Anesthesia depth monitoring device for anesthesia experiment
By designing a lever structure and linkage component for monitoring anesthesia depth without opening the induction chamber, the problem of unstable anesthetic gas environment caused by invasive operations was solved, thus ensuring the accuracy of experimental results and protecting the health of operators.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-30
- Publication Date
- 2026-04-10
AI Technical Summary
The existing technology involves manually turning over mice through invasive procedures, which leads to an unstable anesthetic gas environment, affects the accuracy of experimental results, and poses a threat to the health of operators.
Design an anesthesia depth monitoring device for anesthesia experiments. Utilizing a lever structure and linkage components, the device monitors the anesthesia depth through non-invasive flipping operations using the active movement of mice and the design of the lure without opening the induction box.
While maintaining a stable anesthetic gas environment, the accuracy of experimental results was improved, the health risks to operators were reduced, and the operating procedures were simplified.
Smart Images
Figure CN121817808A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of experimental equipment technology, and specifically to an anesthesia depth monitoring device for anesthesia experiments. Background Technology
[0002] Sevoflurane is a volatile inhaled anesthetic. Due to its significant advantages such as rapid induction, stable recovery, minimal airway irritation, and low metabolic rate, it has become the preferred drug in modern clinical and basic medical research, especially in animal experiments requiring precise control of anesthesia depth and duration (such as neuroscience, cardiovascular research, and long-duration surgical simulations). Its anesthetic effect is clearly concentration-dependent; different concentrations of sevoflurane can produce varying depths of anesthesia, ranging from sedation and loss of consciousness to surgical anesthesia.
[0003] In existing technologies, in routine laboratory settings lacking sophisticated neurophysiological monitoring equipment, the assessment of anesthesia depth in small laboratory animals such as mice primarily relies on simple and classic behavioral and physiological reflex tests, such as the righting reflex. The disappearance and recovery of the righting reflex are widely recognized as the most intuitive and reliable gold standard behavioral indicator for judging the transition of an animal's state of consciousness (i.e., from wakefulness to anesthesia, or the beginning of awakening from anesthesia). The principle is that when the integrative function of the animal's cerebral cortex is sufficiently inhibited by the anesthetic, it loses the basic ability to maintain a normal body position; when the anesthesia eases to the point that cortical function begins to recover, the animal will instinctively attempt to right itself from an unnatural supine or lateral position to a prone standing position.
[0004] During the experiment, the detection of the righting reflex relies heavily on manual intervention. For example, the experimenter must repeatedly open the hatch / door of the induction chamber or anesthesia maintenance device, inserting their hands or tools (such as tweezers or levers) into the anesthetic gas environment to directly contact or push the mouse to turn over. However, this invasive procedure connects the air inside and outside the induction chamber, disrupting the stable anesthetic gas environment inside and making it difficult to maintain the target anesthetic concentration, thus affecting the constancy of experimental conditions and the accuracy of results. Furthermore, high concentrations of sevoflurane gas diffuse directly into the laboratory air, posing a significant potential health threat to the operators with long-term exposure. Summary of the Invention
[0005] In view of this, the purpose of the present invention is to provide an anesthesia depth monitoring device for anesthesia experiments, so as to solve the problem that in the prior art, by manually turning the mouse over in the induction box, it is difficult to maintain the target anesthesia concentration in the box, which affects the accuracy of the experimental results.
[0006] This invention is achieved through the following technical solution: An anesthesia depth monitoring device for anesthesia experiments includes an induction chamber. A ventilation connector connecting the inner and outer sides is provided on the side wall of the induction chamber. A receiving platform extending along the length of the induction chamber is provided inside the induction chamber. The middle part of the receiving platform is rotatably connected to the induction chamber via a rotating shaft. The axis of the rotating shaft is parallel to the bottom wall of the induction chamber. Above the receiving platform is a hanging basket for holding mouse attractants, and a rotating frame for supporting the hanging basket is provided on the rotating shaft. The rotating frame and the rotating shaft are rotatably connected about the axis of the rotating shaft. A first linkage component is provided between the receiving platform and the rotating frame. When the receiving platform rotates inside the induction box, the first linkage component drives the rotating frame to rotate in the opposite direction.
