Membrane curtain for artificial lung as well as preparation method and application of membrane curtain

Abstract

The invention relates to the technical field of medical materials, and discloses a membrane curtain for an artificial lung as well as a preparation method and application of the membrane curtain. The membrane curtain for the artificial lung comprises hollow fiber membrane filaments and braided wires, the hollow fiber membrane filaments and the weaving lines are woven into a membrane curtain through a weaving method of a leno weave; the hollow fiber membrane yarns are distributed along the weft direction and are used as weft yarns; the weaving threads are distributed in the warp direction and serve as warp threads, and the warp threads are divided into ground warp threads and cross warp threads; the ground warps and the doup warps are woven through a forward twisting method; the weft-wise density of the membrane curtain is 10-20 hollow fiber membrane filaments per centimeter, and the warp-wise density of the membrane curtain is 5-15 ground warps per 10 centimeters and 5-15 cross warps per 10 centimeters. The hollow fiber membrane filaments and the weaving threads are woven into the membrane curtain through the weaving method of leno weave structure design and weaving on a rapier loom, the shape is stable, the manufacturing cost is low, the qualification rate of manufacturing of the membrane curtain for the artificial lung can be increased, and small sample preparation is rapidly achieved.

Description

Technical Field

[0001] This invention relates to the field of medical materials technology, specifically to an artificial lung membrane curtain, its preparation method, and its application. Background Technology

[0002] ECMO, short for Extracorporeal Membrane Oxygenation, also known as an artificial lung, is a system that provides continuous extracorporeal respiration and circulation to patients to sustain their lives in special circumstances (temporarily replacing lung function). Its core component is the membrane lung (artificial lung), which oxygenates the incoming blood and outputs oxygenated arterial blood. Currently, the most basic structure of a membrane lung consists of hollow fiber membranes (also called membrane filaments). Common membrane filaments are extremely thin tubes injection-molded from polymers such as poly(4-methyl-1-pentene) or polypropylene. Inside the membrane lung, many hollow fiber membrane filaments are fixed together. During use, oxygen flows through the tubes, while blood flows through the outside, thus achieving blood oxygen exchange and temporarily replacing the function of the lungs. A single membrane filament is obviously insufficient to achieve the required amount of blood oxygen exchange for a person; therefore, membrane filaments of a certain length are usually assembled into a large aggregate to complete gas exchange as quickly as possible.

[0003] US3422008A proposes a method of increasing the membrane contact area by winding spun cellulose acetate membrane filaments side-by-side to achieve osmotic exchange. US4620965A discloses a hollow fiber membrane lung assembly with high packing density and defoaming function, establishing the hollow fiber membrane artificial lung as the main alternative to porous materials. US10201648B2 discloses an artificial lung assembly that can pump blood in at low pressure for oxygenation, effectively reducing the difficulty of intubation and the risk of blood leakage under high operating pressure, and reducing patient trauma. It mentions that the membrane filaments are arranged parallel to each other in a knitted or woven structure. To prevent the membrane filaments from being affected by vibration during use, JP2021010466A demonstrates a knitted warp-knitted hollow fiber membrane assembly design, limiting the membrane filament diameter D to 0.15mm-0.75mm and the filament spacing to D / 2 to 2D mm. However, the aforementioned technical solutions do not explicitly mention the forming method of the knitted or woven structure.

[0004] However, to date, there are no mature ECMO products in China. Many research institutions are focusing on the research of the membrane fibers themselves and are in the stage of developing qualified membrane fibers. There are few reports on research on the fabrication of membrane curtains from these fibers. In fact, weaving membrane fibers into regular sheets is quite difficult, requiring specialized and precise weaving machines and demanding weaving processes. During the weaving process, the membrane fibers are very fine. To arrange them in a regular manner, they need to be bound with very precise force. Too much force will flatten or even break the membrane fibers, while too little force will not achieve the desired fixation. Therefore, the yield rate of membrane curtains is extremely low, resulting in very high production costs.

