimensional conditioning system of "tonifying liver and kidney, brightening eyes and hair, tonifying qi and blood, invigorating spleen and stomach, and tranquilizing mind and sleeping" is constructed; female privet fruit, together with medlar fruit and dodder seed, synergistically enhances the effects of tonifying liver and kidney and benefiting essence and brightening eyes; in combination with chrysanthemum, "tonifying + purging" balance is achieved, which not only nourishes liver yin but also purges liver and brightens eyes, improving dim eyes and visual fatigue; angelica and white peony root, together with female privet fruit, synergistically nourish blood, solving the problem of deficiency of liver and kidney accompanied by deficiency of qi and blood; yam and poria cocos invigorate spleen and stomach, avoiding the problem of female privet fruit increasing the burden of spleen and stomach due to its property of causing dampness; in addition, astragalus and ganoderma lucidum in the formula enhance immunity and anti-aging, and semen ziziphi spinosae tranquilizes mind and sleeping, realizing comprehensive conditioning of the whole body; 2. Scientific proportioning and wide application to people: by optimizing the weight percentage of each medicinal material, the cold and hot property and the degree of dampness are balanced, which not only ensures the core tonifying effect but also reduces the burden of spleen and stomach, and is suitable for people with sub-health conditions such as deficiency of liver and kidney, decreased vision, early graying of hair, deficiency of qi and blood, weakness of spleen and stomach, insomnia and anxiety, and low immunity, especially for the elderly and people with liver and kidney yin deficiency caused by long-term eye use and staying up late. 3. Natural and safe raw materials: pure natural Chinese medicinal materials are used as raw materials, and there is no chemical additive, after the property is adjusted by liquorice, the irritability is extremely low, which can be used for long-term conditioning and is suitable for people with different constitutions. DETAILED DESCRIPTION
[0013] The application will be further described by the following examples. The described examples are only part of the examples of the application, but not all the examples.
[0014] Example 1: A lycium barbarum traditional Chinese medicine composition, comprising a basic core component, the basic core component comprising, by weight fraction: lycium barbarum 15-25 parts, medlar 8-15 parts, semen cuscutae 6-12 parts, chrysanthemum 5-10 parts, angelica 5-10 parts, white peony root 5-10 parts, Chinese yam 5-10 parts, tuckahoe 5-10 parts, and licorice 3-6 parts.
[0015] The most preferred ratio is: lycium barbarum 20 parts, medlar 12 parts, semen cuscutae 8 parts, chrysanthemum 6 parts, angelica 6 parts, white peony root 6 parts, Chinese yam 7 parts, tuckahoe 7 parts, and licorice 6 parts.
[0016] The efficacy and synergistic effect of each component of the basic core component are as follows: Lycium barbarum: core component, nourishing liver and kidney, darkening eyes and hair, and resisting oxidation and aging, laying the foundation for the core efficacy of "nourishing liver and kidney" of the formula; Medlar: nourishing liver and kidney, benefiting essence and eyesight, and enhancing immunity, synergistically strengthening the efficacy of nourishing liver and kidney with lycium barbarum, and simultaneously improving the body's resistance; Semen cuscutae: tonifying kidney and essence, nourishing liver and eyesight, and being neutral and not drying, assisting lycium barbarum and medlar in nourishing liver and kidney, and improving soreness and weakness of waist and knees, and dim eyesight; Chrysanthemum: clearing liver and eyesight, and dispersing wind-heat, forming a synergy of "nourishing liver + clearing liver" with lycium barbarum, both nourishing liver yin and clearing liver fire, and improving redness and swelling of eyes, and visual fatigue caused by liver fire; Angelica: tonifying blood and regulating menstruation, and providing nourishment for blood deficiency caused by liver and kidney deficiency, and achieving "tonifying liver and kidney together, and tonifying blood together" with lycium barbarum; White peony root: tonifying blood and regulating menstruation, and soothing liver and relieving pain, assisting angelica in enhancing the efficacy of tonifying blood, and simultaneously relieving stiffness and pain of limbs caused by liver and kidney yin deficiency; Chinese yam: tonifying spleen and kidney, nourishing stomach and generating fluid, neutralizing the greasy nature of lycium barbarum, avoiding abdominal distension and indigestion in people with weak spleen and stomach after taking, and improving the adaptability of the formula; Tuckahoe: tonifying spleen and kidney, soothing the heart and calming the nerves, and regulating the spleen and stomach with Chinese yam, simultaneously relieving restlessness caused by liver and kidney deficiency, and assisting in improving sleep; Licorice: regulating the properties of various drugs, reducing the overall irritability of the formula, enhancing the synergistic effect of various drugs, and improving the safety of taking.