[0007] Furthermore, the rotating frame is U-shaped, and the suspended basket is suspended and connected to the middle of the closed side of the rotating frame; Both ends of the rotating frame on the open side are rotatably engaged with the rotating shaft, and the middle part of the receiving platform is placed in the cavity formed by the rotating frame and the rotating shaft; A drive shaft coaxial with the rotating shaft is fixedly connected to the outer wall of one end of the rotating frame. The end of the drive shaft facing away from the rotating frame extends out of the guide box through the side wall of the guide box and is rotatably engaged.
[0008] Furthermore, one end of the rotating shaft is fixedly connected to the inner side wall of the induction box, and the other end extends along the width direction of the induction box and penetrates the bottom wall of the receiving platform to rotate with the receiving platform. The first linkage component includes a transmission gear whose axis is parallel to the axis of the rotating shaft, an outer gear ring and an inner gear ring that mesh with both ends of the transmission gear, and a boss is provided on the outer circular surface of the rotating shaft. The middle part of the transmission gear is rotatably engaged with the boss. The external gear ring is sleeved outside the rotating shaft and coaxial with the rotating shaft, and is fixedly installed on the outer wall of the receiving platform. The internal gear ring is sleeved outside the rotating shaft and coaxial with the rotating shaft, and is fixedly installed on the rotating frame.
[0009] Furthermore, the receiving platform has a hollow structure with an open top surface, and the bottom wall of the receiving platform is provided with upwardly protruding stirring bars.
[0010] Furthermore, each of the two side walls of the receiving platform along the width direction is provided with a strip-shaped hole extending in the length direction of the receiving platform, and the two ends of the mixing bar are respectively inserted into the two strip-shaped holes and slide in the length direction of the receiving platform. A second linkage component is provided between the mixing strip and the rotating frame. When the rotating frame rotates to one end near the receiving platform, the mixing strip slides on the receiving platform in the direction of that end near the receiving platform.
[0011] Furthermore, the end of the mixing bar extends out of the receiving platform through the strip-shaped hole, and the second linkage component includes a pull rope, one end of which is connected to the end of the mixing bar outside the receiving platform, and the other end is connected to the side of the rotating frame opposite to the rotating shaft. When the pull rope is taut, the straight line it lies in is perpendicular to the axis of the rotating shaft, and the distance from the connection point of the pull rope and the rotating frame to the axis of the rotating shaft is less than the length of the pull rope.
[0012] Furthermore, both ends of the pulling rope are fixedly connected to a rotating ring with an axis parallel to the axis of the rotating shaft. One of the rotating rings is rotatably connected to the rotating frame with the axis of the rotating ring as the center, and the other rotating ring is sleeved on the outside of the end of the mixing strip and is rotatably engaged.
[0013] Furthermore, two mixing bars are provided inside the receiving platform and are arranged along the length of the receiving platform; The two mixing bars are fixedly connected by a support rod, and a pull rope is provided between the two mixing bars and the rotating frame, and the two pull ropes are of the same length.
[0014] Furthermore, the distance between the two mixing bars is less than the length of the strip hole. When the rotating frame rotates to be perpendicular to the bottom wall of the receiving platform, and one of the mixing bars is located at one end of the strip hole, the pull rope corresponding to that mixing bar is stretched and tightened.
[0015] Furthermore, the induction box includes a box body with a hollow structure and an opening at the top, and a box cover for covering and sealing the opening at the top of the box body. The lid is detachably and fixedly connected to the box body, and the lid is provided with an observation window made of light-transmitting material.
[0016] The beneficial effects of this invention are as follows: This device for monitoring the depth of anesthesia in an anesthesia experiment utilizes a holding platform to hold experimental mice. The platform is rotated and mounted within an induction box, creating a lever structure. A basket is used to hold the mice as bait, allowing the mice to move actively on the platform. As the mice's footholds change, the platform rotates, altering its angle. The rotation of the platform provides feedback on the mice's movement, facilitating the observation and determination of the depth of anesthesia. As the rotation angle of the platform increases, the effort required by the mice to maintain their position or move towards the bait increases, resulting in more significant changes in their movement and making the observation and determination of the depth of anesthesia easier.