[0005] CN114272756A discloses a method of arranging membrane filaments to form a membrane curtain with different adhesive joints by means of intermittent adhesive bonding, and then bonding the two ends of adjacent membrane filaments together to form a membrane curtain assembly. The ultraviolet light curing adhesive used requires additional auxiliary heating and ultraviolet irradiation curing, which has a certain impact on the membrane filaments themselves, and the large adhesive joints will affect the working area of ​​the membrane filaments.

[0006] Therefore, given the huge demand for ECMO equipment in hospitals at all levels, it is both necessary and urgent to develop the technology for independently manufacturing membrane curtains. Summary of the Invention

[0007] The purpose of this invention is to solve the problems of the scarcity of existing precision knitting equipment, the high technical requirements for weaving membrane curtains, and the inability of the bonding method to meet the application requirements of ECMO membrane curtains.

[0008] To achieve the above objectives, the first aspect of the present invention provides a membrane curtain for an artificial lung, the membrane curtain comprising hollow fiber membrane filaments and braided threads;

[0009] The hollow fiber membrane filaments and braided threads are woven into a membrane curtain using a leno weave method.

[0010] The hollow fiber membrane filaments are distributed along the weft direction as weft threads; the braided threads are distributed along the warp direction as warp threads, and the warp threads are divided into ground warp and twisted warp.

[0011] The ground warp and twisting warp are woven using a forward twisting method;

[0012] The weft density of the membrane curtain is 10-20 hollow fiber membrane filaments / cm, and the warp density is 5-15 ground warp filaments / 10cm and 5-15 twisted warp filaments / 10cm.

[0013] The hollow fiber membrane filaments are made of polypropylene, with an outer diameter of 0.3-0.8 mm and a wall thickness of 0.03 mm-0.1 mm.

[0014] A second aspect of the present invention provides a method for preparing the membrane curtain for the artificial lung described in the first aspect, the method comprising the following steps:

[0015] 1) Input the designed fabric pattern into the loom program;

[0016] 2) Threading the heddles: Thread the heddles using either the right-hand or left-hand method;

[0017] 3) Passing through the reed: A set of ground-level and twisting reeds are passed through the same reed tooth;

[0018] 4) Weaving process: Through the processes of opening, weft insertion, beating, winding and warping, the membrane yarns and braiding threads are twisted together according to the designed leno weave pattern to form a membrane curtain;

[0019] The warp feeding is carried out using an equal pressure feeding method, and the warp tension is controlled between 10-60N.

[0020] A third aspect of the present invention provides an artificial lung membrane curtain prepared by the method described in the second aspect.

[0021] The fourth aspect of the present invention provides the application of the membrane curtain for artificial lungs described in the third aspect in an extracorporeal oxygenation membrane lung system.

[0022] This invention weaves hollow fiber membrane filaments and braided threads into a membrane curtain using a leno weave method. This method requires minimal equipment, has low manufacturing costs, improves the yield rate of artificial lung membrane curtains, and facilitates large-scale production. The artificial lung membrane curtain of this invention uses a small amount of membrane filaments, allowing for rapid preparation of small samples. During the preparation process, the artificial lung membrane curtain maintains a stable shape, facilitating subsequent casting into components. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of how the Earth Warp and the Twisting Warp are woven using the forward twisting method;

[0024] Figure 2 This is a diagram of the gauze tissue of the membrane curtain for the artificial lung in this invention;

[0025] Figure 3 This is a weaving diagram of the membrane curtain for artificial lungs according to the present invention;

[0026] Figure 4 This is a schematic diagram of the heddle threading method used in this invention;

[0027] Figure 5 This is a physical image of the artificial lung membrane curtain prepared according to Embodiment 1 of the present invention.

[0028] Figure 6 This is a schematic diagram of a membrane module used for gas flux testing.

[0029] Figure 7 This is a schematic diagram of a gas flux testing device.

