Anti-expression-line composition containing cell signal factors and plant active ingredients and skin care product of anti-expression-line composition

Abstract

The invention relates to an expression line resisting composition containing cell signal factors and plant active ingredients and a skin care product of the expression line resisting composition. The expression line resisting composition is prepared from the following components in percentage by mass: 10 to 50 percent of cell signal factors, 10 to 50 percent of flos chrysanthemi extract and 10 to 50 percent of camellia seed oil. By adopting a composite strategy of metabolism regulation and neuromuscular regulation, nerve-muscular signal conduction is regulated, facial muscle tension is weakened, and dynamic formation of expression lines is reduced; the AMPK energy metabolism pathway is activated, and the cell activity is improved; rOS accumulation in cells is reduced, and the mitochondrial function is improved; strong fat-soluble anti-oxidation protection is provided, the action time is prolonged, barrier repair, moistening and anti-inflammation are facilitated, and therefore the more efficient expression line resisting effect is achieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-expression line composition containing cell signaling factors and plant active ingredients, and its skin care products. Background Technology

[0002] As people age into their 30s, they may increasingly choose anti-aging products for skincare. Among these, anti-expression lines are a primary concern, encompassing both dynamic and static wrinkles. The anti-aging effects achieved by addressing expression lines are particularly well-regarded.

[0003] Expression lines (dynamic wrinkles) are temporary creases formed by repeated contractions of facial muscles. They tend to solidify into static wrinkles with age and are an early sign of skin aging. Reducing or reversing expression lines can create a striking visual effect, and anti-expression line skincare products are playing an increasingly important role and providing greater effectiveness.

[0004] Currently, most anti-expression wrinkle products on the market achieve their effects by blocking nerve signals, repairing the dermis, and acting as antioxidants / anti-inflammatory agents. However, they may have some issues such as targeting only one specific point, having low bioavailability, or causing some irritation.

[0005] Patent CN115737472B discloses a composition containing recombinant collagen that can instantly reduce expression lines and its preparation method. By mass percentage, the raw materials include: 0.01%~0.2% recombinant collagen, 0.02%~2% trehalose, 3%~8% palmitoyl pentapeptide-4, 0.05%~2% palmitoyl tripeptide-1, 1%~5% acetyl hexapeptide-8, 0.005%~0.05% acetyl octapeptide-3, 0.001%~0.01% arginine, 0.01%~0.2% acetyl hexapeptide-1, 0.05%~2% panthenol, 0.01%~0.5% sodium hyaluronate, 0.05%~1% p-hydroxyacetophenone, 0.05%~1% 1,2-hexanediol, 0.5%~5% glycerol, 0.5%~6% butylene glycol, and the balance being water. The combination can synergistically regulate muscle cells and nerve cells, working together to soothe muscles and quickly reduce or eliminate dynamic facial wrinkles.

[0006] Patent CN114886792B discloses an anti-wrinkle composition comprising the following ingredients in parts by weight: 3-10 parts by weight of peach resin extract complex; 3-10 parts by weight of acetyl hexapeptide-8; 0.01-0.2 parts by weight of recombinant type III human collagen; and 0-12 parts by weight of β-alanylhydroxyprolyl diaminobutyrate benzylamine. It utilizes a highly branched peach resin extract complex to achieve physical skin tightening and smooth fine lines, thus achieving an immediate anti-wrinkle effect. Acetyl hexapeptide-8 is used to reduce the release of acetylcholine, thereby relaxing muscles and reducing the formation of expression lines. To reduce the number and depth of wrinkles, type III human collagen is used to promote fibroblast proliferation and accelerate collagen deposition and synthesis; β-alanylhydroxyprolyl diaminobutyrate benzylamine is used to promote the synthesis of type I collagen and protect elastin, further enhancing the long-term anti-wrinkle effect.

[0007] Currently, anti-aging products on the market primarily utilize three pathways to combat expression lines: neuromodulation, matrix repair, and oxidative defense. These pathways include nerve signal blockers, dermal repair agents, and antioxidants / anti-inflammatory agents. However, traditional methods often suffer from limitations: low bioavailability (>70% of active ingredients cannot penetrate the stratum corneum, such as peptides and polysaccharides); retinoic acid side effects (photosensitivity, requiring nighttime use), and irritation of the skin barrier (requiring a release formulation); and poor stability of vitamin C, which is prone to oxidation and discoloration. Furthermore, they target only a single point of action, making it difficult to simultaneously address dynamic wrinkles, static wrinkles, and skin barrier damage.