[0017] Simultaneously, the rotating frame and the receiving platform are connected by a first linkage component, causing them to rotate synchronously in opposite directions. That is, when the mouse is positioned at one end of the receiving platform, that end rotates and lowers, while the other end rotates and rises. This causes the mouse decoy on the rotating frame to rotate away from the mouse, attracting the mouse to move continuously along the length of the receiving platform. This device eliminates the need to open the induction chamber and allows for mouse repositioning without disrupting the internal anesthetic gas environment, thus improving the accuracy of experimental results.
[0018] Other advantages, objectives, and features of the invention will be set forth in part in the description which follows, and in part will be apparent to those skilled in the art from the following examination, or may be learned from practice of the invention. The objectives and other advantages of the invention can be realized and obtained through the following description. Attached Figure Description
[0019] Figure 1 This is a three-dimensional structural diagram of an embodiment of the present invention; Figure 2 This is a schematic diagram of the planar structure of an embodiment of the present invention; Figure 3 for Figure 2 Sectional view of AA; Figure 4 for Figure 3 A magnified view of a section at point B in the middle; Figure 5 This is an exploded view of an embodiment of the present invention; Figure 6 This is a three-dimensional structural diagram of the induction box in an embodiment of the present invention; Figure 7 This is a three-dimensional structural diagram of the receiving platform in an embodiment of the present invention; Figure 8 This is a three-dimensional structural diagram of the rotating frame in an embodiment of the present invention; Figure 9 This is a three-dimensional structural diagram of the mixing strip and the pulling rope in an embodiment of the present invention.
[0020] In the diagram: 1. Induction box; 11. Rotating shaft; 12. Boss; 13. Observation window; 2. Container platform; 21. Strip hole; 3. Hanging basket; 4. Rotating frame; 41. Drive shaft; 51. Drive gear; 52. External gear ring; 53. Internal gear ring; 6. Mixing bar; 61. Support rod; 7. Pulling rope. Detailed Implementation
[0021] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0022] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.
[0023] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.
[0024] In the above description of the present invention, it should be noted that the terms "one side," "the other side," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the invention is conventionally placed during use. These terms are used only for the convenience of describing the present invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.
[0025] Furthermore, terms such as "identical" do not imply that components must be absolutely identical; minor differences are permissible. The term "perpendicular" simply means that the positional relationship between components is more perpendicular than "parallel," not that the structure must be perfectly perpendicular; a slight tilt is acceptable.
[0026] Please see Figure 1-9 The present invention provides a technical solution: an anesthesia depth monitoring device for anesthesia experiments, including an induction box 1, wherein a ventilation connector connecting the inner and outer sides is provided on the side wall of the induction box 1, and a receiving platform 2 extending in the length direction of the induction box 1 is provided inside the induction box 1. The middle part of the receiving platform 2 is rotatably connected to the induction box 1 through a rotating shaft 11, and the axis of the rotating shaft 11 is parallel to the bottom wall of the induction box 1. Above the receiving platform 2 is a hanging basket 3 for holding mouse attractants. A rotating frame 4 for supporting the hanging basket 3 is provided on the rotating shaft 11. The rotating frame 4 and the rotating shaft 11 are rotatably connected about the axis of the rotating shaft 11. A first linkage component is provided between the receiving platform 2 and the rotating frame 4. When the receiving platform 2 rotates in the induction box 1, the first linkage component drives the rotating frame 4 to rotate in the opposite direction.
[0027] In this method, experimental mice are placed on a receiving platform 2. The platform 2 is rotated and installed inside an induction box 1, creating a lever structure. A hanging basket 3 holds the mouse bait, allowing the mice to move actively on the receiving platform 2. As the mice's footholds on the platform change, the platform 2 rotates, changing its angle. The rotation of the platform 2 provides feedback on the mice's movement, facilitating the observation and assessment of the depth of anesthesia. As the rotation angle of the receiving platform 2 increases, the effort required by the mice to maintain their position or move towards the bait increases, resulting in more significant changes in their movement and making it easier to observe and determine the depth of anesthesia.