[0030] Explanation of reference numerals in the attached figures

[0031] 1, 2, 3, 4 represent ground warp, I, II, III, IV represent twisted warp, 5 represents hollow fiber membrane filament, 6, 7, 8, 9 represent heddle filament, 6', 7', 8', 9' represent a row of pin holes corresponding to heddle filaments 6, 7, 8, 9; black squares ■ represent twisted warp above hollow fiber membrane filament, all of which are warp weaving points, and white squares □ represent ground warp below hollow fiber membrane filament. Detailed Implementation

[0032] The endpoints and any values ​​of the ranges disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed herein.

[0033] As mentioned above, a first aspect of the present invention provides a membrane curtain for an artificial lung, the membrane curtain comprising hollow fiber membrane filaments and braided threads;

[0034] The hollow fiber membrane filaments and braided threads are woven into a membrane curtain using a leno weave method.

[0035] The hollow fiber membrane filaments are distributed along the weft direction as weft threads; the braided threads are distributed along the warp direction as warp threads, and the warp threads are divided into ground warp and twisted warp.

[0036] The ground warp and twisting warp are woven using a forward twisting method;

[0037] The weft density of the membrane curtain is 10-20 hollow fiber membrane filaments / cm, and the warp density is 5-15 ground warp filaments / 10cm and 5-15 twisted warp filaments / 10cm.

[0038] The hollow fiber membrane filaments are made of polypropylene, with an outer diameter of 0.3-0.8 mm and a wall thickness of 0.03 mm-0.1 mm.

[0039] In a preferred embodiment, the weft density of the membrane curtain is 14-20 hollow fiber membrane filaments / cm, and the warp density is 6-15 ground warp filaments / 10cm and 6-15 twisted warp filaments / 10cm. The inventors have found that, in this preferred embodiment, the gas permeability of the membrane curtain is even better.

[0040] Preferably, the twisted warp is located above the hollow fiber membrane filament, and the ground warp is located below the hollow fiber membrane filament.

[0041] Preferably, a twisting assembly contains one twisting wire and one ground wire.

[0042] The "coordinated twisting method" described in this invention refers to the twisting direction of the twisting meridian and the ground meridian being consistent. For example: Figure 1 As shown, Earth Wire 1 and Twisted Wire I are twisted together, Earth Wire 2 and Twisted Wire II are twisted together, Earth Wire 3 and Twisted Wire III are twisted together, Earth Wire 4 and Twisted Wire IV are twisted together. The Twisted Wire is located above the hollow fiber membrane filament, and the Earth Wire is located below the hollow fiber membrane filament, and so on, to form a membrane curtain.

[0043] Preferably, the braided thread is a synthetic fiber filament bundle composed of 36-120 monofilaments, and the linear density of the synthetic fiber filament bundle is 40d-150d. The inventors found that under this preferred condition, the obtained artificial lung membrane curtain has a stable shape and a higher pass rate.

[0044] In a preferred embodiment, the chemical fiber filament is a low-elasticity filament.

[0045] Preferably, the material of the chemical fiber filament is selected from at least one of polypropylene, polyethylene, polyethylene terephthalate fiber, polyamide fiber, polyurethane fiber, and acetate fiber.

[0046] As previously described, a second aspect of the present invention provides a method for preparing the artificial lung membrane curtain described in the first aspect, the method comprising the following steps:

[0047] 1) Input the designed fabric pattern into the loom program;

[0048] 2) Threading the heddles: Thread the heddles using either the right-hand or left-hand method;

[0049] 3) Passing through the reed: A set of ground-level and twisting reeds are passed through the same reed tooth;

[0050] 4) Weaving process: Through the processes of opening, weft insertion, beating, winding and warping, the membrane yarns and braiding threads are twisted together according to the designed leno weave pattern to form a membrane curtain;

[0051] The warp feeding is carried out using an equal pressure feeding method, and the warp tension is controlled between 10-60N.

[0052] This invention is in Figure 2 An exemplary diagram of the gauze tissue of an artificial lung membrane curtain is provided.

