Outdoor electrostatic spinning device for in-situ deposition of fiber dressing

Abstract

The invention provides an outdoor electrostatic spinning device for in-situ deposition of a fiber dressing, and relates to the field of medical instruments. The device comprises an outer shell, an injection pipe group and a directional safety cover, a pushing and injecting mechanism and a power supply mechanism are arranged in the outer shell; the pushing and injecting mechanism comprises a liquid storage cavity and a driving part; the liquid inlet end of the injection pipe set is located in the outer shell and connected with the liquid storage cavity, and the liquid outlet end of the injection pipe set is located outside the outer shell. The side wall of the injection pipe group is connected with the power supply mechanism, and a conducting strip is arranged in the side wall of the injection pipe group outside the outer shell; a needle head is detachably arranged at the liquid outlet end of the injection pipe; the directional safety cover is arranged on the side wall of the outer shell and comprises an insulating cover and a conductor cover located in the insulating cover. Materials such as medical glue can be injected to form effective dressing, and the dressing is suitable for military actions and outdoor activities, achieves rapid and emergency nursing, has the effects of sealing wounds and achieving bacterium blocking and resisting, and is beneficial to follow-up wound retreatment.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and in particular to an electrospinning apparatus for in-situ deposited fiber dressings for outdoor use. Background Technology

[0002] Currently, the size and thickness of commercial dressings are generally controlled within a certain range. However, existing dressing products cannot meet the needs for timely care in scenarios such as military operations or outdoor activities involving large-area wounds or uneven wounds.

[0003] Electrospinning is a technique that uses a high-voltage electrostatic field to prepare ultrafine fibers. Due to its wide range of raw material selection, the micro and nanofiber materials prepared have high specific surface area and high porosity, and their physicochemical properties are adjustable and controllable. They can also mimic the structure of the extracellular matrix (ECM) and are widely used in biomedical fields such as wound dressings, anti-adhesion membranes, tissue repair membranes, drug sustained release systems, and artificial blood vessels.

[0004] In summary, there is an urgent need for an instant in-situ electrospinning system. Summary of the Invention

[0005] The electrospinning device for outdoor in-situ deposited fiber dressings provided by this invention can spray medical adhesives and other materials to form effective dressings. It is suitable for military operations and outdoor activities, enabling rapid and emergency care. It can seal wounds, achieve antibacterial and antimicrobial effects, and facilitate subsequent wound re-treatment.

[0006] The electrospinning device for in-situ deposited fiber dressings for outdoor use provided by this invention includes an outer shell, an injection tube assembly, and a directional safety cover. The outer shell houses an injection mechanism and a power supply mechanism. The injection mechanism includes a liquid storage chamber and a driving component. The power supply mechanism serves as the power source. The inlet end of the injection tube assembly is located inside the outer shell and connected to the liquid storage chamber, while the outlet end of the injection tube assembly is located outside the outer shell. The sidewall of the injection tube assembly is connected to the power supply mechanism, and a conductive sheet is provided in the sidewall of the injection tube assembly located outside the outer shell. A needle is detachably provided at the outlet end of the injection tube. The directional safety cover is located on the sidewall of the outer shell and includes an insulating cover and a conductor cover located inside the insulating cover. The injection tube assembly is located inside the conductor cover, and the conductive sheet is in contact with the conductor cover.

[0007] In one specific embodiment, the injection tube assembly includes an injection tube and an annular component. The inlet end of the injection tube is located inside the outer casing and connected to the liquid storage cavity, while the outlet end of the injection tube is located outside the outer casing. The annular component is arranged around the outer wall of the injection tube located outside the outer casing, and the outer wall of the annular component is provided with an annular groove. The conductive sheet is disposed in the annular groove.

[0008] In one specific embodiment, the inner diameter of the injection tube is 0.5~1.5 mm, the needle specification is 17~25G, and the diameter of the annular groove is 5~20 mm.

[0009] In one specific embodiment, the insulating cover includes an insulating truncated cone and an insulating column connected together, and the conductor cover includes a conductor truncated cone and a conductor column connected together; the conductor column is in contact with the outer wall of the injection pipe assembly, the insulating column is in contact with the conductor column, and the insulating truncated cone is in contact with the conductor truncated cone; the cone tips of the conductor truncated cone and the insulating truncated cone face the outer shell.

[0010] In one specific embodiment, the cone angle of the insulating truncated cone and the conductor truncated cone is 15~75°.