[0028] Simultaneously, the rotating frame 4 and the receiving platform 2 are connected by a first linkage component, causing them to rotate synchronously in opposite directions. That is, when the mouse is located at one end of the receiving platform 2, that end rotates and lowers, while the other end rotates and rises. This causes the mouse lure on the rotating frame 4 to rotate away from the direction of the mouse, attracting the mouse to move continuously along the length of the receiving platform 2. This device eliminates the need to open the induction box 1 and allows for mouse repositioning without disrupting its internal anesthetic gas environment, thus improving the accuracy of experimental results.
[0029] The receiving platform 2 is symmetrically arranged at both ends along its length with the pivot 11 as the center. The difference in gravity between the two ends of the receiving platform 2 is minimized, and the pivot 11 supports the receiving platform 2, creating a relatively stable lever structure to facilitate the perception of changes in the mouse's stepping points on the receiving platform 2. Two limiting posts are arranged along the length of the bottom wall of the induction box 1, located on the rotational trajectory at both ends of the receiving platform 2. These posts limit the maximum tilt angle of the receiving platform 2, which is designed to allow the mouse to climb normally, enabling it to climb and cross over to the other end when at the bottom of the receiving platform 2.
[0030] Mouse attractants can be selected from foods that are highly attractive to mice, such as peanut butter, nut butter, sunflower seeds, and mouse feed chunks, which can attract mice to approach actively through their scent.
[0031] The vent connector serves as a channel for mass exchange, connecting to external equipment such as a sevoflurane vaporizer, medical oxygen, or a mixed gas source (e.g., O2 / N2O). Only through the vent connector is there connection to the outside, allowing the use of external equipment to create a relatively stable sevoflurane concentration environment inside the induction chamber 1. The methods and equipment for constructing this sevoflurane concentration environment are existing mature technologies, and therefore will not be elaborated upon here.
[0032] In this embodiment: the rotating frame 4 is U-shaped, and the hanging basket 3 is suspended and connected to the middle of the closed side of the rotating frame 4; Both ends of the open side of the rotating frame 4 are rotatably engaged with the rotating shaft 11, and the middle part of the receiving platform 2 is placed in the cavity formed by the rotating frame 4 and the rotating shaft 11; A transmission shaft 41, coaxial with the rotating shaft 11, is fixedly connected to the outer wall of one end of the rotating frame 4. The end of the transmission shaft 41 facing away from the rotating frame 4 extends out of the side wall of the induction box 1 and is rotatably engaged.
[0033] In this design, the basket 3 is suspended from the rotating frame 4 by a rope. Under the action of gravity, the basket 3 is always in an upward-facing position, which can effectively reduce the risk of mouse attractants spilling or falling out of the basket 3.
[0034] The rotating frame 4 is set outside the receiving platform 2 to reduce the risk of interference from the mice on the receiving platform 2 to the movement of the rotating frame 4. The open side frame of the rotating frame 4 covers the middle of the receiving platform 2, so that the hanging basket 3 on the closed side of the rotating frame 4 is always above the receiving platform 2, so as to facilitate the observation and perception of the mice.
[0035] Meanwhile, by extending the drive shaft 41 through the side wall of the induction chamber 1 and outside the induction chamber 1, the rotating frame 4 can be driven to rotate electrically or manually from outside the induction chamber 1. This, in turn, drives the receiving platform 2 to rotate via the first linkage component, changing the tilt angle of the receiving platform 2 and causing the mouse to roll over. That is, power can be input from outside the induction chamber 1 to make the device operate, increasing the mechanism of passive movement of the mouse. For example, when the mouse is stationary (without movement) at one end (bottom) of the receiving platform 2, the mouse can be lifted by manually rotating the drive shaft 41, changing the tilt direction of the receiving platform 2, causing the mouse to slide down the bottom wall of the receiving platform 2 towards the other end, causing the mouse to roll over. The depth of anesthesia can be determined by observing whether the mouse exhibits a righting reflex after reaching the other end.