[0008] Existing active ingredients for anti-wrinkle expressions mainly suffer from issues of transdermal absorption, irritation, and stability. Although liposome encapsulation or some penetration enhancers can improve transdermal absorption or reduce irritation, these only improve absorption rate, stability, and reduce irritation to a certain extent. Furthermore, the content of active ingredients encapsulated in liposomes is generally very low, and even lower when added to the product. While stability and irritation are improved, there is still a risk of discoloration and irritation, and the problem cannot be completely solved.

[0009] Therefore, developing a more efficient, safe, and stable anti-wrinkle cosmetic has become an important research direction in anti-aging. Summary of the Invention

[0010] Current anti-expression line products mainly achieve their effects by blocking nerve signals, repairing the dermis, and acting as antioxidants / anti-inflammatory agents. However, they may have problems such as limited target, low bioavailability, or irritation. The purpose of this invention is to solve the above-mentioned technical problems and provide an anti-expression line composition containing cell signaling factors and plant active ingredients, as well as its skin care products.

[0011] The objective of this invention can be achieved through the following technical solutions: The present invention first provides an anti-wrinkle composition containing cell signaling factors and plant active ingredients, comprising the following components in mass content: 10-50% cell signaling factors, 10-50% chrysanthemum extract, and 10-50% camellia seed oil.

[0012] In one embodiment of the present invention, the cell signaling factor is a cell signaling factor derived from signaline™ sbiofunctional, and the chamomile extract is GATULINE IN-TENSE MB chamomile extract.

[0013] Unlike existing technologies, the components of the composition in this application are all oil-soluble, have excellent lipophilicity, and are well absorbed through the skin.

[0014] The present invention further provides a skin care product containing cell signaling factors and plant active ingredients, comprising the following components in the indicated mass percentages: 0.1-5% cell signaling factors, 0.1-5% chrysanthemum extract, 0.1-5% camellia seed oil, and the remainder being skin care excipients, wherein the skin care excipients are oil-soluble excipients.

[0015] In one embodiment of the present invention, the skin care product is an essential oil, essence, serum, lotion, or cream.

[0016] In one embodiment of the present invention, the skin care product is an essential oil, which comprises the following components in the indicated mass percentages: 0.1-5% cell signaling factor, 0.1-5% chamomile extract, 0.1-5% camellia seed oil, 0.1-2.0% fat-soluble antioxidant, 20-50% C9-12 alkyl, and the balance being squalane.

[0017] In one embodiment of the present invention, the essential oil further contains a fragrance, and the essential oil comprises the following components in the indicated mass percentages: 0.1-5% cell signaling factor, 0.1-5% chamomile extract, 0.1-5% camellia seed oil, 0.1-2.0% fat-soluble antioxidant, 20-50% C9-12 alkyl, 0.5-2.0% fragrance, with the balance being squalane.

[0018] In one embodiment of the present invention, the essential oil comprises the following components in the indicated mass percentages: 0.5-2% cell signaling factor, 0.3-1.2% chamomile extract, 1.0-4% camellia seed oil, 1.0% fat-soluble antioxidant, 30-40% C9-12 alkyl, and the balance being squalane.

[0019] In one embodiment of the present invention, the fat-soluble antioxidant is tocopherol (vitamin E).

[0020] The present invention further provides a method for preparing a skin care product containing cell signaling factors and plant active ingredients, wherein each component is added to a container or reactor and stirred at 300-400 rpm for 5-10 minutes to ensure uniform stirring; thus, a skin care product containing cell signaling factors and plant active ingredients is obtained.

[0021] The present invention further provides a method for preparing the anti-expression wrinkle essence oil, the method being: adding each component raw material into the main pot and stirring at 300-400 rpm for 5-10 minutes to ensure uniform stirring; thus obtaining the essence oil.

[0022] In one embodiment of the present invention, the method for preparing the anti-expression line essence oil is carried out under strict aseptic control during the entire production process.

[0023] In one embodiment of the present invention, the method for preparing the anti-expression line essence oil ensures that the mixing bowl is kept dry before preparation.

