Traditional Chinese medicine composition for improving blood lipid metabolism disorder and application thereof

Abstract

The invention relates to a traditional Chinese medicine composition for improving blood lipid metabolism disorder and application thereof. The traditional Chinese medicine composition for improving blood lipid metabolism disorder is prepared from the following traditional Chinese medicine components: rhizoma atractylodis macrocephalae, Chinese yam, herba cistanche, fructus amomi rotundus, radix salviae miltiorrhizae, raw radix et rhizoma rhei and radix glycyrrhizae preparata. According to the traditional Chinese medicine composition provided by the invention, the rhizoma atractylodis macrocephalae, the Chinese yam, the cistanche, the amomum cardamomum, the salvia miltiorrhiza, the raw rhubarb and the honey-fried licorice root are compatible, and all the components are mutually matched and have a synergistic effect, so that the traditional Chinese medicine composition has an excellent effect of improving the blood lipid metabolism disorder; specifically, the composition can improve the level of high-density lipoprotein in serum and / or reduce the level of low-density lipoprotein in serum, and the effects are obviously superior to those of a'spleen-tonifying and kidney-tonifying prescription '.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and relates to a traditional Chinese medicine composition for improving lipid metabolism disorders and its application. Background Technology

[0002] Lipid metabolism disorder refers to a pathological state in which abnormal levels of cholesterol, triglycerides, and lipoproteins in the blood are caused by an imbalance in the synthesis, breakdown, transport, or utilization of lipids. Its typical characteristics include elevated serum total cholesterol (TC) and / or low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C), or significantly elevated triglycerides (TG). This metabolic imbalance can be caused by a variety of factors, including genetic factors (such as familial hypercholesterolemia), unhealthy lifestyle (high-fat, high-sugar diets, lack of exercise), disease states (diabetes, hypothyroidism), or drug effects (such as glucocorticoids).

[0003] At the molecular level, dyslipidemia is often accompanied by increased activity of HMG-CoA reductase in the liver, promoting cholesterol synthesis; or decreased activity of lipoprotein lipase (LPL), leading to impaired triglyceride clearance. Pathologically, abnormally elevated LDL-C easily penetrates the vascular endothelium, and after oxidation, triggers macrophage phagocytosis to form foam cells, which deposit on the arterial wall to form atherosclerotic plaques. Conversely, decreased HDL-C levels weaken its reverse cholesterol transport function, further exacerbating lipid deposition. Clinically, dyslipidemia is not only a core risk factor for atherosclerotic cardiovascular disease but is also closely related to metabolic syndromes such as non-alcoholic fatty liver disease and insulin resistance. Early stages often present with no obvious symptoms, but abnormal indicators can be detected through blood biochemistry tests. Lifestyle interventions and drug treatments (such as statins and fibrates) are necessary to regulate lipid homeostasis.

[0004] Currently, the treatment of hyperlipidemia focuses more on inhibiting the synthesis of low-density lipoprotein, and there is less emphasis on comprehensive conditioning with traditional Chinese medicine prescriptions. Therefore, it is very meaningful to develop more traditional Chinese medicine prescriptions that have good efficacy, high safety and can specifically improve lipid metabolism disorders. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide a traditional Chinese medicine composition for improving lipid metabolism disorders and its application.

[0006] To achieve this objective, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides a traditional Chinese medicine composition for improving lipid metabolism disorders, wherein the traditional Chinese medicine components in the composition are composed of Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, Rheum palmatum, and Glycyrrhiza uralensis.

[0008] The traditional Chinese medicine composition involved in this invention is a "Formula without Astragalus" from the "Spleen-Strengthening and Kidney-Nourishing Formula" (Astragalus membranaceus, Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, Rheum palmatum, and Glycyrrhiza uralensis). In this formula, Atractylodes macrocephala and Dioscorea opposita tonify the spleen and stomach, while Cistanche deserticola tonifies the kidneys. Salvia miltiorrhiza nourishes and invigorates the blood, thus simultaneously tonifying the spleen and kidneys, replenishing qi and blood, and ensuring proper metabolism and elimination of turbidity. Amomum villosum resolves dampness and promotes qi circulation, while Rheum palmatum eliminates turbidity downwards, and Glycyrrhiza uralensis harmonizes the effects of the other herbs. This invention unexpectedly discovered that this "Formula without Astragalus" has excellent effects in improving lipid metabolism disorders, specifically by increasing the level of high-density lipoprotein in serum and / or decreasing the level of low-density lipoprotein in serum, and these effects are significantly superior to those of the "Spleen-Strengthening and Kidney-Nourishing Formula".

