Multi-channel sampling system and method for online analyzer

Abstract

The multi-channel sampling system comprises a multi-channel injection pump, the multi-channel injection pump is provided with a first channel, a second channel, a third channel, a fourth channel, a fifth channel, a sixth channel, a seventh channel, an eighth channel and a ninth channel, the first channel is connected with a three-way connecting pipe through a second waste discharge pipe, and the second waste discharge pipe is connected with a second waste discharge pipe. The third channel is communicated with a first analysis cup through a first injection pipe, the fourth channel is communicated with a second analysis cup through a second injection pipe, and the fifth channel is communicated with a third analysis cup through a third injection pipe; according to the multi-channel injection pump disclosed by the invention, the multi-item analysis sampling requirement is met by one multi-channel injection pump, the sampling element is simplified, and the adaptability of an analysis machine table to liquid medicines with different concentrations is improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical liquid sampling and detection technology, and to a multi-channel sampling system and method for online analyzers. Background Technology

[0002] An online analyzer is a device that monitors and analyzes chemical components and other parameters in a process in real time. This device collects samples and analyzes them using chemical analysis techniques, obtaining results in real time. Online analyzers can monitor various water quality parameters, such as pH, dissolved oxygen content, and chemical oxygen demand, which is of great significance for real-time water quality monitoring and control. They can also monitor various parameters in chemical processes, including temperature, pressure, and flow rate, playing a crucial role in improving production quality, refining manufacturing processes, and reducing product loss.

[0003] Currently, the sampling methods of online analyzers can be roughly divided into the following four categories: The first category uses a six-way valve in conjunction with a sampling pump to achieve the sampling purpose; the second category uses multiple sets of three-way valves and sampling pumps in cooperation to achieve the sampling purpose. The disadvantages of the first and second categories are that the sampling volume is fixed and all analytical items share the same sampling volume, resulting in poor instrument compatibility; the third category is based on the second category and uses a modular approach, with one set of sampling modules for each analytical item to achieve the effect of synchronous sampling and analysis. Although the sampling volume can be adjusted according to each item, changing the sampling volume requires changing the capacity of the sampling tube, which is cumbersome; the fourth category uses a three-channel syringe pump or similar components to achieve a variable sampling effect. This method is inefficient and has a long analysis cycle. Summary of the Invention

[0004] Purpose of the invention: The purpose of this invention is to overcome the shortcomings of the prior art and provide a multi-channel sampling system and method for online analyzers.

[0005] Technical Solution: The present invention provides a multi-channel sampling system for an online analyzer, characterized in that it includes a multi-channel injection pump, which is provided with a first channel, a second channel, a third channel, a fourth channel, a fifth channel, a sixth channel, a seventh channel, an eighth channel, and a ninth channel. The first channel is connected to a three-way connector via a second waste discharge pipe, the seventh channel is connected to a three-way connector via a first waste discharge pipe, and the three-way connector is connected to a wastewater tank. The second channel is connected to a liquid collection tank via a chemical pipe, and the liquid collection tank is connected to a tank liquid pipe. The third channel is connected to a first analysis cup via a first injection pipe, the fourth channel is connected to a second analysis cup via a second injection pipe, the fifth channel is connected to a third analysis cup via a third injection pipe, and the sixth channel is connected to a pure water tank via a pure water pipe.

[0006] A further improvement of the present invention is that the liquid collection tank is a sampling cup.

[0007] A further improvement of the present invention is that the liquid collection tank is a flow container.

[0008] A further improvement of the present invention is that the first analytical cup is used to detect the sulfuric acid content in the etching solution.

[0009] A further improvement of the present invention is that the second analytical cup is used to detect the hydrogen peroxide content in the etching solution.

[0010] A further improvement of the present invention is that the third analytical cup is used to detect the copper ion content in the etching solution.

[0011] A further improvement of the present invention is that the 8th channel is connected to the fourth analysis cup and the 9th channel is connected to the fifth analysis cup.