[0036] In this embodiment: one end of the rotating shaft 11 is fixedly connected to the inner wall of the induction box 1, and the other end extends along the width direction of the induction box 1 and penetrates the bottom wall of the receiving platform 2 and rotates with the receiving platform 2. The first linkage component includes a transmission gear 51 whose axis is parallel to the axis of the rotating shaft 11, an outer gear ring 52 and an inner gear ring 53 that mesh with both ends of the transmission gear 51, and a boss 12 is provided on the outer circular surface of the rotating shaft 11. The middle part of the transmission gear 51 is rotatably engaged with the boss 12. The outer gear ring 52 is sleeved on the outside of the rotating shaft 11 and coaxial with the rotating shaft 11, and is fixedly installed on the outer side wall of the receiving platform 2. The inner gear ring 53 is sleeved on the outside of the rotating shaft 11 and coaxial with the rotating shaft 11, and is fixedly installed on the rotating frame 4.
[0037] In this design, the rotation of the rotating frame 4 and the receiving platform 2 is linked by a first linkage assembly consisting of a transmission gear 51, an external gear ring 52, and an internal gear ring 53, enabling them to rotate synchronously in opposite directions. This pure gear transmission method has the advantages of precise transmission, rapid response, and high synchronization, which helps to achieve a smooth flipping motion of the mouse and reduces the unexpected stimulation that may be caused to the mouse due to poor mechanical linkage.
[0038] The transmission gear 51 is located outside the outer gear ring 52, and the two mesh with each other to produce rotation in opposite directions; the transmission gear 51 is located inside the inner gear ring 53, and the two mesh with each other to produce rotation in the same direction (clockwise / counterclockwise). Therefore, the outer gear ring 52 and the inner gear ring 53 rotate in opposite directions.
[0039] In this embodiment: the receiving platform 2 has a hollow structure with an open top surface, and the bottom wall of the receiving platform 2 is provided with upwardly protruding mixing strips 6.
[0040] In this design, the opening size on the top surface of the receiving platform 2 is smaller than the size of the internal space of the receiving platform 2, so that the opening on the top surface of the receiving platform 2 tends to shrink inward, which increases the difficulty for mice to climb the side wall of the receiving platform 2 and reduces the risk of mice jumping over and running away.
[0041] The mixing strip 6 protrudes from the inner bottom wall surface of the receiving platform 2 and is used to restrict the mouse's torso from sliding downward along the bottom wall of the receiving platform 2. When an unanesthetized mouse slides to the position of the mixing strip 6, it can actively lift its legs to cross over, making its body relatively stable. When an anesthetized mouse or a mouse about to be anesthetized slides to the position of the mixing strip 6, it is difficult for it to control its legs to lift over the mixing strip 6. Under the blocking effect of the mixing strip 6, the probability of the mouse rolling over is increased.
[0042] In this embodiment: both sides of the receiving platform 2 along the width direction are provided with strip-shaped holes 21 extending in the length direction of the receiving platform 2, and the two ends of the mixing strip 6 are respectively inserted into the two strip-shaped holes 21 and slide in the length direction of the receiving platform 2. A second linkage component is provided between the mixing bar 6 and the rotating frame 4. When the rotating frame 4 rotates on the receiving platform 2 and one end is close to the receiving platform 2, the mixing bar 6 slides on the receiving platform 2 in the direction close to that end.
[0043] In this design, by sliding the mixing strip 6 to the receiving platform 2, the mechanism of action of the mixing strip 6 is changed from passive triggering (the mouse passively contacts and collides with the mixing strip 6) to active triggering (the mixing strip 6 and the mouse move towards each other and actively contact and collide). This shortens the collision triggering time. Furthermore, by providing the mixing strip 6 with a certain amount of kinetic energy, the interception resistance of the mixing strip 6 on the mouse's torso is increased.
