Multi-target slow-release whitening cosmetic composition and preparation method thereof

Abstract

The invention belongs to the technical field of daily chemicals, and particularly relates to a multi-target slow-release whitening cosmetic composition and a preparation method thereof. The multi-target slow-release whitening cosmetic composition is prepared from the following components in parts by weight: 1 to 5 parts of lipidosome, 0.1 to 0.3 part of hydrolyzed algae extract, 0.1 to 0.5 part of plant compound and 94.2 to 98.8 parts of liquid crystal emulsion matrix. According to the invention, an anti-blue-light whitening system is created, and a spectrum absorbent (hydrolyzed algae) and a free radical scavenger (VC / VE) are cooperated to cover a 415-470nm blue light damage wave band; a four-dimensional delivery network and a quick and slow dual-phase release system are created, and time-space precise intervention of a melanin regulation link is realized; and through multi-dimensional evaluation of an ITA value, an MI value and a TEWL value, dual effects of covering whitening and barrier repairing are realized.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical technology, specifically relating to a multi-target sustained-release whitening cosmetic composition and its preparation method. Background Technology

[0002] Traditional skin-whitening agents, due to their molecular structure limitations, are mostly highly polar or have large molecular weights, making it difficult to penetrate the stratum corneum of the skin. Their absorption rate through the scalp is low; data shows that the transdermal absorption of free 377 (phenylethyl resorcinol) is ≤15%, and the actual absorption rate of vitamin C is less than 10%. Furthermore, most skin-whitening agents have poor stability; under high temperature or light conditions, components such as kojic acid and vitamin C are easily deactivated. 377, stored at 60°C for 30 days, experiences a deactivation rate of >40%. Simultaneously, traditional skin-whitening agents also pose irritation and safety risks. Hydroquinone, due to its high irritant properties, easily causes skin irritation and has been banned due to its cytotoxicity. Arbutin carries a phototoxic risk; it decomposes under light, potentially burning the skin or even causing contact dermatitis and skin damage. When the concentration of 377 exceeds 4%, approximately 20% of people experience redness, swelling, and peeling. Finally, excessive pursuit of whitening and long-term use of high-concentration skin-whitening agents may damage the skin barrier, leading to dryness, sensitivity, and other problems.

[0003] The blue light emitted from electronic screens has a wavelength between 400-500nm, which is more easily overlooked compared to the 200-400nm ultraviolet light. Blue light has a longer wavelength and lower energy, allowing it to penetrate deeper into the skin, reaching the dermis and causing pigmentation and hyperpigmentation, leading to age spots. A review of current skin whitening product efficacy combinations and formulation technologies reveals that a clear solution has not yet been provided.

[0004] Since melanin formation involves four stages—induction, synthesis, transport, and shedding—a single whitening mechanism cannot cover the entire chain, resulting in traditional whitening products having a low effect on improving the skin's melanin index (MI). Summary of the Invention

[0005] To address the shortcomings of the existing technology, this invention provides a multi-target sustained-release whitening cosmetic composition and its preparation method.

[0006] The specific technical solution is as follows: The first objective of this invention is to provide a multi-target sustained-release whitening cosmetic composition, comprising, by weight, the following components: 1-5 parts liposomes, 0.1-0.3 parts hydrolyzed algae extract, 0.1-0.5 parts plant compound, and 94.2-98.8 parts liquid crystal emulsion matrix.

[0007] Furthermore, by weight, the liposomes comprise 75.9 parts of liposome phase A and 24.1 parts of liposome phase B. Liposome phase A comprises 68.9 parts of solvent and 7 parts of moisturizer, while liposome phase B comprises 10 parts of whitening agent, 6 parts of emulsifier, 5 parts of emollient, 3 parts of antioxidant and 0.1 parts of moisturizer.

[0008] Furthermore, in the liposome B phase, the whitening agent includes phenylethyl resorcinol 377, the emulsifier includes polyglycerol-10 myristate and lecithin, the emollient includes caprylic / capric triglyceride, the antioxidant includes tocopheryl acetate, and the moisturizer includes caprylyl glycol.

[0009] Furthermore, in the liposome A phase, the solvent includes water, and the humectant includes 1,2-hexanediol, butanediol, and glycerol.

