Oil-control soothing composition and application and cosmetic thereof

Abstract

The invention belongs to the field of daily chemicals, and discloses an oil-control soothing composition which comprises the following components in parts by weight: 0.5-5 parts of a yeast / zinc fermentation product; 0.5-5 parts by weight of a lactobacillus fermentation lysate; 0.5 to 5 parts by weight of dipeptide-15; 0.1-10 parts by weight of a flower / leaf / stem extract of hyperforin perforatum; and 0.5-5 parts by weight of an olive leaf extract. The composition adopts a yeast / zinc fermentation product, a lactobacillus fermentation lysate, dipeptide-15, a hyperforin perforatum flower / leaf / stem extract and an olive leaf extract to control oil from multiple angles, a good oil control effect is achieved, and meanwhile, the formula of the composition also has a relatively good soothing performance. Meanwhile, the invention further discloses application of the composition and cosmetics.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products, and more particularly to an oil-controlling and soothing composition, its application, and cosmetics. Background Technology

[0002] Under normal circumstances, sebum secreted by sebaceous glands maintains the skin's moisture and integrity while preserving a normal water-oil balance. However, with the fast pace of modern life, high stress levels, and insufficient sleep, abnormal sebum secretion, especially in oily skin, can lead to a series of skin problems: increased sebum secretion, closed comedones, seborrheic dermatitis, damaged skin barrier, and imbalance of skin flora.

[0003] Excessive sebum secretion from the skin glands causes shed keratinocytes to combine with the sebum and accumulate as keratin plugs in the hair follicles. The sebum is then broken down by bacteria into free fatty acids, which stimulate keratinocytes to produce pro-inflammatory factors, leading to an inflammatory response.

[0004] Abnormal sebum secretion is usually related to dihydrotestosterone (DHT) in the sebaceous glands. DHT is converted from testosterone by 5α-reductase. DHT can both promote the development of sebaceous glands and bind to receptors on the sebaceous glands. Excessive DHT levels cause excessive proliferation of sebaceous gland cells, resulting in excessive sebum secretion. Therefore, oil control is one way to improve skin problems.

[0005] Patent application CN116549373A, entitled "A composition for balancing skin sebum secretion, its preparation method and application," discloses a composition for balancing skin sebum secretion, its preparation method and application. The composition comprises the following components: Lactobacillus fermentation lysate, yeast / zinc fermentation product, nicotinamide, zinc PCA, medicinal fusiforme extract, *Salix fruticosa* extract, capryloyl glycine, Ceylon cinnamon bark extract, and sarcosine.

[0006] Its instructions clearly state that: Lactobacillus fermentation lysate can enhance stratum corneum metabolism, remove dead skin, remove cellular free radicals, inhibit lipid peroxidation, activate the body's repair performance, and inhibit cellular tyrosinase activity, resulting in excellent skin-smoothing and softening effects; Yeast / zinc fermentation product utilizes the ability of brewer's yeast to accumulate zinc during its growth and metabolism. Zinc exists in the form of chelates with highly active small molecules such as amino acids and polypeptides, reducing the skin irritation unique to inorganic zinc, while exerting multiple beneficial effects on the skin, such as anti-inflammatory, acne-reducing, oil-controlling, and dandruff-reducing properties.

[0007] Patent application CN118743664A, entitled "A Composition Containing Extracts of St. John's wort Flowers / Leaf / Stems and a Method for Preparing the Same," discloses the use of alcohol extraction and secondary fermentation techniques to extract St. John's wort flowers / leaf / stems, fully extracting the active substances from the flowers / leaf / stems. The extract is then combined with St. John's wort flower / leaf / stem extract, St. John's wort oil, wild mango kernel oil, Acacia acacia fruit extract, and sponge thorns to provide anti-inflammatory and oil-controlling effects while also moisturizing the skin.

[0008] The applicant believes that oil control is a multi-faceted, multi-target, and multi-channel skin care process, and to achieve better oil control results, a more in-depth study of the oil control mechanism is needed. Summary of the Invention

[0009] The purpose of this invention is to provide an oil-controlling and soothing composition. This composition uses yeast / zinc fermentation products, lactobacillus fermentation lysate products, dipeptide-15, extracts of St. John's wort flowers / leaves / stems, and olive leaf extract to control oil from multiple angles, achieving a good oil-controlling effect. At the same time, the formulation of this invention also has good soothing properties.