[0017] Example 2: On the basis of embodiment 1, a supplementary synergistic component is added, which includes, by weight: 5-8 parts of Huangqi, 3-6 parts of Maidong, 2-5 parts of Lingzhi, 3-6 parts of Sangshen, 3-6 parts of Shuifuxie, 3-6 parts of Suanzaoren, 3-5 parts of Shihua. The most preferred ratio of the base core component and the supplementary synergistic component is: 20 parts of Nuzhizi, 12 parts of Gouqi, 8 parts of Tusizi, 6 parts of Juhe, 6 parts of Dangui, 6 parts of Baishao, 5 parts of Shanyao, 5 parts of Fuling, 4 parts of Gancao, 6 parts of Huangqi, 4 parts of Maidong, 3 parts of Lingzhi, 4 parts of Sangshen, 4 parts of Shuifuxie, 4 parts of Suanzaoren, 3 parts of Shihua.
[0018] The effects and synergies of the components of the supplementary synergistic component are as follows: Huangqi: tonifying qi, strengthening immunity, promoting water excretion and reducing swelling, synergizes with Dangui to achieve "tonifying qi and nourishing blood", enhancing the body's anti-fatigue and anti-aging ability, and strengthening the nourishing effect of the formula; Maidong: nourishing yin and generating fluid, moistening the lungs and clearing the heart, synergizes with Nuzhizi to nourish yin fluid, improving dry mouth, dry tongue, and internal heat caused by liver and kidney yin deficiency, while also assisting in calming the mind; Lingzhi: tonifying qi and nourishing blood, calming the heart and soothing the mind, enhancing immunity, synergizes with Suanzaoren to improve insomnia and anxiety, improving sleep quality, while enhancing the body's resistance and delaying aging; Sangshen: nourishing yin and blood, generating fluid and moistening dryness, synergizes with Nuzhizi and Shuifuxie to nourish the liver and kidney, benefit the essence and blood, and strengthen the hair-nourishing and beauty-enhancing effects, while also improving constipation caused by yin deficiency; Shuifuxie: tonifying liver and kidney, benefiting essence and blood, and darkening hair, synergizes with Nuzhizi to enhance the nourishing effect of the liver and kidney, and specifically improve early graying and soreness of the waist and knees; Suanzaoren: nourishing the heart and liver, calming the mind and soothing the spirit, synergizes with Fuling and Lingzhi to significantly improve the sleep-inducing and sleep-aiding effects of the formula, and improve insomnia, dreams, and easy waking caused by liver and kidney deficiency; Shihua: benefiting the stomach, generating fluid, nourishing yin and clearing heat, synergizes with Shanyao and Fuling to regulate the spleen and stomach, while also enhancing the yin-nourishing effect and relieving symptoms of yin deficiency and dry heat.
[0019] Embodiment 3: The Nuzhizi traditional Chinese medicine composition prepared according to the most preferred ratio of embodiment 2 is prepared into granules, with the following steps: Step 1: raw material pretreatment: each medicinal material is crushed into 80-100 mesh coarse powder, and then mixed uniformly to obtain a mixed coarse powder; Step 2: extraction: 8-12 times the amount of purified water based on the total mass of the medicinal materials is added to the mixed coarse powder, soaked for 30-60 minutes, then heated to boiling and maintained at a gentle boil for 1.5-2 hours, filtered to obtain the first extraction liquid; 6-8 times the amount of purified water based on the total mass of the medicinal materials is added to the residue, and again boiled gently for 1-1.5 hours, filtered to obtain the second extraction liquid; the two extraction liquids are combined, and the supernatant is taken after standing for 24 hours; Step 3: Concentration and drying: The supernatant is placed in a vacuum concentration tank and concentrated at 60-70℃ and 0.06-0.08 MPa to a relative density of 1.20-1.25 (60℃) clear paste; an appropriate amount of dextrin (clear paste:dextrin weight ratio of 1:1-1:1.5) is added, mixed uniformly, and then spray dried (inlet air temperature of 160-180℃ and outlet air temperature of 80-90℃) to obtain dry granules; Step 4: Forming: The dry granules are sieved through a 12-14 mesh screen to size, 0.5-1% magnesium stearate based on the total mass of the dry granules is added and mixed uniformly, and then the granules are packaged to obtain granules.