[0010] Furthermore, the hydrolyzed algae extract includes an enzymatically hydrolyzed extract of Euglena spp. powder.

[0011] Furthermore, by weight, the plant compound comprises 35 parts of licorice root, 15 parts of jujube fruit, 25 parts of artemisia capillaris flower, and 25 parts of bamboo leaves.

[0012] Further, by weight, the liquid crystal emulsion matrix comprises 13.7 parts of liquid crystal emulsion matrix A phase, 85.3 parts of liquid crystal emulsion matrix B phase, 0.9 parts of liquid crystal emulsion matrix C phase, and 0.1 parts of liquid crystal emulsion matrix D phase. The liquid crystal emulsion matrix A phase comprises 2.9 parts of emulsifier, 8.8 parts of emollient, 1.5 parts of co-emulsifier, and 0.5 parts of antioxidant. The liquid crystal emulsion matrix B phase comprises 75.71 parts of solvent, 7.12 parts of moisturizer, 2.12 parts of skin conditioning agent, and 0.35 parts of thickener. The liquid crystal emulsion matrix C phase comprises 0.3 parts of skin conditioning agent, 0.25 parts of antioxidant, and 0.25 parts of preservative. The liquid crystal emulsion matrix D phase comprises 0.1 parts of fragrance.

[0013] Furthermore, in the liquid crystal emulsion matrix A phase, the emulsifiers include polyglycerol-6 distearate and polyglycerol-3 beeswax ester, the emollients include jojoba esters, C10-18 fatty acid triglycerides, shea butter (BUTYROSPERMUM PARKII), polydimethylsiloxane, and jojoba seed oil (SIMMONDSIA CHINENSIS), the co-emulsifier includes cetearyl alcohol, and the antioxidant includes tocopheryl acetate.

[0014] Furthermore, in the liquid crystal emulsion matrix B phase, the solvent includes water, the moisturizer includes glycerin, butylene glycol and sodium hyaluronate, the skin conditioning agent includes niacinamide and allantoin, and the thickener includes ammonium acryloyldimethyl taurate / VP copolymer.

[0015] Furthermore, in the liquid crystal emulsion matrix C phase, the skin conditioning agent includes bisabolol and 3-o-ethyl ascorbic acid, the antioxidant includes p-hydroxyacetophenone, and the preservative includes phenoxyethanol.

[0016] Furthermore, in the liquid crystal emulsion matrix D phase, the fragrance agent includes a flavoring.

[0017] The second objective of this invention is to provide a method for preparing the above-mentioned multi-target sustained-release whitening cosmetic composition, comprising the following steps: preparing liposomes, hydrolyzed algae extract, plant compound and liquid crystal emulsion matrix respectively; adding the prepared liposomes, hydrolyzed algae extract and plant compound to the liquid crystal emulsion matrix in sequence according to the formula amount; stirring evenly to obtain Zhenbai Repairing Cream, that is, the multi-target sustained-release whitening cosmetic composition.

[0018] Furthermore, the preparation method of the liposomes includes the following steps: weigh liposome phase A and liposome phase B according to the ratio, slowly add phase B to phase A, stir at room temperature for 25 min, then pre-homogenize with a high-speed homogenizer for 5 min at a speed of 12000 rpm, and finally process with a high-pressure homogenizer at 50 MPa and 100 MPa once, and at 150 MPa three times, with the process temperature controlled below 42℃, to obtain the liposomes.

[0019] Furthermore, the preparation method of the hydrolyzed algae extract includes the following steps: preferentially selecting Euglena spp. powder, after cell wall breaking treatment, soaking in 5 times the amount of water, adding hydrochloric acid to adjust the pH to 7-7.5, adding 0.5% compound enzyme, 0.5% cellulase, and 0.2 M sodium chloride, fermenting at a constant temperature of 35℃ for 48 hours, filtering the fermentation broth to remove impurities, filtering again, concentrating, and spray drying to obtain the hydrolyzed algae extract, namely, the enzymatic hydrolysis extract of Euglena spp. powder.

[0020] Furthermore, the preparation method of the plant compound includes the following steps: weigh each component according to the proportion, wash, dry, pulverize, add 6 times 40% ethanol, heat under reflux for 1 hour, extract 3 times, combine the filtrates, and reduce to a thick paste using a rotary evaporator to obtain the plant compound.

