Compositions and uses thereof to help maintain healthy levels of blood lipids and blood glucose

Abstract

The present application provides a composition for maintaining healthy levels of blood lipids and blood sugar and application thereof. The composition of the present application comprises Ganoderma lucidum and / or extract thereof and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum and / or extract thereof to pentadecanoic acid is 1:(4-20). The present application also provides food containing the composition, and application of the composition or food in preparing products for maintaining healthy levels of blood lipids and blood sugar.

Description

Technical Field

[0001] This invention relates to the field of functional nutrient research technology, specifically to a composition that helps maintain healthy levels of blood lipids and blood sugar, and its application. Background Technology

[0002] With changes in people's lifestyles and the accelerating aging of the population, the incidence of hyperlipidemia and hyperglycemia is rising year by year. Among them, dyslipidemia is a major risk factor for cardiovascular disease, and hyperglycemia is a major risk factor for diabetes.

[0003] To assist in the prevention and control of cardiovascular disease and diabetes, improve daily diet, enhance nutritional health, and develop safe and effective management strategies for maintaining healthy blood lipid and blood glucose levels, it is of great significance for minimizing the occurrence of cardiovascular events and diabetes and improving overall health. Summary of the Invention

[0004] One object of the present invention is to provide a composition that helps maintain healthy levels of blood lipids and / or blood sugar.

[0005] Another object of the present invention is to provide relevant applications of the composition.

[0006] The present invention aims to provide a safe and effective composition that can effectively maintain healthy levels of blood lipids and / or blood glucose.

[0007] The inventors of this case have discovered that Ganoderma lucidum and / or its extracts, in combination with pentadecanoic acid, or in further combination with Ganoderma lucidum and / or its extracts, can maintain healthy levels of blood lipids and / or blood sugar, exhibiting a synergistic effect.

[0008] On one hand, the present invention provides the use of a composition comprising Ganoderma lucidum and / or its extracts and pentadecanoic acid in the preparation of products that help maintain healthy levels of blood lipids and / or blood sugar, wherein the mass ratio of Ganoderma lucidum and / or its extracts to pentadecanoic acid is 1:(4-20).

[0009] On the other hand, the present invention also provides the use of a food in the preparation of products that help maintain healthy levels of blood lipids and / or blood sugar, the food containing a composition comprising Ganoderma lucidum and / or its extracts and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum and / or its extracts to pentadecanoic acid is 1:(4-20).

[0010] On the other hand, the present invention also provides a composition that helps maintain healthy levels of blood lipids and / or blood sugar, the composition comprising Ganoderma lucidum and / or its extracts and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum and / or its extracts to pentadecanoic acid is 1:(4-20).

[0011] On the other hand, the present invention also provides a food that helps maintain healthy levels of blood lipids and / or blood sugar, the food containing the composition of the present invention that helps maintain healthy levels of blood lipids and / or blood sugar, wherein the amount of Ganoderma lucidum and / or its extract in the food is 0.01-1g / 100g of dry matter.

[0012] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract to pentadecanoic acid is 1:(6-18).

[0013] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract to pentadecanoic acid is 1:(8-16).

[0014] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract to pentadecanoic acid is 1:(6-10).

[0015] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract to pentadecanoic acid is 1:(14-18).

[0016] According to some specific embodiments of the present invention, the composition of the present invention further includes Solomon's seal and / or its extract, wherein the mass ratio of Solomon's seal and / or its extract to pentadecanoic acid is 1:(2-6).

[0017] According to some specific embodiments of the present invention, the composition of the present invention further includes Solomon's seal and / or its extract, wherein the mass ratio of Solomon's seal and / or its extract to pentadecanoic acid is 1:(3-5).

[0018] According to some specific embodiments of the present invention, the composition of the present invention further includes Solomon's seal and / or its extract, wherein the mass ratio of Solomon's seal and / or its extract to pentadecanoic acid is 1:4.

[0019] According to some specific embodiments of the present invention, the composition of the present invention consists of Ganoderma lucidum and / or its extracts with pentadecanoic acid.