[0011] In one specific embodiment, the height of the conductor cone is 20-60 mm, and the height of the insulating cone is 100-200 mm.

[0012] In one specific embodiment, the insulating cover is made of a polymer material, the conductor cover is made of metal, the injection tube is made of metal, and the needle is made of metal.

[0013] In one specific embodiment, the outer casing includes a handheld part and a spinning part connected together, and the injection mechanism is located inside the spinning part; the power supply mechanism includes a battery, a high-voltage power generator and a voltage control module, the battery is located inside the handheld part, the high-voltage power generator and the voltage control module are located inside the spinning part, the high-voltage power generator is connected to the injection tube assembly, the battery serves as the power source, and the voltage control module is used to adjust the voltage of the high-voltage power generator.

[0014] In one specific embodiment, a knob is provided on the outer side wall of the housing, and the knob is connected to a voltage control module; and / or, a flexible solar panel is provided on the outer side wall of the housing, and the flexible solar panel is connected to a high-voltage power generator; and / or, a trigger is provided on the outer side wall of the housing, and the trigger is connected to a drive component.

[0015] The present invention also provides a method for using an electrospinning device for outdoor in-situ deposited fiber dressings, comprising the following steps: Step 1) Align the electrospinning device with the wound, and the drive unit pushes the injection fluid in the reservoir into the injection tube assembly; Step 2) The injection tube assembly fiberizes the flowing injection fluid and then sprays it out from the needle.

[0016] The electrospinning apparatus for outdoor in-situ deposited fiber dressings provided by this invention has the following beneficial effects: 1) This invention can spray materials such as chitosan, collagen, gelatin, and α-cyanoacrylate medical adhesives to form an effective dressing, suitable for military operations and outdoor activities, to achieve rapid and emergency care, and has the function of sealing wounds, achieving antibacterial and antimicrobial effects, which is beneficial for subsequent wound re-treatment.

[0017] 2) The directional safety cover in this invention can limit the deposition range of electrospun fibers, which can more effectively cover the wound; at the same time, when used outdoors, the directional safety cover can avoid interference from environmental factors such as wind, rain and snow. Attached Figure Description

[0018] Figure 1 This is an overall structural diagram of the present invention.

[0019] Figure 2 This is a cross-sectional view of the present invention.

[0020] Figure 3 This is a cross-sectional view of the directional safety shield and injection pipe assembly in this invention.

[0021] Figure 4 This is a cross-sectional view of the injection pipe assembly in this invention.

[0022] Figure Labels

[0023] Outer shell 1 Handheld part 11 Spinning section 12 Knob 13 Flexible solar panel 14 Trigger 15 Injection pipe assembly 2 Injection pipe 21 Injection lumen 21.1 Ring component 22 Annular groove 23 Conductive sheet 24 directional safety shield 3 Insulating cover 31 Insulated vertices 31.1 Insulating post 31.2 Conductor cover 32 Conductor cone 32.1 Conductor post 32.2 Injection agency 4 Liquid storage chamber 41 Drive component 42 Power supply mechanism 5 Battery 51 High voltage power generator 52 Voltage control module 53 Needle 6 Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "connected" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0026] This invention provides an electrospinning apparatus for in-situ deposited fiber dressings for outdoor use, such as... Figure 1 and Figure 2 As shown, it includes an outer casing 1, an injection tube assembly 2, and a directional safety cover 3. The outer casing 1 houses an injection mechanism 4 and a power supply mechanism 5. The injection mechanism 4 includes a liquid storage chamber 41 and a drive component 42. The drive component 42 typically includes a drive motor and a push plate that can be pushed by the drive motor. The liquid storage chamber 41 can be a detachable syringe. The push plate is used to push the piston rod of the syringe along the axial direction of the syringe, thereby ejecting the injection liquid. The power supply mechanism 5 serves as the power source. Figure 3 and Figure 4 As shown, the inlet end of the spray tube assembly 2 is located inside the outer shell 1 and connected to the liquid storage chamber 41, while the outlet end of the spray tube assembly 2 is located outside the outer shell 1, meaning the spray tube assembly 2 passes through the outer shell 1. Typically, a through hole is provided on the side wall of the outer shell 1 to allow the spray tube assembly 2 to pass through. Specifically, the spray tube assembly 2 includes a spray tube cavity 21.1, which is connected to the liquid storage chamber 41. If the liquid storage chamber 41 is a syringe, the needle 6 of the syringe can be inserted into the inlet end of the spray tube cavity 21.1 to achieve communication between the two. Figure 3 and Figure 4 As shown, the side wall of the injection tube assembly 2 is connected to the power supply mechanism 5, usually via a wire. After the injection tube assembly 2 is connected to the high voltage provided by the power supply mechanism 5, a high-voltage electrostatic field is formed, thereby causing the injection liquid flowing through the injection tube cavity 21.1 to become fibrous, achieving electrospinning to form a dressing. For example... Figure 2 and Figure 3As shown, a conductive sheet 23 is provided in the side wall of the injection tube assembly 2 located outside the outer shell 1. A needle 6 is detachably provided at the liquid outlet end of the injection tube 21, and the needle 6 is preferably made of metal. The directional safety cover 3 is provided on the side wall of the outer shell 1. The directional safety cover 3 includes an insulating cover 31 and a conductor cover 32 located inside the insulating cover 31. The term "inside" means that the conductor cover 32 does not exceed the area covered by the insulating cover 31, and in particular, the height of the conductor cover 32 does not exceed the height of the insulating cover 31. The height here is based on the injection direction of the spinning. The injection tube assembly 2 is located inside the conductor cover 32. The conductive sheet 23 is in contact with the conductor cover 32. The conductive sheet 23 is used to transmit high voltage to the conductor cover 32, so that the conductor cover 32 forms a high voltage electrostatic field, thereby limiting the fiber ejected from the needle 6.