[0021] Furthermore, the preparation method of the liquid crystal emulsion matrix includes the following steps: weigh liquid crystal emulsion matrix A phase and liquid crystal emulsion matrix B phase according to the ratio, heat to 75°C, keep warm and stir until completely uniform, slowly add liquid crystal emulsion matrix A phase to liquid crystal emulsion matrix B phase, pre-homogenize with a high-speed homogenizer for 5 min, set the speed to 8000 rpm, after homogenization, keep the sample at 75°C and stir for 25 min, cool down to 45°C, add liquid crystal emulsion matrix C phase and liquid crystal emulsion matrix D phase, stir evenly, and the liquid crystal emulsion matrix is ​​obtained.

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) Quadruple whitening + anti-blue light technology architecture: This invention provides an in-depth analysis of the human skin color regulation system. Through a multi-target sustained-release design that reduces melanin induction, decreases melanin synthesis, disrupts melanin transport, and promotes melanin shedding, it covers the entire process of melanin production. 1) Source Inhibition Layer: Blue light protection + dual antioxidants effectively reduce melanin production at the source. Melanin production begins with nitric oxide free radicals generated after ultraviolet irradiation. The anti-blue light repair factor, hydrolyzed algae extract, has an absorption spectrum with a maximum value at 455 nm, which is effectively lower than blue light irradiation, reducing melanin induction. The dual antioxidants, vitamin C derivative (3-o-ethyl ascorbic acid) and vitamin E derivative (tocopheryl acetate), effectively reduce the generation of free radicals and can eliminate existing free radicals. Thus, this invention establishes an anti-blue light whitening system that synergistically combines a spectral absorber (hydrolyzed algae) with a free radical scavenger (VC / VE) to cover the 415-470nm blue light damage band. 2) Synthesis blocking layer: The addition of compound herbal essence, rich in plant extracts such as licorice root and bamboo leaf, all of which inhibit tyrosinase and melanin synthesis, and have a synergistic effect; at the same time, it is combined with the whitening and spot-removing ingredient phenylethyl resorcinol 377, which uses liposome encapsulation technology to achieve targeted delivery and high concentration retention, which is conducive to sustained release and controlled release, prolonging the time of action and improving the whitening effect; 3) Transport Interference Layer: Niacinamide combined with Artemisia capillaris can downregulate the transport of melanosomes from melanocytes to keratinocytes without inhibiting tyrosinase activity or cell proliferation, thus affecting skin pigmentation. It can also interfere with the cell signaling channels between keratinocytes and melanocytes, reducing melanin production. 4) Metabolic Accelerator Layer: Niacinamide combined with jujube fruit extract can accelerate the metabolism of the skin's stratum corneum and promote the timely excretion of keratinocytes containing melanin. Experiments have shown that after applying jujube extract, the number of keratinocytes is significantly reduced, which means that the flattened keratinocytes are excreted from the body at an accelerated rate, indicating that jujube extract can promote the shedding of melanocytes.

[0023] (2) Innovative delivery and sustained-release systems: This invention creates a four-dimensional delivery network and a fast-slow dual-phase release system, achieving precise spatiotemporal intervention in the melanin regulation pathway: 1) Liquid crystal emulsion matrix: Combined with polyglycerol-6 distearate and polyglycerol-3 beeswax ester, the typical layered liquid crystal structure formed can further simulate the human stratum corneum and provide the protection of a "second skin"; compared with traditional emulsion products, liquid crystal emulsion products have significant advantages in terms of stability, water retention and moisturizing properties, slow release, penetration promotion and performance. 2) Biphasic sustained-release system: Fast-release phase: free nicotinamide (release rate >70% in 2h); Sustained-release phase: liposome 377 (continuous release in 24h, retention increased by 121.7%).