[0009] Preferably, the traditional Chinese medicine components in the herbal composition for improving lipid metabolism disorders are composed of 7-9 parts of Atractylodes macrocephala, 11-13 parts of Dioscorea opposita, 3-5 parts of Cistanche deserticola, 3-5 parts of Amomum villosum, 11-13 parts of Salvia miltiorrhiza, 1-3 parts of raw rhubarb, and 1-3 parts of prepared licorice root by mass.

[0010] When the various Chinese herbal components in the Chinese herbal composition are combined in the above-mentioned specific mass proportions, they have a better technical effect in improving lipid metabolism disorders.

[0011] In this invention, the proportions of Atractylodes macrocephala can be 7.2, 7.5, 7.8, 8, 8.2, 8.5, 8.8, etc.; the proportions of Dioscorea opposita can be 11.2, 11.5, 11.8, 12, 12.2, 12.5, 12.8, etc.; the proportions of Cistanche deserticola can be 3.2, 3.5, 3.8, 4, 4.2, 4.5, 4.8, etc.; and the proportions of Amomum villosum can be 3.2, 3.5, etc. 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, etc.; the number of parts of Salvia miltiorrhiza can be 11.2 parts, 11.5 parts, 11.8 parts, 12 parts, 12.2 parts, 12.5 parts, 12.8 parts, etc.; the number of parts of raw rhubarb can be 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, etc.; the number of parts of prepared licorice root can be 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, etc. Other specific values ​​not listed above within the above ranges can be selected, and will not be elaborated further here.

[0012] In this invention, the traditional Chinese medicine composition increases the level of high-density lipoprotein in serum.

[0013] In this invention, the traditional Chinese medicine composition reduces the level of low-density lipoprotein in serum.

[0014] Preferably, the traditional Chinese medicine composition is prepared by a method comprising the following steps:

[0015] The following herbs were pulverized into fine powder: Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, raw rhubarb, and prepared licorice root. The powders were then mixed evenly to obtain a traditional Chinese medicine composition.

[0016] Preferably, the traditional Chinese medicine composition further includes pharmaceutically acceptable excipients.

[0017] Preferably, the excipients include any one or a combination of at least two of the following: solvent, solubilizer, co-solvent, colorant, binder, disintegrant, filler, lubricant, wetting agent, osmotic pressure regulator, stabilizer, flow aid, flavoring agent, preservative, suspending agent, coating material, and fragrance.

[0018] Preferably, the dosage form of the traditional Chinese medicine composition includes decoction, pill, powder, paste, and elixir.

[0019] In a second aspect, the present invention provides the use of the traditional Chinese medicine composition described in the first aspect in the preparation of a medicament for the prevention, relief or treatment of hyperlipidemia.

[0020] Thirdly, the present invention provides the use of the traditional Chinese medicine composition described in the first aspect in the preparation of a drug for improving lipid metabolism disorders.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] The traditional Chinese medicine composition provided by this invention combines Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, raw rhubarb, and prepared licorice root. The components work together and enhance each other's effects, resulting in excellent effects in improving lipid metabolism disorders. Specifically, it can increase the level of high-density lipoprotein in serum and / or decrease the level of low-density lipoprotein in serum, and the above effects are significantly better than those of "Spleen-Strengthening and Kidney-Nourishing Formula". Detailed Implementation

[0023] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0024] The Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, raw rhubarb, and prepared licorice root used in the following examples were all provided by the pharmacy of Shenzhen Traditional Chinese Medicine Hospital.

[0025] Example

[0026] This embodiment provides a traditional Chinese medicine composition, which, by weight, consists of 8 parts Atractylodes macrocephala, 12 parts Dioscorea opposita, 4 parts Cistanche deserticola, 4 parts Amomum villosum, 12 parts Salvia miltiorrhiza, 2 parts raw rhubarb, and 2 parts prepared licorice root. The above raw materials are pulverized into a fine powder and mixed evenly to obtain the traditional Chinese medicine composition.

[0027] Comparative Example

[0028] This comparative example provides a traditional Chinese medicine composition, namely "Spleen-Strengthening and Kidney-Nourishing Formula," which, by weight, consists of 12 parts Astragalus membranaceus, 8 parts Atractylodes macrocephala, 12 parts Dioscorea opposita, 4 parts Cistanche deserticola, 4 parts Amomum villosum, 12 parts Salvia miltiorrhiza, 2 parts Rheum palmatum, and 2 parts Glycyrrhiza uralensis. The above raw materials are pulverized into a fine powder, mixed evenly, to obtain the traditional Chinese medicine composition.

[0029] Test case

[0030] Verification of the efficacy of traditional Chinese medicine composition in improving lipid metabolism disorders:

[0031] (1) Animal rearing conditions: Male Spraque-Dawley (SD) rats, weighing 180-220g, were purchased from Vital Rivers. The room temperature was controlled at 21℃±2℃, the relative humidity was controlled at 50%±15%, and the light cycle was 12 hours. The SD rats were acclimatized for 1 week and had free access to food and water.