[0020] According to some specific embodiments of the present invention, the composition of the present invention consists of Ganoderma lucidum and / or its extracts, Polygonatum odoratum and / or its extracts, and pentadecanoic acid.

[0021] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract, Polygonatum odoratum and / or its extract to pentadecanoic acid is 1:(1-5):(4-20).

[0022] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of Ganoderma lucidum and / or its extract, Polygonatum odoratum and / or its extract to pentadecanoic acid is 1:(2-4):(8-16).

[0023] According to a specific embodiment of the present invention, Ganoderma lucidum can be directly made into ultrafine powder for use in the composition of the present invention, or Ganoderma lucidum extract can be used.

[0024] According to some specific embodiments of the present invention, the Ganoderma lucidum extract of the present invention is an aqueous extract of Ganoderma lucidum, wherein Ganoderma lucidum polysaccharides ≥8%; triterpenes and sterols ≥0.8%. In some specific embodiments, the Ganoderma lucidum extract is a powdered solid, and its preparation process is as follows: Ganoderma lucidum is pulverized through a 20-60 mesh sieve, 10-30 times its weight of distilled water is added, soaked for 20 min-3 h, decocted for 30-60 min, the decoction is filtered, the filtrate is concentrated under reduced pressure and then dried in an oven at 35-55℃ to obtain the Ganoderma lucidum extract.

[0025] According to a specific embodiment of the present invention, the Solomon's Seal can be directly made into an ultrafine powder for use in the composition of the present invention, or the present invention can use Solomon's Seal extract.

[0026] According to some specific embodiments of the present invention, the Polygonatum odoratum extract of the present invention is an aqueous extract of Polygonatum odoratum, wherein the Polygonatum odoratum polysaccharide content is ≥8%. In some specific embodiments, the Polygonatum odoratum extract is a powdered solid, and its preparation process is as follows: Polygonatum odoratum is pulverized through a 20-60 mesh sieve, 2-6 times its weight of distilled water is added, soaked for 20 min-3 h, decocted for 30-60 min, the decoction is filtered, the filtrate is concentrated under reduced pressure, and then dried in an oven at 35-55℃ to obtain the Polygonatum odoratum extract.

[0027] According to some specific embodiments of the present invention, the food of the present invention is a nutritional product, health food, or food for special medical purposes. The nutritional product, health food, or food for special medical purposes may be in the form of oral liquid, powder, capsule, etc. The nutritional product described in the present invention refers to an oral product that, with the purpose and mission of nutritional science, can provide or develop human nutritional and health potential, and helps individuals to be in a good nutritional state, thereby contributing to individual health.

[0028] According to some specific embodiments of the present invention, the food of the present invention is a dairy product, such as liquid milk, modified milk, yogurt, cheese, modified milk powder, milk powder, milk beverage, solid beverage, convenience food or candy.

[0029] According to some specific embodiments of the present invention, the food of the present invention is adult-modified milk powder, such as milk powder for middle-aged and elderly people.

[0030] According to some specific embodiments of the present invention, the amount of Ganoderma lucidum and / or its extracts in the food of the present invention is 0.01-1g / 100g of dry matter. For example, it can be 0.01-0.03g / 100g, 0.03-0.08g / 100g, 0.08-0.12g / 100g, 0.12-0.2g / 100g, 0.2-0.5g / 100g, or 0.5-1.0g / 100g.

[0031] According to some specific embodiments of the present invention, the content of pentadecanoic acid, Solomon's seal and / or its extracts in food can be determined with reference to the proportions in the composition.

[0032] According to some specific embodiments of the present invention, the amount of pentadecanoic acid in the food of the present invention is 0.04-2 g / 100 g. For example, it can be 0.04-0.08 g / 100 g, 0.08-0.12 g / 100 g, 0.12-0.2 g / 100 g, 0.2-0.5 g / 100 g, 0.5-1.0 g / 100 g, or 1.0-2.0 g / 100 g.

