Acne-removing essence cream based on plant extraction components and preparation method of acne-removing essence cream

Abstract

The invention provides acne-removing essence cream based on plant extraction components and a preparation method thereof. A macromolecular emulsifier 1 and a macromolecular emulsifier 2 are added into the acne-removing essence cream. The macromolecular emulsifier 1 is a product obtained by esterifying PEG100 stearate and acrylic acid and then carrying out free radical polymerization; the macromolecular emulsifier 2 is a product obtained by esterifying cetearyl glucoside and acrylic acid and then carrying out free radical polymerization on the esterified cetearyl glucoside and acrylic acid. Both the macromolecular emulsifier 1 and the macromolecular emulsifier 2 have macromolecular structures, so that the viscosity of the system can be improved, and meanwhile, a mutually wound network structure is easily formed among macromolecular chains, so that the cohesion of the system can be improved, and the viscosity of the system can be maintained. And on the other hand, a polymerization unit of the macromolecular emulsifier 2 contains a large number of hydroxyl groups, the density of hydrogen bonds after polymerization can be greatly improved, and the macromolecular emulsifier 2 can be more tightly combined with other components, so that the stability of the system is enhanced, and the viscosity of the system can be further stabilized.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to an acne-removing essence cream based on plant extracts and its preparation method. Background Technology

[0002] In the field of cosmetic technology, serum creams, as a common skincare product, typically contain an oil phase, a water phase, and various functional ingredients. Emulsifiers are the core components that ensure the uniform mixing of the oil and water phases and maintain the stability of the system. They not only promote the compatibility of ingredients with different polarities but also play a decisive role in the texture, spreadability, and skin feel of the product, directly affecting its overall quality and market acceptance. Therefore, they occupy an irreplaceable position in the research and development and production of serum creams.

[0003] In existing technologies, the emulsifiers used in serum creams are mostly small-molecule emulsifiers or conventional large-molecule emulsifiers, such as fatty acid esters and glycosides. These emulsifiers are usually added directly into the formulation system, and by utilizing the hydrophilic and hydrophobic groups in their molecular structure, they reduce the oil-water interfacial tension and help form a preliminary emulsion structure to meet the product's basic emulsification requirements.

[0004] However, the emulsifiers used in existing technologies still have significant limitations. Due to their molecular structure and performance characteristics, serum cream systems stabilized by these emulsifiers are prone to decreased stability and significant viscosity changes when subjected to environmental changes such as temperature fluctuations. This makes it difficult to maintain the uniformity and performance of the product over a long period, which has a significant impact on the storage, transportation, and actual use of serum creams, limiting their further application.

[0005] In conclusion, a new technical solution is urgently needed to address the problems existing in the current technology. Summary of the Invention

[0006] Based on this, the present invention provides an acne-removing essence cream based on plant extracts and its preparation method, wherein macromolecular emulsifier 1 and macromolecular emulsifier 2 are added; wherein macromolecular emulsifier 1 is the product of esterification of PEG100 stearate and acrylate followed by free radical polymerization; wherein macromolecular emulsifier 2 is the product of esterification of cetearyl glucoside and acrylate followed by free radical polymerization. Both macromolecular emulsifier 1 and macromolecular emulsifier 2 of the present invention have macromolecular structures, thus having an auxiliary effect on increasing the viscosity of the system. Simultaneously, the macromolecular chains easily form an intertwined network structure, which can significantly improve the cohesive force of the system and help maintain the viscosity of the system. On the other hand, the polymerization units of macromolecular emulsifier 2 of the present invention contain a large number of hydroxyl groups, and the density of hydrogen bonds after polymerization is greatly increased, enabling it to bind more tightly with other components, thereby enhancing the stability of the system and further stabilizing the viscosity of the system.

[0007] One object of the present invention is to provide an acne-removing essence cream based on plant extracts, the acne-removing essence cream based on plant extracts comprising the following components in parts by weight: Skin conditioning agent 1-10 parts 3-6 parts moisturizer 5-15 parts moisturizer Skin protectant 0.01-1 part 2-8 parts thickener 1-5 parts emulsifier Preservative 0.1-1 part Antioxidant 0.1-1 part Fragrance agent 0.01-0.1 parts Macromolecular emulsifier 1 0.1-2 parts Macromolecular emulsifier 2 0.1-2 parts Solvent 60-80 parts; The macromolecular emulsifier 1 is a product obtained by free radical polymerization after esterification of PEG100 stearate and acrylate. The macromolecular emulsifier 2 is a product obtained by free radical polymerization of cetearyl glucoside and acrylate after esterification.