[0010] The present invention also discloses the application of the composition and cosmetics.

[0011] To achieve the above objectives, this application discloses:

[0012] An oil-controlling and soothing composition comprising the following components in parts by weight:

[0013] 0.5 to 5 parts by weight of yeast / zinc fermentation product;

[0014] 0.5-5 parts by weight of Lactobacillus fermentation lysate;

[0015] Dipeptide-15 0.5~5 parts by weight;

[0016] 0.1-10 parts by weight of extracts from the flowers, leaves, and stems of St. John's wort;

[0017] Olive leaf extract, 0.5-5 parts by weight.

[0018] The reason for selecting the above-mentioned active ingredients for combination in this invention is as follows:

[0019] 1. Yeast / Zinc Fermentation Products: The organic acids and small molecule carriers in yeast fermentation products promote the penetration of zinc ions into the sebaceous gland area and inhibit the expression of sebum secretion-related genes in SZ95 cells, thus controlling oil production at its source.

[0020] 2. Lactobacillus fermentation lysate: This is a type of microbial fermentation lysate. Lactobacillus fermentation lysate can help maintain the diversity and abundance of the skin's microbiome, reducing inflammatory sebum secretion caused by microbial imbalance; at the same time, it can promote the shedding of keratinocytes and prevent the formation of closed comedones due to excessive keratinization of hair follicles.

[0021] 3. Dipeptide-15: It can target chloride ion channels, promote the influx of Cl, regulate the intracellular ion balance, downregulate IL-1a to improve abnormal keratinization, shrink pores, and inhibit sebum secretion by sebaceous cells to achieve oil control.

[0022] 4. Extracts of St. John's wort flowers / leaves / stems: These extracts can control sebum production at the root level through multiple pathways. They inhibit sebum secretion by suppressing the expression and activity of the 5α-reductase gene and reducing dihydrotestosterone levels. They also inhibit sebum secretion by suppressing the pAkt / pErk1 / 2 signaling pathway and suppressing testosterone secretion in sebaceous cells. Furthermore, they regulate lipid synthesis and secretion through the SREBP-1 / PPAR-γ signaling pathway.

[0023] 5. Olive Leaf Extract: Obtained through fermentation of olive leaves with lactobacillus bacteria. This fermentation process can isolate various phytochemicals and phenolic compounds, such as oleuropein, flavonoids, anthocyanins, and tannins, which exhibit unique antioxidant properties and protect against immune damage. By scavenging free radicals generated during metabolism, it reduces lipid peroxidation and indirectly reduces increased sebum secretion caused by inflammatory factors.

[0024] The above-mentioned oil-controlling and soothing composition includes the following components in parts by weight:

[0025] 1-3 parts by weight of yeast / zinc fermentation product;

[0026] 1-3 parts by weight of Lactobacillus fermentation lysate;

[0027] Dipeptide-15 1~3 parts by weight;

[0028] 1-5 parts by weight of extract of St. John's wort flower / leaf / stem;

[0029] Olive leaf extract, 1-3 parts by weight.

[0030] Furthermore, the present invention also discloses the use of the oil-controlling and soothing composition described above in the preparation of cosmetics.

[0031] Finally, the present invention also discloses a cosmetic containing 1-5 wt% of the oil-controlling and soothing composition as described above.

[0032] Among the aforementioned cosmetics, the cosmetics include toners, lotions, serums, face creams, cleansers, and foundations.

[0033] This application has at least the following beneficial effects:

[0034] The composition of this invention achieves multi-angle, multi-channel, and multi-target oil control through different oil-control mechanisms. It can effectively improve the problem of excessive sebum secretion by skin glands and enlarged pores, and also soothe inflammation, thereby improving skin health. Attached Figure Description

[0035] Figure 1 These are bar charts and graphs showing the soothing effect of the sample from Example 1 on human skin.