[0053] This invention is in Figure 3 The document provides a preferred fabric loading diagram. Figure 3 In the diagram, 1, 2, 3, and 4 represent the ground warp, I, II, III, and IV represent the twist warp, and 5 represents the hollow fiber membrane filament. At the top of the weave diagram is the heddle threading diagram, where 6, 7, 8, and 9 each represent a row of heddles for the warp yarns to pass through. Above the weave diagram is the heddle threading diagram, and to the right is the heddle lifting diagram (also called the pattern board diagram). 6', 7', 8', and 9' each represent a row of pin holes, controlling the lifting of the corresponding heddle frame to form an opening. Furthermore, the row numbers of the pin holes represented by 6', 7', 8', and 9' correspond one-to-one with the row numbers of the heddles represented by 6, 7, 8, and 9.

[0054] In this invention, the left-hand threading method refers to the twill warp being threaded into the half-heald on the left side of the ground warp when viewed from the front of the machine; the right-hand threading method refers to one base heald being in front of the left side of the twill warp yarn, and another base heald being behind the right side of the twill warp yarn, with the twill warp threaded into the half-heald on the right side of the ground warp. Figure 4The example provided is a heddle-threading method using the right-hand threading technique. Figure 4 In the diagram, 1 represents the ground helix, I represents the twisted helix, 5 represents the hollow fiber membrane filament, 6 and 7 represent the base helix, 8 represents the post helix, 9 represents the ground helix, and 10 represents the semi-helix.

[0055] Preferably, during the reed threading process, the reed size is 10-120 teeth / 10cm.

[0056] Preferably, during the reed threading process, when the reed number is ≤90 reed teeth / 10cm, the empty reed method is adopted to keep the spacing between each group of warp threads 0.5-2cm.

[0057] Preferably, during the reed threading process, the reed width is greater than the width of the film curtain.

[0058] In this invention, a set of earth meridians and twisting meridians refers to a combination of one earth meridian and one twisting meridian (i.e., a twisting group). For example: earth meridian 1 and twisting meridian I, earth meridian 2 and twisting meridian II.

[0059] In a preferred embodiment, the weft insertion is performed using a long and short weft insertion method.

[0060] The long and short weft insertion methods described in this invention refer to the use of short and long weft insertion methods during the weft insertion process. For example: the first weft insertion uses a short weft insertion method, keeping the hollow fiber membrane filament 0.5-3 cm away from the weave opening. The heald frame changes position, forming a twist, and then the next opening is performed. Afterwards, a long weft insertion method is used to insert the hollow fiber membrane filament into the weave opening, reducing the backlash and rebound of the hollow fiber membrane filament.

[0061] Preferably, before the winding is performed, two weft insertions are performed first, followed by the winding.

[0062] Preferably, the take-up is performed using a step-by-step intermittent take-up method, with 0.22-0.85 mm taken up per weft.

[0063] In a preferred embodiment, the warp tension is controlled at 35-50N.

[0064] Preferably, in the weaving process, the shrinkage rate of the warp yarns is 5-15%. In this invention, a warp yarn shrinkage rate within the range of 5-15% allows for smooth weaving of the membrane curtain without flattening it. The warp yarn shrinkage rate is calculated using the following formula: (length of warp yarns fed during warp feeding - warp length of the woven membrane curtain) / length of warp yarns fed during warp feeding.

[0065] Preferably, in the weaving process, the shedding process refers to the movement of dividing the warp yarns into upper and lower pieces according to the interlacing pattern of the warp and weft yarns to form a shed.

[0066] In a preferred embodiment, double warp beams are used for weaving during the weaving process.

[0067] As previously described, a third aspect of the present invention provides an artificial lung membrane curtain prepared by the method described in the second aspect.

[0068] As previously stated, the fourth aspect of the present invention provides the application of the membrane curtain for artificial lungs described in the third aspect in an extracorporeal oxygenation membrane lung system.

[0069] The present invention will be described in detail below through embodiments. Unless otherwise specified, all raw materials used in the following embodiments are commercially available products.