[0027] Before use, the liquid storage chamber 41 is preloaded with the injection liquid. When in use, the injection mechanism 4 is activated so that the injection liquid in the liquid storage chamber 41 is pushed into the injection tube 21.1 at a certain speed. The injection liquid entering the injection tube 21.1 is fiberized under the action of the high voltage electrostatic field and then sprayed out from the needle 6.

[0028] As a supplementary explanation, the outer shell 1 is a detachable structure, which can be divided into two symmetrical shells. A syringe groove is provided on the inner wall of the outer shell 1 for placing and securing the syringe. The syringe can be a 5mL disposable syringe or a reusable syringe of the same specifications and dimensions.

[0029] In one specific embodiment, such as Figure 2 and Figure 3 As shown, the injection pipe assembly 2 includes an injection pipe 21 and an annular component 22. The inlet end of the injection pipe 21 is located inside the outer casing 1 and connected to the liquid storage chamber 41, while the outlet end of the injection pipe 21 is located outside the outer casing 1. The core component of the injection pipe assembly 2 is the injection pipe 21; therefore, the injection pipe cavity 21.1 actually refers to the cavity of the injection pipe 21. The annular component 22 is arranged around the outer wall of the injection pipe 21 located outside the outer casing 1. The outer wall of the annular component 22 has an annular groove 22.1, and the conductive sheet 23 is disposed in the annular groove 22.1.

[0030] The electrospinning apparatus provided in the embodiments of the present invention, such as Figure 3As shown, the insulating cover 31 includes an insulating truncated cone 31.1 and an insulating column 31.2 connected to each other, and the conductor cover 32 includes a conductor truncated cone 32.1 and a conductor column 32.2 connected to each other. The inner wall of the conductor column 32.2 is in contact with the outer wall of the injection pipe assembly 2, the inner wall of the insulating column 31.2 is in contact with the outer wall of the conductor column 32.2, and the inner wall of the insulating truncated cone 31.1 is in contact with the outer wall of the conductor truncated cone 32.1; the cone tips of the conductor truncated cone 32.1 and the insulating truncated cone 31.1 face the outer shell 1. For illustration, the conductor cover 32 is made of metal, and the insulating cover 31 is made of polymer, preferably a flexible polymer material such as polyurethane or silicone.

