Ophthalmic medicine sterile delivery system capable of resisting pressure difference and preventing leakage

Abstract

The invention discloses an ophthalmology medicine pressure-difference-resistant leakage-proof sterile delivery system which comprises a drip nozzle, a valve body, a diaphragm valve and a sterilization filter element, a hollow spring column is arranged in an air collecting groove, the diaphragm valve is plugged on the air collecting groove, the drip nozzle is clamped on the valve body in a sealing mode, a distributor is arranged on the valve body in a sealing and sleeving mode, and the sterilization filter element is arranged on the valve body. A liquid dripping column with a liquid dripping hole is arranged on the dripping nozzle in an extending mode, a drainage column is arranged on the distributor in an extending mode, a plurality of drainage blocks are evenly distributed in the circumference of the drainage hole, the liquid dripping column abuts against the drainage blocks, a valve element coaxially aligned with a hollow spring column is arranged on the diaphragm valve, and the valve element abuts against the dripping nozzle to block the liquid dripping hole. The lower end of the valve element extends into the gas collecting groove, a pressure limiting deformation gap is reserved between the valve element and the hollow spring column, a reset spring is arranged between the valve element and the hollow spring column in a sleeved mode, the distributor is covered with a bottle cap, the bottle cap is provided with a conical plug, and the conical plug blocks the liquid dropping hole. The liquid medicine does not leak under the internal and external pressure difference environment.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical packaging, and more particularly to a sterile delivery system for ophthalmic drugs that is resistant to pressure differential leakage. Background Technology

[0002] In daily life, dropper bottles are needed for precise medication administration, the most common being eye dropper bottles. Currently, dropper bottles on the market have issues such as medication contamination from the air flowing back into the bottle after the medication is dispensed, and medication residue remaining on the dropper head.

[0003] To address this issue, a new type of sterile drip bottle with authorization number CN118415813B has emerged on the market. This bottle features an air-blocking design that allows for external disposal of residual liquid. After dripping, the conical valve core on the diaphragm valve, under the action of a return spring, seals the conical drip hole in the nozzle, preventing external air and residual medication from entering and contaminating the hole. Furthermore, when returning residual medication, the drainage channel is directly connected to the outside air, ensuring excellent return performance of the bottle. In practical use, it was found that the drip head of the sterile drip bottle, which was sealed in plains areas, would leak during high-altitude areas and air transport. Analysis revealed that after sealing in plains areas, the pressure inside the bottle was the same as the external air pressure due to the sealing effect of the drip head and the bottle body. However, when the sterile drip bottle entered high-altitude areas or was transported by air, the external air pressure was lower, creating a pressure difference between the bottle body and the external environment—the pressure inside the bottle was greater than the external air pressure. When the drip bottle was horizontal, the liquid medicine entered the inlet gap through the inlet hole. Under high pressure, the liquid medicine pushed against the diaphragm valve. Under this pushing force, the diaphragm valve moved away from the drip nozzle. At this point, the conical valve core in the diaphragm valve separated from the conical drip hole in the drip column, forming an outlet channel. The arc-shaped protrusion on the bottle cap could not provide a good seal, and the liquid medicine leaked out through the outlet channel. To address this issue, the drip head of a gas-barrier sterile drip bottle with external residual liquid treatment, authorized by announcement number CN118415813B, has been improved to prevent leakage due to pressure differential. Summary of the Invention

