Dry powder inhaler and compressed air medicine spraying device

Abstract

In Figure 1, an inhaler has a compressed air tank (1) with air inlet (2) and air outlet (3) valves. The outlet valve is provided with a nozzle (6) with two injection holes (13) and (14), the medicine injection pipe (4) is provided with a medicine hopper (11), and the detachable suction nozzle (5) is provided with a flange (8) and an inner short column (9) which sequentially form an injection mechanism. A medication strip (26) is located within the medication channel of the cross arm (27). A depressible puncture needle (29) disposed in a spring chamber (28) pierces the strip of medicament such that medicament falls into the medicament hopper (11) and into the injection tube bottom (15). The air inlet (18) has a bellows (48) for charging compressed air. During use, the air box is inflated firstly, and then the medicine strip (26) is punctured. The mouthpiece is held in the mouth, inhaled and depressed the outlet valve (3), whereby a soft laminar flow with a drug spray (49) and a peripheral low drug concentration channel (50) will flow into the lung.

Description

TECHNICAL FIELD

[0001] The present invention relates to a new type of dry powder inhaler that uses a new type of compressed air rather than gas propellant to create an easily aerosolized powder spray for the delivery of medication to the lungs of asthma and chronic obstructive pulmonary disease (COPD) patients. BACKGROUND

[0002] Inhalers have been used to deliver medication to asthma patients for decades. There are two types of inhalers currently in use: metered dose inhaler (MDI) that uses a fluorinated alkane propellant to aerosolize the medication; and dry powder inhaler (DPI) that uses the flow rate and velocity of the patient's inhalation to create a spray of medication. Both have efficiencies of only 10-15% and both have shortcomings that lead to use failure.

[0003] The shortcomings of the metered dose inhaler include:

[0004] 1. The inhalation action is fast and shallow, resulting in poor delivery of the medication to the lungs.

[0005] 2. The canister must be pressed hard at the beginning of the inhalation to initiate the spray, and the medication is delivered to the lungs.

[0006] 3. There is difficulty in coordinating the pressing of the canister with the early inhalation action, and about 80% of patients have this problem, resulting in repeated wastage of the dose.

[0007] 4. A dose counter must be provided to indicate that the inhaler is running out.

[0008] 5. A spacer must be used in conjunction, adding cost and plastic waste.

[0009] 6. There is a need to develop a propellant-free spray of medication to greatly reduce the ecological impact on the warming of the upper atmosphere.

[0010] Dry powder inhalers are not perfect either:

[0011] 1. The inhalation flow is the source of power to create the spray in the swirl chamber.

[0012] 2. The spray of medication particles is often in large agglomerates, with more deposition in the mouth than in the lungs.

[0013] 3. The spray is wide and further increases the deposition in the mouth.

[0014] 4. Patients who inhale shallowly cannot create a good spray of medication.

[0015] 5. The current generation of dry powder inhalers used by patients still have the problem of poor spray formation. There is a problem of failure to use the existing inhalers, including dry powder inhalers and metered dose aerosol inhalers. Why not create a new dry powder inhaler with better spray performance?

[0016] Technical problem

[0017] Inhalers are the preferred route of administration for delivering drugs to the lungs for the treatment of asthma and chronic obstructive pulmonary disease (COPD). The mouth is about 6 cm in the horizontal direction, and then it turns 90 degrees downward at the pharynx, which is about 3 cm wide, and then the trachea, which is about 1.5 to 2 cm in diameter, further branches into bronchi into the two lungs. How to effectively deliver the drug spray in such a complex airway path? A fine and concentrated drug flow path with a diameter of about 1.5 cm can deliver more drugs than the divergent spray of the existing metered dose aerosol inhalers or dry powder inhalers. The drug in the inhaler is a soft particle treated by micronization and mixed with a filler, and the total amount is less than 1 gram! It is technically difficult to form a soft drug spray for such drugs.

