Full-automatic fluorescence immunoassay analyzer

Abstract

According to the full-automatic fluorescence immunoassay analyzer, a worker puts sample tubes with tube caps into a test tube rack, then the test tube rack containing a plurality of sample tubes is put into a conveying platform, the analyzer automatically conveys the test tube rack, then the sample tubes are rotated to a set angle by a direction adjusting mechanism, and then a sampling needle penetrates into the sample tubes to extract blood samples; the liquid taking needle also extracts a proper amount of reactant and sends the reactant into the mixing vessel, the mixing needle stirs the mixed liquid and then extracts a certain amount of reactant and drips the reactant into the reagent card, and the reagent card conveying mechanism conveys the reagent card into the reaction bin and sends the reagent card to the reagent card detector after the reaction is finished; the reagent card detector records a detection result and then sends out and collects used reagent cards; meanwhile, the cleaning mechanism is used for cleaning the sampling needle, the liquid taking needle and the mixing needle for next work; all sample tubes on the test tube rack are sent out along the conveying platform after being sampled. The full-automatic fluorescence immunoassay analyzer is high in automation degree, and the operation convenience, accuracy and working efficiency can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of full-automatic fluorescence immunoassay analyzer for blood detection. BACKGROUND

[0002] Many physical data of people can be analyzed by blood detection, and blood detection is also a commonly used medical detection method. Sample tubes are often used when blood is drawn, which include a cylindrical tube with an open top, the tube wall is marked with a scale, the tube cap is installed on the tube opening, and a flexible and deformable sealing flap is also provided in the middle of the tube cap. During blood drawing operation, medical staff need to insert the blood sampling needle on the blood drawing tube into the human body blood vessel, and then pierce the tail needle at the other end of the blood drawing tube into the sealing flap of the tube cap, so as to push the sealing flap away and allow the tail needle to be inserted into the inside of the sample tube. After blood drawing is completed, the tail needle is pulled out, the sealing flap rebounds and reseals the tube body, so as to avoid blood flow out or contact with the air outside to cause chemical reaction. Then, medical staff need to send the sample tube containing blood to the analyzer for blood analysis, and before being put into the analyzer, medical staff also need to shake the sample tube to make the blood sample more uniform, so as to prevent blood sedimentation and ensure the accuracy of detection.

[0003] The existing fluorescence immunoassay analyzer has low degree of automation, which not only needs manual shaking of the sample tube, but also needs the staff to pull out the tube cap, add an appropriate amount of reagent, and then put it into the instrument, and then take out the sample tube and get the detection result after waiting for enough time. The whole process needs the staff to have high participation, which leads to long time consumption and low work efficiency. SUMMARY

[0004] The purpose of the present application is to provide a fluorescence immunoassay analyzer with higher degree of full automation, to simplify the operation and improve work efficiency.

[0005] The full-automatic fluorescence immunoassay analyzer comprises a frame and a shell coated on the frame; one side of the frame is provided with a conveying platform for conveying a test tube rack and a test tube rack conveying mechanism; the shell is provided with a sampling port in the middle part opposite to the conveying platform; the frame is provided with a shaking mechanical arm for taking and placing a sample tube from the test tube rack and shaking, a sampling needle capable of penetrating the tube cap and extending into the sample tube; the frame is provided with a shaking driving mechanism and a sampling driving mechanism for driving the shaking mechanical arm and the sampling needle to move; the frame is further provided with a reagent box for containing a reagent, a mixing dish conveying mechanism for conveying a mixing dish, a liquid taking needle for taking the reagent from the reagent box and sending to the mixing dish, a liquid taking driving mechanism for driving the liquid taking needle to work, a mixing needle for taking the mixed liquid from the mixing dish, a mixing driving mechanism for driving the mixing needle to work, a reagent card conveying mechanism for conveying a reagent card, a reaction chamber for providing a constant temperature environment for the reagent card, a reaction conveying mechanism for taking and placing the reagent card from the reaction chamber, a reagent card detector for detecting the result of the reagent card and saving the detection result, and a cleaning mechanism for cleaning the sampling needle, the liquid taking needle and the mixing needle; the sampling driving mechanism and the liquid taking driving mechanism drive the sampling needle and the liquid taking needle to send the blood sample and the reagent to the mixing dish; the mixing driving mechanism drives the mixing needle to take the mixed liquid from the mixing dish and send to the reagent card; the reaction conveying mechanism sends the reagent card into the reaction chamber and sends the reagent card after the reaction to the reagent card detector.