[0004] The purpose of this invention is to provide a pressure differential-resistant and leak-proof aseptic delivery system for ophthalmic drugs that can prevent leakage of the drug solution under internal and external pressure differential environments.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is: a sterile delivery system for ophthalmic drugs that is resistant to pressure differential and leak-proof, comprising: a nozzle, a valve body, a diaphragm valve, and a hydrophobic sterilizing filter element. The valve body is provided with a reflux groove, a vent hole, a gas collection groove, a liquid inlet hole, and several interconnected isolation grooves. A hollow spring column is provided in the gas collection groove. A sterilizing filter element is sealed on the valve body. The diaphragm valve is fixed to the valve body and sealed in the gas collection groove. A nozzle is sealed and clamped on the valve body, pressing against the diaphragm valve. A liquid inlet gap communicating with the liquid inlet hole is formed between the nozzle, the diaphragm valve, and the valve body. A distributor is sealed and fitted on the valve body. An annular gap communicating with the reflux groove is formed between the distributor and the nozzle. A conical platform and a drip column extend from the nozzle, with an inverted conical drip hole in the drip column. A conical platform and a drip column extend from the distributor. The dispenser is equipped with a drainage column and an inner conical hole. A drainage hole connected to the inner conical hole is located within the drainage column. Several drainage blocks are evenly distributed around the circumference of the drainage hole. A drainage groove connected to an annular gap is evenly distributed around the circumference of the inner wall of the dispenser. One end of the drainage groove transitions to the wall of the inner conical hole. The drip column extends into the drainage hole and abuts against the drainage blocks. The conical platform is located within the inner conical hole but does not fit against it. A valve core, coaxially aligned with a hollow spring column, is installed on the diaphragm valve. The upper end of the valve core abuts against the drip nozzle, sealing the drip hole. The lower end of the valve core extends into the gas collecting groove. A pressure-limiting deformation gap is left between the valve core and the hollow spring column. A return spring is fitted between the valve core and the hollow spring column. A bottle cap is placed on the dispenser, and a conical plug is installed on the bottle cap. The conical plug passes through the drainage hole and is inserted into the drip hole to seal it.

[0006] Furthermore, in the aforementioned sterile delivery system for ophthalmic drugs that is resistant to pressure differential and leak-proof, a sealing hole communicating with the drip orifice is provided on the inner side wall of the conical platform of the dropper. The lower end of the drip column extends into the sealing hole. A sealing ring protrudes from the side wall of the sealing hole. The valve core abuts against the lower end wall of the drip column, and the valve core and the sealing ring are sealed and fitted together.

[0007] Furthermore, in the aforementioned ophthalmic drug delivery system that is pressure differential resistant and leak-proof, the lower outer wall of the droplet column is an inclined wall, and a convex ring is provided extending upward at the upper end of the valve core, with the inner wall of the convex ring fitting against the outer wall of the lower end of the droplet column.

[0008] Furthermore, in the aforementioned ophthalmic drug delivery system that is resistant to pressure differential and leak-proof, a weight reduction hole is provided in the valve core.

[0009] Furthermore, in the aforementioned ophthalmic drug delivery system that is pressure differential resistant and leak-proof, a wedge-shaped hole adapted to a conical plug is provided on the large-diameter end of the dispensing orifice.

[0010] Furthermore, in the aforementioned sterile delivery system for ophthalmic drugs that is resistant to pressure differential and leak-proof, the top wall of the drainage block and the top wall of the drainage hole both slope downwards from the outside to the inside, and the two are connected by a straight line to achieve a smooth transition.

[0011] The advantages of this invention are as follows: When a sterile dropper bottle equipped with the ophthalmic drug delivery system described in this invention, capable of withstanding pressure differentials and preventing leakage, enters a low-pressure environment from a high-pressure environment, the conical plug on the bottle cap will remain sealed in the dropper orifice. Even if the liquid in the bottle pushes against the diaphragm valve under high pressure, preventing the valve core on the diaphragm valve from blocking the dropper orifice, the liquid cannot leak out after entering the dropper orifice, achieving a good sealing effect. Furthermore, a pressure-limiting deformation gap is maintained between the valve core of the diaphragm valve and the hollow spring column, ensuring that no matter how much force is applied... The pressure bottle can only dispense a fixed amount of liquid, ensuring that the liquid drips out as droplets rather than spraying out. A guide block in the drainage hole, resting against the drip column, diffuses small droplets into larger ones, reducing the impact on the eyes and minimizing user discomfort. A large gap between the nozzle and the dispenser improves the return flow of residual liquid and external air, as well as the airflow between the isolation tank and the external environment, allowing residual liquid in the isolation tank to evaporate more quickly. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of an ophthalmic drug delivery system that is resistant to pressure differential and leak-proof, as described in this invention.

[0013] Figure 2 yes Figure 1 A schematic diagram of the structure of the dropper.

[0014] Figure 3 yes Figure 1 A schematic diagram of the middle valve body.

[0015] Figure 4 yes Figure 1 A schematic diagram of the valve body from another direction.

[0016] Figure 5 Figure 4 A cross-sectional structural diagram.

[0017] Figure 6 yes Figure 1 A schematic diagram of the structure of a diaphragm valve.