[0020] Notes on the addition of magnesium stearate: 1. The addition time must be strictly controlled after sizing to avoid premature addition affecting the granulation effect; 2. Equal incremental mixing is required to ensure uniform dispersion of magnesium stearate in the granules to prevent local concentration from affecting the dissolution efficiency of the preparation; 3. The dosage must be accurately controlled at 0.5-1% (based on the total mass of the dry granules), and excessive addition may cause excessive flowability of the granules or affect the dissolution of the active ingredients, and insufficient addition may not achieve the desired lubrication effect; 4. Pharmaceutical-grade magnesium stearate meeting the standards of the People's Republic of China Pharmacopoeia is selected to ensure the purity of the raw material and avoid introducing impurities that affect the safety of the preparation.
[0021] Example 4: The female ginseng traditional Chinese medicine composition prepared according to the optimal formulation of Example 2 is prepared into pills, and the steps are as follows: Step 1: Raw material pretreatment: the yam is steamed separately and mashed into yam paste, and the remaining medicinal materials are separately pulverized to 100-120 mesh and then mixed uniformly to obtain medicinal powder; Step 2: Pill making: the medicinal powder and yam paste are mixed, an appropriate amount of honey (30-40% of the total weight of the medicinal materials) is added as a binder, and kneaded into a soft and hard medicinal mass. After standing for 20-30 minutes, the honey pills with a diameter of 3-5 mm are prepared using a pill machine; Step 3: Drying and packaging: the honey pills are placed in a well-ventilated and dry place and dried at 40-50℃ to a moisture content of ≤15%, polished, and then packaged to obtain pills.
[0022] Example 5: The female ginseng traditional Chinese medicine composition prepared according to the optimal formulation of Example 2 is prepared into a decoction, and the steps are as follows: Step 1: Raw material pretreatment: each medicinal material is separately pulverized to 80-100 mesh coarse powder, and then mixed uniformly to obtain mixed coarse powder; Step 2: Extraction: 8-12 times the amount of purified water based on the total mass of the medicinal materials is added to the mixed coarse powder, soaked for 30-60 minutes, heated to boiling and kept at a gentle boil for 1.5-2 hours, and filtered to obtain the first extraction liquid; 6-8 times the amount of purified water based on the total mass of the medicinal materials is added to the residue, and gentle boiling is performed again for 1-1.5 hours, and filtered to obtain the second extraction liquid; the two extraction liquids are combined, and the supernatant is taken after standing for 24 hours; Step 3: Forming and packaging: according to the use scenario, the subsequent process is selected: ① present decoction present service scenario: the supernatant is directly packaged, and the decoction is obtained, which needs to be consumed within 24-48 hours; ② commercial preservation scenario: the supernatant is placed in a sterilization device, and a pasteurization process (70-80℃, constant temperature for 15-20 minutes) is adopted, and after sterilization, it is quickly cooled to room temperature, and then sterile packaging is performed, and sealed preservation is performed; Decoction preparation matters needing attention: 1. The pasteurization temperature needs to be strictly controlled at 70-80℃, avoiding high temperature (>90℃) to destroy the heat-sensitive effective components such as ligustrazine and oleanolic acid; 2. Commercial packaging needs to be carried out in a sterile environment, and the container needs to be sterilized to prevent secondary pollution.
[0023] Example 6: The Ligustrum lucidum traditional Chinese medicine composition prepared according to the optimal ratio of Example 2 is prepared into a paste, and the steps are as follows: Step 1: Raw material pretreatment: each medicinal material is crushed into 80-100 mesh coarse powder, and then mixed uniformly to obtain mixed coarse powder; Step 2: Extraction: 8-12 times the amount of purified water based on the total mass of the medicinal materials is added to the mixed coarse powder, soaked for 30-60 minutes, heated to boiling and kept at a gentle boil for 1.5-2 hours, and filtered to obtain the first extraction liquid; 6-8 times the amount of purified water based on the total mass of the medicinal materials is added to the residue, and gentle boiling is performed again for 1-1.5 hours, and filtered to obtain the second extraction liquid; the two extraction liquids are combined, and the supernatant is taken after standing for 24 hours; Step 3: Concentration and paste collection: the supernatant is placed in a double-layer pot, first heated to concentrate to a relative density of 1.10-1.15 (60℃), then 50-60% of the total weight of the medicinal materials is added to the ice sugar or honey, stirred and dissolved, and then continued to concentrate to a relative density of 1.30-1.35 (60℃), and the paste is prevented from sticking to the bottom by constant stirring; Step 4: Packaging and sterilization: the concentrated paste is hot packaged into clean brown glass bottles, sealed, and then sterilized by flow steam sterilization (100℃, 30 minutes), and the paste is obtained after cooling.
