Brain glioma virus slow-release injection device

Abstract

The invention relates to the technical field of medical instruments, and discloses a brain glioma virus slow-release injection device which comprises a slow-release injection cylinder, a sliding cavity is formed in the slow-release injection cylinder, the left side face of the slow-release injection cylinder is communicated with a conical cover, the left side face of the conical cover is communicated with an injection pipe, and the injection pipe is communicated with a sliding cavity. And the left side surface of the injection tube is communicated with a conical injection head. According to the brain glioma virus slow-release injection device, a slow-release control device is arranged, an annular handle is used for driving an annular rotating plate to rotate, a rotating screw rod is driven to rotate through meshing transmission of a fixed rack and a rotating gear, then a vertical sliding block is driven to slide along a guide sliding rod, and a pressing transverse block is driven to move up and down through a linkage rod and a linkage support; the extrusion degree of the injection tube is adjusted, so that the release rate of a virus preparation is accurately controlled, flexible adjustment can be achieved according to the tumor condition of a patient, individualized treatment requirements are met, and the problem that the release rate of an existing device cannot be adjusted is solved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a sustained-release injection device for glioma virus. Background Technology

[0002] Gliomas are the most common primary malignant tumors of the central nervous system, characterized by high invasiveness, high recurrence rate, and poor prognosis. Currently, the main treatments for gliomas include surgical resection, radiotherapy, and chemotherapy. However, these traditional treatments are difficult to completely eliminate tumor cells, resulting in limited therapeutic effects. Existing injection devices for virus delivery are mostly conventional syringes, which can only achieve single-dose injections of the virus. Existing injection devices cannot achieve continuous and stable release of the virus, resulting in low delivery accuracy and an inability to adjust the release rate according to actual conditions. This makes it difficult to achieve sustained-release injection of the virus, reducing the convenience of use for users. Summary of the Invention

[0003] (a) Technical problems to be solved To address the shortcomings of existing technologies, this invention provides a sustained-release injection device for glioma virus, which solves the problems mentioned in the background section.

[0004] (II) Technical Solution To achieve the above objectives, the present invention provides the following technical solution: a glioblastoma virus sustained-release injection device, comprising a sustained-release injection cylinder, wherein a sliding cavity is provided inside the sustained-release injection cylinder, a conical cover is connected to the left side of the sustained-release injection cylinder, an injection tube is connected to the left side of the conical cover, a conical injection head is connected to the left side of the injection tube, a sustained-release control device is provided on the left side of the conical cover, a compression stabilizing device is provided on the right side of the outer surface of the sustained-release injection cylinder, a rotatable annular rotating plate is provided on the outer side of the sustained-release control device, a fixing rack is fixedly installed on the inner wall of the annular rotating plate, and an annular handle is fixedly installed on the outer surface of the annular rotating plate.

[0005] Preferably, a slidable sliding piston is provided inside the sliding cavity, a sliding crossbar is fixedly installed on the right side of the sliding piston, and a pressure sensor is fixedly installed on the right side of the slow-release syringe.

[0006] Preferably, the slow-release control device includes a stabilizing horizontal column fixedly installed on the left side of the conical cover. An L-shaped guide plate is fixedly installed on the left side of the stabilizing horizontal column. An auxiliary horizontal bar is fixedly installed on the outer surface of the stabilizing horizontal column. A vertical guide plate is fixedly installed on the left side of the auxiliary horizontal bar. A rotatable rotating screw is provided on the inner side of both the L-shaped guide plate and the vertical guide plate. A rotating gear is fixedly installed on the left side of the outer surface of the rotating screw. A fixed rack meshes with the rotating gear. An L-shaped positioning plate is fixedly installed on the right side of the vertical guide plate. A guide slide rod connected to the left side of the L-shaped guide plate is fixedly installed on the right side of the L-shaped positioning plate. A slidable vertical slider is provided on the outer surface of the guide slide rod. A movable bracket is fixedly installed on the lower surface of the vertical slider. A rotatable linkage rod is provided at the bottom of the movable bracket. A rotatable linkage bracket is provided at the bottom of the linkage rod. A pressing horizontal block is fixedly installed on the lower surface of the linkage bracket. A telescopic rod connected to the lower surface of the L-shaped positioning plate is fixedly installed on the left side of the pressing horizontal block.

