Pharmaceutical type vacuum freeze drying equipment

Abstract

The pharmaceutical type vacuum freeze drying equipment comprises a freezing box body, a feeding mechanism, a discharging mechanism, a vacuum pump and a separating mechanism, a feeding port is formed in one side of the freezing box body, the feeding mechanism is arranged on the feeding port, a discharging port is formed in one side of the bottom of the freezing box body, and the discharging mechanism is arranged on the discharging port. The discharging mechanism is arranged at the bottom of the freezing box body, the discharging end of the discharging mechanism is arranged on the upper side of the discharging opening, a vacuum extraction opening is formed in the upper side of the freezing box body, one end of the extraction pipeline is connected with the vacuum extraction opening, the vacuum pump is arranged on the extraction pipeline, and the separating mechanism is arranged on the vacuum extraction opening. The freeze-dried powder is effectively prevented from being pumped out by the vacuum pump, so that the waste of medicaments is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to a freeze-drying equipment, in particular to a pharmaceutical vacuum freeze-drying equipment, and belongs to the technical field of pharmaceutical equipment. BACKGROUND

[0002] Freeze-dried medicine is a kind of medicine or biological product made by freeze-drying technology, which can maintain the stability of active cost. Freeze-dried preparations are widely used in the fields of enzyme preparations, vaccines and antibiotics, etc. and are favored because of their convenience for transportation and long-term storage. During the freeze-drying process, the water in the medicine sublimates into water vapor, and in order to maintain the stability of the vacuum inside the freeze-drying equipment, a vacuum pump is needed to continuously suck and discharge the internal water vapor. The suction force of the vacuum pump is large, and most of the final products of freeze-dried medicine are powder, so the freeze-dried powder is easily sucked out of the equipment during the suction process of the vacuum pump. At present, the main method is to add filter material in the suction pipeline of the vacuum pump to block and filter the freeze-dried powder sucked out, so as to avoid its leakage into the external air, but the freeze-dried powder in the filter material is difficult to recover and is usually discarded, causing a certain waste. SUMMARY

[0003] The technical problem to be solved by the present application is to provide a pharmaceutical vacuum freeze-drying equipment which can effectively prevent freeze-dried powder from being sucked out by the vacuum pump.

[0004] To solve the above technical problems, the technical scheme adopted by the present application is: A pharmaceutical vacuum freeze-drying equipment, comprising a freezing box body, a feeding mechanism, a discharging mechanism, a vacuum pump and a separation mechanism, a feeding port is opened on one side of the freezing box body, the feeding mechanism is arranged on the feeding port, a discharging port is opened on one side of the bottom of the freezing box body, the discharging mechanism is arranged on the bottom of the freezing box body and the discharging end of the discharging mechanism is arranged on the upper side of the discharging port, a vacuum suction port is opened on the upper side of the freezing box body, one end of a suction pipeline is connected with the vacuum suction port, the vacuum pump is arranged on the suction pipeline, and the separation mechanism is arranged on the vacuum suction port.

[0005] Further, the separation mechanism comprises a separation cylinder and an inner cylinder, the lower end of the separation cylinder is in a conical structure and a discharging port is arranged at the top end of the conical structure of the lower end of the separation cylinder, the upper end of the separation cylinder is fixed to the top of the freezing box body, an air inlet pipeline is arranged on the side surface of the upper end of the separation cylinder, the air inlet pipeline is arranged along the tangential direction of the separation cylinder, the inner cylinder is arranged inside the separation cylinder and is arranged concentrically with the separation cylinder, the upper end of the inner cylinder is fixed to the top of the freezing box body, and the vacuum suction port is located at the top of the inner cylinder.

[0006] Further, the separation mechanism is provided with a freeze-dried medicine powder recovery device, which comprises an inner cylinder brush, a separation cylinder brush, a brush support, an inner cylinder gear, a separation cylinder gear, a main gear, a gear shaft, an auxiliary gear, an inner ring gear and a gear shaft circumferential driving mechanism. The inner cylinder brush and the separation cylinder brush are arranged in a vertical direction and rotatably arranged on the brush support. The inner cylinder gear is fixed on the upper end rotating shaft of the inner cylinder brush, and the separation cylinder gear is fixed on the upper end rotating shaft of the separation cylinder brush. The inner cylinder gear and the separation cylinder gear are respectively engaged with the main gear. The main gear is fixed on the lower end of the gear shaft. The auxiliary gear is fixed on the upper end of the gear shaft and engaged with the inner ring gear. The inner ring gear is fixed on the top surface of the freezer body. The gear shaft is connected with the gear shaft circumferential driving mechanism and driven to rotate along the circumferential direction of the separation cylinder body by the gear shaft circumferential driving mechanism.