[0070] Hollow fiber membrane fibers:

[0071] Hollow fiber membrane filament I: with an outer diameter of 0.45 mm and a wall thickness of 0.08 mm, it is made of PP powder of model MB1002 produced by Yanshan Petrochemical;

[0072] Hollow fiber membrane filament II: with an outer diameter of 0.58 mm and a wall thickness of 0.05 mm, it is made of PP powder of model MB1002 produced by Sinopec Yanshan Petrochemical;

[0073] Hollow fiber membrane filament III: outer diameter is 0.25mm, wall thickness is 0.02mm, material is PP, made of PP powder of model MB1002 produced by Sinopec Yanshan Petrochemical;

[0074] Hollow fiber membrane filament IV: with an outer diameter of 0.90 mm and a wall thickness of 0.15 mm, it is made of PP powder of model MB1002 produced by Sinopec Yanshan Petrochemical;

[0075] Braided yarn:

[0076] The poly(p-xylene) glycol low-elastic yarn has a linear density of 75d and is composed of 48 monofilaments. The specification is 75d / 48f. It was purchased from China Textile Academy Technology Development Co., Ltd.

[0077] The polyamide low-elasticity yarn has a linear density of 80d, is composed of 72 monofilaments, and has a specification of 80d / 72f. It was purchased from Changde Meihua Nylon Co., Ltd.

[0078] Example 1

[0079] Hollow fiber membrane filament I with an outer diameter of 0.45 mm and a wall thickness of 0.08 mm is used as the weft. Both the ground warp and the twill warp are made of 78d / 48f polyethylene glycol low-elastic yarn. The ground warp and the twill warp are woven by a straight twisting method. One ground warp and one twill warp are twisted together. The twill warp is located above the hollow fiber membrane filament, while the ground warp is located below the hollow fiber membrane filament. The positions of the healds are exchanged, and this cycle is repeated.

[0080] The weft density of the membrane curtain is set to 160 hollow fiber membrane filaments per 10 cm, and the warp density is set to 6 ground warp filaments per 10 cm and 6 twisted warp filaments per 10 cm. The number of groups of ground warp and twisted warp filaments per 10 cm is 6.

[0081] The preparation method includes the following steps:

[0082] 1) On the SGA598-SD semi-automatic sample loom, Figure 3 Input the fabric pattern onto the loom into the loom program;

[0083] 2) Heddle threading: according to Figure 4 The method shown is to pass through the heddle on the right, and the twisting meridian is to pass through the half-heddle on the right side of the earth meridian;

[0084] 3) Inserting the reed: A set of ground and twisting reeds must be inserted into the same reed tooth, with a gap in the middle, so that the interval between each set is kept at 1.6cm; the reed number is 75 reed teeth / 10cm;

[0085] 4) Weaving process: Through the processes of shedding, weft insertion, beating, winding, and warp feeding, the membrane fibers and braiding threads are continuously cyclical, so that they are twisted and woven according to the designed leno weave pattern to form the artificial lung membrane curtain (membrane curtain such as...). Figure 5 (as shown);

[0086] The process involves two weft-beating steps. The first weft-beating step uses a short weft-beating method to push the hollow fiber membrane filaments to a distance of 1.5cm from the weave opening. The heald frame is then repositioned to form a twist. The second weft-beating step is then performed. After the weft opening, the second weft-beating step uses a long weft-beating method to drive the hollow fiber membrane filaments into the weave opening.

[0087] The intermittent take-up method is adopted, with 0.62mm of take-up per weft; the constant tension warp feed is adopted, the warp tension is controlled at 45N, and the warp shrinkage rate is 8%.

[0088] Example 2

[0089] Hollow fiber membrane filament II with an outer diameter of 0.58 mm and a wall thickness of 0.05 mm is used as the weft direction. Both the ground warp and the twill warp are made of 80d / 72f polyamide low elastic yarn. The ground warp and the twill warp are twisted in the same direction, that is, one ground warp and one twill warp are twisted together. The twill warp is located above the hollow fiber membrane filament, while the ground warp is located below the hollow fiber membrane filament. The positions of the healds are exchanged, and this cycle is repeated.