[0007] Preferably, the extrusion stabilizing device includes a stabilizing vertical plate fixedly installed on the right side of the sliding cross column, a motor fixing plate fixedly installed on the right side of the stabilizing vertical plate, a drive motor fixedly installed on the outer side of the motor fixing plate, a drive screw fixedly installed at the output end of the drive motor, and a stabilizing block connected to the outer surface of the sustained-release injection cylinder is provided on the left side of the outer surface of the drive screw.

[0008] Preferably, both the L-shaped guide plate and the vertical guide plate have annular grooves on their inner sides, and the annular rotating plate slides along the annular grooves.

[0009] Preferably, the top of the vertical slider is provided with a threaded through hole, which is threadedly connected to the rotating screw.

[0010] Preferably, the stabilizer block has a drive threaded hole inside, which is threadedly connected to the drive screw.

[0011] Preferably, the outer surface of the ring handle is provided with an anti-slip layer, and the outer surface of the anti-slip layer is uniformly provided with anti-slip texture.

[0012] (III) Beneficial Effects Compared with the prior art, the present invention provides a sustained-release injection device for glioma virus, which has the following beneficial effects: 1. This glioblastoma virus sustained-release injection device, through the setting of a sustained-release control device, uses a ring handle to drive the ring rotating plate to rotate. Through the meshing transmission of a fixed rack and a rotating gear, the rotating screw is driven to rotate, which in turn drives the vertical slider to slide along the guide rail. Through the linkage rod and linkage bracket, the pressing block is moved up and down, realizing the adjustment of the squeezing degree of the injection tube, thereby precisely controlling the release rate of the viral agent. It can be flexibly adjusted according to the patient's tumor condition to adapt to individualized treatment needs, solving the problem of the non-adjustable release rate of existing devices.

[0013] 2. This gliovirus sustained-release injection device, through the setting of a compression stabilizing device and the use of a drive motor, combined with the threaded transmission of the drive screw and the stabilizing block, provides a smooth and uniform thrust to the sliding piston, avoiding injection speed fluctuations caused by manual operation, ensuring continuous and stable release of the viral preparation, maintaining an effective therapeutic concentration in the body, accurately controlling the injection dose, improving delivery accuracy, and reducing the risk of adverse reactions caused by operational errors.

[0014] 3. This gliovirus sustained-release injection device uses a pressure sensor to monitor pressure changes in the sliding cavity in real time and feeds the signal back to the main controller. The main controller automatically adjusts the speed of the drive motor based on the pressure data to ensure that the injection pressure is stable within a safe range. This avoids damage to brain tissue or impaired activity of the viral preparation due to excessive pressure, or reduced release effect due to insufficient pressure, thus further improving the safety and reliability of the injection process. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of a gliovirus sustained-release injection device proposed in this invention. Figure 2 This is a vertical cross-sectional schematic diagram of a gliovirus sustained-release injection device proposed in this invention. Figure 3 This is a side view of a gliovirus sustained-release injection device proposed in this invention. Figure 4 This is a partial structural schematic diagram of a gliovirus sustained-release injection device proposed in this invention. Figure 5 This is a schematic diagram of the structure of a sustained-release control device for a gliovirus sustained-release injection device proposed in this invention. Figure 6 This is a schematic diagram of the compression stabilization device structure of a gliovirus sustained-release injection device proposed in this invention.