[0007] Further, the gear shaft circumferential driving mechanism comprises a driving rod, an outer ring gear, a sleeve, a driving gear and a driving motor. The sleeve is sleeved outside the air exhaust pipeline and can rotate along the horizontal circumferential direction. The outer ring gear is fixed on the upper end of the sleeve. The driving gear is rotatably connected with the driving motor and driven to rotate by the driving motor. The driving gear is engaged with the outer ring gear. The driving rod is arranged in the radial direction of the outer ring gear, and one end of the driving rod is fixedly connected with the outer ring gear. The upper end of the gear shaft is rotatably arranged on the other end of the driving rod.

[0008] Further, the number of the inner cylinder brushes is two, and the number of the separation cylinder brushes is also two. The two inner cylinder brushes and the two separation cylinder brushes are distributed in a trapezoidal structure on the brush support.

[0009] Further, the feeding mechanism comprises a feeding hopper, a feeding pipeline, a spiral feeding roller and a feeding driving motor. The feeding pipeline is arranged in a horizontal direction, and one end of the feeding pipeline is connected with the feeding port on the side surface of the freezer body. The spiral feeding roller is arranged in the axial direction of the feeding pipeline and rotatably arranged in the feeding pipeline. One end of the spiral feeding roller is connected with the feeding driving motor and driven to rotate by the feeding driving motor. The other end of the feeding pipeline is connected with the discharging port of the feeding hopper.

[0010] Further, the discharging port of the feeding hopper is provided with a feeding valve, and the upper end of the feeding hopper is provided with an openable and closable cover plate.

[0011] Further, the discharging mechanism comprises a discharging main roller, a discharging auxiliary roller, a discharging conveying belt and a discharging driving motor. The discharging main roller and the discharging auxiliary roller are respectively rotatably arranged on both sides of the bottom of the freezer body. The discharging conveying belt is arranged on the discharging main roller and the discharging auxiliary roller. One end of the discharging main roller is connected with the discharging driving motor and driven to rotate by the discharging driving motor.

[0012] Further, the discharging port of the freezer body is provided with a discharging valve.

[0013] Compared with the prior art, the present application has the following advantages and effects: the present application provides a pharmaceutical vacuum freeze-drying equipment, by increasing the separation mechanism of the inner and outer cylinder structure at the vacuum air outlet, the airflow sucked forms a cyclone between the inner and outer cylinder, under the action of centrifugal force, the solid powder impacts on the inner wall of the separation cylinder and falls back into the freeze tank along the cylinder, while the air mixed with water vapor is sucked out by the vacuum pump, effectively avoiding the freeze-dried powder being sucked out by the vacuum pump, thereby reducing the waste of the medicament; the present application also provides a freeze-dried powder recovery device, by the cooperation of the gear and gear ring structure, the synchronous driving of the inner and outer rolling brushes is realized, the medicament powder on the cylinder wall is brushed off, and the medicament powder recovery efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 is a schematic diagram of a pharmaceutical vacuum freeze-drying equipment of the present application.

[0015] Figure 2 is an internal schematic diagram of the separation mechanism of the present application.

[0016] Figure 3 is a top view of the separation mechanism of the present application.

[0017] Figure 4 is a partial schematic diagram of the separation mechanism of the present application.

[0018] Figure 5 is a schematic diagram of the feeding mechanism of the present application.

[0019] Figure 6 is a schematic diagram of the discharging mechanism of the present application. DETAILED DESCRIPTION

[0020] In order to clearly and completely describe the technical solutions adopted by the present application to achieve the predetermined technical purposes, the technical solutions in the embodiments of the present application will be described in detail below with reference to the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all embodiments, and the technical means or technical features in the embodiments of the present application can be replaced without creative labor, which will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0021] As Figure 1As shown in the figure, the pharmaceutical vacuum freeze-drying equipment of the present application comprises a freezing box 1, a feeding mechanism 2, a discharging mechanism 3, a vacuum pump 4 and a separation mechanism. The freezing box 1 is provided with a feeding port on one side, and the feeding mechanism 2 is arranged on the feeding port. The freezing box 1 is provided with a discharging port on one side of the bottom, and the discharging mechanism 3 is arranged on the bottom of the freezing box 1, and the discharging end of the discharging mechanism 3 is arranged on the upper side of the discharging port. The freezing box 1 is provided with a vacuum air outlet on the upper side, and one end of an air outlet pipeline 5 is connected with the vacuum air outlet. The vacuum pump 4 is arranged on the air outlet pipeline 5, and the separation mechanism is arranged on the vacuum air outlet.