[0008] Furthermore, the skin conditioning agent is selected from loquat leaf (ERIOBOTRYA JAPONICA) extract, phellodendron amurense bark extract, artemisia capillaris extract, mulberry (MORUS ALBA) root bark extract, licorice root extract, coptis chinensis root extract, sophora flavescens root extract, sumac gall extract, cnidium monnieri fruit extract, zanthoxylum bungeanum fruit extract, camphor tree (CINNAMOMUM CAMPHORA) leaf extract, and thyme. SERPYLLUM extract, nicotinamide, Bacillus fermentation product, mannitol, arginine, tetrahydromethylpyrimidine carboxylic acid, and Lactobacillus / soybean fermentation product filtrate.

[0009] Furthermore, the emollient is isohexadecane.

[0010] Furthermore, the moisturizer is selected from one or more of glycerin, ethylhexylglycerin, 1,3-propanediol, butylene glycol, hexanediol, 1,2-pentanediol, glycolic acid, and glyceryl caprylate.

[0011] Furthermore, the skin protectant is selected from one or more of the following: Pueraria lobata extract, Anemarrhena asphodeloides root extract, and Sophora japonica flower bud extract.

[0012] Furthermore, the thickener is selected from one or more of cetearyl alcohol and carbomer.

[0013] Furthermore, the emulsifier is selected from one or more of glyceryl stearate, capryloyl glycine, sunflower seed oil glycerides, and lauroyl wheat amino acid potassium.

[0014] Furthermore, the preservative is selected from one or more of phenoxyethanol and octanoyl hydroxamic acid.

[0015] Furthermore, the antioxidant is p-hydroxyacetophenone.

[0016] Furthermore, the fragrance agent is a flavoring.

[0017] Furthermore, the solvent is water.

[0018] Another object of the present invention is to provide a method for preparing the above-mentioned acne-removing essence cream based on plant extracts, comprising the following steps: S1. PEG100 stearate is blended with acrylic acid, an inhibitor and a catalyst are added, and the mixture is heated to react and obtain intermediate product 1; intermediate product 1 is blended with an initiator and heated to react and obtain macromolecular emulsifier 1. S2. Cetearyl glucoside is blended with acrylic acid, an inhibitor and a catalyst are added, and the mixture is heated to react, yielding intermediate product 2; intermediate product 2 is blended with an initiator and heated to react, yielding macromolecular emulsifier 2. S3. Prepare a premix by separately formulating a portion of the skin conditioning agent, a portion of the emulsifier, and a skin protectant; then heat and mix all components evenly to obtain an acne-removing essence cream based on plant extracts.

[0019] Further, in step S1, the mass ratio of PEG100 stearate to acrylic acid is 1:(0.05-0.5).

[0020] Furthermore, in step S1, the heating temperature in the reaction for preparing intermediate product 1 is 120-140℃; and the heating temperature in the reaction for preparing macromolecular emulsifier 1 is 60-80℃.

[0021] Further, in step S2, the mass ratio of cetearyl glucoside to acrylic acid is 1:(0.1-0.9).

[0022] Furthermore, in step S2, the heating temperature in the reaction for preparing intermediate product 2 is 120-140℃; and the heating temperature in the reaction for preparing macromolecular emulsifier 2 is 60-80℃.

[0023] The present invention has the following beneficial effects: This invention provides an acne-removing essence cream based on plant extracts and its preparation method, wherein macromolecular emulsifier 1 and macromolecular emulsifier 2 are added; macromolecular emulsifier 1 is the product of esterification of PEG100 stearate and acrylate followed by free radical polymerization; macromolecular emulsifier 2 is the product of esterification of cetearyl glucoside and acrylate followed by free radical polymerization. Both macromolecular emulsifier 1 and macromolecular emulsifier 2 of this invention have macromolecular structures, thus having an auxiliary effect on increasing the viscosity of the system. Simultaneously, the macromolecular chains easily form an intertwined network structure, which can significantly improve the cohesive force of the system and help maintain the viscosity. On the other hand, the polymerization units of macromolecular emulsifier 2 of this invention contain a large number of hydroxyl groups, and the density of hydrogen bonds is greatly increased after polymerization, enabling it to bind more tightly with other components, thereby enhancing the stability of the system and further stabilizing the viscosity. Detailed Implementation

[0024] To more clearly illustrate the technical solution of the present invention, the following embodiments are provided. Unless otherwise stated, the raw materials, reactions, and post-processing methods appearing in the embodiments are all commercially available raw materials and technical methods well known to those skilled in the art.