[0016] In the diagram: 1. Sustained-release syringe; 2. Sliding cavity; 3. Conical hood; 4. Injection tube; 5. Conical injection head; 6. Sustained-release control device; 601. Stabilizing crossbar; 602. L-shaped guide plate; 603. Auxiliary crossbar; 604. Vertical guide plate; 605. Rotating screw; 606. Rotating gear; 607. L-shaped positioning plate; 608. Guide slide bar; 609. Vertical slider; 610. Moving bracket; 611. Linkage rod; 612. Linkage bracket; 613. Pressing crossbar; 614. Telescopic rod; 7. Extrusion stabilizing device; 701. Stabilizing vertical plate; 702. Motor fixing plate; 703. Drive motor; 704. Drive screw; 705. Stabilizing block; 8. Annular rotating plate; 9. Fixed rack; 10. Annular handle; 11. Sliding piston; 12. Sliding crossbar; 13. Pressure sensor. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Please see Figures 1-6 The present invention provides a technical solution: a glioblastoma virus sustained-release injection device, comprising a sustained-release injection cylinder 1, a sliding cavity 2 disposed inside the sustained-release injection cylinder 1, a conical cover 3 connected to the left side of the sustained-release injection cylinder 1, an injection tube 4 connected to the left side of the conical cover 3, a conical injection head 5 connected to the left side of the injection tube 4, a sustained-release control device 6 disposed on the left side of the conical cover 3, a compression stabilizing device 7 disposed on the right side of the outer surface of the sustained-release injection cylinder 1, a rotatable annular rotating plate 8 disposed on the outer side of the sustained-release control device 6, a fixed rack 9 fixedly installed on the inner wall of the annular rotating plate 8, an annular handle 10 fixedly installed on the outer surface of the annular rotating plate 8, a slidable sliding piston 11 disposed inside the sliding cavity 2, a sliding crossbar 12 fixedly installed on the right side of the sliding piston 11, and a pressure sensor 13 fixedly installed on the right side of the sustained-release injection cylinder 1.

[0019] In this invention, to achieve better sustained-release control, the sustained-release control device 6 includes a stabilizing horizontal column 601 fixedly installed on the left side of the conical cover 3. An L-shaped guide plate 602 is fixedly installed on the left side of the stabilizing horizontal column 601. An auxiliary horizontal bar 603 is fixedly installed on the outer surface of the stabilizing horizontal column 601. A vertical guide plate 604 is fixedly installed on the left side of the auxiliary horizontal bar 603. A rotatable rotating screw 605 is provided on the inner side of both the L-shaped guide plate 602 and the vertical guide plate 604. A rotating gear 606 is fixedly installed on the left side of the outer surface of the rotating screw 605. A fixed rack 9 meshes with the rotating gear 606. The right side of the vertical guide plate 604 is fixed... An L-shaped positioning plate 607 is installed. A guide slide rod 608 connected to the left side of an L-shaped guide plate 602 is fixedly installed on the right side of the L-shaped positioning plate 607. A slidable vertical slider 609 is provided on the outer surface of the guide slide rod 608. A movable bracket 610 is fixedly installed on the lower surface of the vertical slider 609. A rotatable linkage rod 611 is provided at the bottom of the movable bracket 610. A rotatable linkage bracket 612 is provided at the bottom of the linkage rod 611. A pressing cross block 613 is fixedly installed on the lower surface of the linkage bracket 612. A telescopic rod 614 connected to the lower surface of the L-shaped positioning plate 607 is fixedly installed on the left side of the pressing cross block 613.

[0020] In order to improve the stability of sustained release, the compression stabilizing device 7 includes a stabilizing vertical plate 701 fixedly installed on the right side of the sliding horizontal column 12. A motor fixing plate 702 is fixedly installed on the right side of the stabilizing vertical plate 701. A drive motor 703 is fixedly installed on the outer side of the motor fixing plate 702. A drive screw 704 is fixedly installed at the output end of the drive motor 703. A stabilizing block 705 connected to the outer surface of the sustained release injection cylinder 1 is provided on the left side of the outer surface of the drive screw 704.

[0021] In order to facilitate more stable rotation, the inner sides of the L-shaped guide plate 602 and the vertical guide plate 604 are provided with annular grooves, and the annular rotating plate 8 slides along the annular grooves.

[0022] In order to facilitate stable movement, a threaded through hole is provided at the top of the vertical slider 609, and the threaded through hole is threadedly connected to the rotating screw 605.