[0006] The automatic fluorescence immunoassay analyzer is characterized in that: after medical staff members draw blood samples by using sample tubes, the sample tubes are placed on a test tube rack which can be used to place a plurality of sample tubes; after all blood drawing work is completed or the test tube rack is filled with sample tubes, the test tube rack is sent to a place where the automatic fluorescence immunoassay analyzer is located; then, the staff members place the test tube rack together with the sample tubes with tube caps on the test tube rack into an inlet at one end of a conveying platform, and the automatic fluorescence immunoassay analyzer automatically completes subsequent work. First, a test tube rack conveying mechanism sends the test tube rack to the middle part; then, a shaking manipulator lifts the sample tubes from the test tube rack and shakes the sample tubes under the drive of a shaking drive mechanism, and after a shaking setting time, the blood samples in the sample tubes are fully shaken; then, a sampling needle penetrates through the tube caps and extends into the sample tubes to draw the blood samples, and after the drawing is completed, the shaking manipulator places the sample tubes into the test tube rack again; or, the shaking manipulator places the sample tubes into the test tube rack, and then the sampling needle draws the blood samples; thereafter, the sampling needle moves to a mixing dish to discharge the blood samples into the mixing dish, and a liquid taking needle draws reaction reagents from a reagent box and sends the reaction reagents into the mixing dish; then, a mixing needle stirs the mixed liquid in the mixing dish under the drive of a mixing drive mechanism, and after the mixing is completed, the mixed liquid is drawn and dropped onto a reagent card; then, a reaction conveying mechanism sends the reagent card to a reaction bin, and after the reaction is completed, the reagent card is sent to a reagent card detector, the reagent card detector records detection results and then sends the reagent card out of the shell; meanwhile, a cleaning mechanism draws cleaning liquid and cleans the sampling needle, the liquid taking needle and the mixing needle, and the test tube rack conveying mechanism drives the test tube rack to move a set distance, so that another sample tube on the test tube rack is sent to the shaking manipulator; after the sampling needle, the liquid taking needle and the mixing needle are cleaned and another sample tube is moved to a position, the automatic fluorescence immunoassay analyzer repeats the above shaking, drawing, mixing and reaction steps, and after all the sample tubes on the test tube rack are completed, the test tube rack is sent from the middle part of the conveying platform to an outlet at the other end, and the staff members take away the test tube rack. The automatic fluorescence immunoassay analyzer has a high degree of automation, and the staff members only need to place the test tube rack on the conveying platform, and the automatic fluorescence immunoassay analyzer can complete all other operations; the staff members do not need to manually shake the sample tubes, remove the tube caps and place the sample tubes into the analyzer, and also do not need to manually add reaction reagents and place and take out the sample tubes one by one, so that the operation convenience and work efficiency are greatly improved; through automatic shaking and reaction reagent adding of the analyzer, the blood samples can be fully shaken and quantitative liquid taking is achieved, which is beneficial to improving detection precision and accuracy.

[0007] Preferably, the two ends of the conveying platform are respectively an inlet platform and an outlet platform on which two or more test tube racks can be placed side by side, and the inner side of the middle part of the conveying platform is a detection channel for conveying the test tube racks, and the test tube rack conveying mechanism drives the test tube racks to move along the inlet platform, the detection channel and the outlet platform; the sampling port on the shell is arranged opposite to the detection channel.

[0008] Preferably, the rack conveying mechanism comprises a feeding conveying mechanism, a discharging conveying mechanism and a detecting conveying mechanism for moving the rack along the feeding platform, the discharging platform and the detecting channel respectively.

[0009] Preferably, the rack is provided with a direction adjusting mechanism at the sampling port of the housing for adjusting the orientation of the sample tube, the direction adjusting mechanism comprising a rotatable direction adjusting wheel and a pressing wheel arranged on both sides of the entrance of the detecting channel respectively, the axes of the direction adjusting wheel and the pressing wheel being arranged vertically, and further comprising a direction adjusting motor one for driving the pressing wheel to push the sample tube to contact with the direction adjusting wheel, a direction adjusting motor two for driving the direction adjusting wheel to rotate and bring the sample tube to rotate, and a reader for detecting the label information on the sample tube.

[0010] Preferably, a queueing detecting rack is arranged between the feeding platform and the discharging platform, and further comprising a queueing detecting seat for placing the sample tube, the queueing detecting seat being movably arranged on the queueing detecting rack opposite to the sampling needle, and the moving direction of the queueing detecting seat being perpendicular to the detecting channel.

[0011] Preferably, the shaking manipulator comprises two shaking clamps arranged oppositely, one end of each of the two shaking clamps being rotatably connected to a shaking rotating shaft, a torsional spring being further sleeved on the shaking rotating shaft, one end of the torsional spring being fixedly arranged and the other end being lower than the outer side of the shaking clamps, and a recess for clamping the sample tube being arranged on the inner side of the other end of each of the two shaking clamps.

[0012] Preferably, the rack is provided with a plurality of mixing vessels which can be stacked, the bottom of the rack being open and both sides of the opening being provided with supporting plates for supporting the two sides of the bottom of the mixing vessel, and the bottom of the side of the rack being provided with an outlet for outputting the mixing vessel; the top of the mixing vessel being provided with a plurality of sample recesses for storing liquid sample at intervals, and the bottom of the mixing vessel being provided with a plurality of concave vessel pushing recesses at intervals; the rack being provided with a bottom plate, a conveying channel arranged on the bottom plate, a vessel pushing block arranged in the conveying channel and capable of extending into the vessel pushing recess, and a vessel driving device for moving the vessel pushing block along the conveying channel.

[0013] Preferably, the rack is provided with a plurality of reagent cards which can be stacked, the bottom of the rack being open and both sides of the opening being provided with supporting plates for supporting the two sides of the bottom of the reagent card, and the bottom of the side of the rack being provided with an outlet for outputting the reagent card; the reagent card conveying mechanism comprising a movable card feeding horizontal moving frame, the moving direction of the card feeding horizontal moving frame being parallel to the arrangement direction of the rack, the card feeding horizontal moving frame being provided with a card feeding vertical moving frame, and the card feeding vertical moving frame being provided with a reagent card pushing block capable of extending into the rack and pushing the reagent card to output.

[0014] Preferably, the reaction bin comprises an incubator with one side opening, and a plurality of reaction bin groups are arranged in the incubator, each reaction bin group is provided with a plurality of reaction chambers, the reaction chambers are arranged at the same side opening of the incubator, and a temperature controller is arranged in each reaction chamber.