[0031] After the injection tube assembly 2 is connected to high voltage, the high voltage is transmitted to the conductor cover 32 via the conductive sheet 23, enabling the conductor cover 32 to also form a high-voltage electrostatic field. The fibers ejected from the needle tip 6 are typically spiral-shaped, and their spiral radius increases with the distance of the injection, resulting in a larger deposition area. The high-voltage electrostatic field formed by the conductor cover 32 can effectively suppress the spiral radius, confining the ejected fibers within a certain range, thereby forming an effective dressing. The insulating cover 31 also serves to limit the ejected fibers, but compared to the conductor cover 32, the insulating cover 31 uses a physical limiting method and is taller, further limiting the fiber coverage area on top of the conductor cover 32. In summary, the directional safety cover 3 can limit the deposition range of electrospun fibers, providing more effective wound coverage; at the same time, when used outdoors, the directional safety cover 3 can avoid interference from environmental factors such as wind, rain, and snow. Meanwhile, the annular part 22 is provided with a slot, and the conductor cover 32 can be snapped into the annular part 22. The conductor cover 32 is also provided with a slot, and the insulating cover 31 can be snapped into the conductor cover 32. When storing the device after use, the insulating cover 31 and the conductor cover 32 can be removed first to store them separately and reduce the overall volume of the electrospinning device.

[0032] In one specific embodiment, the inner diameter of the injection tube 21 is 0.5~1.5 mm, the material of the needle 6 is metal, the specification of the needle is 17~25 G, and the diameter of the annular groove 22.1 is 5~20 mm.

[0033] In one specific embodiment, the cone angle of the insulating truncated cone 31.1 and the conductor truncated cone 32.1 is 15~75°, and the cone angle is the angle of the cone tip. In this embodiment of the invention, the insulating truncated cone 31.1 and the conductor truncated cone 32.1 do not have actual cone tips. Their sidewalls can be extended and converged at a point, and the angle of this point is the cone angle.

[0034] In one specific embodiment, the height of the conductor truncated cone 32.1 is 20~60 mm, and the height of the insulating truncated cone 31.1 is 100~200 mm.

[0035] The electrospinning apparatus provided in the embodiments of the present invention, such as Figure 2 As shown, the outer casing 1 includes a handheld part 11 and a spinning part 12 connected to each other. The overall shape of the outer casing 1 resembles a pistol, with the handheld part 11 being the area of ​​the pistol grip and the spinning part 12 being the area of ​​the pistol body. The injection mechanism 4 is located inside the spinning part 12. The power supply mechanism 5 includes a battery 51, a high-voltage power generator 52, and a voltage control module 53. The battery 51 is located inside the handheld part 11, and the battery 51 is preferably a lithium battery 51. The battery 51 is connected to the high-voltage power generator 52. The high-voltage power generator 52 and the voltage control module 53 are located inside the spinning part 12. The high-voltage power generator 52 is connected to the injection tube assembly 2, usually via a wire. The battery 51 serves as the power source, the high-voltage power generator 52 boosts the voltage provided by the battery 51, and the voltage control module 53 regulates the voltage output by the high-voltage power generator 52.

[0036] In one specific embodiment, such as Figure 1 and Figure 2 As shown, a knob 13 is provided on the outer wall of the outer casing 1. The knob 13 is preferably located on the handheld part 11 and is connected to the voltage control module 53. The knob 13 can generally be set with 2 to 5 levels to achieve voltage adjustment in 2 to 5 levels. Adjusting the voltage can adjust the fiber size and simultaneously affect the stability of the spinning process. Furthermore, different spinning solutions may require different spinning voltages.

[0037] In one specific embodiment, such as Figure 1 and Figure 2 As shown, a trigger 15 is provided on the outer side wall of the outer casing 1. The trigger 15 is connected to the drive component 42 and is used to control the injection speed of the drive component 42.

[0038] In an improved embodiment, such as Figure 1 As shown, a flexible solar panel 14 is provided on the outer wall of the outer casing 1, and the flexible solar panel 14 is connected to the high-voltage power generator 52. The flexible solar panel 14 can replace the battery 51 as a power source, or it can be used together with the battery 51 as a power source, or it can be used to charge the battery 51.

[0039] The present invention also provides a method for using an electrospinning device for outdoor in-situ deposited fiber dressings, comprising the following steps: Step 1) Align the electrospinning device with the wound, and drive 42 pushes the injection fluid in the storage chamber 41 into the injection tube assembly 2.

[0040] Step 2) The injection tube assembly 2 fiberizes the flowing injection fluid and then sprays it out from the needle 6.

[0041] During the injection process, the knob 13 can be rotated and the trigger 15 can be pulled to adjust the voltage level and control the injection speed.

[0042] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present invention, and these improvements and substitutions should also be considered within the scope of protection of the present invention.