[0024] In one embodiment of the present invention, the method for preparing the anti-expression line essence oil involves filtering and sterilizing before filling, and quality control is performed by detecting bacterial content, toxins, immunogenicity, etc.

[0025] The present invention further provides a method for non-therapeutic anti-expression line treatment, wherein the anti-expression line composition or the skin care product is applied to facial skin.

[0026] In this application, the chamomile extract primarily soothes expression lines by regulating neuromuscular signal transduction and reducing facial muscle tension, thus decreasing the dynamic formation of expression lines. Cellular signaling factors mainly play a signal regulation role, activating the AMPK energy metabolism pathway, enhancing cell activity, reducing intracellular ROS accumulation, and improving mitochondrial function. Camellia seed oil acts as a lipid repair agent, providing potent lipid-soluble antioxidant protection. Maintaining the activity of cellular signaling factors and chamomile extract prolongs the duration of action and contributes to barrier repair, moisturizing, and anti-inflammatory effects.

[0027] Cellular signaling factors are a unique lipophilic compound primarily composed of 1,2-diglycerides from olive oil and fatty alcohols from jojoba wax. These factors activate enzyme signaling, enhance intracellular signal transduction efficiency, increase cellular energy, and promote epidermal and dermal regeneration. They inhibit stress- and age-related changes by altering signal transduction at different levels through interactions with signal receptors and various downstream molecules. The skin's ability to self-renew weakens with age, leading to increased skin fragility.

[0028] Slowed epidermal cell growth: The imbalance between cell proliferation and differentiation leads to thinning of the epidermis. Cell signaling factors increase extracellular signal-regulated kinases (ERK1 / 2) and promote epidermal differentiation. Loss of collagen connective tissue: The balance between extracellular matrix (ECM) synthesis and degradation regulated by various MAPK pathways is disrupted, tending towards ECM degradation. In aging skin, extracellular signal-regulated MAPK pathways (ERK), and related cell growth and ECM synthesis, are reduced by 50%, leading to wrinkles. Cell signaling factors increase ERK1 / 2 and promote ECM synthesis. Prevent age-related decline in signal transduction efficiency. Improve intracellular signal transduction efficiency and prevent stress-induced signal transduction changes, thereby preventing premature skin aging. Strengthening / regenerating body care products: Promote / improve dermal regeneration.

[0029] Cyperamide is the main active ingredient in chamomile extract, which can instantly reduce expression lines and tighten the dermal structure. Skin makes facial expressions through muscle contractions, forming temporary expression lines. With age, skin loosens, and repetitive muscle contractions deepen facial expression lines; even without muscle contraction, fine lines become permanent wrinkles. Botulinum toxin, a neurotoxin secreted by Clostridium botulinum, can block the release of nerve signals [acetylcholine], preventing muscle contraction. The SNARE complex forms, pulling acetylcholine vesicles to the cell membrane, leading to acetylcholine release—muscle contraction. Botulinum toxin destroys the SNARE complex, preventing acetylcholine vesicles from reaching the cell membrane, thus preventing acetylcholine release (an irreversible process)—leading to muscle paralysis and facial stiffness. Cyperamide, on the other hand, inhibits the transmission of electrical signals from nerve impulses, rapidly relaxing muscles. Cyperamide acts on nerve cells, inhibiting electrical signal transmission, quickly relaxing muscles, smoothing expression lines, and rapidly and completely preventing muscle contraction; it is reversible and safe. It also improves dermal structure by stimulating fibroblast activity, strengthening skin structure and tightening the skin.

[0030] The main components of camellia seed oil include linoleic acid, oleic acid, palmitic acid, stearic acid, and octadecanoic acid. In vitro tests have shown excellent results in its anti-irritant properties, collagen enhancement and protection, and antioxidant activity. Clinical data also indicate that camellia seed oil has good effects in skin soothing, enhancing skin barrier function, and reducing wrinkles.

[0031] This application breaks away from the traditional peptide / retinol pathway by employing a combined strategy of "metabolic regulation + neuromuscular modulation" to regulate neuromuscular signal transduction, reduce facial muscle tension, and decrease the dynamic formation of expression lines; activate the AMPK energy metabolism pathway to enhance cell activity; reduce intracellular ROS accumulation and improve mitochondrial function; provide potent lipid-soluble antioxidant protection, prolong the duration of action, and contribute to barrier repair and moisturizing anti-inflammatory effects, thereby achieving a more efficient anti-expression line effect.