[0022] As shown in the figure, Figure 2 , Figure 3 and Figure 4 , the separation mechanism comprises a separation cylinder 6 and an inner cylinder 7. The lower end of the separation cylinder 6 is in a conical structure, and the top end of the conical structure of the lower end of the separation cylinder 6 is provided with a discharging port. The upper end of the separation cylinder 6 is fixed on the top of the freezing box 1. The separation cylinder 6 is provided with an air inlet pipeline 8 on the side surface of the upper end. The air inlet pipeline 8 is arranged along the tangential direction of the separation cylinder 6. The inner cylinder 7 is arranged inside the separation cylinder 6 and is arranged concentrically with the separation cylinder 6. The upper end of the inner cylinder 7 is fixed on the top of the freezing box 1, and the vacuum air outlet is located on the top of the inner cylinder 7.

[0023] When the vacuum pump 5 is working, the air inside the freezing box 1 is sucked into the separation cylinder 6 along the air inlet pipeline 8. The air inlet pipeline 8 is arranged along the tangential direction of the separation cylinder 6, so that the air inlet forms a spiral cyclone along the inner wall of the separation cylinder 6. The air in the cyclone is mixed with water vapor and freeze-dried powder. Since the freeze-dried powder is in a solid state, it is impacted on the inner wall of the separation cylinder 6 under the action of centrifugal force and slows down. Finally, the freeze-dried powder falls along the inner wall of the separation cylinder 6 and returns to the freezing box 1 from the discharging port to complete the recovery of the freeze-dried powder. The remaining air mixed with water vapor spirally descends between the separation cylinder 6 and the inner cylinder 7 to the lower end of the inner cylinder 7, and then enters the inner cylinder 7 to be finally sucked out from the vacuum air outlet on the upper end of the inner cylinder 7.

[0024] The separating mechanism is provided with a freeze-dried medicine powder recovery device, which comprises an inner cylinder brush 9, a separating cylinder brush 10, a brush support 11, an inner cylinder gear 12, a separating cylinder gear 13, a main gear 14, a gear shaft 15, a sub-gear 16, an inner ring gear 17 and a gear shaft circumferential driving mechanism. The inner cylinder brush 9 and the separating cylinder brush 10 are arranged in the vertical direction and are rotatably arranged on the brush support 11. The inner cylinder gear 12 is fixed on the upper end rotating shaft of the inner cylinder brush 9. The separating cylinder gear 13 is fixed on the upper end rotating shaft of the separating cylinder brush 10. The inner cylinder gear 12 and the separating cylinder gear 13 are respectively engaged with the main gear 14. The main gear 14 is fixed on the lower end of the gear shaft 15. The sub-gear 16 is fixed on the upper end of the gear shaft 15 and is engaged with the inner ring gear 17. The inner ring gear 17 is fixed on the top surface of the freezer body 1. The gear shaft 15 is connected with the gear shaft circumferential driving mechanism and is driven to rotate along the circumferential direction of the separating cylinder body 6 by the gear shaft circumferential driving mechanism.

[0025] The gear shaft circumferential driving mechanism comprises a driving rod 18, an outer ring gear 19, a sleeve 20, a driving gear 21 and a driving motor 22. The sleeve 20 is sleeved outside the air exhaust pipeline 5 and can rotate along the horizontal circumferential direction. The outer ring gear 19 is fixed on the upper end of the sleeve 20. The driving gear 21 is connected with the driving motor 22 and is driven to rotate by the driving motor 22. The driving gear 21 is engaged with the outer ring gear 19. The driving rod 18 is arranged in the radial direction of the outer ring gear 19 and one end of the driving rod 18 is fixedly connected with the outer ring gear 19. The upper end of the gear shaft 15 is rotatably arranged on the other end of the driving rod 18.

[0026] When the separating mechanism works, the driving motor 22 works to drive the driving gear 21 to rotate. The driving gear 21 drives the outer ring gear 19 and the sleeve 20 to rotate outside the air exhaust pipeline 5, thereby driving the driving rod 18 to rotate along the circumferential direction. The other end of the driving rod 18 drives the gear shaft 15 to rotate along the circumferential direction of the separating cylinder body 6, thereby driving the main gear 14 and the sub-gear 16 to rotate along the circumferential direction of the separating cylinder body 6 synchronously with the gear shaft 15. Because the sub-gear 16 is engaged with the inner ring gear 19, the sub-gear 16 forms relative displacement with the inner ring gear 19 when rotating circumferentially. The inner ring gear 19 drives the sub-gear 16 to rotate. The main gear 14 rotates synchronously with the sub-gear 16 and drives the inner cylinder gear 12 and the separating cylinder gear 13 to rotate, thereby driving the inner cylinder brush 9 and the separating cylinder brush 10 to rotate. The inner cylinder brush 9 and the separating cylinder brush 10 rotate along with the brush support 11 and the gear 15 to revolve along the circumferential direction, thereby realizing that the inner cylinder brush 9 and the separating cylinder brush 10 can brush the freeze-dried powder on the inner wall of the separating cylinder body 6 and the inner cylinder body 7 along the circumferential direction.