[0090] The weft density of the membrane curtain is set to 140 hollow fiber membrane filaments per 10 cm, and the warp density is set to 7 ground warp filaments per 10 cm and 7 twisted warp filaments per 10 cm. Within each 10 cm, the number of groups of ground warp and twisted warp filaments is 7.

[0091] The preparation method includes the following steps:

[0092] 1) On the ASL2300-24D rapier loom, Figure 3 Input the fabric pattern onto the loom into the loom program;

[0093] 2) Heddle threading: according to Figure 4 The right-hand method is used for the crossing, and the twisting meridian is inserted into the half-combination on the right side of the earth meridian;

[0094] 3) Inserting the reed: A set of ground and twisting reeds are inserted into the same reed tooth, with a gap in the middle, so that the interval between different sets is maintained at 1.5cm; the reed number is 80 reed teeth / 10cm;

[0095] 4) Weaving process: Through the processes of opening, weft insertion, beating, winding and warping, the membrane filaments and braiding threads are continuously cyclical, so that they are twisted together according to the designed leno weave pattern to form a membrane curtain;

[0096] Among them, wefting is carried out in two ways. The first wefting is done with a short wefting method, which pushes the hollow fiber membrane filament to 1 cm away from the weave opening. The heald frame changes position to form a twist. Then, the second opening is carried out. After the opening, the second wefting is done with a long wefting method, which pushes the hollow fiber membrane filament into the weave opening.

[0097] The intermittent take-up method is adopted, with 0.54mm of take-up per weft; the constant tension warp feed is adopted, the warp tension is controlled at 35N, and the warp shrinkage rate is 3%.

[0098] Example 3

[0099] Hollow fiber membrane filament II with an outer diameter of 0.58 mm and a wall thickness of 0.05 mm is used as the weft. Both the ground warp and the twill warp are made of 80d / 72f polyamide low-elasticity yarn. The ground warp and the twill warp are woven by a straight twisting method. One ground warp and one twill warp are twisted together. The twill warp is located above the hollow fiber membrane filament, while the ground warp is located below the hollow fiber membrane filament. The positions of the healds are exchanged, and this cycle is repeated.

[0100] The weft density of the membrane curtain is set to 100 hollow fiber membrane filaments per 10 cm, and the warp density is set to 7 ground warp filaments per 10 cm and 7 twisted warp filaments per 10 cm. Within each 10 cm, the number of groups of ground warp and twisted warp is 7.

[0101] The preparation method includes the following steps:

[0102] 1) On the ASL2300-24D rapier loom, Figure 3 Input the fabric pattern onto the loom into the loom program;

[0103] 2) Heddle threading: according to Figure 4 The right-hand method is used for the crossing, and the twisting meridian is inserted into the half-tie on the right side of the earth meridian;

[0104] 3) Passing through the reed: A set of ground and twisting reeds must be passed through the same reed tooth, with the middle part of the reed left empty, so that the interval between different sets is kept at 1.5cm. The reed number is 75 reed teeth / 10cm.

[0105] 4) Weaving process: Through the processes of opening, weft insertion, beating, winding and warping, the membrane filaments and braiding threads are continuously cyclical, so that they are twisted together according to the designed leno weave pattern to form a membrane curtain;

[0106] The process involves two weft-beating steps. The first weft-beating step uses a short weft-beating method to push the hollow fiber membrane filaments to a distance of 1.5cm from the weave opening. The heald frame is then repositioned to form a twist. The second weft-beating step is then performed. After the weft opening, the second weft-beating step uses a long weft-beating method to drive the hollow fiber membrane filaments into the weave opening.

[0107] The weft is wound in a step-by-step intermittent manner, with 0.63mm wound per weft; constant tension warp feeding is used, with warp tension controlled at 35N; double warp beams are used for weaving, and the warp shrinkage rate is 8%.