[0033] According to some specific embodiments of the present invention, the amount of Solomon's seal and / or its extract in the food of the present invention is 0.01-4 g / 100g of dry matter. For example, it can be 0.01-0.03 g / 100g, 0.03-0.08 g / 100g, 0.08-0.12 g / 100g, 0.12-0.2 g / 100g, 0.2-1.0 g / 100g, 1.0-2.0 g / 100g, 2.0-3.0 g / 100g, or 3.0-4.0 g / 100g.

[0034] It is understandable that, for different types of food, the content of various functional substances in the final product should be appropriately adjusted within the range allowed by relevant standards and regulations.

[0035] According to some specific embodiments of the present invention, in applications of the present invention, the product helps maintain healthy triglyceride levels.

[0036] According to some specific embodiments of the present invention, in applications of the present invention, the product helps maintain healthy levels of glucose and / or insulin in the body.

[0037] According to some specific embodiments of the present invention, in applications of the present invention, the product helps maintain healthy levels of blood lipids and blood sugar.

[0038] According to some specific embodiments of the present invention, in applications of the present invention, the individual is a person or an animal. The person may be, for example, a child, adolescent, or adult (e.g., middle-aged or elderly person). The animal is preferably a mammal.

[0039] According to some specific embodiments of the present invention, the product may be any of the aforementioned food products, or food products made from the aforementioned composition and / or food products without or with the addition of other substances through further processing.

[0040] According to some specific embodiments of the present invention, the product can be a pharmaceutical product used to treat patients with dyslipidemia and / or diabetes. In addition to the Ganoderma lucidum and / or its extracts, Polygonatum odoratum and / or its extracts, and pentadecanoic acid, the pharmaceutical product of the present invention may also include pharmaceutically acceptable excipients, including excipients, diluents, fillers, and / or absorption enhancers. The pharmaceutical product may be in different forms according to the needs of the recipient, such as powders, tablets, granules, microcapsules, and / or liquid formulations.

[0041] In summary, the composition and food containing Ganoderma lucidum and / or its extracts, Polygonatum odoratum and / or its extracts, and pentadecanoic acid provided by the present invention help maintain healthy levels of blood lipids and blood sugar, and have a certain synergistic effect. Attached Figure Description

[0042] Figure 1 This shows the intensity of triglyceride staining in the blood vessels of zebrafish tails after sample processing (two sides).

[0043] Figure 2 This shows the glucose levels in zebrafish after sample treatment (two sides).

[0044] Figure 3 This shows the insulin levels in zebrafish after sample treatment (two sides).

[0045] Figure 4 This shows the staining intensity of triglycerides in the blood vessels of zebrafish tails after sample processing (three-sided).

[0046] Figure 5 This shows the glucose levels in zebrafish after sample treatment (three-dimensional).

[0047] Figure 6 This shows the insulin levels in zebrafish after sample treatment (three-dimensional). Detailed Implementation

[0048] Before further describing specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terminology used in the embodiments of the present invention is for describing specific embodiments and not for limiting the scope of protection of the present invention.

[0049] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the present invention, the two endpoints of each numerical range and any value between the two endpoints may be selected.

[0050] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art.

[0051] Before further describing specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terminology used in the embodiments of the present invention is for describing specific embodiments and not for limiting the scope of protection of the present invention.

[0052] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the present invention, the two endpoints of each numerical range and any value between the two endpoints may be selected.

[0053] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art.

[0054] As used herein, the term "individual" means any animal or human who may benefit from the products of this invention that help maintain healthy lipid levels and / or healthy blood sugar levels. Generally, when an individual is a human, it can be an infant, child, adolescent, or adult, such as a middle-aged or elderly person. The term "infant" refers to a human being aged 0-3 years from birth, the term "child" refers to a human being aged 3-15 years from birth, the term "adolescent" refers to a human being aged 12-18 years from birth, the term "adult" refers to a human being aged 18 years or older from birth, and the term "middle-aged or elderly person" refers to a human being aged 40 years or older from birth.

[0055] In addition to the specific methods, equipment, and materials used in the embodiments, based on the knowledge of those skilled in the art and the description of this invention, any prior art methods, equipment, and materials similar to or equivalent to those described, equipment, and materials in the embodiments of this invention can be used to implement this invention.