[0027] The number of inner cylinder rolling brushes 9 is two, and the number of separation cylinder rolling brushes 10 is also two, and the two inner cylinder rolling brushes 9 and the two separation cylinder rolling brushes 10 are distributed in a trapezoidal structure on the rolling brush support 11. Four rolling brushes are distributed in a trapezoidal structure, which can be respectively attached to the inner walls of the separation cylinder body 6 and the inner side cylinder body 7, and the trapezoidal structure can avoid the rotation of the rolling brush support 11 to form a limit, so that the main gear 14 can work normally.

[0028] As shown in Figure 5 The feeding mechanism 2 comprises a feeding hopper 23, a feeding pipeline 24, a spiral feeding roller 25 and a feeding driving motor 26. The feeding pipeline 24 is arranged in the horizontal direction, one end of the feeding pipeline 24 is connected with the feeding port on the side of the freezing box body 1, the spiral feeding roller 25 is arranged in the axial direction of the feeding pipeline 24 and is rotatably arranged in the feeding pipeline 24, one end of the spiral feeding roller 25 is connected with the feeding driving motor 26 and is driven to rotate by the feeding driving motor 26, and the other end of the feeding pipeline 24 is connected with the discharging port of the feeding hopper 23. The feeding valve 27 is arranged in the discharging port of the feeding hopper 23, and the upper end of the feeding hopper 23 is provided with an openable cover plate.

[0029] When the feeding hopper is used, the feeding valve 27 is opened, the medicament in the feeding hopper 23 enters the feeding pipeline 24, the feeding driving motor 26 drives the spiral feeding roller 25 to rotate, so that the medicament in the feeding pipeline 24 is extruded and conveyed into the freezing box body 1 to realize feeding.

[0030] As shown in Figure 6 The discharging mechanism 3 comprises a discharging main roller 28, a discharging auxiliary roller 29, a discharging conveying belt 30 and a discharging driving motor. The discharging main roller 28 and the discharging auxiliary roller 29 are rotatably arranged on both sides of the bottom of the freezing box body 1, the discharging conveying belt 30 is arranged on the discharging main roller 28 and the discharging auxiliary roller 29, and one end of the discharging main roller 28 is connected with the discharging driving motor and is driven to rotate by the discharging driving motor. The discharging valve 31 is arranged in the discharging port of the freezing box body 1. When the discharging end is used, the discharging driving motor is driven to rotate the discharging main roller 28, and at the same time, the discharging valve 31 is opened, and the freeze-dried medicament powder moves to the right along the discharging conveying belt 30 to the discharging port for discharging.

[0031] The application provides a pharmaceutical vacuum freeze-drying equipment, by increasing the separation mechanism of the inner and outer cylinder structure at the vacuum air outlet, the airflow sucked forms a cyclone between the inner and outer cylinder, under the action of centrifugal force, the solid powder collides on the inner wall of the separation cylinder and falls back into the freezing box, and the air mixed with water vapor is pumped out by the vacuum pump, which effectively avoids the freeze-dried powder from being pumped out by the vacuum pump, thereby reducing the waste of the medicament; the application also provides a freeze-dried powder recovery device, by the cooperation of the gear and the gear ring structure, the synchronous driving of the inner and outer rolling brushes is realized, the medicament powder on the cylinder wall is brushed off, and the recovery efficiency of the medicament powder is improved.

[0032] The above merely describes preferred embodiments of the present application, and is not intended to limit the present application in any form. Although the present application has been disclosed with preferred embodiments as above, it is not intended to limit the present application, and any person skilled in the art can make some changes or modifications to the above disclosed technical contents to obtain equivalent embodiments with equivalent changes, without departing from the technical solution of the present application. Any simple modification, equivalent replacement and improvement of the above embodiments, as long as it does not depart from the technical solution of the present application, and is within the spirit and principle of the present application, shall be within the protection scope of the present application.