[0015] Preferably, the cleaning mechanism comprises a cleaning pool filled with cleaning liquid, pipelines respectively connected with the sampling needle, the liquid taking needle and the mixing needle, a water pump connected with the pipelines and used for pumping the cleaning liquid from the cleaning pool to the sampling needle, the liquid taking needle or the mixing needle, and an air pump used for blowing air into the cleaning pool; the cleaning liquid is sprayed out of the sampling needle, the liquid taking needle or the mixing needle after entering the pipelines from the cleaning pool, and the sampling driving mechanism, the liquid taking driving mechanism and the mixing driving mechanism drive the sampling needle, the liquid taking needle and the mixing needle to extend into the cleaning pool respectively, and the water pump sprays air into the cleaning pool to make the cleaning liquid surge.

[0016] Through the above settings of the full-automatic fluorescence immunoassay analyzer, the materials such as the test tube rack, the mixing dish and the reagent card can be automatically transported, and the sample tube can be automatically adjusted in direction, so that the automation degree and the work efficiency are further improved. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a structural schematic diagram of a full-automatic fluorescence immunoassay analyzer.

[0018] Figure 2 is a structural schematic diagram of a full-automatic fluorescence immunoassay analyzer.

[0019] Figure 3 is a structural schematic diagram of a test tube rack transport mechanism.

[0020] Figure 4 、 5 is a structural schematic diagram of a feeding transport mechanism.

[0021] Figure 6 is a structural schematic diagram of a discharging transport mechanism.

[0022] Figure 7 is a structural schematic diagram of a test tube rack.

[0023] Figure 8 is a structural schematic diagram of a detection transport mechanism.

[0024] Figure 9 is a structural schematic diagram of a direction adjusting mechanism.

[0025] Figure 10 is a structural schematic diagram of a shaking driving mechanism.

[0026] Figure 11 is a structural schematic diagram of a shaking mechanical hand.

[0027] Figure 12 is a structural schematic diagram of a sample driving mechanism.

[0028] Figure 13 is a structural schematic diagram of a liquid driving mechanism.

[0029] Figure 14 is a structural schematic diagram of a dish box and a reagent box.

[0030] Figure 15 is a structural schematic diagram of a test mixing dish conveying mechanism.

[0031] Figure 16 is a structural schematic diagram of a reagent card conveying mechanism.

[0032] Figure 17 is a structural schematic diagram of a reaction chamber.

[0033] Figure 18 is a structural schematic diagram of a reaction conveying mechanism. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application.

[0035] It should be noted that if the embodiments of the present application involve directional indications (such as up, down, left, right, front, back, top, bottom, inner, outer, vertical, horizontal, longitudinal, counterclockwise, clockwise, circumferential, radial, axial, etc.), the directional indications are only used to explain the relative positional relationship, movement condition, etc. between components in a certain posture (as shown in the drawings), and if the certain posture changes, the directional indications also change accordingly.

[0036] If the embodiments of the present application involve descriptions of “first” or “second”, etc., the descriptions of “first” or “second”, etc. are only for description purposes, and cannot be understood as indicating or implying the relative importance of the indicated technical features or implicitly indicating the number of the indicated technical features. Therefore, the features with “first” or “second” can explicitly or implicitly include at least one of the features. In addition, the technical solutions of the various embodiments can be combined with each other, but it must be based on the fact that a person skilled in the art can realize it, and when the combination of technical solutions contradicts each other or cannot be realized, it should be considered that the combination of technical solutions does not exist and is not within the protection scope of the present application.

[0037] The application provides a full-automatic fluorescence immunoassay analyzer.

[0038] The full-automatic fluorescence immunoassay analyzer comprises a rack 1 and a shell 2 covering the rack; one side of the rack is provided with a horizontal conveying platform, two ends of the conveying platform are respectively an inlet platform 41 and an outlet platform 51 which can parallelly place two or more test tube racks 3, and the inner side of the middle part of the conveying platform is a detection channel 61 for conveying the test tube racks; the rack is provided with a test tube rack conveying mechanism which drives the test tube racks to move along the inlet platform, the detection channel and the outlet platform; The shell is provided with a sampling port at the position opposite to the detection channel; the rack at the sampling port is provided with a shaking mechanical arm 71 which takes and shakes sample tubes from the test tube racks, a sampling needle 81 which can pass through the tube cap and extend into the sample tube, a shaking driving mechanism 72 which drives the shaking mechanical arm to move, and a sampling driving mechanism 82 which drives the sampling needle to move; The rack is further provided with a reagent box 9 which contains reaction reagents, a mixing dish conveying mechanism 11 which conveys mixing dishes 10, a liquid taking needle 20 which takes reaction reagents from the reagent box and sends them to the mixing dishes, a liquid taking driving mechanism 21 which drives the liquid taking needle to work, a mixing needle 30 which takes mixed liquid from the mixing dishes, a mixing driving mechanism 31 which drives the mixing needle to work, a reagent card conveying mechanism 40 which conveys reagent cards, a reaction chamber 50 which provides a constant temperature environment for the reagent cards, a reaction conveying mechanism 60 which takes and places the reagent cards from and in the reaction chamber, a reagent card detector which detects the results of the reagent cards and saves the detection results, and a cleaning mechanism which cleans the sampling needle, the liquid taking needle and the mixing needle; The sampling driving mechanism and the liquid taking driving mechanism drive the sampling needle and the liquid taking needle to send blood samples and reaction reagents to the mixing dishes; the mixing driving mechanism drives the mixing needle to take mixed liquid from the mixing dishes and send it to the reagent cards; the reaction conveying mechanism sends the reagent cards into the reaction chamber and sends the reagent cards after the reaction to the reagent card detector.