[0044] The second linkage component drives the mixing strip 6 to move along the receiving platform 2. The moving mixing strip 6 can gently push the limbs or trunk of the mouse, more realistically simulating the "pushing" action during manual testing, making the triggering of the righting reflex more natural and effective, and reducing false negative results caused by improper stimulation methods.
[0045] In this embodiment: the end of the mixing bar 6 extends out of the receiving platform 2 through the strip hole 21. The second linkage component includes a pull rope 7. One end of the pull rope 7 is connected to the end of the mixing bar 6 outside the receiving platform 2, and the other end is connected to the side of the rotating frame 4 facing away from the rotating shaft 11. When the pull rope 7 is taut, the straight line it is in is perpendicular to the axis of the rotating shaft 11. The distance from the connection point of the pull rope 7 and the rotating frame 4 to the axis of the rotating shaft 11 is less than the length of the pull rope 7.
[0046] In this design, the pull rope 7 is used as the second linkage component. The pull rope 7 has a simple and reliable structure and is easy to adjust and maintain. Its direct connection method allows the motion of the rotating frame 4 to be efficiently converted into the linear motion of the mixing bar 6, with a clear linkage relationship. While realizing complex linkage functions, the mechanical structure is simplified to the maximum extent, reducing the processing and manufacturing cost of the device.
[0047] When the pull rope 7 is taut, its straight line is perpendicular to the axis of the rotating shaft 11, so that the plane of the movement trajectory of the pull rope 7 during the taut process is perpendicular to the rotating shaft 11. Furthermore, the pull rope 7 is connected to the mixing bar 6 at one end outside the receiving platform 2, which can avoid the position of the receiving platform 2 and reduce the interference of the receiving platform 2 on the transmission between the rotating frame 4 and the mixing bar 6.
[0048] A triangular structure is formed by the connection point of the pull rope 7 and the rotating frame 4 to the axis of the rotating shaft 11 (first side), the entire pull rope 7 (second side), and the section of the mixing bar 6 to the axis of the rotating shaft 11 (third side). The first and second sides are of fixed length. The length of the second side can be changed by rotating the rotating frame 4 to change the angle between the first and third sides, thereby causing the mixing bar 6 to slide within the strip-shaped hole 21.
[0049] In this embodiment: both ends of the pull rope 7 are fixedly connected to a rotating ring with an axis parallel to the axis of the rotating shaft 11. One of the rotating rings is rotatably connected to the rotating frame 4 with the axis of the rotating ring as the center, and the other rotating ring is sleeved on the outside of the end of the mixing strip 6 and rotates in cooperation with it.
[0050] In this design, swivels are installed at both ends of the pull rope 7 to reduce the risk of kinking and torsional stress that may occur during movement. This also reduces internal friction loss, extends the service life of the rope and related moving parts, and ensures the consistency of the linkage action in each flipping test.
[0051] Elastic support components such as coil springs can also be installed between the rotating ring and the rotating frame 4 / stirring bar 6 to provide rotational force to the rotating ring, so that the pulling rope 7 can be automatically retracted when the pulling rope 7 is not being pulled, thereby reducing the probability of the pulling rope 7 becoming loose and knotted.
[0052] In this embodiment: two mixing strips 6 are provided inside the receiving platform 2 and are arranged in the length direction of the receiving platform 2; The two mixing bars 6 are fixedly connected by a support rod 61. Each of the two mixing bars 6 is provided with a pull rope 7 between it and the rotating frame 4, and the two pull ropes 7 have the same length.
[0053] In this scheme, two mixing bars 6 (extending towards the width of the receiving platform 2) are fixedly connected together by a support rod 61 (extending towards the length of the receiving platform 2). Two pulling ropes 7 are used to pull the mixing bars 6 in two stages, namely, the mixing bars 6 move forward and backward in the strip hole 21, so that the mixing bars 6 can swing back and forth with the left and right of the receiving platform 2, and drive the mixing bars 6 to slide back and forth in the strip hole 21.
[0054] The dual-stirring bar design provides a larger contact area, expanding the contact range with the mouse's body and providing a more balanced and stable pushing force. Rigidly connected by the support rod 61, the two stirring bars 6 form a single motion unit, preventing the stirring bars 6 from jamming or moving asynchronously due to uneven force on a single pulling rope 7. This ensures smooth and synchronized pushing motions on the mouse, further enhancing the reliability and repeatability of the test.