[0032] (2) Experimental drugs: 1% Chinese medicine composition feed was obtained by mixing the Chinese medicine composition provided in the examples or comparative examples with rat maintenance feed at a mass ratio of 1:99; 0.75% adenine feed was obtained by mixing adenine granules with rat maintenance feed at a mass ratio of 0.75:99.25.

[0033] (3) Establishment and grouping of animal models: After 1 week of adaptive feeding, the rats were divided into 4 groups of 8 rats each: normal group, model group, example group (denoted as JPYS-HQ group), and control group (denoted as JPYS group). The rats in the normal group were fed a normal rat maintenance diet, while the rats in the model group, example group, and control group were fed a diet containing 0.75% adenine for 3 weeks to induce lipid metabolism disorders in the rats. After successful modeling, the example group was fed a diet containing 1% of the example traditional Chinese medicine composition every day, the control group was fed a diet containing 1% of the control traditional Chinese medicine composition every day, and the normal group and model group were fed an equal amount of rat maintenance diet. Samples were collected after 4 weeks of feeding.

[0034] (4) Sample collection: After anesthetizing the rats, they were fixed on the operating table. A midline incision was made in the abdomen to open the abdominal cavity and blood was collected from the abdominal aorta. After standing at room temperature for 2 hours, the blood was centrifuged at 3000 rpm for 10 minutes at 4℃ to collect the serum.

[0035] (5) Index determination: The content of high-density lipoprotein and low-density lipoprotein in rat serum was determined using a kit.

[0036] (6) Test results: The results are shown in Table 1.

[0037] Table 1

[0038]

[0039] The data in Table 1 show that higher levels of low-density lipoprotein (LDL) increase the likelihood of deposition on the blood vessel walls, leading to disease. Compared to the normal group, the serum LDL levels in the model group rats were significantly elevated, indicating lipid dysregulation. High-density lipoprotein (HDL) levels also showed a stress-induced increase. Intervention with the herbal compositions described in the examples or comparative studies significantly reduced LDL levels, effectively decreasing the risk of lipid deposition. The effects of the JPYS group were weaker than those of the JPYS-HQ group. Simultaneously, HDL levels were increased, enhancing the positive regulation of lipid health. The positive regulation was comparable between the JPYS and JPYS-HQ groups. This demonstrates that the herbal compositions involved in this invention are superior in reducing harmful LDL, providing a more comprehensive and significant regulation of lipid metabolism disorders, better restoring lipid homeostasis, and reducing the risk of cardiovascular disease.

[0040] The applicant declares that the technical solution of this invention is illustrated by the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of raw materials for the products of this invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of this invention.

[0041] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0042] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A traditional Chinese medicine composition for improving lipid metabolism disorders, characterized in that, The traditional Chinese medicine composition for improving lipid metabolism disorders consists of Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, Rheum palmatum, and Glycyrrhiza uralensis.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition for improving lipid metabolism disorders consists of the following components by mass: 7-9 parts of Atractylodes macrocephala, 11-13 parts of Dioscorea opposita, 3-5 parts of Cistanche deserticola, 3-5 parts of Amomum villosum, 11-13 parts of Salvia miltiorrhiza, 1-3 parts of raw rhubarb, and 1-3 parts of prepared licorice root.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The traditional Chinese medicine composition increases the level of high-density lipoprotein in serum.

4. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The traditional Chinese medicine composition reduces the level of low-density lipoprotein in serum.

5. The traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The traditional Chinese medicine composition is prepared by the following method: The following herbs were pulverized into fine powder: Atractylodes macrocephala, Dioscorea opposita, Cistanche deserticola, Amomum villosum, Salvia miltiorrhiza, raw rhubarb, and prepared licorice root. The powders were then mixed evenly to obtain a traditional Chinese medicine composition.

6. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition also includes pharmaceutically acceptable excipients.

7. The traditional Chinese medicine composition according to claim 6, characterized in that, The excipients include any one or a combination of at least two of the following: solvent, solubilizer, cosolvent, colorant, binder, disintegrant, filler, lubricant, wetting agent, osmotic pressure regulator, stabilizer, flow aid, flavoring agent, preservative, suspending agent, coating material, and fragrance.

8. The traditional Chinese medicine composition according to claim 1, characterized in that, The dosage forms of the traditional Chinese medicine composition include decoctions, pills, powders, ointments, and elixirs.

9. The use of the traditional Chinese medicine composition according to any one of claims 1-8 in the preparation of a medicament for the prevention, relief or treatment of hyperlipidemia.

10. The use of the traditional Chinese medicine composition according to any one of claims 1-8 in the preparation of a medicament for improving lipid metabolism disorders.

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