[0024] (3) Whitening and Repairing Efficacy System: This invention achieves dual effects of whitening and barrier repair through multi-dimensional evaluation of ITA° value, MI value, and TEWL value. Attached Figure Description

[0025] Figure 1 This is a graph showing the cumulative transdermal absorption rate in Test 1 of this invention. Figure 2 This is a graph showing the retention rate in Test 1 of the present invention; Figure 3 These are photographs taken on the 6th day after different samples collected in Test 2 of this invention were applied to the melanin model. Figure 4 These are the HE staining results of different samples collected in Test 2 of this invention on day 6 after being applied to the melanin model; Figure 5 This is a graph showing the melanin content results of different samples collected in Test 2 of this invention after being applied to the melanin model; Figure 6 These are facial images collected before and after use in Test 3 of this invention; Figure 7 This is a graph showing the results of the skin ITA° difference test in 4 tests according to the present invention; Figure 8 This is a graph showing the results of the skin MI difference in test 4 of this invention; Figure 9 The figure shows the results of the transdermal water loss (TEWL) test in Test 4 of this invention. Detailed Implementation

[0026] The principles and features of the present invention are described below with reference to examples. The examples are only used to explain the present invention and are not intended to limit the scope of the present invention. The parts mentioned in the specific embodiments are parts by weight.

[0027] Example 1 A multi-target sustained-release whitening cosmetic composition, comprising, by weight, the following components: 1 part liposomes, 0.1 part hydrolyzed algae extract, 0.2 parts plant compound, and 98.7 parts liquid crystal emulsion matrix; The composition and proportions of each component are shown in Tables 1-3 below: Table 1. Composition and proportions of liposomes

[0028] Table 2 Composition and Proportion of Plant-Based Compound Formulas

[0029] Table 3 Composition and proportions of liquid crystal emulsion matrix

[0030] A method for preparing a multi-target sustained-release whitening cosmetic composition includes the following steps: Preparation of liposomes: The preparation method includes the following steps: Liposome phase A and liposome phase B are weighed according to the ratio. Phase B is slowly added to phase A and stirred at room temperature for 25 min. Then, it is pre-homogenized with a high-speed homogenizer for 5 min at a speed of 12000 rpm. Finally, it is treated once with a high-pressure homogenizer at 50 MPa and 100 MPa, and three times with 150 MPa. The process temperature is controlled below 42℃ to obtain the liposomes. Preparation of hydrolyzed algal extract: The preparation method includes the following steps: Euglena spp. powder is preferentially selected, and after cell wall breaking treatment, it is soaked in 5 times the amount of water. Hydrochloric acid is added to adjust the pH to 7.0. 0.5% compound enzyme (0.3% pectinase Merck P2611, 0.2% papain Merck 1.07149), 0.5% cellulase (Merck C2605), and 0.2 M sodium chloride are added. Fermentation is carried out at a constant temperature of 35℃ for 48 hours. The fermentation broth is filtered, impurities are removed, filtered again, concentrated, and spray-dried to obtain the hydrolyzed algal extract, namely, the enzymatic hydrolysis extract of Euglena spp. powder. Preparation of plant compound: The preparation method includes the following steps: weigh each component according to the proportion, wash, dry, pulverize, add 6 times 40% ethanol, heat under reflux for 1 hour, extract 3 times, combine the filtrates, and reduce to a thick paste using a rotary evaporator to obtain the plant compound. Preparation of liquid crystal emulsion matrix: The preparation method includes the following steps: Weigh liquid crystal emulsion matrix A phase and liquid crystal emulsion matrix B phase according to the ratio, heat to 75℃, keep warm and stir until completely homogeneous, slowly add liquid crystal emulsion matrix A phase to liquid crystal emulsion matrix B phase, pre-homogenize with a high-speed homogenizer for 5 min, the speed is set to 8000 rpm, after homogenization the sample is kept warm and stirred at 75℃ for 25 min, after cooling to 45℃, add liquid crystal emulsion matrix C phase and liquid crystal emulsion matrix D phase, stir evenly, and the liquid crystal emulsion matrix is ​​obtained; The prepared liposomes, hydrolyzed algae extract and plant compound were added to the liquid crystal emulsion matrix in sequence according to the formula amount, and stirred evenly to obtain Zhenbai Repairing Cream, which is the multi-target sustained-release whitening cosmetic composition.

[0031] Example 2 A multi-target sustained-release whitening cosmetic composition comprises, by weight, the following components: 2 parts liposomes, 0.2 parts hydrolyzed algae extract, 0.1 parts plant compound, and 97.7 parts liquid crystal emulsion matrix. The remaining technical features are as described in Example 1.