[0018] The defects of metered dose aerosol inhalers and dry powder inhalers are as follows:

[0019] 1. The lung deposition rate is only 10-15%.

[0020] 2. The mouth deposition of dry powder inhalers is more obvious, and the spray deposited in the mouth needs to be removed by gargling.

[0021] 3. The spray formed by the existing metered dose aerosol inhalers and dry powder inhalers is wider than the diameter of the trachea, which is not suitable for the anatomical structure of the mouth, throat and trachea.

[0022] 4. There is no ideal inhaler suitable for both shallow breathers and deep breathers.

[0023] 5. Formation and transmission path of drug spray: it needs to be transmitted in the horizontal slit of 6-7 cm in the mouth, and then it turns 90 degrees downward at the throat which is about 3 cm wide, and then it further branches into the bronchi of the two lungs, so it needs to form a narrow drug spray channel with a width of about 1.5 cm.

[0024] 6. The airway of children is narrower and shorter.

[0025] Solution to the problem

[0026] The new dry powder inhaler ("DPI") has a completely new structure and function. The dry powder inhaler can form a soft drug spray about 1 cm wide in a peripheral low drug concentration laminar air flow channel for pulmonary drug delivery. The dry powder inhaler is provided with a new compressed air chamber as an energy source to spray the drug into a soft spray. The new compressed air channel is provided with a special spray nozzle for easy drug loading. The mouthpiece structure is also innovatively designed to form a central drug flow path and a peripheral low drug concentration laminar spray path, thereby reducing oral deposition. The compressed air drug spray forming mechanism is also innovatively designed with a regulator or valve for storing compressed air and releasing it when the device is used for inhalation.

[0027] Therefore, the purpose of the present application is to propose a solution to improve the pulmonary deposition rate and reduce the waste of drugs on both sides of the oral cavity. Extensive searches have been conducted on the Internet, and relevant patent documents have been studied, especially those related to dry powder inhalers using compressed air drug spray. Since the present application has fundamental differences in using compressed air as the power source for drug spray and having an innovative mouthpiece structure (forming a laminar central drug flow path), the inventors were unable to retrieve relevant patent documents in existing databases. After searching the United States Patent and Trademark Office, the European Patent Office and other databases, existing literature and inhaler enterprise literature, no dry powder inhaler similar to the present application was found, which has a laminar central drug spray path and uses compressed air instead of gas to form a drug spray. There is no dry powder inhaler that uses compressed air to form a laminar drug spray. No gas is needed, i.e. no container, tank or chemical propellant and its pollution. The present application is not a simple production workshop improvement, but a gradual research over several months, including the development of new mouthpiece design, drug falling structure, spray forming mechanism, compressed air cavity and matching between parts. No dry powder inhaler with similar structure or function was found in the patent classification database, market and other materials. At present, no prior art dry powder inhaler with similar structure or function can be cited as a comparison. SUMMARY

[0028] The new dry powder inhaler has four new improvements. 1. The device is provided with a compressed air tank, which has an air inlet connected to a compressed air source and provided with an on / off inlet regulator / valve, and an air outlet provided with an outlet regulator / valve. 2. The outlet valve leads to a new air jet nozzle, which is not provided with only one, but two or more air jet holes for spraying medicine. 3. The air jet nozzle is fitted with a medicine spray tube, which is filled with medicine by a capsule or medicine strip and provided with a spring-driven puncture needle. 4. The medicine spray tube is fitted with a mouthpiece designed to form a laminar flow-air flow path structure. The spray width is now reduced, which can pass through the throat and trachea, thereby improving the lung deposition rate and improving the relief effect. The method of use is as follows: air is filled into the air tank through the air inlet bellows, syringe or micro motor, and the air inlet regulator / valve is closed. The medicine is filled into the medicine spray tube from the capsule or strip. The mouthpiece is placed in the mouth. Slow and long inhalation. Release the outlet regulator at the beginning of inhalation. Compressed air will spray the medicine into a fine and narrow central high drug concentration channel path, while forming a peripheral air sheath layer under the action of inhalation of the mouthpiece. The laminar flow medicine spray has a structure of high central drug concentration and low peripheral channel drug concentration, which is an innovative design. Even children and the elderly can achieve better therapeutic effect. BRIEF DESCRIPTION OF DRAWINGS

[0029] The above and other objects and features of the present application will become more apparent from the following description taken in conjunction with the accompanying drawings, in which:

[0030] Figure 1 Details of the structure of the new dry powder inhaler are shown.