[0023] In order to improve the stability of the drive, the inside of the stabilizing block 705 is provided with a drive threaded hole, which is threadedly connected to the drive screw 704.

[0024] In this invention, to improve the anti-slip effect, an anti-slip layer is provided on the outer surface of the annular handle 10, and anti-slip textures are uniformly provided on the outer surface of the anti-slip layer. All electrical components mentioned in this article are connected to an external main controller and 220V AC mains power, and the main controller can be a conventional known device such as a computer that can control it.

[0025] During use, based on the patient's tumor size, location, and condition, and under imaging guidance, the cone-shaped injection head 5 is precisely punctured into the glioma lesion site, ensuring the injection head is located inside the tumor tissue or in the target area. The injection tube 4 is fixed to prevent displacement of the puncture site. Depending on the local tumor condition, the sustained-release control device 6 is adjusted. Holding the ring handle 10, the ring rotating plate 8 is rotated clockwise, causing the fixed rack 9 to rotate, which in turn drives the rotating gear 606 and rotating screw 605 to rotate. The vertical slider 609 slides along the guide slide rod 608, pushing the pressing block 613 towards the injection tube 4 via the linkage rod 611 and linkage bracket 612, increasing the pressure on the injection tube 4, reducing the lumen cross-sectional area, and decreasing the release rate. Rotating the ring handle 10 counterclockwise moves the pressing block 613 upwards, decreasing the pressure and increasing the release rate, until the set release rate is achieved. To ensure the pressure remains stable within a safe range, after the slow-release adjustment is completed, the drive motor 703 is started and operates at the set speed, driving the drive screw 704 to rotate. Since the drive screw 704 is threadedly connected to the stabilizing block 705, the drive motor 703, motor fixing plate 702, stabilizing vertical plate 701, and sliding horizontal column 12 move to the left as a whole, pushing the sliding piston 11 to slide slowly to the left along the sliding cavity 2, uniformly pushing the viral preparation into the injection tube 4. During the injection process, the pressure sensor 13 monitors the pressure changes in the sliding cavity 2 in real time. If the pressure exceeds the set threshold, the speed of the drive motor 703 is automatically reduced until the pressure returns to a safe range. If the pressure is lower than the set threshold, the speed of the drive motor 703 is automatically increased to ensure stable injection pressure. At the same time, medical staff can observe the patient's lesion area and the device's operating status in real time through imaging equipment, and deal with any abnormalities in a timely manner.

[0026] In summary, this glioma virus sustained-release injection device, by setting a sustained-release control device 6, uses an annular handle 10 to drive the annular rotating plate 8 to rotate. Through the meshing transmission between the fixed rack 9 and the rotating gear 606, the rotating screw 605 is driven to rotate, which in turn drives the vertical slider 609 to slide along the guide slide rod 608. Through the linkage rod 611 and the linkage bracket 612, the pressing block 613 is moved up and down, thereby adjusting the degree of compression of the injection tube 4. This allows for precise control of the release rate of the viral agent, which can be flexibly adjusted according to the patient's tumor condition to meet individualized treatment needs, thus solving the problem of the non-adjustable release rate of existing devices.

[0027] This gliovirus sustained-release injection device, through the setting of a compression stabilizing device 7, is driven by a drive motor 703, and in conjunction with the threaded transmission of the drive screw 704 and the stabilizing block 705, provides a smooth and uniform thrust to the sliding piston 11, avoiding injection speed fluctuations caused by manual operation, ensuring continuous and stable release of the viral preparation, maintaining an effective therapeutic concentration in the body, accurately controlling the injection dose, improving delivery accuracy, and reducing the risk of adverse reactions caused by operational errors.

[0028] This gliovirus sustained-release injection device uses a pressure sensor 13 to monitor pressure changes in the sliding cavity 2 in real time and feeds the signal back to the main controller. The main controller automatically adjusts the speed of the drive motor 703 based on the pressure data to ensure that the injection pressure is stable within a safe range. This avoids damage to brain tissue or impaired activity of the viral preparation due to excessive pressure, or reduced release effect due to insufficient pressure, thus further improving the safety and reliability of the injection process.

