Oral whitening composition and application thereof

Abstract

The invention relates to an oral whitening composition and application thereof. The active ingredients of the composition comprise ergothioneine and a white tomato extract. The invention creatively provides an oral whitening scheme with high stability and high bioavailability, firstly proposes that the ergothioneine is used for repairing mitochondrial damage to block a melanin signal channel, the ergothioneine and a mechanism of intercepting ultraviolet rays in a corium layer of white tomatoes form a closed loop of'source prevention + medium-range blocking ', and the ergothioneine and the white tomatoes have a synergistic effect to generate 1 + 1gt; 2, through the synergistic interaction effect, the skin brightness is remarkably improved, the melanin index is reduced, and meanwhile, the multiple beneficial effects of moisturizing the skin, relieving and repairing, resisting oxidation, resisting aging and the like are achieved;

Description

Technical Field

[0001] This invention belongs to the field of functional food technology and relates to an oral whitening composition and its application. Background Technology

[0002] Skin pigmentation is a common skin problem plaguing modern populations. Physiologically, melanin production is a self-protective mechanism of the skin against ultraviolet (UV) radiation, but excessive accumulation can lead to age spots, dull skin tone, and uneven skin tone. With the development of the oral beauty market, oral whitening products based on ingredients such as Vitamin C, glutathione, and niacinamide have gained significant attention due to their "from the inside out" conditioning philosophy.

[0003] However, existing technologies still have significant drawbacks, such as poor stability and low bioavailability: traditional thiol antioxidants, represented by glutathione, have unstable chemical structures and are easily degraded by gastric acid and digestive enzymes during oral delivery, making it difficult to reach skin target cells at an effective concentration through systemic circulation, resulting in weak supplementation effects; their mechanisms of action are singular, neglecting upstream core inducing factors: existing strategies mostly focus on downstream processes, namely blocking melanin production by inhibiting tyrosinase activity. However, UV-induced pigmentation first induces mitochondrial dysfunction, triggering "mitochondrial stress" and reactive oxygen species bursts, which in turn activate upstream signaling pathways. Traditional ingredients do not block this source, thus only treating the symptoms, not the root cause; and their synergistic effects are insufficient, lacking in vivo protective mechanisms: commercially available products often simply stack multiple antioxidants, ignoring the interactions of active ingredients in the human body's internal environment. This combination lacks a mechanism for mutual regeneration and recycling, causing the ingredients to be rapidly metabolized before reaching the target site, making it difficult to achieve synergistic effects.

[0004] Therefore, developing a highly effective oral skin whitening product that can overcome the aforementioned stability challenges and has mitochondrial targeting has become an urgent technical problem to be solved in this field. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide an oral whitening composition and its application.

[0006] To achieve this objective, the present invention adopts the following technical solution: In a first aspect, the present invention provides an oral whitening composition, wherein the active ingredients of the composition include ergothioneine and white tomato extract.

[0007] This invention creatively provides an oral whitening solution with high stability and high bioavailability. It is the first to propose using ergothioneine to repair "mitochondrial damage" to block the melanin signaling pathway. This, combined with the mechanism of white tomato blocking ultraviolet rays in the dermis, forms a closed loop of "source prevention + mid-range blocking". The two work synergistically to produce a synergistic effect of 1+1>2, significantly improving skin brightness and reducing melanin index. At the same time, it has many beneficial effects such as skin moisturizing, soothing and repairing, anti-oxidation, and anti-aging.

[0008] Preferably, the mass ratio of ergothioneine to white tomato extract is (0.1-20):1 (e.g., it can be 0.1:1, 0.5:1, 1:1, 2:1, 5:1, 7:1, 10:1, 12:1, 15:1, 17:1, 20:1, etc.).

[0009] All other specific point values ​​not listed above within the numerical ranges mentioned above can be selected and are all within the protection scope of this invention. For the sake of brevity, they will not be described in detail here.

[0010] Preferably, the composition further includes excipients acceptable in the functional food industry.

[0011] Preferably, the excipients acceptable in the functional food field include any one or a combination of at least two of the following: carrier, diluent, excipient, filler, binder, wetting agent, disintegrant, emulsifier, solubilizer, osmotic pressure regulator, surfactant, coating material, colorant, pH adjuster, antioxidant, antibacterial agent, or buffer.

[0012] In a second aspect, the present invention provides the use of the oral whitening composition as described in the first aspect in the preparation of skin antioxidant products.

[0013] Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

[0014] Thirdly, the present invention provides the use of the oral whitening composition as described in the first aspect in the preparation of skin whitening products.

[0015] Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

[0016] Fourthly, the present invention provides the use of the oral whitening composition as described in the first aspect in the preparation of moisturizing products.

[0017] Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

[0018] Fifthly, the present invention provides the use of the oral whitening composition as described in the first aspect in the preparation of skin soothing and repair products.

[0019] Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

[0020] In a sixth aspect, the present invention provides the use of the oral whitening composition as described in the first aspect in the preparation of anti-aging products.

[0021] Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

[0022] Compared with the prior art, the present invention has the following beneficial effects: This invention creatively provides an oral whitening solution with high stability and high bioavailability. It is the first to propose using ergothioneine to repair "mitochondrial damage" to block the melanin signaling pathway. This, combined with the mechanism of white tomato blocking ultraviolet rays in the dermis, forms a closed loop of "source prevention + mid-range blocking". The two work synergistically to produce a synergistic effect of 1+1>2, significantly improving skin brightness and reducing melanin index. At the same time, it has many beneficial effects such as skin moisturizing, soothing and repairing, anti-oxidation, and anti-aging. Detailed Implementation

[0023] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0024] The ergothioneine used in the embodiments and comparative examples of this application was provided by Jiangsu Jinsan Biotechnology Co., Ltd., with a content greater than 99.5%; the white tomato extract was provided by Shanyi Foods (Shanghai) Co., Ltd., product code R0019.