[0031] Figure 2 Details of the structure of the new dry powder inhaler are shown.

[0032] Figure 3 The valve structure provided with a spring in the air tank, and the plunger below the cover are shown.

[0033] Figure 4 The improved structure of the valve is shown, with the spring and plunger above the cover.

[0034] Figure 5 The cock valve is shown.

[0035] Figure 6 The inlet valve with a syringe for air charging into the air tank is shown.

[0036] Figure 7 The inlet valve with an air bag for air charging into the air tank is shown.

[0037] Figure 8A micro electric pump for inflating is shown.

[0038] Figure 9 A drug is shown falling in a transparent drug ejection tube and the process of spray formation.

[0039] Figure 10 An inhaler is shown in use in the mouth and delivering a spray to the lungs.

[0040] Figure 11 An inhaler is shown with a circular air chamber. DETAILED DESCRIPTION

[0041] The following specification describes the salient features, method of construction, method of use and advantages of the present invention.

[0042] The present dry powder inhaler is provided with a portable compressed air chamber, an air inlet, a valve, a drug loading ejection tube and a mouthpiece for spray formation and inhalation, and is novel and aesthetically pleasing in appearance. It can be carried in a shirt pocket.

[0043] The present dry powder inhaler is more optimal because the compressed air spray is narrower and softer than the spray formed by the chemical propellant of a metered dose aerosol inhaler. The present device is easy to set up, operate and use, even by illiterates or children. The device also has the advantage of environmental protection, no chemical pollution, and provides better relief for the user!

[0044] The new device has higher efficiency due to the use of compressed air to form a narrow drug spray and the use of a new mouthpiece with a central drug flow path and less drug flow in the periphery. The laminar drug structure in the air stream is new for asthma inhalers. Dry powder inhalers have not been improved for a long time. The purpose of the invention is to overcome the inherent deficiencies of existing dry powder inhalers, and for this purpose the new invention is proposed. The new dry powder inhaler is superior to other powder inhalers. The new dry powder inhaler is easy to use and maintain, and can save health and cost. Inhaler research is complex and difficult: 1. Forming a spray of less than 1 mg of drug and filler chemicals. The chemical propellant in the metered dose aerosol inhaler is ejected at high speed, and the evaporation of the propellant will exacerbate global warming. In existing dry powder inhalers, the inhalation force used by patients to form a spray is often insufficient. The new dry powder inhaler uses compressed air to form a correct, good and soft spray. The device also has repeatability. 2. The increased volume of compressed air in the device, together with the air inhaled by the patient, delivers more oxygen to the lungs. 3. The mouthpiece diameter is 1 cm, suitable for adults, and can form a slow and longer deep inspiration, thereby providing more time for the drug spray to reach the deep part of the lungs. 4. The inhaler can also be used as a deep inspiration physical therapy device to increase lung elasticity. All existing asthma and chronic obstructive pulmonary disease drugs can be used in strip or capsule form! For children, a smaller mouthpiece can be used, and parents can trigger the drug spray!

[0045] The new inhaler has four modules: 1. Compressed air element; 2. Drug falling element; 3. Air jet element for forming a correct and soft spray; 4. New mouthpiece with central laminar drug channel and peripheral low drug channel to reduce oral deposition. In existing metered dose aerosol inhalers and dry powder inhalers, only two elements are included, namely the drug delivery part and the drug flow cyclone airway part in the inhaler body to form a wide spray and produce large oral deposition. There is no central laminar drug flow!