[0032] Example 3 A multi-target sustained-release whitening cosmetic composition comprises, by weight, the following components: 3 parts liposomes, 0.1 parts hydrolyzed algae extract, 0.1 parts plant compound, and 96.8 parts liquid crystal emulsion matrix. The remaining technical features are as described in Example 1.

[0033] Comparative Example A whitening cosmetic composition, referring to Example 1, differs from Example 1 in that it does not use liposomes, hydrolyzed algae extracts and plant compounds, but only uses 100 parts of liquid crystal emulsion matrix.

[0034] test: 1. Using a vertical Franz diffusion cell and fresh pig skin (simulating human skin), the transdermal absorption and retention of free phenylethyl resorcinol, encapsulated phenylethyl resorcinol, and the Zhenbai Repairing Cream prepared in Example 1 were tested. The results are as follows: Figure 1 and Figure 2 As shown.

[0035] Figure 1 and Figure 2 Data shows that, compared with free phenylethyl resorcinol, the encapsulated phenylethyl resorcinol has a 44.8% increase in penetration and a 121.7% increase in retention. Compared with encapsulated phenylethyl resorcinol, the Zhenbai Repair Cream prepared using the liquid crystal emulsification technology of Example 1 has a further increase in penetration and retention, by 12.7% and 31.1% respectively, demonstrating superior permeability and retention.

[0036] 2. Using a 3D reconstructed epidermal melanin model as a testing tool, the samples from each embodiment and comparative example were stimulated by surface application. The influence of the sample on melanin formation was evaluated through key indicators such as appearance, melanin distribution, and quantitative melanin content, thereby indirectly evaluating the whitening efficacy of the sample. The samples in Examples 1-3 are referred to as Samples 1-3, and the sample in the comparative example is Sample 4.

[0037] The experiment was divided into three groups: Control group, UVB group, and UVB+ sample group. The group descriptions are as follows: (1) Control group: Sample 4 of the control group was given the drug without any treatment conditions; (2) UVB group: The melanin model was irradiated with UVB every day; (3) UVB+ sample group: The melanin model was irradiated with UVB every day and given the drug (samples 1-3 were given the drug respectively).

[0038] UVB+ sample group: UVB irradiation (50 mJ / cm²) began 0 days after the model was manufactured. 2 The control group received UVB stimulation for a certain period of time each day for 3 consecutive days. Afterward, cream samples 1, 2, and 3 were added to treat the melanin model. Samples were taken and photographed on day 6. The UVB group received UVB irradiation (50 mJ / cm²) starting 0 days after model delivery. 2 ), perform UVB stimulation for a certain period of time each day for 3 consecutive days, and take samples and photographs on day 6 for observation; if Figure 3 As shown.

[0039] Figure 3 The results showed that the UVB irradiated group model had more melanin deposition, while the surface melanin deposition of the sample 1, 2, 3 and Control (sample 4) treatment group models was significantly reduced compared with the UVB irradiated group.

[0040] Samples were taken at 6 days for HE staining and observation; results are shown below. Figure 4 .

[0041] Figure 4 The results showed that the histological structures of the Control (sample 4) group, the UVB irradiation group, and the sample (1-3) treatment group all exhibited a multilayered structure consisting of the basal layer, granular layer, spinous layer, and stratum corneum, similar to the structure of normal human skin tissue. Normal HE results indicate that surface drug administration did not affect the normal structural development of the model. Therefore, the changes in apparent melanin in the model are a direct result of the whitening effect of the active ingredient.

[0042] Samples were taken at 0, 3, and 6 days. Melanin in the model was extracted using the NaOH method, and its OD value was measured. Quantification was performed using a standard curve. After data processing, the results were plotted and analyzed. The results are shown in [Figure number missing]. Figure 5 .

[0043] Figure 5The results show that the melanin content of the treated groups of samples 1, 2, and 3 is lower than that of the UVB irradiated group, indicating that samples 1-3 of this application embodiment are effective; the melanin content of the treated groups of samples 1 and 3 is slightly higher than that of the Control group, and the melanin content of the treated group of sample 2 is lower than that of the Control group, indicating that the ability of samples 1-3 of this application embodiment to reduce melanin after UVB irradiation is comparable to that of the comparative example sample 4 without UVB irradiation.