[0029] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sustained-release injection device for glioma virus, comprising a sustained-release injection cylinder (1), wherein a sliding cavity (2) is provided inside the sustained-release injection cylinder (1), a conical cover (3) is connected to the left side of the sustained-release injection cylinder (1), an injection tube (4) is connected to the left side of the conical cover (3), and a conical injection head (5) is connected to the left side of the injection tube (4), characterized in that: The left side of the conical cover (3) is provided with a slow-release control device (6), the right side of the outer surface of the slow-release injection cylinder (1) is provided with a squeezing stabilizing device (7), the outer side of the slow-release control device (6) is provided with a rotatable annular rotating plate (8), the inner wall of the annular rotating plate (8) is fixedly installed with a fixing rack (9), and the outer surface of the annular rotating plate (8) is fixedly installed with an annular handle (10).

2. The gliovirus sustained-release injection device according to claim 1, characterized in that: The sliding cavity (2) is provided with a sliding piston (11), a sliding crossbar (12) is fixedly installed on the right side of the sliding piston (11), and a pressure sensor (13) is fixedly installed on the right side of the slow-release syringe (1).

3. The gliovirus sustained-release injection device according to claim 1, characterized in that: The slow-release control device (6) includes a stabilizing horizontal column (601) fixedly installed on the left side of the conical cover (3), an L-shaped guide plate (602) fixedly installed on the left side of the stabilizing horizontal column (601), an auxiliary horizontal bar (603) fixedly installed on the outer surface of the stabilizing horizontal column (601), a vertical guide plate (604) fixedly installed on the left side of the auxiliary horizontal bar (603), a rotatable rotating screw (605) provided on the inner side of both the L-shaped guide plate (602) and the vertical guide plate (604), a rotating gear (606) fixedly installed on the left side of the outer surface of the rotating screw (605), a fixed rack (9) meshing with the rotating gear (606), and an L-shaped positioning plate fixedly installed on the right side of the vertical guide plate (604). 607), the right side of the L-shaped positioning plate (607) is fixedly installed with a guide slide rod (608) connected to the left side of the L-shaped guide plate (602). The outer surface of the guide slide rod (608) is provided with a slidable vertical slider (609). The lower surface of the vertical slider (609) is fixedly installed with a movable bracket (610). The bottom of the movable bracket (610) is provided with a rotatable linkage rod (611). The bottom of the linkage rod (611) is provided with a rotatable linkage bracket (612). The lower surface of the linkage bracket (612) is fixedly installed with a pressing cross block (613). The left side of the pressing cross block (613) is fixedly installed with a telescopic rod (614) connected to the lower surface of the L-shaped positioning plate (607).

4. The gliovirus sustained-release injection device according to claim 1, characterized in that: The compression stabilizing device (7) includes a stabilizing vertical plate (701) fixedly installed on the right side of the sliding horizontal column (12), a motor fixing plate (702) fixedly installed on the right side of the stabilizing vertical plate (701), a drive motor (703) fixedly installed on the outer side of the motor fixing plate (702), a drive screw (704) fixedly installed at the output end of the drive motor (703), and a stabilizing block (705) connected to the outer surface of the sustained-release injection cylinder (1) is provided on the left side of the outer surface of the drive screw (704).

5. The gliovirus sustained-release injection device according to claim 3, characterized in that: The inner sides of the L-shaped guide plate (602) and the vertical guide plate (604) are provided with annular grooves, and the annular rotating plate (8) slides along the annular grooves.

6. The gliovirus sustained-release injection device according to claim 3, characterized in that: The top of the vertical slider (609) is provided with a threaded through hole, which is threadedly connected to the rotating screw (605).

7. The gliovirus sustained-release injection device according to claim 4, characterized in that: The stabilizer block (705) has a drive threaded hole inside, which is threadedly connected to the drive screw (704).

8. The gliovirus sustained-release injection device according to claim 1, characterized in that: The outer surface of the ring handle (10) is provided with an anti-slip layer, and the outer surface of the anti-slip layer is uniformly provided with anti-slip texture.

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