Application of novel dehydrated podophyllol compound in preparation of programmed death ligand-1 protein degradation agent
The new dehydrated podophyllotoxin compounds mediate PD-L1 protein degradation, solving the problems of high cost or insufficient efficacy of existing PD-L1 regulation strategies and achieving highly efficient anti-tumor immune activation effects.
CN121731289APending Publication Date: 2026-03-27隋新兵
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-09
- Publication Date
- 2026-03-27
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Figure CN121731289A_ABST
Abstract
The invention provides application of a novel dehydrated podophyllol compound in preparation of a degradation agent for programmed death ligand-1 protein, and particularly belongs to the technical field of natural product pharmacy. The new dehydrated podophyllol compound comprises new dehydrated podophyllol and / or a derivative thereof, and the new dehydrated podophyllol compound can down-regulate the expression of programmed death ligand-1 (PD-L1), specifically can reduce the expression quantity of tumor cell PD-L1 protein, enhances the anti-tumor immune response, and can be used for preparing the anti-tumor drug. The novel dehydrated podophyllol compound can be used as an anticancer candidate drug for development and application of related preparations.
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