[0046] We propose to name the new parts of the inhaler to reduce confusion. The compressed air tank or chamber is called "box" because its size is similar to a matchbox, easy to carry in a pocket. The regulator or valve of the air inlet or air outlet is uniformly called "valve".

[0047] The device is a new device with a portable air box, see Figure 1 . The air box is provided with an air inlet 2 and an air outlet 3. The size of the box can be 4x3x5 cm (three matchbox sizes), can withstand 0.5 kg air pressure, suitable for adult hand or placed in the pocket, easy to use and carry. The air inlet 2 is provided with a valve with a finger button 16 for opening or closing to charge or lock compressed air into the air box. The inlet 18 of the valve is matched with the nozzle 39 of the syringe 40Figure 6 ), or bellows 48 (Fig. 1) Figure 7 ), or micro electric air pump 42 (Fig. 1) Figure 8 ) to inflate the air chamber.

[0048] The air chamber outlet 3 is provided with an outlet valve having a top finger button 16 for finger pressing. The button closes the air outlet by spring 24. The valve is provided with an air outlet jet nozzle 6 (Fig. 1) Figure 2 , Figure 9 ) having two pinhole jet holes 13, 14. The lower jet hole 13 is for jetting the medicine deposited at the bottom 15 of the jet tube, and the upper jet hole 14 is for pushing the medicine spray into the mouth without forming deposition inside the jet tube. The jet tube 4 is provided with an upper medicine hopper 11 for dropping the medicine into the bottom 15 of the jet tube in front of the nozzle jet holes 13, 14. The medicine hopper is provided with a top medicine strip 26 (Fig. 1) Figure 2 , Figure 9 ) and a piercing needle 29. The front end 7 (Fig. 1) Figure 2 ) of the medicine jet tube 13 (Fig. 1) Figure 2 ) is smaller than the rear end 12 to increase the spray speed. The narrow front end can form higher medicine speed under the action of air jet and reduce the internal deposition. The medicine jet tube 4 is connected to the rear side of a detachable mouthpiece 5 (Fig. 1) Figure 1 , Figure 2 ). The mouthpiece 5 is a tubular structure gradually narrowing from the rear to the mouth side 10 to increase the spray speed and reduce the internal deposition of the mouthpiece, thereby forming a soft spray of the best size; the rear part is provided with an expansion part 8 for collecting more air when inhaling and forming a laminar flow with an internal high medicine concentration air channel 49 (dashed line) and a peripheral low medicine concentration channel path 50. Figure 11 The spray structure shown can prevent the medicine from adhering to the inside of the mouthpiece. A short column 9 is provided inside the rear part of the mouthpiece 5 or outside the medicine jet tube 4, forming an air space 47 (Fig. 1) Figure 10 ) between the mouthpiece and its internal medicine jet tube. The air space 47 helps the outside air to form the peripheral channel 50 during inhalation, together with the internal medicine spray 49 (Fig. 1) Figure 9 ) to form a laminar flow (Fig. 1) Figure 9 , Figure 1 ) so that the entire medicine spray enters the oral cavity and airway.

[0049] The medicine falling element includes two support columns (25) (Fig. 1) Figure 2) and a horizontal arm (27), the horizontal arm having a drug strip channel for mounting the selected drug strip 26. The horizontal arm (27) has a spring cavity 28, and a drug strip puncture needle 29 is provided in the cavity. The top of the puncture needle 29 has a wide and flat finger pressing plate to press the puncture needle, so that it punctures the drug strip and the drug falls into the drug hopper 11 and bottom 15 of the lower drug spray pipe 4. Figure 9 In this process, a drug spray is formed. The sharp puncture needle may have a three- or four-sided structure to cut and form holes, and keep the holes open to facilitate the powder falling into the drug hopper 11. The drug strip may be a spool-type structure that can be rotated for subsequent use. For clarity, the drug strip spool is not shown.