[0012] A multi-channel sampling method for an online analyzer includes the following steps: Step S1: Flushing the tubing with a multi-channel syringe pump; Step S1 includes the following sub-steps: Step S1-1: Switch the multi-channel injection pump to the second channel, so that the piston in the second channel performs an injection action; Step S1-2: Switch the multi-channel injection pump to the first channel, so that the piston in the first channel performs a discharge action; Steps S1-3: Switch the multi-channel injection pump to the second channel again, so that the piston in the second channel performs an injection action; Steps S1-4: Switch the multi-channel injection pump to channel 1 again, so that the piston in channel 1 performs the discharge action. Step S2: Based on the required volume of the first analytical cup, switch the multi-channel syringe pump to the second channel, so that the piston of the second channel performs an injection action. Step S3: Switch the multi-channel syringe pump to the third channel, causing the piston in the third channel to perform a discharge action, and quantitatively inject the sample solution into the first analytical cup; Step S4: Based on the required volume of the second analytical cup, switch the multi-channel syringe pump to the second channel, so that the piston of the second channel performs an injection action. Step S5: Switch the multi-channel syringe pump to channel 4, causing the piston in channel 4 to perform a discharge action, and quantitatively inject the sample solution into the second analytical cup. Step S6: Based on the required volume of the third analytical cup, switch the multi-channel syringe pump to the second channel, so that the piston in the second channel performs an injection action. Step S7: Switch the multi-channel syringe pump to channel 5, causing the piston in channel 5 to discharge, and quantitatively inject the sample solution into the third analytical cup. Step S8: Clean the tubing using a multi-channel syringe pump; Step S8 includes the following sub-steps: Step S8-1: Switch the multi-channel injection pump to the 6th channel, so that the piston in the 6th channel performs an injection action; Step S8-2: Switch the multi-channel injection pump to the 7th channel, so that the piston in the 7th channel performs a discharge action; Step S8-3: Switch the multi-channel injection pump to channel 6 again, so that the piston in channel 6 performs an injection action. Step S8-4: Switch the multi-channel injection pump to channel 7 again, so that the piston in channel 7 performs the discharge action; Step S9: Switch the multi-channel syringe pump to the 6th channel, so that the piston in the 6th channel performs an infeed action to extract pure water. Step S10: Switch the multi-channel syringe pump to channel 5, and make the piston of channel 5 perform a discharge action to flush the residual sample liquid in the pipeline with pure water to the third analytical cup. Step S11: Switch the multi-channel syringe pump to the 6th channel, so that the piston in the 6th channel performs an infeed action to extract pure water. Step S12: Switch the multi-channel syringe pump to the 4th channel, so that the piston of the 4th channel can perform a discharge action, and flush the residual sample liquid in the pipeline with pure water to the second analytical cup. Step S11: Switch the multi-channel syringe pump to the 6th channel, so that the piston in the 6th channel performs an infeed action to extract pure water. Step S13: Switch the multi-channel syringe pump to the third channel, causing the piston in the third channel to discharge, and flush the residual sample solution in the pipeline with pure water to the first analytical cup.

[0013] Compared with the prior art, the multi-channel sampling system and method for online analyzers provided by the present invention achieves at least the following beneficial effects: After fresh medication is injected into the sampling tank of this invention, the multi-channel injection pump can sequentially and quantitatively inject the medication into the first, second, and third analytical cups, completing sampling for three analytical items in a short time. This achieves variable and quantifiable sampling, precise quantitative sampling, and the sampling volume can be adjusted as needed. When the target concentration of the measured medication changes, the sampling volume can be flexibly changed, improving the adaptability of the instrument. A single multi-channel injection pump can meet the sampling needs of multiple analytical items, simplifying sampling components, thereby reducing electrical control components, lowering the complexity of circuits and pipelines, facilitating maintenance, improving the utilization rate of the internal space of the instrument, achieving the effect of sampling for multiple analytical items, and nearly synchronous sampling and analysis of each analytical item. All items can be analyzed in one sampling, saving sampling time and significantly shortening the sampling and overall analysis cycle. The multi-channel injection pump can be reused, increasing the adaptability of the analytical instrument to different concentrations of medication, making it convenient and efficient. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of the present invention.

[0015] In the diagram: 1-Channel 1; 2-Channel 2; 3-Channel 3; 4-Channel 4; 5-Channel 5; 6-Channel 6; 7-Channel 7; 8-Channel 8; 9-Channel 9; 10-Tank liquid pipe; 11-Tank for liquid collection; 12-Drug pipe; A1-First analytical cup; 14-First injection pipe; 15-Second injection pipe; A2-Second analytical cup; 17-Third injection pipe; A3-Third analytical cup; 19-Pure water pipe; 20-Pure water tank; 21-Waste water tank; 22-T-connector; 23-Waste drain pipe 1; 24-Waste drain pipe 2; 25-Multi-channel injection pump. Detailed Implementation

[0016] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that, unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the invention.

[0017] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the invention or its application or use. Techniques, methods, and apparatus known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and apparatus should be considered part of the specification.

[0018] In all the examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values.