[0108] Example 4

[0109] This embodiment uses a method similar to that of Embodiment 1, except that the weft density of the membrane curtain is set to 200 hollow fiber membrane filaments / 10 cm, the warp density is 15 ground warp / 10 cm, and 15 twisted warp / 10 cm, with 15 groups of ground warp and twisted warp within every 10 cm.

[0110] The remaining steps and parameter settings are the same as in Example 1.

[0111] Example 5

[0112] This embodiment uses a method similar to that of Embodiment 1, except that in the weaving process of step 4), equal tension warp feeding is used, and the warp tension is controlled at 60N;

[0113] The remaining steps and parameter settings are the same as in Example 1.

[0114] Comparative Example 1

[0115] This comparative example was carried out using a method similar to that of Example 1, except that hollow fiber membrane fiber I in Example 1 was replaced with hollow fiber membrane fiber III;

[0116] The remaining steps and parameter settings are the same as in Example 1.

[0117] Comparative Example 2

[0118] This comparative example was carried out using a method similar to that of Example 3, except that hollow fiber membrane fiber II in Example 3 was replaced with hollow fiber membrane fiber IV;

[0119] The remaining steps and parameter settings are the same as in Example 1.

[0120] Comparative Example 3

[0121] This comparative example was conducted using a method similar to that of Example 1. The difference was that the weft density of the membrane curtain was set to 80 hollow fiber membrane filaments / 10 cm, and the warp density was 4 ground warp filaments / 10 cm and 4 twisted warp filaments / 10 cm. The number of groups of ground warp and twisted warp filaments within each 10 cm was 4.

[0122] The remaining steps and parameter settings are the same as in Example 1.

[0123] Test case

[0124] The artificial lung membrane curtains prepared in the above examples were then subjected to performance testing.

[0125] 1. Membrane fiber spacing test

[0126] Cut a membrane curtain with a size of 20cm (weft) × 10cm (warp). Select 50 sites at equal intervals. Use a vernier caliper to measure the gap between adjacent membrane filaments at each site and record the number of sites where the gap between membrane filaments is greater than 0.4 times the outer diameter of the hollow fiber membrane filament.

[0127] 2. Nitrogen permeability test

[0128] Cut a membrane curtain to a size of 20cm (weft) × 2cm (warp), roll it up along the warp direction, and then fix the membrane curtain inside the self-made module along the weft direction. Seal both ends of the membrane curtain with hot melt adhesive (to prevent polyurethane adhesive from entering the membrane fiber cavity). Then cure the polyurethane adhesive. After the polyurethane adhesive has cured, cut it off at the solid red line to obtain a membrane module suitable for gas flux testing (e.g., ...). Figure 6 (As shown).

[0129] Place the membrane module in a gas flux testing device (e.g.) Figure 7 As shown, the gas flux testing device includes a nitrogen pipe, a nitrogen regulating valve, a rigid pipe, a pressure regulating valve, a quick-connect fitting, a membrane module, a pressure gauge, a pressure relief valve, a rubber hose, and a soap film flow meter. At room temperature, first fully open the pressure regulating valve, then slowly open the nitrogen regulating valve until the pressure gauge displays a pressure of 0.15 MPa. Close the pressure relief valve and slowly adjust the pressure regulating valve, setting the downstream pressure gauge pressures to 0.01 MPa, 0.05 MPa, and 0.09 MPa respectively. The nitrogen permeation flux through the membrane curtain is measured using a soap film flow meter. A small amount of soapy water is added to the rubber bulb at the bottom of the soap film flow meter, ensuring the liquid level is below the side inlet. During testing, the liquid level is raised above the side inlet, causing a soap film to appear in the glass tube. The time taken for the soap film to rise 30 mL is recorded. The nitrogen permeation rate of the membrane module is calculated using the following formula:

[0130]

[0131] In the formula, V represents the volume of soap bubbles flowing in the soap film flow meter, with units of m³. 3 P represents the test pressure during the flow process, in kPa; A represents the effective membrane area in the tested membrane curtain, in m². 2 t is the test time, in hours (h).