[0025] Example 1 This embodiment provides an oral skin whitening composition, the preparation method of which is as follows: Ergothioneine and white tomato extract were mixed at a mass ratio of 2:1 at 25°C to obtain the oral whitening composition.

[0026] Example 2 This embodiment provides an oral skin whitening composition, the preparation method of which is as follows: Ergothioneine and white tomato extract were mixed at a mass ratio of 1:1 at 25°C to obtain the oral whitening composition.

[0027] Example 3 This embodiment provides an oral skin whitening composition, the preparation method of which is as follows: Ergothioneine and white tomato extract were mixed at a mass ratio of 1:2 at 25°C to obtain the oral whitening composition.

[0028] Example 4 This embodiment provides an oral whitening composition. The preparation method differs from that of Example 1 only in that the mass ratio of ergothioneine and white tomato extract is changed to 1:15, while other conditions remain unchanged.

[0029] Example 5 This embodiment provides an oral whitening composition. The preparation method differs from that of Example 1 only in that the mass ratio of ergothioneine and white tomato extract is changed to 22:1, while other conditions remain unchanged.

[0030] Comparative Example 1 This comparative example provides an oral whitening composition. The preparation method differs from Example 1 only in that ergothioneine is not added, and the reduced mass of ergothioneine is allocated entirely to the white tomato extract, while other conditions remain unchanged.

[0031] Comparative Example 2 This comparative example provides an oral whitening composition. The preparation method differs from Example 1 only in that white tomato extract is not added, and the reduced mass of white tomato extract is entirely allocated to ergothioneine, while other conditions remain unchanged.

[0032] Test Example 1 This test case examines the human efficacy of the oral whitening compositions prepared in Examples 1-5 and Comparative Examples 1-2.

[0033] Experimental types: single-center, open-label, pre- and post-control, single-group experiment Subject size: 210 subjects were selected and randomly divided into 7 groups of 30 each.

[0034] Subject requirements: Healthy individuals aged 25-50 years with dull, lackluster skin and facial pigmentation.

[0035] Observation period: A 56-day oral trial was conducted on each group of subjects. During the 56 days, each subject took 180 mg of the corresponding group's oral whitening composition daily. Subjects were tested before using the product (D0) and after 56 days of continuous use (D56), and the improvement rate was calculated.

[0036] Testing Procedure: Subjects cleansed the test area using standardized facial cleansing products provided by staff, and gently dried with disposable cotton towels. Personal skincare products were prohibited. Subjects then sat and rested in a temperature and humidity controlled room, refraining from touching the test area, speaking, or eating, before the test was conducted. The ambient temperature was 21±1℃, and the humidity was 50±10% RH.

[0037] The test metrics are as follows: 1. Skin radiance Test equipment: Facial images were captured using Visia and automatically analyzed using Image ProPlus 7.0 software.

[0038] Evaluation criteria: "Skin radiance parameter" is extracted using software. The higher the value, the more radiant the skin. 2. Skin whiteness (ITA value) Test equipment: Visia combined with Image ProPlus 7.0 for automatic analysis.

[0039] Evaluation criteria: A significant increase in the ITA value indicates that the skin color is whiter, proving that the product has the effect of improving skin whiteness.

[0040] 3. Melanin content (MI value) Test equipment: Mexameter MX 18.

[0041] Evaluation criteria: A significant decrease in the MI value indicates that the sample has the effect of reducing skin melanin.

[0042] The test results are shown in Table 1. The results showed that the oral whitening composition prepared by the present invention has excellent effects in improving skin radiance, increasing ITA value, and reducing melanin MI value; if the mass ratio of ergothioneine and white tomato extract is changed, or if either ergothioneine or white tomato extract is missing, the effect of the composition will decrease.

[0043] The applicant declares that the technical solution of this invention is illustrated by the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of raw materials for the products of this invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of this invention.

[0044] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0045] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. An oral whitening composition, characterized in that, The active ingredients of the composition include ergothioneine and white tomato extract.

2. The oral whitening composition according to claim 1, characterized in that, The mass ratio of ergothioneine to white tomato extract is (0.1-20):

1.

3. The oral whitening composition according to claim 1 or 2, characterized in that, The composition also includes excipients acceptable in the functional food industry.

4. The oral whitening composition according to claim 3, characterized in that, The excipients acceptable in the functional food field include any one or a combination of at least two of the following: carriers, diluents, excipients, fillers, binders, wetting agents, disintegrants, emulsifiers, solubilizers, osmotic pressure regulators, surfactants, coating materials, colorants, pH adjusters, antioxidants, antibacterial agents, or buffers.

5. The use of the oral whitening composition according to any one of claims 1-4 in the preparation of skin antioxidant products; Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

6. The use of the oral whitening composition according to any one of claims 1-4 in the preparation of skin whitening products; Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

7. The use of the oral whitening composition according to any one of claims 1-4 in the preparation of skin moisturizing products; Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

8. The use of the oral whitening composition according to any one of claims 1-4 in the preparation of skin soothing and repair products; Preferably, the dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

9. The use of the oral whitening composition according to any one of claims 1-4 in the preparation of skin anti-aging products.

10. The application according to claim 9, characterized in that, The dosage form of the product includes any one of tablets, capsules, granules, powders, oral liquids, syrups, suspensions, dry suspensions, or pills.

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