[0039] As Figures 1-18As shown, after the medical staff draws blood samples with sample tubes, the sample tubes are placed on a test tube rack which can be used to place multiple sample tubes, and after all blood drawing work is completed or the test tube rack is full of sample tubes, the test tube rack is sent to the place where the automatic fluorescent immunoassay analyzer is located; then, the staff places the test tube rack together with the sample tubes with caps on the feeding platform, and the automatic fluorescent immunoassay analyzer automatically completes the subsequent work. First, the test tube rack conveying mechanism sends the test tube rack to the detection channel; then, the shaking mechanical hand lifts the sample tube from the test tube rack and shakes it under the drive of the shaking drive mechanism, and after the shaking is set for a certain time, the blood sample in the sample tube is fully shaken; then, the sampling needle penetrates through the cap and extends into the sample tube to draw the blood sample, and after the drawing is completed, the shaking mechanical hand re-places the sample tube into the test tube rack; or, after the shaking mechanical hand re-places the sample tube into the test tube rack, the sampling needle draws the blood sample again; thereafter, the sampling needle moves to the mixing dish to discharge the blood sample into the mixing dish, while the liquid taking needle draws the reaction agent from the cartridge and sends it to the mixing dish; then, the mixing needle stirs the mixed liquid in the mixing dish under the drive of the mixing drive mechanism, and after the mixing is completed, the mixed liquid is drawn and dropped onto the reagent card; then, the reaction conveying mechanism sends the reagent card to the reaction bin, and after the reaction is completed, it is sent to the reagent card detector, which records the detection result and then sends it out of the shell; at the same time, the cleaning mechanism draws cleaning liquid to clean the sampling needle, the liquid taking needle and the mixing needle, and the test tube rack conveying mechanism moves the test tube rack by a certain distance to make another sample tube on the test tube rack reach the shaking mechanical hand; after the sampling needle, the liquid taking needle and the mixing needle are cleaned, and another sample tube is moved into position, the automatic fluorescent immunoassay analyzer repeats the above shaking, drawing, mixing, reaction and other steps, and after all the sample tubes on the test tube rack are completed, the test tube rack is sent from the detection channel to the discharge platform, and the staff takes away the test tube rack.

[0040] The automatic fluorescent immunoassay analyzer, the feeding platform 41 and the discharge platform 51 can be placed side by side with two or more test tube racks 3, so that the staff can put in multiple test tube racks at the same time or take them out after the multiple test tube racks are sent out, which can reduce the work urgency of the staff, improve the operation convenience, reduce the risk of mistakes, and the inner sides of the feeding platform and the discharge platform are connected through the detection channel 61, and the outer sides are close to the staff, which can be more convenient to take the test tube rack. As shown, Figure 3 The test tube rack conveying mechanism includes feeding conveying mechanism 42, discharge conveying mechanism 52 and detection conveying mechanism 62 which drive the test tube rack 3 to move along the feeding platform 41, the discharge platform 51 and the detection channel 61 respectively, so as to more accurately and quickly drive the test tube rack to move along different positions of the conveying platform; wherein, as shown, Figure 4 , 5As shown, the feeding platform 41 is provided with a feeding channel 43 connecting the upper and lower sides along the conveying direction; the feeding conveying mechanism 42 comprises a feeding guide rail 44 installed below the feeding platform and parallel to the feeding channel, a feeding sliding block 45 movably installed on the feeding guide rail, and a feeding motor assembly 46 driving the feeding sliding block to move, the feeding sliding block is connected with a feeding push rod 47, a feeding push plate 48 is hingedly connected to the feeding push rod through a torsion spring, one end of the feeding push plate is rotatably extended out of or shrunk below the feeding channel, the torsion spring applies a force to the feeding push plate to make it extended out of the feeding channel, the other end of the feeding push plate is provided with a limiting part abutting against the feeding push rod and making the feeding push plate continuously extended out of the feeding channel, which makes the feeding push plate fixedly push the test tube rack on the feeding platform to the inner side, i.e. the outlet end of the feeding platform, at this time the feeding motor assembly drives the feeding push plate to move outward through the feeding sliding block and the feeding push rod, when the feeding push plate contacts with other test tube racks, the feeding push plate is pressed and shrunk below the feeding channel until it moves to the outermost side and is extended out of the feeding channel again under the action of the torsion spring, and then exerts a pushing action on the remaining test tube racks; the feeding conveying mechanism is fast and accurate, which is beneficial to improve the working stability and efficiency; the feeding motor assembly 46 can be a motor and a screw nut pair, or a motor and a conveying belt.

[0041] As shown in Figure 4 、 6 , similarly, the discharging platform 51 is provided with a discharging channel 53 connecting the upper and lower sides along the conveying direction; the discharging conveying mechanism 52 comprises a discharging guide rail 54 installed below the discharging platform and parallel to the discharging channel, a discharging sliding block 55 movably installed on the discharging guide rail, and a discharging motor assembly 56 driving the discharging sliding block to move, the discharging sliding block is connected with a discharging push rod 57, the push rod moves along the discharging channel with the discharging motor assembly working, so as to push the test tube rack outward to the outside of the discharging platform; the discharging conveying mechanism can be better hidden in the machine, compared with the feeding conveying mechanism, the feeding push plate hingedly connected to the discharging push rod is no longer installed, but the discharging push rod is directly used to push the test tube rack, which has better working stability and service life. Similarly, the discharging motor assembly can be a motor and a conveying belt.

