Automatic preloaded reagent mixing device

Abstract

The invention discloses an automatic preloaded reagent mixing device, and relates to the technical field of reagent mixing devices for medical detection and biological experiments, the automatic preloaded reagent mixing device comprises a dry powder pressing rod, the upper end of the dry powder pressing rod is provided with a pushing part, the lower end of the dry powder pressing rod is provided with a groove-shaped hole, and two sides of the groove-shaped hole are symmetrically provided with recesses; the sealing outer sleeve is arranged on the outer side of the dry powder pressing rod in a sleeving manner and is in sealing fit with the recess; the microsphere dry powder reagent is preloaded in a cavity formed by the groove-shaped hole of the dry powder pressing rod and is sealed by the sealing jacket; the plasma cup is a hollow columnar container, an opening of the plasma cup is connected with the sealing outer sleeve in a matched mode so as to form a sealed mixing cavity for containing a liquid sample, the dry powder pressing rod and the elastic sealing outer sleeve are matched in a sliding and sealing mode, preloading and long-term stable storage of a microsphere dry powder reagent are achieved, and the reagent is effectively prevented from being affected with damp, polluted and invalid; and a one-key pressing type release structure is adopted, so that the operation steps are obviously simplified.

Description

Technical Field

[0001] This invention relates to the field of reagent mixing devices for medical testing and biological experiments, specifically an automatic pre-filled reagent mixing device. Background Technology

[0002] In the fields of medical testing and biological experiments, it is often necessary to precisely and thoroughly mix solid dry powder reagents with liquid biological samples (such as plasma) to initiate or complete a reaction. This mixing process is a critical step in the pretreatment of many in vitro diagnostic and experimental analyses, and its efficiency and reliability directly affect the accuracy and timeliness of subsequent test results.

[0003] Currently, the main methods for mixing dry powder reagents and liquid samples include manual operation and the use of automated mixing equipment. Manual operation typically involves using separate reagent containers, with the operator weighing, adding, and shaking to mix. On the other hand, there are also some automated or semi-automated mixing instruments on the market designed to replace some manual steps and increase throughput.

[0004] However, existing mixing methods still have several shortcomings. Manual operation is not only cumbersome and inefficient, but also prone to dosage errors and cross-contamination risks due to individual operator differences. Existing automated mixing devices are often complex in structure and expensive, and are difficult to integrate effectively with single-use pre-packaged reagents, failing to achieve simple and rapid on-site mixing while ensuring stable reagent preservation (such as moisture and contamination prevention). Summary of the Invention

[0005] Based on this, the purpose of the present invention is to provide a pre-filled reagent automatic mixing device to solve the technical problems in the prior art, such as the difficulty in pre-filling and sealing dry powder reagents, the cumbersome and complicated operation steps, and the complex structure and high cost of the automatic mixing device.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a pre-filled reagent automatic mixing device includes a dry powder pressure rod, which has a pusher at its upper end and a groove-shaped hole at its lower end, with recesses symmetrically arranged on both sides of the groove-shaped hole; a sealing jacket, which is fitted over the outside of the dry powder pressure rod and seals with the recesses; microsphere dry powder reagent, which is pre-filled in the cavity formed by the groove-shaped hole of the dry powder pressure rod and sealed by the sealing jacket; and a plasma cup, which is a hollow cylindrical container, with its opening adapted to the sealing jacket to form a sealed mixing cavity for containing liquid samples.

[0007] By adopting the above technical solution, the sliding seal between the dry powder lever and the sealing jacket enables the pre-packaging and long-term preservation of microsphere dry powder reagents. When in use, simply press the dry powder lever to release the reagent into the plasma cup. The operation is simple, the seal is reliable, and it is suitable for point-of-care testing scenarios.

[0008] The present invention is further configured such that the dry powder press rod is a T-shaped columnar structure.

[0009] By adopting the above technical solution, the T-shaped columnar dry powder press rod is easy to hold and apply force, and its top push part provides the operator with a clear pressing position, which enhances the convenience of use and ergonomic design.

[0010] The invention is further configured such that the sealing jacket is made of an elastic sealing material, and its inner side is provided with a slide that is adapted to the dry powder pressure bar.

[0011] By adopting the above technical solution, the sealing jacket made of elastic sealing material can form a tight sliding seal with the recessed part of the dry powder press rod, which not only ensures the moisture and pollution prevention of the reagent during storage, but also ensures the reliability and smoothness of the seal during the pressing process.

[0012] The present invention is further configured such that the elastic sealing material is medical rubber or medical silicone.

[0013] By adopting the above technical solutions, medical rubber or medical silicone materials have good biocompatibility, elasticity and sealing performance, making them suitable for medical testing scenarios and ensuring the safety and reliability of reagent storage and use.

[0014] The present invention is further configured such that the plasma cup is made of transparent medical plastic.