[0025] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0026] It should be understood that, except in any operational instance or otherwise indicated, the amounts or all figures representing ingredients used, for example, in the specification and claims, should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximate values ​​varying according to the desired performance to be obtained according to the invention.

[0027] The present invention uses the following raw materials: Loquat leaf extract, Phellodendron bark extract, Artemisia capillaris extract, Morus alba root bark extract, Glycyrrhiza glabra root extract, Coptis chinensis root extract, Sophora flavescens root extract, Rhus chinensis gall extract, Cnidium monnieri fruit extract, Zanthoxylum bungeanum fruit extract, Cinnamomum camphora leaf extract, Thyme diffusa extract, Pueraria lobata root extract, Anemarrhena asphodeloides root extract, Sophora japonica flower bud extract: purchased from Guangzhou Fuyulong Biotechnology Co., Ltd.

[0028] Bacillus fermentation products and Lactobacillus / soy milk fermentation product filtrate: purchased from Guangzhou Difensen Polypeptide Biotechnology Co., Ltd.

[0029] Carbomer: Grade CARBOPOL 940 Polymer, purchased from Lubrizol Advanced Materials.

[0030] Sunflower seed oil glycerides: purchased from Xianting (Guangzhou) Trading Co., Ltd.

[0031] Potassium lauroyl wheat amino acids: purchased from Xianting (Guangzhou) Trading Co., Ltd.

[0032] (Daily Use) Fragrance: Purchased from Givaudan Fragrance & Flavor (Guangzhou) Co., Ltd.

[0033] PEG100 stearate: purchased from Croda Chemicals (Shanghai) Co., Ltd.

[0034] All water used in this invention is deionized water.

[0035] In this invention, "parts" refers to parts by mass.

[0036] Examples 1-3 An acne-removing essence cream based on plant extracts, the composition of which is shown in Table 1: Table 1. Composition and dosage of Examples 1-3 If there are multiple raw materials listed above, it means that during the preparation process, multiple raw materials are first premixed to form a premix; the premix (parts) refers to the mass parts of each component in the premix. Of the above raw materials, those numbered 1, 4, 5, 6, 14, and 15 are phase A raw materials, those numbered 3, 7, 9, 10, and 13 are phase B raw materials, those numbered 16 are phase C raw materials, and those numbered 2, 8, 11, 12, 17, 18, 19, 20, and 21 are phase D raw materials.

[0037] The preparation method of the above-mentioned acne-removing essence cream based on plant extracts includes the following steps: S1. PEG100 stearate and acrylic acid are blended (the mass ratio of PEG100 stearate to acrylic acid is 1:0.2), and the polymerization inhibitor hydroquinone (acrylic acid 0.5 wt%) and the catalyst solid superacid SO4 are added. 2- ZrO2 (2 wt% of reactants) and xylene (80 wt% of reactants) were stirred and reacted at 135 °C for 12 h. The mixture was then azeotropically dehydrated using a water separator under normal pressure. The dehydrating agent was refluxed and recycled. After the reaction was completed, the mixture was cooled, filtered, and distilled under reduced pressure to obtain intermediate product 1. Using DMF as a solvent, intermediate product 1 was mixed with benzoyl peroxide (1 wt% of reactants) as an initiator and reacted at 80 °C for 8 h. After removing the solvent, macromolecular emulsifier 1 was obtained. S2. Cetearyl glucoside and acrylic acid are blended (the mass ratio of cetearyl glucoside to acrylic acid is 1:0.5), and the polymerization inhibitor hydroquinone (acrylic acid 0.5 wt%) and the catalyst solid superacid SO4 are added. 2- ZrO2 (2 wt% of reactants) and xylene (80 wt% of reactants) were stirred and reacted at 135 °C for 12 h. The mixture was then azeotropically dehydrated using a water separator under normal pressure. The dehydrating agent was refluxed and recycled. After the reaction was completed, the mixture was cooled, filtered, and distilled under reduced pressure to obtain intermediate product 2. Using DMF as a solvent, intermediate product 2 was mixed with benzoyl peroxide (1 wt% of reactants) as an initiator and reacted at 80 °C for 8 h. After removing the solvent, macromolecular emulsifier 2 was obtained. S3. According to the above mass proportions, first premix the components with multiple raw materials in the serial number to form a premix; then put the A phase raw material into the emulsification pot, heat to 80℃, and stir to disperse evenly; add the B phase raw material to the A phase raw material, stir homogenously evenly, keep warm for ten minutes to defoam, and cool to 60℃ for later use; add the C phase raw material and stir evenly, and cool to 40℃ for later use; add the D phase raw material and stir evenly to obtain the acne-removing essence cream based on plant extract ingredients.