[0055] In this embodiment: the distance between the two mixing bars 6 is less than the length of the strip hole 21. When the rotating frame 4 rotates to be perpendicular to the bottom wall of the receiving platform 2, and one of the mixing bars 6 is located at one end of the strip hole 21, the pulling rope 7 corresponding to the mixing bar 6 is stretched and tightened.
[0056] In this design, the two ends of the receiving platform 2 are defined as the left and right ends, respectively, with the two mixing bars 6 being the left mixing bar 6 and the right mixing bar 6. When the left mixing bar 6 is located at the left end of the strip-shaped hole 21, the rotating frame 4 can exhibit the following states as it rotates from the left side to the right side of the receiving platform 2: State 1: The receiving platform 2 is higher on the left and lower on the right, the rotating frame 4 is located on the far left, the left pull rope 7 is slack, and the right pull rope 7 is taut. State 2: The receiving platform 2 rotates (the left end gradually lowers while the right end component rises), and both the left and right pull ropes 7 are relaxed. State 3: Rotate the rotating frame 4 until it is perpendicular to the bottom wall of the receiving platform 2, with the left pull rope 7 taut and the right pull rope 7 slack. State 4: The receiving platform 2 is lower on the left and higher on the right. The rotating frame 4 is rotated to the far right. The left pull rope 7 is taut, the right pull rope 7 is slack, and the right mixing bar 6 is located at the right end of the strip hole 21.
[0057] After going through the above four states, move the mixing strip 6 from the left end to the right end of the receiving platform 2.
[0058] In this embodiment: the induction box 1 includes a box body with a hollow structure and an opening at the top and a box cover for covering and sealing the opening at the top of the box body; The lid is detachably and fixedly connected to the box body, and the lid is provided with an observation window 13 made of light-transmitting material.
[0059] In this solution, the cover can be fixed to the box body by means of bolt locking, and a sealing gasket is set between the two contact surfaces to make the inside of the induction box 1 a relatively sealed cavity.
[0060] The observation window 13 can be made of glass, which has high light transmittance. It allows the mouse's movement status inside the receiving table 2 to be observed through the observation window 13 from above the induction box 1, so as to help determine the depth of anesthesia of the mouse without opening the box lid for invasive operation.
[0061] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.
Claims
1. An anesthesia depth monitoring device for anesthesia experiments, comprising an induction chamber (1), wherein a ventilation connector communicating with the inner and outer sides is provided on the side wall of the induction chamber (1), characterized in that: The induction box (1) is provided with a receiving platform (2) extending in the length direction of the induction box (1). The middle part of the receiving platform (2) is rotatably connected to the induction box (1) through a rotating shaft (11). The axis of the rotating shaft (11) is parallel to the bottom wall of the induction box (1). Above the receiving platform (2) is a hanging basket (3) for holding mouse attractants. A rotating frame (4) for supporting the hanging basket (3) is provided on the rotating shaft (11). The rotating frame (4) and the rotating shaft (11) are rotatably connected about the axis of the rotating shaft (11). A first linkage component is provided between the receiving platform (2) and the rotating frame (4). When the receiving platform (2) rotates in the induction box (1), the rotating frame (4) is driven to rotate in the opposite direction through the first linkage component.
2. The anesthesia depth monitoring device for anesthesia experiments according to claim 1, characterized in that: The rotating frame (4) is U-shaped, and the basket (3) is suspended and connected to the middle of the closed side of the rotating frame (4); Both ends of the opening side of the rotating frame (4) are rotatably engaged with the rotating shaft (11), and the middle part of the receiving platform (2) is placed in the cavity formed by the rotating frame (4) and the rotating shaft (11); A transmission shaft (41) coaxial with the rotating shaft (11) is fixedly connected to the outer wall of one end of the rotating frame (4). The end of the transmission shaft (41) facing away from the rotating frame (4) extends out of the side wall of the induction box (1) and rotates in coordination.