[0044] 3. Volunteers were selected to use the Zhenbai Repairing Cream prepared in Example 2 continuously for 28 days. Facial images before and after use were collected using an intelligent skin image analysis skin detector. The results are analyzed below. Figure 6 .

[0045] Depend on Figure 6 The results show that after 28 days of using the product prepared in Example 2, the proportion of epidermal pigmentation in Volunteer 1 decreased from 15.20% to 12.6%, with an improvement rate of 17.1%; the proportion of epidermal pigmentation in Volunteer 2 decreased from 19.40% to 13.2%, with an improvement rate of 32%; and the proportion of epidermal pigmentation in Volunteer 3 decreased from 15.60% to 12.50%, with an improvement rate of 19.87%. This demonstrates that the present invention has a very good effect on removing pigmentation and whitening the skin.

[0046] 4. Human efficacy testing (Chapter 8, Human Efficacy Evaluation and Testing Methods, Section 5, Whitening and Spot-Removing Efficacy Testing Method 1: Ultraviolet-Induced Human Skin Melanization Model Whitening and Spot-Removing Efficacy Test) of the Zhenbai Repairing Cream prepared in Example 2 was conducted at weeks 1, 2, 3, and 4. The results are as follows: Figures 7-9 As shown.

[0047] Depend on Figure 7 and Figure 8 The results showed that the ITA° difference of the product of Example 2 of the present invention was significantly improved (p<0.05) in the 4th week compared with the negative control (i.e., blank control group: no sample applied), with an effect improvement of about 27.4%; the MI difference was also significantly improved (p<0.05) compared with the negative control (i.e., blank control group: no sample applied), with an effect improvement of 16.6%; thus, it is shown that the test product of the present invention has the effect of removing spots and whitening.

[0048] Based on the human efficacy evaluation test—repair efficacy, the efficacy assessment index is transdermal water loss (TEWL); the smaller the TEWL value, the slower the transdermal water loss. Figure 9 The results showed that after using the Zhenbai Repairing Cream of Example 2 of the present invention for 2 weeks, the transepidermal water loss (TEWL) value was significantly improved, with a reduction rate of about 30.0%, indicating that the product of the present invention has the effect of repairing the skin barrier function.

[0049] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A multi-target sustained-release whitening cosmetic composition, characterized in that, By weight, it comprises the following components: 1-5 parts liposomes, 0.1-0.3 parts hydrolyzed algal extract, 0.1-0.5 parts plant compound, and 94.2-98.8 parts liquid crystal emulsion matrix.

2. The multi-target sustained-release whitening cosmetic composition according to claim 1, characterized in that, By weight, the liposomes comprise 75.9 parts of liposome phase A and 24.1 parts of liposome phase B. Liposome phase A comprises 68.9 parts of solvent and 7 parts of moisturizer, while liposome phase B comprises 10 parts of whitening agent, 6 parts of emulsifier, 5 parts of skin moisturizer, 3 parts of antioxidant and 0.1 parts of moisturizer.

3. The multi-target sustained-release whitening cosmetic composition according to claim 2, characterized in that, In the liposome B phase, the whitening agent includes phenylethyl resorcinol 377, the emulsifier includes polyglycerol-10 myristate and lecithin, the emollient includes caprylic / capric triglyceride, the antioxidant includes tocopheryl acetate, and the moisturizer includes caprylyl glycol.

4. The multi-target sustained-release whitening cosmetic composition according to claim 2, characterized in that, In the liposome phase A, the solvent includes water, and the humectant includes 1,2-hexanediol, butylene glycol, and glycerin.

5. The multi-target sustained-release whitening cosmetic composition according to claim 1, characterized in that, The hydrolyzed algae extract includes an enzymatically hydrolyzed extract of Euglena spp. powder.

6. The multi-target sustained-release whitening cosmetic composition according to claim 1, characterized in that, By weight, the plant compound comprises 35 parts of licorice root, 15 parts of jujube fruit, 25 parts of artemisia capillaris flower, and 25 parts of bamboo leaves.