[0015] By adopting the above technical solution, the plasma cup made of transparent medical plastic makes it easier for users to observe the mixing state of the internal liquid sample and reagents, improving the intuitiveness and controllability of the operation.

[0016] The present invention is further configured such that the plasma cup has anti-slip texture on its cup wall.

[0017] By adopting the above technical solution, the anti-slip texture design on the cup wall enhances the stability of the user's grip and makes it easy to gently shake the cup after the reagent is released to promote the full mixing of the reagent and the sample.

[0018] The present invention is further configured such that the microsphere dry powder reagent is activated carbon microspheres adsorbed with detection reagents.

[0019] By adopting the above technical solution, using activated carbon microspheres adsorbed with detection reagents as dry powder reagent carriers, not only is the stability and shelf life of the reagents improved, but also the large specific surface area of ​​the reagents facilitates rapid dissolution and reaction, thereby improving detection efficiency and accuracy.

[0020] In summary, the present invention has the following main beneficial effects: This invention achieves pre-loading and long-term stable storage of microsphere dry powder reagents through the sliding seal cooperation between the dry powder pressure rod and the elastic sealing jacket, effectively preventing reagents from getting damp, contaminated, and becoming ineffective. Its one-button press-release structure significantly simplifies the operation steps, improving mixing efficiency and dosage accuracy while avoiding errors and contamination risks that may be introduced by manual operation. The overall device has a compact structure, simple components, and is easy to assemble, balancing low-cost production and convenient consumable replacement. It effectively solves the problems of poor reagent storage stability, cumbersome operation, and complex and expensive automated equipment in existing technologies. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is an exploded view of the structure of the present invention; Figure 3 This is a schematic diagram of the dry powder microspheres before filling according to the present invention; Figure 4 This is a schematic diagram of the dry powder microsphere reagent of the present invention; Figure 5 This is a schematic diagram of the packaging of the standard reagent of the present invention; Figure 6 This is a schematic diagram of the release dry powder microsphere reagent of the present invention.

[0022] In the diagram: 1. Dry powder pressure bar; 2. Sealing jacket; 3. Plasma cup; 4. Anti-slip texture; 5. Microsphere dry powder reagent. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0024] The embodiments of the present invention will now be described.

[0025] An automatic mixing device for pre-filled reagents, such as Figures 1 to 6 As shown, it includes a dry powder press rod 1, a sealing jacket 2, a plasma cup 3, and microsphere dry powder reagent 5. Figure 1 and Figure 2 As shown, in the assembled and used state, the sealing jacket 2 is fitted over the outer side of the dry powder press rod 1, and the two together constitute an operable pre-assembled assembly. This pre-assembled assembly is adapted to the mouth of the plasma cup 3 through the lower end of the sealing jacket 2, thereby forming a top-sealed mixing cavity inside the plasma cup 3.

[0026] like Figure 2 , Figure 3 and Figure 4As shown, the dry powder press rod 1 has an overall T-shaped columnar structure. Its upper end is a push-down section for the user to apply downward pressure. A slotted hole is formed at the end of its thinner section, penetrating both sides of the rod body to create a cavity inside for accommodating the microsphere dry powder reagent 5. Crucially, symmetrical annular recesses are machined on the two sides of the rod wall corresponding to the location of the slotted hole.

[0027] like Figure 2 , Figure 3 and Figure 4 As shown, the sealing sleeve 2 is a cylindrical component whose inner diameter matches the outer diameter of the dry powder press rod 1. The sealing sleeve 2 is preferably made of an elastic sealing material, such as medical rubber or medical silicone. Its inner side may have an annular protrusion or interference fit structure that mates with the recess on the dry powder press rod 1 to achieve a sliding seal. When the sealing sleeve 2 is fitted onto the dry powder press rod 1 and slides until its inner sealing structure engages or tightly fits the recess of the dry powder press rod 1, the groove-shaped cavity at the lower end of the dry powder press rod 1 can be sealed from the outside. Figure 5 The state shown.

[0028] like Figure 1 , Figure 2 and Figure 6 As shown, the plasma cup 3 is a hollow cylindrical container used to hold liquid samples such as plasma. The inner diameter or structure of its opening is designed to closely fit the outer diameter or lower shape of the sealing sleeve 2, so that when the pre-assembled component is inserted, the sealing sleeve 2 can form a sealed connection with the opening, preventing liquid leakage or gas ingress. The plasma cup 3 is preferably made of transparent medical plastic to facilitate observation of the internal mixing process by the operator. Anti-slip textures 4 are provided on the outer wall of the plasma cup 3. Figure 1 and Figure 6 As shown, this is to facilitate the user's grip and shaking operation.