3. The anesthesia depth monitoring device for anesthesia experiments according to claim 1, characterized in that: One end of the rotating shaft (11) is fixedly connected to the inner wall of the induction box (1), and the other end extends along the width direction of the induction box (1) and passes through the bottom wall of the receiving platform (2) and rotates with the receiving platform (2); The first linkage component includes a transmission gear (51) whose axis is parallel to the axis of the rotating shaft (11), an outer gear ring (52) and an inner gear ring (53) that mesh with both ends of the transmission gear (51), and a boss (12) is provided on the outer circular surface of the rotating shaft (11). The middle part of the transmission gear (51) is rotatably engaged with the boss (12). The outer gear ring (52) is sleeved on the outside of the rotating shaft (11) and coaxial with the rotating shaft (11), and is fixedly installed on the outer side wall of the receiving platform (2). The inner gear ring (53) is sleeved on the outside of the rotating shaft (11) and coaxial with the rotating shaft (11), and is fixedly installed on the rotating frame (4).
4. The anesthesia depth monitoring device for anesthesia experiments according to claim 1, characterized in that: The receiving platform (2) has a hollow structure with an open top surface, and the bottom wall of the receiving platform (2) is provided with upwardly protruding mixing strips (6).
5. The anesthesia depth monitoring device for anesthesia experiments according to claim 4, characterized in that: The receiving platform (2) has strip-shaped holes (21) extending in the length direction of the receiving platform (2) on both sides of its width direction. The two ends of the mixing strip (6) are respectively inserted into the two strip-shaped holes (21) and slide in the length direction of the receiving platform (2). A second linkage component is provided between the mixing bar (6) and the rotating frame (4). When the rotating frame (4) rotates on the receiving platform (2) to one end close to the receiving platform (2), the mixing bar (6) slides on the receiving platform (2) towards that end close to the receiving platform (2).
6. The anesthesia depth monitoring device for anesthesia experiments according to claim 5, characterized in that: The end of the mixing bar (6) extends out of the receiving platform (2) through the strip hole (21). The second linkage component includes a pull rope (7). One end of the pull rope (7) is connected to the end of the mixing bar (6) outside the receiving platform (2), and the other end is connected to the side of the rotating frame (4) facing away from the rotating shaft (11). When the traction rope (7) is taut, the straight line is perpendicular to the axis of the rotating shaft (11). The distance from the connection point of the traction rope (7) and the rotating frame (4) to the axis of the rotating shaft (11) is less than the length of the traction rope (7).
7. The anesthesia depth monitoring device for anesthesia experiments according to claim 6, characterized in that: Both ends of the pulling rope (7) are fixedly connected to a rotating ring whose axis is parallel to the axis of the rotating shaft (11). One of the rotating rings is rotatably connected to the rotating frame (4) with the axis of the rotating ring as the center, and the other rotating ring is sleeved on the outside of the end of the mixing strip (6) and rotates in conjunction with it.
8. The anesthesia depth monitoring device for anesthesia experiments according to claim 6, characterized in that: Two mixing strips (6) are provided inside the receiving platform (2) and are arranged along the length of the receiving platform (2); The two mixing bars (6) are fixedly connected by a support rod (61). Each of the two mixing bars (6) is provided with a pull rope (7) between it and the rotating frame (4), and the two pull ropes (7) have the same length.
9. The anesthesia depth monitoring device for anesthesia experiments according to claim 8, characterized in that: When the distance between the two mixing bars (6) is less than the length of the strip hole (21), the rotating frame (4) rotates to be perpendicular to the bottom wall of the receiving platform (2), and when one of the mixing bars (6) is located at one end of the strip hole (21), the pulling rope (7) corresponding to the mixing bar (6) is stretched and tightened.
10. The anesthesia depth monitoring device for anesthesia experiments according to claim 1, characterized in that: The induction box (1) includes a box body with a hollow structure and an opening at the top, and a box cover for covering and sealing the opening at the top of the box body. The lid is detachably and fixedly connected to the box body, and the lid is provided with an observation window (13) made of light-transmitting material.