[0056] Experimental study on the efficacy of the composition in improving individual blood lipids and blood sugar.

[0057] 1. Experimental Materials

[0058] 1.1 Sample Preparation Information

[0059] Pentadecanoic acid: Commercially available food-grade pure product.

[0060] Ganoderma lucidum extract, a powdery solid, wherein the polysaccharide of Ganoderma lucidum ≥ 8%; triterpenoids and sterols ≥ 0.8%. Its preparation method: Ganoderma lucidum is crushed and passed through a 40-mesh sieve, added with 20 times the weight of distilled water, soaked for 1 h, decocted for 50 min, the decoction is filtered, the filtrate is concentrated under reduced pressure to 2 g / ml, and then dried in an oven at 45 °C to obtain the said Ganoderma lucidum extract, with a yield of 5%.

[0061] Polygonatum odoratum extract, a powdery solid, wherein the polysaccharide of Polygonatum odoratum ≥ 8%. Its preparation method: Polygonatum odoratum is crushed and passed through a 40-mesh sieve, added with 4 times the weight of distilled water, soaked for 1 h, decocted for 50 min, the decoction is filtered, the filtrate is concentrated under reduced pressure to 2 g / ml, and then dried in an oven at 45 °C to obtain the said Polygonatum odoratum extract, with a yield of 25%.

[0062] Positive control: Pioglitazone Hydrochloride Tablets (hereinafter referred to as pioglitazone), white tablets, batch number 20220503, Jiangsu Deyuan Pharmaceutical Co., Ltd., stored in a cool and dark place. Prepared into a 10.0 mg / mL stock solution with ultrapure water and used immediately.

[0063] 1.2 Experimental animals

[0064] Zebrafish are all raised in fish-raising water at 28 °C (water quality: 200 mg of instant sea salt is added to every 1 L of reverse osmosis water, the conductivity is 450 - 550 μS / cm; pH is 6.5 - 8.5; hardness is 50 - 100 mg / L CaCO3), provided by the fish-raising center of Hangzhou Huante Biotechnology Co., Ltd., and the experimental animal use license number is: SYXK (Zhe) 2022 - 0004. The feeding management meets the requirements of international AAALAC certification (certification number: 001458).

[0065] Wild-type AB strain zebrafish, reproduced by natural paired mating. Zebrafish at 5 days post-fertilization (5 dpf) are used for efficacy evaluation.

[0066] 1.3 Instruments, consumables and reagents

[0067] Dissecting microscope (SZX7, OLYMPUS, Japan); Microinjector (IM300, Narishige, Japan); Needle puller (PC-10, Narishige, Japan); CCD camera (VertA1, Shanghai Tusen Vision Technology Co., Ltd., China); Motorized focusing continuous zoom fluorescence microscope (AZ100, Nikon, Japan); Precision electronic balance (CP214, OHAUS, USA); 6-well plate (Nest Biotech, China); Fully automated rapid sample grinder (JXFSTPRP-24L, Shanghai Jingxin Experimental Equipment Technology Department, China); High-speed refrigerated centrifuge (Heraeus Fresco17, Thermo). Fisher, Germany); Homogenizer (T10, IKA, Germany); Ultrasonic cleaner (JP-010T, Shenzhen Jiemeng Cleaning Equipment Co., Ltd., China); Automated nucleic acid extractor (Auto-Pure32A, Hangzhou Aosheng Instrument Co., Ltd., China); Conventional PCR amplification instrument (T100, BIO-RAD, Singapore); Real-time PCR instrument (CFX Connect, BIO-RAD, Singapore); UV-Vis spectrophotometer (Nanodrop2000, Thermo, Austria); Microplate mini centrifuge (BE-6100, Haimen Qilinbei Instrument Manufacturing Co., Ltd., China); Optical adhesive sealing film B (MSB1001, Bio-rad, USA); Low-skirted 96-well plate (transparent) (HSP9601, Bio-rad, USA).