[0024] The Ligustrum lucidum traditional Chinese medicine composition of the present application realizes multi-dimensional regulation and cooperation through the design logic of "core nourishment + synergistic complementation + harmonization and adaptation": 1. Liver and kidney tonification, black hair and eyesight improvement: The synergistic effect of female ginseng fruit, medlar fruit, Chinese milkvetch seed and prepared rehmannia root precisely targets the core pathogenesis of liver and kidney deficiency, strengthens the effects of nourishing liver and kidney and nourishing essence and marrow, and effectively improves early graying, soreness of waist and knees, and dim eyesight. 2. Blood and qi tonification, anti-aging and immunity enhancement: Angelica sinensis and white peony root nourish blood, Astragalus membranaceus tonifies qi, and the antioxidant components of Ganoderma lucidum and female ginseng fruit achieve the effect of "nourishing blood and qi simultaneously and regulating the inside and outside", and enhance the body's immunity, anti-fatigue and anti-aging ability. 3. Spleen and stomach regulation, wide adaptation: Chinese yam, Poria cocos and dendrobium regulate the spleen and stomach, and licorice root adjusts the medicinal properties and neutralizes the greasy nature of the core medicinal materials, solves the defect of traditional tonifying formula that easily damages the spleen and stomach, and expands the applicable population. 4. Mind and body regulation, sleep improvement: The synergistic effect of Suanzaoren, Poria cocos, Ganoderma lucidum and Ophiopogon japonicus targets the restlessness of mind caused by liver and kidney deficiency and blood and qi deficiency, achieves the chain regulation of "nourishing liver and kidney, tonifying blood and qi, and calming the mind", and improves sleep quality.
[0025] The following gives several typical cases for application verification: Case 1: (liver and kidney deficiency type visual impairment) Patient: Ms. Chen, 42 years old, long-term desk work, visual impairment, dry eyes and photophobia for nearly 1 year, accompanied by dizziness, tinnitus, soreness of waist and knees, and TCM syndrome of liver and kidney deficiency and eyesight deficiency.
[0026] Effect of taking: Take the female ginseng fruit traditional Chinese medicine composition granules prepared by the application, take daily, after 1 month, the symptoms of dry eyes and photophobia are significantly relieved, and the visual impairment is improved; continuously take for 3 months, dizziness, tinnitus, soreness of waist and knees disappear, and the visual acuity returns to normal level, and the eye fatigue during work is significantly reduced.
[0027] Case 2: (early graying with blood and qi deficiency) Patient: Mr. Zhang, 50 years old, the hair and beard have gradually turned white for nearly 3 years, accompanied by pale face, fatigue, insomnia and dreaminess, and TCM syndrome of liver and kidney deficiency and blood and qi deficiency.
[0028] Effect of taking: Take the female ginseng fruit traditional Chinese medicine composition prepared by the application, take daily, after 1 month, the fatigue and fatigue are relieved, and the sleep quality is improved; continuously take for 6 months, the face is ruddy, the newly born hair black pigment deposition increases, the growth rate of white hair is significantly slowed down, and the overall mental state is significantly improved.
[0029] Case 3: (menopausal syndrome (liver and kidney deficiency type)) Patient: Ms. Liu, 53 years old, menopause for 1 year, accompanied by hot flashes, night sweats, irritability, dizziness, insomnia, soreness of waist and knees, and TCM syndrome of liver and kidney deficiency and yin and yang imbalance.
[0030] Taking effect: After taking the Ligustri Lucidi Fructus traditional Chinese medicine composition prepared by the application for 1 month, the frequency of hot flashes and night sweats is reduced, and the mood is gradually stabilized; after taking it continuously for 2 months, insomnia, dizziness, and soreness of waist and knees are basically disappeared, menopausal discomfort is effectively relieved, and the quality of life is significantly improved.
[0031] Case 4: (spleen and stomach weakness accompanied by liver and kidney deficiency) Patient: Mr. Zhao, 65 years old, long-term spleen and stomach weakness, appeared soreness of waist and knees, loss of appetite, abdominal distension and loose stool for half a year, accompanied by blurred vision, TCM syndrome is liver and kidney deficiency, spleen and stomach weakness.
[0032] Taking effect: After taking the Ligustri Lucidi Fructus traditional Chinese medicine composition prepared by the application for 1 month, the frequency of hot flashes and night sweats is reduced, and the mood is gradually stabilized; after taking it continuously for 2 months, insomnia, dizziness, and soreness of waist and knees are basically disappeared, menopausal discomfort is effectively relieved, and the quality of life is significantly improved.
[0033] The above examples are only used to explain the present application, and are not limited to the protection of the present application. Any non-substantial modification based on the essential scheme of the present application shall fall within the protection scope of the present application.