[0032] Whether it's the immediate and long-lasting effects of the product on reducing expression lines or its gentleness, it has significant effects on protecting the skin, combating skin aging and oxidative stress, thus making the skin healthier.

[0033] The present invention also provides the application of the composition in skin care products, which can be combined with some base oils, fragrances, etc., according to different skin feel requirements, in order to achieve ideal skin feel and efficacy requirements.

[0034] Existing anti-aging, anti-wrinkle, and anti-expression line active ingredients are generally water-soluble and cannot be added to essence oil systems. The combination in this application is all oil-soluble and can be added at will, making up for the efficacy shortcomings of essence oil-based anti-aging products.

[0035] The anti-expression line composition in this application overcomes the transdermal bottleneck of traditional nerve signal blocking agents—biomimetic peptide active ingredients. Signal peptides generally have a molecular weight >500 Da (e.g., Argireline = 889 Da), low bioavailability, and more than 70% of the active ingredients cannot penetrate the stratum corneum. The compositions in this application are all oil-soluble, have good lipophilicity, and are well absorbed by the skin through transdermal absorption.

[0036] Traditional anti-wrinkle active ingredients containing dermal repair agents have certain side effects. Retinoic acid and its derivatives are photosensitizing and can irritate the skin barrier; vitamin C-based active ingredients are easily oxidized, have poor stability, and are prone to discoloration; coenzyme Q10 and resveratrol, among antioxidant / anti-inflammatory agents, also suffer from poor stability and are difficult to use. However, the solution presented in this application does not have these irritation and stability issues. Compared with existing technologies, this invention has the following beneficial effects: 1. The main function of chamomile extract is to soothe expression lines by regulating neuromuscular signal transmission, reducing facial muscle tension, and decreasing the dynamic formation of expression lines; 2. Cell signaling factors (signaline™ biofunctional) mainly regulate signaling: activate the AMPK energy metabolism pathway, enhance cell activity; reduce intracellular ROS accumulation, and improve mitochondrial function; 3. Camellia seed oil provides powerful lipid-soluble antioxidant protection through lipid repair; it stabilizes the activity of Signaline and chamomile, prolonging the duration of action; and it helps with barrier repair and moisturizing and anti-inflammatory effects.

[0037] 4. By adopting a combined strategy of "metabolic regulation + neuromuscular modulation", it regulates neuromuscular signal transmission, reduces facial muscle tension, and reduces the dynamic formation of expression lines; activates the AMPK energy metabolism pathway to enhance cell activity; reduces intracellular ROS accumulation and improves mitochondrial function; provides powerful lipid-soluble antioxidant protection, prolongs the duration of action, and helps with barrier repair and moisturizing and anti-inflammatory effects, thereby achieving a more efficient anti-expression line effect. Attached Figure Description

[0038] Figure 1 The illustrations show the improvement of under-eye wrinkles for two subjects (the top five images and the bottom five images represent two different subjects).

[0039] Figure 2 The illustrations show the improvement of crow's feet wrinkles in two subjects (the top five images and the bottom five images represent two different subjects). Detailed Implementation

[0040] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. These embodiments are based on the technical solution of the present invention and provide detailed implementation methods and specific operating procedures. However, the scope of protection of the present invention is not limited to the following embodiments.

[0041] All raw materials used in this invention are commercially available in the field, and the equipment used is conventional equipment in the field, such as... The signaline™ biofunctional cell signaling factor used in the following examples is sold by Suzhou Fuleite Biotechnology Co., Ltd.

[0042] The GATULINE IN-TENSE MB extract used was sold by Shanghai Puen Biochemical Technology Co., Ltd.

[0043] The Dongbaek Oil used was sold by Shanghai Ruimu Company.

[0044] In the examples below, C9-12 alkane is a synthetic alkane mixture commonly used in skincare products.

[0045] Example 1 Provide an essential oil and its preparation method: Table 1. Proportions of Components in Essential Oil Formula The essential oil is prepared by the following method: Before preparation, ensure the main pot is dry and free of moisture. Then, add each component ingredient to the main pot in sequence and stir at 300-400 rpm for 5-10 minutes to ensure even mixing. The resulting essential oil is filtered and sterilized before bottling, and quality control is performed by testing for bacterial content, toxins, immunogenicity, etc.