[0042] As shown in Figure 4 、 7As shown in Figure 8, the bottom surface of the test tube rack 3 is provided with several tube rack pushing recesses at intervals. The detection channel 61 has a detection through groove 63 connecting the upper and lower sides along the conveying direction. The detection conveying mechanism 62 includes a detection guide rail 64 installed below the detection channel and parallel to the detection through groove, a detection slider 65 movably installed on the detection guide rail, and a detection motor assembly 66 driving the detection slider. The detection slider is connected to a detection push rod 67, and a detection push plate 68 is hinged to the detection push rod. The detection push plate is inclined, with one end passing through the detection through groove and extending into the tube rack pushing recess. A spring 69 is also installed between the end of the detection push plate and the detection push rod, using the spring to move the detection push plate... The end-effector inserts into the tube rack, pushing the recessed platform. Driven by the detection motor assembly, it moves towards the discharge platform, propelling the test tube rack a specific distance. This allows the sample tubes on the rack to move one by one to the swaying robotic arm. After completing the required movement distance for one sample tube, the detection motor assembly drives the detection push plate towards the feeding platform. The push plate inserts into the adjacent tube rack, pushing the recessed platform and continuing to push the test tube rack until all sample tubes on the rack have been sampled. Finally, the test tube rack is pushed to the discharge platform. This detection conveying mechanism works in conjunction with the test tube rack to stably move the sample tubes one by one to the sampling station, ensuring operational stability and accuracy. Similarly, the detection motor assembly can also consist of a motor and a conveyor belt.

[0043] like Figure 2 , 9 As shown, the frame 1 is also equipped with an adjustment mechanism 80 at the sampling port of the outer casing 2 to adjust the orientation of the sample tube. The adjustment mechanism includes a rotatable adjustment wheel 801 and a pressure wheel 802 respectively set on both sides of the inlet end of the detection channel 61. The axes of the adjustment wheel and the pressure wheel are arranged vertically. There is also an adjustment motor 803 that drives the pressure wheel to push the sample tube into contact with the adjustment wheel, an adjustment motor 804 that drives the adjustment wheel to rotate and drives the sample tube to rotate, and a reader that detects the label information on the sample tube. This makes the label on the sample tube face the reader so as to obtain the recorded information on the sample tube and accurately correspond to the source of the blood sample, without the need for the staff to put the sample tube into the test tube rack in a specific orientation, thereby further improving the degree of automation and ease of operation. Two clamping rollers 802 are arranged side by side, each acting on the sample tube. They cooperate with the directional roller to form a three-point positioning, thereby improving the accuracy of sample tube orientation. There is also a steering sensor 805 for detecting the working position of the clamping rollers 802. At the same time, a movable push rod 806 is installed between the two clamping rollers. One end of the push rod facing the sample tube is rounded, and the other end is connected to the directional frame with a spring. The spring applies a force to the push rod to move it toward the sample tube. The push rod further improves the working stability of pushing the sample tube, and its rounded end does not obstruct the rotation of the sample tube.

[0044] like Figure 3As shown, a queue-jumping detection rack 91 is installed between the feeding platform 41 and the discharging platform 42, and a queue-jumping detection seat 92 for placing sample tubes is also provided. The queue-jumping detection seat is movably installed on the queue-jumping detection rack opposite to the sampling needle 81, and the moving direction of the queue-jumping detection seat is perpendicular to the detection channel 63, so that temporary or urgently needed sample tubes can be queued for detection through the queue-jumping detection rack and the queue-jumping detection seat to meet specific needs.

[0045] like Figure 10 As shown, the shaking drive mechanism 72 includes a shaking longitudinal frame 73 that can move back and forth, a shaking vertical frame 74 mounted on the shaking longitudinal frame and capable of moving up and down, and a shaking bracket 75 mounted on the shaking vertical frame. The shaking bracket is equipped with a shaking driver 76 that can rotate in both directions, and the shaking manipulator 71 is connected to the shaking driver. Before operation, the shaking manipulator is located behind the sampling port of the outer casing. After the test tube rack is moved into place, the shaking longitudinal frame moves the shaking manipulator toward the sample tube and clamps the sample tube; then the shaking vertical frame moves the shaking manipulator upward, causing the sample tube to leave the test tube rack. Then, under the drive of the shaking driver, it rotates back and forth, thereby producing a shaking effect to fully shake the blood sample in the sample tube; after shaking and sampling, the shaking vertical frame and the shaking longitudinal frame move in opposite directions to put the sample tube back into the test tube rack, or to lower the sample tube for sampling needle to take a sample. The aforementioned swaying longitudinal and swaying vertical frames can be respectively mounted on guide rails and connected to a driver, moving along the guide rails under the drive of the driver; this swaying drive mechanism operates accurately and can effectively improve working stability. Figure 11 As shown, the shaking manipulator 71 includes two shaking clamps 77 arranged opposite each other. One end of each shaking clamp is rotatably connected to a shaking shaft 78. A torsion spring 79 is also sleeved on the shaking shaft. One end of the torsion spring is fixedly set, and the other end is lower than the outer side of the shaking clamp. It applies a force to the two shaking clamps to clamp them together, thereby clamping the sample tube. At the same time, the inner side of the other end of the two shaking clamps is provided with a groove for clamping the sample tube, so that when the shaking clamp moves toward the sample tube, it can automatically open along both sides of the sample tube and stably clamp the sample tube.