Claims
1. A traditional Chinese medicine composition containing Ligustrum lucidum, characterized in that: It includes basic core components, which, by weight, include: 15-25 parts of privet fruit, 8-15 parts of wolfberry fruit, 6-12 parts of dodder seed, 5-10 parts of chrysanthemum, 5-10 parts of angelica root, 5-10 parts of white peony root, 5-10 parts of yam, 5-10 parts of poria cocos, and 3-6 parts of licorice root.
2. The privet fruit traditional Chinese medicine composition according to claim 1, characterized in that: It also includes supplementary synergistic components, which, by weight, include: 5-8 parts Astragalus membranaceus, 3-6 parts Ophiopogon japonicus, 2-5 parts Ganoderma lucidum, 3-6 parts Morus alba, 3-6 parts processed Polygonum multiflorum, 3-6 parts Ziziphus jujuba var. spinosa, and 3-5 parts Dendrobium nobile.
3. The privet fruit traditional Chinese medicine composition according to claim 1, characterized in that: The weight proportions of the basic core components are as follows: 20 parts of privet fruit, 12 parts of wolfberry fruit, 8 parts of dodder seed, 6 parts of chrysanthemum, 6 parts of angelica root, 6 parts of white peony root, 7 parts of yam, 7 parts of poria cocos, and 6 parts of licorice root.
4. The privet fruit traditional Chinese medicine composition according to claim 2, characterized in that: The weight proportions of the basic core components and supplementary synergistic components are as follows: 20 parts of Ligustrum lucidum, 12 parts of Lycium barbarum, 8 parts of Cuscuta chinensis, 6 parts of Chrysanthemum morifolium, 6 parts of Angelica sinensis, 6 parts of Paeonia lactiflora, 5 parts of Dioscorea opposita, 5 parts of Poria cocos, 4 parts of Glycyrrhiza uralensis, 6 parts of Astragalus membranaceus, 4 parts of Ophiopogon japonicus, 3 parts of Ganoderma lucidum, 4 parts of Morus alba, 4 parts of processed Polygonum multiflorum, 4 parts of Ziziphus jujuba var. spinosa, and 3 parts of Dendrobium nobile.
5. The application of the Ligustrum lucidum traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that: This preparation is used to prepare formulations for treating liver and kidney deficiency, improving vision, replenishing qi and blood, strengthening the spleen and stomach, and / or calming the mind and aiding sleep. The dosage form of the formulation is granules, pills, decoctions, or ointments.
6. A method for preparing a formulation of the Ligustrum lucidum traditional Chinese medicine composition according to any one of claims 1 to 4: characterized in that: Includes the following steps: a. Raw material pretreatment: Weigh each medicinal material according to the stated weight proportions, and perform the following pretreatment according to the target dosage form: When preparing granules, decoctions, or pastes, pulverize each medicinal material separately to 80-100 mesh coarse powder, and then mix them evenly; when preparing pills, steam yam separately and mash it into yam paste, and pulverize the remaining medicinal materials separately to 100-120 mesh before mixing them evenly to obtain fine powder of medicinal materials; b. Extraction (applicable to granules, decoctions, and ointments): Add 8-12 times the amount of purified water based on the total mass of the medicinal materials to the mixed powdered medicinal materials, soak for 30-60 minutes, heat and decoct for 1.5-2 hours, and filter to obtain the first extract; add 6-8 times the amount of purified water based on the total mass of the medicinal materials to the filter residue, decoct again for 1-1.5 hours, and filter to obtain the second extract; combine the two extracts, let stand, and take the supernatant; c. Forming: Adopt the corresponding process according to the target dosage form: Granule preparation: Concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.20–1.25 (60℃), add 1–1.5 times the weight of the clear paste of dextrin and mix thoroughly. Spray dry (inlet air temperature 160–180℃, outlet air temperature 80–90℃), then granulate. Add 0.5–1% magnesium stearate (based on the total mass of dried granules) and mix and package. Pill preparation (step b is unnecessary; directly use the pretreated product from step a): [The text abruptly ends here, likely due to an incomplete sentence or missing information.] The obtained medicinal powder is mixed with yam paste, and then 30% to 40% of the total weight of the medicinal materials is added to make pills. After drying at 40℃ to 50℃ until the moisture content is ≤15%, the pills are polished and packaged. For preparing decoctions: depending on the usage scenario: for immediate decoction and consumption, the supernatant is directly packaged; for commercial preservation, the supernatant is first pasteurized, cooled, and then packaged. For preparing ointments: the supernatant is concentrated and then rock sugar or honey is added to make an ointment. After concentrating to a relative density of 1.30 to 1.35 (60℃), the ointment is packaged.