[0050] For capsule puncture, the puncture needle can be designed to be thicker. The capsule can be placed in a higher drug hopper to accommodate it. The puncture needle rises under spring action for the next drug use. This structure is not shown because strips are less expensive and offer better drug preservation over a longer period. The capsules require moisture-proof drying. The capsule is placed in the hopper, and the puncture needle is pressed into the hopper, causing the drug to fall into the injection tube.

[0051] The air box ( Figure 2 The cover 19 can be a rectangular box with a sealing gasket 23. Screws 22 are used to fix the cover and ensure no air leakage. The airtight connection between the cover and the box can also be achieved by press fitting or bonding. The cover has a short pipe with an air inlet 20 and an air outlet 21 for connecting the air inlet valve 2 and the air outlet valve 3. The short column 23 is used to install the drug drop support column (25).

[0052] The compressed air chamber can be inflated using a syringe 40 ( Figure 6 ) or bellows or airbag 48 ( Figure 7 (Similar to a device used for blood pressure measurement cuffs) is used. Figure 7 The diagram shows a structure with a rubber tube 41 and a nozzle 39, the nozzle 39 being adapted to the air inlet 18 of the air inlet valve 2. The nozzle 39 of a syringe, bellows, or airbag is adapted to the air inlet 18 to inflate the airbox.

[0053] Figure 3 The valve shown has a valve body and a plunger 30, the plunger having a top leak-proof seal 17 and a top finger button 16. The plunger has a plate 31 with a soft rubber coating to prevent air leakage within the air chamber 2. Under normal conditions, a spring keeps the plunger plate in the closed position. When the plunger is pressed, the spring is compressed, air flows into the air outlet and into the air jet orifice to blow out the drug to form a spray. Figure 3 Arrows indicate the valve's open state and the direction of airflow.

[0054] Figure 4 Another valve configuration is shown. The plunger 30 and its spring 24 are located on the side of the valve. The plunger base seals the hole 52 between the valve and the air chamber. The plunger is provided with an outer cylinder 32, a top pivot 34, and a finger button 33. When the finger button 33 is pressed, the plunger 16 is lifted by the pivot 34, opening the hole 52 in the bottom of the valve. Air then enters the air jet hole to create a spray. When the finger button is released, the spring 24 closes the hole 52 for the next use.

[0055] Figure 5 A stopcock valve is shown with a handle 37 that rotates a rubber cylinder 35, aligning its air hole 36 with the outlet for air jetting. A seal is provided to prevent air leakage. A top chamber 38 is provided to secure the rubber cylinder for long term use. The handle 37 can be rotated to close the valve for the next use.

[0056] Figure 6 A miniature electric pump 42 is shown with a circuit board 43, battery 44, and USB interface 45 to provide power. The motor can also be a DC type for easy use. It is connected to the air inlet to inflate the air chamber. A clear plastic air pressure indicator 51 with a colored float can be installed on the lid or air chamber to show the pressure before use. Electronic pressure display devices can also be used in the electric pump model. A valve with a longer plunger and top finger button can also be used with a valve core for vehicle tires, which is not shown in the figures. The method of use is as follows: Connect the bellows 48 or syringe 40 to the air inlet 18 of the inlet valve 2. Keep the inlet valve open. Press the bellows or syringe to create air pressure, then close the inlet valve. At this time, the compressed air is sealed in the air chamber. Place the drug strip 26 in the drug channel of the cross arm (27) (see Figure 2 ), or place the capsule in the hopper 11 and puncture it by pressing the puncture needle 29. The drug falls into the bottom area 15 of the drug jet tube 4, before the air jet nozzle holes 14, 13 (see Figure 9 ). Place the mouthpiece in the inlet and inhale (see Figure 10 ). Press the air outlet valve 3 at the beginning of inhalation. The compressed air flows from the air chamber through the outlet valve, nozzle needle hole jet hole, and sprays the drug into an elongated spray, forming a laminar central path (see Figure 10 , Figure 9 ), with an internal high drug concentration channel 49 (dashed line) and an external low drug concentration channel 50. This laminar structure is a new design and reduces oral deposition.