[0046] like Figure 12 As shown, the sampling drive mechanism 82 includes a sampling longitudinal transfer frame 83 that can move back and forth, and a sampling vertical transfer frame 84 mounted on the sampling longitudinal transfer frame and capable of moving up and down. The sampling needle 81 is mounted on the sampling vertical transfer frame. Similarly, the mixing drive mechanism 31 includes a mixing longitudinal transfer frame 32 that can move back and forth, and a mixing vertical transfer frame 33 mounted on the mixing longitudinal transfer frame and capable of moving up and down. The mixing needle 30 is mounted on the mixing vertical transfer frame. In addition, the sampling longitudinal transfer frame 83 and the mixing longitudinal transfer frame 32 can be mounted on the same mounting plate within the frame 1 to simplify the structure and reduce the size of the equipment. Furthermore, as... Figure 13As shown, the liquid taking driving mechanism 21 includes a longitudinally movable liquid taking longitudinal carriage 22, and a vertically movable liquid taking vertical carriage 23 installed on the liquid taking longitudinal carriage, and the liquid taking needle 20 is installed on the liquid taking vertical carriage.

[0047] As shown in the drawings, Figure 14 , 15 there is a mixing vessel box 101 capable of stacking multiple mixing vessels 10, the rack 1 is provided with a placing table for placing the vessel box, and the shell 2 is provided with a replacement opening opposite the placing table and a replacement door capable of opening and closing to block the replacement opening, so as to replace the vessel box. The bottom of the vessel box is open, and the two sides of the opening are provided with supporting plates supporting the two sides of the bottom surface of the mixing vessel, and the bottom of the side of the vessel box is provided with an outlet for outputting the mixing vessel; the top surface of the mixing vessel is provided with a plurality of sample grooves for storing liquid samples at intervals, which can be used to load mixed liquid multiple times, improve the convenience of use, and the larger mixing vessel has better stability during movement; the bottom surface of the mixing vessel is provided with a plurality of concave vessel body pushing grooves at intervals; the rack 1 is provided with a bottom plate, and the mixing vessel conveying mechanism 11 is provided with a conveying channel 111 on the bottom plate, a vessel body pushing block 112 capable of extending into the vessel body pushing groove in the conveying channel, and a vessel body driver 113 capable of driving the vessel body pushing block to move along the conveying channel, so as to accurately convey the mixing vessel; at the same time, the side of the bottom plate is provided with a waste guiding table 100, and the shell is provided with a waste outlet opposite the waste guiding table, and the shell is provided with a recycling box 200 outside for collecting waste, so as to collect various types of waste.

[0048] As shown in the drawings, Figure 14 , 16 there is a reagent box 401 capable of stacking multiple reagent cards 400, the bottom of the reagent box is open, and the two sides of the opening are provided with supporting plates supporting the two sides of the bottom surface of the reagent card, and the bottom of the side of the reagent box is provided with an outlet for outputting the reagent card; the rack 1 is provided with a reagent box placing table for placing a plurality of reagent boxes, and the shell 2 is provided with a replacement door capable of opening and closing to block the reagent box placing table, which also facilitates the replacement of the reagent box; the reagent card conveying mechanism 40 includes a movable card feeding horizontal carriage 402, the moving direction of the card feeding horizontal carriage is parallel to the arrangement direction of the reagent box, the card feeding horizontal carriage is provided with a card feeding longitudinal carriage 403, and the card feeding longitudinal carriage is provided with a reagent card pushing block 404 capable of extending into the reagent box and pushing the reagent card out, so as to accurately convey the reagent card. In addition, the reagent card 400 is also conveyed along the bottom plate, and there is also a reagent card recycling mechanism for sending the reagent card to the waste guiding table 100, so as to facilitate the recycling of waste and reduce the number of parts and the size of the equipment.

[0049] As shown in the drawings, Figure 17As shown, the reaction bin 50 includes an incubator 501 with one side opening, and the incubator is provided with a plurality of reaction bin groups, each reaction bin group is provided with a plurality of reaction chambers 502, the reaction chambers are arranged at the same side opening of the incubator, and a temperature controller is installed in the reaction chamber. Part or all of the adjacent reaction bin groups are provided with a partition layer 504 connected to the inner walls of the incubator, and the partition layer is provided with a chamber for placing the instrument. The reaction conveying mechanism 60 includes a gripper 601 for grabbing the reagent card, and a gripper driver 602 for driving the gripper to move opposite to the different reaction chambers. The partition layer of the incubator divides the interior of the incubator into a plurality of cavities, each cavity corresponds to an incubator; at the same time, different partition layers can be installed in the incubator as needed, and different temperature control devices can be installed at different positions of the incubator wall and in the partition layers; the reaction chambers of each reaction bin group are controlled by different temperature controllers to form different constant temperature environments for the reaction bin groups to meet the detection needs of different samples; and the gripper for grabbing the reagent card is opposite to the opening side of the incubator and the opening of the reaction chamber, and can put the reagent card into the reaction chamber or take out the reagent card in the reaction chamber under the driving of the gripper driver. The reaction bin has a three-dimensional structure, which can not only increase the number of chambers for placing reagent cards and improve work efficiency, but also form different incubation environments for the reaction bin groups to meet different detection requirements of different reagent cards; in addition, each reaction chamber is arranged relatively independently, and each reaction chamber can place a reagent card, the chamber wall of the chamber can protect and limit the reagent card, the placement of the reagent card is more convenient, the precision requirement of the equipment is lower, and the reagent cards are not easy to confuse, which is conducive to improving the convenience of reagent card placement and work accuracy and stability.