Claims

1. A pharmaceutical vacuum freeze-drying apparatus, characterized by: It includes a freezing chamber, a feeding mechanism, a discharging mechanism, a vacuum pump, and a separation mechanism. The freezing chamber has a feeding port on one side, and the feeding mechanism is located on the feeding port. The freezing chamber has a discharging port on one side of the bottom, and the discharging mechanism is located at the bottom of the freezing chamber with its discharging end located above the discharging port. The freezing chamber has a vacuum extraction port on the top side, and one end of the extraction pipe is connected to the vacuum extraction port. The vacuum pump is located on the extraction pipe, and the separation mechanism is located on the vacuum extraction port.

2. The pharmaceutical vacuum freeze-drying apparatus according to claim 1, wherein: The separation mechanism includes a separation cylinder and an inner cylinder. The lower end of the separation cylinder is conical, and a discharge port is provided at the top of the conical structure at the lower end of the separation cylinder. The upper end of the separation cylinder is fixed to the top of the freezing box. An air inlet pipe is provided on the upper side of the separation cylinder, and the air inlet pipe is arranged tangentially along the separation cylinder. The inner cylinder is located inside the separation cylinder and is concentric with the separation cylinder. The upper end of the inner cylinder is fixed to the top of the freezing box, and the vacuum extraction port is located at the top of the inner cylinder.

3. The pharmaceutical vacuum freeze-drying apparatus according to claim 2, wherein: The separation mechanism includes a freeze-dried powder recovery device, which comprises an inner cylinder roller brush, a separation cylinder roller brush, a roller brush support, an inner cylinder gear, a separation cylinder gear, a main gear, a gear shaft, a secondary gear, an internal gear ring, and a gear shaft circumferential drive mechanism. The inner cylinder roller brush and the separation cylinder roller brush are arranged vertically and rotatably mounted on the roller brush support. The inner cylinder gear is fixed on the upper end of the inner cylinder roller brush shaft, and the separation cylinder gear is fixed on the upper end of the separation cylinder roller brush shaft. The inner cylinder gear and the separation cylinder gear mesh with the main gear, which is fixed at the lower end of the gear shaft. The secondary gear is fixed at the upper end of the gear shaft and meshes with the internal gear ring, which is fixed on the top surface of the freezer. The gear shaft is connected to the gear shaft circumferential drive mechanism and is driven by the gear shaft circumferential drive mechanism to rotate along the circumferential direction of the separation cylinder.

4. The pharmaceutical vacuum freeze-drying equipment according to claim 3, characterized in that: The gear shaft circumferential drive mechanism includes a drive rod, an external gear ring, a sleeve, a drive gear, and a drive motor. The sleeve is fitted on the outside of the air extraction pipe and can rotate along the horizontal circumferential direction. The external gear ring is fixed to the upper end of the sleeve. The drive gear is connected to the drive motor and driven to rotate by the drive motor. The drive gear meshes with the external gear ring. The drive rod is arranged radially along the external gear ring, and one end of the drive rod is fixedly connected to the external gear ring. The upper end of the gear shaft is rotatably arranged at the other end of the drive rod.

5. A pharmaceutical vacuum freeze-drying apparatus according to claim 4, characterized in that: The number of inner cylinder roller brushes is two, and the number of separation cylinder roller brushes is also two. The two inner cylinder roller brushes and the two separation cylinder roller brushes are distributed in a trapezoidal structure on the roller brush support.

6. The pharmaceutical vacuum freeze-drying equipment according to claim 1, characterized in that: The feeding mechanism includes a feeding hopper, a feeding pipe, a spiral feeding roller, and a feeding drive motor. The feeding pipe is arranged horizontally and one end of the feeding pipe is connected to the feeding port on the side of the freezer. The spiral feeding roller is arranged axially along the feeding pipe and is rotatably disposed inside the feeding pipe. One end of the spiral feeding roller is connected to the feeding drive motor and is driven to rotate by the feeding drive motor. The upper side of the other end of the feeding pipe is connected to the discharge port of the feeding hopper.

7. A pharmaceutical vacuum freeze-drying apparatus according to claim 6, characterized in that: The feed hopper is equipped with a feed valve at its discharge port and an openable cover at its upper end.

8. The pharmaceutical vacuum freeze-drying equipment according to claim 1, characterized in that: The discharge mechanism includes a main discharge roller, a secondary discharge roller, a discharge conveyor belt, and a discharge drive motor. The main discharge roller and the secondary discharge roller are rotatably mounted on both sides of the bottom of the freezing chamber. The discharge conveyor belt is mounted on the main discharge roller and the secondary discharge roller. One end of the main discharge roller is connected to the discharge drive motor and is driven to rotate by the discharge drive motor.

9. A pharmaceutical vacuum freeze-drying apparatus according to claim 1, characterized in that: The discharge port of the refrigeration unit is equipped with a discharge valve.

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