Claims

1. An electrospinning device for in-situ deposited fiber dressings for outdoor use, characterized in that: It includes an outer shell (1), a spray pipe assembly (2), and a directional safety cover (3); the inner part of the outer shell (1) is provided with a push mechanism (4) and a power supply mechanism (5), the push mechanism (4) includes a liquid storage chamber (41) and a drive component (42); the power supply mechanism (5) serves as a power source; The inlet end of the injection tube assembly (2) is located inside the outer shell (1) and connected to the liquid storage chamber (41), while the outlet end of the injection tube assembly (2) is located outside the outer shell (1). The side wall of the injection tube assembly (2) is connected to the power supply mechanism (5), and a conductive sheet (23) is provided in the side wall of the injection tube assembly (2) located outside the outer shell (1). The outlet end of the injection tube (21) is detachably provided with a needle (6). The directional safety cover (3) is located on the side wall of the outer shell (1). The directional safety cover (3) includes an insulating cover (31) and a conductor cover (32) located inside the insulating cover (31). The injection tube assembly (2) is located inside the conductor cover (32), and the conductive sheet (23) is in contact with the conductor cover (32).

2. The electrospinning apparatus according to claim 1, characterized in that: The injection tube assembly (2) includes an injection tube (21) and an annular component (22). The inlet end of the injection tube (21) is located inside the outer shell (1) and connected to the liquid storage chamber (41). The outlet end of the injection tube (21) is located outside the outer shell (1). The annular component (22) is arranged around the outer wall of the injection tube (21) located outside the outer shell (1). The outer wall of the annular component (22) is provided with an annular groove (22.1). The conductive sheet (23) is disposed in the annular groove (22.1).

3. The electrospinning apparatus according to claim 2, characterized in that: The inner diameter of the injection tube (21) is 0.5~1.5 mm, the specification of the needle (6) is 17~25G, and the diameter of the annular groove (22.1) is 5~20 mm.

4. The electrospinning apparatus according to claim 1, characterized in that: The insulating cover (31) includes an insulating truncated cone (31.1) and an insulating column (31.2) connected to each other, and the conductor cover (32) includes a conductor truncated cone (32.1) and a conductor column (32.2) connected to each other; the conductor column (32.2) is in contact with the outer wall of the injection pipe assembly (2), the insulating column (31.2) is in contact with the conductor column (32.2), and the insulating truncated cone (31.1) is in contact with the conductor truncated cone (32.1); the cone tips of the conductor truncated cone (32.1) and the insulating truncated cone (31.1) face the outer shell (1).

5. The electrospinning apparatus according to claim 5, characterized in that: The cone angles of the insulating truncated cone (31.1) and the conductor truncated cone (32.1) are 15~75°.

6. The electrospinning apparatus according to claim 5, characterized in that: The height of the conductor truncated cone (32.1) is 20~60 mm, and the height of the insulating truncated cone (31.1) is 100~200 mm.

7. The electrospinning apparatus according to claim 2, characterized in that: The insulating cover (31) is made of polymer material, the conductor cover (32) is made of metal, the injection tube (21) is made of metal, and the needle (6) is made of metal.

8. The electrospinning apparatus according to claim 1, characterized in that: The outer casing (1) includes a handheld part (11) and a spinning part (12) connected together. The injection mechanism (4) is located inside the spinning part (12). The power supply mechanism (5) includes a battery (51), a high-voltage power generator (52), and a voltage control module (53). The battery (51) is located inside the handheld part (11). The high-voltage power generator (52) and the voltage control module (53) are located inside the spinning part (12). The high-voltage power generator (52) is connected to the injection tube assembly (2). The battery (51) serves as the power source. The voltage control module (53) is used to adjust the voltage of the high-voltage power generator (52).

9. The electrospinning apparatus according to claim 8, characterized in that: A knob (13) is provided on the outer wall of the outer casing (1), and the knob (13) is connected to the voltage control module (53); and / or, a flexible solar panel (14) is provided on the outer wall of the outer casing (1), and the flexible solar panel (14) is connected to the high voltage power generator (52); and / or, a trigger (15) is provided on the outer wall of the outer casing (1), and the trigger (15) is connected to the drive unit (42).

10. The method of using the electrospinning apparatus according to any one of claims 1 to 9, characterized in that, It includes the following steps: Step 1) Align the electrospinning device with the wound, and the drive unit (42) pushes the injection fluid in the storage chamber (41) into the injection tube assembly (2); Step 2) The injection tube assembly (2) fibroses the flowing injection fluid and then sprays it out from the needle (6).

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