[0018] Figure 7 yes Figure 1 A schematic diagram of the distributor.

[0019] Figure 8 yes Figure 1 A schematic diagram of the bottle cap structure. Detailed Implementation

[0020] The technical solution of the present invention will be further described below with reference to the accompanying drawings and preferred embodiments.

[0021] like Figures 1 to 8 As shown, the ophthalmic drug delivery system of the present invention, which is pressure differential resistant and leak-proof, includes: a dropper 1, a valve body 2, a diaphragm valve 3, and a hydrophobic sterilizing filter element 4. The valve body 2 is provided with a reflux groove 21, a vent 22, a gas collecting groove 23, a liquid inlet 24, and several interconnected isolation grooves 25. A hollow spring column 231 is provided in the gas collecting groove 23. The sterilizing filter element 4 is sealed on the valve body 2. Regarding the positional structure of the reflux groove 21, vent 22, gas collecting groove 23, liquid inlet 24, and several isolation grooves 25 on the valve body 2, and the connection structure between the sterilizing filter element 4 and the valve body 2, please refer to the gas-blocking sterile drip bottle with external residual liquid treatment, authorized publication number CN118415813B.

[0022] The diaphragm valve 3 is fixed on the valve body 2 and seals the gas collection groove 23. Regarding the connection structure between the diaphragm valve 3 and the valve body 2, please refer to the gas-blocking sterile drip bottle with external residual liquid treatment authorized announcement number: CN118415813B. Based on this, the present invention makes the following improvements to the diaphragm valve 3: a valve core 31 is provided on the diaphragm valve 3 and is coaxially aligned with the hollow spring column 231. A weight-reducing hole 311 is provided in the valve core 31 to reduce the weight of the diaphragm valve 3. A convex ring 312 is provided on the upper end of the valve core 31 and extends upward. The lower end of the valve core 31 extends into the gas collection groove 23. A return spring 5 is fitted between the valve core 31 and the hollow spring column 231. Under the pushing action of the return spring 5, a pressure-limiting deformation gap H is left between the valve core 31 and the hollow spring column 231.

[0023] A drip nozzle 1 is sealed and fitted onto the valve body 2, pressing against the diaphragm valve 3. An inlet gap 6, communicating with the inlet port 24, is formed between the drip nozzle 1, the diaphragm valve 3, and the valve body 2. A distributor 7 is sealed and fitted onto the valve body 2, forming an annular gap 71 between the distributor 7 and the drip nozzle 1, communicating with the return channel 21. Regarding the connection structure between the drip nozzle 1, the diaphragm valve 3, the valve body 2, and the distributor 7, please refer to the gas-blocking sterile drip bottle with external residual liquid treatment as described in authorization announcement number CN118415813B. Based on this, the present invention modifies the drip nozzle 1 and the distributor 7 as follows: A conical platform 11 and a drip column 12 extend from the nozzle 1. An inverted conical drip hole 121 is provided in the drip column 12. A wedge-shaped hole 122 is provided at the large-diameter end of the drip hole 121. A sealing hole 111 communicating with the drip hole 121 is provided on the inner wall of the conical platform 11 of the nozzle 1. The lower end of the drip column 12 extends into the sealing hole 111. The outer wall of the lower end of the drip column 12 is an inclined wall. A sealing ring 112 protrudes from the side wall of the sealing hole 111. The upper end of the valve core 31 on the diaphragm valve 3 abuts against the lower end wall of the drip column 12 under the pushing action of the return spring 5. The inner wall of the convex ring 312 is sealed to the outer wall of the lower end of the drip column 12. The cooperation between the convex ring 312 and the drip column 12 positions the diaphragm valve 3 and the valve core 31. The valve core 31 is sealed to the sealing ring 112. The sealing contact structure between the valve core 31 and the sealing ring 112 not only provides auxiliary sealing but also increases the friction between the valve core 31 and the nozzle 1, increasing the pushing force required for the diaphragm valve 3 to open. This makes the diaphragm valve 3 less likely to be pushed open in low- and medium-pressure environments. A drainage column 72 is extended from the distributor 7, and an inner conical hole is provided in the distributor 7. 73. A drainage hole 721 connected to the inner conical hole 73 is provided in the drainage column 72. Several drainage blocks 722 are evenly distributed around the circumference of the drainage hole 721. The top wall of the drainage block 722 and the top wall of the drainage hole 721 are both inclined downward from the outside to the inside. The two are connected by a straight line to achieve a smooth transition. A drainage groove 74 connected to the annular gap 71 is evenly distributed around the circumference of the inner side wall of the distributor 7. One end of the drainage groove 74 transitions to the hole wall of the inner conical hole 73. The drip column 12 extends into the drainage hole 721 and abuts against the drainage block 722. The conical platform 11 is located in the inner conical hole 73 and does not fit with the inner conical hole 73.