[0036] Figure 2 This is a photograph of the soothing effect of the sample from Example 1 on human skin. Detailed Implementation

[0037] The present invention will now be clearly and completely described in conjunction with embodiments thereof. It should be noted that, unless otherwise specified in the embodiments, conditions are performed under conventional conditions or conditions recommended by the manufacturer. Reagents or instruments whose manufacturers are not specified are all commercially available products. Unless otherwise specified, all parts used in the embodiments of the present invention are parts by weight.

[0038] Source of raw materials

[0039] Yeast / Zinc Fermentation Products: Guangzhou Youran Biotechnology Co., Ltd., Yeast Essence Z20(N), 96.9%;

[0040] Lactobacillus fermentation lysate: Guangzhou Best Chemical Co., Ltd., Yue Shu Jing VHProbi® MixC, 90.3%;

[0041] Dipeptide-15: Guangzhou Best Chemical Co., Ltd., ReClear D15, 100%;

[0042] St. John's wort flower / leaf / stem extract: Shanghai Jiayu Biotechnology Co., Ltd., Bingjiling® St. John's wort flavonoids, 65.5-75.5%;

[0043] Olive Leaf Extract: Guangzhou Nuoran Biotechnology Co., Ltd., 20349PFCHI - ACB Olive LeafExtract PF, 100%.

[0044] Preparation of the composition

[0045] The composition of this invention is obtained by dissolving yeast / zinc fermentation product, lactobacillus fermentation lysate, dipeptide-15, extract of St. John's wort flower / leaf / stem and olive leaf extract in water, and adding p-hydroxyacetophenone, 1,2-hexanediol and butylene glycol as preservatives.

[0046] The formula can be found in Table 1;

[0047] Table 1 Formulation Table Unit: wt%

[0048] Yeast / Zinc Fermentation Products Lactobacillus fermentation lysate Dipeptide-15 St. John's wort flower / leaf / stem extract Olive leaf extract p-Hydroxyacetophenone 1,2-Hexanediol Butylene glycol Deionized water Example 1 0.5 5 0.5 5 0.5 0.5 0.5 2.0 Up to 100 Example 2 1 3 1 3 1 0.5 0.5 2.0 Up to 100 Example 3 2 2 2 3 2 0.5 0.5 2.0 Up to 100 Comparative Example 1 2 2 2 0 0 0.5 0.5 2.0 Up to 100 Comparative Example 2 2 2 2 3 0 0.5 0.5 2.0 Up to 100 Comparative Example 3 2 2 2 0 2 0.5 0.5 2.0 Up to 100

[0049] I. Performance Testing

[0050] 1.1 5α-reductase activity inhibition rate

[0051] 5α-Reductase is a key enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT), which in turn stimulates excessive sebum secretion from the sebaceous glands. The 5α-reductase inhibition rate test indirectly assesses the oil-controlling ability of a analyte by detecting its inhibitory effect on enzyme activity. During the experiment, 5α-reductase metabolizes testosterone into DHT, which then continues to react under the action of the enzyme. The product generated during this reaction exhibits a specific peak at a wavelength of 405 nm. By detecting the change in absorbance of this product at 405 nm, the amount of DHT produced is reflected, ultimately indicating the change in 5α-reductase activity, thus evaluating the inhibitory effect of the sample.

[0052] Inhibition rate = (Control group - Sample group) / (Control group - Blank group) * 100%

[0053] The control group consisted of a base material without the composition.

[0054] The blank group contains no composition or base material;

[0055] The sample groups are Examples 1-3 and Comparative Examples 1-3.

[0056] The inhibitory effects of Examples 1-3 and Comparative Examples 1-4 are shown in Table 2.

[0057] Table 2 Results of 5α-reductase activity inhibition rate test

[0058] sample absorbance Inhibition rate control group 0.995 - Blank group 0.040 - Example 1 0.685 32.46% Example 2 0.597 41.67% Example 3 0.232 79.89% Comparative Example 1 0.441 58.01% Comparative Example 2 0.289 73.93% Comparative Example 3 0.386 63.76%

[0059] 1.2 Human body oil control test

[0060] Methodological relevance

[0061] This test was conducted in accordance with standard T / ZHCA 002-2018, "Test Method for Oil Control Efficacy of Cosmetics".