[0057] During inhalation, external air flows between the jet tube 4 and the short post 9 behind the mouthpiece 5, separating the jet tube 4 and the mouthpiece 5 by a few millimeters for the inhalation air flow (see Figure 10The compressed air and the natural breath air flow into the air chamber 1, through the inlet valve 2, and exit through the outlet valve 3, forming a central high drug concentration path 49 and a peripheral low drug concentration path 50 (as indicated by the arrows 47), confining the drug to the central high drug concentration path 49 and the peripheral low drug concentration path 50 Figure 9 ). Oral deposition is reduced. This is the first time that laminar air drug spray into the lungs is achieved in any inhaler.

[0058] The additional air from the compressed air and the natural breath air facilitates lung drug deposition. After holding breath for 10 seconds, the mouthpiece is removed for the next use.

[0059] The air chamber, its cover, the mouthpiece, the drug ejection tube, the support column, the drug strip path, the air ejection nozzle, and the valve can be made as separate small parts by injection molding and then assembled. The mouthpiece is detachable. The part materials can be plastic or metal. The ejection tube and the mouthpiece can be made of non-stick transparent medical grade plastic.

[0060] The device can be improved. Different sizes can be made for children or adults. The air chamber can be made of plastic or metal. The air inlet and outlet of the air chamber, together with the valve, can be arranged on the side or the bottom. The air inlet valve / regulator can be made of a spring driven structure to reduce the operating force. The air outlet valve can be made of other types, such as the press type structure shown in Figure 3 、 Figure 4 and Figure 5 . The ejection nozzle needle hole can be three. The hopper can be provided with a spring driven strip / capsule piercing structure to facilitate drug loading. Figure 11 The air chamber of the inhaler shown can be round or other shapes, with an airtight cover. The inlet valve can be arranged inside the chamber.

[0061] The advantages of the new invention are:

[0062] 1. The new air chamber forms a compressed air spray source for effective drug spray.

[0063] 2. The inlet valve helps to seal and close the air to form a compressed air source.

[0064] 3. The spring in the valve keeps the air locked for use when needed.

[0065] 4. The handle of the outlet valve is a low force trigger structure for releasing the drug spray.

[0066] 5. The air ejection nozzle hole forms a non-agglomerated, de-agglomerated drug spray.

[0067] 6. The hopper with an easy-to-use drug strip piercing needle helps the drug to fall into the tube.

[0068] 7. The mouthpiece is a new structure that can form a central laminar drug flow path and a peripheral lower drug flow path.

[0069] 8. This device is portable and easy to use.

[0070] 9. Reduced oral deposits allow for slow, deep inhalation, which increases drug deposition in the lungs.

[0071] 10. Compressed air increases the volume of air and oxygen in the lungs, which is helpful for asthma patients.