7. The multi-target sustained-release whitening cosmetic composition according to claim 1, characterized in that, By weight, the liquid crystal emulsion matrix comprises 13.7 parts of liquid crystal emulsion matrix A phase, 85.3 parts of liquid crystal emulsion matrix B phase, 0.9 parts of liquid crystal emulsion matrix C phase, and 0.1 parts of liquid crystal emulsion matrix D phase. The liquid crystal emulsion matrix A phase comprises 2.9 parts of emulsifier, 8.8 parts of emollient, 1.5 parts of co-emulsifier, and 0.5 parts of antioxidant. The liquid crystal emulsion matrix B phase comprises 75.71 parts of solvent, 7.12 parts of moisturizer, 2.12 parts of skin conditioning agent, and 0.35 parts of thickener. The liquid crystal emulsion matrix C phase comprises 0.3 parts of skin conditioning agent, 0.25 parts of antioxidant, and 0.25 parts of preservative. The liquid crystal emulsion matrix D phase comprises 0.1 parts of fragrance.

8. The multi-target sustained-release whitening cosmetic composition according to claim 7, characterized in that, In the liquid crystal emulsion matrix A phase, the emulsifiers include polyglycerol-6 distearate and polyglycerol-3 beeswax ester, the emollients include jojoba esters, C10-18 fatty acid triglycerides, shea butter (BUTYROSPERMUM PARKII), polydimethylsiloxane, and jojoba seed oil (SIMMONDSIA CHINENSIS), the co-emulsifier includes cetearyl alcohol, and the antioxidant includes tocopheryl acetate. In the liquid crystal emulsion matrix B phase, the solvent includes water, the moisturizer includes glycerin, butylene glycol and sodium hyaluronate, the skin conditioning agent includes niacinamide and allantoin, and the thickener includes ammonium acryloyl dimethyl taurate / VP copolymer; In the liquid crystal emulsion matrix C phase, the skin conditioning agent includes bisabolol and 3-o-ethyl ascorbic acid, the antioxidant includes p-hydroxyacetophenone, and the preservative includes phenoxyethanol; In the liquid crystal emulsion matrix D phase, the fragrance agent includes flavoring.

9. A method for preparing a multi-target sustained-release whitening cosmetic composition as described in any one of claims 1 to 8, characterized in that, The process includes the following steps: preparing liposomes, hydrolyzed algae extract, plant compound, and liquid crystal emulsion matrix respectively; adding the prepared liposomes, hydrolyzed algae extract, and plant compound to the liquid crystal emulsion matrix in sequence according to the formula amount; stirring evenly to obtain Zhenbai Repairing Cream, which is the multi-target sustained-release whitening cosmetic composition.

10. The method for preparing the multi-target sustained-release whitening cosmetic composition according to claim 9, characterized in that, The preparation method of the liposomes includes the following steps: liposome phase A and liposome phase B are weighed according to the ratio, phase B is slowly added to phase A, stirred at room temperature for 25 min, then pre-homogenized for 5 min at a speed of 12000 rpm, and finally treated once at 50 MPa and 100 MPa, and three times at 150 MPa, with the process temperature controlled below 42℃, to obtain the liposomes; The preparation method of the hydrolyzed algae extract includes the following steps: Select Euglena powder, after cell wall breaking treatment, soak it in 5 times the amount of water, add hydrochloric acid to adjust the pH to 7-7.5, add 0.5% compound enzyme, 0.5% cellulase and 0.2 M sodium chloride, ferment at 35℃ for 48 hours, filter the fermentation liquid to remove impurities, filter again, concentrate and spray dry to obtain the hydrolyzed algae extract; The preparation method of the plant compound includes the following steps: weigh each component according to the proportion, wash, dry, pulverize, add 6 times 40% ethanol, heat under reflux for 1 hour, extract 3 times, combine the filtrates, evaporate and concentrate to a thick paste to obtain the plant compound. The preparation method of the liquid crystal emulsion matrix includes the following steps: weigh liquid crystal emulsion matrix A phase and liquid crystal emulsion matrix B phase according to the ratio, heat to 75°C, keep warm and stir until completely uniform, slowly add liquid crystal emulsion matrix A phase to liquid crystal emulsion matrix B phase, pre-homogenize for 5 min, set the rotation speed to 8000 rpm, after homogenization, keep the sample at 75°C and stir for 25 min, cool down to 45°C, add liquid crystal emulsion matrix C phase and liquid crystal emulsion matrix D phase, stir evenly, and the liquid crystal emulsion matrix is ​​obtained.

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