[0038] Comparative Example 1 An acne-removing essence cream based on plant extracts. The difference between this comparative example and Example 1 is that step S1 is omitted. In step S3, the macromolecular emulsifier 1 is replaced with PEG100 stearate by an equal mass. Other steps and dosages are the same as in Example 1.

[0039] Comparative Example 2 An acne-removing essence cream based on plant extracts. The difference between this comparative example and Example 1 is that step S2 is omitted. In step S3, the macromolecular emulsifier 2 is replaced by cetearyl glucoside in equal mass. Other steps and dosages are the same as in Example 1.

[0040] Comparative Example 3 An acne-removing essence cream based on plant extracts. The difference between this comparative example and Example 1 is that step S2 is omitted. In step S3, the macromolecular emulsifier 2 is replaced with macromolecular emulsifier 1 by the same mass. Other steps and dosages are the same as in Example 1.

[0041] Test Example 1 The performance of the acne-removing essence creams based on plant extracts in Examples 1-3 and Comparative Examples 1-3 was tested.

[0042] Test method: Take an acne-removing essence cream based on plant extracts, store it at 40℃ for 24 hours, at room temperature for 24 hours, and then at -5℃ for 24 hours. Repeat this cycle 3 times and observe whether there is layering, floating oil, or color change. Test the viscosity before and after the test and compare whether the viscosity decreases.

[0043] The test results are shown in Table 2.

[0044] Table 2 Performance test results of the essence cream The test results above show that the acne-removing essence cream based on plant extracts of the present invention has good stability. After multiple changes in high and low temperature, there is no layering, no floating oil, and no change in color; and after multiple changes in high and low temperature, the viscosity remains at the original level.

[0045] Test Example 2 The acne-removing efficacy of the plant-based acne-removing essence cream of Example 1 was tested.

[0046] Test method: Thirty healthy Chinese male and female subjects aged 18-40 (16 males and 14 females) were recruited to evaluate the acne-reducing efficacy of the plant-based acne-reducing essence cream of this invention after 14 days. Reference standard: JYT-SOP-ZB-01 "Test method for skin acne spot erythema area ratio, number of red acne spots, and mean optical density of acne spots erythema".

[0047] Test process: (1) D0 (Initial value, before product use): Qualified subjects, after screening, cleaned their faces under the guidance of staff, and then wiped clean with lint-free absorbent paper towels. They sat quietly in a suitable room for at least 30 minutes, during which time they could not drink water or beverages, the test area was exposed, and they remained relaxed, avoiding touching the test area. After 30 minutes, researchers conducted instrument tests on the evaluation items.

[0048] (2) After the initial value is determined, test samples are distributed to the subjects and product instructions are provided to clarify the use of the product (including the application site, method of use, frequency of use, precautions, etc.) to ensure that the subjects can use the product correctly.

[0049] (3) After using the product continuously for 14 days as required, the subjects visited for testing. The testing requirements and procedures were consistent with the initial value determination. The researchers conducted instrument testing and data analysis on the evaluation items and recorded the adverse reactions.

[0050] The test results are shown in Table 3.