[0019] Example 1 like Figure 1 As shown, a multi-channel sampling method for an online analyzer includes the following steps: Step S1: Rinse the tubing using a multi-channel injection pump 25; Step S1 includes the following sub-steps: Step S1-1: Switch the multi-channel injection pump 25 to the second channel 2, so that the piston of the second channel 2 performs an injection action; Step S1-2: Switch the multi-channel injection pump 25 to the first channel 1, so that the piston of the first channel 1 performs a discharge action; Steps S1-3: Switch the multi-channel injection pump 25 to the second channel 2 again, so that the piston of the second channel 2 performs an injection action. Step S1-4: Switch the multi-channel injection pump 25 to the first channel 1 again, so that the piston of the first channel 1 performs the discharge action. Step S2: Based on the required amount of the first analytical cup A1, switch the multi-channel injection pump 25 to the second channel 2, so that the piston of the second channel 2 performs an injection action. Step S3: Switch the multi-channel syringe pump 25 to the third channel 3, so that the piston of the third channel 3 performs a discharge action, and quantitatively inject the sample solution into the first analytical cup A1. Step S4: Based on the required amount of the second analytical cup A2, switch the multi-channel injection pump 25 to the second channel 2, so that the piston of the second channel 2 performs an injection action. Step S5: Switch the multi-channel syringe pump 25 to channel 4, so that the piston of channel 4 performs a discharge action, and quantitatively inject the sample solution into the second analytical cup A2. Step S6: Based on the required amount of the third analytical cup A3, switch the multi-channel injection pump 25 to the second channel 2, so that the piston of the second channel 2 performs an injection action. Step S7: Switch the multi-channel syringe pump 25 to channel 5, so that the piston of channel 5 performs a discharge action, and quantitatively inject the sample solution into the third analytical cup A3. Step S8: Clean the tubing using the multi-channel injection pump 25; Step S8 includes the following sub-steps: Step S8-1: Switch the multi-channel injection pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action; Step S8-2: Switch the multi-channel injection pump 25 to the 7th channel 7, so that the piston of the 7th channel 7 performs a discharge action; Step S8-3: Switch the multi-channel injection pump 25 to the 6th channel 6 again, so that the piston of the 6th channel 6 performs an injection action. Step S8-4: Switch the multi-channel injection pump 25 to the 7th channel 7 again, so that the piston of the 7th channel 7 performs the discharge action. Step S9: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to extract pure water. Step S10: Switch the multi-channel syringe pump 25 to the 5th channel 5, so that the piston of the 5th channel 5 performs a discharge action, and flush the residual sample liquid in the pipeline with pure water to the third analytical cup A3. Step S11: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to extract pure water. Step S12: Switch the multi-channel syringe pump 25 to the 4th channel 4, so that the piston of the 4th channel 4 performs a discharge action, and flush the residual sample liquid in the pipeline with pure water to the second analytical cup A2. Step S11: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to extract pure water. Step S13: Switch the multi-channel syringe pump 25 to the third channel 3, so that the piston of the third channel 3 performs a discharge action, and pure water flushes the residual sample liquid in the pipeline to the first analytical cup A1.

[0020] Example 2 A multi-channel sampling system for an online analyzer, characterized in that it includes a multi-channel injection pump 25, the multi-channel injection pump 25 being provided with a first channel 1, a second channel 2, a third channel 3, a fourth channel 4, a fifth channel 5, a sixth channel 6, a seventh channel 7, an eighth channel 8, and a ninth channel 9; the first channel 1 is connected to a three-way connector 22 via a waste discharge pipe 24; the seventh channel 7 is connected to the three-way connector 22 via a waste discharge pipe 23; the three-way connector 22 is connected to a wastewater tank 21; the second channel 2 is connected to a liquid collection tank 11 via a chemical pipe 12; the liquid collection tank 11 is connected to a tank liquid pipe 10; the third channel 3 is connected to a first analysis cup A1 via a first injection pipe 14; the fourth channel 4 is connected to a second analysis cup A2 via a second injection pipe 15; the fifth channel 5 is connected to a third analysis cup A3 via a third injection pipe 17; and the sixth channel 6 is connected to a pure water tank 20 via a pure water pipe 19.

[0021] The sampling tank 11 is a sampling cup or flow container, which is easy to operate and can quickly complete the sampling. The first analytical cup A1 detects the sulfuric acid content in the etching solution; the second analytical cup A2 detects the hydrogen peroxide content in the etching solution; the third analytical cup A3 detects the copper ion content in the etching solution; the 8th channel 8 is connected to the fourth analytical cup, and the 9th channel 9 is connected to the fifth analytical cup, which can achieve the effect of sampling multiple analytical items.