[0068] CholesterlylBODIPY™ 542 / 563 C11 (cholesterol probe, lot number 2291600, Invitrogen, USA); Pure egg yolk powder (lot number 20200809, Zhejiang Agribusiness Biotechnology Co., Ltd., China); D-(+)-glucose (lot number F2209126, Shanghai Aladdin Biochemical Technology Co., Ltd., China); Anhydrous ethanol (lot number 20210107, Sinopharm Chemical Reagent Co., Ltd., China); Dimethyl sulfoxide (DMSO, lot number BCCD8942, Sigma, Switzerland); Methylcellulose (lot number C2004046, Shanghai Aladdin Biochemical Technology Co., Ltd., China); ChamQ Universal SYBR qPCR Master Mix (batch number 027E2201CD, Vazyme, China); FastKingcDNA First Strand Synthesis Kit (Genomic De-generated) (batch number X0320, Tiangen Biotech (Beijing) Co., Ltd., China); Pre-loaded Magnetic Bead Universal RNA Extraction Kit C (batch number TL2210001643C, Foshan ONREW Biotechnology Co., Ltd., China).

[0069] 2. Experimental Methods

[0070] Thirty zebrafish were used in each experimental group, and the samples were administered in water (the concentrations of each single or combined sample in the feeding system are detailed in Table 1). A positive control of pioglitazone hydrochloride at a concentration of 20.0 μg / mL was used, along with a normal control group and a model control group. Except for the normal control group, the other experimental groups were administered a 0.15% egg yolk powder solution in water during the day and a 3% glucose solution in water at night to establish a zebrafish hyperglycemia and hyperlipidemia model.

[0071] After treatment at 28℃ for 48 hours, the zebrafish were washed three times with fish tank water. The overall glucose level of the zebrafish was measured using a blood glucose meter, and the glucose levels were analyzed and statistically analyzed. The insulin levels of the zebrafish were also analyzed and statistically analyzed using a zebrafish insulin level detection kit. The statistical analysis results of the indicators were used to evaluate the auxiliary hypoglycemic effect of the samples.

[0072] The samples were fixed with tissue cell fixative, and then stained with Oil Red O for overall fat staining. Ten zebrafish were randomly selected from each experimental group and photographed under a dissecting microscope. Advanced image processing software was used to analyze and collect data. The staining intensity of triglycerides in the blood vessels of the zebrafish tail was analyzed, and the statistical analysis results of this index were used to evaluate the lipid-lowering effect of the samples.

[0073] Statistical results are expressed as mean ± SE. Statistical analysis was performed using SPSS 26.0 software, and p < 0.05 was considered statistically significant.

[0074] 3. Experimental Results

[0075] The experimental results are recorded in Tables 1 to 3.

[0076] Table 1. Results of the blood glucose lowering experiment on the samples

[0077]

[0078] Compared with the model control group, p < 0.05, p < 0.01, p < 0.001.

[0079] Table 2. Results of experiments on increasing insulin content in samples

[0080]

[0081] Compared with the model control group, p < 0.05, p < 0.01, p < 0.001.

[0082] Table 3 Results of Triglyceride-Lowering Experiments on Samples

[0083]

[0084] Compared with the model control group, p < 0.05, p < 0.001.

[0085] See Figures 1-3 In the figure, compared with the model control group, p < 0.05, p < 0.01, p < 0.001; compared with Ganoderma lucidum powder and pentadecanoic acid, #p < 0.05, ##p < 0.01, ###p < 0.001. It can be seen that the combination of the two ingredients in this invention (Ganoderma lucidum extract and pentadecanoic acid) has a synergistic effect on maintaining healthy blood lipid levels and maintaining healthy blood sugar levels.

[0086] See Figures 4-6 In the figure, compared with the model control group, p < 0.05, p < 0.01, p < 0.001; compared with Ganoderma lucidum powder, #p < 0.05, ##p < 0.01, ###p < 0.001; compared with Polygonatum odoratum powder, &p < 0.05, &&p < 0.01, &&&p < 0.001; compared with pentadecanoic acid, @p < 0.05, @@p < 0.01, @@@p < 0.001. It can be seen that the three-component combination of the present invention (Ganoderma lucidum extract, Polygonatum odoratum extract, and pentadecanoic acid) has a synergistic effect on maintaining healthy blood lipid levels and maintaining healthy blood sugar levels.