[0051] Table 3 Results of Acne Treatment Efficacy Test The test results above show that the plant-based acne-removing essence cream of this invention has good acne-removing efficacy. The average improvement rate of the number of acne spots in the red area is 29.05%, and the maximum improvement rate is 40.07%; the average improvement rate of the acne spot area ratio is 26.09%, and the maximum improvement rate is 36.23%; the average improvement rate of the acne spot optical density is 28.81%, and the maximum improvement rate is 39.83%. This invention has good acne-removing effects and no adverse reactions, and has good application prospects.

[0052] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

[0053] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. An acne-removing essence cream based on plant extracts, characterized in that, The plant-based acne-removing essence cream comprises the following components in parts by weight: Skin conditioning agent 1-10 parts 3-6 parts moisturizer 5-15 parts moisturizer Skin protectant 0.01-1 part 2-8 parts thickener 1-5 parts emulsifier Preservative 0.1-1 part Antioxidant 0.1-1 part Fragrance agent 0.01-0.1 parts Macromolecular emulsifier 1 0.1-2 parts Macromolecular emulsifier 2 0.1-2 parts Solvent 60-80 parts; The macromolecular emulsifier 1 is a product obtained by free radical polymerization after esterification of PEG100 stearate and acrylate. The macromolecular emulsifier 2 is a product obtained by free radical polymerization of cetearyl glucoside and acrylate after esterification.

2. The acne-removing essence cream based on plant extracts according to claim 1, characterized in that, The skin conditioning agent is selected from one or more of the following: loquat leaf extract, phellodendron bark extract, artemisia capillaris extract, mulberry root bark extract, licorice root extract, coptis root extract, sophora flavescens root extract, sumac gall extract, cnidium monnieri extract, zanthoxylum bungeanum fruit extract, camphor tree leaf extract, thyme extract, nicotinamide, Bacillus fermentation product, mannitol, arginine, tetrahydromethylpyrimidine carboxylic acid, and lactobacillus / soybean milk fermentation product filtrate.

3. The acne-removing essence cream based on plant extracts according to claim 1, characterized in that, The emollient is isohexadecane.

4. The acne-removing essence cream based on plant extracts according to claim 1, characterized in that, The moisturizer is selected from one or more of glycerin, ethylhexylglycerin, 1,3-propanediol, butylene glycol, hexanediol, 1,2-pentanediol, glycolic acid, and glyceryl caprylate.

5. The acne-removing essence cream based on plant extracts according to claim 1, characterized in that, The skin protectant is selected from one or more of the following: kudzu root extract, anemarrhena root extract, and sophora flower bud extract.

6. The method for preparing the acne-removing essence cream based on plant extracts according to any one of claims 1-5, characterized in that, Includes the following steps: S1. PEG100 stearate is blended with acrylic acid, an inhibitor and a catalyst are added, and the mixture is heated to react and obtain intermediate product 1; intermediate product 1 is blended with an initiator and heated to react and obtain macromolecular emulsifier 1. S2. Cetearyl glucoside is blended with acrylic acid, an inhibitor and a catalyst are added, and the mixture is heated to react, yielding intermediate product 2; intermediate product 2 is blended with an initiator and heated to react, yielding macromolecular emulsifier 2. S3. Prepare a premix by separately formulating a portion of the skin conditioning agent, a portion of the emulsifier, and a skin protectant; then heat and mix all components evenly to obtain an acne-removing essence cream based on plant extracts.

7. The method for preparing the acne-removing essence cream based on plant extracts according to claim 6, characterized in that, In step S1, the mass ratio of PEG100 stearate to acrylic acid is 1:(0.05-0.5).

8. The method for preparing the acne-removing essence cream based on plant extracts according to claim 6, characterized in that, In step S1, the heating temperature in the reaction for preparing intermediate product 1 is 120-140℃; in the reaction for preparing macromolecular emulsifier 1, the heating temperature is 60-80℃.

9. The method for preparing the acne-removing essence cream based on plant extracts according to claim 6, characterized in that, In step S2, the mass ratio of cetearyl glucoside to acrylic acid is 1:(0.1-0.9).

10. The method for preparing the acne-removing essence cream based on plant extracts according to claim 6, characterized in that, In step S2, the heating temperature in the reaction for preparing intermediate product 2 is 120-140℃; in the reaction for preparing macromolecular emulsifier 2, the heating temperature is 60-80℃.

Images