[0072] 11. Pressure sensors can be used to indicate the required pressure for spraying. Claims (as amended under Article 19 of the Treaty) 1. A dry powder inhaler with compressed air drug spray, comprising: (a) A compressed air component, including an air box (1), the air box having an air inlet and its valve (2), and an air outlet and its valve (3); (b) A drug spraying element, including an air outlet valve (3), a spray nozzle (6), a drug drop and spray pipe (4), and a suction nozzle (5), wherein the above components are arranged sequentially along the same axis; (c) A drug drop element, including a support column (25), the support column having a cross arm (27), the cross arm having a drug strip channel (26) and a drug strip, and a drug strip puncture needle (29) having a spring (28). 2. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the air box includes a box body (1), a cover (19), a sealing gasket (23) to prevent air leakage, an air inlet valve (2) with an air inlet (18), an air outlet valve (3) with an air outlet nozzle, and a drug drop support column (25) is provided on the outside of the cover body. 3. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the drug spray tube (4) comprises a transparent tube body having an air spray end (12), a narrower mouthpiece end (7) and an upper drug collection hopper (11). 4. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the mouthpiece (5) includes a tubular structure having an air collection flange (8) located at the end of the drug spray tube and a narrower end (10), and a short post (9) is provided on the inner side of the mouthpiece. 5. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the drug drop element includes two support columns (25), a cross arm (27), a drug strip channel (26) disposed in the cross arm (27), a drug strip puncture chamber provided with an internal spring (28) and a puncture needle (29), wherein the puncture needle is provided with a top finger button. 6. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the jet air nozzle (6) is provided with at least two jet holes (13), (14), one jet hole (13) is located near the bottom of the drug jet tube (15), and the other upper jet hole (14) is used to push the drug to form a spray. 7. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the valve is provided with a plunger (30) having a bottom plate (32), a plunger spring (24), a leak-proof seal (17), and an upper finger button (16), and is configured to be movable from a closed position to an open spray release position. 8. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the plug valve is provided with a handle (37), a shaft with a rubber cylinder (35), and an air passage (36), and is provided with a leak-proof seal structure at the top cover (38). 9. The dry powder inhaler with compressed air drug spray according to claim 1, wherein an electric micro motor pump (42) and its battery (44), control circuit (43) constitute a compressed air source. 10. The dry powder inhaler with compressed air drug spray according to claim 1, wherein the air tank is provided with a pressure indicator (51).

Claims

1. A dry powder inhaler with compressed air drug spray, comprising: (a) A compressed air component, including an air box (1), the air box having an air inlet and its valve (2), and an air outlet and its valve (3); (b) A drug spraying element, including an air outlet valve (3), a spray nozzle (6), a drug drop and spray pipe (4), and a suction nozzle (5), wherein the above components are arranged sequentially along the same axis; (c) A drug drop element, including a support column (25), the support column having a cross arm (27), the cross arm having a drug strip channel (26) and a drug strip, and a drug strip puncture needle (29) having a spring (28).

2. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the air box includes a box body (1), a cover (19), a sealing gasket (23) to prevent air leakage, an air inlet valve (2) having an air inlet (18), an air outlet valve (3) having an air outlet nozzle, and a drug drop support column (25) provided on the outside of the cover body.

3. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the drug spray tube (4) comprises a transparent tube body having an air spray end (12), a narrower mouthpiece end (7) and an upper drug collection hopper (11).

4. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the mouthpiece (5) comprises a tubular structure having an air collection flange (8) located at the end of the drug spray tube and a narrower end (10), and a short post (9) is provided on the inner side of the mouthpiece.

5. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the drug drop element comprises two support columns (25), a cross arm (27), a drug strip channel (26) disposed in the cross arm (27), and a drug strip puncture chamber provided with an internal spring (28) and a puncture needle (29), wherein the puncture needle is provided with a top finger button.

6. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the spray air nozzle (6) is provided with at least two spray holes (13) and (14). One of the injection holes (13) is located near the bottom (15) of the drug injection tube, and the other upper injection hole (14) is used to push the drug to form a spray.

7. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the valve is provided with a plunger (30) having a base plate (32), a plunger spring (24), a leak-proof seal (17) and an upper finger button (16), the plunger being configured to move from a closed position to an open spray release position.

8. A dry powder inhaler with compressed air drug spray according to claim 1, wherein the stopcock valve is provided with a handle (37), a shaft with a rubber cylinder (35) and an air passage (36), and a leak-proof sealing structure is provided on the top cover (38).

9. A dry powder inhaler with compressed air drug spray according to claim 1, wherein an electric micro motor pump (42) and its battery (44) and control circuit (43) constitute a compressed air source.

10. A dry powder inhaler with compressed air drug spray as claimed in claim 1, wherein the air chamber is provided with a pressure indicator (51).

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