[0046] All of the above steps are performed under strict aseptic conditions.

[0047] Based on the above preparation method, specific Examples 1-3, Comparative Examples 1-6, and Blank Example 1 are provided. The only difference between Example 2 and Example 1 is the addition of each active ingredient, and the only difference between Example 3 and Example 1 is the reduction of each active ingredient.

[0048] The difference between Comparative Examples 1-3 and Example 1 is that only one key composition component is missing; the difference between Comparative Examples 4-6 and Example 1 is that two key composition components are missing; and the difference between Blank Example 1 and Example 1 is that all key composition components are missing.

[0049] Refer to Table 2 for specific proportions.

[0050] Table 2. Raw material composition ratios of Examples 1-3, Comparative Examples 1-6, and Blank Example 1. Characterization data and effect data of the products in the examples and comparative examples: 1. Security Testing (1) Test samples: essential oils of Examples 1-3, Comparative Examples 1-6 and Blank Example 1 as described in Table 2.

[0051] (2) Number of participants: 110, half male and half female, aged between 18 and 50 years old, all of whom met the criteria for participants.

[0052] (3) Testing Method: 110 participants meeting the subject criteria were randomly divided into 11 groups, corresponding to the essential oils obtained from Examples 1-3, Comparative Examples 1-6, and Blank Example 1 as described in Table 2. The blank group did not apply any sample. Each group consisted of 10 participants. Safety was tested by a third-party testing agency. Areas not exceeding 50 mm² were selected. 2 A suitable patch applicator with a depth of approximately 1 mm was used. Approximately 0.02-0.025 ml (g) of the test substance was added to the applicator using a closed patch test method. The applicator was applied to the flexor side of the subject's forearm. After 24 hours, the test substance was removed, and skin reactions were observed at 0.5 h, 24 h, and 48 h after removal. The results were recorded according to the skin reaction grading standards in the "Cosmetic Safety Technical Regulations 2015".

[0053] Table 3 Results of the patch experiment Note: Skin reaction grading standards: Grade 0: Negative reaction; Grade 1: Suspicious reaction; only slight erythema; Grade 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present; Grade 3: Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes: the reaction may extend beyond the tested area; Grade 4: Extremely strong reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex, reaction extending beyond the test area.

[0054] Test results: Table 3 shows no irritation, indicating a safe pass.

[0055] Efficacy evaluation test 1. Anti-expression line test (1) Test samples: essential oils of Examples 1-3, Comparative Examples 1-6 and Blank Example 1 as described in Table 2.

[0056] (2) Test subjects: 30 healthy women (30-60 years old) were randomly divided into 10 groups of 3 people each. Each group used the same formula product. Written informed consent was obtained. Before enrollment, a series of questions about medical history and health status were asked to the subjects according to the inclusion and exclusion criteria. At the same time, the skin of the test site was assessed for conformity and skin color was screened, and the results were recorded. (3) Environmental conditions: The visual assessment and instrument testing were conducted in an environment with a temperature of 21±1℃ and a relative humidity of 50±10% RH. The visual assessment was conducted under constant lighting conditions (fluorescent tubes or LED lights with a color temperature of 5500~6500K). Subjects were required to adapt to this environment for at least 30 minutes before assessment and testing could be conducted.

[0057] (4) Test method: Apply the sample twice a day, morning and evening, for 4 weeks. Apply an appropriate amount of the test sample to one cheek, and do not apply the test sample to the other cheek. Apply sunscreen to the entire face every morning.

[0058] Results were tested at the following three time periods: before sample use (D0), 1 week after sample use (W1), and 4 weeks after sample use (W4).

[0059] The test results can be calculated using the following formula: Rate of change = (Analysis value after product use - Analysis value before product use) ÷ Analysis value before product use × 100% (5) Specific test methods and instruments Instrumental analysis: Skin texture analyzer (such as VC20 plus): Applicable scenario: Fine line (micro-wrinkle) detection.

[0060] Procedure: Take three photos of the test area, take the average value of the parameters, and analyze the changes in the micro-texture of the epidermis.

[0061] 3D skin imaging systems (such as PRIMOS): Suitable for: Deep wrinkles (such as forehead wrinkles and crow's feet).