[0062] Each sample group consisted of 10 healthy female / male volunteers aged 18-50, with oily skin and its sebum content.

[0063] ① The forehead was tested using the SM815 probe at days 0 and 14.

[0064] ② The changes in forehead oil were measured using an SM815 probe at 2H, 4H, and 8H.

[0065] Table 3 shows the oil content before and after use (long-lasting oil control); Table 4 shows the oil content before and after use (short-lasting oil control).

[0066] Table 3 Results of the Oil Control Experiment

[0067] sample <![CDATA[Before using the sample (average value) / μg / cm 2 > <![CDATA[Use sample for 14 days (average) / μg / cm 2 > Average change rate of oil Example 3 215.00 149.07 -30.66% Comparative Example 1 225.14 185.22 -17.73% Comparative Example 2 204.82 153.16 -25.22% Comparative Example 3 216.56 166.92 -22.92%

[0068] Table 4. Average Changes in Oil Content Before and After Use

[0069] As can be seen from the results in Tables 3 and 4, both the examples and the comparative examples showed oil-controlling effects, with Example 1 exhibiting the most significant short-term and long-term oil-controlling effects. Data from Example 3 and Comparative Example 3 demonstrate that the extract of St. John's wort flower / leaf / stem can enhance its oil-controlling efficacy. Data from Example 3 and Comparative Example 2 show that the olive leaf extract itself does not have an oil-controlling effect, suggesting that the olive leaf extract synergistically enhances the oil-controlling efficacy.

[0070] 1.2 Soothing and Anti-inflammatory Test

[0071] Example 1: Soothing effect on human skin

[0072] Relevance of the test method: Referring to the skin irritation test in the "Cosmetic Safety Technical Specifications", 10% lactic acid was used to stimulate facial skin. The EI value changes at 5 min, 15 min, and 30 min after product application were measured using an MX18 probe to evaluate the product's soothing effect. The test results are shown in Tables 5 and 6. Figure 1 and Figure 2 ;

[0073] Table 5. Average EI and rate of change for the blank group

[0074] base value Stimulation 5min 15min 30min Average EI value 266.89 312.22 354.33 343.11 335.67 rate of change / 16.99% 32.76% 28.56% 25.77%

[0075] Table 6. Average EI and rate of change for the sample groups

[0076] base value Stimulation 5min 15min 30min Average EI value 271.78 288.33 297.89 307.33 305.56 rate of change / 6.09% 9.61% 13.08% 12.43%

[0077] The EI value test results show that, compared with the blank group, the above data prove that the composition has a soothing effect.

[0078] Attached are photos taken by volunteer VISIA, showing before-and-after comparisons of product use (A in the photos represents the sample group, and B represents the blank group).

[0079] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description; thus, all changes falling within the meaning and scope of the claims are intended to be embraced within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. An oil-controlling and soothing composition, characterized in that, Includes the following components by weight: 0.5 to 5 parts by weight of yeast / zinc fermentation product; 0.5-5 parts by weight of Lactobacillus fermentation lysate; Dipeptide-15 0.5~5 parts by weight; 0.1-10 parts by weight of extracts from the flowers, leaves, and stems of St. John's wort; Olive leaf extract, 0.5-5 parts by weight.

2. The oil-controlling and soothing composition according to claim 1, characterized in that, Includes the following components by weight: 1-3 parts by weight of yeast / zinc fermentation product; 1-3 parts by weight of Lactobacillus fermentation lysate; Dipeptide-15 1~3 parts by weight; 1-5 parts by weight of extract of St. John's wort flower / leaf / stem; Olive leaf extract, 1-3 parts by weight.

3. Use of the oil-controlling and soothing composition as described in claim 1 or 2 in the preparation of cosmetics.

4. A cosmetic product, characterized in that, Contains 1 to 5 wt% of the oil-controlling and soothing composition as described in claim 1 or 2.

5. The cosmetic product according to claim 4, characterized in that, The cosmetics mentioned include toners, lotions, serums, face creams, cleansers, and foundations.

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