[0024] A bottle cap 8 is placed on the dispenser 7. Regarding the connection structure between the bottle cap 8 and the dispenser 7, please refer to the gas-blocking sterile drip bottle with external residual liquid treatment authorized announcement number: CN118415813B. Based on this invention, the bottle cap is modified as follows: a conical plug 81 is provided on the bottle cap 8, which is adapted to the wedge-shaped hole 122 on the drip hole 121. The conical plug 81 passes through the drainage hole 721 and is inserted into the wedge-shaped hole 122 to block the drip hole 121. A gap is left between the drainage column 72 and the bottle cap 8. When the conical plug 81 is inserted into the wedge-shaped hole 122, the sealing effect between the conical plug 81 and the wedge-shaped hole 122 is improved due to the limiting of the drip column 12 by the drainage block 722. Several hollow holes 82 are evenly distributed around the top wall of the bottle cap 8.

[0025] The ophthalmic drug delivery system described in this invention, capable of withstanding pressure differentials and preventing leakage, is installed on a bottle body. Injecting the drug solution into the bottle body yields a complete sterile dropper bottle. When the sterile dropper bottle is in a horizontal or inverted position, the drug solution in the bottle body enters the inlet gap 6 through the inlet hole 24. When the sterile dropper bottle moves from a high-pressure environment to a low-pressure environment, the drug solution in the bottle body, under high pressure, pushes against the diaphragm valve 3. The diaphragm valve 3 then moves the valve core 31 downwards, thereby opening the dropper hole 121, allowing the drug solution to enter. However, because the cone plug 81 is inserted into the wedge-shaped hole 122 to seal the dropper hole 121, the drug solution cannot leak out of the dropper hole 121, achieving a good sealing effect.

[0026] When in use, remove the bottle cap 8 and press the bottle to squeeze out the liquid. Because there is a pressure-limiting deformation gap H between the valve core 31 on the diaphragm valve 3 and the hollow spring column 231, no matter how much force the user applies to press the bottle, the deformation of the diaphragm valve 3 is limited, so only a fixed amount of liquid can be squeezed out. After the liquid pushes and deforms the diaphragm valve 3, the valve core 31 on the diaphragm valve 3 no longer blocks the drip hole 121, and the liquid flows out from the drip hole 121. Because the drip hole 121 is an inverted cone shape, the liquid flows from the small diameter to the large diameter in the drip hole 121, which slows down the flow rate. The liquid then gathers in the drip hole 121. Small droplets are formed in the wedge-shaped hole 122. As the liquid continues to flow out of the dripping hole 121, it pushes the small droplets to diffuse outward and come into contact with the drainage block 722. The drainage block 722 divides the liquid flowing out of the dripping hole 121 into multiple fine streams and further slows down the liquid. Due to the high surface tension of the liquid, the liquid converges at the drainage hole 721 under the guidance of the drainage block 722 and the inclined top wall of the drainage hole 721, forming a larger droplet than the small droplet. When the liquid converges into a large droplet, it further reduces the kinetic energy of the large droplet. When the large droplet falls into the eye, the contact area between the large droplet and the eye is large, which can reduce the impact on the eye and reduce the user's discomfort.