[0132] Two membrane curtains were randomly selected for testing in each embodiment. The test was performed three times at each test pressure (0.01MPa, 0.05MPa, 0.09MPa). The average value was calculated based on the test results under different test pressures. The specific results are shown in Table 1.

[0133] Table 1

[0134]

[0135] The results in the table above show that the membrane curtain provided by this invention has low equipment requirements, meets the requirements for membrane curtains used in artificial lungs, and has a gas permeability of less than 0.3 μm. 3 / m 2 ·h·kPa or above.

[0136] The preferred embodiments of the present invention have been described in detail above; however, the present invention is not limited thereto. Within the scope of the inventive concept, various simple modifications can be made to the technical solutions of the present invention, including combinations of various technical features in any other suitable manner. These simple modifications and combinations should also be considered as the content disclosed in the present invention and are all within the protection scope of the present invention.

Claims

1. A membrane curtain for an artificial lung, characterized in that The membrane curtain comprises hollow fiber membrane filaments and weaving threads; The hollow fiber membrane filaments and the weaving threads are woven into the membrane curtain by a weaving method of leno; The hollow fiber membrane filaments are distributed along the weft direction as weft threads; the weaving threads are distributed along the warp direction as warp threads, and the warp threads are divided into ground warp threads and twist warp threads; The ground warp threads and the twist warp threads are woven by a twist method; The weft density of the membrane curtain is 10-20 hollow fiber membrane filaments per centimeter, and the warp density is 5-15 ground warp threads per 10 centimeters and 5-15 twist warp threads per 10 centimeters; The hollow fiber membrane filaments are made of polypropylene, and the outer diameter of the hollow fiber membrane filaments is 0.3-0.8 mm and the wall thickness is 0.03-0.1 mm.

2. The membrane curtain according to claim 1, characterized in that, The weaving threads are chemical fiber filament bundles composed of 36-120 monofilaments, and the linear density of the chemical fiber filament bundles is 40 d-150 d.

3. The membrane curtain according to claim 1 or 2, characterized in that, The chemical fiber filaments are low-elasticity filaments. Preferably, the chemical fiber filaments are made of at least one of polypropylene, polyethylene, parylene glycol ester fiber, polyamide fiber, polyurethane fiber, and acetate fiber.

4. A method of making a membrane curtain for artificial lungs as defined in any one of claims 1-3, characterized by, The method comprises the following steps: 1) inputting a designed fabric loom pattern into a loom program; 2) harnessing: using right harnessing or left harnessing; 3) reeding: reeding a group of ground warp threads and twist warp threads into the same reed tooth; 4) weaving process: reeling the hollow fiber membrane filaments and the weaving threads into a membrane curtain according to a designed leno pattern through the steps of shedding, weft insertion, beating-up, take-up, and warp let-off; The warp let-off is performed by an equal-pressure warp let-off mode, and the warp tension is controlled at 10-60 N.

5. The method of claim 4, wherein, During the reeding process, the reed count is 10-120 reed teeth per 10 cm; Preferably, when the reed count is ≤90 reed teeth per 10 cm, the empty reed method is used to keep the spacing of the warp threads at 0.5-2 cm.

6. The method according to claim 4 or 5, characterized in that, The beating-up is performed by a long-short beating-up mode; Preferably, before the take-up, two beatings-up are performed, and then the take-up is performed.

7. The method according to any one of claims 4-6, characterized in that, The take-up is performed by a step-by-step intermittent take-up mode, and 0.22-0.85 mm is taken up per weft.

8. The method according to any one of claims 4-7, characterized in that, The warp tension is controlled at 35-50 N; Preferably, during the weaving process, the shrinkage of the warp is 5-15%.

9. A membrane curtain for artificial lung prepared by the method of claims 4-8.

10. Use of the membrane curtain for artificial lung of claim 9 in an extracorporeal oxygenation membrane lung system.

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