[0087] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. The use of a composition in the preparation of products that help maintain healthy levels of blood lipids and / or blood glucose, characterized in that, The composition comprises Ganoderma lucidum extract and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum extract to pentadecanoic acid is 1:(6-10). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum.

2. The use of a composition in the preparation of products that help maintain healthy levels of blood lipids and / or blood glucose, characterized in that, The composition comprises Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid is 1:(1-5):(4-20). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum. The Solomon's Seal Extract is an aqueous extract of Solomon's Seal.

3. The use of a food product in the preparation of products that help maintain healthy levels of blood lipids and / or blood sugar, characterized in that, The food uses only one composition as an active ingredient that helps maintain healthy blood lipid and / or blood sugar levels. The composition consists of Ganoderma lucidum extract and pentadecanoic acid, with the mass ratio of Ganoderma lucidum extract to pentadecanoic acid being 1:(6-10). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum. The amount of Ganoderma lucidum extract in the food is 0.01-1g / 100g of dry matter, and the amount of pentadecanoic acid is 0.04-2g / 100g of dry matter.

4. The use of a food product in the preparation of products that help maintain healthy levels of blood lipids and / or blood sugar, characterized in that, The food uses only one composition as an active ingredient that helps maintain healthy levels of blood lipids and / or blood sugar. The composition consists of Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid, with a mass ratio of Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid of 1:(1-5):(4-20). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum. The Polygonatum odoratum extract is an aqueous extract of Polygonatum odoratum. The amount of Ganoderma lucidum extract in the food is 0.01-1g / 100g of dry matter, the amount of Polygonatum odoratum extract is 0.01-4g / 100g of dry matter, and the amount of pentadecanoic acid is 0.04-2g / 100g of dry matter.

5. The application according to any one of claims 3-4, characterized in that, Foods containing the aforementioned composition are nutritional supplements, health foods, or foods formulated for special medical purposes.

6. The application according to any one of claims 1-4, characterized in that, The product helps maintain healthy triglyceride levels.

7. The application according to any one of claims 1-4, characterized in that, The product helps maintain healthy glucose levels in the body.

8. A composition that helps maintain healthy levels of blood lipids and / or blood glucose, characterized in that, The composition consists of Ganoderma lucidum extract and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum extract to pentadecanoic acid is 1:(6-10). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum.

9. A composition that helps maintain healthy levels of blood lipids and / or blood glucose, characterized in that, The composition comprises Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid, wherein the mass ratio of Ganoderma lucidum extract, Polygonatum odoratum extract and pentadecanoic acid is 1:(1-5):(4-20). The Ganoderma lucidum extract is an aqueous extract of Ganoderma lucidum. The Solomon's Seal Extract is an aqueous extract of Solomon's Seal.

10. A food that helps maintain healthy levels of blood lipids and / or blood sugar, characterized in that, The food uses only the composition of claim 8 as an active ingredient that helps maintain healthy blood lipid and / or blood glucose levels, wherein the amount of Ganoderma lucidum extract in the food is 0.01-1g / 100g of dry matter.

11. A food that helps maintain healthy levels of blood lipids and / or blood sugar, characterized in that, The food product uses only the composition of claim 9 as an active ingredient that helps maintain healthy blood lipid and / or blood glucose levels, wherein the food product contains 0.01-1g of Ganoderma lucidum extract per 100g of dry matter, 0.01-4g of Polygonatum odoratum extract per 100g of dry matter, and 0.04-2g of pentadecanoic acid per 100g of dry matter.

12. The food product according to claim 10 or 11, characterized in that, The food products mentioned are nutritional products, health foods, or foods formulated for special medical purposes.

13. The food product according to claim 10 or 11, characterized in that, The food product is adult formulated milk powder.

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