[0029] like Figure 2 , Figure 4 and Figure 5 As shown, the microsphere dry powder reagent 5 is a pre-loaded reagent carrier of the present invention. In a preferred embodiment, it is a medical-grade activated carbon microsphere, which has been adsorbed with specific dry powder reagent components required for detection or experimentation and has undergone drying treatment. In the pre-loaded state, a quantitative amount of the microsphere dry powder reagent 5 is loaded into the groove-shaped cavity at the lower end of the dry powder pressure rod 1, as shown. Figure 4 As shown.

[0030] During the pre-sealing stage, see Figures 3-5 First, the sealing jacket 2 is fitted onto the rod portion of the dry powder press rod 1. For example... Figure 3As shown, initially, the sealing sleeve 2 can be placed at a lower position on the rod, exposing the groove-shaped cavity at the lower end of the dry powder press rod 1. Then, as... Figure 4 As shown, a measured amount of the microsphere dry powder reagent 5 is filled into the exposed cavity. Then, as... Figure 5 As shown, the sealing jacket 2 is pushed upward so that its inner sealing structure engages with the recessed part of the dry powder pressure rod 1, thereby completely sealing the cavity containing the microsphere dry powder reagent 5, forming a pre-packaged reagent assembly that can be stored, is moisture-proof and pollution-proof.

[0031] In use, first inject a measured amount of liquid sample (such as plasma) into the plasma cup 3. Then, invert the assembly of the dry powder press rod 1 and the sealing jacket 2, which is already filled with microsphere dry powder reagent 5 and is in a sealed state, and insert it into the mouth of the plasma cup 3. At this time, the sealing jacket 2 is sealed to the mouth of the cup, and the grooved end of the dry powder press rod 1 is suspended above the liquid surface. The user presses down on the push part of the dry powder press rod 1, and the dry powder press rod 1 moves downward relative to the fixed sealing jacket 2. When the grooved cavity at the lower end of the dry powder press rod 1 moves downward and falls out of the sealing range of the sealing jacket 2, the microsphere dry powder reagent 5 in the cavity automatically falls into the liquid sample below under the action of gravity. Subsequently, the user can gently shake the cup by holding the anti-slip texture 4 on the plasma cup 3 to accelerate the dispersion of the microsphere dry powder reagent 5 and the dissolution of the reagent, thereby achieving rapid, sufficient, and automatic mixing of the reagent and the sample.

[0032] In summary, the pre-filled reagent automatic mixing device of the present invention realizes the pre-filling and storage of microsphere dry powder reagent 5 through the sliding sealing cooperation between the dry powder pressure rod 1 and the sealing jacket 2. After connecting the plasma cup 3, the reagent can be dropped into the liquid simply by pressing down the dry powder pressure rod 1. Combined with the anti-slip texture 4 on the cup body, it is easy to shake slightly to accelerate mixing. Thus, the entire process from reagent sealing and storage to one-button release and mixing is completed with a simple and compact structure. The operation is simple and efficient and avoids pollution and waste.

[0033] Although embodiments of the present invention have been shown and described, these specific embodiments are merely explanations of the invention and are not intended to limit it. The specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. After reading this specification, those skilled in the art may make modifications, substitutions, and variations to the embodiments as needed without departing from the principles and spirit of the invention, but such modifications, substitutions, and variations are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. An automatic mixing device for pre-filled reagents, characterized in that, include: The dry powder pressure rod (1) has a push part at the upper end and a slotted hole at the lower end, with recesses symmetrically provided on both sides of the slotted hole; A sealing jacket (2) is fitted onto the outside of the dry powder press rod (1) and is sealed in the recess. The microsphere dry powder reagent (5) is pre-loaded into the cavity formed by the groove-shaped hole of the dry powder press rod (1) and sealed by the sealing jacket (2); The plasma cup (3) is a hollow cylindrical container whose opening is adapted to the sealing jacket (2) to form a sealed mixing cavity for containing liquid samples.

2. The pre-filled reagent automatic mixing device according to claim 1, characterized in that, The dry powder press rod (1) is a T-shaped column structure.

3. The pre-filled reagent automatic mixing device according to claim 1, characterized in that, The sealing jacket (2) is made of elastic sealing material, and its inner side is provided with a slide that is compatible with the dry powder pressure rod (1).

4. The pre-filled reagent automatic mixing device according to claim 3, characterized in that, The elastic sealing material is medical-grade rubber or medical-grade silicone.

5. The pre-filled reagent automatic mixing device according to claim 1, characterized in that, The plasma cup (3) is made of transparent medical plastic.

6. The pre-filled reagent automatic mixing device according to claim 1, characterized in that, The plasma cup (3) has anti-slip texture (4) on its cup wall.

7. The pre-filled reagent automatic mixing device according to claim 1, characterized in that, The microsphere dry powder reagent (5) is an activated carbon microsphere adsorbed with the reagent for detection.

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