[0062] Procedure: A skin surface model is replicated using silicone, and then computer 3D reconstruction is performed using a CCD image sensor to accurately calculate the volume and area of ​​wrinkles.

[0063] Facial image analyzers (such as VISIA-CR): Applicable scenario: Analysis of wrinkle distribution across the entire face.

[0064] Procedure: Take facial photos from multiple angles, use fluorescent lighting to enhance wrinkle contrast, and quantify wrinkle length and density.

[0065] like Figure 1 The image shown illustrates a case study of improved under-eye wrinkles in a participant. Figure 2 The table shows a schematic diagram of the improvement of crow's feet wrinkles in the subjects. Table 4 shows the rate of change of static wrinkles, and Table 5 shows the rate of change of dynamic wrinkles.

[0066] Table 4 Static Texture Variation Rate Table 5 Dynamic Texture Change Rate As shown in Tables 4 and 5, the anti-expression line composition provided by this invention reduces the number and area of ​​static and dynamic wrinkles in the periorbital area to a certain extent, indicating that both static and dynamic wrinkles are improved after using this effective composition. The comparison shows that the components of the composition of this invention have a synergistic effect; when some components are missing, the efficacy of the composition is significantly reduced. The order of effectiveness is: Examples 1, 2, 3 > Comparative Examples 1, 2, 3 > Comparative Examples 4, 5, 6 > Blank Example 1, demonstrating that the synergistic effect of the three main active ingredients is the best, and it has a better anti-expression line effect than a combination of one or two components alone.

[0067] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A composition for treating expression lines containing cell signaling factors and plant active ingredients, characterized in that, The composition comprises the following components in the following mass content: cell signaling factor 10-50%, spilanthes extract 10-50%, and camellia seed oil 10-50%.

2. The anti-expression line composition containing a cell signal factor and a plant active ingredient according to claim 1, characterized in that, The cell signaling factor is signaline s biofunctional source cell signaling factor, and the spilanthes extract is GATULINE IN-TENSE MB spilanthes extract.

3. A skin care product comprising a cell signaling factor and a plant active ingredient, characterized in that, The composition comprises the following components in the following mass content: cell signaling factor 0.1-5%, spilanthes extract 0.1-5%, and camellia seed oil 0.1-5%, and the rest is a skin care auxiliary material which is an oil-soluble auxiliary material.

4. The skin care product containing cell signaling factor and plant active ingredient according to claim 3, characterized in that, The skin care product is an essence oil, an essence liquid, an essence lotion, an essence cream, or an essence.

5. The skin care product containing cell signaling factor and plant active ingredient according to claim 3, characterized in that, The skin care product is an essence oil, and the essence oil comprises the following components in the following mass content: cell signaling factor 0.1-5%, spilanthes extract 0.1-5%, camellia seed oil 0.1-5%, fat-soluble antioxidant 0.1-2.0%, C9-12 alkane 20-50%, and the rest is squalane.

6. The skin care product containing cell signaling factor and plant active ingredient according to claim 5, characterized in that, The essence oil further comprises a fragrance, and the essence oil comprises the following components in the following mass content: cell signaling factor 0.1-5%, spilanthes extract 0.1-5%, camellia seed oil 0.1-5%, fat-soluble antioxidant 0.1-2.0%, C9-12 alkane 20-50%, fragrance 0.5-2.0%, and the rest is squalane.

7. The skin care product containing cell signaling factor and plant active ingredient according to claim 5, characterized in that, The essence oil comprises the following components in the following mass content: cell signaling factor 0.5-2%, spilanthes extract 0.3-1.2%, camellia seed oil 1.0-4%, fat-soluble antioxidant 1.0%, C9-12 alkane 30-40%, and the rest is squalane.

8. The skin care product containing cell signaling factor and plant active ingredient according to claim 5, characterized in that, The fat-soluble antioxidant is tocopherol.

9. The method for preparing a skin care product containing a cell signal factor and a plant active ingredient according to claim 3, characterized in that, The components are added to a container or a reactor, stirred at 300-400 rpm for 5-10 minutes to ensure uniform stirring, and the skin care product containing the cell signaling factor and the plant active ingredient is obtained.

10. A method of anti-wrinkle for non-therapeutic purposes, characterized in that, The anti-expression wrinkle composition of claim 1 or the skin care product of claim 3 is applied to facial skin.

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