[0050] The chamber of the partition layer 504 is provided with an opening at one side, and the incubator 501 is provided with a heat dissipation air port 505 opposite to the opening to discharge excess heat and maintain the reaction chamber at a constant temperature. The inner cavity of the reaction chamber 502 is horizontally arranged in the middle, and the opening side of the inner cavity is inclined downward from inside to outside, so that the end of the reagent card placed in the reaction chamber is suspended, thereby facilitating the clamping of the gripper; at the same time, the side wall at the opening side of the reaction chamber 502 is also inclined, so that it can guide the reagent card placed therein, improve the convenience of placing the reagent card, and further reduce the precision requirement.

[0051] As shown in the drawings, Figure 18As shown, the gripper 601 comprises two upper and lower oppositely arranged clamping plates 603, because the reagent card is horizontally placed in a flat shape, the upper and lower oppositely arranged clamping plates can conveniently clamp the reagent card, and at least one of the two clamping plates is provided with a groove or anti-skid pattern on the adjacent side, so as to more stably clamp the reagent card. The gripper drive 602 comprises a gripper transverse moving frame 604 moving in the transverse direction, a gripper longitudinal moving frame 605 mounted on the gripper transverse moving frame and longitudinally moving, and a vertical moving frame 606 mounted on the gripper longitudinal moving frame and vertically moving, thereby forming a three-dimensional moving drive structure, and the gripper 601 is mounted on the vertical moving frame, so as to drive the gripper to realize three-dimensional movement in the transverse direction, the longitudinal direction and the vertical direction, and then accurately clamp or place the reagent card.

[0052] The transverse moving frame, the longitudinal moving frame and the vertical moving frame of each mechanism can be mounted on the guide rail through a sliding block, and are driven to move along the guide rail through corresponding motors, conveying belts and the like transmission members, so as to improve the working precision; which is prior art, and will not be described here.

[0053] The full-automatic fluorescence immunoassay analyzer comprises a cleaning tank containing cleaning liquid, pipelines respectively connected with the sampling needle 81, the liquid taking needle 20 and the mixing needle 30, a water pump connected with the pipelines and used for pumping the cleaning liquid from the cleaning tank to the sampling needle, the liquid taking needle or the mixing needle, and an air pump used for blowing air into the cleaning tank; the cleaning liquid is sprayed out after entering the sampling needle, the liquid taking needle or the mixing needle from the cleaning tank through the pipelines, so as to clean the inner wall of each needle; meanwhile, the sampling drive mechanism 82, the liquid taking drive mechanism 21 and the mixing drive mechanism 31 drive the sampling needle, the liquid taking needle and the mixing needle to extend into the cleaning tank respectively, the water pump sprays air into the cleaning tank and makes the cleaning liquid surge, so as to clean the outer wall of each needle, thereby completing the cleaning of the inner and outer walls of the needle, ensuring the cleanliness of the needle and avoiding affecting the accuracy of detection.

[0054] The above only describes the preferred embodiments of the present application, and does not limit the patent scope of the present application, and any equivalent structural transformation made according to the contents of the present application specification and drawings, or direct / indirect application in other related technical fields is included in the patent protection scope of the present application.

Claims

1. A fully automated fluorescent immunoassay analyzer characterized in that: The device comprises a rack (1) and a shell (2) covering the rack; one side of the rack is provided with a conveying platform for conveying a test tube rack and a test tube rack conveying mechanism; the shell is provided with a sampling port opposite to the middle part of the conveying platform; the rack is provided with a shaking manipulator (71) for taking and shaking sample tubes from the test tube rack, a sampling needle (81) capable of penetrating the cap of the sample tube and extending into the sample tube, a shaking driving mechanism (72) for driving the shaking manipulator to move, and a sampling driving mechanism (82) for driving the sampling needle to move; the rack is further provided with a reagent box (9) for containing reagents, a mixing dish conveying mechanism (11) for conveying a mixing dish (10), a liquid taking needle (20) for taking reagents from the reagent box and delivering the reagents to the mixing dish, a liquid taking driving mechanism (21) for driving the liquid taking needle to work, a mixing needle (30) for taking mixed liquid from the mixing dish, a mixing driving mechanism (31) for driving the mixing needle to work, a reagent card conveying mechanism (40) for conveying a reagent card, a reaction chamber (50) for providing a constant temperature environment for the reagent card, a reaction conveying mechanism (60) for taking and placing the reagent card from and in the reaction chamber, a reagent card detector for detecting the result of the reagent card and saving the detection result, and a cleaning mechanism for cleaning the sampling needle, the liquid taking needle and the mixing needle; the sampling driving mechanism and the liquid taking driving mechanism drive the sampling needle and the liquid taking needle to deliver blood samples and reagents to the mixing dish, the mixing driving mechanism drives the mixing needle to take mixed liquid from the mixing dish and deliver the mixed liquid to the reagent card, and the reaction conveying mechanism delivers the reagent card into the reaction chamber and delivers the reagent card after the reaction to the reagent card detector.