[0022] The cleaning steps for the multi-channel syringe pump 25 are as follows: Step S14: Clean the sampling and waste discharge pipeline; Step S14 includes the following sub-steps: Step S141: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to pump in pure water. Step S142: Switch the multi-channel injection pump 25 to the 7th channel 7, so that the piston of the 7th channel 7 performs a discharge action to discharge wastewater; Step S143: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to pump in pure water. Step S144: Switch the multi-channel injection pump 25 to the second channel 2, so that the piston of the second channel 2 performs a discharge action to discharge wastewater; Step S145: Switch the multi-channel syringe pump 25 to the 6th channel 6, so that the piston of the 6th channel 6 performs an injection action to pump in pure water. Step S146: Switch the multi-channel injection pump 25 to the first channel 1, so that the piston of the first channel 1 performs a discharge action to discharge wastewater; Step S15: Empty the sampling pipeline; Step S15 includes the following sub-steps: Step S151: Switch the multi-channel syringe pump 25 to the 8th channel 8, so that the piston of the 8th channel 8 performs an infeed action to draw in the sample solution. Step S152: Switch the multi-channel syringe pump 25 to the second channel 2, so that the piston of the second channel 2 performs a discharge action to discharge the sample liquid; Step S16: Drain the pipeline; Step S16 includes the following sub-steps: Step S161: Switch the multi-channel syringe pump 25 to the 8th channel 8, so that the piston of the 8th channel 8 performs an infeed action to draw in the sample solution. Step S162: Switch the multi-channel syringe pump 25 to the 5th channel 5, so that the piston of the 5th channel 5 performs a discharge action to discharge the sample liquid; Step S163: Switch the multi-channel syringe pump 25 to the 8th channel 8, so that the piston of the 8th channel 8 performs an infeed action to draw in the sample solution. Step S164: Switch the multi-channel syringe pump 25 to the 4th channel 4, so that the piston of the 4th channel 4 performs a discharge action to discharge the sample liquid; Step S165: Switch the multi-channel syringe pump 25 to the 8th channel 8, so that the piston of the 8th channel 8 performs an infeed action to draw in the sample solution. Step S166: Switch the multi-channel syringe pump 25 to the third channel 3, so that the piston of the third channel 3 performs a discharge action to discharge the sample liquid.

[0023] As can be seen from the above embodiments, the multi-channel sampling system and method for online analyzers provided by the present invention achieves at least the following beneficial effects: The multi-channel syringe pump of this invention can sequentially and quantitatively inject the drug solution into the first, second, and third analytical cups, completing the sampling of three analytical items in a short time. This enables variable and quantifiable sampling, precise quantitative sampling, and adjustable sampling volume as needed. When the target concentration of the measured drug solution changes, the sampling volume can be flexibly adjusted, improving the adaptability of the instrument. A single multi-channel syringe pump can meet the sampling requirements of multiple analytical items, simplifying sampling components, thereby reducing electrical control components, lowering the complexity of circuits and pipelines, facilitating maintenance, improving the utilization rate of the internal space of the instrument, achieving the effect of sampling multiple analytical items, and nearly synchronous sampling and analysis of each analytical item. All items can be analyzed in one sampling, saving sampling time and significantly shortening the sampling and overall analysis cycle. The multi-channel syringe pump can be reused, increasing the adaptability of the analytical instrument to different concentrations of drugs.

[0024] While specific embodiments of the invention have been described in detail by way of examples, those skilled in the art should understand that the examples are for illustrative purposes only and not intended to limit the scope of the invention. Those skilled in the art should understand that modifications can be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.

Claims

1. A multi-channel sampling system for an online analyzer, characterized in that, The pump includes a multi-channel syringe pump (25), which is provided with a first channel (1), a second channel (2), a third channel (3), a fourth channel (4), a fifth channel (5), a sixth channel (6), a seventh channel (7), an eighth channel (8), and a ninth channel (9). The first channel (1) is connected to a three-way connector (22) through a second waste discharge pipe (24), and the seventh channel (7) is connected to a three-way connector (22) through a first waste discharge pipe (23). The three-way connector (22) is connected to a wastewater tank. (21) The second channel (2) is connected to the liquid collection tank (11) through the medicine pipe (12), the liquid collection tank (11) is connected to the tank liquid pipe (10), the third channel (3) is connected to the first analysis cup (A1) through the first injection pipe (14), the fourth channel (4) is connected to the second analysis cup (A2) through the second injection pipe (15), the fifth channel (5) is connected to the third analysis cup (A3) through the third injection pipe (17), and the sixth channel (6) is connected to the pure water tank (20) through the pure water pipe (19).

2. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The liquid collection tank (11) is a sampling cup.

3. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The liquid collection tank (11) is a flow container.

4. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The first analytical cup (A1) is used to detect the sulfuric acid content in the etching solution.

5. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The second analytical cup (A2) is used to detect the hydrogen peroxide content in the etching solution.

6. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The third analytical cup (A3) is used to detect the copper ion content in the etching solution.

7. The multi-channel sampling system for an online analyzer according to claim 1, characterized in that, The 8th channel (8) is connected to the fourth analysis cup, and the 9th channel (9) is connected to the fifth analysis cup.

8. A multi-channel sampling method for an online analyzer, characterized in that, The sampling method of the multi-channel sampling system for an online analyzer as described in any one of claims 1-7 includes the following steps: Step S1: Rinse the tubing with a multi-channel injection pump (25); Step S1 includes the following sub-steps: Step S1-1: Switch the multi-channel injection pump (25) to the second channel (2) so that the piston of the second channel (2) performs an injection action; Step S1-2: Switch the multi-channel injection pump (25) to the first channel (1) so that the piston of the first channel (1) performs a discharge action; Step S1-3, switch the multi-channel injection pump (25) to the second channel (2) again, so that the piston of the second channel (2) performs an injection action; Step S1-4: Switch the multi-channel injection pump (25) to the first channel (1) again, so that the piston of the first channel (1) performs the discharge action; Step S2: Based on the required amount of the first analysis cup (A1), switch the multi-channel injection pump (25) to the second channel (2) so that the piston of the second channel (2) performs an injection action; Step S3: Switch the multi-channel syringe pump (25) to the third channel (3) so that the piston of the third channel (3) performs a discharge action and injects a quantitative amount of sample solution into the first analytical cup (A1); Step S4: Based on the required amount of the second analysis cup (A2), switch the multi-channel injection pump (25) to the second channel (2) so that the piston of the second channel (2) performs an injection action; Step S5: Switch the multi-channel syringe pump (25) to the 4th channel (4) so ​​that the piston of the 4th channel (4) performs a discharge action and injects a quantitative amount of sample solution into the second analytical cup (A2); Step S6: Based on the required amount of the third analysis cup (A3), switch the multi-channel injection pump (25) to the second channel (2) so that the piston of the second channel (2) performs an injection action; Step S7: Switch the multi-channel syringe pump (25) to the 5th channel (5) so that the piston of the 5th channel (5) performs a discharge action and injects a quantitative amount of sample solution into the third analytical cup (A3); Step S8: Clean the tubing using a multi-channel syringe pump (25); Step S8 includes the following sub-steps: Step S8-1: Switch the multi-channel injection pump (25) to the 6th channel (6) so that the piston of the 6th channel (6) performs an injection action; Step S8-2: Switch the multi-channel injection pump (25) to the 7th channel (7) so that the piston of the 7th channel (7) performs a discharge action; Step S8-3: Switch the multi-channel injection pump (25) to the 6th channel (6) again, so that the piston of the 6th channel (6) performs an injection action; Step S8-4: Switch the multi-channel injection pump (25) to the 7th channel (7) again, so that the piston of the 7th channel (7) performs the discharge action; Step S9: Switch the multi-channel syringe pump (25) to the 6th channel (6) so that the piston of the 6th channel (6) performs an injection action to extract pure water; Step S10: Switch the multi-channel syringe pump (25) to the 5th channel (5) and make the piston of the 5th channel (5) perform a discharge action to flush the residual sample liquid in the pipeline with pure water to the third analytical cup (A3). Step S11: Switch the multi-channel syringe pump (25) to the 6th channel (6) so that the piston of the 6th channel (6) performs an injection action to extract pure water; Step S12: Switch the multi-channel syringe pump (25) to the 4th channel (4) and make the piston of the 4th channel (4) perform a discharge action to flush the residual sample liquid in the pipeline with pure water to the second analytical cup (A2). Step S11: Switch the multi-channel syringe pump (25) to the 6th channel (6) so that the piston of the 6th channel (6) performs an injection action to extract pure water; Step S13: Switch the multi-channel syringe pump (25) to the third channel (3) so that the piston of the third channel (3) can perform a discharge action and flush the residual sample liquid in the pipeline with pure water to the first analytical cup (A1).

Images