[0027] When the bottle body is no longer squeezed, the valve core 31, under the pushing action of the return spring 5, will block the drip hole 121. The negative pressure generated when the bottle body expands and resets will pass through the hollow spring column 231, the sterilization filter 4, the air collection groove 23, the return air hole 22, the return groove 21, and the annular gap 71, drawing the residual medicine in the drainage hole 721 along with the external air and drawing it back into the isolation groove 25. The residual medicine is isolated in the isolation groove 25, while the air, after being filtered by the sterilization filter 4, flows back into the bottle body. Because the drip column 12 in the dropper 1 abuts against the drainage block 722 of the drainage hole 721, the gap between the drip column 12 and the drainage hole 721 is increased, and the... The conical platform 11 in the dropper 1 does not fit into the inner conical hole 73 in the dispenser 7, leaving a large and continuous gap between the dropper 1 and the dispenser 7. Therefore, when the residual medicine is returned by negative pressure, the flow resistance of the external air is reduced, and the return efficiency of the residual medicine is improved. Moreover, the large gap improves the air flow between the isolation tank 25 and the external environment, and the residual medicine in the isolation tank 25 can evaporate faster. When the bottle cap 8 is closed on the dispenser 7, the isolation tank 25 continues to be connected to the external environment because of the hollow hole 82 on the bottle cap 8 and the conical plug 81 on the bottle cap 8 does not interfere with the drainage hole 721.

[0028] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the specific implementation of the present invention. Any modifications or equivalent substitutions that do not depart from the spirit and scope of the present invention should be covered within the scope of protection of the claims of the present invention.

Claims

1. A sterile delivery system for ophthalmic drugs that is resistant to pressure differential leaks, comprising: The application discloses a drip nozzle, a valve body, a diaphragm valve and a hydrophobic bacteria-removing filter element. The valve body is provided with a backflow groove, a backflow hole, a gas collecting groove, a liquid inlet hole and a plurality of isolation grooves connected with each other. The hollow spring column is arranged in the gas collecting groove. The bacteria-removing filter element is sealingly arranged on the valve body. The diaphragm valve is fixed on the valve body and blocks the gas collecting groove. The drip nozzle is sealingly arranged on the valve body and presses against the diaphragm valve. The liquid inlet gap connected with the liquid inlet hole is formed between the drip nozzle, the diaphragm valve and the valve body. The distributor is sealingly arranged on the valve body. The annular gap connected with the backflow groove is formed between the distributor and the drip nozzle. The conical table and the liquid dripping column are arranged on the drip nozzle. The inverted conical liquid dripping hole is arranged in the liquid dripping column. The drainage column is arranged on the distributor. The inner conical hole is arranged in the distributor. The drainage hole connected with the inner conical hole is arranged in the drainage column. The plurality of drainage blocks are circumferentially and uniformly distributed in the drainage hole. The drainage grooves connected with the annular gap are circumferentially and uniformly distributed on the inner side wall of the distributor. One end of the drainage groove is connected with the hole wall of the inner conical hole. The liquid dripping column extends into the drainage hole and abuts against the drainage blocks. The conical table is located in the inner conical hole and does not match with the inner conical hole. The valve core coaxially aligned with the hollow spring column is arranged on the diaphragm valve. The upper end of the valve core abuts against the drip nozzle and blocks the liquid dripping hole. The lower end of the valve core extends into the gas collecting groove. The pressure deformation gap is left between the valve core and the hollow spring column. The reset spring is sleeved between the valve core and the hollow spring column. The bottle cap is arranged on the distributor. The taper plug is arranged on the bottle cap and inserted into the liquid dripping hole to block the liquid dripping hole.

2. The sterile delivery system of claim 1, wherein: The blocking hole connected with the liquid dripping hole is arranged on the inner side wall of the conical table of the drip nozzle. The lower end of the liquid dripping column extends into the blocking hole. The sealing ring is protrudingly arranged on the side wall of the blocking hole. The valve core abuts against the lower end wall of the liquid dripping column. The valve core sealingly matches with the sealing ring.

3. The sterile delivery system of claim 2, wherein: The lower end outer side wall of the liquid dripping column is an inclined wall. The convex ring is upwardly arranged on the upper end of the valve core. The inner side wall of the convex ring matches with the outer side wall of the lower end of the liquid dripping column.

4. A sterile delivery system for ophthalmic drugs resistant to pressure difference and leakage according to any one of claims 1 to 3, characterized in that: The weight-reducing hole is arranged in the valve core.

5. The sterile delivery system of claim 4, wherein: The wedge-shaped hole matched with the taper plug is arranged on the large-diameter end of the liquid dripping hole.

6. The sterile delivery system of claim 4, wherein: The top wall of the drainage block and the top wall of the drainage hole are both inclined from outside to inside and downwardly. The two are connected through a straight line to achieve smooth transition.

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