2. The fully automatic fluorescent immunoassay analyzer according to claim 1, characterized by: The conveying platform is provided with an inlet platform (41) and an outlet platform (51) for placing more than two test tube racks (3) side by side, and an inner side of a middle part of the conveying platform is a detection channel (61) for conveying the test tube rack; the test tube rack conveying mechanism drives the test tube rack to move along the inlet platform, the detection channel and the outlet platform; the sampling port of the shell is arranged opposite to the detection channel.

3. The fully automatic fluorescent immunoassay analyzer according to claim 2, characterized by: The test tube rack conveying mechanism comprises an inlet conveying mechanism (42), an outlet conveying mechanism (52) and a detection conveying mechanism (62) for driving the test tube rack (3) to move along the inlet platform (41), the outlet platform (51) and the detection channel (61) respectively.

4. The fully automatic fluorescent immunoassay analyzer according to claim 2, characterized by: The rack (1) is provided with a direction adjusting mechanism (80) at the sampling port of the shell (2) for adjusting the direction of the sample tube; the direction adjusting mechanism comprises rotatable direction adjusting wheels (801) and pressing wheels (802) arranged on both sides of the inlet end of the detection channel (61); the axes of the direction adjusting wheels and the pressing wheels are vertically arranged; the direction adjusting mechanism further comprises a direction adjusting motor one (803) for driving the pressing wheels to push the sample tube to contact with the direction adjusting wheels, a direction adjusting motor two (804) for driving the direction adjusting wheels to rotate and drive the sample tube to rotate, and a reader for detecting the label information on the sample tube.

5. The fully automated fluorescent immunoassay analyzer according to claim 2, 3 or 4, characterized in that: The inlet platform (41) and the outlet platform (42) are provided with a queue detection frame (91) and a queue detection seat (92) for placing the sample tube; the queue detection seat is movably arranged on the queue detection frame opposite to the sampling needle (81), and the moving direction of the queue detection seat is perpendicular to the detection channel (63).

6. The fully automatic fluorescent immunoassay analyzer according to claim 1, characterized by: The shaking mechanical hand (71) comprises two shaking clamps (77) arranged oppositely, one end of the two shaking clamps is rotatably connected to a shaking rotating shaft (78), a torsional spring (79) is sleeved on the shaking rotating shaft, one end of the torsional spring is fixedly arranged, and the other end is lower than the outer side of the shaking clamps, and the inner side of the other end of the two shaking clamps is provided with a groove for clamping a sample tube.

7. The fully automatic fluorescent immunoassay analyzer according to claim 1, characterized by: The mixing vessel box (101) can stack multiple mixing vessels (10), the bottom of the mixing vessel box is open, and supporting plates supporting two sides of the bottom surface of the mixing vessel are arranged on both sides of the opening; the bottom of the side surface of the mixing vessel box is provided with an outlet for outputting the mixing vessel; the top surface of the mixing vessel is provided with a plurality of sample grooves for storing liquid samples at intervals; the bottom surface of the mixing vessel is provided with a plurality of concave vessel body pushing recesses at intervals; the rack (1) is provided with a bottom plate, a vessel body pushing block (112) arranged in a conveying channel (111) on the bottom plate and capable of extending into the vessel body pushing recess, and a vessel body driver (113) driving the vessel body pushing block to move along the conveying channel.

8. The fully automatic fluorescent immunoassay analyzer according to claim 1, characterized by: The reagent box (401) can stack multiple reagent cards (400), the bottom of the reagent box is open, and supporting plates supporting two sides of the bottom surface of the reagent card are arranged on both sides of the opening; the bottom of the side surface of the reagent box is provided with an outlet for outputting the reagent card; the reagent card conveying mechanism (40) comprises a movable card feeding cross-moving frame (402), the moving direction of the card feeding cross-moving frame is parallel to the arrangement direction of the reagent box, the card feeding cross-moving frame is provided with a card feeding longitudinal-moving frame (403), and the card feeding longitudinal-moving frame is provided with a reagent card pushing block (404) capable of extending into the reagent box and pushing the reagent card out.

9. The fully automatic fluorescent immunoassay analyzer according to claim 1, characterized by: The reaction bin (50) comprises a heat preservation box (501) with one side open, a plurality of reaction bin groups are arranged in the heat preservation box, each reaction bin group is provided with a plurality of reaction chambers (502), the reaction chambers are arranged on the same side as the open side of the heat preservation box, and a temperature controller is arranged in each reaction chamber; a partition layer (504) connecting the inner walls of the heat preservation box is arranged between part or all of the adjacent reaction bin groups, and a chamber for placing instruments is arranged in the partition layer.

10. The fully automated fluorescent immunoassay analyzer according to claim 1, characterized in that: The cleaning mechanism comprises a cleaning pool containing cleaning liquid, pipelines respectively connected with the sampling needle (81), the liquid taking needle (20) and the mixing needle (30), a water pump connected with the pipelines and used for pumping the cleaning liquid from the cleaning pool to the sampling needle, the liquid taking needle or the mixing needle, and an air pump used for blowing air into the cleaning pool; the cleaning liquid is sprayed out after entering the sampling needle, the liquid taking needle or the mixing needle from the cleaning pool through the pipelines; the sampling driving mechanism (82), the liquid taking driving mechanism (21) and the mixing driving mechanism (31) respectively drive the sampling needle, the liquid taking needle and the mixing needle to extend into the cleaning pool; and the water pump sprays air into the cleaning pool and makes the cleaning liquid surge.

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